Index

A C A21978C, 110 Capreomycin, 278 A54145, 110 Carbapenem, 60 Acinetobacter baumannii, 29, 31, 38 Carbapenemases, 31, 41, 46 Actinobacteria, 7 Cationic detergents, 167 Actinonin, 279, 288 CB-182,804, 160–162, 169, 170 Agar-diffusion technologies, 344 CB-813,315, 109 Agar-diffusion two-plate differential sensitiv- CDA, 110 ity assay, 344 Ceftaroline, 15, 17 AISS profile, 351 Cephalosporins, 36, 37, 39, 40, 45, 60 Amikacin, 201 Cethromycin, 214 4-aminoarabinose, 166 Cetyltriammonium, 167 2-aminodecanoyl, 167 Cetyltriammonium chloride, 167 Aminoglycosides, 33, 34, 36, 37, 168, 194 Chemical libraries, 329 Amphomycin, 110 Chloramphenicol, 271 Antisense target-based whole cell screens, 343 Chlortetracycline, 232 Anti-virulence drugs, 354 Chromobacterium violaceum, 166 Apramycin, 198 Clarithromycin, 162, 163, 167, 211 Azithromycin, 211 Clavulanate, 60 Aztreonam, 67 Clindamycin, 268 Clostridium difficile, 12, 19, 85, 86, 90, 101, 109, 268 B Colistin methanesulfonate (CMS), 161, 167, Bacillus subtilis, 109 168, 170 Bacterial cell wall, 85, 93 Colistins, 31, 33, 35, 36, 39, 42, 43, 47, 48, Bactericidal, 307, 308, 314, 318 159–161, 164, 165, 167 Bacteriostatic, 231 Combinatorial biosynthesis, 124 BAL19403, 216 Community-acquired bacteremias, 160 BB83698, 296 Community-acquired infections, 12 Benzalkonium chloride, 167 Complement system, 163 Bicyclolides, 215 Cystic fibrosis, 161 Bile acids, 166 Bioassay-guided purification, 336 Biosynthetic pathway D Blasticidin S, 279, 280 Dalbavancin, 85, 89, 91, 92, 164 Burkholderia cepacia, 166 Dalfopristin, 270 Butirosin, 196 Daptomycin, 11, 15, 17–19, 109

F. Marinelli and O. Genilloud (eds.), Antimicrobials, 361 DOI: 10.1007/978-3-642-39968-8, Ó Springer-Verlag Berlin Heidelberg 2014 362 Index

Deinococcus radiodurans, 269 Healthcare-associated bacteremias, 160 Dibekacin, 201 Hemoperfusion, 161 Dirithromycin, 213 High throughput mass spectrometry assay, 342 DNA filamentation, 330 High throughput screening (HTS), 329 Doxycycline and minocycline, 234 Histamine, 170 Duramycin A, 153 Hits, 334 Hormesis, 8 Hydroxamic acids, 287 E Hygromycin B, 198 Efflux, 300 Efflux transporters, 231 Encoded library technology (ELT), 353 I Enterobacteriaceae, 29, 31, 34, 40–42, 44–47 Imipenem, 65 Enterococci, 11, 12, 18, 85, 87, 90, 91, 96–98 Isepamicin, 201 Enterococcus faecalis, 18, 19, 109 Isoprenoid biosynthesis, 342 Enterococcus faecium, 18, 109 Erythromycin, 163, 211 Erythromycylamine, 213 J Etimicin, 201 Josamycin, 217 Everninomicin, 279 Extended-spectrum ß-lactamases (ESBLs), 31, 34, 40, 41, 45–48 K Kanamycin A, 196 Kanamycin B, 196 F Ketolides, 166, 211 Fatty acid biosynthetic pathway, 343 Klebsiella pneumoniae, 29, 31, 40, 42 Fidaxomicin, 20 Flopristin, 271 Fluoroquinolones, 33, 34, 41, 46, 47 L Flurithromycin, 213 b-lactam, 9 Fortimicin A, 198 b-lactam antibiotics, 31, 34, 43 Fragment-based lead discovery (FBLD), 353 b-lactamase, 60 Fragment-based drug discovery, 329 LBM415, 296 Friulimicin, 110 Leads, 329 Function-oriented synthetic approach, 186 Leucomycin, 217 Fusidic acid, 274 LiaRS, 117 Lincomycin, 268 Lincosamine, 268 G Lincosaminides, 268 Gamithromycin, 216 Linezolid, 11, 15, 16, 18, 19, 247–249, 251, GE2270A, 276 253, 254, 257, 260 Genome-wide Fitness Test, 350 Linopristin, 271 Gentamicin, 169, 196 Lipid A, 166, 341 Glycopeptide resistance, 85, 102 Lipoglycopeptides, 87, 95 Glycopeptides, 85, 87, 88, 90–92, 95–102 Lipopeptides, 166 Glycylcyclines, 236 Lipopolysaccharide (LPS), 160, 166, 341 GRE, 11, 12, 16, 18, 19 Lividomycin, 195 GSK1322322, 279, 296 LpxC enzymes, 166 GSK2251052, 279

M H Macrolides, 163, 211 Habekacin, 201 MDR, 30, 31, 33, 36, 37, 39, 42, 44, 45, 47, 48 Haloarculamarismortu, 269 Megalin, 168, 169 Index 363

Methicillin-resistant Staphylococcus aureus Penicillin, 60 (MRSA), 11, 12, 14, 63 Penicillin-binding protein, 61 Microbisporicin, 151 Peptide deformylase, 288 Micrococcin, 276 Peptide deformylase inhibitors, 166 Midecamycin, 217 Peptidoglycan, 71, 337 Miokamycin, 217 Peritoneal infection, 163 Mirincamycin, 269 Peritonitis model, 163 MLSB resistance, 221 Phenotypic assays, 329 Modithromycin, 214 Phosphonic acid derivatives, 35 Mono-acetyl polymyxin B, 164 Phosphoryl ethanolamine, 166 Monobactams, 36, 45, 60 Pikromycin, 221 Monocarbam, 68 Pirlimycin, 269 Monosulfactam, 68 Plazomicin, 202 mprF, 115 Pleuromutilins, 166, 272 MraY inhibition, 186 pmrA mutants, 166 Mucin, 163 Polyketide synthase, 224 Mupirocin, 275 Polymyxin B, 159–161, 164, 167–171 Mur pathway, 338 Polymyxin B nonapeptide (PMBN), 160, 162, Muraymycin A1, 184 163, 168–170 Muropeptide, 71 Polymyxins, 165–167, 170 Mutacin 1140, 151 Polysorbate 80, 164 Mutasynthesis, 182 Pristinamycins, 270 Protein synthesis, 288 Proteus mirabilis, 166 N Pseudomonas aeruginosa, 29, 31, 33–36, 38, NAB7061, 159, 160, 163, 167, 169, 171 45–48 NAB739, 159, 160, 162, 167, 169, 171 Pseudomonic acid, 275 NAB741, 159, 160, 163, 169–171 Neomycin, 195 Nephrotoxicity, 168 Q Netilmicin, 201 Quinolone, 307, 308, 311, 312, 314–319, 322 Neuromuscular blockade, 170 Quinopristin, 271 Neurotoxicity, 170 Quinupristin-dalfopristin, 18 Norepinephrine, 5 Nucleoside antibiotics, 177 NVB302, 152 R Radezolid, 255, 256 Reactive oxygen, 76 O Renal proximal tubuli, 168 Octapeptin EM49, 167 Retapamulin, 273 Oritavancin, 85, 89–92, 164 Ribostamycin, 195 Orthosomycin, 278 Rifampin, 162, 163, 167 Oxazolidin-2-ones, 247, 248, 252–254, Rifamycins, 163 258–260 Rifaximin, 20 Oxazolidinones, 166 RNA world, 8 Oxytetracycline, 232 Rokitamycin, 217 Roxithromycin, 213 rpoB, 115 P RX-04, 280 Pacidamycin biosynthetic pathway, 180 Panton–Valentine leukocidin, 14 Paromomycin, 195 S Parvome, 3 Saccharopolyspora erythraea, 212 PDR, 30, 31, 33, 36–38, 40, 42 Salmonella typhimurium, 166 364 Index

Siderophore, 68 Tiamulin, 273 Sisomicin, 196 Tigecycline, 15, 18, 19, 34, 39, 43, 44, 239 Solithromycin, 216 Tildipirosin, 216 Spectinomycin, 198 Tilmicosin, 216 Spiramycin, 216 Tobramycin, 196 Spontaneous resistance, 300 Translocase I inhibition, 183 Staphylococci, 87, 90, 91 Tulathromycin, 216 Staphylococcus aureus, 11, 85–87, 90, 94, 96, Tylosin, 216 109 Streptogramin A, 270 Streptogramin B, 270 V Streptomyces fradiae, 111 Valnemulin, 273 Streptomyces roseosporus, 110 Vancomycin, 15, 20, 61, 85–92, 94–102, 163 Streptomycin, 194 Vancomycin-resistant enterococci (VRE), 87, Structure-based drug design, 329 90, 92, 93, 96–98 Structure-based drug discovery, 352 Vancomycin-resistant Staphylococcus aureus Sutezolid, 256, 257 (VRSA), 16, 92, 96, 97 Synercid, 270 Verdamicin, 202 Vertilmicin, 202 Virginiamycins, 270 T VISA, 15, 116 Target-based whole cell assays, 329 Tedizolid, 257, 258, 260 Teichoic acid, 76, 341 X Teicoplanin, 15, 17, 85–92, 95, 97–101 XDR, 30, 31, 33, 37, 39, 40, 42, 44 Telavancin, 15, 17, 85, 89–91, 98 X-ray crystal structure based design, 344, 350 Telithromycin, 211 X-ray crystallography, 289 Tetracyclines, 231 Xylostasin, 196 Thiopeptide, 276 Thiostrepton, 276