A Historical Perspective on Empirical and Rational Design
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Fundamentals of Machine Design
Module 1 Fundamentals of machine design Version 2 ME, IIT Kharagpur Lesson 1 Design philosophy Version 2 ME, IIT Kharagpur Instructional Objectives At the end of this lesson, the students should have the knowledge of • Basic concept of design in general. • Concept of machine design and their types. • Factors to be considered in machine design. 1.1.1 Introduction Design is essentially a decision-making process. If we have a problem, we need to design a solution. In other words, to design is to formulate a plan to satisfy a particular need and to create something with a physical reality. Consider for an example, design of a chair. A number of factors need be considered first: (a) The purpose for which the chair is to be designed such as whether it is to be used as an easy chair, an office chair or to accompany a dining table. (b) Whether the chair is to be designed for a grown up person or a child. (c) Material for the chair, its strength and cost need to be determined. (d) Finally, the aesthetics of the designed chair. Almost everyone is involved in design, in one way or the other, in our daily lives because problems are posed and they need to be solved. 1.1.2 Basic concept of machine design Decision making comes in every stage of design. Consider two cars of different makes. They may both be reasonable cars and serve the same purpose but the designs are different. The designers consider different factors and come to certain conclusions leading to an optimum design. -
Heinrich Parler
Heinrich Parler Heinrich Parler the Elder (also Heinrich of Gmünd; German: Heinrich von Gemünd der Ältere; born between 1300 and 1310 â“ circa 1370), was a German architect and master builder of the Gothic period. Heinrich Parler was probably born in Cologne between 1300 and 1310, but later lived and worked in Gmünd, an Imperial City (German: Reichsstädte) of the Holy Roman Empire.[2] He became construction manager of Holy Cross Minster in Gmünd between 1325 and 1330. Heinrich Harrer (German pronunciation: [ˈhaɪnÊɪç ˈhaÊÉ]; 6 July 1912 â“ 7 January 2006) was an Austrian mountaineer, sportsman, geographer, and author. He is best known for being on the four-man climbing team that made the first ascent of the North Face of the Eiger in Switzerland, and for his books Seven Years in Tibet (1952) and The White Spider (1959). Heinrich Harrer was born 6 July 1912 in Hüttenberg, Austria, in the district of Sankt Veit an der Glan in the state of Carinthia. His father was a Heinrich Parler the Elder (also Heinrich of Gmünd, German: Heinrich von Gemünd der Ältere; c. 1310 â“ c. 1370), was a German architect and sculptor. His masterpiece is Holy Cross Minster, an influential milestone of late Gothic architecture in the town of Schwäbisch Gmünd, Baden- Württemberg, Germany. Parler also founded the Parler family of master builders and his descendants worked in various parts of central Europe, especially Bohemia. His son, Peter Parler, became one of the major architects of the Heinrich Harrer was an Austrian mountaineer who was part of the team that made the first ascent of the formidable north wall of the Eiger in Switzerland. -
Rational Design of Pore Size and Functionality in a Series of Isoreticular Zwitterionic Metal-Organic Frameworks
1 Rational Design of Pore Size and Functionality in a Series of Isoreticular Zwitterionic Metal-Organic Frameworks Darpandeep Aulakh,†,|| Timur Islamoglu,‡,|| Veronica F. Bagundes,† Juby R. Varghese,† Kyle Duell,† Monu Joy,† Simon J. Teat,§ Omar K. Farha‡,ǂ and Mario Wriedt*,† †Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, New York 13699, United States of America ‡Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States of America §Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States of America ǂDepartment of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia ||D.A. and T.I. contributed equally to this work. * Tel.: +1(315) 268-2355 Fax: +1(315) 268-6610 Email: [email protected] 2 Abstract The isoreticular expansion and functionalization of charged-polarized porosity has been systematically explored by the rational design of eleven isostructural zwitterionic metal-organic frameworks (ZW-MOFs). This extended series of general structural composition {[M3F(L1)3(L2)1.5]·guests}n was prepared by employing the solvothermal reaction of Co and Ni tetrafluoroborates with a binary ligand system composed of zwitterionic pyridinium derivatives and traditional functionalized ditopic carboxylate auxiliary ligands (HL1·Cl = 1-(4- carboxyphenyl)-4,4′-bipyridinium chloride, Hcpb·Cl; or 1-(4-carboxyphenyl-3-hydroxyphenyl)- 4,4′-bipyridinium chloride, Hchpb·Cl; and H2L2 = benzene-1,4-dicarboxylic acid, H2bdc; 2- aminobenzene-1,4-dicarboxylic acid, H2abdc; 2,5-dihydroxy-1,4-benzenedicarboxylic acid, H2dhbdc; biphenyl-4,4’-dicarboxylic acid, H2bpdc; or stilbene-4,4’-dicarboxylic acid, H2sdc). Single-crystal structure analyses revealed cubic crystal symmetry (I-43m, a = 31-36 Å) with a 3D pore system of significant void space (73-81%). -
Introduction to Machine Design and Its Classifications
Introduction to Machine Design and its classifications Introduction to Machine Design Machine Design is the innovation of new and effective machines and improving the existing ones. A new or effective machine is one which is more economical in the overall cost of production and operation. The design is to formulate a plan for the satisfaction of a human need. In designing a machine component, it is necessary to have a good knowledge of many subjects such as Mathematics, Engineering Mechanics, Strength of Materials, Theory of Machines, Workshop Processes and Engineering Drawing. Classifications of Machine Design The machine design may be classified as follows: 1. Adaptive design: In this the designer’s work is concerned with adaptation of existing designs. The designer only makes minor alternation or modification in the existing designs of the product. 2. Development design: This type of design needs scientific training and design ability in order to modify the existing designs into a new idea by adopting a new material or different method of manufacture. 3. New design: This type of design needs lot of research, technical ability and creative thinking. Only those designers who have personal qualities of a sufficiently high order can take up the work of a new design. 4. Rational design: This type of design depends upon mathematical formulae of principle of mechanics. 5. Empirical design: This type of design depends upon empirical formulae based on the practice and past experience. 6. Industrial design: This type of design depends upon the production aspects to manufacture any machine component in the industry. 7.Optimum design: It is the best design for the given objective function under the specified constraints. -
Geometric Proportioning Strategies in Gothic Architectural Design Robert Bork*
$UFKLWHFWXUDO Bork, R 2014 Dynamic Unfolding and the Conventions of Procedure: Geometric +LVWRULHV Proportioning Strategies in Gothic Architectural Design. Architectural Histories, 2(1): 14, pp. 1-20, DOI: http://dx.doi.org/10.5334/ah.bq RESEARCH ARTICLE Dynamic Unfolding and the Conventions of Procedure: Geometric Proportioning Strategies in Gothic Architectural Design Robert Bork* This essay explores the proportioning strategies used by Gothic architects. It argues that Gothic design practice involved conventions of procedure, governing the dynamic unfolding of successive geometrical steps. Because this procedure proves difficult to capture in words, and because it produces forms with a qualitatively different kind of architectural order than the more familiar conventions of classical design, which govern the proportions of the final building rather than the logic of the steps used in creating it, Gothic design practice has been widely misunderstood since the Renaissance. Although some authors in the nineteenth and twentieth centuries attempted to sympathetically explain Gothic geometry, much of this work has been dismissed as unreliable, especially in the influential work of Konrad Hecht. This essay seeks to put the study of Gothic proportion onto a new and firmer foundation, by using computer-aided design software to analyze the geometry of carefully measured buildings and original design drawings. Examples under consideration include the parish church towers of Ulm and Freiburg, and the cross sections of the cathedrals of Reims, Prague, and Clermont-Ferrand, and of the Cistercian church at Altenberg. Introduction of historic monuments to be studied with new rigor. It is Discussion of proportion has a curiously vexed status in finally becoming possible, therefore, to speak with reason- the literature on Gothic architecture. -
Recent Advances in Automated Protein Design and Its Future
EXPERT OPINION ON DRUG DISCOVERY 2018, VOL. 13, NO. 7, 587–604 https://doi.org/10.1080/17460441.2018.1465922 REVIEW Recent advances in automated protein design and its future challenges Dani Setiawana, Jeffrey Brenderb and Yang Zhanga,c aDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; bRadiation Biology Branch, Center for Cancer Research, National Cancer Institute – NIH, Bethesda, MD, USA; cDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA ABSTRACT ARTICLE HISTORY Introduction: Protein function is determined by protein structure which is in turn determined by the Received 25 October 2017 corresponding protein sequence. If the rules that cause a protein to adopt a particular structure are Accepted 13 April 2018 understood, it should be possible to refine or even redefine the function of a protein by working KEYWORDS backwards from the desired structure to the sequence. Automated protein design attempts to calculate Protein design; automated the effects of mutations computationally with the goal of more radical or complex transformations than protein design; ab initio are accessible by experimental techniques. design; scoring function; Areas covered: The authors give a brief overview of the recent methodological advances in computer- protein folding; aided protein design, showing how methodological choices affect final design and how automated conformational search protein design can be used to address problems considered beyond traditional protein engineering, including the creation of novel protein scaffolds for drug development. Also, the authors address specifically the future challenges in the development of automated protein design. Expert opinion: Automated protein design holds potential as a protein engineering technique, parti- cularly in cases where screening by combinatorial mutagenesis is problematic. -
A Rational Design Process: How and Why to Fake It
A RATIONAL DESIGN PROCESS: HOW AND WHY TO FAKE IT David L. Parnas Computer Science Department University of Victoria Victoria BC V8W 2Y2 Canada and Computer Science and Systems Branch Naval Research Laboratory Washington DC 20375 USA and Paul C. Clements Computer Science and Systems Branch Naval Research Laboratory Washington DC 20375 USA I. THE SEARCH FOR THE PHILOSOPHER'S STONE: WHY DO WE WANT A RATIONAL DESIGN PROCESS? A perfectly rational person is one who always has a good reason for what he does. Each step taken can be shown to be the best way to get to a well defined goal. Most of us like to think of ourselves as rational professionals. However, to many observers, the usual process of designing software appears quite irra- tional. Programmers start without a clear statement of desired behavior and implementation constraints. They make a long sequence of design decisions with no clear statement of why they do things the way they do. Their rationale is rarely explained. Many of us are not satisfied with such a design process. That is why there is research in software design, programming methods, structured programming and related topics. Ideally, we would like to derive our programs from a statement of requirements in the same sense that theorems are derived from axioms in a published proof. All of the methodologies that can be con- sidered "top down" are the result of our desire to have a rational, systematic way of designing software. This paper brings a message with both bad news and good news. The bad news is that, in our opinion, we will never find the philosopher's stone. -
Rational Design" of Investment Treaties
Not the Least BIT Rational: An Empirical Test of the "Rational Design" of Investment Treaties Todd Allee Assistant Professor Department of Political Science University of Illinois 361 Lincoln Hall, 702 South Wright Street Urbana, Illinois 61801 [email protected] Clint Peinhardt Assistant Professor School of Economic, Political and Policy Sciences The University of Texas at Dallas 800 West Campbell Rd. GR31 Richardson, TX 75080 [email protected] Paper prepared for submission to the 1st Conference on the Political Economy of International Organizations Monte Verità, Switzerland 3-8 February 2008 Introduction In the 1990s a wave of bilateral investment treaties (BITs) were signed by numerous pairs of governments. In fact, nearly 200 of these treaties, which specify the rules governing foreign direct investment (FDI) between the signatories, were signed in 1994 alone. The United Kingdom (UK) was among the most active BIT signers that year and on March 1 st , 1994 it signed a BIT with Belarus. That BIT contained language stating that if a dispute between a multinational corporation from one state and the government of the other were to erupt, the multinational would be entitled to pursue remedies through the International Centre for the Settlement of Investment Disputes (ICSID), a neutral, prominent, and regularized judicial institution associated with the World Bank. In effect, what the UK-Belarus BIT said was that British firms would be able to directly challenge actions taken by the Belarusian government via the most public and well-known arbitration institution available, without any ability of the Belarusian government to prevent this course of action. -
Design Philosophy
Instructional Objectives At the end of this lesson, the students should have the knowledge of • Basic concept of design in general. • Concept of machine design and their types. • Factors to be considered in machine design. 1.1.1 Introduction Design is essentially a decision-making process. If we have a problem, we need to design a solution. In other words, to design is to formulate a plan to satisfy a particular need and to create something with a physical reality. Consider for an example, design of a chair. A number of factors need be considered first: (a) The purpose for which the chair is to be designed such as whether it is to be used as an easy chair, an office chair or to accompany a dining table. (b) Whether the chair is to be designed for a grown up person or a child. (c) Material for the chair, its strength and cost need to be determined. (d) Finally, the aesthetics of the designed chair. Almost everyone is involved in design, in one way or the other, in our daily lives because problems are posed and they need to be solved. 1.1.2 Basic concept of machine design Decision making comes in every stage of design. Consider two cars of different makes. They may both be reasonable cars and serve the same purpose but the designs are different. The designers consider different factors and come to certain conclusions leading to an optimum design. Market survey gives an indication of what people want. Existing norms play an important role. Once a critical decision is made, the rest of the design features follow. -
Computational Protein Engineering: Bridging the Gap Between Rational Design and Laboratory Evolution
Int. J. Mol. Sci. 2012, 13, 12428-12460; doi:10.3390/ijms131012428 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 www.mdpi.com/journal/ijms Review Computational Protein Engineering: Bridging the Gap between Rational Design and Laboratory Evolution Alexandre Barrozo 1, Rok Borstnar 1,2, Gaël Marloie 1 and Shina Caroline Lynn Kamerlin 1,* 1 Department of Cell and Molecular Biology, Uppsala Biomedical Center (BMC), Uppsala University, Box 596, S-751 24 Uppsala, Sweden; E-Mails: [email protected] (A.B.); [email protected] (R.B.); [email protected] (G.M.) 2 Laboratory for BiocomputinG and Bioinformatics, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +46-18-471-4423; Fax: +46-18-530-396. Received: 20 August 2012; in revised form: 16 September 2012 / Accepted: 17 September 2012 / Published: 28 September 2012 Abstract: Enzymes are tremendously proficient catalysts, which can be used as extracellular catalysts for a whole host of processes, from chemical synthesis to the generation of novel biofuels. For them to be more amenable to the needs of biotechnoloGy, however, it is often necessary to be able to manipulate their physico-chemical properties in an efficient and streamlined manner, and, ideally, to be able to train them to catalyze completely new reactions. Recent years have seen an explosion of interest in different approaches to achieve this, both in the laboratory, and in silico. There remains, however, a gap between current approaches to computational enzyme desiGn, which have primarily focused on the early stages of the design process, and laboratory evolution, which is an extremely powerful tool for enzyme redesign, but will always be limited by the vastness of sequence space combined with the low frequency for desirable mutations. -
Solving Puzzle Design
Solving Puzzle Design Jolie Menzel Level Designer, Ubisoft SF Why Puzzles? PUZZLES LEVEL DIFFICULTY MECHANICS NARRATIVE PROGRESSION DESIGN BALANCING Overview ● What is a puzzle? ● What makes a puzzle “good”? ● Elements of a puzzle ● Rational puzzle design ● Building a puzzle ● Troubleshooting your puzzle What is a Puzzle? What Is a Puzzle? “A“A puzzle is a game with aone dominant solution” strategy.” “AGames dominant are played strategy to iswin when choices are offered Puzzlesto a player are played, but one to findof them a is clearly better solutionthan the rest.” - Jesse Schell What Is a Puzzle? A challenge – but not a competitive challenge. Makes the player stop and think What Makes a Puzzle Good? What Makes a Puzzle Good? Fun. …from Challenge: ● The player feels a sense of trust and respect from the designer ●The player is invited to find a solution, not be handed one ●The solution is attainable ● The player feels a sense of accomplishment upon completion What Makes a Puzzle Good? Learning is Fun Precision of Emotion: A New Kind of "Fun" Approach Erin Hoffman, GDC 2015 Sophia: Emotion of Mastery FEAR SURPRISE HAPPINESS created by an Curiosity Speculation Stress of mastery absence of skill Discovery Insight Puzzle MASTERY = finding INSIGHT ●Click to edit Master text styles ● Second level ●Third level ●Fourth level ●Fifth level ●Click to edit Master text styles ● Second level ●Third level ●Fourth level ●Fifth level ●Click to edit Master text styles ● Second level ●Third level ●Fourth level ●Fifth level ●Click to edit Master text -
Mega-Structures of the Middle Ages: the Construction of Religious Buildings in Europe and Asia, C.1000-1500
Mega-Structures of the Middle Ages: The Construction of Religious Buildings in Europe and Asia, c.1000-1500 Maarten Prak Utrecht University [email protected] Abstract: How did medieval builders manage to construct Gothic cathedrals—buildings which are still among the tallest structures in the world—without access to the modern engineering theories? The paper investigates medieval building knowledge and the way it was transferred across the generations. Printed information only seems to have emerged in the course of the 15th century. Construction drawings were limited to details. By implication, the relevant knowledge must have been transferred on a personal basis. Its underlying principles therefore must have been reasonably simple. The paper attempts to demonstrate that a modular design and execution was underpinning much of the construction work on large projects such as European cathedrals. By briefly considering building projects in the Middle East and Asia, it also suggests that this was probably true throughout Eurasia. 1 Introduction In the medieval Latin West1, building must have been among the most important industries, constituting perhaps as much as five percent of the economy. Between 1136—when building started on the new choir for the church of Saint Denis, north of Paris, presumably the first Gothic project—and the middle of the fourteenth century, medieval Europe was in the grip of what amounted to a building boom. Major projects continued to be undertaken in the following centuries. The products of this boom still amaze observers today. In many European towns the cathedral and other medieval churches are among the main tourist sights and keep attracting crowds of visitors who travel long distances to admire them.