Associations between adult height and type 2 diabetes mellitus– a systematic review and meta-analysis of observational studies
Sarita Shrestha (SS)1 Sara H Rasmussen (SHR)1 Anton Pottegaard (AP)2 Lars H Ängquist
(LHÄ)1 Tine Jess (TJ)1 Kristine H Allin (KA)1,3 Lise G Bjerregaard (LGB)1 Jennifer L
Baker (JLB)1,3
1Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital,
Hovedvejen 5, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark.
2Clinical Pharmacology and Pharmacy, Department of Public Health, University of
Southern Denmark, DK-5000 Odense C, Denmark
3Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic
Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Correspondence: Dr. Jennifer L. Baker, Center for Clinical Research and Prevention,
Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark.
Phone: (+45) 38163058 Fax +45 3816 3119 Email: [email protected]
Supplementary table 1: Search logs and search strings
Date of Resources String Search terms/Strategies #Hits/ Search Used Results (database, search engine) 9 May PubMed string 1 (((((((((body height) OR height) OR human height) OR Stature) 5,479 2018 OR Waist to Height Ratio) OR Waist to Stature Ratio)))) AND ((Association) OR Risk OR Cohort Studies) AND ((((((((((((Diabetes Mellitus, Type 2) OR Insulin Resistance) OR Insulin Sensitivity) OR Impaired Glucose Tolerance) OR Glucose Intolerance) OR Glycemic Load) OR Insulin) OR Plasma Insulin) OR Serum Insulin) OR HbA1c) OR Glycosylated Hemoglobin) OR Glucose OR Blood Glucose) 10 May Embase strin "body height".mp or height.mp or stature.mp or "waist to height 2,404 2018 g 1- ratio".mp or "waist to stature ratio".mp and risk.mp or "cohort free- studies".mp and association.mp or relationship.mp and "non- text insulin-dependent- diabetes".mp or "type 2 diabetes mellitus".mp or "glucose intolerance".mp or hyperglycemia.mp or "insulin resistance".mp or "insulin sensitivity".mp or insulin or "impaired glucose tolerance".mp or "blood glucose level".mp or "insulin glucose level".mp or "glycemic load".mp or hemoglobin A1c.mp 20 May Embase string- 2 Body height and non-insulin-dependent-diabetes/or oral glucose 5,337 2018 map tolerance test/ or glucose intolerance/ or hyperglycemia/or insulin term to resistance/or glucose tolerance/ or insulin/ or insulin sensitivity/ or subject glucose blood level/ or insulin blood level/or glycemic load/or heading- hemoglobin A1c/ or impaired glucose tolerance Emtree term 16 May Google string 1 Height "leg length" AND "Type 2 Diabetes Mellitus" insulin 261 2018 Scholar resistance" "Incidence" "Prevalence" "Risk"
16 May Google string 2 Height "stature" AND "Associations" "Risk" AND "Type 2 2,100 2018 Scholar Diabetes Mellitus" “Insulin resistance” and "type 2 diabetes"
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Grey Literature databases
16 May OpenGrey height and type 2 diabetes 3 2018
16 May Worldcat. ti: Height ti: Type 2 diabetes 82 2018 org
21 May, CINHAL TX height AND TX type 2 diabetes (related words applied while 302 searching) 2018
Snowballing 3 strategy
Total studies from all databases and other sources 15,971
Total studies screened 10,356
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Supplementary Figure 1. Forest plot of the associations between adult height and T2DM by sex. ES denotes effect size.
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Supplementary Figure 2. Forest plot of the associations between adult height and ‘only T2DM’ and ‘mostly T2DM’ respectively. M indicates men, W indicates women, and M/W indicates men and women. ES denotes effect size.
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Supplementary Figure 3. Forest plot of the associations between adult height and T2DM in studies reporting odds ratios, relative risk estimates or hazard ratios. M indicates men, W indicates women, and M/W indicates men and women. ES denotes effect size.
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Supplementary Figure 4. Forest plot of the associations between adult height and T2DM in cross-sectional studies and cohort studies. M indicates men, W indicates women, and M/W indicates men and women. ES denotes effect size.
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Supplementary Figure 5. Forest plot of the associations between adult height and T2DM in studies analysing height as a continuous effect or height in categories. M indicates men, W indicates women, and M/W indicates men and women. ES denotes effect size.
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