CACNB4 Antibody Cat. No.: 28-224

CACNB4 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human CACNB4.

TESTED APPLICATIONS: ELISA, WB

CACNB4 antibody can be used for detection of CACNB4 by ELISA at 1:312500. CACNB4 APPLICATIONS: antibody can be used for detection of CACNB4 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

POSITIVE CONTROL: 1) Cat. No. 1205 - Jurkat Cell Lysate

PREDICTED MOLECULAR 55 kDa WEIGHT:

Properties

PURIFICATION: Antibody is purified by peptide affinity chromatography method.

CLONALITY: Polyclonal

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

October 1, 2021 1 https://www.prosci-inc.com/cacnb4-antibody-28-224.html Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose.

CONCENTRATION: batch dependent

For short periods of storage (days) store at 4˚C. For longer periods of storage, store STORAGE CONDITIONS: CACNB4 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

Additional Info

OFFICIAL SYMBOL: CACNB4

ALTERNATE NAMES: CACNB4, CAB4, CACNLB4, EA5, EJM, EIG9, EJM4, EJM6

ACCESSION NO.: NP_001005747

PROTEIN GI NO.: 54607068

GENE ID: 785

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

CACNB4 is a member of the beta subunit family, a in the voltage-dependent complex. CACNB4 plays an important role in calcium channel function by modulating inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. This encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of BACKGROUND: each of these subunits exist, either expressed from similar or the result of . The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

REFERENCES: 1) Kobayashi, T., (2007) Biochem. Biophys. Res. Commun. 360 (3), 679-683.

ANTIBODIES FOR RESEARCH USE ONLY.

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