grape bubblegum and peppermint flavour. Please do not stop fosamprenavir without FOSAMPRENAVIR Shake the bottle well before taking your dose. talking to your doctor first. This suspension should be taken without food

 on an empty stomach. Other NAMES: Telzir What ADVERSE EFFECTS can this drug cause? What should you do about them? WHY is this drug prescribed? Fosamprenavir tablets can be taken with or without food. The most common side effects people report Fosamprenavir is an antiretroviral (anti-HIV) with fosamprenavir include stomach upset, gas, Your dosage is: drug that belongs to a class of drugs called abdominal pain, diarrhea and vomiting If you get a headache, this can usually be controlled with protease inhibitors . Protease inhibitors ____tablets (____mg) ____ times a day + interfere with a different step in virus non-prescription drugs, such as acetaminophen (Tylenol ). reproduction than other classes of drugs ____ ritonavir (___mg) ___times a day, OR previously available to fight HIV. Fosamprenavir Other side effects that may occur are tiredness is used together with other antiretrovirals 50 mg / mL oral suspension (usually in combination with ritonavir) to delay and an increase in cholesterol in the blood . the progression of HIV infection. By doing this, ____mL (____mg) ____ times a day + People have complained about skin rashes, but your immune system should improve (increase in most cases this effect goes away on its own, in CD4 + count) and you will be better protected ____ ritonavir (____mg) ____times a day without having to stop treatment. Severe rashes against infections. have rarely been reported. Tell your doctor if Swallow tablets whole with some water or non- you have an allergy to sulphonamides. If these Fosamprenavir does not cure AIDS or alcoholic drink. effects occur and are bothersome, please call completely kill the HIV virus, but helps to the clinic or discuss them at your next visit. Avoid drinking excessive amounts of alcohol prevent further damage by slowing down the Regular blood tests will be done to detect any while you are taking fosamprenavir tablets. If production of new viruses. Treatment with changes in your liver or pancreas function. Also, you are taking fosamprenavir suspension, it is fosamprenavir does not reduce the risk of your doctor will look for increases in your best to completely avoid alcoholic beverages. passing infection on to others. You will still be cholesterol, triglyceride and blood sugar level. able to pass HIV by sexual contact, by blood transfer or by sharing needles. You should What should you do if you FORGET a dose? The long-term effects of fosamprenavir are always use appropriate precautions to prevent If you miss a dose of fosamprenavir, take it as unknown at this time. Further studies are being passing HIV on to others. soon as possible. However, if it is time for your carried out. Abnormal weight gain or changes in next dose, do not double the dose, just carry on body shape have been reported, but it is HOW should this drug be taken? with your regular schedule. uncertain if fosamprenavir is responsible for these changes. Fosamprenavir is available as a 700 mg film- coated tablet , so it is more easily swallowed Why should you not forget to take this drug? It is important that you keep your doctor and an oral suspension containing 50 mg/mL If you miss doses of fosamprenavir, the amount appointments and come for your laboratory of active drug. The dose of fosamprenavir of HIV virus in your blood (known as the viral tests so that your progress can be followed. 1400mg (2 x 700 mg tablets) in combination load) will start increasing again and your with ritonavir 200 mg (2 x 100 mg) may be immune system will be further damaged. A few What other PRECAUTIONS should you taken once daily or divided into two doses missed doses can be enough for fosamprenavir follow while using this drug? every 12 hours. This dose may need to be to stop being active. When this happens, it is You must make sure that you are taking the adjusted if you are taking other protease known as resistance. Other antiretrovirals that right dose. If you take higher doses of inhibitors or to meet your particular needs. work in a similar way as fosamprenavir may fosamprenavir than what is prescribed, you may also become inactive. Therefore, missing doses increase the chance of having adverse effects. Fosamprenavir is also available as an oral 50 of fosamprenavir can cut down treatment If you take lower doses of fosamprenavir than mg/mL suspension for patients who cannot choices for the future. swallow the tablets. The liquid is off-white with a what is prescribed, the HIV virus may become to your baby. Breastfeeding is NOT resistant to amprenavir. recommended if you have HIV as you can transmit the virus to your baby through your Certain drugs can increase or decrease the breast milk. effect of fosamprenavir. Also, fosamprenavir might influence the effect of other drugs you are How should this drug be STORED? taking. Inform your doctor and pharmacist of all Fosamprenavir tablets should be stored prescribed, non-prescribed drugs, herbals and between 15 – 30 °C and the oral suspension FOSAMPRENAVIR nutritional supplements you are taking. As well, between 2 – 30 °C. Keep the tablets in a dry you should inform them of natural products you place, protected from light. Do not allow the are taking. If you wish to start a new drug or suspension to freeze. Keep medication well out natural product, please consult with your of the reach of children. Ensure that the drug pharmacist before doing so. has not expired by checking the expiry date (“EXP”) shown on the outside of the package. Do NOT take the following medications with The suspension has a shelf life of 28 days from MEDICATION fosamprenavir: the time it is dispensed (the pharmacist will put Diazepam (Valium ) that date on the side of the bottle). Ergot derivatives [Ergotamine (Cafergot , Bellergal , Ergodryl , Gravergol ), Do not store in your bathroom, as heat and FACT SHEET ergonovine, dihydroergotamine (Migranal ), moisture may cause the drug to be less active. methylergonovine (Methergine)] If you have any questions or concerns about this Flecainide (Tambacor ) drug or if you are experiencing adverse effects, Flurazepam please discuss them with your pharmacist, Midazolam (Versed ) doctor or nurse. Write questions or concerns Pimozide (Orap ) down to ensure they are addressed. Propafenone (Rhythmol ) Rifampin (e.g. Rifadin , Rimactane , If you have any questions or concerns about Rofact ) this drug or if you are experiencing adverse St. John’s Wort effects, please discuss them with your Triazolam (Halcion ) pharmacist, doctor or nurse. Write questions or concerns down to ensure they The efficacy of birth control pills or other are addressed. hormones used to prevent becoming pregnant may be decreased if you are taking The following pharmacist is available to answer fosamprenavir. A second method of questions: contraception should always be used. In general, even if you are not taking Pharmacist: ______fosamprenavir, the use of condoms is always Telephone: ______recommended to decrease the risk of passing HIV on to others. Reference: Product monograph Telzir  (fosamprenavir). Saint-Laurent, Qc, Canada: GlaxoSmithKline, 2009. The safety of fosamprenavir tablets has not Prepared by the Ontario HIV Pharmacy Professional been established during pregnancy. Please Specialty Group, 2005. Reviewed 2009. inform your doctor if you are pregnant. Your Additional medication fact sheets and updates may be doctor can recommend the right treatment to found at: www.hivclinic.ca help reduce the risk of passing the HIV virus on