RAMNIK XAVIER is a core institute member of the of MIT Ramnik and Harvard and co-director of the Xavier, M.D. Broad’s Infectious Disease and Microbiome Program. He is the Kurt Isselbacher Core Institute Member Professor of Medicine at Harvard Medical of the Broad Institute School; director of the Center for of MIT and Harvard Computational and Integrative Biology and member of the Department Co-Director of the Infectious of Molecular Biology at General Hospital (MGH); and Disease and Microbiome co-director of the Center for Microbiome Informatics and Therapeutics Program of the Broad at MIT. Institute of MIT and Harvard As a clinical gastroenterologist and molecular biologist, Xavier studies the Core Faculty Member in the specific molecular mechanisms involved in innate and adaptive immunity Department of Molecular as well as the genetic variants associated with Crohn’s disease, ulcerative Biology and Director of the colitis, and autoimmunity. By determining the physiological functions of Center for Computational inflammatory bowel disease (IBD)-associated polymorphisms, his work and Integrative Biology at illuminates processes underlying mucosal homeostasis and inflammation. Massachusetts General Using human cohorts, the laboratory interrogates the microbiome’s Hospital impact on immunity and inflammation. Recent studies demonstrated Kurt Isselbacher Chair in that microbiome variability influences cytokine production and associated Medicine and Professor at microbiome variation with autoimmunity risk, pinpointing microbial Harvard structures likely mediating susceptibility. Through a transformative collaboration with the Broad’s Chemical Biology and Therapeutic Sciences Co-Director of the Center Program, the laboratory aims to discover small molecules that can correct for Microbiome Informatics pathways defective in Crohn’s disease and autoimmunity. and Therapeutics at MIT

At the Broad, Xavier will focus on expanding research efforts in immunol- ogy and promoting investigations of fundamental questions in human disease biology. These efforts will define the immune processes that play a central role in both healthy and disease states, and will complement existing programs at the Broad that focus on conditions with a strong immunologic basis, for example, programs aimed at cancer biology, neurodegenerative and psychiatric conditions, medical and population genetics, and infectious disease.

Ramnik has spent his academic career at MGH serving as chief of gastroenterology and director of the Center for the Study of Inflammatory Bowel Disease at MGH.

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