Risk Assessment Guidance for Enzyme-Containing Products The Soap and Detergent Association Table of Contents Preface 2 Executive Summary 3 Chapter 1 — Introduction to Enzymes 4 Chapter 2 — Introduction to Risk Assessment 6 Chapter 3 — Hazard Identification 8 Chapter 4 — Dose-Response Assessment 11 Chapter 5 — Exposure Assessment 17 Chapter 6 — Risk Characterization 23 Chapter 7 — Risk Management 28 Chapter 8 — Conclusions 30 Bibliography 31 Glossary 38 Appendix 1 — Estimation of Exposure to Enzymes from Early Detergent Formulations 41 Appendix 2 — Enzyme Risk Assessments of Hand-Laundering Practices 51 Appendix 3 — Spray Pre-Treater Case Study 54 FIGURES — 1, 2, 3 A, 3 B, 4 TABLE — 1 Copyright © 2005:The Soap and Detergent Association. Al rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any infor- mation storage retrieval system, without written permission from the publisher. For information, contact:The Soap and Detergent Association, 1500 K Street, NW, Suite 300,Washington, DC 20005, USA. Telephone: +1-202-347-2900. Fax: +1-202-347-4110. Email:
[email protected]. Web: www.sdahq.org PREFACE he laundry product industry has implemented For additional information on risk assessment and Ta successful product stewardship program to risk practices for enzymes, contact your enzyme promote the safe use of enzymes in the workplace supplier, or and by users of their products,using both appropriate risk assessment and risk management practices. The Soap and Detergent Association Much of the information about enzymes for laundry 1500 K Street, NW, Suite 300 applications can be applied to other finished products Washington, DC 20005 including those in the cleaning and personal care Tel: 202-347-2900 markets.