Efficacy of the Taylor Spatial Frame in the Treatment of Deformities Around the Knee
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The Effect of Cytotoxic Chemotherapy on the Structural and Material Properties of Regenerate Bone in a Rabbit Model of Limb Lengthening
The Effect of Cytotoxic Chemotherapy on the Structural and Material Properties of Regenerate Bone in a Rabbit Model of Limb Lengthening Fergal Monsell PhD Thesis University College London 2010 Table of Contents p.6 Declaration p.7 Acknowledgments p.8 Abstract Section 1 Osteogenic Sarcoma; Historical Perspectives, Current Concepts and the Aim of This Work p.10 1.1 Introduction p.11 1.2 Osteogenic sarcoma p.13 1.3 Multi-agent Chemotherapy in the Management of Osteogenic Sarcoma p.14 1.3.1 cis-Platinum and Adriamycin in the Treatment of Osteogenic Sarcoma p.15 1.3.2 cis-Platinum Pharmacology p.16 1.3.3 Side Effects of cis-Platinum p.17 1.3.4 Adriamycin Pharmacology p.18 1.3.5 Side Effects of Adriamycin p.18 1.3.6 Overview of the Role of Chemotherapy in the Management of Osteogenic Sarcoma p.19 1.4 Surgical Management of Osteogenic Sarcoma in Childhood p.19 1.4.1 Historical Perspective p.20 1.4.2 Allograft Reconstruction p.22 1.4.3 Vascularised Fibular Graft Reconstruction p.23 1.4.4 Rotationplasty p.24 1.4.5 Endoprosthetic Reconstruction p.24 1.4.6 Expandable Endoprosthetic Reconstruction p.25 1.4.7 Overview of the Surgical Management of Osteogenic Sarcoma p.26 1.5 Distraction Osteogenesis p.27 1.5.1 Historical Perspective p.27 1.5.2 The Biology of Distraction Osteogenesis p.29 1.6 Bone Transport p.29 1.6.1 Bone Transport for Traumatic Defects p.31 1.6.2 Bone Transport Following Benign Tumour Excision p.31 1.6.3 Bone Transport Following Malignant Tumour Excision p.32 1.6.4 Bone Transport in the Management of Ewing’s and Osteogenic Sarcoma -
Dynamization of Simple Fractures with Active Locking Plates Delivers (P
9400 West Higgins Road, Suite 305 Rosemont, IL 60018-4975 Phone: (847) 698-1631 FAX: (847) 430-5140 E-mail: [email protected] Welcome to the Orthopaedic Trauma Association’s (OTA) 32nd Annual Meeting! The Program Committee, under the leadership of Bob O’Toole and Mike McKee have created an outstanding program that includes cutting edge clinical and basic research from around the world. The quality of scientific sessions is evidenced by the observation that one quarter of all podium presentations this year are reporting on prospective randomized trials. Each Steven A. Olson, MD attendee can benefit from this year’s Annual Meeting in some way, and I encourage you to carefully review the program and select a track that best suits your needs. As our organization has grown so have the opportunities for attendees to take advantage of. These include the Basic Science Focus Forum, International Forum, OTA Grant Writing Workshop, Orthopaedic Trauma for PA & NPs and a plethora of full and mini-symposia, including Industry and Health policy symposia. Additionally, the Annual Meeting will offer an unprecedented number of opportunities to network and interact with friends and colleagues. This year’s venue at the Gaylord National Hotel & Convention Center is exceptional. There are social events every evening: the international reception on Wednesday, the welcome reception and fund raising auction on Thursday at the Gaylord National, and “suds and science” guided poster tours with beer and wine in the exhibit hall on Friday evening. Please also join me in extending a special welcome to our guest nation attendees from India, international attendees, and SIGN scholars from Kenya and the Philippines. -
Always Innovating, Never Imitating
Always innovating, never imitating In over 20 years of clinical use, TAYLOR SPATIAL FRAME has been used to treat more than 132,000 patients with deformity or traumatic injury in over 50 countries around the world. 95% success rate in acute trauma1 91% of patients with non-union or malunion achieved union1 86% of patients did not require further surgery for complications1 Adults Johnnie O. Yellock II, Combat Veteran* TAYLOR SPATIAL FRAME◊ External Fixator Orthopaedic Surgeon J. Charles Taylor collaborated 1996 ◊ with Smith+Nephew to develop the TAYLOR SPATIAL FRAME (TSF ) External Fixator. Dr. Taylor took mathematical algorithms already employed by the aerospace and automotive industries, and married them to Professor Ilizarov’s principles of Distraction Osteogenesis to produce the first-of-its-kind hexapod for limb reconstruction. The TSF construct is two rings attached to bone and connected by six telescoping struts. A prescription for strut adjustment is generated by web-based software allowing correction of deformity in six axes simultaneously, and achieving reduction to within 1mm and 1º. More than Every year we connect Smith+Nephew has led the education of orthopaedic surgeons in circular fixation 200 500 since the first trip to Kurgan in clinical publications reference surgeons around the world TAYLOR SPATIAL FRAME1 with master faculty at our industry-leading 1988 instructional courses We help you push the boundaries in limb restoration and allow your patients to rediscover the joy of Life Unlimited. 2 TAYLOR SPATIAL FRAME External Fixator Adult Brochure TAYLOR SPATIAL FRAME◊ External Fixator is the most widely 95% success rate 91% of patients 86% of patients In over 20 years of clinical in acute trauma1 achieved non-union or were managed use, TSF has been used to used hexapod malunion consolidation1 without need for treat more than 132,000 further surgery1 patients with deformity or in the world. -
The Benefits and Risks of the Ilizarov Technique for Limb Reconstruction
1 Rebecca Littlewood THE BENEFITS AND RISKS OF THE ILIZAROV TECHNIQUE FOR LIMB RECONSTRUCTION Introduction In the past, patients with fractures which failed to heal (non‐union), or healed incorrectly (mal‐ union) had little treatment available to them, and patients who required surgical removal of infected bone (osteomyelitis) or cancerous bone often had no choice but to have an amputation of the affected limb. The treatment of such orthopaedic conditions was revolutionised by Dr Gavril Ilizarov, as will be explained below. The Ilizarov frame takes its name from Dr Gavril Abramovich Ilizarov. He was born in the Soviet Union in 1921 and attended medical school in Crimea aged 18. Having graduated in 1944, his first job was as a family doctor in the Kurgan province of Northern Siberia. As this was a remote area, Ilizarov worked largely alone, and was required to perform a range of surgical procedures. As there were no experienced physicians available to guide him, he taught himself many surgical techniques from books as his only formal surgical training had been a six month course in military field surgery. Ilizarov first became interested in orthopaedics and bone reconstruction because many of his patients were soldiers returning from the front line battles of World War 2. Many of the patients suffered severe fractures, and had to endure lengthy treatment; casts and skeletal traction being the only methods generally used (Ilizarov & Rozbruch, 2007). Ilizarov believed there must be other ways of treating fractures, and devoted his career to orthopaedics. In 1950, Ilizarov moved to Kurgan where he worked within the general surgery department at the Kurgan regional hospital.