Anti-ERO1L (Aa 37-189) Polyclonal Antibody (DPABH-02159) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-ERO1L (aa 37-189) polyclonal antibody (DPABH-02159) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. Required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin.

Immunogen Recombinant fragment, corresponding to amino acids 37-189 of Human ERO1L (BC008674).

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB, IHC-P

Format Liquid

Size 100 μg

Buffer pH: 7.20; Constituents: 98% PBS, 1% BSA

Preservative 0.02% Sodium Azide

Storage Shipped at 4°C. Store at -20℃.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol ERO1L

Synonyms ERO1L; ERO1-like (S. cerevisiae); ERO1 (S. cerevisiae) like; ERO1-like protein alpha; ERO1 alpha; ERO1A; ERO1-L; ERO1-L-alpha; oxidoreductin-1-L-alpha; endoplasmic oxidoreductin-1- like protein; ERO1-alpha;

Entrez Gene ID 30001

Protein Refseq NP_055399

UniProt ID Q96HE7

Chromosome Location 14q22.1

Pathway Diabetes pathways; Disease; Insulin Synthesis and Processing; Protein processing in endoplasmic reticulum; Vibrio cholerae infection;

Function flavin adenine dinucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]