CURRICULUM VITAE

F. Jon Kull, Ph.D.

Department of Chemistry tel: 603-646-1552 Dartmouth College fax: 603-646-3946 Hanover, NH, 03755, USA [email protected]

Education:

September 1989 – June 1996 Ph.D. in Biochemistry Department of Biochemistry and Biophysics University of California San Francisco San Francisco, California, USA

September 1984 – June 1988 A.B. Magna cum Laude Phi Beta Kappa Dartmouth College Hanover, , USA Majors: Chemistry with High Honors Biology

Academic Positions:

July 2016 – present Dean of the School of Graduate and Advanced Studies Dartmouth College Hanover, NH, USA

July 2012 – present The Rodgers Professor at Dartmouth College Dartmouth College

July 2012 – present Professor Department of Chemistry Dartmouth College

August 2012 – June 2016 Dean of Graduate Studies Dartmouth College

July 2007 – July 2012 Associate Professor Department of Chemistry Dartmouth College

July 2001 – June 2007 Assistant Professor Department of Chemistry Dartmouth College

January 2000 – December 2001 Research Group Leader (C3) Max-Planck Institute for Medical Research Max-Planck-Gesellschaft Heidelberg, Germany

January 1998 – December 1999 Research Group Leader (BAT 1B) Department of Biophysics Max-Planck Institute for Medical Research Heidelberg, Germany

July 1997 – December 1997 Postdoctoral Fellow Prof. Ronald Vale Howard Hughes Medical Institute San Francisco, California, USA

March 1997 – June 1997 Visiting Assistant Professor of Chemistry Dartmouth College Department of Chemistry

June 1996 – February 1997 Postdoctoral Fellow Prof. Robert Fletterick and Prof. Ron Vale Department of Biochemistry and Biophysics University of California San Francisco

September 1989 – June 1996 Graduate Student Prof. Robert Fletterick Department of Biochemistry and Biophysics University of California San Francisco Research Experience:

September 1987 – June 1988 Undergraduate Honors Thesis Prof. Dean Wilcox Department of Chemistry Dartmouth College Hanover, New Hampshire

Honors and Awards:

2012 – The Rodgers Professor at Dartmouth College, Endowed Chair 2012 – Dartmouth Center for the Advancement of Learning Faculty Fellow 2011 – Gridley Faculty Fellow 2010 – Dean of the Faculty Award for Outstanding Mentoring and Advising 2007 – Linda B. and Kendrick R. Wilson III Fellow 2006 – Named ‘Education Fellow in the Life Sciences’ by the National Academies 2003 – March of Dimes Basil O'Connor Starter Scholar Research Award

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Dean of the School of Graduate and Advanced Studies:

Establishing the School of Graduate and Advanced Studies at Dartmouth: • From October 2014 through June 2015, as Dean of Graduate Studies, I chaired a 12-member faculty task force, formed by the Provost, to shape the transition from an Office of Graduate Studies housed in, and reporting to Arts & Sciences, to an independent School of Graduate and Advanced Studies reporting to the Provost. The resulting report formed the foundation of the new school, the first to be established at Dartmouth in over a century, which was approved by Dartmouth’s Board of Trustees on January 27th, 2016. I was appointed as the inaugural Dean of the School on July 1st, 2016. Key Responsibilities: • Oversight of Dartmouth’s 16 Ph.D. and 12 Master’s programs (over 850 students), including: admissions and financial aid, registrar, program oversight, fellowship support, recruiting, communications, outreach, alumni relations, development, student support, academic and nonacademic misconduct, program reviews, and granting all Ph.D., M.S., and M.A. degrees. • Judicial oversight over an additional 200 students in the master in Engineering Management and Master in Public Health programs, whose degrees are granted by the Thayer School of Engineering and the Geisel School of Medicine, respectively. • Support Dartmouth’s ~230 postdoctoral fellows. I am currently searching for an Assistant Dean for Postdoctoral Affairs to formalize support and professional development for this group of scholars. • Budget, including tuition and financial aid, of $44.8 million, including an operating budget of $8.6M. • Oversee staff of 10 working in the GRAD office (there are 25 staff in the GRAD organization, but 15 of these work in the Master of Liberal Studies and master of Health Care Delivery Science programs, which are, for all intents and purposes, administratively and financially independent). • Chair the Council on Graduate Studies, a Dartmouth-wide faculty committee, the purpose of which is to recommend to the Dean of Graduate and Advanced Studies, the Provost, and the Trustees principles and policies governing all aspects of graduate education. Meetings and committees: • As a senior officer of the College, I attend most meetings/sessions of Dartmouth’s Board of Trustees. • As a School Dean, I am a nonvoting member of the Board of Trustees Academic Affairs Committee. • Once a month, Deans of GRAD, Engineering, Medicine, and Business Schools join the President’s weekly check-in meeting, which includes all officers directly reporting to the President (except for the A&S Dean, the School Deans report to the Provost) to discuss institutional policies and issues. • Along with other School Deans and Vice-provosts, attend the weekly “Deans meeting” convened by the Provost to discuss institutional policies and issues. • Quarterly Provost Academic Affairs committee, which has oversight over all academic programs. • Monthly Budget Committee, which recommends policies with respect to Dartmouth’s budget. • Weekly meetings of the Arts & Sciences Deans group, led by the A&S Dean of the Faculty, with Associate Deans of the Sciences, Social Sciences, Programs, and Arts & Humanities, to discuss policies and issues related to the of Arts & Sciences, which instructs Dartmouth’s undergraduates. • Quarterly meetings as a non-voting guest of the Committee or Chairs of the 40 Arts & Sciences Departments.

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Research Support:

ACTIVE

R01 AI120068 (Kull & Skorupski, multi-PI) 7/1/16 – 6/30/21 NIH/National Institute of Allergy and Infectious Diseases $288,444 direct cost, annual Control of Virulence in Vibrio cholera by Fatty Acids The long-term objectives of the work in this proposal are to elucidate the complex mechanisms by which Vibrio cholerae regulates the expression of its virulence genes so that better strategies can be developed to control cholera and possibly other enteric bacterial infections.

P20 GM113132-01A1 (Madden PI; Kull, Core B co-director) 05/15/16 – 2/28/21 NIH/NIGMS $1,800,000 direct cost, annual iTarget: Institute for Biomolecular Targeting This proposal established a new Center of Biomedical Research Excellence (COBRE) in Biomolecular Targeting at Dartmouth.

R01 AI072661-05 (KULL) 12/15/2006 – 3/31/2018 NIH/NIAID $229,167 direct cost, annual Structural analysis of Vibrio cholerae virulence gene regulatory proteins The major goal of this project is to structurally and biochemically characterize the major virulence factor regulators in the pathogenic bacterium Vibrio cholera.

COMPLETED

R01 GM097079-01 (KULL) 4/1/2011 – 3/31/2016 NIH/NIGMS $300,200 annual, direct plus indirect Fine tuning the catalytic cycle of kinesin motors

R21 AI092161-01 (KULL) 9/30/2011 – 8/31/2013 NIH/NIAID $237,000 annual, direct plus indirect Fatty acid related regulation of enteric infectious disease

R01 GM066913 (KULL) 7/01/03 – 6/30/10 NIH/NIGMS $265,000 annual, direct plus indirect Structural Characterization of Dynamin GTPases

0330345N (KULL) 01/01/03 – 12/31/06 American Heart Association Scientist Development Grant $260,000 total Structural and Biophysical Characterization of Conventional and Unconventional Myosins

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1 R21 AI060031 (KULL) 09/30/04 – 08/31/06 NIH/National Institute of Allergy and Infectious Diseases $316,000 annual, direct plus indirect Structural Analysis of Bacterial Virulence Regulators

5-FY02-256 (KULL) 2/01/03 – 01/31/06 March of Dimes Basil O'Connor Starter Scholar Research Award $150,000 total High-Resolution Structure Determination of a Class VII Myosin: Examining Its Role in Congenital Sensorineural Hearing Loss, Including Usher Syndrome Type 1B and Other Forms of Human Hereditary Deafness

03/99 – 06/02 Deutsche Forschungsgemeinschaft (DFG) Program Project Grant Molecular Motors

Postdoctoral, Graduate and Undergraduate Research/Advising/Training:

Research associates: Charles Midgett, Ph.D. (2013 – present) Research associates (past): Anita Prasad, Ph.D. (2004 – 2015) Postdoctoral Fellows (past): Jared Cochran, Ph.D. (2006 – 2011) now Assistant Professor, University, Bloomington Received an NIH Ruth L. Kirschstein National Research Service Award (2007 – 2009) Graduate Students: Students in my group (present) Anne Woodbrey née Kelley (Chemistry, 2014-present) Justin Cruite (MCB, 2012 – present) Britney Privett née Tappen (Chemistry (2011 – present) Jessica Day (MCB, 2010 – present)

Students in my group (past) Ryan Tibble, M.S. Chemistry 2015 Qian Li, M.S. Chemistry 2015 Wei Shi, Ph.D. Chemistry 2015 Jennifer L. Taylor, Ph.D. Chemistry 2012 Morgan Thompson, Ph.D. Biochemistry 2012 Kim Peaslee, Ph.D. Chemistry 2009 Samantha Desmarais, Ph.D. Chemistry 2009 Rukman De Silva, Ph.D. Chemistry 2007 Mary Reid, M.S. Chemistry 2006

Thesis committee member (students not in my group, present) Kelsie Leary, Chemistry

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Alejandro Gil, Chemistry Jiaxue Ma, Chemistry

Thesis committee member (students not in my group, past) Yang Gao, Ph.D. 2016 (MCB) Jeremy Fitzpatrick, Ph.D. 2015 (Chemistry) Joshua Weiner, Ph.D. 2014 (MCB) Samantha Reynolds, Ph.D. 2012 (Chemistry) Swapna Kollu, Ph.D. 2010 (MCB) Jolene Schuster, Ph.D. 2009 (Chemistry, co-advisor) Charles Midgett, Ph.D. 2008 (MCB) Avinash Gill, Ph.D. 2008 (MCB) Sujata Roy, Ph.D. 2007 (Chemistry) Veljko Popov, Ph.D. 2006 (Chemistry) Roman Laritchev, Ph.D. 2006 (Chemistry) Matthew Cheney, Ph.D. 2006 (MCB) Brian Stevens, Ph.D. 2006 (MCB) Callie Schieffer, M.S. 2004 (Chemistry) Pavle Milutinovic, M.S. 2005 (Chemistry) Jiying Lu (Chemistry, left program)

MCB Rotation Students Muhammad A. Khan (W17) Justin Cruite (S13) Jessica Day (F09) Wei Shi (X09) Morgan Thompson (S06) Chris Bahl (F06) Swapna Kollu (W05) Matthew Cheney (F02)

Undergraduate students: Current Kenzie Clark ’17 (9 terms, WISP, Presidential Scholar, Honors Thesis)

Past (honors theses, interns, fellows, or Chem87 credit) Irina Shlosman ’16 (9 terms, WISP, Presidential Scholar, Honors Thesis) Adam Sanford ’13 (6 terms) Zachary J. Myslinski ’14 (6 terms, sophomore science, Presidential Scholar, Honors Thesis) Ryan Tibble ’14 (9 terms, HHMI, Presidential Scholar, Honors Thesis) Alexandra Geanacopoulos ‘13 (9 terms, WISP, HHMI, Presidential Scholar, Honors Thesis) Kiko Lam ’14 (2 terms, WISP, co-advisor) Jaya Batra ‘13 (2 terms, WISP) Anne Kelly (2 terms, INBRE intern from Plymouth State) John Dalton ’12 (1 term) Mary Tate ‘12 (3 terms, Presidential Scholar) Brenna Gibbons ’12 (3 terms, Presidential Scholar ) Ming Lee ’11 (5 terms, Honors Thesis, Zabrieske Fellow) Julia Kiernan ’11 (8 terms, Chem 87 Thesis) Rebecca Glover ’11 (2 terms, WISP) Stephanie Siegmund ’10 (3 terms, Honors Thesis, Zabrieske Fellow)

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Yu Cheng Zhao '10 (9 terms, Presidential Scholar, Honors Thesis, Zabrieske Fellow) Landon Brown '10, (7 terms, HHMI, Presidential Scholar, Honors Thesis, Zabrieske Fellow) Emily M. Eichenberger ’09 (3 terms, HHMI) Roxana Mirica ’08 (6 terms, Presidential Scholar, Honors Thesis) Natsha Mulko ’07 (Honors Thesis, 3 terms) Katherine Brill ’06 (Honors Thesis, 6 terms) Diana Geisser ’06 (Honors Thesis, Zabrieske Fellow, AHA Award) (6 terms) Elisabeth F. Heuston ’06 (Honors Thesis, Zabrieske Fellow) (8 terms) Peter Chalmers ’05 (Chem 87 Thesis) Michale Lauria ’05 (Chem 87 Thesis) Meredith Hartley ’05 (Honors Thesis, Presidential Scholar, Zabrieske Fellow) Lavan Khandan ’04 (Chem 87 Thesis) Andy Fisher ’03 (Chem 87 Thesis) Sydney Lu ‘03 (Honors Thesis)

Senior fellows (past) Justin Altshuler ’06 (advisor/committee member) (3 terms)

Past (research or work study for one or more terms) Brenna Gibbons ’12 (3 terms) Michael Ciorazzo (SURF Summer Intern, 2009) Eui Suk Chung ’08 (1 term) Alex Pappas (SURF Summer Intern, 2007) Ameya Paradkar ’07 (Presidential Scholar, 2 terms) Kristin Lieske ’07 (Presidential Scholar, 2 terms) Michael Cianfrocco (SURF Summer Intern, 2006) Morgan Thompson (Boston University ’05, 1 term) Carolina Lin ‘05 Meredeth McGowan ‘04 Chad Dooley ‘04 Ako Takakura ‘04 Jonathan Werner-Allen ‘04 Rachel Wong ‘03

Teaching in the Dartmouth Chemistry Department: (terms indicated, numbers in parentheses indicate enrollments)

Chemistry 5 General Chemistry Part 1 Lecture only. F03 (co-taught, 111), F05 (101), W08 (102), F10 (88)

Chemistry 6 General Chemistry Part 2 Lecture only. S07 (82)

Biology/Chemistry 8, 9 Chemical Principles and Biological Processes I, II Lecture and lab. F11 (80) W12 (70); F12 (45) W13 (45); F13 (39) W14 (34) Notes: F11: Developed two-term course with Roger Sloboda (biology) with funding from the HHMI. Course combines material from introductory chemistry and biology and covers the principles and processes of general chemistry as applied to biochemistry and cell biology.

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Chemistry 41 Biological Chemistry Lecture and lab. S02 (42), S03 (31), S04 (37), S05 (50), S06 (lab only, 46), S07 (lab only, 38), S08 (61), S09 (35), S10 (44), S11 (41), S12 (37), S15 (67), S16 (36), S17 (TBD) Notes: S02: Developed and taught this course, an undergraduate biochemistry course for chemistry majors. Includes an eight-week lab utilizing techniques of molecular biology, protein expression, protein purification, and kinetic analysis.

Chemistry 45 The biophysical chemistry of biological motors and their filament tracks Co-taught. Lecture and lab. F08 (4), F09 (7) Notes: F08: Funded by an HHMI grant. With Roger Sloboda from Biology, developed and taught an interdisciplinary course focused on molecular motor proteins and filament tracks.

Chemistry 67 Physical Biochemistry W05 (co-taught, 17), W06 (lecture only, 17), W07 (lecture only, 12) Notes: W05: Developed several new lab modules. W06: Substantially reorganized the course to include primary literature discussion sections and student presentations.

Chemistry 161 Fall 2002 Special Topics in Advanced Biophysical Chemistry F02 (20 undergraduate, 5 graduate) Notes: F02: Developed and taught a graduate course focused on studying the detailed mechanisms of macromolecular protein complexes, and their related chemistry and biophysics.

Chemistry 264 Structural Biology Journal Club FWS08 – present (6-20 graduate students) Notes: Offered with other MCB faculty, each term we meet approximately four times and discuss papers with an emphasis on X-ray crystallography and/or structural biology.

Other Teaching at Dartmouth:

Mentoring Seminar Winter 2006, 2008, 2009 Notes: Offered with Roger Sloboda, a four-part seminar designed to help graduate students and postdocs become more effective mentors.

MCB Structural Biology Journal Club FWS 2004 – 2008 Notes: With other MCB faculty, each term we meet approximately four times and discuss papers with an emphasis on X-ray crystallography and/or structural biology.

Prior Teaching Experience:

Spring 1997 Dartmouth College Chemistry Department Chemistry 67 – Undergraduate Course in Physical Biochemistry

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Summer 1997 Teaching Assistant UCSF Department of Biochemistry and Biophysics Biochemistry 242 – Graduate Course in Protein Crystallography

October 1996 – February 1997 Scientific Consultant Science Education Partnership Program UCSF/San Francisco Unified School District

Winter 1993 Teaching Assistant UCSF Department of Biochemistry and Biophysics Biochemistry 201 – Graduate Course in Macromolecular Structure

Spring 1992 Teaching Assistant UCSF School of Medicine Interdepartmental Studies 100 Medical School Cell Biology

Meetings organized, co-organized, or committee member

Organizing committee member Biophysical Society Discussions – Molecular motors: Point Counterpoint October 2006, Asilomar, California

Academic Programs outside of the Chemistry Department:

Member, Graduate Program in Molecular and Cellular Biology (MCB) Member, Graduate Program in Biochemistry

Patents: Pending: US 20120157529 A1 Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection Granted: US 8741307 B2 Hybrid prokaryotic-eukaryotic tubulins and use thereof Consulting:

2004 Glycofi, Inc., Lebanon, NH Protein structure/function consultation.

Society and Organization Memberships:

American Society of Cell Biology Biophysical Society, Membership Committee member (2007 – 2010) Sigma Xi, Dartmouth College Chapter

Peer Review for Journals:

2012 – 2017, Editorial board member for the Journal of Biological Chemistry

Ad hoc review for: Nature, Nature Structural and Molecular Biology, Nature Communications, Nature Scientific Reports, Science, Cell, Structure, BMC Genomics, European Journal of Biochemistry, Biophysical

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Journal, Journal of Theoretical Biology, Journal of Biological Chemistry, Journal of Cell Biology, PNAS, Biochemistry

Grant Review:

NIH – BACP study section, standing member, 6 year term started June 2013 NIH - F13 Infectious Diseases and Microbiology Fellowship Review Panel – 03/13 Petroleum Research Fund (ad hoc) Qatar National Research Fund (ad hoc) American Heart Association – NEA6 Peer Review Study Section (4 year term) Spring 2006 – 2010. NIH – Macromolecular Structure Function C (MSFC) study section – 02/09 – ad hoc NIH – F04B Study section – 07/09, 03/10, 07/10 – ad hoc

Dartmouth College Committees and Service:

Department of Chemistry committees: Undergraduate Advisory Committee (Fall 2003 – present; Chair – 2005, 2012, 2016) Graduate Student Enrollment Committee (Spring 2002 – Spring 2003) Biophysical Faculty Search Committees (2003, 2005)

Service to the MCB graduate program: Co-organizer, 2002 MCB Annual retreat Organizer, 2003 MCB Annual retreat

Dartmouth College committees (standing) and service: Parlimentarian for A&S faculty meetings (2016 – present) First Year Student Enrichment Program, faculty advisory committee and mentor (2010 – present) Ski Team Faculty Advisor (2009 – present) Dartmouth Radiation Safety Committee (member 2008 – present, Chair 2010 – present) Dartmouth College Grant Management Committee (2005 – present) Dartmouth College Grant Advisory Board (2004 – present) Dartmouth Alumni Magazine, Editorial Board Member, 2014 – 2017 Organizer, DCAL Teaching Science Seminar (2009 – 2014) DCAL Faculty Advisory Committee (2010 – 2015) Council on Sponsored Activites (2010-2012) A&S Committee on the Faculty (2009 – 2012) Dartmouth Medical School MD/PhD admission committee member (Chemistry representive, 2006 – 2010) Dartmouth Outing Club Advisory Council (2003 – 2010) Faculty Representative to the Dartmouth Alumni Council (2006 – 2008) Committee on Student Life (2002 – 2005)

Dartmouth College committees and working groups (ad-hoc): Search Committee Co-chair, Director of the Arthur Irving Institute for Energy and Society (2016 – present) Academic at Risk and Re-Entry Students Working Group, Dean of the College Office (2011 – 2012) Faculty Strategic Planning Advisory Committee member, Provost’s Office (2010 – 2012) Working Group Member – Pedagogy, Teaching, and Mentoring (2011 – 2012) Working Group Member – Students of the Future (2011 – 2012) Working Group Member – Experimental Dartmouth (2011 – 2012) Working Group Member – Alumni for Life (2011 – 2012) Pilot Committee on Undergraduate Research Member (2010 – 2012) Search Committee member, Dean of the Faculty, President’s Office (2010) HHMI Undergraduate Biological Sciences Education Program Application Organizing Committee (2004, 2009) Search Committee Chair, Director of Outdoor Programs, Dean of the College Office (2008 – 2009) First Year Summer Research Program, Selection Committee Member (2003 – 2007) Search Committee Member, Assistant Director of Outdoor Programs, Dean of the College Office (2006, 2010)

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Search Committee Member, Research Grants Administrator, Dean of the Faculty Office (2006, 2007) Search Committee Member, Director of Outdoor Programs, Dean of the College Office (2004) Dartmouth Outing Club Review Group (2004)

Invited Seminars, Platforms, 1996 – 2017:

February 1996 Biophysical Society Fortieth Annual Meeting March 2000 Baltimore, Maryland EMBL Millennium Symposium in Structural Biology "Crystal Structure of the Motor Domain of Kinesin Reveals European Molecular Biology Laboratory Structural Homology to the Catalytic Domain of Myosin" Heidelberg, Germany “Common themes of molecular motor proteins and G-proteins” June 1996 Department of Chemistry May 2001 Dartmouth College 15th Darmstadt Molecular Modeling Workshop Hanover, New Hampshire Technical University at Darmstadt "The Crystal Structure of the Motor Domain of Human Kinesin" Darmstadt, Germany “High Resolution Protein Structures: How to get them faster and August 1996 what we can learn from them” International Union of Crystallography XVII Congress and General Assembly June 2001 Seattle, Gordon Conference "Crystal Structure of Kinesin Motor Domain Reveals a Structural Motile and Contractile Systems Similarity to Myosin" New London, New Hampshire “Crystal structure of the GTPase domain of dynamin” October 1996 Japanese Society for Cell Biology Annual Meeting September 2001 Kyoto, Japan Society for General Physiologists 2001 Annual Meeting "The Crystal Structure of The Kinesin Motor and Its Similarities to Woods Hole, Myosin and G Proteins" “Crystal structure of an unconventional class I myosin”

University of Tokyo November 2001 Department of Anatomy and Cell Biology Seminar, Pennsylvania Muscle Institute Tokyo, Japan University of Pennsylvania, Philadelphia, PA "The Structure of the Kinesin Motor Reveals Similarities to Myosin “Crystal structure of an unconventional class I myosin” and G Proteins" January 2002 December 1997 Seminar, Department of Molecular Physiology Schloßman Seminar in Nanostructures in Biology, Chemistry and and Biophysics Physics University of Vermont, Burlington, VT Schloss Elmau, Germany “Crystal structure of an unconventional class I myosin” "Structure and Mechanism of the Molecular Motor Protein, Kinesin" Feburary 2002 December 1997 Seminar, Department of Physics Department of Biophysics St. Michael’s College, Colchester, VT Max-Planck-Institute for Medical Research “Mechanisms of molecular motors” Heidelberg, Germany "Structure and Mechanism of the Molecular Motor Protein, Kinesin" February 2002 Biophysical Society, 46th Annual Meeting September 1998 San Francisco, California Institute Seminar Platform talks: Max-Planck-Institute for Medical Research “Crystal structure of a class I myosin motor domain” Heidelberg, Germany presented by my graduate student, Martin Kollmar “The mechanism of motor protein-based force generation” “Switch 1 opens on strong binding to actin” presented by my collaborator, Prof. Kenneth Holmes June 1999 Minicourse on the Cytoskeleton June 2002 Department of Physiology and Biochemistry Gordon Conference University of Milan Muscle: Contractile Systems Milan, Italy New London, New Hampshire "Motor protein of the kinesin superfamily: structure and “Crystal structure of an unconventional class-I myosin” mechanism" October 2002 January 2000 Seminar, Department of Cell Biology Department of Chemistry Columbia University Dartmouth College , NY Hanover, New Hampshire “Conformational changes in myosins, kinesin, and G-proteins” “Mechanisms of Molecular Motors”

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October 2002 February 2008 Seminar, Department of Chemistry Biophysical Society Annual 2008 Meeting, Long Beach California Simons College, Boston, MA Platform “Mechanisms of molecular motors” “Drosophila Nod Has a Kinesin-Like Structure Yet a Myosin-Like ATPase Cycle” November 2002 Seminar, Symposium on Molecular Motors July 2008 Max-Planck Institute, Berlin, Germany Gordon Conference “Pathways of communication in molecular motors” Presentation by postdoc Jared C. Cochran “The Beginning of Nod’s Unique ATPase Cycle ATP Binding May 2003 through Pi Product Release” Fifth Skirball Symposium, "Molecular Machines" New York University's Skirball Institute of Biomolecular Medicine, February 2009 New York City, NY University of , Orono “Mechanochemical coupling in kinesin and myosin” “Mechanism of molecular motor proteins”

February 2004 February 2009 Biophysical Society 48th Annual Meeting National Synchrotron Light Source, Brookhaven, NY Baltimore, MD “The missing link between motor proteins and transcription factors” Invited Symposium Speaker October 2009 July 2004 US-Japan Conference on Cholera and Other Bacterial Enteric Woods Hole - Marine Biological Laboratory Infections Cytoskleteon and Cell Motility Seminar “Crystal structure of the Vibrio cholerae virulence factor regulator ToxT” October 2004 Boston University, Department of Physiology and Biophysics, December 2011 Departmental Seminar US-Japan Conference on Cholera and Other Bacterial Enteric Infections, “Crystal structure of the Vibrio cholerae virulence factor regulator February 2006 AphB” Biophysical Society Annual Meeting Platform presentation by Rukman DeSilva (graduate student) February 2013 “Structural studies towards understanding the interactions of the Brookhaven National Laboratory, X6A 10th anniversary symposium Vibrio cholerae virulence gene activator AphA with the tcpPH “Structural analysis of bacterial virulence regulators” promoter” March 2013 October 2006 University of Vermont Biophysical Society Discussions “Fine tuning the catalytic cycle of molecular motors” Asilomar, California “Mechanochemical coupling in kinesin family motors” April 2013 LSU School of Medicine & Health Sciences Center April 2007 “Fine tuning the catalytic cycle of molecular motors” Department of Chemistry Holy Cross December 2015 “Mechanochemical coupling in kinesin family motors” Middlebury Department of Chemistry “Using fatty acids to prevent cholera and other enteric diseases”

Publications: (in reverse chronological order)

42. Privett BR, Pellegrini M, Kovacikova G, Taylor RK, Skorupski K, Mierke D, Kull FJ. (2017) Identification of a Small Molecule Activator for AphB, a LysR-Type Virulence Transcriptional Regulator in Vibrio cholerae. In preparation for Biochemistry. 41. Midgett CR, Almagro-Moreno S, Pellegrini M, Taylor RK, Skorupski S, and Kull FJ. (2017) Bile salts and alkaline pH reciprocally modulate the interaction between the periplasmic domains of Vibrio cholerae ToxR and ToxS. Molecular Microbiology, Under review. 40. Woodbrey AK, Onyango EO, Pellegrini M, Kovacikova G, Taylor RK, Gribble GW, Kull FJ. (2017) A new class of inhibitors of the AraC family virulence regulator Vibrio cholerae ToxT. Nature Scientific Reports, in press.

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39. Shi W, Kovacikova G, Lin W, Taylor RK, Skorupski K, and Kull FJ. (2015) The 40-residue insertion in Vibrio cholerae FadR facilitates binding of an additional fatty acyl-CoA ligand. Nature Communications. 2015 Jan 21;6:6032. PMID: 25607896. PMCID: PMC4336772. 38. Kull FJ, Sloboda RD. (2014) A slow dance for microtubule acetylation. Cell. 2014 Jun 5;157(6):1255-6. doi: 10.1016/j.cell.2014.05.021. PMID: 24906144 37. Cochran JC, Thompson ME, Kull FJ. (2013) Metal Switch Controlled Myosin II from Dictyostelium discoideum Supports Closure of Nucleotide Pocket During ATP Binding is Coupled to Myosin Detachment from Actin Filaments. J Biol Chem. Sep 27;288(39):28312-23. PMID: 23960071. PMCID: PMC3784747. 36. Cochran JC, Kull FJ. (2013) “A molecular motor finds its track.” Nat Struct Mol Biol. Aug;20(8):920-1. PMID: 23912357 35. Kull FJ, Endow SA. (2013) “Force generation by kinesin and myosin cytoskeletal motor proteins.” J Cell Sci. Jan 1;126(Pt 1):9-19. doi: 10.1242/jcs.103911. Epub 2013 Mar 13. PMID: 23487037 34. Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ. (2013) “FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation.” Nat Struct Mol Biol. Jan;20(1):111-8. doi: 10.1038/nsmb.2462. Epub 2012 Dec 9. PMID: 23222643 33. Taylor JL, White SR, Lauring B, Kull FJ. (2012) “Crystal structure of the human spastin AAA domain.” Journal of Structural Biology. Aug;179(2):133-7. Epub 2012 Mar 14. PMID: 22446388. PMCID: PMC3411929 32. Taylor, J. L., R. S. De Silva, G. Kovacikova, W. Lin, R. K. Taylor, K. Skorupski and F. J. Kull (2011) “The crystal structure of AphB, a virulence gene activator from Vibrio cholerae, reveals residues that influence its response to oxygen and pH.” Molecular Microbiology. Feb;83(3):457-70. PMID:22053934. PMCID: PMC3262181. Note: Featured in a “MicroCommentary” in Molecular Microbiology. 31. Cochran, J. C., Y. C. Zhao, D. E. Wilcox, and F. J. Kull (2011) “A metal switch for controlling the activity of molecular motor proteins.” Nature Structural and Molecular Biology. Dec 25;19(1):122-7. PMID:22198464. PMCID: PMC3252401. 30. Waitzman, J. S., A. G. Larson, J. C. Cochran, N. Naber, R. Cooke, F. J. Kull, E. Pate and S. E. Rice (2011) “The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5.” Biophysical Journal, Dec 7;101(11):2760-9. doi: 10.1016/j.bpj.2011.10.032. PMID: 22261065. PMCID: PMC3297777 29. Endow, S. A., F. J. Kull and H. Liu (2010) "Kinesins at a glance." J Cell Sci. 123(Pt 20): 3420-3424. PMID: 20930137 PMCID: PMC2951464 28. Heuston, E., C. E. Bronner, F. J. Kull and S. A. Endow (2010) "A kinesin motor in a force-producing conformation." BMC Struct Biol. 10: 19. PMID: 20602775 PMCID: PMC2906495 Note: Commentary in BMC Biology. 27. Lowden, M. J., K. Skorupski, M. Pellegrini, M. G. Chiorazzo, R. K. Taylor and F. J. Kull (2010) "Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes." Proc Natl Acad Sci USA. 107(7): 2860-2865. PMID: 20133655. PMCID: PMC2840316 Note: Selected as an Editors’ Choice in Science magazine. 26. Zhao, Y. C., F. J. Kull and J. C. Cochran (2010) "Modulation of the kinesin ATPase cycle by neck linker docking and microtubule binding." J Biol Chem. 285(33): 25213-25220. PMID: 20558732. PMCID: PMC2919084 25. Cochran, J. C., C. V. Sindelar, N. K. Mulko, K. A. Collins, S. E. Kong, R. S. Hawley and F. J. Kull (2009) "ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement." Cell. 136(1): 110-122.

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24. Cochran, J. C. and F. J. Kull (2008) "Kinesin motors: no strain, no gain." Cell. 134(6): 918-919. 23. De Silva, R. S., G. Kovacikova, W. Lin, R. K. Taylor, K. Skorupski and F. J. Kull (2007) "Crystal structure of the Vibrio cholerae quorum-sensing regulatory protein HapR." J Bacteriol. 189(15): 5683-5691. 22. Durrwang, U., S. Fujita-Becker, M. Erent, F. J. Kull, G. Tsiavaliaris, M. A. Geeves and D. J. Manstein (2006) "Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis." J Cell Sci. 119(Pt 3): 550-558. 21. Goetz, J. A., S. Singh, L. M. Suber, F. J. Kull and D. J. Robbins (2006) "A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form." J Biol Chem. 281(7): 4087-4093. 20. De Silva, R. S., G. Kovacikova, W. Lin, R. K. Taylor, K. Skorupski and F. J. Kull (2005) "Crystal structure of the virulence gene activator AphA from Vibrio cholerae reveals it is a novel member of the winged helix transcription factor superfamily." J Biol Chem. 280(14): 13779-13783. 19. Reubold, T. F., S. Eschenburg, A. Becker, M. Leonard, S. L. Schmid, R. B. Vallee, F. J. Kull and D. J. Manstein (2005) "Crystal structure of the GTPase domain of rat dynamin 1." Proc Natl Acad Sci U S A. 102(37): 13093-13098. 18. Kull, F. J. and S. A. Endow (2004) "A new structural state of myosin." Trends Biochem Sci. 29(3): 103-106. 17. Holmes, K. C., I. Angert, F. J. Kull, W. Jahn and R. R. Schroder (2003) "Electron cryo-microscopy shows how strong binding of myosin to actin releases nucleotide." Nature. 425(6956): 423-427. 16. Reubold, T. F., S. Eschenburg, A. Becker, F. J. Kull and D. J. Manstein (2003) "A structural model for actin- induced nucleotide release in myosin." Nat Struct Biol. 10(10): 826-830. 15. Kollmar, M., U. Durrwang, W. Kliche, D. J. Manstein and F. J. Kull (2002) "Crystal structure of the motor domain of a class-I myosin." EMBO J. 21(11): 2517-2525. 14. Kull, F. J. and S. A. Endow (2002) "Kinesin: switch I & II and the motor mechanism." J Cell Sci. 115(Pt 1): 15-23. 13. Tsiavaliaris, G., S. Fujita-Becker, R. Batra, D. I. Levitsky, F. J. Kull, M. A. Geeves and D. J. Manstein (2002) "Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium." EMBO Rep. 3(11): 1099-1105. 12. Kliche, W., S. Fujita-Becker, M. Kollmar, D. J. Manstein and F. J. Kull (2001) "Structure of a genetically engineered molecular motor." EMBO J. 20(1-2): 40-46. PMCID: PMC140180. 11. Niemann, H. H., M. L. Knetsch, A. Scherer, D. J. Manstein and F. J. Kull (2001) "Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms." EMBO J. 20(21): 5813-5821. 10. Kull, F. J. (2000) "Motor proteins of the kinesin superfamily: structure and mechanism." Essays Biochem. 35: 61-73. 9. Sack, S., F. J. Kull and E. Mandelkow (1999) "Motor proteins of the kinesin family. Structures, variations, and nucleotide binding sites." Eur J Biochem. 262(1): 1-11. 8. Kull, F. J. and R. J. Fletterick (1998) "Is the tubulin/FtsZ fold related to the G-protein fold?" Trends Cell Biol. 8(8): 306-307. 7. Kull, F. J., R. D. Vale and R. J. Fletterick (1998) "The case for a common ancestor: kinesin and myosin motor proteins and G proteins." J Muscle Res Cell Motil. 19(8): 877-886. 6. Kull, F. J., E. P. Sablin, R. Lau, R. J. Fletterick and R. D. Vale (1996) "Crystal structure of the kinesin motor domain reveals a structural similarity to myosin." Nature. 380(6574): 550-555. 5. Sablin, E. P., F. J. Kull, R. Cooke, R. D. Vale and R. J. Fletterick (1996) "Crystal structure of the motor domain of the kinesin-related motor ncd." Nature. 380(6574): 555-559.

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4. Eden, D., B. Q. Luu, D. J. Zapata, E. P. Sablin and F. J. Kull (1995) "Solution structure of two molecular motor domains: nonclaret disjunctional and kinesin." Biophys J. 68(4 Suppl): 59S-64S; discussion 65S. 3. Fujiwara, S., F. J. Kull, E. P. Sablin, D. B. Stone and R. A. Mendelson (1995) "The shapes of the motor domains of two oppositely directed microtubule motors, ncd and kinesin: a neutron scattering study." Biophys J. 69(4): 1563-1568. PMCID: PMC1236387. 2. Vale, R. D., C. M. Coppin, F. Malik, F. J. Kull and R. A. Milligan (1994) "Tubulin GTP hydrolysis influences the structure, mechanical properties, and kinesin-driven transport of microtubules." J Biol Chem. 269(38): 23769-23775. 1. Kull, F.J., M. F. Reed, T. E. Elgren, T. L. Ciardelli and D. E. Wilcox (1990) Solid-Phase Peptide Synthesis of the alpha- and beta Domains of Human Liver Metallothionein 2 and the Metallothionein of Neurospora crassa. Journal of the American Chemical Society. 112:2291-2298.

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