OMB No 1545-0052 OReturn of Private Foundatio n F(%rm 990-PF or Section 4947(a)(1) Nonexempt Charitable Trust 201 2 Departrnant of the Treasury Treated as a Private Foundation Internal Revenue Service Note. The foundation may be able to use a co py of this return to satisfy state re portin g re q uirements en o u ,c Ins ,on For calendar year 2012 or tax year beginning , and ending Name of foundation A Employer identification number THE LAWRENCE ELLISON FOUNDATION FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Number and street (or P O box number if mail is not delivered to street address) Room/swte B Telephone number C/O 101 YGNACIO VALLEY ROAD 310 ( 925 ) 977-9060 City or town, state, and ZIP code C If exemption application i5 pending, check here ► WALNUT CREEK, CA 94596 G Check all that apply 0 Initial return initial return of a former public charity D 1. Foreign organizations, check here Q Final return Amended return 2. Foreign organizations meeting the 85% test. Address chan g e OX Name chan g e check here and attach computation H Check type of organization O Section 501(c)(3) exempt private foundation E If private foundation status was terminated 0 Section 4947 (a )( 1 ) nonexempt charitable trust 0 Other taxable p rivate foundation under section 507(b)(1)(A), check here ► 0 I Fair market value of all assets at end of year J Accounting method 0 Cash Accrual F If the foundation is in a 60-month termination (from Part ll, col. (c), line 16) 0 Other (specify) under section 507(b)(1)(B), check here ► $ 17 , 2 2 2 , 17 7 . (Part 1, column (d) must be on cash basis) part I Analysis of Revenue and Expenses ( a) Revenue and (b) Net investment (c) Adjusted net ( d) Disbursements (The total of amounts in columns (b), (c), and (d) may not for charitable u books necessarily equal the amounts in column (a)) exp enses per income income (cash basisP only)ySes 1 Contributions, gifts, grants, etc , received 45,632,000 .

2 Check ► = if the foundation is not required to attach Sch B 3 Interest ^nts and temporary Vonn 39 ,817. 39,817. 39, 817. PA.PE Jr 1 4 Dividends and interest from securities 96,000. 96,000. 96, 0 0 0. TATEMENT 2 5a Gross rents

b Net rental income or (loss)

6a Net gain or ( loss) from sale o e 34,237. : .l i'#-1.T+7'A L.'4.3. 3 Gross sales b assets on in 6a 0- ma 0 7 Capital gain n t income m 45,666,959. :: M 8 Net short-te • c ital gain 0 . 9 Income mod ons NQV Gross sales les f to $ 10a and allowances b Less Cost of g ds solO c Gross profit o (loss) _ . _ 11 Other income 12 Total Add lines 1 throug h 11 45 802 054. 45 802 776. 135 , 817. 13 Compensation of officers, directors , trustees , etc 0 . 0 . 0 . 0 . 14 Other employee salaries and wages .. 632,889 . 0. 0. 537,956 . 15 Pension plans, employee benefits 45,867 . 0. 0. 38,987 . 16a Legal fees STMT 4 19,892. 0. 0. 10 , 696 . STMT 5 71,630. CL b Accounting fees 0. 0. 64,467. W c Other professional fees STMT 6. 186,519. 0.- 0. 182,766. 17 Interest _ 2 18 Taxes STMT 7 951, 225. 0. 0. 945,791. 2 19 Depreciation and depletion 2,919. 0 . 0. 20 Occupancy 130, 096. 0. 0. 110,582. a 21 Travel, conferences, and meetings 69,536. 0 . 0. W9, 5 3 6. C 22 Punting and publications 23 Other expenses STMT .8 _ 373 , 686. 0. 0. 364 , 470. o 24 Total operating and administrative a expenses . Add lines 13 through 23 2,484,259. 0. 0. 2, 325,251. 0 25 Contributions, gifts, grants paid _ 46 , 418 , 840. -46- f 4-l-8 , 840. 26 Total expenses and disbursements. Add lines 24 and 25 48, 903 099. 0. 0. 48 744 091. 27 Subtract line 26 from line 12

a Excess of revenue over expenses and disbursements <3, 101,045. > b Net investment income (if negative, enter -0-) 45,802,776 e Ad lusted net income (if negative, enter -0- 135 , 817. 223501 12-05-12 LHA For Paperwork Reduction Act Notice, see instructions . (1Q Z Form 990-PF (2012) 1 u 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 98 27 1__ THE LAWRE• ELLISON FOUNDATION I Fnrmgqn - PFr9n191 IFKA THE ET.TLTSON MEDTCAT, FO1JNJ)ATTC)N1 94-1269877 D-Ij Beginning of year End of year P^ ^[ Balance Sheets columnAt°^idshoulddi1^abeforend-o1ndamountinthedes-ynramounts mpton only (a) Book Value (b) Book Value (c) Fair Market Value 1 Cash - non -interest-bearing .... 2 Savings and temporary cash investments 20,316,123. 17,192,018. 17,192,018. 3 Accounts receivable ► allowance for Less . doubtful accounts ► 4 Pledges receivable ► for Less allowance doubtful accounts ► 5 Grants receivable ... .. - - 6 Receivables due from officers , directors, trustees , and other disqualified persons 7 Other notes and loans moenatite allowance Less * for doubtful accounts ► 8 Inventories for sale or use 9 Prepaid expenses and deferred charges - . - - < 10a Investments - U S and state government obligations b Investments - corporate stock . - c Investments - corporate bonds - - Investments 11 - land, buildings, and equipment basis - •• ►

Less accumulated depn abon ► 12 Investments - mortgage loans . - 13 Investments - other 14 4 2 , 5 7 3 Land, buildings, and equipment . basis ► Less aavmuwud depa+auon STMT 35, 282:_ 7,350. 7,291. 7,291. 15 Other assets (describe ► STATEMENT 10 ) 25,504. 48,372. 22,868.

16 Total assets (to be com pleted by all filers ) 2 0 , 348 , 977. 17 , 247 , 681. 17 , 222 , 177. 17 Accounts payable and accrued expenses 18 Grants payable - m 19 Deferred revenue

20 Loans from officers, directors , trustees , and other disqualified persons .Lu 21 Mortgages and other notes payable - . . STATEMENT 11 ) J 22 Other liabilities (describe ► 3 , 468. 3 , 217.

23 Total liabilities (add lines 17 throu g h 22) 3 , 468. 3 , 217. Foundations that follow SFAS 117, check here ► and complete lines 24 through 26 and lines 30 and 31. N 24 Unrestricted 25 Temporarily restricted To m 26 Permanently restricted C Foundations that do not follow SFAS 117 , check here - ► FXC LL and complete lines 27 through 31. ° 27 Capital stock, trust principal, or current funds 0. 0. 28 Paid-in or capital surplus , or land , bldg , and equipment fund 37,726,853. 37,726,853. 29 Retained earnings , accumulated income , endowment, or other funds - <17,381,344. > <20,482,389. > Z 30 Total net assets or fund balances 20,345,509. 17,244,464.

31 Total liabilities and net assets and balances 20 , 348 , 977. 17 , 247 , 6 81. part Uk Analysis of Changes in Net Assets or Fund Balances

1 Total net assets or fund balances at beginning of year - Part II, column (a), line 30 (must agree with end-of-year figure reported on prior year's return) - - 1 20,345,509. 2 Enter amount from Part I, line 27a 2 <3,101,045.> 3 Other increases not included in line 2 (itemize) ► 3 0. 4 Add lines 1, 2, and 3 ...... 5 Decreases not included in line 2 (itemize) ► 0. 6 Total net assets or fund balances at end of year (line 4 minus line 51- Part II_ column 17,244,464. Form 990-PF (2012) 223511 12-05-12 2 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 982 -7 1 ___ - THE LAWRE• ELLISON FOUNDATION • Fgrm990-PF(2012) ( FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Page 3 Part tV Capital Gains and Losses for Tax on Investment Income (a) List and describe the kind (s) of property sold (e g , real estate, (b How acquired (c) Date acquired (d) Date sold Purchase (mo 2-storyry brick warehouse , or common stock, 200 shs MLC Co ) D Donation ,day, yr) (mo , day, yr.) 1a 1,600,000 SHS ORACLE CORP. COMMON STOCK D 10/27/77 04/12/12 b c d e (e) Gross sales puce (f) Depreciation allowed ( g) Cost or other basis ( h) Gain or (loss) (or allowable ) plus expense of sale (e) plus (f) minus (g) a 45,666,971. 12. 45,666,959. b c d e Complete only for assets showing gain in column (h) and owned by the foundation on 12/31/69 (I) Gains (Col (h) gain minus Adjusted basis k) Excess of col (i) col. but not less than -0-) or (j) ( (Loss (i) F M V as of 12/31/69 as of 12/31/69 over col (j), if any s (from a 45,666,959. b c d e If gain, also enter in Part I, line 7 2 Capital gain net income or (net capital loss ) If (loss), enter -0- in Part I , line 7 . . . 2 45,666,959. 3 Net short-term capital gain or (loss ) as defined in sections 1222(5) and (6) If gain, also enter in Part I , line 8, column (c) If loss enter-0- in Part I line 8 3 0. Part Qualification Under Section 4940(e) for Reduced Tax on Net Investment Income (For optional use by domestic private foundations subject to the section 4940(a) tax on net investment income )

If section 4940(d)(2) applies, leave this part blank

Was the foundation liable for the section 4942 tax on the distributable amount of any year in the base period? Yes 0 No If'Yes ' the foundation does not qualify under section 4940 (e) Do not complete this part 1 Enter the appropriate amount in each column for each year, see the instructions before making any entries (b) Base priiode years Distributionn ratio Calendar ear or tax year beg innin g Adjusted qualifying distributions Net value of nonchantable)assets-use (col (b) divided by col (c)) 2011 46,316,571. 47,728,130. .970425 2010 40,745,690. 34,401,174. 1.184427 2009 42,733,700. 19,374,570. 2.205659 2008 33,279,981. 38,851,550. .856593 2007 35 281 930. 26 158 579. 1.348771

2 Total of line 1, column (d) 2 6.565875 3 Average distribution ratio for the 5-year base period - divide the total on line 2 by 5, or by the number of years the foundation has been in existence if less than 5 years . . 3 1. 313175

4 Enter the net value of nonchardabte -use assets for 2012 from Part X , line 5 4 36, 530,520.

5 Multiply line 4 by line 3 5 47,970,966.

6 Enter 1 % of net investment income ( 1 % of Part I , line 27b) 6 458 , 028.

7 Addlines5and6 7 48,428,994.

8 Enter qualifying distributions from Part XII, line 4 8 4 8, 747,230. If line 8 is equal to or greater than line 7, check the box in Part VI, line 1 b, and complete that part using a 1 % tax rate See the Part VI instructions 223521 12-05-12 Form 990-PF (2012)

14251031 731920 9827 2012.04030 THE LAWRENC E ELLISON FOUNDA_982__7___L _ _ - THE LAWRE• ELLISON FOUNDATION • Form 990-PF 2012 ( FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Page 4 Part ill Excise Tax Based on Investment Income (Section 4940(a), 4940(b), 4940(e), or 4948 - see instructions) 1a Exempt operating foundations described in section 4940(d)(2), check here ► 0 and enter'N/A' on line 1. Date of ruling or determination letter (attach copy of letter if necessary-see instructions) b Domestic foundations that meet the section 4940(e) requirements in Part V, check here ► OX and enter 1% 1 458,028. of Part I, line 27b ...... c All other domestic foundations enter 2% of line 27b Exempt foreign organizations enter 4% of Part I, line 12, col (b). 2 Tax under section 511 (domestic section 4947(a)(1) trusts and taxable foundations only Others enter -0-) 2 0. 3 Add lines 1 and 2 3 458,028. 4 Subtitle A (income) tax (domestic section 4947(a)(1) trusts and taxable foundations only. Others enter -0-) 4 0. 5 Tax based on investment income . Subtract line 4 from line 3 If zero or less, enter -0- 5 458,028. 6 Credits/Payments a 2012 estimated tax payments and 2011 overpayment credited to 2012 6a 919 ,933 . b Exempt foreign organizations - tax withheld at source 6b c Tax paid with application for extension of time to file (Form 8868) . 6c d Backup withholding erroneously withheld . _ _ . . . 6d 7 Total credits and payments Add lines 6a through 6d . . 7 919,933. 8 Enter any penalty for underpayment of estimated tax Check here rf Form 2220 is attached 8 9 Tax due. If the total of lines 5 and 8 is more than line 7, enter amount owed ._ _ ► 9 461,905. 10 Overpayment . If line 7 is more than the total of lines 5 and 8, enter the amount overpaid ► 10 4 61 9 0 5 0. 11 Enter the amount of line 10 to be Credited to 2013 estimated tax ► . 1 Refunded ► 11 Part VII-A Statements Regarding Activities 1 a Dunng the tax year, did the foundation attempt to influence any national, state, or local legislation or did it participate or intervene in Yes No any political campaign2 . . 1a X b Did it spend more than $100 during the year (either directly or indirectly) for political purposes (see instructions for definition)' _ lb X If the answer is "Yes" to laor 1b, attach a detailed description of the activities and copies of any matenals published or distributed by the foundation in connection with the activities. c Did the foundation file Form 1120 -POL for this year? 1c X d Enter the amount (if any) of tax on political expenditures (section 4955) imposed dunng the year 0. 0. (1) On the foundation ► $ (2) On foundation managers ► $ e Enter the reimbursement (if any) paid by the foundation during the year for political expenditure tax imposed on foundation managers ► $ 0 2 Has the foundation engaged in any activities that have not previously been reported to the IRS? 2 X If "Yes," attach a detailed description of the activities. 3 Has the foundation made any changes, not previously reported to the IRS, in its governing instrument, articles of incorporation, or bylaws, or other similar instruments? If "Yes," attach a conformed copy of the changes .. 3 X 4a Did the foundation have unrelated business gross income of $1,000 or more during the year? .. 4a X b If 'Yes," has it filed a tax return on Form 990-T for this year? . N/A 4b 5 Was there a liquidation, termination, dissolution, or substantial contraction during the year? 5 X If "Yes," attach the statement required by General Instruction T. 6 Are the requirements of section 508(e) (relating to sections 4941 through 4945) satisfied either • By language in the governing instrument, or • By state legislation that effectively amends the governing instrument so that no mandatory directions that conflict with the state law remain in the governing instrument? . . . 6 X 7 Did the foundation have at least $5,000 in assets at any time dunng the year? 7 X If "Yes," complete Part ll, col. (c), and Part XV. 8a Enter the states to which the foundation reports or with which it is registered (see instructions) ► CA, MD, NY b If the answer is'Yes* to line 7, has the foundation furnished a copy of Form 990-PF to the Attorney General (or designate) of each state as required by General Instruction G? If "No," attach explanation 8b X 9 Is the foundation claiming status as a private operating foundation within the meaning of section 4942(1)(3) or 4942(1)(5) for calendar year 2012 or the taxable year beginning in 2012 (see instructions for Part XIV)' If "Yes," complete Part XIV...... 9 X 10 Did any persons become substantial contributors dunng the tax year? If 'Yes,' attach a schedule iisenq their names and addresses 10 X Form 990-PF (2012)

223531 12-05-12 4 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 THE LAWRE0 ELLISON FOUNDATION orm990-PF 2012 ( FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Page 5 Part VH-A Statements Regarding Activities (continued) 11 At any time during the year, did the foundation , directly or indirectly, own a controlled entity within the meaning of • section 512 (b)(13)') If 'Yes," attach schedule (see instructions) ...... 11 X 12 Did the foundation make a distribution to a donor advised fund over which the foundation or a disqualified person had advisory privileges? If 'Yes, attach statement (see instructions) 12 X 13 Did the foundation comply with the public inspection requirements for its annual returns and exemption application? _ 13 X WWW. ELL I SONFOUNDAT I ON . ORG Website address ► 14 Thebooksareincareof ► PHILIP B. SIMON Telephone no ► (925) 977-9060 WALNUT CREEK, CA 94596 t_ocatedat ► C/O 101 YGNACIO VALLEY RD #320, ZIP+4 ► 15 Section 4947 (a)(1) nonexempt charitable trusts filing Form 990-PF in lieu of Form 1041 - Check here . . ... _ ► and enter the amount of tax-exempt interest received or accrued during the year ► 15 N/A 16 At any time during calendar year 2012, did the foundation have an interest in or a signature or other authority over a bank, Yes No securities , or other financial account in a foreign country? 16 X See the instructions for exceptions and filing requirements for Form TD F 90-22 1 If 'Yes, enter the name of the foreign count ► Part VII-B Statements Regarding Activities for Which Form 4720 May Be Required File Form 4720 if any item is checked in the "Yes" column , unless an exception applies. Yes No 1 a During the year did the foundation (either directly or indirectly) (1) Engage in the sale or exchange , or leasing of property with a disqualified person? 0 Yes EXI No (2) Borrow money from, lend money to, or otherwise extend credit to (or accept it from) a disqualified persons 0 Yes EXI No (3) Furnish goods , services , or facilities to ( or accept them from) a disqualified person? . . LI Yes No (4) Pay compensation to, or pay or reimburse the expenses of, a disqualified persons , O Yes LI No (5) Transfer any income or assets to a disqualified person (or make any of either available for the benefit or use of a disqualified person )? LI Yes 0 No (6) Agree to pay money or property to a government official? (Exception. Check 'No* if the foundation agreed to make a grant to or to employ the official for a penod after termination of government service , if terminating within 90 days ) _ . _. 0 Yes FX No b If any answer is'Yes'to l a(l)-(6), did any of the acts fail to qualify under the exceptions described in Regulations section 53 4941 (d)-3 or in a current notice regarding disaster assistance (see instructions)? 1b X Organizations relying on a current notice regarding disaster assistance check here ► LI c Did the foundation engage in a prior year in any of the acts described in la, other than excepted acts , that were not corrected before the first day of the tax year beginning in 2012? 1 c X 2 Taxes on failure to distribute income (section 4942 ) (does not apply for years the foundation was a private operating foundation defined in section 4942 (j)(3) or 4942 (j)(5)) a At the end of tax year 2012, did the foundation have any undistributed income (lines 6d and 6e, Part XIII ) for tax year(s) beginning before 2012? - - = Yes [XI No If "Yes; list the years ► b Are there any years listed in 2a for which the foundation is not applying the provisions of section 4942(a)(2) (relating to incorrect valuation of assets ) to the year's undistributed income? ( If applying section 4942(a)(2) to all years listed, answer 'No' and attach statement - see instructions ) . .. . N/A c If the provisions of section 4942(a)(2) are being applied to any of the years listed in 2a, list the years here

3a Did the foundation hold more than a 2% direct or indirect interest in any business enterprise at any time during the year? _ . _ _ _ _ . _ _ 0 Yes EX-1 No b If'Yes' did it have excess business holdings in 2012 as a result of (1) any purchase by the foundation or disqualified persons after May 26, 1969, (2) the lapse of the 5-year period (or longer period approved by the Commissioner under section 4943(c)(7)) to dispose of holdings acquired by gift or bequest , or (3) the lapse of the 10-, 15-, or 20-year first phase holding penod') (Use Schedule C, Form 4720, to determine if the foundation had excess business holdings in 2012) . N/A 3b 4a Did the foundation invest during the year any amount in a manner that would jeopardize its charitable purposes? X b Did the foundation make any investment in a prior year (but after December 31, 1969) that could jeopardize its charitable purpose that had not been removed from ieooardv before the first day of the tax year beqinninq in 2012? 4b X Form 990-PF (2012)

223541 12-05-12 5 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 THE LAWRIQE ELLISON FOUNDATION Form 990-PF (2012) (FKA THE LISON MEDICAL FOUNDATION) 94-3269827

5a During the year did the foundation pay or incur any amount to: (1) Carry on propaganda, or otherwise attempt to influence legislation (section 4945(e))? _ E] Yes ® No (2) Influence the outcome of any specific public election (see section 4955); or to carry on, directly or indirectly, any voter registration drive? _ Yes ® No (3) Provide a grant to an individual for travel, study, or other similar purposes? ® Yes [J No (4) Provide a grant to an organization other than a chartable, etc., organization described in section 509(a)(1), (2), or (3), or section 4940(d)(2)? . _ . _ . . . _ ® Yes 0 No (5) Provide for any purpose other than religious, charitable, scientific, literary, or educational purposes, or for the prevention of cruelty to children or animals . = Yes ® No b If any answer is'Yes'to 5a(1)-(5), did any of the transactions fail to qualify under the exceptions described in Regulations section 53.4945 or in a current notice regarding disaster assistance (see instructions)? _ 5b X Organizations relying on a current notice regarding disaster assistance check here _ ► Q c If the answer is Yes' to question 5a(4), does the foundation claim exemption from the tax because it maintained expenditure responsibility for the grant? . S,EB STATEMENT 12 ® Yes 0 No If 'Yes, ° attach the statement required by Regulations section 53.4945-5(d). 6a Did the foundation, during the year, receive any funds, directly or indirectly, to pay premiums on a personal benefit contract? Yes © No b Did the foundation, during the year, pay premiums, directly or indirectly, on a personal benefit contract? 6b X If 'Yes' to 6b, file Form 8870. 7a At any time during the tax year, was the foundation a party to a prohibited tax shelter transaction? Yes © No b If 'Yes,' did the foundation receive any proceeds or have any net income attributable to the transaction? N/A 7b Information About Officers, Directors, Trustees, Foundation Managers, Highly 0Part VIII Paid Employees, and Contractors 1 List all officers , directors , trustees, foundation managers and their compensation. ^ Title, and average (c) Compensation Contribut onsto go) Expense em oyeebeneitplans (a) Name and address hdurs perweek devoted ( If not paid, aunt, other position allowances () to enter -0-) compe nsation LAWRENCE J. ELLISON EO PRESIDEN DIRECTO C / O 1 0 1 YGNACIO VALLEY RD. # 320 WALNUT CREEK, CA 9 4 59 6 0.50 0. 0. 0. ANDREW L. DUDNICK S ECRETARY C 7-0 -3-5-1 CALIFORNIA STREET, #1 500 SAN FRANCISCO, CA 9 41 0 4 0.50 0. 0. 0. PHILIP B . SIMON CH IEF FINANCI L OFFICE R C / O 1 0 1 YGNACIO VALLEY RD. 320 WALNUT CREEK , CA 9 4 59 6 1.00 0. 0. 0.

2 Compensation of five highest-paid employees (other than those included on line 1). If none, enter "NONE" (b) Title, and average Contnbuhonsto e1 Expense (a) Name and address of each employee paid more than $50,000 hours per week (c) Compensation defenedPians account, other em^anee ensation devoted to position comp allowances KEVIN J. LEE - 1 0 4 E. RIDGEVILLE EXECUTIVE DI R ECTOR BLVD., MOUNT AIRY, MD 2 1 77 1 -52 6 0 40 . 00 230,920. 12 , 753. 0. RICHARD L. SPROTT - 1 0 4 E . EXECUTIVE DI CTOR RIDGEVILLE BLVD ., MOUNT AIRY , MD 40.00 202,271. 15,478. 0. LISA A . GLAZIER - 1 0 4 E. RIDGEVILLE OFFICE ADMINI S TRATOR BLVD ., MOUNT AIRY , MD 21771 - 52 6 0 40.00 89,755. 9,961. 0. ESTHER PAUL - 1 0 4 E. RIDGEVILLE RANT PROGRAM MANAGER BLVD ., MOUNT AIRY, MD 2 1 77 1 - 52 6 0 40.00 59,500. 3,008. 0.

Total number of other employees paid over $50,000 ► 0 Form 990-PF (2012)

223551 12-05-12 6 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 THE LAWRE0 ELLISON FOUNDATION • Form 990-PF (2012) (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Pagel P)i Information About Officers, Directors, Trustees , Foundation Managers, Highly Paid Employees, and Contractors (continued) 3 Five highest-paid independent contractors for professional services. If none, enter " NONE." (a) Name and address of each person paid more than $50,000 (b) Type of service (c) Compensation NONE

Total number of others receivin g over $50 ,000 for p rofessional services ► 0 I Part Ix-A i summary OT Direct Uhantabie Activities List the foundation 's four largest direct chartable activities during the tax year Include relevant statistical information such as the number of organizations and other beneficiaries served, conferences convened, research papers produced, etc Expenses 12012 SYMPOSIUM AT WOODS HOLE ( COLLOQUIUM ON BIOLOGY OF AGING : SUPPORTING SCIENTIFIC EXCHANGES BRINGING TOGETHER INVESTIGATORS FROM A VARIETY OF DISCIPLINES RE AGING 287,599. 2

3

4

Fart fA-15 I Summary of Program- Related Investments Describe the two largest program - related investments made by the foundation during the tax year on lines 1 and 2 Amount 1 N/A

2

All other program-related investments . See instructions 3

Total . Add lines 1 throug h 3 0. Form 990-PF (2012)

223561 12-05-12

14251031 731920 9827 2 0 12 . 04 0 30 TH E LAWRENCE ELL ISON FOUNDA_98 2.7 1 THE LAWRE0 ELLISON FOUNDATION 4) Form 990-PF (2012) (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Page8

PBFI Minimum Investment Return (All domestic foundations must complete this part . Foreign foundations, see instructions.)

1, Fair market value of assets not used (or held for use) directly in carrying out charitable, etc , purposes* a Average monthly fair market value of securities 1a 0. b Average of monthly cash balances - - - 1b 37,086.822. c Fair market value of all other assets - . d Total (add lines 1a, b, and c) 11d 1 37,086,822. e Reduction claimed for blockage or other factors reported on lines la and 1c (attach detailed explanation) . - - . - - le 0. 2 Acquisition indebtedness applicable to line 1 assets 2 0. 3 Subtract line 2 from line 1d - 3 37,086,822. 4 Cash deemed held for chartable activities Enter 1 1/2% of line 3 (for greater amount, see instructions) 4 556 302. 5 Net value of noncharitable -use assets . Subtract line 4 from line 3 Enter here and on Part V, line 4 5 36,530,520. 5 1,826,526. XI Distributable Amount (see instructions) (Section 4942 (l)(3) and (I)(5) private operating foundations and certain Part foreign organizations check here ► [X and do not complete this part ) 1 Minimum investment return from Part X, line 6 2a Tax on investment income for 2012 from Part VI, line 5 - 2a b Income tax for 2012 (This does not include the tax from Part VI) - 2b c Add lines 2a and 2b 2c 3 Distributable amount before adjustments Subtract line 2c from line 1 . . 3 4 Recoveries of amounts treated as qualifying distributions 4 5 Add lines 3 and 4 5 6 Deduction from distributable amount (see instructions) - - - . - 6 7 Distributable amount as adjusted Subtract line 6 from line 5 Enter here and on Part XIII , line 1 7 Part X^1 Qualifying Distributions (see instructions)

1 Amounts paid (including administrative expenses) to accomplish charitable, etc , purposes a Expenses, contributions, gifts, etc - total from Part I, column (d), line 26 1 a 48,744,091. b Program-related investments - total from Part IX-B 1 b 0. 2 Amounts paid to acquire assets used (or held for use) directly in carrying out charitable, etc , purposes - 2 3,139. 3 Amounts set aside for specific charitable projects that satisfy the: a Suitability test (prior IRS approval required) 3a b Cash distribution test (attach the required schedule) 3b 4 Qualifying distributions . Add lines la through 3b Enter here and on Part V, line 8, and Part XIII, line 4 - , - - 4 48,747,230. 5 Foundations that qualify under section 4940(e) for the reduced rate of tax on net investment income Enter 1 % of Part I, line 27b 5 458 , 028. 6 Adjusted qualifying distributions . Subtract line 5 from line 4 - 6 48, 289,202. Note. The amount on line 6 will be used in Part V, column (b), in subsequent years when calculating whether the foundation qualifies fo r the section 4940(e) reduction of tax in those years Form 990-PF (2012)

223571 12-05-12 8 14251031 731920 9827 2012.04030 THE LAWRENC E ELLISON FOUNDA _9 82.7 1 • • FQrm 990-PF(2012) Page 9 Undistributed Income (see instructions) N/A (a) (b) (c) (d) Corpus Years prior to 2011 2011 2012 1 Distributable amount for 2012 from Part XI, line 7 2 Undistributed income, if any, as of the end of 2012 a Enter amount for 2011 only _ b Total for prior years-

3 Excess distributions carryover, if any, to 2012 a From 2007 b From 2008 c From 2009 d From 2010 e From 2011 f Total of lines 3a through e 4 Qualifying distributions for 2012 from Part XII, line 4 01 $ a Applied to 2011, but not more than line 2a b Applied to undistributed income of prior years (Election required - see instructions) c Treated as distributions out of corpus (Election required - see instructions) d Applied to 2012 distributable amount e Remaining amount distributed out of corpus 5 Excess distributions carryover applied to 2012 (if an amount appears in column (d), the same amount must be shown in column (a) ) 6 Enter the net total of each column as indicated below:

a Corpus Add lines 3f, 4c, and 4e. Subtract line 5 b Prior years' undistributed income. Subtract line 4b from line 2b _ c Enter the amount of prior years' undistributed income for which a notice of deficiency has been issued, or on which the section 4942(a) tax has been previously assessed d Subtract line 6c from line 6b Taxable amount - see instructions e Undistributed income for 2011 Subtract line 4a from line 2a. Taxable amount - see instr f Undistributed income for 2012 Subtract lines 4d and 5 from line 1 This amount must be distributed in 2013 7 Amounts treated as distributions out of corpus to satisfy requirements imposed by section 170(b)(1)(F) or 4942(g)(3) 8 Excess distributions carryover from 2007 not applied on line 5 or line 7 9 Excess distributions carryover to 2013. Subtract lines 7 and 8 from line 6a . 10 Analysis of line 9 a Excess from 2008 b Excess from 2009 c Excess from 2010 d Excess from 2011 e Excess from 2012 Form 990-PF (2012) 223581 12-05-12 9 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 THE LAWRE0 ELLISON FOUNDATION • Form990-PF 2012 ( FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Page10 PartXlV Private Operating Foundations (see instructions and Part VII-A, question 9) 1 a If the foundation has received a ruling o r determination letter that it is a private operating foundation , and the ruling is effective fo r 2012 , enter the date of the ruling lo. ^ b Check box to indicate whether the found ation is a p rivate o peratin g foundation described in section or 2 a Enter the lesser of the adjusted net Tax year Prior 3 yez income from Part I or the minimum (a) 2012 (b) 2011 (c) 201( (d) 2009 1 (e) Total investment return from Part X for each year listed .. 135, 817. 69,981. 65, 144. 105,926. 376,868. b 85%ofline2a 115, 444. 59,484. 55, 372. 90,037. 320,338. c Qualifying distributions from Part XII, line 4 for each year listed 18,747,230. 16,316,571. 0, 745, 690. 13,465,716. 179 , 275 , 207. d Amounts included in line 2c not used directly for active conduct of exempt activities . 16,522,535. 13,611,174. 39,082, 081. 1, 329, 587. 170 , 545 , 377. e Qualifying distributions made directly for active conduct of exempt activities Subtract line 2d from line 2c 2, 224, 695. 2, 705, 397. 1,663, 609. 2,136,129. 8,729,830. 3 Complete 3a , b, or c for the alternative test relied upon a 'Assets' alternative test - enter (1) Value of all assets . . . 0. (2) Value of assets qualifying under section 4942 (j)(3)(B)(i) 0. b 'Endowment' alternative test - enter 2/3 of minimum investment return shown in Part X, line 6 for each year listed. 1, 217, 684. 1, 590, 938. 1,146, 706. 645,819. 4,601,147. c 'Support' alternative test - enter (1) Total support other than gross investment income ( interest, dividends , rents, payments on securities loans (section 51 2(a)(5 )), or royalties) 0. (2) Support from general public and 5 or more exempt organizations as provided in section 4942 (I)(3)(B)(ni) 0. (3) Largest amount of support from an exempt organization . 0. 0. Part XV Supplementary Information (Complete this part only if the foundation had $5,000 or more in assets at any time during the year-see instructions.) 1 Information Regarding Foundation Managers: a List any managers of the foundation who have contributed more than 2% of the total contributions received by the foundation before the close of any tax year (but only if they have contributed more than $5,000) (See section 507(d)(2) ) LAWRENCE J. ELLISON b List any managers of the foundation who own 10% or more of the stock of a corporation (or an equally large portion of the ownership of a partnership or other entity) of which the foundation has a 10% or greater interest NONE 2 Information Regarding Contribution , Grant , Gift, Loan, Scholarship, etc., Programs: Check here 01 = if the foundation only makes contributions to preselected charitable organizations and does not accept unsolicited requests for funds If the foundation makes gifts , grants , etc (see instructions ) to individuals or organizations under other conditions , complete items 2a, b, c, and d a The name , address , and telephone number or e-mail of the person to whom applications should be addressed SEE STATEMENT C ATTACHED

b The form in which applications should be submitted and information and materials they should include SEE STATEMENT C ATTACHED c Any submission deadlines SEE STATEMENT C ATTACHED d Any restrictions or limitations on awards , such as by geographical areas , charitable fields , kinds of institutions, or other factors* SEE STATEMENT C ATTACHED

223601 12-05-12 Form 990-PF (2012) 10 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 THE LAWRE• ELLISON FOUNDATION is 990-PF (2012) (FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Page11 Information 3 Grants and Contributions Paid During the Year or Approved for Future Pa ent Recipient If recipient is an individual, show any relationship to Foundation Purpose of grant or Amount Name and address (home or business ) any foundation manager status of contribution or substantial contributor recipient a Paid during the year

SEE STATEMENT A 46 418 840.

Total ► 3a 46 418 840. b Approved for future payment

SEE STATEMENT B 61 913 978.

TotaI 3b 1 61 , 913 , 978. Form 990-PF (2012) 223611 12-05-12 11 14251031 731920 9827 20 12.04030 TH E LAWRENC E ELLISON FOUNDA 9827 1 THE LAWRE0 ELLISON FOUNDATION • Form 990-PF(2012) (FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Page12 PilitXVI-A Analysis of Income - Producing Activities

Epter 1 dross amounts unless otherwise indicated . Unrelated business income Exclu^ ded by section 512. 513. or 514 (e) (a ) (d) Related or exempt Business 1 Program service revenue code Amount oodone Amount function income a b c d e f 9 Fees and contracts from government agencies 2 Me mbership dues and assessments 3 IntB rest on savings and temporary cash investments 14 39,817. 4 Dividends and interest from securities 14 96,000. 5 Net rental income or (loss ) from real estate. a Debt-financed property b Not debt-financed property 6 Net rental income or (loss ) from personal pro perty 70th er investment income 8 Gain or (loss) from sales of assets other tha n inventory 18 34,237. 9 Net income or (loss) from special events 10 Gross profit or (loss) from sales of inventory 11 0th er revenue a b c d e 12 Subtotal Add columns (b), (d), and (e) 0. 1 170 , 054. 0. 13 Total . Add line 12, columns (b), (d), and (e) 13 170,054. (See worksheet in line 13 instructions to venfy calculations ParF XV!- Relationship of Activities to the Accomplishment of Exempt Purposes

12-0-12 Form 990-PF (2012) 12 14251031 731920 9827 2012.04030 THE LAWRENCE ELL ISON FOUNDA 9 8 27 1 THE LAWRENO ELLISON FOUNDATION • Foim990-PF 2012 ( FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Page 13 Part.XVI! Information Regarding Transfers To and Transactions and Relationships With Noncharitable Exempt Organizations I Did the organization directly or indirectly engage in any of the following with any other organization described in section 501(c) of Yes No the Code ( other than section 501(c)(3 ) organizations ) or in section 527, relating to political organizations? a Transfers from the reporting foundation to a nonchantable exempt organization of. (1) Cash la (l ) X (2) Other assets 1a 2 X b Other transactions* (1) Sales of assets to a noncharitable exempt organization .. 1 b(l ) X (2) Purchases of assets from a nonchantable exempt organization 1 b(2 ) X (3) Rental of facilities , equipment , or other assets 1 b(3 ) X (4) Reimbursement arrangements 1b(4 ) X (5) Loans or loan guarantees 1 b(5 ) X (6) Performance of services or membership or fundraising solicitations 1 b(6) X c Sharing of facilities , equipment , mailing lists, other assets , or paid employees 1 c X d If the answer to any of the above is 'Yes , complete the following schedule . Column (b) should always show the fair market value of the goods , other assets, or services given by the reporting foundation If the foundation received less than fair market value in any transaction or sharing arrangement , sh ow in column (d) the value of the goods , other assets , or services received

2a Is the foundation directly or indirectly affiliated with , or related to , one or more tax-exempt organizations described in section 501 (c) of the Code (other than section 501(c)(3 )) or in section 5279 0 Yes 0 No h If °Yac ' r.mmnlpte the fnllnwlnn scharlllle (a) Name of organization (b) Type of organization ( c) Descnption of relationship N/A

Under penaltt per)ury , ecl that I have examined this return, including accompanying schedules and statements , and to the best of my knowledge May the IRS discuss this information of which arer has an Sign and belie i e, co mplete Declaration of preparer (other than taxpayer) is based on all re knowled g e Here Signa re of er or trustee Da Pnnt/Type preparer ' s name Preparer's signature

Paid PAMELA BURNS ,fc "kcu'r,_ Preparer HOWSON & SIMON LLP Firm's name ► Use Only Firm's address ► 101 YGNAC IO VLY RD . , WALNUT CREEK, CA 9459

223622 12-05-12

14251031 731920 9827 2012.0403 • 0

Schedule B I Schedule of Contributors OMB No 1545-0047 (Form-990, 990-EZ, or 990 -PF) ► Attach to Form 990 , Form 990- EZ, or Form 990-PF. Department of the Treasury 2012 Internal Revenue Service Name of the organization Employer identification number THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON ME DICAL FOUNDATION ) 94-3269827 Organization type (check one):

Filers of. Section:

Form 990 or 990-EZ = 501 (c)( ) (enter number) organization

0 4947(a)(1) nonexempt charitable trust not treated as a private foundation

0 527 political organization

Form 990-PF 0 501(c)(3) exempt private foundation

0 4947 (a)(1) nonexempt charitable trust treated as a private foundation

501(c)(3) taxable private foundation

Check if your organization is covered by the General Rule or a Special Rule. Note . Only a section 501 (c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule. See Instructions.

General Rule

0 For an organization filing Form 990 , 990-EZ, or 990-PF that received, during the year, $5,000 or more (in money or property) from any one contributor. Complete Parts I and II.

Special Rules

For a section 501 (c)(3) organization filing Form 990 or 990-EZ that met the 33 1 /3% support test of the regulations under sections 509(a)(1) and 170 (b)(1)(A)(vi) and received from any one contributor, during the year, a contribution of the greater of (1) $5,000 or (2) 2% of the amount on () Form 990 , Part VIII, line 1 h , or (ii) Form 990-EZ, line 1 . Complete Parts I and II.

For a section 501 (c)(7), (8), or (10) organization filing Form 990 or 990- EZ that received from any one contributor, during the year, total contributions of more than $1,000 for use exclusively for religious , charitable, scientific , literary, or educational purposes, or the prevention of cruelty to children or animals . Complete Parts I, II, and III.

For a section 501 (c)(7), (8), or (10) organization filing Form 990 or 990-EZ that received from any one contributor , during the year, contributions for use exclusively for religious, charitable , etc., purposes, but these contributions did not total to more than $1,000. If this box is checked , enter here the total contributions that were received during the year for an exclusively religious , charitable, etc., purpose. Do not complete any of the parts unless the General Rule applies to this organization because it received nonexclusively religious, charitable, etc., contributions of $5,000 or more during the year _ ► $

Caution . An organization that is not covered by the General Rule and/or the Special Rules does not file Schedule B (Form 990, 990-EZ, or 990-PF), but it must answer 'No" on Part IV, line 2, of its Form 990; or check the box on line H of Its Form 990-EZ or on Part I, line 2 of its Form 990-PF, to certify that it does not meet the filing requirements of Schedule B (Form 990, 990-EZ, or 990-PF).

LHA For Paperwork Reduction Act Notice, see the Instructions for Form 990, 990-EZ, or 990-PF. Schedule B (Form 990, 990-EZ , or 990-PF) (2012)

223451 12-21-12 • • Sehedule B (Form 990, 990•EZ, or 990-PF) (2012) Page 2 Name of organization Employer identification number THE LAWRENCE ELLISON FOUNDATION FFKA THE ELLISON MEDICAL FOUNDATION) 94-3269827

Part J Contributors (see instructions). Use duplicate copies of Part I if additional space is needed.

(a) (b) (c) (CO No. Name, address, and ZIP + 4 Total contributions Type of contribution

1 LAWRENCE J. ELL I SON Person C/O LAWRENCE INVESTMENTS LLC, 101 Payroll YGNACIO VALLEY RD., #320 $ 45,632,000. Noncash 0 (Complete Part II if there WALNUT CREEK, CA 9 4 9 5 6 is a noncash contribution.)

(a) (b) (c) (d) No. Name, address, and ZIP + 4 Total contributions Type of contribution

Person 0 Payroll $ Noncash (Complete Part II if there is a noncash contribution.)

(a) (b) (c) (CO No. Name, address, and ZIP + 4 Total contributions Type of contribution

Person 0 Payroll $ Noncash (Complete Part II if there is a noncash contribution.)

(a) (b) (c) (CO No. Name, address, and ZIP + 4 Total contributions Type of contribution

Person El Payroll Q $ Noncash (Complete Part II if there is a noncash contribution.)

(a) (b) (c) (d) No. Name, address , and ZIP + 4 Total contributions Type of contribution

Person El Payroll Q $ Noncash Q (Complete Part II if there is a noncash contribution.)

(a) (b) (c) (d) No. Name, address, and ZIP + 4 Total contributions Type of contribution

Person 0 Payroll 0 $ Noncash (Complete Part II if there is a noncash contribution.) „ems, 12_21-19 Schedule B (Form 990 . 990-EZ . or 990 -PFI (20121 21 14251031 731920 98 2 7 20 1 2. 04030 THE LAWRENCE ELLISON FOUNDA 9827 1 • 0 Schedule B (Form 990, 990-EZ, or 990-P F 3 Name of organization Employer identification number THE LAWRENCE ELLISON FOUNDATION FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827

Part II Noncash Property (see instructions). Use duplicate copies of Part II if additional space is needed.

(a) (c) No. (b) FMV (or estimate) (d) from Description of noncash property given Date received (see instructions) Part I 1,600,000 SHARES OF ORACLE CORP. 1 COMMON STOCK

$ 45,632,000. 04/10/12

(a) (c) No. (b) FMV (or estimate) (d) from Description of noncash property given Date received (see instructions) Part I

(a) (c) No. (b) FMV (or estimate) (Co from Description of noncash property given Date received (see instructions) Part I

(a) (c) No. (b) FMV (or estimate) (d) from Description of noncash property given Date received (see instructions) Part I

(a) (c) No. (b) FMV (or estimate) (d) from Description of noncash property given Date received (see instructions) Part I

(a) (c) No. (b) FMV (or estimate) (d) from Description of noncash property given Date received (see instructions) Part 1

223453 12-21-12 Schedule B (Form 990 , 990-EZ, or 990 -PF) (2012) 22 14251031 731920 9827 2012. 04 0 30 THE LAWRENCE E LLISON FOUNDA_982.7 1 __ • 0 Schedule B (Form 990, 990-EZ, or 990•PF) (2012) Page 4 Name of organization Employer identification number THE LAWRENCE ELLISON FOUNDATION FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Part ill Exclusive/yreligious , charitable , etc., individual contributions to section 501 (c)(7), (8), or (10) organizations that total more than 1 , 000 for the year . Complete columns (a) through (e) and the following line entry For organizations completing Part Ill, enter the total of exclusively religious, chantable, etc., contributions of $1,000 or less for the year (Enter e o,foR„aton onm) $ Use duplicate copies of Part Ill if additional space is needed. (a) No. from (b) Purpose of gift (c) Use of gift (d) Description of how gift is held Part 1

(e) Transfer of gift

Transferee's name, address, and ZIP + 4 Relationshi p of transferor to transferee

(a) No. from (b) Purpose of gift (c) Use of gift (d) Description of how gift is held Part I

(e) Transfer of gift

Transferee's name , address, and ZIP + 4 Relationshi p of transferor to transferee

(a) No. from (b) Purpose of gift (c) Use of gift (d) Description of how gift is held Part I

(e) Transfer of gift

Transferee's name , address, and ZIP + 4 Relationshi p of transferor to transferee

(a) No. from (b) Purpose of gift (c) Use of gift (d) Description of how gift is held Part I

(e) Transfer of gift

Transferee's name, address, and ZIP + 4 Relationshi p of transferor to transferee

223454 12 -21-12 Schedule B ( Form 990 , 990-EZ , or 990 -PF) (2012) 23 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 THE LAWRENCE ELLISON FcATION (FKA TH • 94-3269827

FORM 990-PF INTEREST ON SAVINGS AND TEMPORARY CASH INVESTMENTS STATEMENT 1

SOURCE AMOUNT

DEUTSCHE BANK 282. VANGUARD PRIME MMF 39,535.

TOTAL TO FORM 990-PF, PART I, LINE 3, COLUMN A 39,817.

FORM 990-PF DIVIDENDS AND INTEREST FROM SECURITIES STATEMENT 2

CAPITAL GAINS COLUMN (A) SOURCE GROSS AMOUNT DIVIDENDS AMOUNT

ORACLE CORPORATION 96,000. 0. 96,000.

TOTAL TO FM 990-PF, PART I, LN 4 96,000. 0. 96,000.

14 STATEMENT(S) 1, 2 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 L THE LAWRENCE ELLISON FO0ATION (FKA TH • 94-3269827

FORM 990-PF GAIN OR (LOSS) FROM SALE OF ASSETS STATEMENT 3

(A) MANNER DATE DESCRIPTION OF PROPERTY ACQUIRED ACQUIRED DATE SOLD

1,600,000 SHS ORACLE CORP. DONATED 10/27/77 04/12/12 COMMON STOCK

(B) (C) (D) (E) (F) GROSS VALUE AT EXPENSE OF SALES PRICE TIME OF ACQ. SALE DEPREC. GAIN OR LOSS

45,666,971. 45,632,000. 0. 0. 34,971.

(A) MANNER DATE DESCRIPTION OF PROPERTY NAME OF BUYER ACQUIRED ACQUIRED DATE SOLD

COMPUTER EQUIP. - DELL N/A PURCHASED 10/21/09 07/01/12 OPTIPLEX 360

(B) (C) (D) (E) (F) GROSS COST OR EXPENSE OF SALES PRICE OTHER BASIS SALE DEPREC. GAIN OR LOSS

0. 754. 0. 415. <339.>

(A) MANNER DATE DESCRIPTION OF PROPERTY NAME OF BUYER ACQUIRED ACQUIRED DATE SOLD

COMPUTER EQUIP. - DELL N/A PURCHASED 01/20/10 07/01/12 OPTIPLEX 360

(B) (C) (D) (E) (F) GROSS COST OR EXPENSE OF SALES PRICE OTHER BASIS SALE DEPREC. GAIN OR LOSS

0. 825. 0. 331. <494.>

15 STATEMENT(S) 3 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 THE LAWRENCE ELLISON Fc DATION (FKA TH • 94-3269827

(A) MANNER DATE DESCRIPTION OF PROPERTY NAME OF BUYER ACQUIRED ACQUIRED DATE SOLD

FURNITURE BOYLAND ELECTRIC, PURCHASED 01/16/04 07/01/12 INC.

(B) (C) (D) (E) (F) GROSS COST OR EXPENSE OF SALES PRICE OTHER BASIS SALE DEPREC. GAIN OR LOSS

99. 1,050. 0. 1,050. 99.

NET GAIN OR LOSS FROM SALE OF ASSETS 34,237.

CAPITAL GAINS DIVIDENDS FROM PART IV 0.

TOTAL TO FORM 990-PF, PART I, LINE 6A 34,237.

FORM 990-PF LEGAL FEES STATEMENT 4

(A) (B) (C) (D) EXPENSES NET INVEST- ADJUSTED CHARITABLE DESCRIPTION PER BOOKS MENT INCOME NET INCOME PURPOSES

LEGAL FEES 19,892. 0. 0. 10,696.

TO FM 990-PF, PG 1, LN 16A 19,892. 0. 0. 10,696.

FORM 990-PF ACCOUNTING FEES STATEMENT 5

(A) (B) (C) (D) EXPENSES NET INVEST- ADJUSTED CHARITABLE DESCRIPTION PER BOOKS MENT INCOME NET INCOME PURPOSES

ACCOUNTING EXPENSES 71,630. 0. 0. 64,467.

TO FORM 990-PF, PG 1, LN 16B 71,630. 0. 0. 64,467.

16 STATEMENT(S) 3, 4, 5 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9 827 1 THE LAWRENCE ELLISON FO•ATION (FKA TH • 94-3269827

FORM 990-PF OTHER PROFESSIONAL FEES STATEMENT 6

(A) (B) (C) (D) EXPENSES NET INVEST- ADJUSTED CHARITABLE DESCRIPTION PER BOOKS MENT INCOME NET INCOME PURPOSES

SCIENTIFIC ADVISOR FEES 161,500. 0. 0. 161,500. CONSULTING EXPENSES 25,019. 0. 0. 21,266.

TO FORM 990-PF, PG 1, LN 16C 186,519. 0. 0. 182,766.

FORM 990-PF TAXES STATEMENT 7

(A) (B) (C) (D) EXPENSES NET INVEST- ADJUSTED CHARITABLE DESCRIPTION PER BOOKS MENT INCOME NET INCOME PURPOSES

FEDERAL EXCISE TAX 915,000. 0. 0. 915,000. PAYROLL TAXES 36,225. 0. 0. 30,791.

TO FORM 990-PF, PG 1, LN 18 951,225. 0. 0. 945,791.

FORM 990-PF OTHER EXPENSES STATEMENT 8

(A) (B) (C) (D) EXPENSES NET INVEST- ADJUSTED CHARITABLE DESCRIPTION PER BOOKS MENT INCOME NET INCOME PURPOSES

OFFICE EXPENSE 31,666 . 0. 0. 26,916. GRANT PUBLICITY 10,162. 0. 0. 10,162. MISCELLANEOUS 765. 0. 0. 0. INSURANCE 9,823 . 0. 0. 8,350. INTERNET 4,559. 0. 0. 3,875. PAYROLL PROCESSING FEES 3,727. 0. 0. 3,168. DIRECT CHARITABLE EXP. - SYMPOSIUMS 287,599. 0. 0 . 287,599. GRANT MANAGEMENT SYSTEM EXPENSE 14,400. 0. 0. 14,400. FILING FEES 985. 0. 0. 0. MEMBERSHIP DUES 10,000. 0. 0. 10,000.

TO FORM 990-PF, PG 1, LN 23 373,686 . 0. 0. 364,470.

17 STATEMENT(S) 6, 7, 8 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 ------THE LAWRENCE ELLISON Fc ATION (FKA TH • 94-3269827

FORM 990-PF DEPRECIATION OF ASSETS NOT HELD FOR INVESTMENT STATEMENT 9

COST OR ACCUMULATED DESCRIPTION OTHER BASIS DEPRECIATION BOOK VALUE

FURNITURE 2,930. 2,930. 0. FURNITURE 2,775. 2,775. 0. TELEPHONE SYSTEM 5,355. 5,355. 0. FURNITURE 880. 880. 0. FURNITURE 798. 798. 0. COMPUTER EQUIP. - DELL DIMENSION 8400 SERIES 1,910. 1,910. 0. OFFICE FURNITURE 3,260. 3,260. 0. COMPUTER EQUIPMENT - DELL INSPIRON 700M 1,486 . 1,486. 0. COMPUTER EQUIPMENT - DELL INSPIRON 700M 1,087. 1,087. 0. COMPUTER EQUIP. - DELL INSPIRON 9400 1,793. 1,793. 0. FURNITURE 3,527. 2,772. 755. TELEPHONE SYSTEM ADDITION 1,294. 1,017. 277. COMPUTER EQUIP. - DELL PE 1900 SERVER 3,725. 3,725. 0. COMPUTER EQUIP. - OPTIPLEX 740 MINITOWER 1,042. 1,042. 0. COMPUTER EQUIP. - MACBOOK 13/2.4/2X 1GB/250/SD 2,147. 1,770. 377. COMPUTER EQUIP. - SONICWALL TZ 180 1,192. 1,101. 91. COMPUTER EQUIP. - DELL OPTIPLEX 360 754. 472. 282. COMPUTER EQUIP. - DELL OPTIPLEX 360 825. 413. 412. COMPUTER EQUIP. - HP COMPAQ 6000 PRO 700. 210. 490. COMPUTER EQUIP. - HP COMPAQ 6000 PRO 700. 210. 490. COMPUTER EQUIP. - HP COMPAQ 6000 PRO 700. 210. 490. SHELVING 1,123. 20. 1,103. TELEPHONE SYSTEM 1,221. 22. 1,199. WINDOW BL INDS 1,349. 24. 1,325.

TOTAL TO FM 990-PF, PART II, LN 14 42,573. 35,282. 7,291.

18 STATEMENT(S) 9 14251031 731920 9827 2012. 04 0 30 THE LAWRENCE E LL ISON FOUNDA 98 27 1 THE LAWRENCE ELLISON FOSATION (FKA TH • 94-3269827

FORM 990-PF OTHER ASSETS STATEMENT 10

BEGINNING OF END OF YEAR FAIR MARKET DESCRIPTION YR BOOK VALUE BOOK VALUE VALUE

ORGANIZATION COSTS 25,504. 25,504. 0. DEPOSITS 0. 22,868. 22,868.

TO FORM 990-PF, PART II, LINE 15 25,504. 48,372. 22,868.

FORM 990-PF OTHER LIABILITIES STATEMENT 11

DESCRIPTION BOY AMOUNT EOY AMOUNT

PENSION PAYABLE 2,316. 1,364. FSA PAYABLE 1,152. 1,853.

TOTAL TO FORM 990-PF, PART II, LINE 22 3,468. 3,217.

19 STATEMENT(S) 10, 11 14251031 731920 9827 2012. 04 0 30 THE LAWRENC E ELLISON FO UNDA 9827 1 • • The Lawrence Ellison Foundation 94-3269827

Statement Pursuant To Reg . Section 53.4945-5(d)

1. The name and address of the grantee is: Reach to Teach, 10 Barley Mow Passage, Chiswick, London, W4 4PH.

2. The first payment under the original grant agreement dated December 20, 2007 was made in January 2008, which was for $2,000 , 000. In 2010, a second payment of $1,000 , 000 was made . In 2011 , a third and final payment under the original grant agreement totaling $2,000 , 000 was made.

A payment of $500,000 and $4,000,000 was made on November 27, 2012 and December 20, 2012, respectively, pursuant to a new grant agreement dated April 30, 2012.

3. The grants made pursuant to the original grant agreement disclosed in item #2 above constitute payments of a grant totaling $5,000,000. An addendum to the original grant agreement, dated July 2, 2009, provided for an additional grant amount of $3,874,000, but no payments were made towards the additional grant. Rather, a new $5,000,000 grant agreement was signed on April 30, 2012, which superseded the $3,874,000 grant per the addendum.

Under the original grant agreement, the grantee, a charity organized and registered in the United Kingdom, provided through its wholly owned companies educational opportunities to children in the remote tribal areas of rural India, where there is typically little or no educational infrastructure. Under the new grant agreement dated April 30, 2012, the grantee has since discontinued any and all operations of such other companies and itself provides any funding to third parties and undertakes such infrastructure projects.

The purpose of the grants are to (a) fund costs of establishing and managing and operating activities of the grantee, (b) make donations to third parties that have objectives that are consistent with the charitable purposes of the grantee and (c) fund increased provision of services to charities by the grantee.

4. Based on the most recent report received from the grantee, $4,826,000 of the original $5,000,000 grant has been spent as of June 30, 2013 in accordance with the terms of the grant agreement. Based on that same report, none of the $4,500,000 grant paid under the new $5,000,000 grant agreement had been spent as of June 30, 2013.

5. The grantee has not diverted any portion of the funds granted from the purpose of the grant, to the knowledge of the grantor.

6. The dates of recent reports received from the grantee are as follows: March 31, 2012, September 30, 2012 and September 30, 2013.

7. The grantee's financial statements for the 12-month period ended March 31, 2012 were audited by an independent auditor and were found to give a true and fair view, in accordance with UK GAAP, of the state of the grantee's affairs. The grantee's financial statements for the 12 month period ended March 31, 2013 are currently being audited by an independent auditor but the final audit report is still pending. Accordingly, the final results of the independent audit for the period ending March 31, 2013 are not yet known.

STATEMENT(S) 12 2012 DEPRECIATION AND AMORTIZATION REPORT FORM 990-PF PAGE 1 990-PF

Asset Date Line Unadjusted Bus % Reduction In Basis For Accumulated Current Current Year No Description Acquired Method Life No Cost Or Basis Excl Basis Depreciation Depreciation Sec 179 Deduction

FURNITURE & FIXTURES

100 (D FU.RNtTURE 12 1 9 L 7.00 16 7 f542. 7x542. 7r542. 0.

105 (D)FURNITURE 09 8 01 L 7.00 16 1,290. 1,290. 1,290. 0.

110 (D)FU_RN!TURL 10 6 1 L 7.00 16 2 f312. 2,312. 2,r312. 0. 0 115 (D)FURNITURE 11 01 01 L 7.00 16 2,243. 2,243. 2,243. 0.

120 URNI URE it 6 1 L 7.00 16 2x930. 2, 9.30. 2x930. 0.

125 (D)FURNITURE 07 6 02 L 7.00 16 1,057. 1,057. 1,057. 0.

130 FURNITURE 12 31 2 L 7.00 16 2x775. 2,775. 2e775. 0.

140 FURNITURE 12 10 02 SL 7.00 16 880. 880. 880. 0.

141 (b)FURNMU .E 12 10 )2 L 7.00 16 650. 650. 650. 0.

145 FURNITURE 12 10 02 SL 7.00 16 798. 798. 798. 0.

150 (D)FURNITURE 12 31 )2 L 7.00 16 1x749. 1,749. 1e749. 0.

160 OFFICE FURNITURE 01 16 04 SL 7.00 17 3,260. 3,260. 3,260. 0. 0

161 (D}FURNI RE )1 16 )4 L 7.00 17 1x050. 1x050. IrO50. 0.

162 (D)FURNITURE 01 16 04 SL 7.00 17 207. 207. 207. 0.

195 FURNITURE )3 19 )7 L 7.00 17 3f527. 31527. 21,268. 504.

270 SHELVING 11 14 12 L 7.00 19C 1,123. 1,123. 20.

275 IN OW BLINDS 11 8 12 L 7 . D0 19 1 ,, 349. 1 ,04 9. 24. 1 228102 05-01-12 (D) • Asset disposed • ITC, Section 179, Salvage, Bonus, Commercial Revitalization Deduction 24 2012 DEPRECIATION AND AMORTIZATION REPORT FORM 990-PF PAGE 1 990-PF

Asset Date Line Unadjusted Bus % Reduction In Basis For Accumulated Current Current Year No Description Acquired Method Life No Cost Or Basis Excl Basis Depreciation Depreciation Sec 179 Deduction

* 990-PF PG 1 TOT FURNITURE & FIXTUR 34,742. 0. 34,742. 31,011. 0. 548. Q H INERY & QUIPMENT

135 TELEPHONE SYSTEM 02 01 02 SL 7.00 16 5,355. 5,355. 5,355. 0. TELEPHONE SYSTEM 200 ADDITION 4 5 7 L 7.00 17 lx294. 1,294. 832. 185.

274 TELEPHONE SYSTEM 11 8 12 L 7.00 19C 1,221. 1,221. 22. * 990-PF Prp, I TOT CHINERY & EQUI?M 7f870. 0. 7x870. 6x187. ON 207.

THER OMPUTER EQU l? , - 155 ELL DIMENSION 8400 9 15 4 L 5.00 17 If910. 1x910. 1.910. 0. OMPUTER EQUIPMENT 165 DELL INSPIRON 700 04 1 05 L 5.00 17 1,486. 1,486. 1,486. 0. QMPUTER EQUIPMENT 170 1ELL fNSPIRON 700 )6 2 )5 L 5.00 17 Ix087. 1,07. I.x087. 0. (D)COMPUTER 175 EQUIPMENT - DELL D1 12 13 05 L 5.00 17 1,239. 1,239. 1,239. 0. (D) COMPUTER EQUIP. 180 DELL DIMENSION 51 2 6 L 5.00 17 ir27l. 1,271. 1x271. 0. OMPUTER EQUIP. - 185 ELL INSPIRON 9400 04 07 06 SL 5.00 17 1,793. 1,793. 1,793. 0. 0 (D)COMPUTER EQUIP. 190 DELL DIMENSION 51 8 4 6 L 5.00 17 1.078. 1,078. IrO78. 0. OMPUTER EQUIP. - 205 ELL PE 1900 SERVE 04 09 07 L 5.00 17 3,725. 3,725. 3,353. 372. (D)COMPUTER EQUIP. 210 OPPIPLEX 740 MINI 4 9 7 L 5.00 17 I.x042. 1,042. 936. 106. OMPUTER EQUIP. - 215 PTIPLEX 740 MINIT 04 09 07 L 5.00 17 1,042. 1,042. 936. 106. OMPUTER EQUIP. - 220 CROOK 13/2.4/2X1 12 17 8 L 5.00 17 2 f 147. 2447. 1 ,, .341A 429. 05-01°-12 (D) - Asset disposed ITC, Section 179 , Salvage, Bonus, Commercial Revitalization Deduction 25 2012 DEPRECIATION AND AMORTIZATION REPORT FORM 990-PF PAGE 1 990-PF

Asset Date Line Unadjusted Bus % Reduction In Basis For Accumulated Current Current Year No Description Acquired Method Life No Cost Or Basis Excl Basis Depreciation Depreciation Sec 179 Deduction

(D)COMPUTER 225 OFTWARE - BCL EAS 04 16 08 167 36M 43 1,499. 1,499. 1,499. 0. OMPUTER EQUIP. - 230 WNICWALL TZ 180 )6 11 )8 $L 5.00 17 1x192. 1x192. 863. 238. (D)COMPUTER EQUIP. 235 DELL OPTIPLEX 360 10 1 09 L 5.00 17 754. 754. 321. 94. O PUTPR EQUIP. -- 240 ELL OPTIPLEX 360 10 1 9 L 5.00 17 754. 754. 321. 151. (D)COMPUTER EQUIP. 245 - DELL OPTIPLEX 360 01 0 10 L 5.00 17 825. 825. 248. 83. OMPUTER EQUIP. - 250 ELLOPTIPLEX 360 1 0 10 L 5.00 17 825. 825. 248. 165. OMPUTER EQUIP. - 255 1P COMPAQ 6000 PRO 04 7 11 L 5.00 17 700. 700. 70. 140. O PUTER EQUIP. - 260 HP COMPAQ 6000 PRO 4 7 11 L 5.00 17 700. 700. 70. 140. OMPUTER EQUIP. - 265 HP COMPAQ 6000 PRO 04 7 11 L 5.00 17 700. 700. 70. 140. * 990-PF PG I TOT 'HER 25 f769. 0. 251769. 20x140. D. 2x164. * GRAND TOTAL 990-PF PG 1 DEPR & 68,381. 0. 68,381. 57,338. 0. 2,919.

05-0022 (D) • Asset disposed • ITC, Section 179 , Salvage, Bonus, Commercial Revitalization Deduction 26 • •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid Durinci the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount Senior Scholars In Aaing

Tom Misteli, Ph.D. Molecular Mechanisms of Aging-related c/o NIH - National Cancer Institute None N/A $148,392 Cancer Formation Bethesda, MD 20892

William Sonntag, Ph.D. Early metabolic programming of specific c/o Univ. of Oklahoma Health Sci. Ctr. None N/A hypothalamic nuclei by IGF-1: Effects on $2,000 Oklahoma City, OK 73104 age-related disease and lifespan

Alejandro Sanchez Alvarado, Ph.D. do Stowers Institute for Medical Research None N/A Negligible senescence $225,239 Kansas City, MO 64110-2262 Regenerative potential of organs with age, Claude Lechene, M.D. studied with high-resolution quantitative c/o Brigham and Women's Hospital None N/A $251,250 imaging of stable isotopes after in vivo Boston, MA 02115 DNA labeling

Junko Oshima, M.D., Ph.D. c/o University of Washington None N/A Telomere, lamin and progeroid syndromes $234,000 Seattle, WA 98195

Andrew Marks, M.D. c/o Columbia University None N/A Role of intracellular calcium leak in aging $240,000 New York, NY 10032

Novel epigenetic mechanism underlying Julie Andersen, Ph.D. affects of elevated alpha-synuclein levels: c/o Buck Institute for Research on Aging None N/A $291,000 implications for aging and Parkinson's Novato, CA 94945 disease

Richard Morimoto, Ph.D. c/o Northwestern University None N/A The Proteostasis Network of Healthy Aging $228,750 Evanston, IL 60208

Causes and consequences of the aging- Judith Frydman, Ph.D. associated decline in cellular protein c/o Stanford University None N/A $237,000 homeostasis, protein folding and quality Stanford, CA 94305 control

Peter Dervan , Ph.D. Small Molecule Inhibition of NF kappa B c/o California Institute of Technology None N/A $232,370 Mediated Activity in the Aging Cell Pasadena, CA 91125

Grigori Enikolopov, Ph.D. Division-coupled differentiation of stem c/o Cold Spring Harbor Laboratory None N/A cells driving age-related decline in $252,000 Cold Spring Harbor, NY 11724 neurogenesis

Beverly Paigen, Ph.D. c/o The Jackson Laboratory None N/A Testing genes that may affect lifespan $261,000 Bar Harbor, ME 04609

Michael Rosbash, Ph.D. Sleep and Aging in Drosophila: Cause and c/o Brandeis University None N/A $237,000 Effect Waltham, MA 02454-9110

Page 1 of 21 STATEMENT A • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Siu Sylvia Lee, Ph.D. Probing the epigenetic determinants of do Cornell University None N/A $238,500 longevity in C elegans . Ithaca, NY 14850

Eric Baehrecke, Ph.D. Role of autophagy and bioenergetics in c/o University of Massachusetts None N/A $246,750 stem cell maintenance and aging Worcester, MA 01545

Ajit Varki, M.D. Mouse Models of Human-Specific c/o University of California at San Diego None N/A Mechanisms of Aging and Chronic $231,750 La Jolla, CA 92093 Inflammation

Or Gozani, M.D. Role of lysine methylation at chromatin in do Stanford University None N/A $240,000 senescence-associated cellular programs Stanford, CA 94305

David Holtzman, M.D. Sleep, aging, and Alzheimer's disease do Washington University in St. Louis None N/A (AD): Regulation of AD-associated proteins $228,000 St. Louis, MO 63110 by sleep, aging, and orexin

Martin Walsh, Ph.D. Long non-coding RNAs as epigenetic c/o Mount Sinai School of Medicine None N/A $254, 250 modulators of cellular aging New York, NY 10029-6574

Bruce Lahn, Ph.D. Investigating the role of gene occlusion in c/o The University of Chicago None N/A $234,000 cellular aging Chicago, IL 60637

Peter Rabinovitch, M.D., Ph.D. Protein translation, abundance and c/o University of Washington None N/A turnover in genetic models of altered $231,128 Seattle, WA 98195 mTOR signaling

William Sonntag, Ph.D. Early metabolic programming of specific c/o Univ. of Oklahoma Health Sci. Ctr. None N/A hypothalamic nuclei by IGF-1: Effects on $222,000 Oklahoma City, OK 73104 age-related disease and lifespan

Daniel Bogenhagen, M.D. Mitochondrial DNA Nucleoid Organization c/o Stony Brook University None N/A Promotes Age-Related Mitorhondrial* $235,500 Stony Brook, NY 11794 Dysfunction

Matthew Meselson, Ph.D. do Harvard University None N/A Aging in Bdelloid Rotifers $240,750 Cambridge, MA 02138

Nicholas Spitzer, Ph.D. Sensory Stimulation-Dependent do University of California at San Diego None N/A Neurotransmitter Respecification in the $223,167 La Jolla, CA 92093 Aging Brain

T. Keith Blackwell, M.D, Ph.D. How TOR signaling influences SKN-1/Nrf c/o Joslin Diabetes Center None N/A stress defenses , stress resistance, and $242,250 Boston, MA 02215 longevity

Page 2 of 21 STATEMENT A •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Liza Pon, Ph.D. Mitochondrial-cytoskeletal interactions and c/o Columbia University None N/A $241,500 New York, NY 10032

Todd E Golde, M.D., Ph.D Proteinopathy induced Neuronal c/o University of Florida None N/A $219,750 Senescence and Inflammation Gainesville, FL 32611

Junhyong Kim, Ph.D. Genome Biology of Single Neuron Function c/o University of Pennsylvania None N/A $233,609 and its Modulation with Age Philadelphia, PA 19104

Gary Churchill, Ph.D. Aging Research Using the Diversity c/o The Jackson Laboratory None N/A $269,550 Outbred Mice Bar Harbor, ME 04609

Tom Wandless, Ph.D. Cytosolic and Nuclear Protein Quality c/o Stanford University None N/A $233,575 Control Stanford , CA 94305

Haifan Lin, Ph.D. Piwi-piRNA Mechanism in Maintaining c/o Yale University None N/A $248,250 Genome Integrity and Longevity New Haven, CT 06520

Sally Temple, Ph.D. Lineage studies of age-related changes in c/o Regenerative Research Foundation None N/A $270,000 the neural stem cell niche Rensselaer, NY 12144-3452

David Sabatini, M.D., Ph.D. The Role of the Mammalian Stem Cell c/o Whitehead Institute for Biomedical Research None N/A $292,500 Niche in Aging Cambridge, MA 02142-1479

Pietro De Camilli, M.D. c/o Yale University None N/A PI(4,5)P2 metabolism in the aging brain $249,250 New Haven, CT 06520

Joel Buxbaum, M.D. Defining the genetics of Body Temperature c/o The Scripps Research Institute None N/A $284,250 and its relationship to Human Longevity La Jolla, CA 92037

Jayaknshna Ambati, M.D. Somaticis Retrotransposition as a Driver of c/o University of Kentucky Research Foundation None N/A $222,750 Lexington , KY 40506-0057

Yixian Zheng, Ph.D. Investigate the cause and effect of aging- c/o Carnegie Institution of Washington None N/A associated Iamin-B loss on chronic $234,000 Baltimore, MD 21218 inflammation and lifespan

Aviv Bergman, Ph.D. The role of epigenetic mechanisms in c/o Albert Einstein Coll. of Med. of Yeshiva Univ. None N/A aging: an evolutionary systems biology $242,959 Bronx, NY 10461 approach

Page 3 of 21 STATEMENT A •

• THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Junying Yuan, Ph.D. c/o Harvard Medical School None N/A RIP1 kinase, TNFalpha and aging $254,250 Boston, MA 02115

Scott Pletcher, Ph.D. Molecular dissection of neurosensory do University of Michigan None N/A circuits that specify health and longevity in $231,991 Ann Arbor, Ml 48109-1274 Drosophila

Richard Miller, M .D., Ph.D. Two New Methods That Extend Maximal c/o University of Michigan None N/A $233,115 Lifespan in Mice Ann Arbor, Ml 48109-1274

Robert Roeder, Ph D. Mechanistic study of transcriptional c/o The Rockefeller University None N/A regulation of stress-responsive Sestnn $254,250 New York, NY 10065 genes by tumor suppressor p53

Brigid Hogan, Ph.D. Alveolar epithelial stem cells and the aging c/o Duke University None N/A $235,500 lung Durham, NC 27705

Richard Mann, Ph.D. The decline of motor coordination during c/o Columbia University None N/A 9 $216,000 New York , NY 10032

Victor Ambros, Ph.D. MicroRNA pathways and stress resistance c/o University of Massachusetts Medical School None N/A $249,374 in C. elegans Worcester, MA 01605

Martin Hetzer, Ph.D. Role of Nuclear Pore Complex c/o Salk Institute for Biological Studies None N/A $284,100 Deterioration in Aging La Jolla, CA 92186-5800

Carla Shatz, Ph.D. c/o Stanford University None N/A Restonng Plasticity to the Adult Brain $248,100 Stanford, CA 94305

Shelley Berger, Ph.D. High-throughput investigation of chromatin c/o University of Pennsylvania None N/A and epigenetic pathways regulating cellular $240,000 Philadelphia, PA 19104 lifespan

Craig Crews, Ph.D. Cellular Regeneration: Reversing the Aging c/o Yale University None N/A $249,188 Process New Haven, CT 06520

Arthur Horwich, M.D. Lipofuscin production in motor neurons of c/o Yale School of Medicine None N/A $197,498 normal and ALS mice New Haven, CT 06510

Brendan Manning, Ph.D. Determining the genetic and metabolic c/o Harvard School of Public Health None N/A relationship between the major longevity $236,100 Boston, MA 02115 pathways in mammals

Page 4 of 21 STATEMENT A • E

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Bruce Hay, Ph.D. Mitochondrial DNA quality control and c/o California Institute of Technology None N/A aging: promoting selective removal of $254,500 Pasadena , CA 91125 mutant mitochondrial genomes

Thomas Schwarz, Ph.D. Mitochondrial Distribution, Neuropathology, c/o Children's Hospital Boston None N/A $261,000 and Degenerative Disorders Boston, MA 02115-5724

Holly Van Remmen, Ph.D. Mechanisms by which mitochondrial c/o Univ. of Texas Health Sci. Ctr. San Antonio None N/A electron transport chain mutations lead to $224,250 San Antonio, TX 78229-3900 increased longevity in mice

Jeremy Nathans, M.D.,Ph.D. The mouse retina as a platform to c/o The Johns Hopkins University None N/A investigate microvascular plasticity in the $243,000 Baltimore, MD 21218 adult central nervous system

John Abrams, Ph.D. Chromatin interactions assembled through c/o Univ. of Texas SW Medical Center at Dallas None N/A long-range p53 enhancer activity in normal $238,500 Dallas , TX 75390-9020 and pathologic aging

Leona D . Samson, Ph.D. DNA Base Excision Repair, Parp1, Tissue c/o Massachusetts Institute of Technology None N/A $240,750 Degeneration and Aging Cambridge, MA 02139-4307

Shawn Ahmed, Ph.D Novel pathways that promote germ cell c/o The University of North Carolina None N/A $226 , 238 immortality Chapel Hill, NC 27599-1350

Brian Kennedy, Ph.D Enhanced longevity associated with altered c/o Buck Institute for Research on Aging None N/A $291,001 ribosome function Novato, CA 94945

Andre Nussenzweig, Ph.D. Linking nuclear DNA damage and do NIH - National Cancer Institute None N/A epigenetic changes to stem cell and $150,000 Bethesda , MD 20892 mitochondrial decline during aging

James Kirkland, M.D., Ph.D. Aging and Adult "Stem" Cell c/o Mayo Clinic None N/A $236,550 Transplantation : Seed vs. Soil Rochester, MN 55905

Gary Struhl, Ph.D. Control of tissue mass during aging by c/o Columbia University None N/A morphogens, steroid hormones and the $235,800 New York, NY 10032 Hippo tumor suppressor pathway

Angelika Amon, Ph.D. Rejuvenation mechanisms during germ cell do Massachusetts Institute of Technology None N/A $240,750 formation. Cambridge, MA 02139-4307

Steven Burden, Ph.D. Mechanisms for maintaining c/o New York University School of Medicine None N/A neuromuscular synapses and preventing $254,250 New York, NY 10016 sarocopenia

Page 5 of 21 STATEMENT A 0 •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Amita Sehgal, Ph.D. Contribution of impaired circadian c/o University of Pennsylvania None N/A $235,200 physiology to aging Philadelphia , PA 19104

Yang Shi, Ph.D. The molecular mechanisms of c/o Children's Hospital Boston None N/A transgenerational epigenetic inheritance of $261,000 Boston, MA 02115-5724 longevity

Visualizing forgetful neurons: A first study Mark Schnitzer, Ph.D. on the long-term stability and instability of c/o Stanford University None N/A $228,245 cellular representations of spatial memory Stanford, CA 94305 in aged brains

Identification of Components and Pathways Michael Green, M.D. Involved in Replicative Senescence c/o University of Massachusetts None N/A $246,750 through Genome-Wide RNA Interference Worcester, MA 01545 Screens Fred H. Gage, Ph.D. Mechanisms of Age related decline in Adult Salk Institute for Biological Studies None N/A $285,750 do neurogenesis La Jolla, CA 92186-5800

Juan Carlos Izpisua Belmonte, Ph.D. Using iPSC from HGPS patient fibroblasts c/o Salk Institute for Biological Studies None N/A to study aging and dedifferentiation of $285,750 La Jolla, CA 92186-5800 senescence cells

Ronald Evans, Ph.D. The Protective Role of Estrogen Related c/o Salk Institute for Biological Studies None N/A Receptor Gamma in Frailty, Obesity and $285,750 La Jolla, CA 92186-5800 Vascular Disease

Marc Tessier-Lavigne, Ph.D. Elucidating the role of pathogenic tau in c/o The Rockefeller University None N/A neurodegeneration using neurons $254,250 New York, NY 10065 generated from patient-derived stem cells

Thomas Tullius, Ph.D. Genome damage and aging : whole- c/o Boston University None N/A genome maps of owdative DNA lesions at $243,750 Boston , MA 02215 single-nucleotide resolution

Charles Zuker, Ph.D. Mammalian Taste Cell Differentiation, c/o Columbia University None N/A $241,500 Renewal and Maintenance New York, NY 10032

Richard Hanson, Ph.D. The Role of Energy Metabolism in the c/o Case Western Reserve University None N/A Prolonged Life Span of the PEPCK-Cmus $233,790 Cleveland, OH 44106-7037 Mouse

Robert Haselkom, Ph.D. Determination of lifetimes of differentiated c/o The University of Chicago None N/A $234,000 cells in filamentous cyanobacteria Chicago, IL 60637

Page 6 of 21 STATEMENT A • •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Gerard Karsenty, M.D., Ph. D. Molecular bases of the anti-aging functions c/o Columbia University None N/A $240,000 of the bone derived hormone osteocalcin New York, NY 10032

Holly Brown- Borg , Ph.D. The role of growth hormone and c/o University of North Dakota None N/A methionine in stress resistance and life $202,500 Grand Forks, ND 58203 span

Lee Rubin, Ph.D. Discovery of Small Molecules to Treat c/o Harvard University None N/A $253,500 Skeletal Muscle Sarcopenia Cambridge, MA 02138

George Daley, M.D., Ph.D. The Lin28/let-7 pathway in age-related c/o Children's Hospital Boston None N/A $261,000 disease Boston , MA 02115-5724

Marc Tessier-Lavigne, Ph.D. Chromatin Architecture and Gene c/o Memorial Sloan-Kettering Cancer Center None N/A $172,875 Regulation in Aging Cells New York, NY 10065

Jean-Pierre Issa, M.D. c/o Temple University None N/A Epigenetic Drift as a Modifier of Lifespan $229,500 Philadelphia, PA 19122

Kazuko Nishikura, Ph D Editing of telomeric repeat RNAs and its do The Wistar Institute None N/A $250,277 role in control of telomere shortening Philadelphia, PA 19104-4265

Martin Brand, Ph.D. Compounds that suppress mitochondrial c/o Buck Institute for Research on Aging None N/A reactive oxygen species production but not $291,000 Novato, CA 94945 ATP synthesis in cells

Lee Zou, Ph.D. Roles of the Non-Coding RNA TERRA in c/o Massachusetts General Hospital None N/A Telomere Maintenance, Checkpoint $252,120 Boston , MA 02114 Response, and Aging

Richard Goodman, M.D., Ph.D. Adult newborn hippocampal neurons: c/o Oregon Health and Science University None N/A $231.000 effects of aging and exercise Portland, OR 97239

Michael Karin, Ph.D. Role of Sestnns and autophagy in c/o University of California at San Diego None N/A $232,500 prevention of age-related myopathies La Jolla, CA 92093

Susan Strome, Ph.D. Elucidating the mechanism of lifespan c/o University of California, Santa Cruz None N/A extension following somatic acquisition of $209,321 Santa Cruz, CA 95064 germ cell traits in C. elegans

Page 7 of 21 STATEMENT A • •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Howard Chang, Ph.D. Reversal of aging: Mechanisms and c/o Stanford University None N/A $205,165 consequences Stanford, CA 94305

Jonathan Dworkin, Ph.D. Role of microbiota in the aging of a model c/o Columbia University None N/A $241,500 organism New York, NY 10032

Se-Jin Lee, M.D., Ph.D. Extension of life span in mice by c/o The Johns Hopkins University None N/A stimulation of anabolic pathways in skeletal $243,000 Baltimore, MD 21218 muscle

David Toczyski, Ph.D Connections between the DNA damage c/o University of California at San Francisco None N/A checkpoint pathway, metabolism and $234,875 San Francisco, CA 94143 aging.

Anne Brunet, Ph.D. Role and mode of action of longevity genes c/o Stanford University None N/A in reprogramming somatic cells into $232,791 Stanford , CA 94305 pluripotent stem cells

Vera Gorbunova, Ph.D. Anticancer mechanisms in a long-lived c/o University of Rochester None N/A $231,749 rodent, the naked mole-rat Rochester , NY 14627

J. David Sweatt, Ph.D. c/o The University of Alabama at Birmingham None N/A An epigenetic hypothesis of cognitive aging $219,750 Birmingham , AL 35294-1250

Bradley Olwin, Ph.D. Reprogramming Muscle Stem Cells to c/o University of Colorado at Boulder None N/A $228,750 Resist Aging Boulder, CO 80309

Nancy Bonini, Ph.D. Genes & Pathways that Modulate Neural do University of Pennsylvania None N/A $232, 458 Decline with Age Philadelphia , PA 19104

Eric Schon, Ph.D. Mitochondria-associated membranes in c/o Columbia University None N/A $241,466 Alzheimer disease New York, NY 10032

John Lisman, Ph.D. Mechanism of synaptic weakening in c/o Brandeis University None N/A $235,550 Alzheimer's and Aging: role of CaMKII Waltham, MA 02454-9110

Konstantin Khrapko, Ph.D. Somatic mtDNA mutations in the aging c/o Beth Israel Deaconess Medical Center None N/A process and longevity: an interspecies $261,000 Boston, MA 02215 comparison

Ben Barres , M.D., Ph.D. Does complement cascade mediated c/o Stanford University None N/A synapse elimination drive cognitive decline $238,610 Stanford, CA 94305 in the aging brain?

Page 8 of 21 STATEMENT A •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount James Eberwine, Ph.D. Systems analysis of dendntic mRNA c/o University of Pennsylvania None N/A $240,000 abundances and translation during aging Philadelphia, PA 19104

Iva Greenwald, Ph.D. Regulation of Braf signaling by the ubiquitin c/o Columbia University None N/A ligase Fbw7: implications for aging, protein $233,941 New York, NY 10032 homeostasis, and cancer

Elaine Fuchs, Ph.D. Dissecting the Molecular Effects of Aging c/o The Rockefeller University None N/A $254,250 on Skin Stem Cells New York, NY 10065

SUBTOTAL - Senior Scholars in Aging $25,012,227

New Scholars in Aging

Elucidating how the cell protects the Richard Gardner , Ph.D. nucleus from the accumulation and do University of Washington None N/A $100,000 aggregation of damaged and misfolded Seattle, WA 98195 proteins

Chengkai Dai, M.D., Ph.D. The roles of the stress response in aging c/o The Jackson Laboratory None N/A $100,000 and age related diseases in humans Bar Harbor, ME 04609

Michael Man-, Ph.D. Transcription-coupled Translational do Brandeis University None N/A Regulation in Insulin signaling and $99,903 Waltham, MA 02454-9110 Longevity

David Lombard, M.D, Ph.D. Mitochondnal acetylation in calorie c/o University of Michigan None N/A $100,000 restriction and aging Ann Arbor, MI 48109-1274

Marc Hammarlund, Ph.D. Mechanisms of age-related decline in axon c/o Yale University None N/A $100,000 regeneration New Haven, CT 06520

James Shorter, Ph.D Enhancing Proteostasis to Combat Age- c/o University of Pennsylvania None N/A $100,000 Related Neurodegenerative Disorders Philadelphia, PA 19104

Sean Curran, Ph.D. Molecular genetics of exceptional longevity c/o University of Southern California None N/A $100,000 and survival Los Angeles, CA 90089-8001

Page 9 of 21 STATEMENT A • •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Needhi Bhalla , Ph.D. Nuclear Organization and Regulation of c/o University of California at Santa Cruz None N/A $100,000 Meiotic Recombination Santa Cruz, CA 95064

Elucidating the molecular mechanism of Qingjun Wang, Ph.D. macroautophagy in aging and dietary c/o University of Kentucky Research Foundation None N/A $100,000 restriction utilizing an integrated mouse Lexington, KY 40506-0057 genetic-proteomic approach

Alon Keinan, Ph.D. The X-factor of human aging: Mapping age- c/o Cornell University None N/A $100,000 related disease genes on Chromosome X Ithaca, NY 14850

Kara Bernstein,. Ph.D. Using live cell imaging to uncover how c/o University of Pittsburgh None N/A misrepair of double-strand breaks $100,000 Pittsburgh, PA 15219 contributes to aging

Sandra Encalada, Ph.D. Dissecting the Relationships Between c/o The Scripps Research Institute None N/A Aging, Axonal Transport Regulation, and $100,000 La Jolla, CA 92037 Aggregation

Long Cai, Ph.D. Studying aging in single yeast cells by c/o California Institute of Technology None N/A $99,529 super resolution microscopy Pasadena , CA 91125

Stephen Waggoner, Ph.D. Effect of aging on natural killer cell c/o University of Massachusetts None N/A $100,000 regulation of T cells in viral pathogenesis Worcester, MA 01545

Marrn Boppart, Sc.D. Utilization of Alpha7 Integrin-Denved Stem c/o University of Illinois at Urbana-Champaign None N/A Cells as Therapy for the Alleviation of $100,000 Champaign, IL 61820 Sarcopenia

Clifford Wang, Ph.D. A stochastic oscillator to determine c/o Stanford University None N/A whether fluctuations in gene expression $100.000 Stanford, CA 94305 cause aging

Jason Bielas, Ph.D. Mechanisms of Human Mitochondrial c/o Fred Hutchinson Cancer Research Center None N/A $100,000 Mutagenesis in Aging and Disease Seattle, WA 98109

Harlan Robins, Ph.D. Age-dependent changes in the human T- do Fred Hutchinson Cancer Research Center None N/A $100,000 cell repertoire Seattle, WA 98109

Andrew Samuelson, Ph.D. Functional Genomics and Genetics of c/o University of Rochester None N/A $100,000 Aging in Caenorhabditis Elegans Rochester, NY 14627

Page 10 of 21 STATEMENT A •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Joseph Baur, Ph.D. The Role of NAD Metabolism in Caloric c/o University of Pennsylvania None N/A $100,000 Restriction and Obesity Philadelphia, PA 19104

Reconstruction of an aging-related Zhengdong Zhang, Ph.D. subnetwork and analysis of its modularity c/o Albert Einstein Coll. of Med. of Yeshiva Univ. None N/A $100,000 and evolution in human and other Bronx, NY 10461 mammals

Meng Wang, M.D., Ph.D. Modeling lipid dynamics during aging via c/o Baylor College of Medicine None N/A $100,000 label-free SRS imaging Houston , TX 77030

Daniel Mucida, Ph.D. Influence of intestinal microbiota in immune c/o The Rockefeller University None N/A $100,000 senescence New York, NY 10065

Matthew Hams, Ph.D. Zebrafish as a genetic model to understand c/o Children's Hospital Boston None N/A the physiological mechanisms of vertebrate $100,000 Boston, MA 02115-5724 aging

William Ja, Ph.D. Nutritional modulation of Drosophila c/o The Scripps Research Institute None N/A $100,000 lifespan La Jolla, CA 92037

Gizem Donmez, Ph.D Investigating the Heat Shock Response in c/o Tufts University None N/A $100,000 Aging Mammalian Brain Boston, MA 02111

Rajat Singh, M.D. Hypothalamic autophagy and the metabolic c/o Albert Einstein Coll. of Med. of Yeshiva Univ. None N/A $100,000 syndrome of aging Bronx, NY 10461

William Mair, Ph.D. Uncoupling Positive and Negative Effects c/o Harvard University None N/A $100,000 of Dietary Restriction Cambridge, MA 02138

Shawn Ferguson, Ph.D. Identification of mechanisms regulating c/o Yale University None N/A lysosome homeostasis and their role in $100,000 New Haven, CT 06520 protecting neurons against aging

Michael Petrascheck, Ph.D. c/o The Scripps Research Institute None N/A Developing dietary restriction mimetics $100,000 La Jolla, CA 92037

Jeremy Sanford, Ph.D. Investigating the Role of Toxic RNA in c/o University of California at Santa Cruz None N/A $100,000 Aging-Related Disease Santa Cruz, CA 95064

Page 11 of 21 STATEMENT A 0

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Chi-Wei Lu, Ph.D. Increased cancer susceptibility in aging c/o Univ. of Med. and Dent. of New Jersey None N/A $100,000 tissue an embryonic stem cell approach Newark, NJ 07107

Christian Schlieker, Ph.D. Deciphering the Nuclear Quality Control c/o Yale University None N/A $100,000 Network and its Relation to Aging New Haven, CT 06520

Marius Wemig, M.D. Direct conversion of aging fibroblasts into c/o Stanford University None N/A $100,000 neurons Stanford, CA 94305

R. Luke Wiseman, Ph.D. Characterizing the aging-dependent decline c/o The Scripps Research Institute None N/A in the capacity for mitochondria to protect $100,000 La Jolla, CA 92037 their proteome

Kan Cao, Ph.D. c/o University of Maryland None N/A Alternative Splicing in Cellular Senescence $100,000 College Park, MD 20742

Arjumand Ghazi, Ph D. microRNAs and Lipophilic-Hormonal c/o University of Pittsburgh None N/A Pathways that Relay Reproductive Signals $100,000 Pittsburgh, PA 15219 to Control Aging

Eric Bennett, Ph.D. Ubiquitin-dependent control mechanisms c/o University of California at San Diego None N/A $100,000 governing cellular senescence and aging La Jolla, CA 92093

Amar Sahay, Ph.D. Reversing age related impairments in c/o Massachusetts General Hospital None N/A pattern separation to improve episodic $100,000 Boston, MA 02114 memory formation

Dion Dickman, Ph.D. Homeostatic Synaptic Plasticity and the c/o University of Southern California None N/A $100,000 Aging Nervous System Los Angeles, CA 90089-8001

Judd Villen, Ph.D. due oanalysis of lifespan extension c/o University of Washington None N/A to $100,000 due to dietary restriction or TOR inhibition Seattle, WA 98195

Marcia Haigis, Ph.D. Investigating the role of SIRT4 in the Harvard Medical School None N/A $100,000 c/o regulation of obesity and lifespan Boston, MA 02115

Shu-Bing Qian, Ph.D. TheRe Role of Stress Signaling in mTOR c/o Cornell University None N/A $100,000 Regulation and Aging Ithaca, NY 14850

L. Ryan Baugh, Ph.D. Feedback Regulation of Insulin-like c/o Duke University None N/A $99,062 Signaling Durham, NC 27705

Page 12 of 21 STATEMENT A • 0

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Jonathan Wanagat, M.D., Ph.D. p ly-targeted utations s and c/o University of California at Los Angeles None N/A $100,000 the Spectrum of mtDNA Mutations Los Angeles, CA 90095-1406

Matthew Hibbs, Ph.D. c/o The Jackson Laboratory None N/A Mammalian Somatic Mutations and Aging $100,000 Bar Harbor, ME 04609

Timur Yusufzai, Ph.D. Characterization of Novel Enzymes c/o Dana-Farber Cancer Institute None N/A in $100,000 Involvedlved Premature Aging Boston, MA 02115-6013

Jin Li, Ph.D. c/o Stanford University None N/A Age-Dependent Changes of RNA Editing $100,000 Stanford, CA 94305

Sundeep Kalantry, Ph D. Investigating the Role of Epigenetic c/o University of Michigan None N/A $100,000 Dysregulation in Mammalian Aging Ann Arbor, MI 48109-1274

Michael Elliott, Ph D. Defining molecular alterations in apoptotic c/o University of Rochester None N/A cell clearance signaling in the aging $100,000 Rochester, NY 14627 immune system

Claire Benard, Ph.D. Protecting the Nervous System from Aging c/o University of Massachusetts None N/A $100,000 and Neurodegeneration Worcester, MA 01545

Andrew Xiao, Ph.D. Investigating the role of epigenetic c/o Yale University None N/A mechanisms for genome integrity $100,000 New Haven, CT 06520 maintenance in stem cells during aging

Rebecca Butcher, Ph.D. Small-molecule cues that control c/o University of Florida None N/A development, metabolism, and lifespan in $100,000 Gainesville, FL 32611 C. elegans

Johnathan Whetstine, Ph.D. The Histone Lysine Tri-demethylase JMJD- c/o Massachusetts General Hospital None N/A 2 Impacts C. elegans Longevity Through $100,000 Boston, MA 02114 Genomic Integrity

Kelly Dyer, Ph.D. Effects of the Y chromosome on None N/A $100,000 c/o The University of Georgia senescence Athens, GA 30602-7411

Jim Wilhelm, Ph.D. The role of RNA granules in stem cell c/o University of California at San Diego None N/A maintenance during aging and resistance $100,000 La Jolla, CA 92093 to oxidative stress

Page 13 of 21 STATEMENT A E 0

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Diane Cabelof, Ph.D Endogenous retrotransposable elements c/o Wayne State University None N/A $100,000 promote genomic ility with Detroit, MI 48202 instability age

Mayumi Ito, Ph . D. Epithelial microenvironment in melanocyte c/o New York University School of Medicine None N/A $100,000 stem cell aging New York, NY 10016

Alessandra Sacco, Ph.D. Role of telomere shortening in skeletal c/o Sanford-Burnham Medical Research Institute None N/A $100,000 muscle aging La Jolla, CA 92037

Xin Jin, Ph.D. Action learning and nigrostriatal circuits in c/o Salk Institute for Biological Studies None N/A $100,000 the senescent brain La Jolla, CA 92186-5800

Brian Burton, Ph.D. The Dynamic Human Microbiome and its c/o Harvard University None N/A $100,000 Role in Aging Cambridge, MA 02138

Cassandra Extavour, Ph.D. A Model System for Understanding c/o Harvard University None N/A $99,996 Germline Stem Cell Aging in vivo Cambridge, MA 02138

Amy Ralston, Ph.D. Examining the impact of aging on cellular c/o University of at Santa None N/A California Cruz reprogramming $100,000 Santa Cruz, CA 95064

Alexander Soukas, M.D., Ph.D. Genetics of aging and fat metabolism in c/o Massachusetts General Hospital None N/A $100,000 Caenorhabditis elegans. Boston, MA 02114

Christian Petersen, Ph.D. c/o Northwestern University None N/A Control of Wnt signaling in regeneration $100,000 Evanston, IL 60208

Dana Miller, Ph.D Understanding the cts Hydrogen c/o University of Washington None N/A on $100,000 Sulfide o nroteinProteinP Homeostasis and Aging Seattle, WA 98195

Jun Hee Lee, Ph.D. Sestnns at the crossroads between c/o University of Michigan None N/A $100,000 nutrition, aging and metabolism Ann Arbor, MI 48109-1274

Bernardo Lemos, Ph.D. Genomic architecture of germline-soma do Harvard University None N/A $100,000 feedbacks during aging Cambridge, MA 02138

Page 14 of 21 STATEMENT A c J •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Timothy Lu, M.D., Ph .D Unlocking Complex Aging Mechanisms c/o Massachusetts Institute of Technology None N/A $100,000 with Synthetic Biology Cambridge, MA 02139-4307

Peter Kharchenko, Ph.D. Epigenetic maintenance of repetitive c/o Harvard Medical School None N/A $98,297 elements in aging cells Boston, MA 02115

Markus Seeliger, Ph.D. Age related changes in the substrate c/o Stony Brook University None N/A $100 , 000 spectrum of the ubiquitin system Stony Brook, NY 11794

Katalin Fees-Toth, M.D., Ph.D. A systems biology approach to aging: c/o California Institute of Technology None N/A Dissecting changes in gene expression $100,000 Pasadena, CA 91125 during cellular senescence

Erica Smith, Ph.D. Stem cells and longevity in the planarian c/o Northwestern University None N/A $100,000 Schmidtea mediterranea Evanston, IL 60208

Danica Chen, Ph.D. Molecular Mechanism of the Dietary c/o University of California at Berkeley None N/A $100,000 Restriction Response Berkeley, CA 94704-5940

Scott Boyd, Ph.D. B cell and T cell Determinants of Influenza c/o Stanford University None N/A $100,000 Vaccine Responses in the Elderly Stanford, CA 94305

Darren Baker, Ph.D. Senescent cell clearance in healthspan c/o Mayo Clinic None N/A $100,000 extension Rochester, MN 55905

Daniel Smith, Jr., Ph.D. Preservation of glucose homeostatis with c/o The University of Alabama at Birmingham None N/A acarbose for lifespan extension: Acarbose $100,000 Birmingham , AL 35294-1250 as a calorie restriction mimetic

Tim Koves, Ph.D. Incomplete Beta-Oxidation of Fatty Acids c/o Duke University None N/A $98,370 and Age Associated Muscle Dysfunction Durham , NC 27705

Andrew Brack, Ph.D. Intrisic and extrinsic regulation of muscle c/o Massachusetts General Hospital None N/A $100,000 stem cell homeostasis during aging Boston, MA 02114

Vlad Denic, Ph D. Mechanistic Analysis of Age-Induced c/o Harvard University None N/A $100,000 Changes in Protein Disaggregation Cambridge, MA 02138

Page 15 of 21 STATEMENT A • •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Steven Kosak, Ph.D. Interaction of lamin A/C and telomeres in c/o Northwestern University None N/A $100,000 human embryonic stem cell fate Evanston, IL 60208

Veronica Galvan, Ph.D. c/o Univ. of Texas Health Sci. Ctr. San Antonio None N/A Neuronal mTOR in Mammalian Aging $99,889 San Antonio, TX 78229-3900

Zoltan Arany, M.D., Ph.D Regulation of Angiogenesis in Aging by c/o Beth Israel Deaconess Medical Center None N/A $100,000 SIRT1 and PGC-1alpha Boston, MA 02215

Chun-Li Zhang, Ph.D. A Genomics Approach to Understanding c/o Univ. of Texas SW Medical Center at Dallas None N/A $100,000 Neural Stem Cell Aging Dallas , TX 75390-9020

Xiaoyong Yang, Ph.D. O-GIcNAc Signaling in Caloric Restriction c/o Yale University None N/A $100,000 and Aging New Haven, CT 06520

Andrew Yoo, Ph.D. Cellular modeling of brain aging using c/o Washington University in St. Louis None N/A $100,000 human neurons converted from fibroblasts St. Louis, MO 63110

Examining the impact of increased Cole Haynes, Ph.D. mitochondrial unfolded protein response c/o Memorial Sloan-Kettering Cancer Center None N/A $100,000 signaling on aging and age-associated New York, NY 10065 stress

Yael Niv, Ph D. Interactions between learning and attention c/o Princeton University None N/A $100,000 across the lifespan Princeton, NJ 08540

Stefan Leutgeb, Ph.D Memory allocation after neural circuit c/o University of California at San Diego None N/A reorganization in the young and aged $100,000 La Jolla, CA 92093 hippocampus

Andrew Steele, Ph.D. SIRT1 in the neurobiology of calorie c/o California Institute of Technology None N/A $100,000 restriction Pasadena , CA 91125

Matthew Rockman, Ph.D. do New York University None N/A Genetical Genomics of Aging in C. elegans $100,000 New York, NY 10012

Beth Stevens, Ph.D. Investigation of the Glial and Immune c/o Children' s Hospital Boston None N/A Signals that Promote Synapse Loss and $100,000 Boston , MA 02115-5724 Dysfunction in the Aged CNS

Page 16 of 21 STATEMENT A • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

Qinglian Liu, Ph.D Structural and functional studies of Hsp70 c/o Virginia Commonwealth University None N/A chaperone systems: implications in aging $100,000 Richmond, VA 23298 and neurodegenerative diseases

Ji-Hye Paik, Ph.D. Molecular Mechanism of FOXO-dependant c/o Weill Medical College of Cornell University None N/A $100 ,000 NSC Fate Decision in Aging Brain New York, NY 10065

James Holaska, Ph.D. Nuclear envelope regulation of stem cell c/o The University of Chicago None N/A $100 differentiation , 000 Chicago, IL 60637

Ahmet Yildiz, Ph.D. Understanding the Role of Functional do University of California at Berkeley None N/A Telomere Structure in Aging by Single $100,000 Berkeley, CA 94704-5940 Molecule Imaging

Wenwei Hu, Ph.D. The impact of SNPs in the p53 pathway c/o Univ. of Med. and Dent. of New Jersey None N/A $100,000 upon aging and longevity Newark, NJ 07107

Viviana Perez, Ph.D. Does protein homeostasis determine c/o Oregon State University None N/A $100 , 000 longevity? A comparative biology approach Corvallis, OR 97339

Jun Li, Ph D. Genetic analysis of a rat model of aerobic c/o University of Michigan None N/A $99,973 capacity and aging Ann Arbor, MI 48109-1274

SUBTOTAL - New Scholars, Aging $9,895,019

Institutional Awardees (Aging Conferences)

2012 Gordon Research Conference on Gordon Research Conferences Public Biology of Aging - "Genetic , epigenetic , None $14,970 West Kingston, RI 02892 Charity inflammatory, and metabolic origins of aging"

Keystone Symposia Public 2012 Keystone Symposium on "Sirtuins in None $6,000 Silverthome, CO 80498 Charity Metabolism, Aging, and Disease"

Gordon Research Conferences Public 2012 Gordon Research Conference on None $5,000 West Kingston, RI 02892 Charity "DNA Damage, Mutation and Cancer"

Buck Institute for Research on Aging Public 2012 "Brain Diseases and Molecular None $5,000 Novato, CA 94945 Charity Machines Conference

Page 17 of 21 STATEMENT A S •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

2012 C elegans Topic Meeting on "Aging, University of Wisconsin Public None Metabolism, Stress, Pathogenesis, and $10,000 Madison, W 153706-1490 Charity Small RNAs"

11th International Symposium of University of North Dakota Public None Neurobiology and Neuroendocrinology of $7,500 Grand Forks, ND 58203 Charity Aging

2012 FASEB summer research conference FASEB Public None on "Posttranscriptional control of gene $5,500 Bethesda, MD 20814 Charity expression "

Gordon Research Conference on "The Gordon Research Conferences Public None Biology of Post-Transcriptional Gene $10,000 West Kingston, RI 02892 Charity Regulation"

Gordon Research Conferences Public 2012 Gordon Research Conference on None $2,500 West Kingston, RI 02892 Charity "The Cell Biology of the Neuron"

2012 GRC on Mutagenesis - "A Delicate Gordon Research Conferences Public None Balance: Cellular Mutation Pathways in $10,000 West Kingston, RI 02892 Charity Genetic Stability and Disease"

Keystone Symposia Public 2012 Keystone Symposium on "Aging and None $10,000 Silverthorne, CO 80498 Charity Diseases of Aging"

41st Annual American Aging Association American Aging Association Public None Conference - "Interventions Now: Targets, $5,000 Media, PA 19063 Charity Tactics, and Timing"

FASEB Public 2012 FASEB summer research conference None $10,000 Bethesda, MD 20814 Charity on "Protein Folding"

2012 Annual Meeting of the Gerontological The Gerontological Society of America Public None Society of America - Biological Sciences $5,000 Washington, DC 20005 Charity Section

International Mammalian Genome Soc., Inc. Public None Mouse Genetics 2012 Conference $10,000 Oak Ridge, TN 37831-2009 Charity

Univ. of Texas San Antonio Nathan Shock Texas r. San Antonio Public None Center Conference on "Mouse Heaithspan: $7,500 Chanty San Antonio , TX 78229-3900 Why Lifespan is no Longer Enough"

SUBTOTAL - Institutional Awardees (Aging Conferences ) $123,970

Page 18 of 21 STATEMENT A • fJ

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount Institutional Awardees (Other Aging Awards)

American Federation for Aging Research Public None Julie Martin AFAR/EMF Mid-Career Award $302,500 New York, NY 10018 Charity

American Federation for Aging Research Public Continued support Julie Martin AFAR/EMF None $907,500 New York, NY 10018 Charity Mid-Career Awards 2010 - 2014

Cold Spring Harbor Laboratory Public 2012 Postgraduate Workshop on Cognitive None $15,000 Cold Spring Harbor, NY 11724 Charity Aging

Marine Biological Laboratory Public The continued support of the Biology of None $263,697 Woods Hole, MA 02543 Charity Aging course from 2012-2014

American Federation for Aging Research Public Continued support of the AFAR Senior None $951,300 New York, NY 10018 Charity Postdoctoral Research Program

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $57, 000 Baltimore, MD 21218 Charity Monica Brenni (MRC)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $57, 000 Baltimore, MD 21218 Charity Hannah Seidel (Univ. of Wisconsin)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $57 , 000 Baltimore, MD 21218 Charity Kimberley Tu (Univ.of Utah)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. Ylli None $57 ,000 Baltimore, MD 21218 Charity Doksani (Rockefeller Univ.)

SUBTOTAL - Institutional Awardees (Other Aging Awards) $2,667,997

Senior Scholars in Neuroscience

Nirao Shah, Ph.D. Dissecting the molecular and neural control c/o University of California at San Francisco None N/A $231,750 of aggression San Francisco, CA 94143-0962

Lisa Stowers, Ph.D. Sensory-initiated approach to identify, map, c/o The Scripps Research Institute None N/A and study the relevant neurons in the brain $284,250 La Jolla, CA 92037 that promote aggression

Page 19 of 21 STATEMENT A • •

THE LAWRENCE ELLISON FOUNDATION (FKATHE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

David Anderson, Ph.D. Identification of the neural substrates of c/o California Institute of Technology None N/A genetic and environmental influences on $246,000 Pasadena, CA 91125 aggression in mice

Kenneth Kendler, Ph.D. Genetic and Environmental Risk Factors c/o Virginia Commonwealth University None N/A for Violent Criminal Behavior : A Swedish $199,373 Richmond, VA 23298 National Study

Cornelia Bargmann, Ph.D. The effect of social context on decision- c/o The Rockefeller University None N/A $254,250 making New York, NY 10065

SUBTOTAL - Senior Scholars in Neuroscience $1,215,623

Institutional Awardees (Other Neuroscience Awards)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $57,000 Baltimore, MD 21218 Charity Jamie Fitzgerald ( Rockefeller Univ.)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. Mark None $57,000 Baltimore, MD 21218 Charity Sheffield (Northwestern Univ.)

Massachusetts Institute of Technology Public Cognitive Neuroscience of Autism and None $2,000,000 Cambridge, MA 02139-4307 Chanty Dyslexia

SUBTOTAL - Institutional Awardees (Other Neuroscience Awards) $2,114,000

Institutional Awardees (Other Programs)

Tom Lantos Fdn. For Human Rights Justice Public None Tom Lantos Foundation Endowment Fund $1,000,000 Concord, NH 03301-4001 Chanty

Reach to Teach None N/A Continued support of Reach to Teach $500,000 Chiswick, London, W4 4PH

Reach to Teach None N/A Continued support of Reach to Teach $4,000,000 Chiswick, London, W4 4PH

SUBTOTAL - Institutional Awardees (Other Neuroscience Awards) $5,500,000

Page 20 of 21 STATEMENT A • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Paid During the Year 2012

Recipient Name and Address Relationship Status Purpose of Grant Amount

TOTAL GRANTS PAID, 2012 $46,528,836

Less Returned Grant Monies, 2012 ($109,996)

NET GRANTS PAID, 2012 $46,418,840

Page 21 of 21 STATEMENT A 0

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Senior Scholars In Agin

Alejandro Sanchez Alvarado, Ph.D. c/o Stowers Institute for Medical Research None N/A Negligible senescence $223,583 Kansas City, MO 64110-2262

Richard Hanson, Ph.D. The Role of Energy Metabolism in the c/o Case Western Reserve University None N/A Prolonged Life Span of the PEPCK- $235,500 Cleveland , OH 44106-7037 Cmus Mouse

David Holtzman, M.D. Sleep, aging, and Alzheimer's disease c/o Washington University in St. Louis None N/A (AD): Regulation of AD-associated $228,000 St. Louis, MO 63110 proteins by sleep, aging, and ores in

Nicholas Spitzer, Ph.D. Sensory Stimulation-Dependent c/o University of California at San Diego None N/A Neurotransmitter Respecification in the $222,235 La Jolla, CA 92093 Aging Brain

Michael Karin, Ph.D. Role of Sestrins and autophagy in c/o University of California at San Diego None N/A $232,500 prevention of age-related myopathies La Jolla, CA 92093

T. Keith Blackwell, M.D., Ph.D. How TOR signaling influences SKN- c/o Joslin Diabetes Center None N/A 1/Nrl stress defenses, stress resistance , $242,250 Boston, MA 02215 and longevity

Fred H Gage, Ph D. Mechanisms of Age related decline in c/o Salk Institute for Biological Studies None N/A $285,750 Adult neurogenesis La Jolla, CA 92186-5800

Tom Misteli, Ph.D. Molecular Mechanisms of Aging-related c/o NIH - National Cancer Institute None N/A $299,484 Cancer Formation Bethesda, MD 20892

Liza Pon, Ph.D. Mitochondrial-cytoskeletal interactions c/o Columbia University None N/A $241,500 and aging New York, NY 10032

Todd E Golde, M.D., Ph.D Proteinopathy induced Neuronal c/o University of Florida None N/A $219,750 Senescence and Inflammation Gainesville, FL 32611

Page 1 of 18 STATEMENT B •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Scott Pletcher, Ph.D. Molecular dissection of neurosensory c/o University of Michigan None N/A circuits that specify health and longevity $233,160 Ann Arbor, Ml 48109-1274 in Drosophila

Martin Walsh, Ph D. Long non-coding RNAs as epigenetic c/o Mount Sinai School of Medicine None N/A $254,250 modulators of cellular aging New York, NY 10029-6574

Michael Rosbash, Ph.D Sleep and Aging in Drosophila: Cause c/o Brandeis University None N/A $237,000 and Effect Waltham, MA 02454-9110

Junhyong Kim, Ph.D. Genome Biology of Single Neuron c/o University of Pennsylvania None N/A $232,689 Function and its Modulation with Age Philadelphia, PA 19104

J David Sweatt , Ph D An epigenetic hypothesis of cognitive c/o The University of Alabama at Birmingham None N/A $219,750 aging Birmingham , AL 35294-1250

Gary Churchill, Ph.D. Aging Research Using the Diversity c/o The Jackson Laboratory None N/A $269,550 Outhred Mice Bar Harbor, ME 04609

Richard Miller, M.D., Ph D. Two New Methods That Extend c/o University of Michigan None N/A $232,935 Maximal Lifespan in Mice Ann Arbor, MI 48109-1274

Robert Haselkom, Ph.D. Determination of lifetimes of c/o The University of Chicago None N/A differentiated cells in filamentous $234,000 Chicago, IL 60637 cyanobacteria

Bruce Lahn, Ph.D. Investigating the role of gene occlusion c/o The University of Chicago None N/A $234,000 in cellular aging Chicago, IL 60637

Juan Carlos Izpisua Belmonte, Ph.D. Using iPSC from HGPS patient c/o Salk Institute for Biological Studies None N/A fibroblasts to study aging and $285,750 La Jolla, CA 92186-5800 dedifferentiation of senescence cells

Peter Rabinovitch, M.D., Ph.D. Protein translation, abundance and c/o University of Washington None N/A turnover in genetic models of altered $233,918 Seattle, WA 98195 mTOR signaling

Page 2 of 18 STATEMENT B •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Shelley Berger, Ph.D. High-throughput investigation of c/o University of Pennsylvania None N/A chromatin and epigenetic pathways $240,000 Philadelphia, PA 19104 regulating cellular lifespan

Siu Sylvia Lee, Ph.D. Probing the epigenetic determinants of c/o Cornell University None N/A $238,500 longevity in C elegans. Ithaca, NY 14850

Holly Van Remmen, Ph.D. Mechanisms by which mitochondrial c/o Univ. of Texas Health Sci. Ctr. San Antonio None N/A electron transport chain mutations lead $224,250 San Antonio, TX 78229-3900 to increased longevity in mice

Tom Wandless, Ph.D. Cytosolic and Nuclear Protein Quality Stanford University None N/A $233,383 c/o Control Stanford, CA 94305

Konstantin Khrapko, Ph.D. Somatic mtDNA mutations in the aging c/o Beth Israel Deaconess Medical Center None N/A process and longevity: an interspecies $261,000 Boston, MA 02215 comparison

Haifan Lin, Ph.D. Piwi-piRNA Mechanism in Maintaining c/o Yale University None N/A $248,250 Genome Integrity and Longevity New Haven , CT 06520

Andrew Marks, M.D. Role of intracellular calcium leak in c/o Columbia University None N/A $480,000 New York, NY 10032

Jeremy Nathans, M.D.,Ph.D. The mouse retina as a platform to c/o The Johns Hopkins University None N/A investigate microvascular plasticity in $486,000 Baltimore, MD 21218 the adult central nervous system

Richard Morimoto, Ph.D. The Proteostasis Network of Healthy c/o Northwestern University None N/A 9 $457,500 Evanston, IL 60208

Lee Zou, Ph.D. Roles of the Non-Coding RNA TERRA c/o Massachusetts General Hospital None N/A in Telomere Maintenance, Checkpoint $495,360 Boston , MA 02114 Response, and Aging

Page 3 of 18 STATEMENT B LJ LJ

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL Novel epigenetic mechanism underlying Julie Andersen, Ph.D. affects of elevated alpha-synuclein c/o Buck Institute for Research on Aging None N/A $582,000 levels: implications for aging and Novato , CA 94945 Parkinson 's disease

Ben Barres, M.D., Ph.D. Does complement cascade mediated c/o Stanford University None N/A synapse elimination drive cognitive $477,220 Stanford, CA 94305 decline in the aging brain?

Andre Nussenzweig, Ph.D. Linking nuclear DNA damage and c/o NIH - National Cancer Institute None N/A epigenetic changes to stem cell and $300,000 Bethesda, MD 20892 mitochondrial decline during aging

William Sonntag, Ph.D. Early metabolic programming of specific c/o Univ. of Oklahoma Health Sci. Ctr. None N/A hypothalamic nuclei by IGF-1 • Effects $444,000 Oklahoma City, OK 73104 on age-related disease and lifespan

Sally Temple, Ph.D Lineage studies of age-related changes c/o Regenerative Research Foundation None N/A $540,000 in the neural stem cell niche Rensselaer, NY 12144-3452

Robert Roeder, Ph D. Mechanistic study of transcriptional c/o The Rockefeller University None N/A regulation of stress-responsive Sestrin $508,500 New York, NY 10065 genes by tumor suppressor p53

Lee Rubin, Ph D. Discovery of Small Molecules to Treat c/o Harvard University None N/A $507,000 Skeletal Muscle Sarcopenia Cambridge, MA 02138

Se-Jin Lee, M.D., Ph.D. Extension of life span in mice by c/o The Johns Hopkins University None N/A stimulation of anabolic pathways in $486,000 Baltimore , MD 21218 skeletal muscle

David Sabatini, M.D., Ph.D. The Role of the Mammalian Stem Cell c/o Whitehead Institute for Biomedical Research None N/A $585,000 Niche in Aging Cambridge, MA 02142-1479

James Kirkland, M D., Ph.D. Aging and Adult "Stem" Cell c/o Mayo Clinic None N/A $473,100 Transplantation: Seed vs. Soil Rochester, MN 55905

Page 4 of 18 STATEMENT B LJ •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Gerard Karsenty, M.D., Ph.D. Molecular bases of the anti-aging c/o Columbia University None N/A functions of the bone derived hormone $480,000 New York, NY 10032 osteocalcin

John Abrams, Ph.D. Chromatin interactions assembled c/o Univ. of Texas SW Med. Ctr. Dallas None N/A through long-range p53 enhancer $477,000 Dallas, TX 75390-9020 activity in normal and pathologic aging

Eric Baehrecke, Ph.D. Role of autophagy and bioenergetics in c/o University of Massachusetts None N/A $493,500 stem celll maintenance and aging Worcester, MA 01545

Ronald Evans, Ph.D. The Protective Role of Estrogen c/o Salk Institute for Biological Studies None N/A Related Receptor Gamma in Frailty, $571,500 La Jolla, CA 92186-5800 Obesity and Vascular Disease

Craig Crews, Ph.D. Cellular Regeneration: Reversing the c/o Yale University None N/A $499,500 Aging Process New Haven, CT 06520

Pietro De Camilli, M.D. c/o Yale University None N/A PI(4,5)P2 metabolism in the aging brain $499,500 New Haven, CT 06520

Joel Buxbaum, M.D Defining the genetics of Body c% The Scripps Research Institute None N/A Temperature and its relationship to $568,500 La Jolla, CA 92037 Human Longevity

Gary Struhl, Ph.D. Control of tissue mass during aging by c/o Columbia University None N/A morphogens, steroid hormones and the $471,600 New York, NY 10032 Hippo tumor suppressor pathway

James Eberwine, Ph.D. Systems analysis of dendritic mRNA c/o University of Pennsylvania None N/A abundances and translation during $480,000 Philadelphia, PA 19104 aging

Causes and consequences of the aging- Judith Frydman, Ph.D. associated decline in cellular protein c% Stanford University None N/A $474,000 homeostasis, protein folding and quality Stanford, CA 94305 control

George Daley, M.D., Ph.D. The Lin28/let-7 pathway in age-related c/o Children's Hospital Boston None N/A $522,000 disease Boston , MA 02115-5724

Page 5 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Richard Goodman, M.D., Ph D. Adult newborn hippocampal neurons: None N/A $693,000 c/o Oregon Health and Science University effects of aging and exercise Portland, OR 97239

Jayakrishna Ambati, M.D. Somatic Retrotransposition as a Driver c/o University of Kentucky Research Foundation None N/A $668,250 of Aging Lexington, KY 40506-0057

Angelika Amon, Ph.D. Rejuvenation mechanisms during germ c/o Massachusetts Institute of Technology None N/A $722,250 cell formation. Cambridge, MA 02139-4307

Steven Burden, Ph.D. Mechanisms for maintaining c/o New York University School of Medicine None N/A neuromuscular synapses and $762,750 New York, NY 10016 preventing sarocopenia

Amita Sehgal, Ph.D. Contribution of impaired circadian c/o University of Pennsylvania None N/A $715,200 physiology to aging Philadelphia, PA 19104

Yang Shi, Ph.D. The molecular mechanisms of c/o Children's Hospital Boston None N/A transgenerational epigenetic inheritance $783,000 Boston , MA 02115-5724 of longevity

Brigid Hogan, Ph.D. Alveolar epithelial stem cells and the c/o Duke University None N/A $706,500 aging lung Durham , NC 27705

Richard Mann, Ph.D. The decline of motor coordination c/o Columbia University None N/A $666,000 during aging New York, NY 10032

Iva Greenwald, Ph.D. Regulation of Braf signaling by the c/o Columbia University None N/A ubiquitin ligase Fbw7 : implications for $714,912 New York, NY 10032 aging , protein homeostasis, and cancer

Page 6 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Mark Ptashne , M.D.,Ph.D. Chromatin Architecture and Gene c/o Memorial Sloan-Kettering Cancer Center None N/A $544,991 Regulation in Aging Cells New York, NY 10065

Elaine Fuchs, Ph.D. Dissecting the Molecular Effects of c/o The Rockefeller University None N/A $762,750 Aging on Skin Stem Cells New York, NY 10065

Arthur Horwich, M.D. Lipofuscin production in motor neurons c/o Yale School of Medicine None N/A $600,239 of normal and ALS mice New Haven , CT 06510

Elucidating the role of pathogenic tau in Marc Tessier-Lavigne, Ph.D. neurodegeneration using neurons c/o The Rockefeller University None N/A $762,750 generated from patient-derived stem New York, NY 10065 cells

Visualizing forgetful neurons. A first Mark Schnitzer, Ph.D study on the long-term stability and Stanford University None N/A $683,229 c/o instability of cellular representations of Stanford, CA 94305 spatial memory in aged brains

Brendan Manning, Ph.D. Determining the genetic and metabolic c/o Harvard School of Public Health None N/A relationship between the major $726,750 Boston, MA 02115 longevity pathways in mammals

Victor Ambros, Ph.D. MicroRNA pathways and stress c/o University of Massachusetts Medical School None N/A $753,001 resistance in C. elegans Worcester, MA 01605

Leona D. Samson, Ph.D. DNA Base Excision Repair, Parp1, Massachusetts Institute of Technology None N/A $722,250 c/o Tissue Degeneration and Aging Cambridge, MA 02139-4307

Bruce Hay, Ph.D. Mitochondrial DNA quality control and c/o California Institute of Technology None N/A aging: promoting selective removal of $715,500 Pasadena, CA 91125 mutant mitochondrial genomes

Page 7 of 18 STATEMENT B C] •

THE LAWRENCE ELLISON FOUNDATION (FICA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Yuan Zheng, Ph.D. Investigate the cause and effect of c/o Carnegie Institution of Washington None N/A aging-associated Iamin-B loss on $702,000 Baltimore, MD 21218 chronic inflammation and lifespan

Shawn Ahmed, Ph.D. Novel pathways that promote germ cell c/o The University of North Carolina None N/A $678,713 immortality Chapel Hill, NC 27599-1350

Susan Strome, Ph.D Elucidating the mechanism of lifespan c/o University of California, Santa Cruz None N/A extension following somatic acquisition $617,423 Santa Cruz, CA 95064 of germ cell traits in C. elegans

Bradley Olwin, Ph.D. Reprogramming Muscle Stem Cells to c/o University of Colorado at Boulder None N/A $686,250 Resist Aging Boulder, CO 80309

Jean-Pierre Issa, M D. Epigenetic Drift as a Modifier of c/o Temple University None N/A $688,500 Lifespan Philadelphia, PA 19122

Brian Kennedy, Ph D. Enhanced longevity associated with c/o Buck Institute for Research on Aging None N/A $872,999 altered ribosome function Novato, CA 94945

David Toczyski, Ph.D. Connections between the DNA damage c/o University of California at San Francisco None N/A checkpoint pathway, metabolism and $710,625 San Francisco , CA 94143 aging.

SUBTOTAL - Senior Scholars in Aging

New Scholars In Aging

Ji-Hye Paik, Ph.D. Molecular Mechanism of FOXO- c/o Weill Medical College of Cornell University None N/A dependant NSC Fate Decision in Aging $100,000 New York, NY 10065 Brain

Markus Seeliger, Ph.D. Age related changes in the substrate c/o Stony Brook University None N/A $ 100,000 spectrum of the ubiquitin system Stony Brook, NY 11794

Page 8 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

L. Ryan Baugh, Ph.D. Feedback Regulation of Insulin-like c/o Duke University None N/A $99,986 Signaling Durham, NC 27705

Briana Burton, Ph.D. The Dynamic Human Microbiome and c/o Harvard University None N/A $100,000 its Role in Aging Cambridge, MA 02138

Christian Schlieker, Ph.D. Deciphering the Nuclear Quality Control c/o Yale University None N/A $100,000 Network and its Relation to Aging New Haven, CT 06520

Zoltan Arany, M.D., Ph.D Regulation of Angiogenesis in Aging by c/o Beth Israel Deaconess Medical Center None N/A $100,000 SIRT1 and PGC- lalpha Boston, MA 02215

Beth Stevens, Ph.D. Investigation of the Gliaf and Immune c/o Children's Hospital Boston None N/A Signals that Promote Synapse Loss $100,000 Boston , MA 02115-5724 and Dysfunction in the Aged CNS

Diane Cabelof, Ph D. Endogenous retrotransposable c/o Wayne State University None N/A elements promote genomic instability $100,000 Detroit, MI 48202 with age

Mayumi Ito, Ph.D Epithelial microenvironment in c/o New York University School of Medicine None N/A $100,000 melanocyte stem cell aging New York, NY 10016

Andrew Samuelson, Ph.D. Functional Genomics and Genetics of c/o University of Rochester None N/A $100,000 Aging in Caenorhabditis Elegans Rochester , NY 14627

Katalin Fejes-Toth, M.D., Ph.D. A systems biology approach to aging: c/o California Institute of Technology None N/A Dissecting changes in gene expression $100,000 Pasadena , CA 91125 during cellular senescence

Marc Hammarlund, Ph.D. Mechanisms of age-related decline in c/o Yale University None N/A $100,000 axon regeneration New Haven, CT 06520

Page 9 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Jonathan Wanagat, M.D., Ph.D. Mitochondrially-targeted Antioxidants c/o University of California at Los Angeles None N/A $100,000 and the Spectrum of mtDNA Mutations Los Angeles, CA 90095-1406

Cassandra Extavour, Ph.D. A Model System for Understanding c/o Harvard University None N/A $99,993 Germline Stem Cell Aging in vivo Cambridge, MA 02138

Viviana Perez, Ph.D Does protein homeostasis determine c/o Oregon State University None N/A longevity? A comparative biology $100,000 Corvallis, OR 97339 approach

Marius Wemig, M.D. Direct conversion of aging fibroblasts c/o Stanford University None N/A $100,000 into neurons Stanford, CA 94305

Erica Smith, Ph.D. Stem cells and longevity in the planarian c/o Northwestern University None N/A $100,000 Schmidtea mediterranea Evanston, IL 60208

Joseph Baur, Ph.D. The Role of NAD Metabolism in Caloric c/o University of Pennsylvania None N/A $100,000 Restriction and Obesity Philadelphia, PA 19104

Steven Kosak, Ph.D. Interaction of lamin A/C and telomeres c/o Northwestern University None N/A $100,000 in human embryonic stem cell fate Evanston, IL 60208

Elucidating the molecular mechanism of Qingjun Wang, Ph.D. macroautophagy in aging and dietary c/o University of Kentucky Research Foundation None N/A $100,000 restriction utilizing an integrated mouse Lexington, KY 40506-0057 genetic-proteomic approach

Stefan Leutgeb, Ph.D. Memory allocation after neural circuit c/o University of California at San Diego None N/A reorganization in the young and aged $100,000 La Jolla, CA 92093 hippocampus

Veronica Galvan, Ph.D. c/o Univ. of Texas Health Sci. Ctr. San Antonio None N/A Neuronal mTOR in Mammalian Aging $99,997 San Antonio, TX 78229-3900

Page 10 of 18 STATEMENT B • 0

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Amy Ralston, Ph.D. Examining the impact of aging on c/o University of California at Santa Cruz None N/A $100,000 cellular reprogramming Santa Cruz, CA 95064

Jun Li, Ph.D. Genetic analysis of a rat model of c/o University of Michigan None N/A $99,437 aerobic capacity and aging Ann Arbor, MI 48109-1274

Sean Curran, Ph.D. Molecular genetics of exceptional c/o University of Southern California None N/A $200,000 longevity and survival Los Angeles, CA 90089-8001

Reconstruction of an aging-related Zhengdong Zhang, Ph.D. subnetwork and analysis of its c/o Albert Einstein Coll. of Med. of Yeshiva Univ None N/A $200,000 modularity and evolution in human and Bronx, NY 10461 other mammals

Chun-Li Zhang, Ph.D. A Genomics Approach to c/o Univ. of Texas SW Med. Ctr. Dallas None N/A $200,000 Understanding Neural Stem Cell Aging Dallas , TX 75390-9020

Meng Wang , M.D., Ph.D. Modeling lipid dynamics during aging c/o Baylor College of Medicine None N/A $200,000 via label-free SRS imaging Houston , TX 77030

Examining the impact of increased Cole Haynes, Ph.D mitochondrial unfolded protein c/o Memorial Sloan-Kettering Cancer Center None N/A $200,000 response signaling on aging and age- New York, NY 10065 associated stress

Daniel Mucida, Ph.D. Influence of intestinal microbiota in c/o The Rockefeller University None N/A $200,000 immune senescence New York, NY 10065

R. Luke Wiseman, Ph.D. Characterizing the aging-dependent c/o The Scripps Research Institute None N/A decline in the capacity for mitochondria $200,000 La Jolla, CA 92037 to protect their proteome

Page 11 of 18 STATEMENT B 0

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Danica Chen, Ph.D. Molecular Mechanism of the Dietary c/o University of California at Berkeley None N/A $200,000 Restriction Response Berkeley, CA 94704-5940

Matthew Hibbs, Ph D. Mammalian Somatic Mutations and c/o The Jackson Laboratory None N/A $200,000 Aging Bar Harbor, ME 04609

Kan Cao, Ph.D Alternative Splicing in Cellular c/o University of Maryland None N/A $200,000 Senescence College Park, MD 20742

Wenwei Hu, Ph.D. The impact of SNPs in the p53 pathway c/o Univ. of Med. and Dent. of New Jersey None N/A $200,000 upon aging and longevity Newark, NJ 07107

Scott Boyd, Ph.D. B cell and T cell Determinants of c/o Stanford University None N/A Influenza Vaccine Responses in the $200,000 Stanford, CA 94305 Elderly

Alexander Soukas, M.D., Ph D. Genetics of aging and fat metabolism in c/o Massachusetts General Hospital None N/A $200,000 Caenorhabditis elegans. Boston, MA 02114

Matthew Hams, Ph.D. Zebrafish as a genetic model to c/o Children's Hospital Boston None N/A understand the physiological $200,000 Boston, MA 02115-5724 mechanisms of vertebrate aging

Sundeep Kalantry, Ph.D. Investigating the Role of Epigenetic c/o University of Michigan None N/A $200,000 Dysregulation in Mammalian Aging Ann Arbor, MI 48109-1274

William Ja, Ph.D. Nutritional modulation of Drosophila c/o The Scripps Research Institute None N/A $200,000 La Jolla , CA 92037

Timur Yusufzai, Ph.D. Characterization of Novel Enzymes c/o Dana-Farber Cancer Institute None N/A $200,000 Involved in Premature Aging Boston, MA 02115-6013

Page 12 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Darren Baker, Ph.D. Senescent cell clearance in healthspan c/o Mayo Clinic None N/A $200,000 extension Rochester, MN 55905

Michael Elliott, Ph.D Defining molecular alterations in c/o University of Rochester None N/A apoptotic cell clearance signaling in the $200,000 Rochester, NY 14627 aging immune system

Christian Petersen, Ph.D. c/o Northwestern University None N/A Control of Writ signaling in regeneration $200,000 Evanston, IL 60208

Claire Benard, Ph.D. Protecting the Nervous System from c/o University of Massachusetts None N/A $200,000 Aging and Neurodegeneration Worcester, MA 01545

Alessandra Sacco, Ph.D. Role of telomere shortening in skeletal c/o Sanford-Burnham Medical Research Institute None N/A $200,000 muscle aging La Jolla, CA 92037

Dana Miller, Ph.D. Understanding the effects of Hydrogen c/o University of Washington None N/A Sulfide on Protein Homeostasis and $200,000 Seattle, WA 98195 Aging

Yael Niv, Ph.D. Interactions between learning and c/o Princeton University None N/A $200,000 attention across the lifespan Princeton, NJ 08540

Xiaoyong Yang, Ph.D. R-GIcNAc Signaling in Caloric c/o Yale University None N/A $200,000 Restriction andd Aging New Haven, CT 06520

G¢em Donmez, Ph.D. Investigating the Heat Shock Response c/o Tufts University None N/A $300,000 in Aging Mammalian Brain Boston, MA 02111

Page 13 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Rajat Singh, M.D. Hypothalamic autophagy and the C/o Albert Einstein Coll. of Med. of Yeshiva Univ. None N/A $300,000 metabolic syndrome of aging Bronx, NY 10461

Andrew Yoo, Ph.D. Cellular modeling of brain aging using c/o Washington University in St. Louis None N/A human neurons converted from $300,000 St. Louis, MO 63110 fibroblasts

Arjumand Ghazi, Ph.D. microRNAs and Lipophilic-Hormonal c/o University of Pittsburgh None N/A Pathways that Relay Reproductive $300,000 Pittsburgh, PA 15219 Signals to Control Aging

William Mair, Ph.D. Uncoupling Positive and Negative c/o Harvard University None N/A $300,000 Effects of Dietary Restriction Cambridge , MA 02138

Shawn Ferguson, Ph.D. Identification of mechanisms regulating c/o Yale University None N/A lysosome homeostasis and their role in $300,000 New Haven , CT 06520 protecting neurons against aging

Alon Keinan, Ph.D. The X-factor of human aging : Mapping c/o Cornell University None N/A age-related disease genes on $300,000 Ithaca, NY 14850 Chromosome X

Eric Bennett, Ph.D. Ubiquitin-dependent control c/o University of California at San Diego None N/A mechanisms governing cellular $300,000 La Jolla, CA 92093 senescence and aging.

Amar Sahay, Ph.D. Reversing age related impairments in c/o Massachusetts General Hospital None N/A pattern separation to improve episodic $299,995 Boston, MA 02114 memory formation

Andrew Xiao, Ph.D. Investigating the role of epigenetic c/o Yale University None N/A mechanisms for genome integrity $300,000 New Haven , CT 06520 maintenance in stem cells during aging

Michael Petrascheck, Ph.D. c/o The Scripps Research Institute None N/A Developing dietary restriction mimetics $300,000 La Jolla , CA 92037

Page 14 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Aaaroved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Jun Hee Lee, Ph.D. Sestrins at the crossroads between c/o University of Michigan None N/A $300,000 nutrition , aging and metabolism Ann Arbor, MI 48109-1274

Kara Bernstein,. Ph.D. Using live cell imaging to uncover how c/o University of Pittsburgh None N/A misrepair of double-strand breaks $300,000 Pittsburgh, PA 15219 contributes to aging

Bemardo Lemos, Ph.D. Genomic architecture of germline-soma c/o Harvard University None N/A $300,000 feedbacks during aging Cambridge, MA 02138

Preservation of glucose homeostatis Daniel Smith, Jr., Ph.D. with acarbose for lifespan extension: c/o The University of Alabama at Birmingham None N/A $300,000 Acarbose as a calorie restriction Birmingham, AL 35294-1250 mimetic

Xin Jin, Ph.D. Action learning and nigrostriatal circuits c/o Salk Institute for Biological Studies None N/A $300,000 in the senescent brain La Jolla, CA 92186-5800

Dion Dickman, Ph D. Homeostatic Synaptic Plasticity and the c/o University of Southern California None N/A $300,000 Aging Nervous System Los Angeles, CA 90089-8001

Timothy Lu, M.D., Ph.D Unlocking Complex Aging Mechanisms c/o Massachusetts Institute of Technology None N/A $300,000 with Synthetic Biology Cambridge, MA 02139-4307

Sandra Encalada , Ph.D. Dissecting the Relationships Between c/o The Scripps Research Institute None N/A Aging, Axonal Transport Regulation, $300,000 La Jolla, CA 92037 and Aggregation

Judit Villen, Ph.D. Proteomic analysis of lifespan extension c/o University of Washington None N/A due to dietary restriction or TOR $300,000 Seattle, WA 98195 inhibition

Page 15 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FICA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Long Cai, Ph D. Studying aging in single yeast cells by c/o California Institute of Technology None N/A $298,337 super-resolution microscopy Pasadena, CA 91125

Stephen Waggoner, Ph.D. Effect of aging on natural killer cell c/o University of Massachusetts None N/A regulation of T cells in viral $300,000 Worcester, MA 01545 pathogenesis

Jin Li, Ph.D. Age-Dependent Changes of RNA c/o Stanford University None N/A $300,000 Editing Stanford, CA 94305

Rebecca Butcher, Ph.D. Small-molecule cues that control c/o University of Florida None N/A development, metabolism, and lifespan $300,000 Gainesville, FL 32611 in C elegans

Peter Kharchenko, Ph.D. Epigenetic maintenance of repetitive c/o Harvard Medical School None N/A $291,825 elements in aging cells Boston, MA 02115

SUBTOTAL - New Scholars in Aging $14,889,570

Institutional Awardees (Aging Conferences)

Keystone Symposia Public 2013 Keystone Symposium on None $8,000 Silverthome, CO 80498 Charity "Genomic Instability and DNA Repair"

SUBTOTAL - Institutional Awardees (Aging Conferences) $8,000

Institutional Awardees (Other Aging Awards)

American Federation for Aging Research Public Continued support of the AFAR Senior None $951,300 New York, NY 10018 Charity Postdoctoral Research Program

Page 16 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FKA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions ADDroved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

Continued support Julie Martin American Federation for Aging Research Public None AFAR/EMF Mid-Career Awards 2010 - $4,235,000 New York, NY 10018 Charity 2014

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $114,000 Baltimore, MD 21218 Charity Yan Qi (MGH)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $57,000 Baltimore, MD 21218 Charity Ylli Doksani (Rockefeller Univ.)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $114,000 Baltimore, MD 21218 Charity Monica Brenni (MRC)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $114,000 Baltimore, MD 21218 Charity Hannah Seidel (Univ. of Wisconsin)

Marine Biological Laboratory Public The continued support of the Biology of None $535,015 Woods Hole, MA 02543 Charity Aging course from 2012-2014

SUBTOTAL - Institutional Awardees (Other Aging Awards)

Senior Scholars In Neuroscience

Kenneth Kendler, Ph.D. Genetic and Environmental Risk c/o Virginia Commonwealth University None N/A Factors for Violent Criminal Behavior. A $560,994 Richmond, VA 23298 Swedish National Study

Cornelia Bargmann, Ph D. The effect of social context on decision- c/o The Rockefeller University None N/A $762,750 making New York, NY 10065

Nirao Shah, Ph.D. Dissecting the molecular and neural c% University of Califomia at San Francisco None N/A $695,250 control of aggression San Francisco, CA 94143-0962

Lisa Stowers, Ph.D. Sensory-initiated approach to identify, c/o The Scripps Research Institute None N/A map, and study the relevant neurons in $852,750 La Jolla, CA 92037 the brain that promote aggression

Page 17 of 18 STATEMENT B • •

THE LAWRENCE ELLISON FOUNDATION (FICA THE ELLISON MEDICAL FOUNDATION) 94-3269827 Grants & Contributions Approved for Future Payment (as of 12/31/12) Recipient Name and Address Relationship Status Purpose of Grant TOTAL

David Anderson, Ph.D. Identification of the neural substrates of c/o California Institute of Technology None N/A genetic and environmental influences $734,800 Pasadena, CA 91125 on aggression in mice

SUBTOTAL - Senior Scholars in Neuroscience $3,606,544

Institutional Awardees (Neuroscience)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $114,000 Baltimore , MD 21218 Charity Jamie Fitzgerald (Rockefeller Univ.)

Life Sciences Research Foundation Public LSRF Postdoctoral Fellowship for Dr. None $114,000 Baltimore , MD 21218 Charity Mark Sheffield ( Northwestern Univ.)

SUBTOTAL - Institutional Awardees ( Neuroscience ) $228,000

Institutional Awardees (Other Programs)

Reach to Teach None N/A Continued support of Reach to Teach $500,000 Chiswick, London, W4 4PH

SUBTOTAL - Institutional Awardees ( Other Programs) $500,000

TOTAL FUTURE PAYMENTS (as of 12/31/12) oat 014 070

Page 18 of 18 STATEMENT B THE LAWRENCE ELLI& FOUNDATION (FKA THE ELLISc IEDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2

ABOUT I PROGRAMS I EXPLORE AGING RESEARCH I HOW TO APPLY Enter Search Terms

NNO The Ellison Medical Foundation 44]_e A NG'^F`R -1T cor- r OPP :ION

About the Aging Program Award Programs in Aging .)r Senior Scholar in Aging Awards The world' s 60-and-over population increased by more than 12 million persons in >, New Scholar in Aging Awards 1995 alone , reaching a total of 550 million » Conferences and Workshops

By the year 2025, 1 2 billion people will be 60 or older Improvements in health care and x> Infrastructure disease prevention have the potential to create economic benefit to and to dramatically » Courses and Training improve the quality of life of, millions of individuals Significant breakthroughs in !, Other Awards understanding the basic biological processes that underlie aging and age-related diseases are the best hope we have for achieving genuine prevention or amelioration of age-related debilitation and disease

The Ellison Medical Foundation supports basic biomedical research on aging relevant to understanding lifespan development processes and age-related diseases and disabilities The foundation stimulates basic biomedical research in multiple disciplines Specific areas of interest include. but are not limited to

Structural biology • Molecular genetics • Studies with model systems ranging from lower eukaryotes to humans • Inquiries testing the relevance of simpler models to human aging • Genetic epidemiology of aging, candidate longevity genes Aging in the immune system Host defense molecules in aging systems Mechanisms of free radical induced cell aging Mechanisms of aging in various differentiated cell populations • Geneienvironment and gene/gene interactions Integrative physiology • New approaches to age-modulated disease mechanisms

%t:,+ [lie Ellison Medicul1,oundulton e io.1 F Ridgeville cud Phone 301 829-6410 NountAi,v MI,21771-;260 fax 3o1-829 - 6,l13 cc) 2010 Ellison Medical Foundation

Page 1 of 10 STATEMENT C THE LAWRENCE ELLIS FOUNDATION (FKA THE ELLISC&EDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2

ABOUT PROGRAMS I EXPLORE AGING RESEARCH I HOW TO APPLY Enter Search Terms s th

The Ellison Medical Foundation A NO\rK ' r- ctI-PF'ORATI,:;N

Senior Scholar in Aging Award Browse Awards by Year The Ellison Medical Foundation Senior Scholar in Aging program is designed to support established >r 2011 investigators working at institutions in the U S to conduct research in the basic biological sciences >r 2010 relevant to understanding lifespan development and age-related processes diseases and disabilities 2009 The award is intended to provide significant support to allow the development of novel, innovative » 2008 research programs by investigators who are not currently conducting aging research or who wish to >+ 2007 develop new research programs in aging The Foundation particularly aims to stimulate new research that has rigorous scientific foundations but is not funded adequately, either because of its perceived » 2006 novelty, its high risk, or because it is from an area where traditional research interests absorb most 2005 funding Senior Scholar awards provide funding up to $150,000 per year for a four-year penod » 2004 2003 Specific areas of interest include, but are not limited to » 2002

Structural biology >ti 2001 Molecular genetics ±r 2000 • Studies with model systems ranging from lower eukaryotes to humans 1999 Inquiries testing the relevance of simpler models to human aging 1998 • Genetic epidemiology of aging, candidate longevity genes • Aging in the immune system Host defense molecules in aging systems Mechanisms of free radical induced cell aging Mechanisms of aging in various differentiated cell populations Gene/environment and gene/gene interactions Integrative physiology New approaches to age-modulated disease mechanisms

.v The Ellison Medical l'oundat,on tag E Ridges ills 131, (1. ('hone 301-829-t141o Mont Ain, MD 21771-516o Fat ,fur-819-6413 r 2010 Ellison Medical Foundation

Page 2 of 10 STATEMENT C THE LAWRENCE ELLA FOUNDATION (FKA THE ELLIScEDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2

ABOUT I PROGRAMS I EXPLORE AGING RESEARCH I HOW TO APPLY Entei Search Terns

The Ellison Medical Foundation r^^-j^r-0r1r coy r ;.Ra-i Irv

Senior Scholar in Aging Award - Application Procedures

The Ellison Medical Foundation Senior Scholar program is designed to support established investigators working at institutions in the U S to conduct research in the basic biological and basic biomedical sciences relevant to understanding Itfespan development processes and age-related diseases and disabilities The award is intended to provide significant support to allow the development of new, creative research programs by investigators who may not currently be conducting aging research or who wish to develop new research programs in aging The Foundation particularly seeks to stimulate new research that has rigorous scientific foundations but is currently inadequately funded, either because of ds perceived novelty, high risk, or because it is from an area where other "traditional" research interests absorb most funding

Areas of interest include, but are not limited to

Structural biology Molecular genetics Studies with model systems ranging from lower eukaryotes to humans Inquiries testing the relevance of simpler models to human aging Genetic epidemiology of aging candidate longevity genes Aging in the immune system Host defense molecules in aging systems Mechanisms of free radical induced cell aging Mechanisms of aging in various differentiated cell populations Gene/environment and gene/gene interactions Integrative physiology New approaches to age-modulated disease mechanisms

Overview Senior Scholar awards are for up to $150,000 direct costs per year, plus full indirect costs, for four years and are non-renewable Potential Senior Scholars apply initially by submitting a Letter of Intent Those selected to submit a full application will be notified and provided with necessary application materials and instructions Note : Any Interested researcher may submit a Letter of Intent for the 2013 Senior Scholar in Aging award competition; however , current or past Senior Scholar Awardees are not eligible.

A complete set of Instructions for the 2013 Senior Scholar Letter of Intent will be posted around November 1, 2012

You must complete your Senior Scholar Letter of Intent ONLINE at http /Nvww cybergrants com/emflsentor-scholar-lot Online submissions will be accepted after December 1 2012

Letters of Intent are due by March 7, 2013 (online submissions must be completed by 11 59 p.m. Eastern Standard Time).

Page 3 of 10 STATEMENT C THE LAWRENCE ELLA FOUNDATION (FKA THE ELLISEDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2 Those invited to submit a full application on the basis of their Letter of Intent will be notified of their selection and provided with application instructions by mid-May, 2013 The Senior Scholar full applications will be due in late June, 2013

Senior Scholar awardees will be notified in mid-August, 2013.

The earliest possible start date of the award is dependent on completion of the award agreement with the grantee institution

Eligibility Established investigators employed by US 501(c)(3) institutions, colleges, universities or non- profit research organizations are eligible to apply Any interested researcher may submit a Letter of Intent for the 2013 Senior Scholar in Aging award competition, however, current or past Senior Scholar Awardees are not eligible to apply There is no limit to the number of Senior Scholar letters of intent that may be submitted from any one institution

Evaluation Applicants for the Senior Scholar Award are expected to furnish evidence of substantial prior scientific creativity and productivity, not necessarily targeted to aging research heretofore Evaluation by the Aging Review Group and the Scientific Advisory Board will consider scientific contributions to date, the quality of publications, and the importance of the proposed new research to understanding fundamental aging mechanisms The Aging Review Group and the Scientific Advisory Board will pay close attention to arguments about why the work falls outside the scope of or would not qualify for support from, established funding sources such as the NIA Except for compelling circumstances, the awards are not intended to supplement ongoing, already funded programs but, instead, to inspire new directions that may entail substantial risk Up to 25 Senior Scholar awards will be made in the fall of 2013

Terms of the Award Each award will be made for up to $150,000 per year direct costs plus full indirect costs at the institution's NIH negotiated rate, for up to four years Funding for years two, three and four is contingent upon submission of an acceptable progress report

Acceptable uses for award funds include project-related salaries, other personnel costs equipment, supplies, resource acquisition and travel Carry-overs in excess of $25,000 must be approved by the Foundation Indirect costs are not permitted on equipment, even for purchases less than $5,000

For all (new and non-competing renewal) awards supporting research involving human subjects, animal subjects, research collaborations with foreign institutions, biosafety issues or human embryonic stem cells the Foundation will require the following documentation before an award can be made

1 Human subjects a Copies of the protocol submitted to the Institutional Review Board(s) for this project' and the notification of protocol approval from all relevant IRBs (for funded awards, an annual update will be required at the time of the progress report) b Documentation from the applicant institution that the principal investigator has completed training on the protection of human research participants 2 Animal subjects a A copy of Institutional Animal Care and Use Committee approval for this project (for funded awards , an annual update will be required at the time of the progress report) 3 Foreign component a A letter of support from the collaborating in-country institution , signed by an appropriate official of that institution 4 Biosafety Research supported by The Ellison Medical Foundation is expected to conform to the relevant NIH Guidelines for biosafety, including those for handling of hazardous reagents and those for research involving recombinant DNA and gene transfer (see http //oba od nih gov/rdna/mhgwdelmes_oba htmi)

Page 4 of 10 STATEMENT C THE LAWRENCE ELL A FOUNDATION (FKA THE ELLISO AEDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2 a A copy of Institutional Biosafety Committee approval for this project' Human Embryonic Stem Cell Research Committee approval of the protocol for this project' if it involves human embryonic stem cells

'Approval for this project means the EMF-funded project, not a similar protocol funded by another entity

Address any questions to:

Kevin Lee, Ph D Executive Director Phone 301-829-6410 klee@ellisonfoundation org

The Ellison Medical Foundation

AlonnlAm•,MD2t771-s-6o F ek,iui-8.aq - 641,j Q 2010 Ellison Medical Foundation

Page 5 of 10 STATEMENT C THE LAWRENCE ELLIS FOUNDATION (FKA THE ELLISCAEDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2

ABOUT I PROGRAMS I EXPLORE AGING RESEARCH I HOW TO APPLY :Enter Search Terms s th

_ The Ellison Medical Foundation ANrtiFP.C -ITcrrc,A-i3N

New Scholar Award in Aging Browse Awards by Year New Scholar awards provide support for newly independent investigators beginning in the first 3 years i, 2012 after their postdoctoral training, when they are establishing their own labs and their careers are at a » 2011 vulnerable stage These awards contribute to a safety net that allows bright young scientists to staff » 2010 their laboratories, collect preliminary data, and organize research programs of sufficient momentum to » 2009 obtain ongoing support from other sources New Scholar awards provide funding up to $100,000 per » 2008 year for a four year period >' 2007 New Scholar candidates are investigators who are nominated by U S medical institutions and » 2006 universities for their outstanding promise in aging research Invited institutions may nominate two » 2005 candidates Prospective candidates are encouraged to consult this website for more information about » 2004 the goals and objectives of the Aging Program and eligibility requirements under Application 2003 Procedures Depending upon the number of nominations submitted and the qualifications of the 2002 nominees up to 25 scholars will be selected +i 2001 New Scholar applications are solicited by Invitation only. Invitations for nomination of New 2000 Scholar candidates are sent to eligible institutions annually in the fall (For invited institutions Please » 1999 notify The Ellison Medical Foundation your institution has new president head if a or of sponsored » 1998 research so that the initial letter of invitation will be received by the appropriate Individual) Institutions not currently invited may contact Dr Kevin Lee to discuss an application for inclusion in the program

.6+ the Ellison Medical Foundation tut R Ri gmil• (It'd :'hors ,lot-829.64io NmIntA,t MD21771-526o I-nr 3oi- 829-61IS CQ 2010 Ellison Medical Foundation

Page 6 of 10 STATEMENT C THE LAWRENCE ELLI FOUNDATION (FKA THE ELLISAEDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2

ABOUT PROGRAMS I EXPLORE AGING RESEARCH I HOW TO APPLY Enter Search rerms

ti ^ A4rr, The Ellison Medical Foundation ,-

New Scholar in Aging Award - Application Procedures

The objective of The Ellison Medical Foundation New Scholar in Aging program is to support new investigators of outstanding promise in the basic biological sciences relevant to understanding lifespan development processes and age-related diseases and disabilities The award is intended to provide new faculty with support during the especially critical first three years of their independent research career

New Scholar Applications are solicited by Invitation only. Invitations to nominate candidates for the 2013 application cycle will be sent to the president and to the head of the sponsored research program for invited institutions in October, 2012 The invited institutions may nominate two candidates to apply For invited institutions , Please notify The Ellison Medical Foundation if your institution has a new contact for the nomination process so that the initial letter of invitation will be received by the appropriate individual To discuss institutional eligibility, contact Or Kevin Lee

Areas of interest include, but are not limited to

Structural biology Molecular genetics • Studies with model systems ranging from lower eukaryotes to humans Inquiries testing the relevance of simpler models to human aging Genetic epidemiology of aging Candidate longevity genes Aging in the immune system Host defense molecules in aging systems Mechanisms of free radical induced cell aging Mechanisms of aging in various differentiated cell populations Gene/environment and gene/gene interactions • Integrative physiology New approaches to age-modulated disease mechanisms

Overview New Scholar awards are for up to $100,000 per year, total costs, for a four year period

A complete set of Instructions for the 2013 New Scholar in Aging application will be posted around November 1, 2012

You must complete your New Scholar Application ONLINE at http //www cybergrants com/emf/new_scholar

Beginning in December 2012 nominated candidates will receive an email providing instructions and a password to access the application website

Applications are due by February 28, 2013 ( online submissions must be completed by 11:59 p.m Eastern Standard Time).

Page 7 of 10 STATEMENT C THE LAWRENCE ELLI FOUNDATION (FKA THE ELLISC&EDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2 Reference letters must be received separately by the same deadline and should be sent by direct mail fax, or email to The Ellison Medical Foundation 104 E Ridgeville Blvd Mt Airy, MD 21771 FAX 301-829-6413 email estella©ellisonfoundabon org

The letter must indicate the applicant's name and identify the reference's relationship to the applicant (for example, "Thesis Advisor", 'Scientific Reference")

New Scholar awardees will be notified around late May, 2013

The earliest possible start date of the award is dependent on completion of the award agreement with the grantee institution

Eligibility These awards are intended for investigators who are in the first three (3) years of their research careers following their post-doctoral fellowship experience For the 2013 competition, nominees must hold regular full time appointments (tenure or non-tenure) on the faculty of the sponsoring institution by March 1, 2013 and they must have been in such an appointment, whether at the sponsoring institution or other institution(s), for no more than three years as of July 15 2013, i e the first appointment having been made no earlier than July 15, 2010 Time spent in clinical internships, post-doctoral training, residencies, or in work toward board certification does not count as part of the three-year limit

The Ellison Medical Foundation New Scholars may hold one other career development award from a private source concurrently for up to one year This limitation is with regard to overlap of funding type, even in the absence of scientific overlap Examples of conflicting career development or new faculty awards include, but are not limited to American Cancer Society - Research Scholar American Diabetes Association - Career Development Award or Junior Faculty Award, American Federation for Aging Research - AFAR Research Grant, Arnold & Mary Beckman Foundation - Young Investigator Award, Brookdale Foundation - Brookdale Fellowship, Burroughs Wellcome Fund - Career Awards Medical Scientist, Dana Foundation - Brain & Immuno-Imaging (Conventional or Cellular) Award, Hartford Foundation/Amer Geriatric Society - Jahnigen Career Development Scholar or T F Williams Research Scholar, Hillblom Foundation - Hillblom Start-up Grant, Edward Mallinckrodt Jr Foundation - Research Grant, March of Dimes - Basil O'Connor Starter Scholar Research Award, Pew Charitable Trust - PEW Scholar Award, Rosalind & Arthur Gilbert Foundation/AFAR - New Investigators Award in Alzheimer's disease, Sidney Kimmel Foundation for Cancer Research - Kimmel Scholar Award, and Whitehall Foundation - Grants-in-Aid New Scholar Awards will only be made for the full four-year term If a conflicting award is accepted prior to the New Scholar Award, this must be resolved by either declining The Ellison Medical Foundation award or arranging to terminate the conflicting award within one year

Evaluation Nominees for the New Scholar Award are expected to have great promise as potential leaders of biomedical science with relevance to aging Each nominee's potential for scientific innovation, leadership, and relevance to aging will be evaluated by the Aging New Scholar Review Group and the Scientific Advisory Board, based upon the nominee's research proposal, scientific contributions to date, and the reference statements provided by those who know the nominee and his/her work well The quality and relevance of the nominee's publications and the importance to aging of the nominee's proposed research will be significant factors in the evaluation process Depending upon the number of nominations

Page 8 of 10 STATEMENT C THE LAWRENCE ELLIS FOUNDATION (FKA THE ELLISOOEDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2 submitted and the qualifications of the nominees , up to 25 New Scholars will be selected in 2013

Terms of the Award Each award will be made for up to $100,000 per year, total costs, for a four year period Funding for years two, three, and four is contingent upon submission of an acceptable progress report

Acceptable uses for award funds include project-related salaries, other personnel costs, equipment, supplies, resource acquisition and travel The scholar's salary costs (including fringe benefits) may not exceed $20,000 per year Carry-overs in excess of $25,000 must be approved by the Foundation Not more than 8% of the total award may be deducted for overhead costs -

For all (new and non-competing renewal) awards supporting research involving human subjects, animal subjects, research collaborations with foreign institutions, biosafety issues, or human embryonic stem cells the Foundation will require the following documentation before an award can be made

1 Human subjects a Copies of the protocol submitted to the Institutional Review Board(s) for this project' and the notification of protocol approval from all relevant IRBs (for funded awards, an annual update will be required at the time of the progress report) b Documentation from the applicant institution that the principal investigator has completed training on the protection of human research participants 2 Animal subjects a A copy of Institutional Animal Care and Use Committee approval for this project' (for funded awards, an annual update will be required at the time of the progress report) 3 Foreign component a A letter of support from the collaborating in-country institution, signed by an appropriate official of that institution 4 Biosafety Research supported by The Ellison Medical Foundation is expected to conform to the relevant NIH Guidelines for biosafety, including those for handling of hazardous reagents and those for research involving recombinant DNA and gene transfer (see http //oba od nih gov/rdna/nih_guidelines_oba htmq a A copy of Institutional Biosafety Committee approval for this project' 5 Human Embryonic Stem Cell Research Committee approval of the protocol for this project' if it involves human embryonic stem cells

'Approval for this oroiect means the EMF-funded project, not a similar protocol funded by another entity

Address any questions to:

Kevin Lee, Ph D Executive Director Phone 301-829-6410 klee@ellisonfoundation org

The Ellison Medical Foundation mi 8 Ridgt,,llr iihd Phone 3m-829 6iio MounLAiry NID2i771-;260 Fey 30i-829.6413 r 2010 Ellison Medical Foundation

Page 9 of 10 STATEMENT C THE LAWRENCE ELLIJ FOUNDATION (FKA THE ELLISOEDICAL FOUNDATION) 94-3269827 2012 FORM 990-PF, PART XV, LINE 2

ABOUT I PROGRAMS I EXPLORE AGING RESEARCH I HOW TO APPLY rEnter Search Terms SeZrCh

= The Ellison Medical Foundation =_.44 A N o1,r' t..^.i lT C0PT` 0 RATi:•N

Conference and Workshop Awards - Application Procedures

Support is provided on a competitive basis for conferences and workshops for the dissemination of information relevant to basic biological research toward understanding Idespan development processes and age-related diseases and disabilities The expectation is that this sharing of knowledge will expand the scientific pool of researchers and benefit the scientific community in aging research as a whole

The Foundation accepts applications to support conferences and workshops throughout the year These will be considered by the Scientific Advisory Board at the next scheduled meeting Applications should be received at least 5 months prior to the planned conference or workshop

NOTE ' Conference funding proposals will next be reviewed at the EMF Scientific Advisory Board meeting in December , 2012 To be considered at that time, the proposal must be received by November 15, 2012

EMF support for conferences and workshops is generally in the $2 000 to $10,000 range Applications for conferences or workshops should be brief (about 2 pages), including a description of the meeting objectives, relevance to the Foundation's scientific mission (research on the biological mechanisms underlying aging, lifespan, age-related disease and age-related decline of vitality), meeting dates and venue, total budget, expected participants, requested level of EMF support, a budget Indicating how the EMF funding would be allocated, other expected contributors, and why support is being requested from EMF rather than traditional sources If available, an agenda or speaker list should be attached

EMF requires the designation of specific sessions or speakers for support and this designated support must be acknowledged in the meeting program or other public announcement Proposals must indicate the sessions or speakers to be supported by The Ellison Medical Foundation For conferences, the foundation does not support the travel of students or post-dots unless they will make platform presentations, poster presentations or simple attendance will not be supported Indirect costs for conferences are not allowed

For further information, contact:

Kevin Lee, Ph D Executive Director Phone 301-829-6410 klee@elllsonfoundatlon org

7Trc Ellixon Medical Foundation w4 I_ ILdpe,Jlc I31vJ I'hunr 3ot-829-641o Yount Airy Ail) 2t-rn-6260 Fax (Snr•829-64td Co 2010 Ellison Medical Foundation

Page 10 of 10 STATEMENT C i

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The-a nd'ersfgheci certify that:

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F-Wt0il34%MTIFICATE OP AML't1DMZTh41.UOC I hereby certify the the foregoing transcript of _page(s) • is a full, true and correct copy of the original record in the custody of the Catdomla Secretary ofbe 's office

,( , SEP 0 3 2013 Date:

D^SORA 6OWEN , searetary of State • • OMB No 1545-0172 For,, 4562 Depreciation and Amortization 990-PF Including Information on Listed Property) 2012 Department of the Treasury ( Attachment Internal Revenue Service ( See separate instructions. ► Attach to your tax return. Sequence No 179 Name(s) shown on return Business or activity to which this form relates Identifying number THE LAWRENCE ELLISON FOUNDATION FKA THE ELLISON MEDICAL FOUNDATION) (FORM 990-PF PAGE 1 94-3269827 PSrt I Election To Expense Certain Property Under Section 179 Note : If you have any listed property, complete Part V before you complete Part/ 1 Maximum amount (see instructions) . . _ 1 500,000. 2 Total cost of section 179 property placed in service (see instructions) 2 3 Threshold cost of section 179 property before reduction in limitation 3 2 , 000 , 000. 4 Reduction in limitation. Subtract line 3 from line 2. If zero or less, enter -0- 4

5 Dollar limitation for tax y ear Subtract line 4 from line 1 If zero or less , enter - 0- If married filin g s ep arataltely, see instructions 5 6 (a) Description of property (b) Cost (business use only) (c) Elected cost

7 Listed property. Enter the amount from line 29 1 7 1 8 Total elected cost of section 179 property. Add amounts in column (c), lines 6 and 7 8 9 Tentative deduction. Enter the smaller of line 5 or line 8 10 Carryover of disallowed deduction from line 13 of your 2011 Form 4562 10 11 Business income limitation. Enter the smaller of business income (not less than zero) or line 5 11 12 Section 179 expense deduction. Add lines 9 and 10, but do not enter more than line 11 13 Carryover of disallowed deduction to 2013. Add lines 9 and 10, less line 12 ► 13 Note: Do not use Part II or Part Ill below for listed property. Instead, use Part V. Part II Special Depreciation Allowance and Other Depreciation (Do not include listed property.) 14 Special depreciation allowance for qualified property (other than listed property) placed in service during the tax year . . . 14 15 Property subject to section 168(f)(1) election ...... 16 Other deoreclatlon (includina ACRS) 16 I Fart III I MACRS Depreciation (Do not include listed property.) (See Instructions.) Section A 17 MACRS deductions for assets placed in service in tax years beginning before 2012 17 2,853.

18 If you are electing to group any assets placed in service dunng the tax year into one or more general asset accounts , check here ► ...... ,,,.. ,,. Section B - Assets Placed in Service Durina 2012 Tax Year Usina the General Depreciation System

(b) Month and (c) Basis for depreciation ( businessrnvestment d) Recovery (a) Classification of property year placed ( use period (e) Convention (f) Method (g) Depreciation deduction in service only - see instructions) 19a 3-year property b 5-year property c 7-year property 3,693. 7 YRS. MQ SL 66. d 10-year property e 15-year property f 20-year property 25-year property 25 yrs. S/L 27.5 yrs. MM S/L h Residential rental property / / 27.5 yrs. MM S/L / 39 yrs. MM S/L i Nonresidential real property / MM S/L Section C - Assets Placed in Service During 2012 Tax Year Using the Alternative Depreciation System 20a Class life S/L b 12 ear 12 yrs. S/L c 40 ear / 40 yrs. MM S/L Part N I Summary (See instructions.) 21 Listed property. Enter amount from line 28 21 22 Total. Add amounts from line 12 , lines 14 through 17, lines 19 and 20 in column (g), and line 21. Enter here and on the appropriate lines of your return . Partnerships and S corporations - see instr. 22 .2, 919 . 23 For assets shown above and placed in service during the current year, enter the portion of the basis attributable to section 263A costs 23 12-28-12 LHA For Paperwork Reduction Act Notice, see separate instructions . Form 4562 (2012) 31 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 THE L1ENCE ELLISON FOUNDATION 0 F6rm4562 2012 ( FKA THE ELLISON MEDICAL FOUNDATION ) 94-3269827 Pa e 2 Rant' V Listed Property (Include automobiles , certain other vehicles , certain computers, and property used for entertainment , recreation, or amusement.) Note: For any vehicle for which you are using the standard mileage rate or deducting lease expense, complete only 24a, 24b, columns (a) through (c) of Section A, all of Section B, and Section C if applicable. Section A - Depreciation and Other Information (Caution : See the instructions for limits for passenger automobiles.)

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Date Type of property Business/ Cost or Basis for depreciation Recovery Method/ Depreciation Elected placed in investment rousinessenvest (list vehicles first) other basis period Convention deduction section 179 service use percentage use Dory) cost 25 Special depreciation allowance for qualified listed property placed in service during the tax year and used more than 50% in a qualified business use 25

27 Property used 50% or less in a qualified business use:

I % I I I I S/L - I I

28 Add amounts in column (h), lines 25 through 27. Enter here and on line 21, page 1 128

Section B - Information on Use of Vehicles Complete this section for vehicles used by a sole proprietor, partner, or other 'more than 5% owner," or related person. If you provided vehicles to your employees, first answer the questions in Section C to see if you meet an exception to completing this section for those vehicles.

(a) (b) (c) (CO (e) (f) 30 Total business/investment miles driven during the Vehicle Vehicle Vehicle Vehicle Vehicle Vehicle year (do not include commuting miles) 31 Total commuting miles driven during the year 32 Total other personal (noncommuting) miles driven 33 Total miles driven during the year. Add lines 30 through 32 34 Was the vehicle available for personal use Yes No Yes No Yes No Yes No Yes No Yes No during off-duty hours? 35 Was the vehicle used primarily by a more than 5% owner or related person? 36 Is another vehicle available for personal use? Section C - Questions for Employers Who Provide Vehicles for Use by Their Employees Answer these questions to determine if you meet an exception to completing Section B for vehicles used by employees who are not more than 5% owners or related persons. 37 Do you maintain a written policy statement that prohibits all personal use of vehicles, including commuting, by your Yes No employees? . . 38 Do you maintain a written policy statement that prohibits personal use of vehicles, except commuting, by your employees? See the instructions for vehicles used by corporate officers, directors, or 1 % or more owners 39 Do you treat all use of vehicles by employees as personal use's 40 Do you provide more than five vehicles to your employees, obtain information from your employees about the use of the vehicles, and retain the information received? . 41 Do you meet the requirements concerning qualified automobile demonstration use? _ Note: If your answer to 37, 38, 39, 40, or 41 is "Yes, " do not complete Section B for the covered vehicles part #I Amortization (a) (b) (c) (d) (e) (1) Description of costs Daeamorbzabon Amortizable code fmortiabon Amortization b ins amount section period or im=M to for this year 42 Amortization of costs that begins during your 2012 tax year:

43 Amortization of costs that began before your 2012 tax year 43 44 Total. Add amounts in column (f). See the instructions for where to report 44

216252 12-28-12 Form 4562 (2012) 32 14251031 731920 9827 2012.04030 THE LAWRENCE ELLISON FOUNDA 9827 1 Form 8868 Appli ion for Extension of Time To le an (Rev. January 2013) Exempt Organization Return;i OMB No. 1545.1709 Department of the Treasury Internal Revenue Service 1111i File a separate application for each return.

• If you are filing for an Automatic 3-Month Extension , complete only Part I and check this box ► ^X • If you are filing for an Additional (Not Automatic) 3-Month Extension , complete only Part 11 (on page 2 of this form). Do not complete Part // unless you have already been granted an automatic 3-month extension on a previously filed Form 8868. Electronic filing (e-file) You can electronically file Form 8868 if you need a 3-month automatic extension of time to file (6 months for a corporation required to file Form 990-T), or an additional (not automatic) 3-month extension of time. You can electronically file Form 8868 to request an extension of time to file any of the forms listed in Part I or Part II with the exception of Form 8870, Information Return for Transfers Associated With Certain Personal Benefit Contracts, which must be sent to the IRS in paper format (see instructions). For more details on the electronic filing of this form, visit www.frs. ov/ef le and click on a-file for Chanties & Nonprofits Part 1 Automatic 3-Month Extension of Time. Only submit original (no copies needed). A corporation required to file Form 990-T and requesting an automatic 6-month extension - check this box and complete Part I only Po. All other corporations (Including 1120-C filers), partnerships, REMICs, and trusts must use Form 7004 to request an extension of time to file Income tax returns. Type or Name of exempt organization or other filer, see instructions. Employer identification number (EIN) or print THE ELLISON MEDICAL FOUNDATION 94-3269827 File by the due date for Number, street , and room or suite no. If a P.O. box, see instructions . Social security number (SSN) filing your C/O 101 YGNACIO VALLEY ROAD, NO. 310 return See instructions City, town or post office , state, and ZIP code . For a foreign address, see instructions. WALNUT CREEK, CA 94596

Enter the Return code for the return that this application is for (file a separate application for each return) 0 4

Application Return Application Return Is For Code Is For Code Form 990 or Form 990-EZ 01 Form 990-T (corporation ) 07 Form 990-BL 02 Form 1041-A 08 Form 4720 (individual) 03 Form 4720 09 Form 990-PF 04 Form 5227 10 Form 990-T (sec. 401 a or 408 (a) trust) 05 Form 6069 11 Form 990-T (trust other than above) 06 Form 8870 12 PHILIP B. SIMON - C/O 101 YGNACIO VALLEY RD #320, WALNUT • The books are in the care of 10- CREEK, CA - 94596 977-9060 (925) 977-9064 Telephone (925) FAX No. ► • If the organization does not have an office or place of business in the United States , check this box ► 0 • If this is for a Group Return , enter the organization 's four digit Group Exemption Number (GEN) . If this is for the whole group , check this box ► 0 . If it is for part of the group , check this box 0, 0 and attach a list with the names and EINs of all members the extension is for 1 I request an automatic 3-month (6 months for a corporation required to file Form 990-T) extension of time until AUGUST 15, 2 0 1 3 ' , to file the exempt organization return for the organization named above . The extension is for the organization 's return for: 01 LX calendar year 2 O 12 or 0. tax year beginning , and ending

2 If the tax year entered in line 1 is for less than 12 months , check reason : Initial return Final return 0 Change in accounting penod

3a If this application is for Form 990 - BL, 990- PF, 990-T, 4720, or 6069 , enter the tentative tax, less any nonrefundable credits . See instructions . 3a $ 458,028. b If this application is for Form 990- PF, 990-T, 4720, or 6069 , enter any refundable credits and estimated tax payments made . Include an y nor year overpayment allowed as a credit 3b $ 919,933. c Balance due. Subtract line 3b from line 3a. Include your payment with this form , if required, by usin g EFTPS (Electronic Federal Tax Payment System) . See instructions. 3c 0 Caution . If you are going to make an electronic fund withdrawal with this Form 8868 , see Form 8453 - EO and Form 8879 - EO for payment instructions. LHA For Privacy Act and Paperwork Reduction Act Notice , see instructions. Form 8868 (Rev. 1.2013)

223841 01-21-13 1-201 If you are filing for an Additional (Not Audhatic) 3-Month Extension , complete only Part 11 and nceck this box ► Note. Only complete Part II if you have already been granted an automatic 3-month extension on a previously filed Form 8868. • If you are filing for an Automatic 3-Month Extension , complete only Part I (on page 1). 1Part II Additional (Not Automatic) 3-Month Extension of Time. Only file the original (no copies needed). Enter filer 's identifying number , see instructions Type or Name of exempt organization or other filer, see instructions Employer identification number (EIN) or print Filebythe HE ELLISON MEDICAL FOUNDATION , 94-326982 7 due date for Number, street, and room or suite If P.O filing your no. a . box, see instructions. Social security number (SSN) return see /0 101 YGNACIO VALLEY ROAD, NO. 310 instructions City, town or post office , state , and ZIP code. For a foreign address , see instructions. ALNUT CREEK, CA 9 4 596

Enter the Return code for the return that this application is for (file a separate application for each return) ED]

Application Return Application Return Is For Code Is For Code Form 990 or Form 990-EZ 01 Form 990-BL 02 Form 1041-A - 08 Form 4720 (individual) 03 Form 4720 09 Form 990-PF 04 Form 5227 10 Form 990-T (sec. 401 a or 408 (a) trust) 05 Form 6069 11 Form 990-T (trust other than above) 06 Form 8870 12 STOP! Do not complete Part II if you were not already granted an automatic 3-month extension on a previousl y filed Form 8868. PHILIP B. SIMON - C/O 101 YGNACIO VALLEY RD #320, WALNUT CREEK, CA - 4 5 6 • The books are in the care of ► 9 9 (925) 977-9060 925 TelephoneNo.'- FAXNo. ► 977-9064 • If the organization does not have an office or place of business in the United States, check this box ► Ei • If this is for a Group Return , enter the organization 's four digit Group Exemption Number (GEN) If this is for the whole group , check this box ► If it is for part of the group , check this box ► and attach a list with the names and EINs of all members the extension is for. 4 I request an additional 3-month extension of time until NOVEMBER 15, 2013 . 5 For calendar year 2 012 , or other tax year beginning , and ending 6 If the tax year entered in line 5 is for less than 12 months, check reason : Initial return Final return Change in accounting period 7 State in detail why you need the extension ADDITIONAL INFORMATION FROM THIRD PARTY SOURCES NECESSARY TO THE PREPARATION OF THE RETURN IS STILL PENDING; THEREFORE, ADDITIONAL TIME TO FILE IS REQUIRED.

8a If this application is for Form 990-BL, 990-PF, 990-T, 4720, or 6069, enter the tentative tax, less any nonrefundable credits. See instructions. $ 458,028. b If this application is for Form 990 -PF, 990 -T, 4720, or 6069 , enter any refundable credits and estimated tax payments made . Include any pnor year overpayment allowed as a credit and any amount paid with Form 8868. $ 919,933. c Balance due . Subtract line 8b from line 8a. Include your payment with this form, if required, by using EFTPS (Electronic Federal Tax Payment System . See Inst ructions. $ 0. re and Verification must be completed for Part li only. Under penalties f perjury, I declare that I hay mined this form, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, corrend^co`mp^lete, a that I am nn7nrf to nranara thic fnrm A REPRESENTATIVE Date V Signature ► ► 15 (Rev. 1.2013)

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