Repair of Endogenous Dna Damage

WITH THE COLLABORATION OF: September 24 th -28 th 2017 University of Udine, Italy

UNIVERSIT À DEGLI STUDI DI TRIESTE 6 T H E U - U S

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G 6 EU-US CONFERENCE ON E REPAIR OF ENDOGENOUS DNA DAMAGE The uniqueness of this series of meetings is its focus on the cellular responses to naturally formed genomic damage, and the relationship of defects in these responses to genetically inherited disor - ders associated with cancer predisposition, neuro - logical deficits and premature aging. Understanding the contributions of endogenous DNA damage to human disease, in particular cancer, and the patho - logical changes associated with aging is indeed the major theme of this conference. Recently, there has been an explosion-like increase of information on cancer genomes; the develop - ment of novel technologies for genome editing; vi - sualizing DNA repair complexes; the role for RNA in genome stability; novel mechanisms of DNA re - pair and epigenetics; and the role of aging and en - vironmental exposures in genome stability. A major goal of this meeting is to foster collaborative re - search on the cellular processes that affect ge - nomic instability in cancer. The role of endogenous DNA damage, in particular oxidative DNA damage, as a driver of normal and accelerated aging and the study of premature aging syndromes remain impor - tant areas of interest. Insights from rare inherited human diseases with defects in the DNA damage response continue to illuminate links between en - dogenous DNA damage and cancer, aging and neurologic disease. To promote the translation of knowledge about the sources and repair of endogenous DNA lesions into interventions that improve global human health, this meeting will stimulate collaborative translational re - search focused on the identification of new thera - peutic targets and the development of treatment strategies that either regulate DNA repair pathways in order to enhance cancer treatment, delay neu - rodegeneration, or reduce the pathological changes associated with aging. A key objective of the 2017 meeting is to provide an environment for both early career and senior in - Organization vestigators of diverse backgrounds to communi - cate their latest results on relevant scientific topics and establish interactions that will not only strengthen the numerous basic science and trans - lational research efforts in this arena, but also en - hance the development of the next generation of researchers.

Thanks to the presence of about 40 invited speak - Organizing Committee Private sponsors: Local Organization Committee Official email address: ers, the conference welcomes about 300 partici - Robert W. Sobol (USA), Eugenia Dr. Maria Cristina Scientific and Logistic Program: [email protected] Dogliotti (Italy), Alexander Bürkle Novelli-Quadrifoglio Prof. Gianluca Tell pants from all over the world: scholars, researchers, (GER) and Gianluca Tell (ITA) are Mr Sergio Bertossi [email protected] the Conference Organizers . +39.0432.494311 Acknowledgments doctors, graduate students, technologists. About The Local Conference Dr. Paolo Ermano We acknowledge all the people 130 students from Universities of Udine and Trieste Organizers are as follows: Sponsor Companies: [email protected] who, to different extents, Gianluca Tell (University of Mettler Toledo +39.328.1912722 contributed to the realization of Udine), Claudio Brancolini the Conference. will participate in the meeting and about 170 inter - (University of Udine), Gianni Del Biomolecules Prof. Angelo Vianello [email protected] Institutional representatives : Sal (University of Trieste), Stefan Genomic Vision national delegates will attend. Therefore, this meet - Schoeftner (University of Trieste) +39.0432.558781 Stefano Balloch, Sergio Bolzonello, Marina Brollo, Silvio Brusaferro, ing will create an environment where young and Paolo Ermano (University of Prof. Francesco Nazzi Alessandro Cavarape, Paolo Udine). Local Sponsor Companies: [email protected] Ceccon, Alberto Felice De Toni, +39.0432.558513 scholars and scientific experts from different fields National and I nternational AMGA, Udine Massimo Di Silverio, Andrea institutions that have joined the Prof. Claudio Brancolini Garlatti, Furio Honsell, Vincenzo share the latest results on these important research committee to support the Dorigo [email protected] Martines, Cristiano Shaurli, organization of this prestigious D’AnnataWines +39.0432.494382 Bruno Stefanon, Edi Turco, conference through logistics, Alessandro Venanzi. topics, and establish relationships that will not only Arbea Dr. Silvano Piazza persons or economic support are: [email protected] University of Udine (Italy) AUTONORD FIORETTO strengthen research efforts on this scientific field, +39.0461.314440 Personnel from the University University of Trieste (Italy) but can positively influence the growth of a new Book of Abstracts of Udine : Luca Bazzichetto, School of Advanced Studies, Scholarships for Students Stefano Bonomi, Silvia Burra, Trieste (SISSA) and Post-Docs Dr. Giulia Antoniali Erika Codarin, Marta Codrich, generation of scientists. [email protected] Plinio De Zorzi, Silvia Lolini, Istituto Superiore di Sanità (Roma) We planned a total of 12 +39.0432.494313 Giovanna Mangiapane, Patrizia scholarships for students and University of South Alabama (USA) Dr. Matilde Clarissa Malfatti Nacci, Anna Paulet, Renato postdoctoral fellows. These Spoletti. In the 2017 edition, as a special guest, Tomas Lin - University of Konstanz (DE) scholarships will be handed out [email protected] AREA Science Park, Trieste in the form of reimbursement for +39.0432.494313 Students of the School of Biotechnology from the dahl, the 2015 Nobel Laureate in Chemistry, will Friuli Innovazione (Udine) travel expenses and registration Dr. Marco De Anna discounts for Congress [email protected] University of Udine : Gabriele present the Opening Lecture. He has substantially Consorzio per la Biomedicina participation. The funds will be +39.0432.556273 Coluccino, Annachiara Crosato, Molecolare, CBM, Trieste used primarily to offset the cost De Tchadjet Olive, Alice Della contributed to the discovery of the mechanisms of National Institutes of Health, of travel and registration for 6 Administrative Marina, Francesca De Vecchi, NIH (USA) fellows from the United States and Secretary Office: Alessandro Fornasaro, Berenice repair of DNA damage caused by reactive oxygen and 6 fellows from Europe Furlan, Alice Gaiatto, Martina Associazione Italiana selected by the Organizing Dr. Nila Colledani Giacomini, Kokallaj Mirela, species that are involved in many human diseases per la Ricerca sul Cancro (AIRC) Committee, from the submitted [email protected] Martina Lisa, Sofia Mastroianni, Piano Lauree Scientifiche - MIUR abstracts, based on the quality +39.0432.494300 Lara Minisini, Manuela Orlandi, including aging. Fondazione Fegato of the presented work. Dr. Giacomo Meula Stefano Pezzella, Anita Pitassi, giacomo.meula@friuliforma - Ilaria Rosso, Arianna Sandron, Fondazione Friuli Funds for scholarship are Anna Sbalchiero, Francesca sponsored by Dr. Maria Cristina zione.it Promoturismo FVG +39.0432.276402 Sbuelz, Damiano Tosolini, Novelli-Quadrifoglio and Dr Cristina Totis. Comune di Udine Sergio Bertossi in the memory of +393498174128 Comune di Cividale Prof. Franco Quadrifoglio for his Mrs. Marina Dorligh Photographers : Giancarlo Cro unforgettable contribution to the [email protected] and Sofia Tell. Fondazione De’ Claricini development and dissemination +39.0432.49494202 Aeronautica Militare Italiana of Molecular Biology at the University of Udine. Dr. Valentina Molignoni The Organizing Commitee also Bachelor School of Biotecnologies [email protected] wishes to thanks: and Master School in Molecular Scholarships are also funded in +39.0432.494905 Biotechnologies, University of Udine part by Associazione Italiana per Simone Bordon, Maria Serena la Ricerca sul Cancro (A.I.R.C.). Mrs. Marilena Migliorati Bruno, Roberto Vicario. Postgraduate School of Geriatrics, [email protected] University of Udine +39.0432.494303 PhD in Biomedical Sciences Mrs. Manuela Tomad and Biotechnologies, [email protected] University of Udine +39.0432.494301

2|6TH EU-US CONFERENCE ON REPAIR OF ENDOGENOUS DNA DAMAGE, UDINE (ITALY) 6TH EU-US CONFERENCE ON REPAIR OF ENDOGENOUS DNA DAMAGE, UDINE (ITALY) | 3 UniVErSitY of UdinE paLaZZo antonini Location

The University projects at the national and international it offers all those opportunities typical of level. The present number of students en - bigger centers: traditional “osterie” (eater - The meeting is held at the University of rolled at the University is approx. 17000. ies), pubs, wine bars, cafes, restaurants, Udine (http://www.uniud.it). pizzerias, theaters, cinemas, discos, mu - Udine and its University are a point of ref - This venue was chosen because it offers seums, and shopping malls among the erence in a region which is historically a unique informal interactive environment biggest in Europe. known as a meeting place and the cross - in the charming City of Udine, in the Re - roads of different worlds and cultures. Ge - A relaxing walk through the city centre gion called Friuli Venezia Giulia in the ographically situated in the centre of the brings the visitor to the Museo Diocesano North East region of Italy, in the centre of European Union, the University of Udine where one can appreciate the beauty of Europe, close to Venice and Slovenia. The plays an active role in a close network of Giambattista Tiepolo frescos and, cross - Area has been recognized as one of the relations, committed to sharing its knowl - ing one of the most beautiful venetian best destinations in the World from the edge and ideas. Since its establishment, squares on terra firma (“Piazza Libertà”), Lonely Planet – Best in Travel 2016 Udine University has pursued the policy of to reach, in a refined context, a great vari - agency (http://www.turismofvg.it/). Udine internationalisation, aimed at preparing ety of coffee bars, pastry shops, wine- is a city at the centre of Europe that has students and forging relations and part - tasting shops, pizzerias and restaurants. been chosen because it can offer a unique nerships with universities and institutions Over the past several years, Udine has atmosphere to develop collaborations. In - in Europe and the rest of the world. deed, the city will allow optimal interaction been host to several special national and between participants, ensuring different Udine University collaborates not only international events: U din&Jazz , refined moments of inspiring collaborations be - within Europe but across the globe and and interesting jazz festival with interna - tween American and European scientists. has long-standing connections with Africa, tional artists; V icino/Lontano and the pre - In addition, in the city several promotional India and China. mio Tiziano Terzani , which involves the events of this congress have been orga - world of international literature, for a de - nized in order to diffuse knowledge and bate on contemporaneity topics. The Far awareness on the topics discussed. The City East Film Festival is another important big Udine (https://www.visit-udine.it/en/) is a event, hugely acknowledged and appreci - The University of Udine was founded in ated in its gender. Friuli Doc is the well- 1978 as part of the reconstruction plan of small city of 100,000 inhabitants; it has a bourgeois and refined heart, surrounded by renowned as a wine-culinary regional Friuli after the earthquake in 1976. Its aim kermesse that calls thousands of atten - was to provide the Friulian community typical small and dynamic rural villages whose architectures testify their rural origin. dees. In the last years Udine hosted great with an independent centre for advanced pop and rock music shows with Madonna, training in cultural and scientific studies. Udine is worldwide recognized for the Coldplay, Bruce Springsteen, U2, Bon The University currently has the following number of its bookshops and this aspect Jovi, Pink Floyd etc.. unveils the nature of this people, also re - degree programmes: Agriculture, Biotech - The theatrical movement is very lovely and nologies, Economics, Engineering, Law, freshing the ancient pleasure of being the third city, after Milan and London, to pro - active with the main theatre Giovanni da Modern Languages, Communication and Udine characterized of a traditional pro - Training, Humanities, Medicine and vide public lighting installations in the early 20 th century. gramme, and the more experimental Surgery and Mathematics, Computer Sci - Teatro Contatto , particularly dedicated to ence and Multimedia. In line with the times, Udine claims an ex - young people and students. The University is actively involved in stu - cellent optical fibre net that guarantees an dent and staff exchange projects with uni - ultraspeed internet connection. The Territory versities within the EU and is currently Udine is highly appreciated for its quality engaged in close collaboration with sev - of life, it has a good bike sharing service Friuli Venezia Giulia, small land situated at eral universities from Eastern Europe and which allows one to reach numerous sites the north-east of Italy, in the middle of the other non-EU countries. Moreover, the such as theaters, cinemas, museums and European landscape, in the past stage of University participates in many research the several University branches. Moreover, wars and incessant changes of borders UdinE Loggia dEL LionELLo

4|6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 5 Law and EConomiCS CampUS between Italy, Slovenia and Austria, in heavily stroken by an earthquake, and The Miramare Castle stands on the peak ConfErEnCE room these days shows its treasures: completely demolished by another in of a rock in the Gulf of Trieste. It was built 1976. Rebuilt “ as it was and where it was ” by Archduke Ferdinand Maximilian of In the land of floodings (south of Friuli) in has in the dome the symbol of “ earthquake Hapsburg in the mid-nineteenth century 186 B.C. Aquileia was born as a military and rebirth ”. Nowadays all the city is hon - as a residence for himself and his wife, settlement, the second latina estabilished oured as Italian national monument and Charlotte of Belgium. From the castle, you by the roman empire to protect it from the this year elected the most beautiful village can enjoy a magnificent view of the Gulf invasions of the Gauls. It was the east in Italy ( borgo dei borghi 2017 ). of Trieste and in its rooms you can admire gate of the empire Unesco heritage from many of the original furnishings. The cas - 1998, had a past of richness due to pros - A colony built by the Romans on the hills tle is surrounded by a lush park consisting perous trade, facilitated by water paths with an urban implant of “ cardo e de - of hundreds of exotic plants. and a tremendous river harbor near the cumano ” Cividale del Friuli became Un - sea. Roman Aquileia, Christian Aquileia, in esco heritage in 2011. Favorite location of medieval age was elected the second the langobardic dukedom, later became Venues for the inaugural capital city after Milan, and nowadays the abode of the aquileians patriarchs. Be - and the scientific sessions continues to disclose a fascinating history cause of the heavy destructions suffered disclosed and written with the large con - during the second World War, Cividale The inaugural session will be held at the tribution by the University of Udine with took the honor with the silver military Teatro Giovanni da Udine , which is the archeological digs and laboratories. Once medal. Nowadays Cividale shows itself as main Theatre of the City with the presence upon a time, it was second only to Rome a small pearl around the green Natisone of the main Local Political and Institutional in matter of political influences, being for river; in the middle ages it was the capital representatives ( www.teatroudine.it/) . all the medieval era the biggest diocese in city of the region with the name Forum The meeting sessions will be held in the Europe. In the cathedral, we can find a Julii , giving later the name of the entire re - Economic Pole building that can accom - kaleidoscope of transformations occurred gion Friuli. During the franks dominion it modate up to 430 people classroom style during the centuries; behind the cathedral became Civita Aaustriae , city of the south - and has adjacent space that will be used we may find the cemetery where were ern region of the reign, where Udine was to serve coffee and light refreshments dur - buried the first soldiers died in the Carso named “ la terra grande ”. ing breaks and for display of the posters area during the first World War; later one Udine , protected by the alps, with the (goo.gl/maps/QtBTKNzbuWt). of those had been buried in the symbolic open spaces of the friulian plain and, to - monumental grave of the Milite Ignoto at This arrangement will permit increased wards south, the lagoon and the sea; “ terra the Vittoriano in Rome. visibility of the posters, which will foster grande”, dominated by the aquileian patri - further interactions between the younger The ample friulian plain inspired a group archate first, then homeland of Friuli under and more senior investigators attending of Venetian notables the realization of an the venetian dominion, is the center of the the meeting. AV equipment and support idea: in 1593, during the Venetian domin - ideal geographic compass which allows will be provided by the University of ion, born the perfect fortress for a strong the visitor to reach the borders of a varied Udine. All places have free high-speed in - defense from the Turkish invasions. Its region in the range of one hour (from the ternet access. Meals designated in the name was Palma. Its nine-head-star mountains to the sea), a land defined in the Program will be served in the nearby cafe - shape had been one of the most demand - nineteenth century by the poet Ippolito teria, onsite. Vegetarian alternatives will be ing enterprises in Venice history, symbol Nievo “ the summary of the Universe”. available at all meals. of strength and wisdom of the republic. Trieste (www.turismofvg.it/Localita/Trieste) The perimetral wall, strengthened by is a Roman city approximately from 50 b. Napoleon Bonaparte who renamed the C. In it are conserved the ruins of the Foro city Palmanova ( Unesco heritage in and the Theater. After being repeatedly 2017), remained to defend a military com - raided during the barbarian invasions and pound which had never been involved in following the Frankish domination, the city, any battle. Perfectly synthesizing the joint at the beginning of the XI century, began of both civil and military architectures, it to revive. In 1382 the development of Tri - won the most important challenge against este is restricted by the Republic of Venice, the madness of nazists, whose projects which ruled the Adriatic Sea. Hence, the were to completely destroy it. town decides embrace the Hapsburg influ - Nestled at the feet of the giulian alps, Ven - ence. Under Maria Teresa of Austria’s reign zone , the only “stone” of 4 th century in all (XVII century) the city establishes itself as the region, splendid example of architec - an important commercial port, by taking tonic and artistic refurbishment. Venzone the urban appearance that one can admire was the staging post towards the north today. In 1918 Trieste becomes a part of along the roman via Julia Augusta , rich and Italy, but after the Second World War, it is flourishing city during the Aquileian Patri - once more limited, this time by the Iron archate, so much to enforce itself with Curtain. Trieste, by being a city on the bor - walls, castles and the moat, unfortunately der, has become an important multicultural suffered several invasions before the year and multi-religious centre, which takes 1000. It had been dominated by Napoleon pride in its prominent university centre and Bonaparte first, then by Austrians, in 1866 cultural environment whilst searching for entered in the Italian Reign. In 1348 was its role in today’s Europe. Law and EConomiCS ConfErEnCE bUiLding

6|6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 7 SUndaY mondaY 12:40-13.00 SEptEmbEr 24, 2017 SEptEmbEr 25, 2017 Speakers chosen from submitted program tEatro aULa 3, Law and abstracts gioVanni da UdinE EConomiCS CampUS 12:40 Nima Mosammaparast The ASCC complex mediates 15:00-17:00 8:30-10:40 a ubiquitin-dependent signaling Registration SESSION 1 - REPLICATION STRESS axis specific for ALKBH-mediated 17:00-17:50 8:30 demethylation repair Welcome Alexander Bürkle - Session Chair 12:50 17:00-17:15 8:40 Alex Pines Gianluca Tell Hocine Mankouri TRIC chaperonin control transcription Welcome and Introductory Remarks Analysis of replication-associated after UV damage by regulating Cockayne 17:15-17:45 mutagenesis at a single stalled replication fork Syndrome protein A Institutional Welcomes 9:10 13:00-14:30 Prof. Alberto Felice De Toni Dana Branzei LUNCH – provided at the Cafeteria Rector of the University of Udine Molecular studies of DDX11/Chl1 of ‘ Renati Campus ’ Other Institution Welcome Addresses helicase implicated in the Warsaw breakage syndrome 17:45-19:00 14:30-16:30 Opening Plenary/Keynote Lecture 9:40 SESSION 3 - REGULATORY Matthias Dobbelstein 17:45-18:00 MECHANISMS OF RNA FUNCTIONS p53 and checkpoint signaling as IN GENOME STABILITY Eugenia Dogliotti determinants of DNA replication stress Opening Keynote Introduction 14:30 10:10 Gianluca Tell - Session Chair 18:00-19.00 Alessandro Vindigni Tomas Lindahl New mechanisms of replication stress 14:40 Nobel Prize for Chemistry 2015 response to cancer chemotherapeutics Martin A.M. Reijns Enzymatic surveillance Genome-embedded ribonucleotides 10:40-11:00 the good, the bad and the ugly of DNA instability Coffee Break 15:10 19:30-22:00 Francesca Storici Buffet (sponsored by the Organizers) 11:00-13:00 DNA repair by template RNA for the Invited speakers SESSION 2 - DNA EDITING: and paying Registrants 15:40 MECHANISMS UNDERLYING Fabrizio D’Adda di Fagagna MUTATIONAL SIGNATURES The role of non-coding RNA in the DNA IN HUMAN CANCERS damage response Spouse Program 11:00 16:10 (Optional and fee-paying Robert W. Sobol - Session Chair Hilde Nilsen with limited availability): 11:10 Implication of SMUG1 RNA processing 11:30-12:30 Ludmil Alexandrov activity for telomere maintenance Guided visits to historical Udine Signatures of mutational processes 16:30-17:00 in human cancer Coffee Break 11:40 17:00-19:00 David H. Wilson III Poster Session Repair mechanisms for endogenous DNA damage 19:00 DINNER - on your own 12:10 (different choices will be proposed) Samuel H. Wilson Modulating the DNA polymerase reaction equilibrium through chemical biology Spouse Program (Optional and fee-paying with limited availability): 11:30 or 17:45 Guided visits to historical Udine

6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 9 tUESdaY 12:40 wEdnESdaY 11:40 thUrSdaY 12:40-13.00 SEptEmbEr 26, 2017 Boris Pfander SEptEmbEr 27, 2017 Haico Van Attikum SEptEmbEr 28, 2017 Speakers chosen from submitted aULa 3, Law and Chromatin constitutes a bottleneck in the aULa 3, Law and Regulation and dynamics of DNA repair in aULa 3, Law and abstracts EConomiCS CampUS response to double strand breaks EConomiCS CampUS a chromatin context EConomiCS CampUS 12:40 13:10-14:30 12:10 Jeo Seok Han LUNCH – provided at the Cafeteria of Conchita Vens Control of DNA damage response and 8:30-10:30 ‘Renati Campus ’ 8:30-10:30 Towards radiotherapy and PARP inhibitor 8:30-10:30 DNA repair by small molecules SESSION 4 - NON-CANONICAL SESSION 7 - ADVANCED SESSION 9 - DEFECTS IN THE DNA combination: mechanism and clinical 12:50 ACTION AND NOVEL REGULATORS TECHNOLOGIES FOR ANALYSIS aspects DAMAGE RESPONSE AS TARGETS OF DNA REPAIR 14:30-16:30 OF DNA REPAIR AND FOR PERSONALIZED THERAPEUTIC Rajendra Prasad THE DNA DAMAGE RESPONSE APPROACHES DNA polymerase : The missing link of the 8:30 SESSION 6 - STABILITY β Eugenia Dogliotti - Session Chair OF THE GENOME IN AGING 12:40-13.00 base excision repair machinery in 8:30 8:30 mammalian mitochondria 8:40 AND NON-NEOPLASTIC DISEASE Alan Tomkinson - Session Chair Speakers chosen from submitted Robert W. Sobol - Session Chair abstracts 13:00-14:30 Patrick Sung 14:30 8:40 8:40 Novel role of the BRCA1-BARD1 Eugenia Dogliotti - Session Chair 12:40 LUNCH – provided at the Cafeteria of Elisa Ferrando-May Trey Ideker ‘Renati Campus ’ complex in RAD51-mediated 14:40 Optical control and real-time imaging Muralidhar Hegde Mapping the DNA damage response homologous recombination Björn Schumacher of DNA damage and repair New Mechanism of Genome damage and hierarchy by analysis of systematic genetic 14:30-16:00 9:10 Non-cell-autonomous regulation of the Repair defects in motor neuron disease: networks Closing Plenary 9:10 Role of TDP-43 John Tainer DNA damage response Michele Morgante 9:10 14:30 Flap endonuclease 1 employs DNA 15:10 NGS-based technologies for studying 12:50 Chris Bakkenist Robert W. Sobol sculpting and phosphate steering to genome stability and structural diversity Sathya Balachander ATR kinase inhibitors attenuate radiation- Closing Keynote Introduction ensure specific 5´-flap incision Tohru Minamino A critical role of cellular senescence in Ribose-seq upgraded: a robust technique induced T cell exhaustion and potentiate T 14:40 to prevent genome instability 9:40 to map ribonucleotides incorporated in any metabolic and cardiovascular disease Bret D. Freudenthal cell activity in the tumor microenvironment Phil Hanawalt 9:40 genomic DNA From Repair Replication to R-loops in half- Alan Tomkinson 15:40 APE1 cleavage mechanisms 9:40 Vilhelm Bohr during DNA repair 13:00-14:00 Randi Gussgard Syljuåsen a-century Targeting mitochondrial DNA repair LUNCH – provided at the Cafeteria of in cancer cells DNA damage, neurodegeneration and Mechanisms and consequences of basal 15:40 mitochondrial dysfunction ‘Renati Campus ’ ATR/Chk1 activity in human cells Public announcement of the names 10:10 10:10-10.30 14:00-18:30 of the Travel Fellowships awardees Jean-Marc Egly 16:10 Speakers chosen from submitted 10:10 Pier Giorgio Mastroberardino Guided visits to downtown Udine and to Nina Gustafsson for best Poster Presentation Cockayne syndrome A and B proteins abstracts the UNESCO World Heritage Site Cividale regulate transcription arrest through a DNA damage and repair in chronic Protecting the genome through metabolic 16:00 neurodegeneration 10:10 18:30 enzymes Gianluca Tell ubiquitin/proteasome degradation process Altaf Wani 16:40-17:00 Dinner partially sponsored by the 10:40-11:00 Closing Remarks 10:40-11:00 Regulation of post-repair restoration Organizers Coffee Break Coffee Break of epigenetic chromatin mark Coffee Break Silvio Brusaferro Location: Villa DeClaricini (Director of the Department of Medicine, 17:00-19:00 10:20 (http://www.declaricini.it/) Poster Session University of Udine): 11:00-13:00 Olga Lavrik 11:00-13:00 Thank you and Farewell SESSION 5 - DNA DAMAGE, 19:00 Protein-protein interactions SESSION 10 – CELL TYPE AND DNA EPIGENETICS AND DNA REPAIR DINNER - on your own operating in base excision DNA repair DAMAGE SPECIFICITY IN DNA REPAIR 11:00 (different choices will be proposed) 10:30-11:00 11:00 Spouse Program (Optional David H. Wilson III - Session Chair Coffee Break Eugenia Dogliotti - Session Chair and fee-paying with limited availability): 11:10 Spouse Program (Optional 11:10 11:30 or 17:45 Guided visits to historical Udine Roderick J. O’Sullivan and fee-paying with limited availability): 11:00-13:00 Leona Samson Interrogating the mechanism 9:00-16:00 SESSION 8 - POLY(ADP-RIBOSYL)ATION Cell specific responses to alkylation and of Alternative Lengthening of Telomeres Visit to the Roman city of Aquileia IN THE DNA DAMAGE RESPONSE: inflammation 11:40 (Basilica, Roman ruins and the exposition PRE-CLINICAL AND TRANSLATIONAL 11:40 Gaëlle Legube “Faces from Palmira”) and to the ASPECTS Bruce Demple Chromosome and chromatin dynamics “Miramare Castle” in Trieste 11:00 Crosslinks produced during attempted during DNA double strand break repair To be confirmed Alexander Bürkle - Session Chair DNA repair 12:10 11:30 or 17:45 11:10 12:10 Primo Schär Guided visits to historical Udine Françoise Dantzer Bernd Kaina DNA repair mediated DNA demethylation Poly(ADP-ribose) polymerase 3 (PARP3) in DNA repair and death regulation in human generates site-directed chromatin myeloid immune cells plasticity genome integrity and beyond

10 | 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 11 alexandrov Ludmil ideker trey Sobol w. robert [email protected] [email protected] [email protected] USA Los Alamos National Laboratory USA UC San Diego USA University of South Alabama Mitchell LiSt Cancer Institute bakkenist Chris kaina bernd ‘[email protected] ’ [email protected] Storici francesca USA University of Pittsburgh GERMANY University Medical Center [email protected] USA Georgia Institute of Technology of SpEakErS bohr Vilhelm Legube gaëlle [email protected] [email protected] Sung patrick USA National Institutes of Health FRANCE University of Toulouse [email protected] USA Yale University branzei dana Lindahl tomas [email protected] [email protected] Syljuåsen gussgard randi ITALY The FIRC Institute of Molecular UK The Francis Crick Institute [email protected] Oncology Foundation NORWAY Oslo University Hospital mankouri hocine bürkle alexander [email protected] tainer John [email protected] DENMARK University of Copenhagen [email protected] GERMANY University of Konstanz USA The University of Texas MD Anderson mastroberardino pier giorgio Cancer Center d’adda di fagagna fabrizio [email protected] [email protected] THE NETHERLANDS Erasmus University tell gianluca ITALY The FIRC Institute of Molecular Medical Center [email protected] Oncology Foundation ITALY University of Udine minamino tohru dantzer françoise [email protected] tomkinson alan [email protected] JAPAN Niigata University Graduate School [email protected] FRANCE Strasbourg University of Medical and Dental Sciences USA University of New Mexico demple bruce morgante michele Van attikum haico [email protected] [email protected] [email protected] USA Stony Brook University Medical School ITALY University of Udine THE NETHERLANDS Leiden University Medical Center dobbelstein matthias nilsen hilde [email protected] [email protected] Vens Conchita GERMANY University Medical Center NORWAY University of Oslo [email protected] Göttingen THE NETHERLAND The Netherlands Cancer o’sullivan J. roderick Institute dogliotti Eugenia [email protected] [email protected] USA University of Pittsburgh Vindigni alessandro ITALY Istituto Superiore di Sanità Roma [email protected] pfander boris USA Saint Louis University School of Egly Jean-marc [email protected] Medicine [email protected] GERMANY Max Planck Institute of FRANCE Institut de Génétique et de Biologie Biochemistry wilson h. david iii Moléculaire et Cellulaire [email protected] reijns a. m. martin USA National Institute on Aging, IRP, NIH ferrando-may Elisa [email protected] [email protected] UK The University of Edinburgh wilson h. Samuel GERMANY Bioimaging Center of Konstanz [email protected] Samson d. Leona USA National Institutes of Health freudenthal d. bret [email protected] [email protected] USA Massachusetts Institute of Technology USA University of Kansas Medical Center Schär primo gustafsson nina [email protected] [email protected] SWITZERLAND University of Basel SWEDEN Karolinska Institute Schumacher björn hanawalt philip [email protected] [email protected] GERMANY University of Cologne USA Stanford University

12 | 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 13 akbari mansour baptiste beverly burger kaspar Dr Dr PostDoc University of Copenhagen, DENMARK National Institute of Environmental Health University of Oxford, UNITED KINGDOM LiSt of [email protected] Sciences, USA [email protected] P69 [email protected] P15 albelazi mustafa burra Silvia PhD bazlekowa-karaban milena PhD dELEgatES University of Salford, UNITED KINGDOM PhD University of Udine, ITALY [email protected] University of Warsaw, POLAND [email protected] P34 [email protected] P41 P39 alexeeva marina Caglayan melike PhD bazzani Veronica PhD University of Stavanger, NORWAY PhD National Institute of Environmental Health [email protected] Sissa, ITALY Sciences, USA P35 [email protected] [email protected] P79 P42 ali reem PhD berardinelli francesco Campalans anna University of Nottingham, UNITED KING - Dr Researcher DOM University Roma Tre, ITALY Commissariat à l’énergie atomique et aux [email protected] [email protected] énergies alternatives, FRANCE P8 [email protected] P72 allocca mariacarmela bjelland Svein PhD PhD Carvalho dias gustavo Massachusetts Institute of Technology, University of Stavanger, NORWAY PhD USA [email protected] Universidad Autónoma de Madrid, SPAIN [email protected] [email protected] P19 P2 blanco Luis alnajjar khadijeh Prof Cisneros g. andrés PhD Centro de Biologia Molecular Severo PhD Yale University, USA Ochoa, SPAIN University of North Texas, USA [email protected] [email protected] [email protected] P36 P2 P67 alsøe Lene bolognesi Claudia Codrich marta PhD Dr PostDoc University of Oslo, NORWAY Unità di Cancerogenesi Ambientale Dept University of Udine, ITALY [email protected] Epidemiologia Clinica, ITALY [email protected] P37 [email protected] antoccia antonio Coluzzi Elisa Ass. Prof. borsuk Ewelina maria PhD University Roma Tre, ITALY PhD Università degli studi Roma Tre, ITALY [email protected] Institute of Biochemistry and Biophysics [email protected] PAS, POLAND [email protected] antoniali giulia P1 Cukrov dubravka PostDoc PhD University of Udine, ITALY bosio maria Cristina University of Pisa, ITALY [email protected] Dr [email protected] P20 Università degli studi di Milano, ITALY P70 [email protected] balachander Sathya P21 Curtin nicola PhD Prof Georgia Institute of Technology ,USA bosshard Sandra Newcastle University, UNITED KINGDOM [email protected] PhD [email protected] P38 University of Lausanne, SWITZERLAND P88 [email protected] P40

6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 15 Czerwinska Jolanta Esbensen Qin Ying ishchenko alexander kurmasheva raushan maffia antonio mosammaparast nima PhD PhD Dr PhD PhD PhD Institute of Biochemistry and Biophysics University of Oslo, NORWAY UMR 8200 CNRS Paris Saclay, FRANCE The University of Texas Health Science Università degli Studi di Pavia, ITALY Washington University, USA PAS, POLAND [email protected] [email protected] Center, USA [email protected] [email protected] [email protected] [email protected] P54 P27 P44 ferino annalisa Jaruga pawel malacaria Eva muoio daniela d’alessio barbara PhD Dr Landi Stefano PhD PhD Master University of Udine, ITALY National Institute of Standards and Tech - Prof University La Sapienza, ITALY Università degli studi Roma Tre, ITALY University of Pisa, ITALY [email protected] nology, USA University of Pisa, ITALY [email protected] [email protected] [email protected] P47 [email protected] [email protected] P4 P3 P90 fortini paola malfatti matilde Clarissa muzi-falconi marco daley James Dr Jemth ann-Sofie Laurila niina PhD Prof PhD ISTITUTO SUPERIORE DI SANITA’, ITALY PhD PhD University of Udine, ITALY University of Milano, ITALY Yale University School of Medicine, USA [email protected] Translational Medicine and Chemical Biol - University of Oulu, FINLAND [email protected] [email protected] [email protected] P48 ogy, SWEDEN [email protected] P85 P64 P45 [email protected] P53 gervai Judit Zsuzsanna mangiapane giovanna orioli donata de rosa mariarosaria MSc Lavrik olga PhD Dr PhD Hungarian Academy of Sciences, HUN - karwowski boleslaw Prof University of Udine, ITALY IGM- CNR, ITALY University Federico II of Naples, ITALY GARY Prof Institute of Chemical Biology and Funda - [email protected] [email protected] [email protected] [email protected] Meical University of Lodz, POLAND mental Medicine, RUSSIA P76 [email protected] [email protected] P51 P11/P78 marcon francesca oksenych Valentyn dellino gaetano ivan ghahe Somayeh Shahmoradi Dr PhD PhD PhD kassahun henok Lee Jong-Soo ISTITUTO SUPERIORE DI SANITA’, ITALY Institute of Cancer Research and Molecular European Institute of Oncology, ITALY University of Warsaw, POLAND PhD PhD [email protected] Medicine, NORWAY [email protected] [email protected] Akershus univeristy hospital, NORWAY Ajou University, KOREA P48 [email protected] P74 P9 [email protected] [email protected] P57 P91 martin peter di masi alessandra götz alexandra PhD park Suhyung Ass. Prof. PhD kohoutek Jií Lee kyoo-young University of Salford, UNITED KINGDOM Dr Roma Tre University, ITALY University of Oslo, NORWAY PhD Dr [email protected] Institute for Basic Science, SOUTH KROEA [email protected] [email protected] Veterinary Research Institute, CZECH RE - Institute for Basic Science, SOUTH KOREA P92 [email protected] P16 PUBLIC [email protected] P6 [email protected] P22 menin Luca diatlova Evgeniya han Joo Seok P86 PhD parlanti Eleonora Master Dr Licata nausicaa Valentina University of Milano-Bicocca, ITALY Dr Novosibirsk State University, RUSSIA Institute for Basic Science, SOUTH KOREA kopená olga PhD [email protected] ISTITUTO SUPERIORE DI SANITA’, ITALY [email protected] [email protected] Research worker University of Trento, ITALY P5 [email protected] P33 P82 Institute of Biophysics of the CAS, CZECH [email protected] REPUBLIC miggiano riccardo dizdaroglu miral harris reuben [email protected] PostDoc pascucci barbara PhD PhD P84 Lirussi Lisa Università degli Studi del Piemonte Orien - Dr National Institute of Standards and Tech - Howard Hughes Medical Institute, USA Dr tale, ITALY Area della Ricerca Roma 1, ITALY nology, USA [email protected] kosicki konrad University of Oslo, NORWAY [email protected] [email protected] [email protected] P10 Dr [email protected] P56 P58 P43 / P50 Polish Academy of Sciences, POLAND P25 hedge mUraLidhar [email protected] milanese Chiara pennisi rosa dzimková marta Ass. Prof P83 Loffredo rosa PostDoc PhD PhD Houston Methodist Research Institute and PhD Erasmus Medical Center, THE NETHER - Università degli studi Roma Tre, ITALY Masaryk University, CZECH REPUBLIC Cornell University, USA kroustallaki penelope University of Trento, ITALY LANDS [email protected] [email protected] [email protected] PhD [email protected] [email protected] P59 P81 P71 University of Olso, NORWAY P26 [email protected] peripolli Silvia Elder rhoderick inga alberto P24 Longo antonella mognato maddalena PhD PhD Dr PhD PhD University College London, UNITED KING - University of Salford, UNITED KINGDOM University of Trento, ITALY kumari bhavini Università degli studi Roma Tre, ITALY University of Padova, ITALY DOM [email protected] [email protected] PhD [email protected] [email protected] [email protected] INDIAN INSTITUTE OF TECHNOLOGY P80 PATNA, INDIA [email protected] P52

16 | 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 17 peterson Lisa rissech Joan frigola Serebrenik artur Villa matteo PhD PhD PhD PhD University of Minnesota, USA Institute for research in biomedicine (IRB University of Minnesota, USA Università di Milano Bicocca, ITALY [email protected] Barcelona) [email protected] [email protected] P93 [email protected] P12 P7 pezone antonio Silvestrov pavel wagner J. richard PhD rossi franca MS PhD University Federico II of Naples, ITALY Researcher University of North Texas, USA Université de Sherbooke, CANADA [email protected] University of Piemonte Orientale, ITALY [email protected] [email protected] P60 [email protected] P75 P55/P62 P56 pines alex Stevnsner tinna walker alice Dr rundle Stuart PhD PhD Erasmus Medical Center, THE NETHER - MD Aarhus University, DENMARK University of North Texas, USA LANDS Newcastle University, UNITED KINGDOM [email protected] [email protected] [email protected] [email protected] P49 P89 P28 P88 tesfahun almaz nigatu wani altaf prasad rajendra russo antonella PhD PhD Dr Prof University of Stavanger, NORWAY The Ohio State University, USA National Institute of Environmental Health University of Padova, ITALY [email protected] [email protected] Sciences, USA [email protected] P66 P65 [email protected] P3 P94 thatte Jayashree wennerström anna rzeszutek iwona PhD Mrs prosperi Ennio PhD International Centre for Genetic Engineering Akershus University Hospital, NORWAY Dr University of Bern, SWITZERLAND and Biotechology, ITALY [email protected] Consiglio Nazionale delle Ricerche, ITALY [email protected] [email protected] [email protected] P18 P29 P31 You panpan Santorsola mariangela theil arjan PhD radhakrishnan Sabarinathan Dr PhD University of Oslo, NORWAY PhD University of Trieste, ITALY Erasmus Medical Center, THE NETHER - [email protected] Institute for Research in Biomedicine (IRB [email protected] LANDS Barcelona), SPAIN [email protected] [email protected] P30 Zabolotnaya Ekaterina Saparbaev murat PhD PhD tuppurainen hanna University of Cambridge, UNITED KING - radicella J.pablo Gustave Roussy Cancer Campus, FRANCE PhD DOM Dr [email protected] University of Oulu, FINLAND [email protected] Institute of Cellular and Molecular Radiobi - P23 [email protected] P77 ology, FRANCE P13 [email protected] Scalera Claudia Zappone antonina P46 Dr turturro Sabrina Dr IGM- CNR, ITALY PhD Sissa, ITALY rawat Vipin [email protected] Università degli studi Roma Tre, ITALY [email protected] PhD P73 [email protected] P17 International Centre for Genetic Engineering and Biotechology, ITALY Schaich matt Zarkovic gabriella [email protected] PhD Venier paola PhD P61 University of Kansas Medical Center, USA Prof University Paris-Saclay, FRANCE [email protected] Università degli Studi di Padova, ITALY [email protected] recagni marta P63 [email protected] P32 Dr Fondazione IRCCS Istituto Nazionale dei Schillaci odessa Zharkov dmitry Tumori, ITALY Dr Vieru andra-Stefania Dr [email protected] University of Trieste, ITALY PhD Institute of Molecular and Cellular Biology, P87 [email protected] Charles University, CZECH REPUBLIC RUSSIA [email protected] [email protected] P14 P68

18 | 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 19 Abadi Zahra Jamali Rasht Bressan Chiara Curtolo Erica University of Udine, Italy University of Udine, Italy University of Trieste, Italy LiSt of fVg [email protected] [email protected] [email protected] Albanesi Enrico Bucca Sebastian Cutano Valentina University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] StUdEntS Alfarè Lovo Matteo Buemi Valentina De Iasi Cristina University of Udine, Italy Sissa, Italy University of Udine, Italy [email protected] [email protected] [email protected] Antonini Marialuisa Busellato Ilaria De Luca Lorenzo Alvio University of Udine, Italy University of Udine, Italy University of Udine, Italy partiCipantS [email protected] [email protected] [email protected] Argenti Carlotta Buzzelli Alice De Marco Simone University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Armellin Riccardo Caiazzo Giorgia De Rosa Valeria University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Armenise Doriana Calligaris Matteo De Stefani Adele University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Ayyildiz Dilara Camerer Sophia Diana Maria De Vecchi Francesca University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Bacchetti Giacomo Candotto Giulia Del Mestre Pierfrancesco University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Bagolin Margherita Cela Ilaria Della Marina Alice University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Baschino Samantha Ciol Lorenzo Di Centa Laura University of Trieste, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Bertoli Andrea Ciotti Sonia Drusin Andrea University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Bettini Paolo Coluccino Gabriele Duca Giacomo University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Bier Francesca Copetti Paolo Ecca Fabrizio University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Bigo Angelica Croatto Martina Fagotto Valentina University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] Bortolus Gloria Crosato Annachiara Foffano Lorenzo University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected]

20 | 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 21 Fornasaro Alessandro Lemonche Gerard Boix Montanari Tommaso Pregnolato Grazia Vergolini Ettore University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] [email protected] Fortuna Nicolò Lera Cristina Moratti Massimo Racanelli Dominga Vuerli Martika University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] [email protected] Franforte Elisa Liberi Matteo Olivo Lia Radecka Dorota Zambon Alberto University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] [email protected] Furlan Berenice Lise Veronica Orlandi Manuela Ragazzon Elisa Zanon Alice University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] [email protected] Furlan Michela Londero Chiara Orlani Alice Rodaro Chiara Zappone Antonina University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy Sissa, Italy [email protected] [email protected] [email protected] [email protected] [email protected] Gaiatto Alice Marano Lorenzo Paluvai Harikrishnareddy Rosso Ilaria Zilio Chiara University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] [email protected] Giacomini Martina Marini Lorenzo Papa Nicole Sandron Arianna Zonta Laura University of Udine, Italy University of Udine, Italy University of Trieste, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] [email protected] Godeas Grazia Martin Asia Amelia Pavan Eleonora Sbalchiero Anna University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] Goi Jessica Martina Lisa Perosa Gianluca Sbuelz Francesca University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] Guerrini Benedetta Maso Stefano Pezzella Stefano Scandino Riccardo University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] Iacobucci Lorenzo Mastroianni Sofia Pipetone Francesca Maria Antonietta Tenani Giorgia University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] Ianna Giulia Minisini Lara Piscopo Giuseppe Tomba Giovanni University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] Iovine Michela Minisini Martina Pitassi Anita Toscani Cristoforo University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] Kocina Chandra Giorgia Molinari Chiara Plosch Daniele Tosolini Damiano University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] Lanza Umberto Mondello Alessia Plozner Noemi Totis Cristina University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected] Lavaroni Jacopo Montanar Valentina Polo Friz Erika Trevisanut Matteo University of Udine, Italy University of Udine, Italy University of Udine, Italy University of Udine, Italy [email protected] [email protected] [email protected] [email protected]

22 | 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) 6th EU-US ConfErEnCE on rEpair of EndogEnoUS dna damagE, UdinE (itaLY) | 23 ORGANIZATION COMMITTEE

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