Dissecting Scalp Folliculitis a 25-Year Old African
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Rapid Development of Perifolliculitis Following Mesotherapy
CASE LETTER Rapid Development of Perifolliculitis Following Mesotherapy Weihuang Vivian Ning, MD; Sameer Bashey, MD; Gene H. Kim, MD patient received mesotherapy with an unknown substance PRACTICE POINTS for cosmetic rejuvenation; the rash was localized only to the injection sites.copy She did not note any fever, chills, • Mesotherapy—the delivery of vitamins, chemicals, and plant extracts directly into the dermis via nausea, vomiting, diarrhea, headache, arthralgia, or upper injections—is a common procedure performed respiratory tract symptoms. She further denied starting in both medical and nonmedical settings for any new medications, herbal products, or topical therapies cosmetic rejuvenation. apart from the procedure she had received 2 weeks prior. • Complications can occur from mesotherapy treatment. Thenot patient was found to be in no acute distress and • Patients should be advised to seek medical care with vital signs were stable. Laboratory testing was remarkable US Food and Drug Administration–approved cosmetic for elevations in alanine aminotransferase (62 U/L [refer- techniques and substances only. ence range, 10–40 U/L]) and aspartate aminotransferase (72 U/L [reference range 10–30 U/L]). Moreover, she had Doan absolute neutrophil count of 0.5×103 cells/µL (refer- ence range 1.8–8.0×103 cells/µL). An electrolyte panel, To the Editor: creatinine level, and urinalysis were normal. Physical Mesotherapy, also known as intradermotherapy, is a examination revealed numerous 4- to 5-mm erythematous cosmetic procedure in which multiple -
Hair Loss in Infancy
SCIENCE CITATIONINDEXINDEXED MEDICUS INDEX BY (MEDLINE) EXPANDED (ISI) OFFICIAL JOURNAL OF THE SOCIETÀ ITALIANA DI DERMATOLOGIA MEDICA, CHIRURGICA, ESTETICA E DELLE MALATTIE SESSUALMENTE TRASMESSE (SIDeMaST) VOLUME 149 - No. 1 - FEBRUARY 2014 Anno: 2014 Lavoro: 4731-MD Mese: Febraury titolo breve: Hair loss in infancy Volume: 149 primo autore: MORENO-ROMERO No: 1 pagine: 55-78 Rivista: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA Cod Rivista: G ITAL DERMATOL VENEREOL G ITAL DERMATOL VENEREOL 2014;149:55-78 Hair loss in infancy J. A. MORENO-ROMERO 1, R. GRIMALT 2 Hair diseases represent a signifcant portion of cases seen 1Department of Dermatology by pediatric dermatologists although hair has always been Hospital General de Catalunya, Barcelona, Spain a secondary aspect in pediatricians and dermatologists 2Universitat de Barcelona training, on the erroneous basis that there is not much in- Universitat Internacional de Catalunya, Barcelona, Spain formation extractable from it. Dermatologists are in the enviable situation of being able to study many disorders with simple diagnostic techniques. The hair is easily ac- cessible to examination but, paradoxically, this approach is often disregarded by non-dermatologist. This paper has Embryology and normal hair development been written on the purpose of trying to serve in the diag- nostic process of daily practice, and trying to help, for ex- ample, to distinguish between certain acquired and some The full complement of hair follicles is present genetically determined hair diseases. We will focus on all at birth and no new hair follicles develop thereafter. the data that can be obtained from our patients’ hair and Each follicle is capable of producing three different try to help on using the messages given by hair for each types of hair: lanugo, vellus and terminal. -
Expert-Level Diagnosis of Nonpigmented Skin Cancer by Combined Convolutional Neural Networks
Supplementary Online Content Tschandl P, Rosendahl C, Akay BN, et al. Expert-level diagnosis of nonpigmented skin cancer by combined convolutional neural networks. JAMA Dermatol. Published online November 28, 2018. doi:10.1001/jamadermatol.2018.4378 eFigure. Sensitivities (Blue) and Specificities (Orange) at Different Threshold Cutoffs (Green) of the Combined Classifier Evaluated on the Validation Set eAppendix. Neural Network Training eTable 1. Complete List of Diagnoses and Their Frequencies Within the Test-Set eTable 2. Education of Users According to Their Experience Group eTable 3. Percent of Correct Prediction of the Malignancy Status for Specific Diagnoses of a CNN Using Either Close-up or Dermatoscopic Images This supplementary material has been provided by the authors to give readers additional information about their work. © 2018 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/25/2021 eFigure. Sensitivities (Blue) and Specificities (Orange) at Different Threshold Cutoffs (Green) of the Combined Classifier Evaluated on the Validation Set A threshold cut at 0.2 (black) is found for a minimum of 51.3% specificity. © 2018 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/25/2021 eAppendix. Neural Network Training We compared multiple architecture and training hyperparameter combinations in a grid-search fashion, and used only the single best performing network for dermoscopic and close-up images, based on validation accuracy, for further analyses. We trained four different CNN architectures (InceptionResNetV2, InceptionV3, Xception, ResNet50) and used model definitions and ImageNet pretrained weights as available in the Tensorflow (version 1.3.0)/ Keras (version 2.0.8) frameworks. -
Ntvdv Maart 2018, Nummer 3
COLOFON INHOUD Het Nederlands Tijdschrift voor Dermatologie en Venereologie is het officiële orgaan van de Nederlandse Vereniging voor Dermatologie en Venereologie en verschijnt 10x per jaar in een oplage van 1.200 exemplaren. Het NTvDV is vanaf 1 januari 2008 geïndexeerd in EMBase, de internationale wetenschappelijke database van Elsevier Science. NVDV NASCHOLING DERMATOLOGENDAGEN HOOFDREDACTIE Dr. W.P. Arnold, hoofdredacteur 3 Programma Ziekenhuis Gelderse Vallei, afdeling Dermatologie W. Brandtlaan 10 | 6716 RP Ede ARTIKELEN Telefoon 0318-435007 E-mail: [email protected] 5 Behandeling female pattern hair loss ARTIKELEN 8 Non-scarring alopecia Dr. R.C. Beljaards, dr. C.J.W. van Ginkel LEERZAME ZIEKTEGESCHIEDENISSEN 10 Cicatriciële alopecie Dr. R. van Doorn, dr. S. van Ruth, dr. J. Toonstra, dr. T.M. Le ALLERGEEN VAN DE MAAND 15 Trichoscopie Prof. dr. T. Rustemeyer DERMATOCHIRURGIE 19 Geriatrische dermato-oncologie Dr. R.I.F. van der Waal DERMATOLOGIE DIGITAAL 24 Ingenolmebutaat bij actinische keratosen DERMATOLOGIE IN BEELD 25 Beeldtechnologie ondersteunt de arts Dr. R.I.F. van der Waal, dr. A.J. Onderdijk DERMATOPATHOLOGIE 29 Dermatofyten in revisie P.K. Dikrama DERMATOSCOPIE 33 Diagnostiek in de dermatologie Dr. N.A. Kukutsch GESCHIEDENIS VAN DE DERMATOLOGIE 38 Infecties van de neonaat Dr. J. Toonstra, A. Glastra ONDERZOEK VAN EIGEN BODEM 40 Herpes zoster Dr. H.J. Bovenschen, J.C.J. Hellenbrand-Hendriks 42 Chemopreventie van huidkanker PRAKTIJKVOERING Dr. C. Vrijman 46 Mohschirurgie in Nederland: afspraken REFERATEN D.J.C. Komen, dr. M.B.A. van Doorn 48 Plaveiselcelcarcinoom in het hoofd-halsgebied RICHTLIJNEN Dr. J.J.E. van Everdingen 50 Systeemtherapie voor melanoom DERMATOLOGIE IN DE KUNST Dr. -
Copyrighted Material
1 Index Note: Page numbers in italics refer to figures, those in bold refer to tables and boxes. References are to pages within chapters, thus 58.10 is page 10 of Chapter 58. A definition 87.2 congenital ichthyoses 65.38–9 differential diagnosis 90.62 A fibres 85.1, 85.2 dermatomyositis association 88.21 discoid lupus erythematosus occupational 90.56–9 α-adrenoceptor agonists 106.8 differential diagnosis 87.5 treatment 89.41 chemical origin 130.10–12 abacavir disease course 87.5 hand eczema treatment 39.18 clinical features 90.58 drug eruptions 31.18 drug-induced 87.4 hidradenitis suppurativa management definition 90.56 HLA allele association 12.5 endocrine disorder skin signs 149.10, 92.10 differential diagnosis 90.57 hypersensitivity 119.6 149.11 keratitis–ichthyosis–deafness syndrome epidemiology 90.58 pharmacological hypersensitivity 31.10– epidemiology 87.3 treatment 65.32 investigations 90.58–9 11 familial 87.4 keratoacanthoma treatment 142.36 management 90.59 ABCA12 gene mutations 65.7 familial partial lipodystrophy neutral lipid storage disease with papular elastorrhexis differential ABCC6 gene mutations 72.27, 72.30 association 74.2 ichthyosis treatment 65.33 diagnosis 96.30 ABCC11 gene mutations 94.16 generalized 87.4 pityriasis rubra pilaris treatment 36.5, penile 111.19 abdominal wall, lymphoedema 105.20–1 genital 111.27 36.6 photodynamic therapy 22.7 ABHD5 gene mutations 65.32 HIV infection 31.12 psoriasis pomade 90.17 abrasions, sports injuries 123.16 investigations 87.5 generalized pustular 35.37 prepubertal 90.59–64 Abrikossoff -
A Very Rare Case of Dissecting Cellulitis of the Scalp in an Indonesian Man
A Very Rare Case of Dissecting Cellulitis of the Scalp in an Indonesian Man Rizky Lendl Prayogo1, Lusiana1, Sri Linuwih Menaldi1, Sondang P. Sirait1, Eliza Miranda1 1Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia / Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia Keywords: dissecting cellulitis of the scalp, dissecting folliculitis, follicular occlusion tetrad, diagnosis, isotretinoin Abstract: Dissecting cellulitis of the scalp (DCS), also known as dissecting folliculitis, perifolliculitis capitis abscedens et suffodiens (PCAS), or Hoffman’s disease, is a primary neutrophilic cicatricial alopecia without clear etiology. Along with hidradenitis suppurativa, acne conglobata, and pilonidal cyst, they were recognized as ‘follicular occlusion tetrad’. A 43-year-old Indonesian man presented to our department with four years history of persistent, slightly painful subcutaneous nodules, abscesses, and sinuses that discharged purulent exudate on vertex and occipital scalp. There was also associated patchy alopecia. He had severe acne during his adolescence to early adulthood. Trichoscopic evaluation showed yellowish and whitish area lacking of follicular openings. Histopathological examination showed follicular occlusion, dilatation, and rupture with mixed inflammatory infiltrates, mainly neutrophils. The diagnosis of DCS was confirmed by clinical, trichoscopic, and histopathological examinations. Isotretinoin 20 mg daily was given to normalize the follicular keratinization. Considering its very rare occurrence in an Indonesia man, this case was reported to emphasize the diagnosis of DCS. 1 INTRODUCTION should be considered (Otberg & Shapiro, 2012; Scheinfeld, 2014). Considering its low prevalence in DCS, also known as dissecting folliculitis, PCAS, Indonesia, we are intrigued to report a case or Hoffmann’s disease, is a very rare primary emphasizing the diagnosis of DCS. -
New Approach in Combined Therapy of Perifolliculitis Capitis Abscedens Et Suffodiens
726 Letters to the Editor New Approach in Combined Therapy of Perifolliculitis Capitis Abscedens et Suffodiens Felix Jacobs, Gisela Metzler, Jakub Kubiak, Martin Röcken and Martin Schaller Department of Dermatology, Eberhard Karls University, DE-72076 Tuebingen, Germany. E-mail: [email protected] Accepted March 14, 2011. Perifolliculitis capitis abscedens et suffodiens (PCAS) tract. In the upper dermis there was a suppurative inflam- is a rare scalp disease seen mostly in young males of mation with abscess material and hair shaft fragments being discharged via a draining sinus. Periodic acid-Schiff (PAS) Afro-American descent. The disease is characterized by staining for fungi, as well as immunohistochemical staining perifollicular pustules, suppurative nodules and fluctua- with anti-Mycobacterium bovis (BCG) and for T. pallidum was ting abscesses, as well as by intercommunicating sinus negative. Direct immunofluorescence of the perilesional scalp tracts on the scalp. We report here an elderly Caucasian skin was negative. woman who fulfilled the clinical and histological criteria Microbiological examinations failed to identify pathogenic organisms. for diagnosis of PCAS. Following the diagnosis of a PCAS, the patient was treated The patient was treated with initial prednisolone, with 10 mg acitretin and 30 mg prednisolone daily as an inpa- systemic acitretin, topical tacrolimus and oral zinc. tient. The prednisolone was reduced to 5 mg per day during the After 6 months, her condition was stable. course of treatment. Because of the decreased level of zinc, 100 mg zinc aspartate was given daily. In addition, topical gluco- corticoids and tacrolimus 0.1% were alternated. CASE REPOrt This regimen produced almost total healing within 11 days (Fig. -
H a W a I I D E R M P a T H Conference
THE TM HAWAII DERMPATH CONFERENCE MAUI, HI 25.0 CME AMA PRA Category 1 Credits™ 25.0 SAM Credits (Approved provider) MEETING PROGRAM THURSDAY DERMATOPATHOLOGY Alopecia DR BETH RUBEN 1/25/2019 Mighty Women of Dermatopathology Hawaii 2019 Alopecia: Diagnosis via pattern analysis Beth S. Ruben, MD Professor of Dermatology/Dermatopathology University of California, San Francisco Director of Dermatopathology, Palo Alto Medical Foundation 1 Objectives Review basic hair anatomy Hair follicle anatomy Sizes of hair and organization Phases of the hair cycle Explore methods used to prepare sections for diagnosis of alopecia Employ pattern analysis in alopecia Discuss common and emerging examples of non-scarring and scarring alopecia 2 Basic hair anatomy 3 1 1/25/2019 Insert Whiting scan Whiting, 2004 4 Infundibulum SD Isthmus AP Lower follicle 5 6 2 1/25/2019 7 Lower follicle Hair root 8 Matrix Hair papilla 9 3 1/25/2019 10 11 Outer root Cortex sheath Inner Cuticle of Henley inner root root sheath Huxley sheath Cuticle of hair shaft Fibrous sheath 12 4 1/25/2019 Keratinization of hair shaft (Adamson’s fringe) Keratinization of inner root sheath (Huxley) 13 14 15 5 1/25/2019 Sizes of hair and organization 16 Vellus hair Thin, short and hypopigmented hairs Extend within the upper dermis The inner root sheath is as thick or thicker than its hair shaft less than 0.03 mm in diameter 17 Terminal hair Long, thick hair Extends into the subcutis in the scalp Hair shaft greater than 0.06 mm in diameter Normal T:V ratio: at least 2:1 (some say -
Differential Diagnosis of the Scalp Hair Folliculitis
Acta Clin Croat 2011; 50:395-402 Review DIFFERENTIAL DIAGNOSIS OF THE SCALP HAIR FOLLICULITIS Liborija Lugović-Mihić1, Freja Barišić2, Vedrana Bulat1, Marija Buljan1, Mirna Šitum1, Lada Bradić1 and Josip Mihić3 1University Department of Dermatovenereology, 2University Department of Ophthalmology, Sestre milosrdnice University Hospital Center, Zagreb; 3Department of Neurosurgery, Dr Josip Benčević General Hospital, Slavonski Brod, Croatia SUMMARY – Scalp hair folliculitis is a relatively common condition in dermatological practice and a major diagnostic and therapeutic challenge due to the lack of exact guidelines. Generally, inflammatory diseases of the pilosebaceous follicle of the scalp most often manifest as folliculitis. There are numerous infective agents that may cause folliculitis, including bacteria, viruses and fungi, as well as many noninfective causes. Several noninfectious diseases may present as scalp hair folli- culitis, such as folliculitis decalvans capillitii, perifolliculitis capitis abscendens et suffodiens, erosive pustular dermatitis, lichen planopilaris, eosinophilic pustular folliculitis, etc. The classification of folliculitis is both confusing and controversial. There are many different forms of folliculitis and se- veral classifications. According to the considerable variability of histologic findings, there are three groups of folliculitis: infectious folliculitis, noninfectious folliculitis and perifolliculitis. The diagno- sis of folliculitis occasionally requires histologic confirmation and cannot be based -
A Deep Learning System for Differential Diagnosis of Skin Diseases
A deep learning system for differential diagnosis of skin diseases 1 1 1 1 1 1,2 † Yuan Liu , Ayush Jain , Clara Eng , David H. Way , Kang Lee , Peggy Bui , Kimberly Kanada , ‡ 1 1 1 Guilherme de Oliveira Marinho , Jessica Gallegos , Sara Gabriele , Vishakha Gupta , Nalini 1,3,§ 1 4 1 1 Singh , Vivek Natarajan , Rainer Hofmann-Wellenhof , Greg S. Corrado , Lily H. Peng , Dale 1 1 † 1, 1, 1, R. Webster , Dennis Ai , Susan Huang , Yun Liu * , R. Carter Dunn * *, David Coz * * Affiliations: 1 G oogle Health, Palo Alto, CA, USA 2 U niversity of California, San Francisco, CA, USA 3 M assachusetts Institute of Technology, Cambridge, MA, USA 4 M edical University of Graz, Graz, Austria † W ork done at Google Health via Advanced Clinical. ‡ W ork done at Google Health via Adecco Staffing. § W ork done at Google Health. *Corresponding author: [email protected] **These authors contributed equally to this work. Abstract Skin and subcutaneous conditions affect an estimated 1.9 billion people at any given time and remain the fourth leading cause of non-fatal disease burden worldwide. Access to dermatology care is limited due to a shortage of dermatologists, causing long wait times and leading patients to seek dermatologic care from general practitioners. However, the diagnostic accuracy of general practitioners has been reported to be only 0.24-0.70 (compared to 0.77-0.96 for dermatologists), resulting in over- and under-referrals, delays in care, and errors in diagnosis and treatment. In this paper, we developed a deep learning system (DLS) to provide a differential diagnosis of skin conditions for clinical cases (skin photographs and associated medical histories). -
Traction Folliculitis: an Underreported Entity
HIGHLIGHTING SKIN OF COLOR Traction Folliculitis: An Underreported Entity Gary N. Fox, MD; Julie M. Stausmire, MSN, CNS; Darius R. Mehregan, MD Traction folliculitis is a component of traction air and scalp diseases induced by traumatic alopecia syndrome and has received minimal hairstyling techniques, including the use of attention in primary source medical literature. Hchemical relaxers and permanent solutions, The popularity of hairstyles that produce hair hot combs, braids, hair extensions, and pomades, tend traction and the knowledge that early interven- to be underappreciated.1-4 The practice of these tech- tion improves prognosis amplify the importance niques and their sequelae are most common in black of recognizing this entity. Traction folliculitis individuals.1 We present an illustrative scenario of presents as perifollicular erythema and pustules trauma caused by hairstyling techniques in an infant on the scalp in areas where hairstyles produce and review the literature on traction folliculitis. We traction on the hair shaft. In addition to the trac- found no prior reports of traction folliculitis in infants tion, concurrent hair care practices may play a and no prior images of traction folliculitis in the facilitatory role in the development of traction primary source medical literature. folliculitis. Treatment involves immediate removal of traction on hair and temporary alteration of the Case Report facilitatory hair care practices. In more severe An 8-month-old black infant was brought in by his cases, topical or systemic antibacterial therapy mother for evaluation of “pus bumps” on the scalp and, occasionally, topical corticosteroid therapy of several weeks’ duration. The infant was otherwise may be necessary. -
Alopecia with Perifollicular Papules and Pustules
Tyler A. Moss, DO; Thomas M. Alopecia with perifollicular Beachkofsky, MD; Samuel F. Almquist, MD; Oliver J. Wisco, DO; papules and pustules Michael R. Murchland, MD A.T. Still University, Our 23-year-old patient thought his hair loss was Kirksville College of Osteopathic Medicine, probably “genetic.” But that didn’t explain the painful Kirksville, Mo (Dr. Moss); Kunsan AB, Republic of pustules. Korea (Dr. Beachkofsky); Wilford Hall Medical Center, Lackland AFB, Tex (Drs. Almquist, Wisco, and Murchland) A 23-year-old African American man Physical examination revealed multiple sought care at our medical center because perifollicular papules and pustules on the [email protected] he had been losing hair over the vertex of his vertex of his scalp with interspersed patches DEPARTMENT EDITOR scalp for the past several years. He indicated of alopecia (FIGURE 1). Th ere were no lesions Richard P. Usatine, MD that his father had early-onset male patterned elsewhere on his body and his past medical University of Texas Health alopecia. As a result, he considered his hair history was otherwise unremarkable. Science Center at San Antonio loss “genetic.” However, he described waxing and waning fl ares of painful pustules associ- ● The authors reported no WHAT IS YOUR DIAGNOSIS? potential confl ict of interest ated with occasional spontaneous bleeding relevant to this article. and discharge of purulent material that oc- ● HOW WOULD YOU MANAGE curred in the same area as the hair loss. THIS PATIENT? FIGURE 1 Alopecia with a painful twist A B PHOTOS COURTESY OF: OLIVER J. WISCO, DO PHOTOS COURTESY This 23-year-old patient said that he had spontaneous bleeding and discharge of purulent material in the area of his hair loss.