ACSL5 (Human) Recombinant Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Protein (P01) Glutathione, pH=8.0 in the elution buffer.

Storage Instruction: Store at -80°C. Aliquot to avoid Catalog Number: H00051703-P01 repeated freezing and thawing. Regulation Status: For research use only (RUO) Entrez GeneID: 51703 Product Description: Human ACSL5 full-length ORF ( Gene Symbol: ACSL5 NP_057318.2, 1 a.a. - 739 a.a.) recombinant protein with GST-tag at N-terminal. Gene Alias: ACS2, ACS5, FACL5

Sequence: Gene Summary: The protein encoded by this gene is an MDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSL isozyme of the long-chain fatty-acid-coenzyme A ligase EALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLPTPALICI family. Although differing in substrate specificity, LTFGAAIFLWLITRPQPVLPLLDLNNQSVGIEGGARKGV subcellular localization, and tissue distribution, all SQKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLG isozymes of this family convert free long-chain fatty YRKPNQPYRWLSYKQVSDRAEYLGSCLLHKGYKSSP acids into fatty acyl-CoA esters, and thereby play a key DQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPE role in lipid biosynthesis and fatty acid degradation. This AIVHIVNKADIAMVICDTPQKALVLIGNVEKGFTPSLKVII isozyme is highly expressed in uterus and spleen, and in LMDPFDDDLKQRGEKSGIEILSLYDAENLGKEHFRKPV trace amounts in normal brain, but has markedly PPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFL increased levels in malignant gliomas. This gene KCVEHAYEPTPDDVAISYLPLAHMFERIVQAVVYSCGA functions in mediating fatty acid-induced glioma cell RVGFFQGDIRLLADDMKTLKPTLFPAVPRLLNRIYDKV growth. Three transcript variants encoding two different QNEAKTPLKKFLLKLAVSSKFKELQKGIIRHDSFWDKLI isoforms have been found for this gene. [provided by FAKIQDSLGGRVRVIVTGAAPMSTSVMTFFRAAMGCQ RefSeq] VYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYV KLEDVADMNYFTVNNEGEVCIKGTNVFKGYLKDPEKT QEALDSDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQ GEYIAPEKIENIYNRSQPVLQIFVHGESLRSSLVGVVVP DTDVLPSFAAKLGVKGSFEELCQNQVVREAILEDLQKI GKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLKAKRGE LSKYFRTQIDSLYEHIQD

Host: Wheat Germ (in vitro)

Theoretical MW (kDa): 108.7

Applications: AP, Array, ELISA, WB-Re (See our web site product page for detailed applications information)

Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols

Preparation Method: in vitro wheat germ expression system

Purification: Glutathione Sepharose 4 Fast Flow

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