Table of Contents Ordering Information Inside Front Welcome to Diagnostic BioSystems ...... 2 Primary Antibodies ...... 3 FITC Antibodies ...... 117 Detection Systems ...... 118 Polymer Based Detection Systems 118 PolyVue Plus™ Two Step Detection System 119 UnoVue Plus™ One Step Detection System 121 UnoVue™ One Step Detection Reagents 122 Streptavidin Biotin Based Detection Systems 123 Chromogens ...... 124 Chromogens for AP 125 Chromogens for HRP 126 Ancillary Reagents ...... 129 Antigen Retrieval Solutions 129 Buffers 130 Accessory Reagents 130 Special Stains ...... 133 Index I. Product 136 II. Clone 138 III. ASR/RUO Products for U.S. Markets 139 Distributors Inside Back
CATALOG QUICKGUIDE
Find products easily by using this table of contents to identify All antibodies contain the following letter designations with the relevant product area (Antibody, Detection System etc.) and protocol recommendations: go to the corresponding page number for the product area. F = Frozen Each section is color coded for ease of use with products listed P = Formalin Fixed Paraffin Embedded alphabetically within the section. Products can also be found by H = Heat Induced Pretreatment using the product index by name in the back of the catalog. E = Enzyme Pretreatment
All products are noted with their regulatory designation: 3 6 0 Designates antibodies intended for use with IVD In Vitro Diagnostic Use the Montage 360 SYSTEM. RUO Research Use Only Diagnostic BioSystems Primary Antibodies
Diagnostic BioSystems offers an entire range of ready-to-use and concentrated antibodies optimized to provide high quality staining when used for immunohistochemical applications. Our rabbit monoclonal antibodies are also available for enhanced speci city and sharp signal.
We also are pleased to offer the Montage 360 line of routine antibodies optimized for use on the automated Montage 360 system.
FORMAT AND PACK SIZE:
Concentrated Antibodies: Designed for individuals who want to have more exibility in their immunostaining protocols. Each antibody is thoroughly quality control tested to cGMP standards. A recommended dilution factor is provided with each antibody. Pack Size: Concentrated antibodies are available in 1ml and 0.5ml vials. Ready-to-Use Antibodies: These antibodies have been quality control tested and require no further dilution or titration. Pack Size: Ready-to-use antibodies are available in 6ml vials.
Montage 360 Antibodies: These antibodies have been optimized on the Montage 360 system and do not need further dilution.
We recommend the use of these antibodies on the Montage 360 Studies suggest p40 has a markedly higher speci city than p63 while system for optimal results. retaining the same sensitivity for squamous cell carcinoma. This eliminates the potential pitfall of misinterpreting a p63-positive Pack Size: Montage 360 antibodies are available in 10ml pre- adenocarcinoma or unsuspected lymphoma as squamous cell barcoded autostainer vials. carcinoma1. The image shows lung squamous cell carcinoma stained with p40 (PDR055). CATALOG NUMBER GUIDE: The following codes help to identify the antibody source.
CONCENTRATED ANTIBODIES MONTAGE 360 ANTIBODIES READY-TO-USE ANTIBODIES
Mob: Mouse Monoclonal Antibody PDM: Mouse Monoclonal Antibody PDM: Mouse Monoclonal Antibody
RMAB: Rabbit Monoclonal Antibody RMPD: Rabbit Monoclonal Antibody RMPD: Rabbit Monoclonal Antibody
RP: Rabbit Polyclonal Antibody PDR: Rabbit Polyclonal PDR: Rabbit Polyclonal
1) Bishop JA et al, p40 (∆Np63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol. 2012 Mar; 25(3):405-15.
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Page 3-5 Hard Edit.pdf 2 2/17/17 5:10 PM Primary Antibodies 2/17/17 5:10 PM 1 1 1 1 1 1 1 1 111 11 11 11 11 11 www.dbiosys.com erin) 1 erin) 1 1 ) - erin erin - - - - - ost ti A i P osp t se (PSAP) ost ti A i ost te Spe i Anti en (PSA Spe i ost te - et - et epP r-1 epP r-1 P -1 A i ney ( SP erin Spe i SP e is e is Pr rt-1 e n-A ANA ( in stri in) N N NSE p s PA PA PA P 1 Pr S 1 S 1 S 1 S 1 -Resist nt A i P osp t se ( RA P) P osp t se e-Resist nt A i rtr t en s in en s in NF p ( oror p ) Ne rosis F t opoiso er se II opoiso er se i in i in i s or 1 ( 1) or i s 1 ( i s or 1) 1 or ( i s AP . 1 1 1 1 1 1 1 1 1 1 1 1 1 NEW ANTIBODIES in se 1 Ar in se α Fetoprotein (AFP) (AFP) α Fetoprotein A ( - er in ) α Fetoprotein (AFP) (AFP) α Fetoprotein α-1-Antitrypsin (SERPINA1) in se 1 Ar in se - - r er) or A ( I A1 - Si y e is A A1 - Si y e is ( - es on) es on ponin-1 tenin 1 A1 e 11 1 S A1 NFRSF 1 PE A -1 I E A E A A ro o r nin A ro o r nin y in 1 yto er tin A i i yto er tin yto er tin es o ein-1 E- erin Ep- A Ep- A Ep- A F s in-1 Ferritin i t in FS -Re eptor A y op orin ypi n- ( P ) ypi n- ( P ) ( FP-1 ) Protein ysti ise se F i ross ro t or one Page 3-5 Hard Edit.pdf 3 Page 6-11 Hard Edit.pdf 1 Primary Antibodies www.dbiosys.com RP047 1 7 muscle but not in non-sarcomeric muscle elements. actinin. It stains Z lines and dots in stress fibers of myotubes in skeletal and cardiac Specificity: Cellular Localization: Cytoplasmic Positive Control: Skeletal muscle Isotype: Immunogen: Status:Regulatory IVD Mob227-05Concentrated 0.5ml Catalog No.: Clone: Regulatory Status:Regulatory IVD PD 02 -10 PP PD 02 P P047-05C Catalog No.: P047C --nihmtysn α-1-Antichymotrypsin Poly α-Actinin, Sarcomeric Monoclonal MouseAnti- uman antibody stains monocytes and macrophages in human tissues and does not stain does any other and cell tissues type. human in macrophages and monocytes stains antibody Specificity: Cellular Localization: Positive Control: Immunogen: ------clonal abbit Anti- uman clonal abbit A-5 IgG1 This antibody is specific for α-skeletal muscle actinin and α-cardiac α-cardiac and actinin muscle α-skeletal for specific is antibody This The antibody is specific against human α-1-antichymotrypsin. This α-1-antichymotrypsin. human against specific is antibody The
Mob227 Concentrated 1ml Purified rabbit skeletal α-actinin α-1-antichymotrypsin α-1-antichymotrypsin isolated from human serum Tonsil oncentrated 1ml Cytoplasmic r ediluted ml oncentrated 0.5ml rediluted 10ml 0 F F , ,/ P P H stains macrophages in human tissues and does not stain any other cell type. Specificity: Cellular Localization: Positive Control: Immunogen: 04 1 RP Regulatory Status:Regulatory IVD --nirpi Status:Regulatory IVD PD 021Prediluted ml P04 -05Concentrated0.5ml Catalog No.: α-1-Antitrypsin Poly PDM2 2-10MMPrediluted 10ml PDM2 2Prediluted ml Catalog No.: Mob504Concentrated 1ml Clone: (S RPINA1) α-1-Antitrypsin Monoclonal MouseAnti- uman with fibrosis of uncertain origin. disease liver of forms other or cirrhosis cryptogenic with patients of screening the in tool useful a also is antibody nature. This histiocytic of lesions malignant Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: 1 RP04 ------clonal abbit Anti- uman clonal abbit DBM15. 0 IgG The antibody is specific against human α-1-antitrypsin. This antibody oiie tiig o AT s lo sd n eeto o bng and benign of detection in used also is AAT for staining Positive
P04 Concentrated1ml α-1-antitrypsin α-1-antitrypsin isolated from human serum ecombinant Āhuman Alpha-1- Antitrypsin (AAT) protein fragment Tonsil epatocellular Ācarcinoma Cytoplasmic Cytoplasmic 0 F F , , P P NEW 2/17/17 5:10PM Primary Antibodies 2/17/17 5:10 PM NEW NEW www.dbiosys.com P P , , F F 0 0 rediluted 10ml rediluted ediluted ml ediluted ml oncentrated 1ml oncentrated 1ml r Cytoplasmic Cytoplasmic epatocellular Ācarcinoma Fetal liver, placenta liver, Fetal ever, ever, hereditary persistence of alpha-fetoprotein may also be ever, hereditary persistence of α-fetoprotein may also be found in found be also may α-fetoprotein of persistence hereditary ever, Alpha fetoprotein (AFP) purified from serum of a hepatoma patient hepatoma a of serum from purified (AFP) fetoprotein Alpha uman ĀAlpha fetoprotein uman ĀAlpha AFP expression in adults is often associated with hepatoma or AFP expression in adults is often associated with hepatoma or PDM2 7-10MM P ow ow IgG1, kappa IgG1, IgG2a, kappa IgG2a, DBM15. 5 DBM15.1 4 ------Monoclonal Mouse Anti- uman (AFP) α Fetoprotein Monoclonal Mouse Anti- uman Monoclonal (AFP) α Fetoprotein Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: teratoma. individuals with no obvious pathology. The protein is thought to be counterpart the of fetal serum albumin, and in the found is AFP AFP and 4. albumin chromosome genes on are orientation present transcriptional in same the in tandem fatty nickel, and binds copper, as dimeric and trimeric forms, monomeric as well loss renal measure to used is fluid amniotic in AFP of level The bilirubin. and acids anencephaly. and bifida spinal for screen to protein of Clone: Mob50 C No.: Catalog PDM2 7 P Clone: Mob4 C No.: Catalog Pr PDM202 IVD Regulatory Status: 10ml PDM202-10MM Prediluted Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: teratoma. the be to thought is protein The pathology. obvious no with individuals in found present are genes albumin and AFP the and albumin, serum counterpartof fetal found is AFP 4. chromosome on orientation transcriptional same the in tandem in fatty nickel, copper, binds and forms, trimeric and dimeric as well as monomeric in loss renal measure to used is fluid amniotic in AFP of level The bilirubin. and acids anencephaly. and bifida spinal for screen to protein of Regulatory Status: IVD Regulatory Status: 0 7 P P , , F F 0 oncentrated 0.5ml oncentrated 0.5ml ediluted ml ediluted ml oncentrated 1ml r Cytoplasmic Cytoplasmic oncentrated 1ml Fetal liver Fetal Fetal liver Fetal BALBC Āmice were injected with purified human α-fetoprotein. human purified with injected were BALBC Āmice α-1-fetoprotein isolated from human cord serum cord human from isolated α-1-fetoprotein α-fetoprotein α-fetoprotein (AFP) is a single chain glycoprotein of 70 kDa that is PD 01 P This antibody reacts with A α-1-fetoprotein. positive staining in the IgG2a C clonal abbit Anti- uman ------ 1 RP001 Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: Immunogen: Control: Positive Localization: Cellular Specificity: Monoclonal Mouse Anti- uman (AFP) α Fetoprotein Poly α-1-Fetoprotein (AFP) (AFP) α-1-Fetoprotein normally expressed in the fetal liver, gastrointestinal antibody tract recognizes an epitope of and α-fetoprotein present in human yolk and several sac. This species. other Clone: Mob12 C No.: Catalog Mob12 -05 C 10ml PDM057-10MM Prediluted IVD Regulatory Status: PDM057 Pr hepatocytes of fetal tissue was This observed.antibody does not react with any types. tissue or cell other
P001-05 C P001-05 IVD Regulatory Status: P001 C No.: Catalog 1 Page 6-11 Hard Edit.pdf 2 Page 6-11 Hard Edit.pdf 3 Primary Antibodies www.dbiosys.com Formalin fixed stainedwithACTH paraffin antibody(Mob512). embeddedhumanpituitary antibody (Mob001). Formalin fixed paraffin embeddedhumanleiomyomastainedwithActin, α-SmoothMuscle causing paraneoplastic syndromes by secreting ACT . withothertumors(e.g. alsomay react somesmallcellcarcinomas ofthelung) It the study of pituitary disease. It reacts with ACT -producing cells (corticotrophs). Specificity: Cellular Localization: Positive Control: Isotype: ( GA D SA AFPL F) Status:Re ulatory I actin actin isoforms αmyocardial and α-sarcomeric γ-cytoplasmic, and β with cross-react not does antibody This parenchymes. different and vessels of cells muscle smooth with Specificity: Cellular Localization: Positive Control: Isotype: smooth muscle actin. PDM247-10MMPrediluted 10ml PDM247Prediluted ml Catalo No : Mob512Concentrated 1ml Clone: Immuno en: Immuno en: Status:Re ulatory I PDM00 -10MMPrediluted 10ml PDM00 Prediluted ml Mob001-05Concentrated 0.5ml Catalo No : Mob001Concentrated 1ml Clone: ci,αSot uce uscle α-Smooth Actin, Monoclonal MouseAnti- uman C (-emnl AC (C- erminal) Monoclonal MouseAnti- uman ------DBM15. 1A4 IgG IgG2a, kappa This antibody is specific to α-smooth muscle isoform of actin. It reacts Anti-ACT is a useful marker in classification of tumors pituitary and dcppie f α- of decapeptide -terminal with injected were mice BALB C o hmn ACT human of aa25- to corresponding peptide Synthetic Pituitary Pituitary gland Leiomyoma, colon Cytoplasmic Cytoplasmic 0 0 F F , , P P NEW . (Mob002). Formalin fixed paraffin embeddedhumanskeletal musclestainedwithActin, Muscleantibody antibody (Mob235). Formalin fixed paraffin embeddedhumanuterusleiomyomastainedwithActin, Pan Muscle i.e. leiomyosarcoma and rhabdomyosarcoma. Specificity: Cellular Localization: Positive Control: Isotype: 5C5. for actin muscle striated rabbit purified with and 1A4 for actin muscle smooth actin actin isomers. γ muscle nonsmooth and recognizeβ not does but muscle smooth and cardiac Specificity: Cellular Localization: Positive Control: Isotype: myocardium. Immuno en: Status:Re ulatory I PDM002-10MMPrediluted 10ml PDM002Prediluted ml Mob002-05Concentrated 0.5ml Catalo No : Mob002Concentrated 1ml Clone: Immuno en: Status:Re ulatory I Mob2 5-05C Catalo No : Mob2 5C Clone: ci, sl uscle Actin, Monoclonal MouseAnti- uman ci,Pn sl PanActin, uscle Monoclonal MouseAnti- uman ------ F 5 1A4 5C5 1A4, IgG2a, kappa; 5C5, IgM IgG1, kappa This pan actin is useful in identifying tumors arising from muscle cells, This antibody is specific to α and γ specific actin isomers from skeletal, BALB C mice were injected with SDS extracted protein from human BALB C Skeletal muscle, leiomyoma Skeletal muscle Cytoplasmic Cytoplasmic ie ee netd with injected were mice oncentrated 1ml oncentrated 0.5ml 0 -terminal F F , , P P eaetd o α- of decapeptide 2/17/17 5:10PM Primary Antibodies 2/17/17 5:10 PM www.dbiosys.com P P , , F F 3 6 0 Cytoplasmic Cytoplasmic Pituitary Pituitary BALB/C mice were injected with a synthetic peptide corresponding corresponding peptide synthetic a with injected were mice BALB/C Synthetic human ACTH 1-24. ACTH human Synthetic This antibody reacts with human ACTH. This antibody cross-reacts This antibody is specific to an epitope on the N-terminus of ACTH. IgG1 AH26 ------Polyclonal Rabbit Anti-Human Polyclonal Monoclonal Mouse Anti-Human Monoclonal (ACTH) Hormone Adrenocorticotropic This antibody stains corticotrophs in the adenohypophysis and is useful in the adenomas. pituitary of classification Immunogen: ACTH. human of N-terminal the from 1-24 acids toamino Isotype: Control: Positive Localization: Cellular Specificity: Hormone (ACTH)Adrenocorticotropic Clone: 1ml Mob244 Concentrated No.: Catalog 0.5ml Concentrated Mob244-05 IVD Regulatory Status: Immunogen: Control: Positive Localization: Cellular Specificity: RP045 Concentrated 1ml RP045 Concentrated No.: Catalog 0.5ml RP045-05 Concentrated 6ml PDR022 Prediluted 10ml PDR022-10RP Prediluted IVD Regulatory Status: with ACTH in a adsorption. phase wide solid by variety removed been of have mammalian antibodies species. Traces of contaminating Formalin fixed paraffin embedded human pituitary antibody (PDR022). paraffin stained with ACTH fixed Formalin Formalin fixed paraffin embedded human pituitary antibody (Mob244). paraffin stained with ACTH fixed Formalin 9 H P P ,/ , F F 3 6 0 (Only for markets outside the U.S. For U.S. market, see index III.) see index market, U.S. For outside the U.S. markets for (Only Nuclear Cytoplasmic Adenovirus infected tissue infected Adenovirus Skeletal muscle Skeletal BALB/C mice were injected with purified rabbit striated muscle BALB/C mice were injected with adenovirus. with injected were mice BALB/C This antibody reacts with adenovirus. The adenovirus early gene Monoclonal anti-α-sarcomeric actin has been used as a marker for M58, IgG2a, kappa; M73, IgG2a, kappa IgG2a, M73, kappa; IgG2a, M58, IgM M58 + M73 5C5 ------Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: Monoclonal Mouse Anti-Human Adenovirus Clone: 1ml Mob355 Concentrated No.: Catalog 0.5ml Mob355-05 Concentrated IVD Regulatory Status: Monoclonal Mouse Anti-Human Monoclonal Actin, Sarcomeric Immunogen: actin. Isotype: Control: Positive Localization: Cellular Specificity: Regulatory Status: IVD Regulatory Status: Clone: 1ml Mob128 Concentrated No.: Catalog 0.5ml Concentrated Mob128-05 6ml Prediluted PDM099 10ml Prediluted PDM099-10MM product E1A is a potent stimulator of cellular proliferation, which when rhabdomyosarcoma. This antibody is specific to α-skeletal and α-cardiac muscle rhabdomyosarcoma. tissue. muscle smooth with react not does It actins. overexpressed overexpressed can overcome the growth-inhibitory effects of TGF-β. The E1A region encodes a series of related proteins capabilities (35-46 and kDa) with forms multifunctional a specific complex with the retinoblastoma tumor suppressor gene product. The E1A of E1A alone is sufficient to While expression of adenovirus. region and transforming E1B regions together comprise immortalize the primary cells, region. E1B complete the of expression transformation requires the additional Infected adenovirus cells stained with Adenovirus antibody (Mob355). stained with Adenovirus Infected adenovirus cells Formalin fixed paraffin embedded human skeletal muscle stained with Actin, Sarcomeric antibody stained with Actin, muscle embedded human skeletal paraffin fixed Formalin (Mob128). Page 6-11 Hard Edit.pdf 4 Monoclonal Mouse Anti-Human Polyclonal Rabbit Anti-Human Arginase 1 F, P NEW Albumin F, P Clone: DBM15.12 Catalog No.: RP046 Concentrated 1ml Catalog No.: Mob484 Concentrated 1ml RP046-05 Concentrated 0.5ml PDM197 Prediluted 6ml PDM197-10MM Prediluted 10ml 3 6 0 Regulatory Status: IVD
Regulatory Status: IVD
Formalin fixed paraffin embedded human liver stained with Albumin antibody (RP046). Immunogen: Purified human albumin. Formalin fixed paraffin embedded hepatocellular carcinoma stained with Arginase 1 (Mob484). Positive Control: Liver Immunogen: Recombinant fragment (87 Amino acid residues around aa 1-150) Cellular Localization: Cytoplasmic of human ARG1 protein Specificity: This antibody reacts with human albumin. This antibody is free of Isotype: IgG3, kappa other rabbit serum proteins. Specificity is determined by Ouchterlony double Positive Control: Hepatocellular carcinoma diffusion (ODD) and immunoelectrophoresis (IEP) versus human serum and Cellular Localization: Cytoplasmic human albumin. Specificity: Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of ------arginine to generate ornithine and urea. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and Monoclonal Mouse Anti-Human specific marker for identification of hepatocellular carcinoma. Amyloid A Component F, P ------Clone: mcl Catalog No.: Mob003 Concentrated 1ml Mob003-05 Concentrated 0.5ml Monoclonal Mouse Anti-Human PDM118 Prediluted 6ml Arginase 1 F, P NEW PDM118-10MM Prediluted 10ml 3 6 0
Primary Antibodies Clone: DBM15.13 Catalog No.: Mob488 Concentrated 1ml Regulatory Status: IVD PDM201 Prediluted 6ml PDM201-10MM Prediluted 10ml 3 6 0
Regulatory Status: IVD
Formalin fixed paraffin embedded human amyloidosis stained with Amyloid A Component antibody (Mob003). Immunogen: Human amyloid A protein coupled to horseradish peroxidase and kininogen. Formalin fixed paraffin embedded hepatocellular carcinoma stained with Arginase 1 (Mob488). Isotype: IgG2a, kappa Immunogen: Recombinant fragment (87 Amino acid residues around aa 1-150) Positive Control: Kidney of human ARG1 protein Cellular Localization: Extracellular Isotype: IgG3, kappa Specificity: This antibody reacts with amyloid deposits in all organs and tissues. It Positive Control: Hepatocellular carcinoma reacts specifically with amyloid A protein in the native fibrils as well as fixed fibrils Cellular Localization: Cytoplasmic but does not show any reactivity with non-amyloid A fibril protein. Specificity: Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.
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Page 6-11 Hard Edit.pdf 5 2/17/17 5:10 PM Primary Antibodies 2/17/17 5:10 PM M) ( P M-AL Ā P www.dbiosys.com P , F P , F ) gene and the nucleophosmin AL ediluted ml r uclear Cytoplasmic andor Ānuclear Cytoplasmic Prostate carcinoma Prostate Anaplastic lymphoma Anaplastic AB007 Concentrated 0.5ml AB007 Concentrated om the t(2;5)(p2 ;q 5) translocation found in 0-50 of CD 0 om the t(2;5)(p2 ;q 5) translocation found ecombinant Āprotein corresponding to a ecombinant Āprotein region which spans the BALBC Āmice were injected with a synthetic peptide corresponding corresponding peptide synthetic a with injected were BALBC Āmice This antibody is specific to a protein of 110 kDa, identified as This antibody recognizes a human p0 Āprotein, identified as a hybrid hybrid a as identified p0 Āprotein, human a recognizes antibody This IgG1 IgG SP A 441 ------Immuno en: Monoclonal Mouse Anti- uman Receptor Andro en Monoclonal abbitMonoclonal Anti- uman p (AL ) inase Lymphoma Anaplastic Immuno en: MPD007 P MPD007 I Re ulatory Status: Clone: M No : Catalo Clone: 1ml Mob245 Concentrated No : Catalo 0.5ml Mob245-05 Concentrated ml Ā PDM1 7 Prediluted I Re ulatory Status: receptor. androgen human the to Isotype: Control: Positive Localization: Cellular Specificity: androgen This receptor. antibody reacts with full length A Āand also with the This antibody does not newly cross-react with described A form of the receptor. receptors. glucocorticoid or progesterone estrogen, tyrosine tyrosine kinase catalytic domain and part of the transcript. C-terminus of the Isotype: Control: Positive Localization: Cellular Specificity: of the anaplastic lymphoma kinase ( fr gene resulting p0 Ā detect to used be can antibody monoclonal rabbit This lymphomas. cell large subtype described recently a detect to used be also may and lymphomas these in of large B cell lymphoma, which expresses the full-length AL Āprotein. full-length the expresses which lymphoma, cell B large of Formalin fixed paraffin embedded human prostate stained with Androgen Receptor antibody embedded human prostate stained with Androgen Receptor paraffin fixed Formalin (Mob245). Formalin fixed paraffin embedded human anaplastic lymphoma stained ALK antibody (RMAB007). paraffin fixed Formalin 11 P P , , F F APP751 and APP770. Amyloid APP 5, oncentrated 0.5ml Cytoplasmic, extracellular Cytoplasmic, Cytoplasmic oncentrated 1ml Brain Brain, amyloidosis Brain, A synthetic peptide corresponding to C-terminal of human APP. human of C-terminal to corresponding peptide synthetic A A synthetic β-amyloid peptide (1-40) conjugated to L . conjugated (1-40) peptide β-amyloid synthetic A This antibody reacts with a 5-100 Ā kDa protein. This antibody This antibody reacts with β-amyloid protein. This antibody stains IgG1 BAM-10 clonal abbit Anti- uman ------Monoclonal Mouse Anti- uman Protein β-Amyloid Immuno en: Control: Positive Cellular Localization: Localization: Cellular Specificity: recognizes amyloid precursor proteins a with glycoproteins transmembrane are proteins like APP and protein precursor structure. domain modular similar Catalo No : P12 C No : Catalo I Re ulatory Status: Poly (APP) Protein Precursor Amyloid C P12 -05 Cellular Localization: Localization: Cellular Specificity: amyloid plaques within the cortex and amyloid deposits amyloid in deposits blood are also vessels. detected β- in Lewy body dementia, Down syndrome, amyloidosis and, in The Gram-Parkinson presence of dementia a complex. large number of neuritic plaques (senile) and major the neurofibrillary presents and state tangles disease a for in marker pathological a the as used is cerebral cortex autopsy. at disease Alzheimer’s of diagnosis the for criterion Immuno en: Isotype: Control: Positive Clone: 1ml Mob410 Concentrated No : Catalo 0.5ml Mob410-05 Concentrated I Re ulatory Status: Formalin fixed paraffin embedded amyloidosis stained with β-Amyloid Protein (Mob410). embedded amyloidosis stained with β-Amyloid Protein paraffin fixed Formalin Formalin fixed paraffin embedded human brain stained with APP (RP123). embedded human brain paraffin fixed Formalin Page 6-11 Hard Edit.pdf 6 Page 12-16 Hard Edit.pdf 1 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithBcl-2Oncoprotein (PDM016). Formalin fixed paraffin embeddedtonsilstainedwithBcl-2antibody(RMAB047). protein and small number in which neoplastic cells are bcl-2 negative. be used in distinguishing between those follicular lymphomas that express bcl-2 between reactive distinguishing and neoplastic follicular when proliferation in valuable lymph node biopsies. is It may also antibody This negative. are centers germinal hyperplastic or normal the whereas protein, alpha bcl-2 of levels death high cell programmed express centers germinal the neoplastic lymphomas, follicular most inhibits In (apoptosis). oncoprotein alpha bcl-2 of Expression antibody. Bcl-2 other any than higher is lymphoma follicular of diagnosis in antibody this of sensitivity cancer.The colon and cancer endometrial cancer, ovarian cancer, prostate cancer, breast in prognosis disease with correlated be to shown been expressionhas bcl-2 follicularreactiveproliferationaddition, negative).In (bcl-2 Specificity: Cellular Localization: Positive Control: Isotype: BH4 of human Bcl-2 protein. Immunogen: Status:Regulatory IVD RMPD047Prediluted 6ml Catalog No.: RMAB047 Concentrated 0.5ml Clone: lh ocpoen I sos o rs-ecin ih c- o Bx protein. Bax or Bcl-x with cross-reaction no shows It oncoprotein. alpha Status:Regulatory IVD PDM016-10MMPrediluted 10ml PDM016Prediluted 6ml Mob005-05Concentrated 0.5ml Catalog No.: Mob005Concentrated 1ml Clone: Specificity: Cellular Localization: Positive Control: Isotype: acidsof bcl-2 oncoprotein. c- norti OncoproteinBcl-2 Monoclonal MouseAnti-Human OncoproteinBcl-2 Anti-Human Monoclonal Rabbit Immunogen: ------EP36 124 Rabbit Rabbit IgG IgG1, kappa Bcl-2 antibody is useful in differentiation of follicular lymphoma from This antibody recognizes a protein of 25-26kDa, identified as bcl-2 as identified 25-26kDa, of protein a recognizes antibody This Recombinant bcl-2 peptide sequence comprising of 51-54 amino 51-54 of comprising sequence peptide bcl-2 Recombinant A synthetic peptide corresponding to residues between BH3 and BH3 between residues to corresponding peptide synthetic A Tonsil, follicular lymphoma Tonsil Cytoplasm Cell membrane 3 60 F F ,/ ,/ P P H H 12 Formalin fixed paraffin embeddedhumantonsilstainedwithBcl-2Oncoprotein (Mob130). Formalin fixed paraffin embeddedhumantonsilstainedwithBcl-6(Mob501). hra te el i nolsi flils xii mmrn sann. c- α Bcl-2 staining. membrane exhibit follicles oncoprotein has been neoplastic bcl-2, shown to for in inhibit apoptosis. staining cells no the show whereas follicles Reactive pathway. production cell B the of part forms apoptosis where centers germinal in inhibited is expression Bcl-2 Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: Status:Regulatory IVD Mob130-05Concentrated 0.5ml Catalog No.: Mob130Concentrated 1ml Clone: c- norti OncoproteinBcl-2 Monoclonal MouseAnti-Human cell phenotypes. CD10, Bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B- where (DLBCL), lymphomas B-cell large diffuse in marker prognostic an important is lymphomas.Bcl-6 B-cell non-Hodgkin in translocations chromosomal by Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: PDM229-10MMPrediluted 10ml Status:Regulatory IVD PDM229Prediluted 6ml Catalog No.: Mob501Concentrated 1ml Clone: Bcl-6 Monoclonal MouseAnti-Human ------100/D5 DBM15.27 IgG1 IgG1, kappa Bcl-6 was first identified as a proto-oncogene frequently deregulated The bcl-2 product is considered to act as an inhibitor of apoptosis. of inhibitor an as act to considered is product bcl-2 The BALB/C mice were injected with synthetic bcl-2 peptide. Recombinant human Bcl-6 protein. Tonsil Tonsil Cell membrane Nuclear 3 60 F F ,/ , P P H NEW 2/17/17 5:11PM Primary Antibodies 2/17/17 5:11 PM www.dbiosys.com H H P P ,/ ,/ F F Nuclear Cytoplasmic, cell/nuclear membrane cell/nuclear Cytoplasmic, Tonsil Hodgkin’s lymphoma Hodgkin’s A synthetic peptide corresponding to aa 46-66 of the human Bcl-X Bcl-X human the of 46-66 aa to corresponding peptide synthetic A Human recombinant Bcl-10. recombinant Human Monoclonal anti-bcl-10 reacts specifically with human bcl-10. The This antibody reacts with a ~27 kDa protein. Bcl-X is a member of the of member a is Bcl-X protein. kDa ~27 a with reacts antibody This IgG1 151 ------Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: Rabbit Anti-Human Polyclonal Marker Apoptosis Bcl-X, Monoclonal Mouse Anti-Human Monoclonal Bcl-10 Clone: 1ml Mob442 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob442-05 Concentrated human of 122-168 acids amino within resides antibody the by recognized epitope bcl-10 molecule. Bcl-10, also designated as It protein. containing domain) CIPER, recruitment (caspase CARD N-terminal an is mE10, cE10, CLAP, CARMEN, and E-10 (vCLAP). Bcl-10 is a cellular homologue of the equine herpesvirus-2 protein was implicated in the regulation of apoptosis by enhancing interacting procaspase with 9 caspase processing, 9, and triggering its activation when Immunogen: protein. Control: Positive Localization: Cellular Specificity: has two Bcl-X of apoptosis. which function as regulators acid bcl-2 family of proteins, amino 178 a (short) Bcl-Xs and protein acid amino 241 a (long) Bcl-XL isomers, of members among conserved well is that domain acid amino 63 a lacking protein family. bcl-2 the RP126 Concentrated 1ml RP126 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml RP126-05 Concentrated overexpressed in the cell. Bcl-10 cellular overexpression induces JNK, p38, and NF- and p38, JNK, induces overexpression cellular Bcl-10 cell. the in overexpressed kB activation. Deregulation of bcl-10 expression was also demonstrated oncogenesis. to cellular be in involved Formalin fixed paraffin embedded human Hodgkin’s lymphoma stained with Bcl-X (RP126). embedded human Hodgkin’s paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with Bcl-10 (Mob442). paraffin fixed Formalin 13 NEW H P P ,/ , F F 3 6 0 3 6 0 Nuclear Tonsil Tonsil Recombinant human bcl-6 protein. bcl-6 human Recombinant This This antibody reacts with the Bcl-6 gene product in follicular This antibody recognizes a protein of 95kDa, which is identified as Rabbit IgG Rabbit IgG2b. DBR16.6 LN22 ------Bcl-6 Oncoprotein Bcl-6 Oncoprotein Monoclonal Mouse Anti-Human Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are negative. usually (2) Bcl-6 is an important lymphomas (DLBCL), prognostic where marker CD10, bcl-6 in and diffuse MUM1/IRF4 are large used germinal B-cell center to and identify activated B-cell phenotypes. (3) Bcl-6 can be distinguishing valuable classical in Hodgkin lymphoma from nodular lymphocyte Clone: 0.5ml Concentrated RMAB091 No.: Catalog IVD Regulatory Status: 1ml Concentrated RMAB091-1 6ml RMPD091 Prediluted 10ml RMPD091-10RM Prediluted Monoclonal RabbitMonoclonal Anti-Human Bcl-6 Isotype: Control: Positive Nuclear Localization: Cellular Specificity: Regulatory Status: IVD Regulatory Status: Clone: 1ml Mob468 Concentrated No.: Catalog 0.5 ml Mob468 Concentrated 6ml PDM176 Prediluted 10ml PDM176-10MM Prediluted predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical The Reed-Sternberg Hodgkinpredominant lymphoma (NLPHL). Hodgkin lymphoma are bcl-6 whereas the negative large (“L&H”) cells of NLPHL are Inbcl-6 positive. anti-Bcl-6 stains contrast, rarely mantle-cell lymphoma and lymphoma. MALT lymphomas, diffuse large B cell lymphomas, Burkitt’s lymphomas, and in nodular, nodular, in and lymphomas, Burkitt’s lymphomas, cell B large diffuse lymphomas, lymphocyte predominant Hodgkin’s disease. Bcl-6 is encodes Kruppel-type a Zinc-finger protein of 95 kDa and proto-oncogeneshares homology with that transcription factor. Bcl-6 is mainly expressed in normal germinal center B cells lymphomas. related and Formalin fixed paraffin embedded human tonsil stained with Bcl-6 (RMAB091). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with Bcl-6 antibody (Mob468). paraffin fixed Formalin Page 12-16 Hard Edit.pdf 2 Monoclonal Mouse Anti-Human Monoclonal Mouse Anti-Human Bcl-X, Apoptosis Marker F,/ P H BRCA1 F,/ P H Clone: 2H12 Clone: GLK-2 Catalog No.: Mob248 Concentrated 1ml Catalog No.: Mob424 Concentrated 1ml Mob248-05 Concentrated 0.5ml Mob424-05 Concentrated 0.5ml
Regulatory Status: IVD Regulatory Status: IVD (Only for markets outside the U.S. For U.S. market, see index III.)
Formalin fixed paraffin embedded Hodgkin's lymphoma stained with Bcl-X antibody (Mob248). Formalin fixed paraffin embedded ovarian cancer stained with BRCA1 antibody (Mob424). Immunogen: BALB/C mice were injected with a synthetic peptide of amino acid Immunogen: Peptide corresponding to amino acids 1839-1863 of the C- 3-14 (Cys-QSNRELVVDFLS) of human bcl-X protein. terminus of BRCA1. Isotype: IgG2a Isotype: IgM, kappa Positive Control: Hodgkin’s lymphoma Positive Control: Ovarian carcinoma Cellular Localization: Cytoplasmic, cell membrane Cellular Localization: Cytoplasmic Specificity: This antibody recognizes a 27 kDa protein identified as bcl-X protein. Specificity: BRCA1 recognizes a 22kDa protein. This antibody stains 94% of This antibody is highly specific to bcl-X and does not show cross-reactivity with ovarian carcinomas with a mutation in exon 11. However, staining was absent in bcl-2 α or bax protein. 100% of tumors with mutations other than exon 11. ------
Monoclonal Mouse Anti-Human Monoclonal Mouse Anti-Human BOB.1/OBF F,/ P H C4D F,/ P H Clone: Wue-AC5 Clone: C4D204 Catalog No.: Mob445 Concentrated 1ml Catalog No.: Mob471 Concentrated 1ml Mob445-05 Concentrated 0.5ml Mob471-05 Concentrated 0.5ml Primary Antibodies PDM184 Prediluted 6ml 3 6 0 Regulatory Status: IVD (Only for markets outside the U.S. For U.S. market, see index III.) Regulatory Status: IVD
Formalin fixed paraffin embedded human tonsil stained with BOB.1 (Mob445). Immunogen: A recombinant BOB.1/OBF.1 protein from C-terminal domain. Formalin fixed paraffin embedded human rejected kidney stained with C4D (Mob471). Isotype: IgG2a Immunogen: A recombinant fragment specific to Complement 4d. Positive Control: Tonsil Isotype: Mouse IgG1 Cellular Localization: Cell membrane Positive Control: Membrane Cytoplasm Specificity: B cell-specific octamer binding protein-1 (BOB-1) is a lymphocyte- Cellular Localization: Rejected kidney specific transcription co-activator protein. B cell-specific transcription is Specificity: Complement 4d (C4d) is the most clinically used marker for humoral mediated by octamer motifs found in immunoglobulin heavy and light chain rejection. It is a degradation product of the activated complement factor C4b. gene promoters and in some immunoglobulin enhancers. These sites are bound Complement 4d is typically initiated by binding of antibodies to specific target by the B cell-specific Oct1and Oct2 transcription factors, and the B-cell restricted molecules. Following activation and degradation of the C4 molecule, thio-ester co-activator BOB.1/OBF.1. This protein interacts only with the Oct1/2 proteins groups are exposed, which allow transient, covalent binding of the degradation through sub domains in the POU domain of the Oct1/2 proteins. product complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. Complement 4d is also found in intracytoplasmic vacuoles of endothelial cells. Covalent binding renders C4d a stable molecule that can easily be detected by immunohistochemistry.
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,/ ,/ F F 3 6 0 3 6 0
Cytoplasmic Colon carcinoma Colon Precipitin Precipitin lines obtained after immuno-diffusion using MAb 116- Purified human CA19-9 protein. CA19-9 human Purified PDM238-10MM Prediluted 10ml PDM238-10MM Prediluted In normal tissues, Sialyl Lewis A antigen is present in ductal IgM, kappa IgM, IgG DBM15.36 DBR16.14 ------Immunogen: Isotype: carcinoma Colon Control: Positive Cytoplasmic Localization: Cellular Specificity: In normal tissues, Sialyl Lewis A antigen is present in ductal Monoclonal Mouse Anti-Human A CA19-9/Sialyl Lewis Monoclonal RabbitMonoclonal Anti-Human Marker)Tumor A (GI CA19-9/Sialyl Lewis Clone: 1ml Mob510 Concentrated No.: Catalog 6ml PDM238 Prediluted Clone: 0.5ml Concentrated RMAB099 No.: Catalog 6ml Prediluted RMPD099 10ml Prediluted RMPD099-10RM IVD Regulatory Status: 1ml Concentrated RMAB099-1 Immunogen: Regulatory Status: IVD Regulatory Status: epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is expression Its glands. sweat and gland, salivary kidney, breast, the of epithelium NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le). patient A+B- Lewis a of cyst ovarian an from isolated mucins and NS-19-9 Isotype: Control: Positive Localization: Cellular Specificity: greatly greatly enhanced in serum as well as in the majority of tumor cells in epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is expression Its glands. sweat and gland, salivary kidney, breast, the of epithelium gastrointestinal gastrointestinal (GI) carcinomas, including adenocarcinomas of the intestine, and stomach, pancreas. Preoperative elevated CA19-9 When surgery. following levels values normal to decrease carcinoma in pancreatic I stage patients with used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings. This MAb is excellent for staining tissues. embedded of formalin-fixed, paraffin- greatly greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal gastrointestinal (GI) carcinomas, including adenocarcinomas of the intestine, stomach, and pancreas. Preoperative elevated CA19-9 When levels surgery. following values normal to in decrease carcinoma pancreatic I stage patients with used serially, CA19-9 can predict recurrence of disease prior to radiographic or findings. clinical Formalin fixed paraffin embedded human colon stained with CA19-9/Sialyl Lewis A (Mob510). with CA19-9/Sialyl Lewis stained embedded human colon paraffin fixed Formalin Formalin fixed paraffin embedded ovarian cancer stained with Bcl-2 antibody (RMAB047). cancer embedded ovarian paraffin fixed Formalin Formalin fixed paraffin embedded human colon stained with CA19-9/Sialyl Lewis A (RMPD099). Lewis stained with CA19-9/Sialyl embedded human colon paraffin fixed Formalin 15 H H P P ,/ ,/ F F Cytoplasmic Cytoplasmic, cell membrane cell Cytoplasmic, Colon carcinoma Colon Breast carcinoma Breast Human colorectal adenocarcinoma cell line COLO 205. COLO line cell adenocarcinoma colorectal Human Human breast cancer cell line ZR-75-1. line cell cancer breast Human This antibody is specific to epithelial membrane antigen (EMA), CA This antibody reacts specifically with sialyl Lewisa and recognizes an recognizes and Lewisa sialyl with specifically reacts antibody This IgG1 IgG1, kappa IgG1, C241:5:1:4 DBMM1 ------Cellular Localization: Localization: Cellular Specificity: epitope being designated CA 19-9. It does Lewisb. not CA cross-reacts 19-9 with Lewisa has and been cancers. gastrointestinal shown of management to be useful marker in the diagnosis and Immunogen: Isotype: Control: Positive Clone: 1ml Mob109 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob109-05 Concentrated Cellular Localization: Localization: Cellular Specificity: Monoclonal Mouse Anti-Human CA 19-9 Immunogen: Isotype: Control: Positive Clone: 1ml Mob134-1 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob134-1-05 Concentrated 6ml PDM059-1 Prediluted Monoclonal Mouse Anti-Human Monoclonal CA 15-3 15-3, or polymorphic epithelial mucin. This antibody stains an underglycosylated underglycosylated an stains antibody This mucin. epithelial polymorphic or 15-3, cells. carcinoma on present often MUC1 Formalin fixed paraffin embedded colon cancer stained with CA 19-9 antibody (Mob109). cancer embedded colon paraffin fixed Formalin Formalin fixed paraffin embedded human breast carcinoma stained with CA 15-3 (Mob134-1). embedded human breast carcinoma paraffin fixed Formalin Page 12-16 Hard Edit.pdf 4 Page 12-16 Hard Edit.pdf 5 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumancolon carcinoma stainedwithCA125(RMAB061). Formalin fixed paraffin embeddedovarian cancer stainedwithCA125antibody(Mob110). to the peritoneum. binding of CA125 to mesothelin may contribute to ovarian cancer metastasizing mesothelioma. The on expressed and mesothelin to binds also CA125 addition, carcinomaendometrial carcinoma, andclearcellcarcinoma cervix ofbladder. In xrse o oain acnm ad eea eihla tmr including tumors epithelial several and carcinoma ovarian on expressed A15 125 CA Anti-Human Monoclonal Rabbit 125 CA Monoclonal MouseAnti-Human nie. t s haiy lcsltd ui ecdd y U1 gn. t is It gene. MUC16 by encoded mucin glycosylated heavily a is It antigen. Specificity: Cellular Localization: Positive Control: Isotype: protein. Immunogen: RMPD061Prediluted 6ml Status:Regulatory IVD Catalog No.: RMAB061 Concentrated 0.5ml Clone: such as seminal vesicle and anaplastic lymphomas. ovarian for marker tumor epithelial malignancies.useful However,a CA is 125 has been 125 described in CA other neoplasms that shown have studies Several Specificity: Cellular Localization: Positive Control: Isotype: tissues of patients with epithelial ovarian cancer. Immunogen: Mob110-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob110Concentrated 1ml Clone: ------EP48 OV185:1 Rabbit Rabbit IgG IgG1 This antibody reacts specifically with CA 125 ovarian cancer antigen. Carcinoma antigen 125 (CA125) is a high molecular weight tumor weight molecular high a is (CA125) 125 antigen Carcinoma A synthetic peptide corresponding to residues in human CA125 human in residues to corresponding peptide synthetic A atal prfe hmn ui fato fo a ol f cancer of pool a from fraction mucin human purified Partially Ovarian Ovarian carcinoma Ovarian carcinoma Membrane/Cytoplasm Extracellular membrane F F ,/ ,/ P P H H 16 Formalin fixed paraffin embeddedhumanrenalcell carcinoma stainedwithPan-Cadherin (RP133). Formalin fixed paraffin embeddedhumanrenalcell carcinoma stainedwithPan-Cadherin (Mob228). catenins, which in turn bind to α catenin. Cadherins play an important role in tumor role invasion important and an metastas. play Cadherins catenin. α to bind turn in which catenins, adhesion. and development of cells. In adhesion junctions, cadherins are bound to β and γ dependent celladhesionmolecules, role whichplay inthegrowth animportant Specificity: Cellular Localization: Positive Control: Immunogen: RP133-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: RP133Concentrated 1ml ige hi gyorti rcpos eitn C2 dpnet cell-cell dependent Ca2+ mediating receptors glycoprotein chain single of family multigene a of members are Cadherins tissues. of variety wide a from Specificity: Cellular Localization: Positive Control: Isotype: chicken N-cadherin with extra N-terminal lysine residue. Immunogen: Mob228-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob228Concentrated 1ml Clone: Cadherin, Pan Monoclonal MouseAnti-Human ahrn a Cadherin, Pan Polyclonal Anti-Human Rabbit ------CH-19 IgG1 This antibody reacts with 120 kDa protein. Cadherins are calcium This antibody reacts with pan cadherin with a distinct 135 kDa band A synthetic peptide from the C-terminus of chicken N-cadherin. Synthetic peptide corresponding to the C-terminal amino acids of Tonsil Tonsil Cell membrane Cell membrane F F ,/ ,/ P P E H 2/17/17 5:11PM Primary Antibodies 2/17/17 5:00 PM www.dbiosys.com H H P P ,/ ,/ F F 3 6 0 3 6 0 Cytoplasmic Cytoplasmic Thyroid or medullary carcinoma medullary or Thyroid Endometrial cancer Endometrial BALB/C mice were injected with human uterus smooth muscle Synthetic human calcitonin 1-32 amino acid peptide. acid amino 1-32 calcitonin human Synthetic This antibody is specific to high molecular weight (120-150 kDa) h- This antibody recognizes calcitonin, a 32 amino acid peptide, which calcitonin, a 32 amino acid peptide, This antibody recognizes IgG IgG1 SP17 hHCD ------Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: can be demonstrated in C cells of the normal and Staining hyperplastic thyroid. for calcitonin may be used for the identification of a spectrum of C cell Monoclonal Mouse Anti-Human Caldesmon Monoclonal RabbitMonoclonal Anti-Human Calcitonin Calcitonin Immunogen: Clone: 1ml Mob316-2 Concentrated No.: Catalog 0.5ml Mob316-2-05 Concentrated 6ml PDM223 Prediluted 10ml PDM223-10MM Prediluted Clone: 0.5ml Concentrated RMAB009 No.: Catalog IVD Regulatory Status: 6ml RMPD009 Prediluted 10ml RMPD009-10RM Prediluted proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid granular pattern produces in the cytoplasm. Amyloid deposits a within the tumor may also fine activity. calcitonin of degrees varying exhibit Regulatory Status: IVD Regulatory Status: extract. Isotype: Control: Positive Localization: Cellular Specificity: caldesmon. Caldesmon is involved in smooth muscle and non-muscle contraction. contraction. Two closely related variants of human caldesmon have been identified. cells. The and tissue non-muscle h-caldesmon in found is kD) variant (71-80 l-caldesmon whereas is muscle, predominantly expressed in smooth Formalin fixed paraffin embedded endometrial cancer stained with Caldesmon antibody (Mob316-2). embedded endometrial cancer paraffin fixed Formalin Formalin fixed paraffin embedded human thyroid medullary carcinoma stained with Calcitonin embedded human thyroid medullary carcinoma paraffin fixed Formalin antibody (RMAB009). 17 E H P P , ,// F F 3 6 0 Cytoplasmic Cytoplasmic, cell membrane cell Cytoplasmic, Thyroid Kidney Synthetic Synthetic peptide of human calcitonin corresponding to amino Purified bovine kidney calbindin-D-28K. kidney bovine Purified This antibody stains C cells of the thyroid. Staining for calcitonin may may calcitonin for Staining thyroid. the of cells C stains antibody This This antibody is specific to a protein of 28 kDa. Calbindin-D-28K is also is Calbindin-D-28K kDa. 28 of protein a to specific is antibody This IgG1 CB-955 ------Immunogen: 1-32. acids Control: Positive Localization: Cellular Specificity: Regulatory Status: IVD Regulatory Status: Polyclonal Rabbit Anti-Human Polyclonal Calcitonin 1ml RP050 Concentrated No.: Catalog 6ml PDR024 Prediluted 10ml PDR024-10RP Prediluted 0.5ml RP050-05 Concentrated Positive Control: Control: Positive Localization: Cellular Specificity: Immunogen: Isotype: Monoclonal Mouse Anti-Human Monoclonal Calbindin-D-28K Clone: 1ml Mob 295-1 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob 295-1-05 Concentrated be used for the identification of a spectrum of C cell abnormalities proliferative tumors. invasive to hyperplasia cell C from ranging known as vitamin D-dependent calcium-binding protein or cholecalcin. Calbindin D-28K has a broad tissue distribution; however it exhibits a cell type- specific expression pattern. This antibody reacts specifically with calbindin-D-28K with specifically reacts antibody This pattern. expression specific tissues. kidney and brain in Formalin fixed paraffin embedded human thyroid stained with Calcitonin antibody (PDR024). paraffin fixed Formalin Formalin fixed paraffin embedded human kidney stained with Calbindin antibody (Mob295-1). paraffin fixed Formalin Page 17-26 Hard Edit.pdf 1 Page 17-26HardEdit.pdf 2 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanuterusstainedwithCalponin(Mob345). Formalin fixed paraffin embeddedendometrialcarcinoma stainedwithCaldesmon,HMW(RMAB089). and non-muscle muscle. contraction. skeletal in muscle detected smooth in involved protein been regulated developmentally a has is Caldesmon variants two the of Neither cells. and cellular in smooth muscle and whereas l-caldesmon (70-80 kDa) mobility is found in non-muscle tissue electrophoretic their distribution. variant(120-150kDa)ispredominantlyThe h-caldesmon expressed in different are which identified s etitd o moh uce el. w ioom o cloi eit whose the exist muscle of the calponin urogenital tract. of isoforms Two cells. molecular weights are muscle 34 kDa and 29 kDa. smooth 29 kDa isoform to is primarily restricted to restricted is be to thought is involved in the regulation of smooth muscle and contraction. Expression of calponin F-actin and tropomyosin binds calmodulin, a Calponin, Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: Mob345-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob345Concentrated 1ml Clone: Calponin Monoclonal MouseAnti-Human Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: RMPD089-10RMPrediulted 10ml RMPD089Prediulted 6ml RMAB089-1 Concentrated 1ml Status: Regulatory IVD Catalog No.: RMAB089 Concentrated 0.5ml Clone: Caldesmon, HMW(h-Caldesmon) Anti-Human Monoclonal Rabbit ------CALP (sameashCP) DBR16.2 IgG1 Rabbit IgG hs nioy ecs ih 3 ka rti kon s calponin. as known protein kDa 34 a with reacts antibody This w coey eae vrat o hmn adso hv been have caldesmon human of variants related closely Two BALB/C mice were injected with crude human uterus extract. Recombinant human CALD1 protein fragment. Breast Endometrial carcinoma Cytoplasmic Cytoplasmic 3 60 F F ,/ ,/ P P E E NEW 18 Formalin fixed paraffin embeddedhumanuterusstainedwithCalponin-1(RMAB093). Formalin fixed paraffin embeddedhumanmesotheliomastainedwithCalretininantibody(PDR044). pulmonary pulmonary adenocarcinomas. some and mesotheliomas in detected been has and superfamily C troponin the from humans. Calretinin is an intracellular calcium-binding protein belonging originating to tissue in calretinin with specifically reacts antibody This calretinin. Specificity: Cellular Localization: Positive Control: Immunogen: PDR044Prediluted 6ml RP043-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: RP043Concentrated 1ml apnn1 RMPD093-10RMPrediulted 10ml RMPD093Prediulted 6ml RMAB093-1 Concentrated 1ml Catalog No.: RMAB093 Concentrated 0.5ml Clone: Calponin-1 Anti-Human Monoclonal Rabbit artnn Calretinin Polyclonal Anti-Human Rabbit (contractile) phenotype differentiated of the developing of smooth marker muscle.a be to the shown been has in and cells muscle involved smooth to be restricted is to expression Calponin contraction. thought muscle smooth is of regulation which protein, binding tropomyosin and fibroblast extracts of cultivated human foreskin. Calponin is a calmodulin, F-actin calponin in extracts of human aortic medial smooth muscle and is unreactive with Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: Status:Regulatory IVD ------DBR16.8 Rabbit Rabbit IgG The antibody is specific against a calcium binding protein called In Western blotting, this Mab reacts with only the 34kDa form of form 34kDa the only with reacts Mab this blotting, Western In Recombinant full length mouse calretinin protein. Recombinant human CNN1 protein. Mesothelioma Uterus Cytoplasmic Cytoplasmic 3 60 F F , ,/ P P H NEW 2/17/17 5:00PM Primary Antibodies 2/17/17 5:00 PM www.dbiosys.com P P , , F F 3 6 0 3 6 0 Cytoplasmic and lumenal membrane lumenal and Cytoplasmic Cytoplasmic, lumenal membrane lumenal Cytoplasmic, Colon carcinoma Colon Colon carcinoma Colon Human CEA isolated from hepatic metastasis of colon BALB/C mice were injected with extract of colon carcinoma cells. carcinoma colon of extract with injected were mice BALB/C This antibody reacts with CEA and CEA-like NCA, e.g. protein, NCA2 This antibody is a member of a family of complex antigens which also which antigens complex of family a of member a is antibody This IgG2a, kappa IgG2a, COL-1 ------Monoclonal Mouse Anti-Human (CEA) Antigen Carcinoembryonic Clone: 1ml Mob008 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob008-05 Concentrated 6ml PDM005 Prediluted 10ml PDM005-10MM Prediluted Polyclonal Rabbit Anti-Human Polyclonal Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: specific stains antibody This (NCA). antigens cross-reacting non-specific includes any show not does but adenocarcinomas colorectal with reacts It CEA. of regions erythrocytes. and neutrophils polymorphonuclear with staining Carcinoembryonic Antigen (CEA) (CEA) Antigen Carcinoembryonic RP003 Concentrated 1ml RP003 Concentrated No.: Catalog 0.5ml RP003-05 Concentrated 6ml PDR025 Prediluted 10ml PDR025-10RP Prediluted Immunogen: Regulatory Status: IVD Regulatory Status: adenocarcinoma. Control: Positive Localization: Cellular Specificity: and spleen BGP1. and Inliver, lung, colon breast, in adenocarcinoma, staining this positive shows antibody antibody stains The the enterocytes. luminal part of tissues. Formalin fixed paraffin embedded human colon carcinoma stained with CEA (Mob008). carcinoma embedded human colon paraffin fixed Formalin Formalin fixed paraffin embeded human colon adenocarcinoma stained with CEA antibody adenocarcinoma embeded human colon paraffin fixed Formalin (RP003). 19 H H P P ,/ ,/ F F 3 6 0 3 6 0 Cytoplasmic Cytoplasmic Mesothelioma Lung, colon, prostate and breast tissue. breast and prostate colon, Lung, Anti-Cytokeratin, Anti-Cytokeratin, clone CAM 5.2, is derived from hybridization of Recombinant full-length mouse calretinin protein. calretinin mouse full-length Recombinant This antibody recognizes a 31.5 kDa protein named calretinin. Anti-Cytokeratin Anti-Cytokeratin (CAM 5.2) reagent has a primary reactivity with IgG2a IgG CAM 5.2 SP13 ------Immunogen: mouse mouse P3/NS-1/1-Ag4-1myeloma cells with spleen cells from BALB/c mice Monoclonal Mouse Anti-Human CAM 5.2 Clone: 1ml Mob469 Concentrated No.: Catalog IVD Regulatory Status: 0.5 ml Mob469-05 Concentrated 6ml PDM181 Prediluted 10ml PDM181-10MM Prediluted Cellular Localization: Localization: Cellular Specificity: C troponin the to belonging protein calcium-binding intracellular an is Calretinin superfamily and is characterized by a structural motif described as the EF-hand domain. The immunohistochemical detection of calretinin in developing Isotype: Control: Positive Immunogen: Monoclonal RabbitMonoclonal Anti-Human Calretinin Clone: 0.5ml Concentrated RMAB010 No.: Catalog 6ml RMPD010 Prediluted 10ml RMPD010-10RM Prediluted Regulatory Status: IVD Regulatory Status: Positive Control: Control: Positive Localization: Cellular Specificity: 48 and peptides #7 and #8, Mr to Moll’s that correspond human keratin proteins of epithelia secretory on present are 8 and 7 Cytokeratin respectively. (kd), kDa 52 Anti-Cytokeratin epithelium. squamous onstratified not but tissue human normal (CAM 5.2) stains most epithelial-derived tissue, 5.2) (CAM Anti-Cytokeratin carcinomas. cell including: renal and hepatocellular epithelium, liver, renal tubular carcinomas. cell squamous some with react not might immunized with the human colorectal carcinoma cell line HT29. line cell carcinoma colorectal human the with immunized Isotype: cerebellum is restricted to the later stages indicated by weak staining from week week from staining weak by indicated stages later the to restricted is cerebellum nucleus. dentate the of neurons in and cells basket and Purkinje in gestation of 21 The intensity of staining increases as the cerebellum matures. In tumors, calretinin calretinin has been detected in mesotheliomas and some pulmonary adenocarcinomas. Formalin fixed paraffin embedded human mesothelioma stained with Calretinin antibody (RMAB010). paraffin fixed Formalin Formalin fixed Paraffin embedded human breast tissue stained with CAM 5.2 (Mob469). Paraffin fixed Formalin Page 17-26 Hard Edit.pdf 3 Polyclonal Rabbit Anti-Human Polyclonal Rabbit Anti-Human Caspase 1/ Interleukin-1-β Converting Enzyme F,/ P H Caspase 3/CPP32 F,/ P H Catalog No.: RP064 Concentrated 1ml Catalog No.: RP096 Concentrated 1ml RP064-05 Concentrated 0.5ml RP096-05 Concentrated 0.5ml
Regulatory Status: IVD (Only for markets outside the U.S. For U.S. market, RUO.) Regulatory Status: IVD (Only for markets outside the U.S. For U.S. market, see index III.)
Formalin fixed paraffin embedded human placenta stained with Caspase 1 antibody (RP064). Formalin fixed paraffin embedded human colon adenocarcinoma stained with Caspase 3/CPP32 (RP096). Immunogen: A synthetic peptide from the second quarter of human Caspase 1 protein. Immunogen: Recombinant full-length human caspase 3 protein. Positive Control: Placenta Positive Control: Tonsil Cellular Localization: Nuclear, cell membrane Cellular Localization: Cytoplasmic, some nuclear Specificity: This antibody reacts with a 45 kDa protein, caspase 1, and is Specificity: This antibody reacts with a 32 kDa protein. Caspase 3 is a member of expressed as a proenzyme in many tissues. Active Caspase 1 is a tetramer two the interleukin-1 β-converting enzyme family. Caspase 3 is a member of the subunits p10, and p20, in 2:2 ratio. Overexpression of caspase 1 can induce interleukin-1β-converting enzyme family and is thought to be associated with apoptosis in fibroblast, which can be inhibited by overexpression of Crm A, a induction of apoptosis. Caspase 3 is synthesized as inactive 32 kDa proenzyme protein from pox virus. and is processed during apoptosis generating two subunits of 17 kDa and 12 kDa. Caspase 3 stains the epithelial cells of skin, renal proximal tubules and collecting ------ducts. ------Monoclonal Mouse Anti-Human Caspase 3 F,/ P H Polyclonal Rabbit Anti-Human Clone: 3CSP03 Caspase 8/FLICE F,/ P H Catalog No.: Mob309 Concentrated 1ml Catalog No.: RP097 Concentrated 1ml Mob309-05 Concentrated 0.5ml RP097-05 Concentrated 0.5ml Primary Antibodies
Regulatory Status: IVD (Only for markets outside the U.S. For U.S. market, see index III.) Regulatory Status: IVD (Only for markets outside the U.S. For U.S. market, see index III.)
Formalin fixed paraffin embedded human tonsil stained with Caspase 3 antibody (Mob309). Formalin fixed paraffin embedded human stomach stained with Caspase 8 antibody (RP097). Immunogen: BALB/C mice were injected with recombinant full length human Immunogen: Recombinant full-length human caspase 8 protein. caspase 3 protein. Positive Control: Stomach Isotype: IgG2a Cellular Localization: Cytoplasmic Positive Control: Tonsil Specificity: This antibody reacts with a 55 kDa protein. Caspase 8 has an N- Cellular Localization: Cytoplasmic terminal domain with sequence homology to the death effector domain (DED) of Specificity: This antibody is specific to a 32 kDa protein. Caspase 3 is associated FADD. Caspase 8 binds to DED of FADD. Caspase 8 is activated by association with with induction of apoptosis. Caspase 3 is ubiquitously expressed and is Fas/FADD death-inducing signaling complex to release two active subunits, p18 synthesized as an inactive proenzyme. and p10, into the cytosol, where they activate other caspases, amplifying the apoptotic signal.
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Page 17-26 Hard Edit.pdf 4 2/17/17 5:00 PM Primary Antibodies 2/17/17 5:00 PM www.dbiosys.com P P 3 0 3 0 rediluted 10ml rediluted rediluted 10ml rediluted oncentrated 0.5ml oncentrated 0.5ml ediluted ml ediluted ml oncentrated 1ml r r Cell membrane, cytoplasm membrane, Cell Cytoplasmic oncentrated 1ml Tonsil Breast carcinoma, prostate carcinoma, Breast BAB/C Āmice were injected with thymus cells. thymus with injected were BAB/C Āmice Cathepsin D isolated from human liver. human from isolated D Cathepsin Mob3 3-05 C PDM1 3 P RP00 -05 C PDR00 P PDM1 3-10MM P PDR00 -10RP P PDR00 -10RP This antibody reacts with the zymogen as well as the activated form form activated the as well zymogenas the with reacts antibody This This antibody reacts with a 9 ĀkDa protein. At least five CD1 genes are are genes CD1 five least At protein. 9 ĀkDa a with reacts antibody This IgG1, kappa IgG1, 10 ------Clone: Mob3 3 C o : Catalo I uno en: Isotype: Control: Positive Localization: Cellular Specificity: Catalo o : RP00 C o : Catalo Itof cathepsin D. stains fibroblasts and macrophages strongly but stains weakly ducts and glands in the Itsweat stains the cells of breast. with the myoepithelial acini. pancreatic of granules and cells, islets skin, I e ulatory Status: I uno en: Control: Positive Localization: Cellular Specificity: e ulatory Status: I e ulatory Status: C a Monoclonal Mouse Anti-Human Polyclonal Rabbit Anti-Human Polyclonal Cat epsin identified (CD1a, b, c, d, and e). This antibody reacts with cortical thymocytes, in of epidermis, dendritic cells of dermis, and angerhans Ācells angerhans Ācells leukemias of characterization the in useful be may antibody This tonsil. of mucosa lymphomas. and Formalin fixed paraffin embedded human tonsil stained with CD1a antibody (Mob363). paraffin fixed Formalin Formalin fixed paraffin embedded human prostate stained with Cathepsin D antibody (RP004). paraffin fixed Formalin 21 NEW β (RP080). β (PDM264). P P 3 0 Cytoplasmic, cell membrane cell Cytoplasmic, Breast carcinoma, large intestine large carcinoma, Breast Recombinant human beta-Catenin (p120) protein fragment. protein (p120) beta-Catenin human Recombinant A synthetic peptide derived from the C-terminus of human of C-terminus the from derived peptide synthetic A This antibody reacts with a 92 kDa protein knownThe as β-catenin. In normal tissues, beta-catenin is localized to the membrane of IgG1,kappa DBM15.55 ------Polyclonal Rabbit Anti-Human Polyclonal Catenin Isotype: I uno en: carcinoma Breast Control: Positive Cell urface and Cytoplasmic Localization: Cellular Specificity: epithelial cells, consistent with its role in the cell adhesion complex. In ductal breast neoplasia, beta-catenin is usually localized in cellular membranes. catenins (α, β and γ) are ubiquitously expressed cytoplasmic proteins, which are which are cytoplasmic ubiquitously expressed proteins, catenins (α, β and γ) are associated with E-cadherin. β-catenin can also bind to APC. Cadherin/catenin complexes are linked to the cytoskeleton via a α-catenin. direct and actinin association between α- Cellular Localization: Localization: Cellular Specificity: Monoclonal Mouse Anti-Human Catenin Clone: 1ml Mob529 Concentrated o : Catalo I e ulatory Status: PDM2 Prediluted ml 10ml PDM2 -10MM Prediluted β-catenin protein. β-catenin Control: Positive I uno en: RP080 Concentrated 1ml RP080 Concentrated o : Catalo I e ulatory Status: 0.5ml RP080-05 Concentrated However, However, in lobular neoplasia, a marked redistribution of beta-catenin throughout throughout the cytoplasm results in a diffuse staining cytoplasmic of beta-catenin pattern. and E-cadherin Immune- helps in the accurate identification ductal of low-grade between distinction a including neoplasms, lobular and ductal carcinoma in sito (DCI) Āand lobular carcinoma. Additionally, some rectal staining beta-catenin cytoplasmic and diffuse demonstrate adenocarcinomas gastric and a lack of membranous staining, mimicking the staining carcinomas. pattern breast observed lobular with Formalin fixed paraffin embedded human lung carcinoma stained with Catenin, embedded human lung carcinoma paraffin fixed Formalin Formalin fixed paraffin embedded large intestine stained with Catenin, paraffin fixed Formalin Page 17-26 Hard Edit.pdf 5 Page 17-26HardEdit.pdf 6 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithCD1aantibody(RMAB062). Formalin fixed paraffin embeddedhumantonsilstainedwithCD1a/HTA1 (RMAB098). h lmh oe At-Da s eotd o e nw akr o perivascular for marker new a be epithelial cell to tumor (PEComa). reported is Anti-CD1a node. lymph the lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of angerhans cell ( CH), histiocytosis extranodal histiocytic sarcoma, a subset of T- RMPD098-10RM Prediluted 10ml RMPD098 Prediluted ml RMAB098-1 Concentrated 1ml Status: e ulatory I Catalog No.: RMAB098 Concentrated 0.5ml Clone: lymphoma/leukemia. identify thymocytes, cortical presenting them to T-cell receptors on natural killer T-cells. CD1a antibody labels beta-2-microglobulin. CD1a binds self and non-self lipid and glycolipid antigens, histocompatibility complex (MHC) antigen-like glycoproteins that associate with Specificity: Cellular Localization: Positive Control: Isotype: protein. I uno en: RM Status: e ulatory I Catalo o : RM Clone: C1 i a akr for marker a is CD1a , pecifically cells. dendritic some and subset cell B with β-2-Microglobulin and expressed on cortical thymocytes, angerhanscells, a associated are antigens CD1 molecules. MHC-like antigen-presentingglycolipid a C a Anti-Human Monoclonal Rabbit C a Anti-Human Monoclonal Rabbit Specificity: Cellular Localization: Positive Control: Isotype: I uno en: ------DBR1 .13 EP80 Rabbit Rabbit IgG1 Rabbit Rabbit IgG anger kDa transmembrane glycoprotein in the CD1 family of family CD1 the glycoproteinin transmembrane a 9kDa is CD1a RMPD0 2P lse o Dfeetain a C1) s at f fml o major of family a of part is (CD1a) 1a Differentiation of Cluster Recombinant human CD1a protein. snhtc etd crepnig o eius n ua CD1a human in residues to corresponding peptide synthetic A AB0 2-1 C AB0 2 C hans Thymus, tonsil Tonsil angerhans Membrane Cell membrane el itoyoi ad rcro lymphoblastic T precursor and histiocytosis cell r oncentrated 0.5ml ediluted ml oncentrated 1ml . cells and dendritic cells. It has been used to used been has It cells. dendritic and cells . 3 0 P P NEW 22 Formalin fixed paraffin embeddedhumantonsilstainedwithCD3antibody(Mob422). Formalin fixed paraffin embeddedhumantonsilstainedwithCD3(RMAB005). T cells and related neoplasms. constituent. This antibody labels CD3ε and is a useful tool for the identification of cortical thymocytes, the antigen is predominantly present as an intracytoplasmic probably represents oneoftheearliestsignscommitmentto T celllineage. In ise.Ti atbd i sial fr tiig oml n nolsi cls in cells T neoplastic formalin-fixed, and paraffin-embedded tissues. normal staining for suitable is antibody This tissues. T cells in both the cortex and medulla of the thymus and in peripheral lymphoid intracytoplasmic portion of the CD3 antigen expressed by T cells. It stains human the with reacts antibody This tissues. neoplastic and normal in expression CD3 detect help will antibody marker.This cell pan-T a as regarded generally is and Specificity: Cellular Localization: Positive Control: Isotype: chain of human CD3 protein. Monoclonal Rabbit Anti-Human Monoclonal Rabbit Specificity: Cellular Localization: Positive Control: Isotype: I uno en: Status: e ulatory I Catalo o : Mob 22C Clone: C Cell Monoclonal MouseAnti-Human C I uno en: RMPD005-10RMPrediluted 10ml RMPD005Prediluted ml RMAB005-1 Concentrated 1ml Status: e ulatory I Catalo o : RMAB005 Concentrated 0.5ml Clone: ------ .2.38 P IgG IgG1 The CD3 antigen is present on early thymocytes and mature T cells mature T and thymocytes early on present is antigen CD3 The Mob 22-05C D i frt eetbe n al tyoye ad t appearance its and thymocytes early in detectable first is CD3 Purified of the ε the aa 15 -1 8of to corresponding peptide 13-mer synthetic A Tonsil Tonsil CD3εγδ/CD3 Cell membrane Membrane and cytoplasmic oncentrated 1ml oncentrated 0.5ml . 3 0 P P 2/17/17 5:00PM Primary Antibodies 2/17/17 5:00 PM of the ε www.dbiosys.com 15 -1 8 of the human CD3 ζ CD3 human the of 3 5 3 P P oncentrated 0.5ml oncentrated 0.5ml oncentrated 0.5ml Cell membrane Cell Cell membrane Cell oncentrated 1ml oncentrated 1ml Tonsil Tonsil A synthetic 13-mer peptide corresponding to aa A synthetic peptide corresponding to aa to corresponding peptide synthetic A This antibody reacts with a 19 kDa protein. CD3 consists of five RP11 -05 C RP11 -05 C This antibody reacts with a 20 kDa protein. This antibody reacts with reacts antibody This protein. kDa 20 a with reacts antibody This ------protein. Control: Positive Localization: Cellular Specificity: of heterodimer a dimers: three form to associate that chains polypeptide invariant chains ζ two of homodimer a and chains, ε and δ of heterodimer a chains, ε and γ of copies consecutive three of consists chain ζ chains. η and ζ of heterodimer a or motif. same the I uno en: Catalo o : RP11 C o : Catalo I e ulatory Status: I uno en: Catalo o : RP11 C o : Catalo I e ulatory Status: Rabbit Anti-Human Polyclonal C Polyclonal Rabbit Anti-Human Polyclonal ar er Cell C arly chain of human CD3 protein. CD3 human of chain Control: Positive Localization: Cellular Specificity: intracytoplasmic portion of the CD3 antigen expressed by T cells. It stains human stains It cells. T by expressed antigen CD3 the of portion intracytoplasmic lymphoid peripheral in and thymus the of medulla and cortexthe both in cells T tissues. (RP117) (RP116) 23 P P 3 0 rediluted ml Ārediluted ediluted ml oncentrated 0.5ml r Cell membrane Cell Cell Membrane Cell Tonsil Tonsil, lymphoma Tonsil, AB0 8 C A synthetic peptide corresponding to residues in cytoplasmic . ynthetic human CD3 polypeptide conjugated to bovine serum This antibody reacts with intracytoplasmic portion of the CD3 CD3 (Cluster of Differentiation 3) is a complex of proteins that RMPD0 8 P RMPD0 8-10RM P RMPD0 8-10RM Rabbit IgG Rabbit EP 1 ------I uno en: albumin. Control: Positive Localization: Cellular and thymus the of medulla as Specificity: well as cortex in cells T stains It cells. T the on antigen Positive Control: Control: Positive Localization: Cellular Specificity: five of composed is CD3 (TCR). receptor antigen cell T the with directly associates invariant polypeptide chains that associate to form three dimers. The five domain of human CD3 epsilon protein. epsilon CD3 human of domain Isotype: I uno en: Polyclonal Rabbit Anti-Human Polyclonal Monoclonal RabbitMonoclonal Anti-Human Cell C C Cell Cell C lymphoid tissues. This antibody also labels T cell neoplasm, malignant histiocytes malignant neoplasm, cell T labels also antibody This tissues. lymphoid lymphoma. Hodgkin in cells Reed- ternberg and invariant chains of CD3 are labeled gamma, delta, epsilon, zeta, and eta. The CD3 The eta. and zeta, epsilon, delta, gamma, labeled are CD3 of chains invariant Thymus, in cells T on expressed is It survival. and development cell T in involved is 1ml RP005 Concentrated o : Catalo I e ulatory Status: 0.5ml RP005-05 Concentrated ediluted ml PDR002 Pr
e ulatory Status: I e ulatory Status: Clone: RM o : Catalo peripheral lymphoid tissue, malignancies. blood and derived bone cell marrow. CD3 T is a and commonly cell used T of identification for marker (P R ) (R ) Page 17-26 Hard Edit.pdf 7 Page 17-26HardEdit.pdf 8 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithCD4(RMAB083). Formalin fixed paraffin embeddedhumantonsilstainedwithCD3e(Mob525). n h casfcto o lmhcts n nlmaoy ein ad malignant and legions inflammatory in lymphomas. lymphocytes of classification the in role NK/T-cell extranodal playsand important CD4 leukemia NK-cell lymphoma. Most mature T-cell lymphomas are cells. CD4 antigen-presentingpositive with of the exception surface of aggressivethe of molecules II class MHC with directly interacts also and cell antigen-presenting with (TCR) receptor T-cell the assists that co-receptor is It cells. dendritic and macrophages, monocytes, cells, helper Specificity: Cellular Localization: Positive Control: Isotype: protein Immunogen: Immunogen: CD4 Anti-Human Monoclonal Rabbit specific highly a is antigen marker CD3 for surface. T cells, cell and T is the present in on majority of appears medullary T it cell in neoplasms.thymocytes, However, intra-cytoplasmic. predominantly is CD3 thymocytes, represents one of the earliest signs of commitment to the T cell lineage. In corticol Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: PDM260-10MMPrediluted 10ml PDM260Prediluted 6ml Status:Regulatory IVD Catalog No.: Mob525Concentrated 1ml Clone: CD3e Monoclonal MouseAnti-Human RMPD083-10RMPrediluted 10ml RMPD083Prediluted 6ml RMAB083-1 Concentrated 1ml Status:Regulatory IVD Catalog No.: RMAB083 Concentrated 0.5ml Clone: ------DBM15.51 EP204 IgG IgG, kappa The CD3 antigen is first detectable in early thymocytes and probably CD4 is glycoprotein found on the surface of immune cells such as such T cells immune of surface the glycoproteinon foundis CD4 A recombinant fragment specific to human Cd3e ytei ppie orsodn t rsde o hmn CD4 human of residues to corresponding peptide Synthetic Tonsil Tonsil Cell membrane Cell surface and cytoplasmic 3 60 3 60 F F ,/ ,/ P P H H NEW NEW 24 Formalin fixed paraffin embeddedhumantonsilstainedwithCD4(Mob119). Formalin fixed paraffin embeddedhumantonsilstained withCD5antibody(Mob138). monocytes. s on o a cl sbe (epridcr ad lo n hmcts and thymocytes on also and (helper/inducer) subset cell T a on found is transmembrane glycoprotein with a molecular weight of 59 kDa. The CD4 antigen Specificity: Cellular Localization: Positive Control: Isotype: molecule. Immunogen: PDM093Prediluted 6ml Mob119-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob119Concentrated 1ml Clone: CD4 Monoclonal MouseAnti-Human ciae cls hs nioy a b ue fr h dtcin fT el acute cell T of detection the lymphocytic for leukemias. used be can antibody This cells. T activated peripheral of blood lymphocytes. CD5 is 72% expressed by many and T cell thymocytes leukemias, lymphomas, and of 95% on present kDa 67 of glycoprotein Specificity: Cellular Localization: Positive Control: Isotype: external domain of the CD5 molecule. Immunogen: PDM095-10MMPrediluted 10ml PDM095Prediluted 6ml Mob138-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob138Concentrated 1ml Clone: CD5 Monoclonal MouseAnti-Human ------1F6 4C7 IgG1 IgG1, kappa This antibody reacts specifically with CD4 cells. CD4 is a single chain This antibody is specific to CD5 antigen. It stains a cell surface surface cell a stains It antigen. CD5 to specific is antibody This Synthetic peptide corresponding to the external domain of CD4 of domain external the to corresponding peptide Synthetic eobnn poaytc uin rti crepnig o the to corresponding protein fusion prokaryotic Recombinant Tonsil Tonsil Cell membrane Cell membrane 3 60 F F ,/ ,/ P P H H 2/17/17 5:00PM Primary Antibodies 2/17/17 5:00 PM www.dbiosys.com P P 3 0 3 0 rediluted 10ml rediluted oncentrated 0.5ml ediluted ml oncentrated 1ml r Cell membrane Cell Cell membrane Cell Tonsil Tonsil ynthetic peptide comprised of 13 C terminal amino acids from the from acids amino terminal C 13 of comprised peptide ynthetic ynthetic peptide sequence comprising the 13 C-terminal amino Mob11 -05 C PDM09 P PDM09 -10MM P This antibody reacts specifically with a 32 kDa protein similar to the This antibody recognizes the CD8. The CD8 molecule consists of two two of consists molecule CD8 The CD8. the recognizes antibody This IgG P1 1 B ------I uno en: chain. α CD8 the of domain cytoplasmic the of acids Isotype: Control: Positive Localization: Cellular Specificity: as or heterodimer α/β disulphide-linked a as expressed are which β, and α chains, an α/α homodimer on T cell subset, thymocytes, and NK cells. The majority of CD8+ T cells express CD8 as α/β CD8 heterodimer. functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 Clone: 0.5ml Concentrated RMAB012 o : Catalo I e ulatory Status: ediluted ml RMPD012 Pr 10ml RMPD012-10RM Prediluted C Monoclonal Mouse Anti-Human Cell C Clone: Mob11 C o : Catalo
Monoclonal RabbitMonoclonal Anti-Human I uno en: e ulatory Status: I e ulatory Status: envelope glycoprotein binds CD8 α chain (but not β chain). β not (but chain α CD8 binds glycoprotein envelope cytoplasmic domain of the CD8 molecule. CD8 the of domain cytoplasmic kappa IgG1, Isotype: Control: Positive Localization: Cellular Specificity: CD8 molecule. This antibodies. monoclonal antibody CD8 clustered to stains similar patterns staining cytotoxic/suppressor T cells and shows Formalin fixed paraffin embedded human tonsil stained with CD8 T-Cell antibody (PDM094). embedded human tonsil stained with CD8 T-Cell paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with CD8 antibody (RMPD012). paraffin fixed Formalin 25 P P 3 0 Cell membrane Cell Cell membrane Cell Tonsil A synthetic peptide sequence comprising the 13 C-terminal amino C-terminal 13 the comprising sequence peptide synthetic A . ynthetic peptide from the intracellular region of Cd5. of region intracellular .the from peptide ynthetic This antibody recognizes CD5, which is a transmembrane protein, The CD8 molecule is composed of two chains: α and β. CD8 is found found is CD8 β. and α chains: two of composed is molecule CD8 The IgG P19 ------acids of the cytoplasmic domain of the CD8 α chain. α CD8 the of domain cytoplasmic the of acids Control: Positive Localization: Cellular Specificity: I uno en: Polyclonal Rabbit Anti-Human Polyclonal C Monoclonal RabbitMonoclonal Anti-Human C Tonsil Control: Positive Localization: Cellular Specificity: In lymphocytes. blood peripheral and 2% of thymocytes 95%of on found is and the main reactivity CD5 is expressedlymph nodes, by T cell areas. is observed in many T cell leukemias, lymphomas, and Mantle cell lymphomas (same as on a subset of B cells. antigen is also expressed activated T cells. ccasionally, CD5 diffuse centrocytic lymphomas) are CD5(+) while the follicle center cell Isotype: I uno en: Clone: 0.5ml Concentrated RMAB011 o : Catalo ediluted ml RMPD011 Pr 10ml RMPD011-10RM Prediluted on a T cell subset of normal cytotoxic/suppressor cells which make up RP100 Concentrated 1ml RP100 Concentrated o : Catalo I e ulatory Status: 0.5ml RP100-05 Concentrated e ulatory Status: I e ulatory Status: lymphoma are CD5(-). are lymphoma approximately approximately 20 to 35 % of human peripheral blood antigen lymphocytes. The is CD8 also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells, cells. marrow and 15 to 30% of bone Formalin fixed paraffin embedded human tonsil stained with CD8 antibody (RP100). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with CD5 antibody (RMAB011). paraffin fixed Formalin Page 17-26 Hard Edit.pdf 9 Page 17-26HardEdit.pdf 10 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedrenalcell carcinoma stainedwithCD10antibody(RMAB037). Formalin fixed paraffin embeddedhumanrenalcell carcinoma (PDM107). stainedwithCD10/CALLA cells within adult bone marrow, and germinal center B cellshas been identified within on the surfacelymphoid of early lymphoid tissue.progenitor cells, immature B antigen(CALLA). antigenleukemia lymphocyticCD10 acute common as known Specificity: Cellular Localization: Positive Control: Isotype: domain of the CD10 glycoprotein. leiomyoma (UCL) and uterine leiomyosarcoma (ULS). D0 CD10 Anti-Human Monoclonal Rabbit D0CLA CD10/CALLA Monoclonal MouseAnti-Human Immunogen: PDM107-10MMPrediluted 10ml PDM107Prediluted 6ml Mob240-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob240Concentrated 1ml Clone: cellular uterine from (ESS) sarcoma stromal endometrial differentiating in helpful is cells.stromalIt endometrial of marker a be to known also is It crisis. blast lymphoid in leukemias myelogenous chronic and some tumors, hematopoietic lymphoma, Burkitt lymphoma, follicular leukemia, of lymphoblastic cases of acute percentage high a in expressed is CD10 leukemia. and lymphoma malignant of types certain of classification and identification the for used been tubular. In liver, the bile canaliculi shows a moderate to a strong staining. CD10 with has reacts also variety It of non-hematopoietic granulocytes.cells, including and epithelial the cells folliclesin of GI tract lymphoid cells and kidney B of cells, centers B germinal and T immature as such cells hematopoietic of number a by expressed is P.CD10 substance and bombesin enkephalins, the including avarietyinactivates ofpeptidegrowth for factorsimportant signaltransductionand cleaves that metallo-endopeptidase transmembrane II type single-pass a Specificity: Cellular Localization: Positive Control: Isotype: CD10 protein. Immunogen: RMPD037Prediluted 6ml Status:Regulatory IVD Catalog No.: RMAB037 Concentrated 0.5ml Clone: ------56C6 EP195 IgG1 Rabbit Rabbit IgG The common acute lymphoblastic leukemia antigen (CALLA/CD10) is This antibody is specific to human CD10 antigen of 100 kDa, also kDa, 100 of antigen CD10 human to specific is antibody This Prokaryotic recombinant protein corresponding to the external external the to corresponding protein recombinant Prokaryotic rcmiat rget orsodn t rsde i human in residues to corresponding fragment recombinant A Tonsil, renal cell carcinoma Tonsil, renal cell carcinoma, follicular lymphoma Cell membrane Cytoplasmic Cell Membrane 3 60 F F ,/ ,/ P P H H
26
Formalin fixed paraffin embeddedhumantonsilstainedwithCD11c(Mob485). Formalin fixed paraffin embeddedhumanHodgkin’s lymphomastainedwithCD15(RMAB101). with histiocytic origin. It may also be used as a marker for hairy cell expressionleukemia. on most DCs. An antibody to CD11c may aid in identification of of level high lesions its of result a as neutrophils on observed also is expression of level monocytes, tissue macrophages, NK cells, and most dendritic cells (Dcs). A lower Specificity: Cellular Localization: Positive Control: Isotype: 850) of human ITGAX protein. Immunogen: PDM198-10MMPrediluted 10ml PDM198Prediluted 6ml Status:Regulatory IVD Catalog No.: Mob485Concentrated 1ml Clone: CD11c Monoclonal MouseAnti-Human expressed in large cell occasionally lymphomas is of CD15 both Hodgkin’sdisease. B of identification and in T useful phenotypes. very is CD15 Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: RMPD101-10RMPrediluted 10ml RMPD101Prediluted 6ml RMAB101-1 Concentrated 1ml Status:Regulatory IVD Catalog No.: RMAB101 Concentrated 0.5ml Clone: CD15 Anti-Human Monoclonal Rabbit ------DBM15.16 DBR16.16
Rabbit IgG IgG, kappa CD15 isexpressed inReed-Sternberg cellsandsomeepithelialcells. D1 i epesd rmnnl o te lsa ebae of membranes plasma the on prominently expressed is CD11c Purified human neutrophils. Recombinant fragment (191 Amino acid residues between aa 600- Lung carcinoma, tonsil Hodgkin’s lymphoma
Cell surface Cell surface and granular paranuclear
3 60 3 60 F F ,/ ,/ P P H H
NEW NEW 2/17/17 5:00PM Primary Antibodies 2/17/17 5:00 PM NEW www.dbiosys.com H P ,/ H F P ,/ F 3 6 0 3 6 0 Cell membrane and cytoplasm and membrane Cell Tonsil Tonsil Recombinant human MS4A1 protein. MS4A1 human Recombinant BALB/C mice were injected with U937 histiocytic cell line. cell histiocytic U937 with injected were mice BALB/C This antibody reacts with a 220 kDa protein. CD15 plays a role in CD20 is a non-Ig differentiation antigen of B-cells and its expression is expression its and B-cells of antigen differentiation non-Ig a is CD20 IgG IgM, kappa IgM, MMA; same as LeuM1 MMA; CD20/MS4A1 ------Clone: 1ml Mob365 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob365-05 Concentrated 6ml PDM127 Prediluted 10ml PDM127-10MM Prediluted Monoclonal Mouse Anti-Human Monoclonal AntigenCD15/Granulocyte Associated Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: Immunogen: Isotype: Control: Positive membrane Cell Localization: Cellular Specificity: Monoclonal Rabbit Anti-Human CD20/MS4A1 Clone: 0.5ml Concentrated RMAB095 No.: Catalog IVD Regulatory Status: 1ml Concentrated RMAB095-1 6ml RMPD095 Prediluted 10ml RMPD095-10RM Prediluted restricted to normal and neoplastic B-cells, being absent from all other leukocytes other all from absent being B-cells, neoplastic and normal to restricted mediating phagocytosis, bactericidal activity and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils cells and some in Reed-Sternberg CD15 is also expressed on monocytes. degree and disease. Hodgkin to of identification a the in lesser useful very is CD15 cells. epithelial and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell of stages all during persists and B-cells pre by expressed is CD20 tissues. and maturation but is lost B cells, malignant and leukemia of immnophenotyping upon for used be can antibody terminal differentiation into plasma lymphocyte cells. detection This in peripheral blood and B cell localization reacts in with tissues. It the majority B-cell a ascribing of for antibody reliable B-cells a is It present lymphomas. derived in their and tissues peripheral blood and lymphoid tissues. lymphoid known in phenotype Formalin fixed paraffin embedded human tonsil stained with CD20/MS4A1 (RMAB095). paraffin fixed Formalin Formalin fixed paraffin embedded human Hodgkin’s lymphoma stained with CD15 (Mob365). embedded human Hodgkin’s paraffin fixed Formalin 27 H P P ,/ , F F 3 6 0 Cell membrane Cell Cell membrane Cell Tonsil Tonsil Purified neutrophils from normal human peripheral blood. peripheral human normal from neutrophils Purified Purified neutrophils from normal human peripheral blood. peripheral human normal from neutrophils Purified The specificity of this antibody is similar to antibodies Leu-M1, TU 9, Leu-M1, of this antibody is similar to antibodies The specificity The specificity of this antibody is similar to antibodies Leu-M1, TU 9, of this antibody is similar to antibodies Leu-M1, The specificity IgM, kappa IgM, IgM, kappa IgM, C3D-1 MY-1 ------Monoclonal Mouse Anti-Human AntigenCD15/Granulocyte Associated Monoclonal Mouse Anti-Human Monoclonal AntigenCD15/Granulocyte Associated and VIM-D5. It recognizes an epitope involving the carbohydrate sequence 3- fucosyl- N-acetyl-lactosamine. This antibody reacts with an antigen located cells. on Reed-Sternberg and Hodgkin on and granulocytes mature Positive Control: Control: Positive Localization: Cellular Specificity: Isotype: Immunogen: Clone: 1ml Mob147 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob147-05 Concentrated Clone: 1ml Mob024 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob024-05 Concentrated 6ml PDM098 Prediluted 10ml PDM098-10MM Prediluted Formalin fixed paraffin embedded human lymph node lymphoma stained with CD15 antibody paraffin fixed Formalin (Mob147). Formalin fixed paraffin embedded human lymph node lymphoma stained with CD15 antibody paraffin fixed Formalin (Mob024). and VIM-D5. It recognizes an epitope involving the carbohydrate sequence 3- fucosyl- N-acetyl-lactosamine. This antibody reacts with an antigen located cells. on Reed-Sternberg and Hodgkin on and granulocytes mature Immunogen: Localization: Cellular Specificity: Isotype: Control: Positive Page 27-36 Hard Edit.pdf 1 Page 27-36HardEdit.pdf 2 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithCD20,Bcell antibody(Mob004). Formalin fixed paraffin embeddedhumantonsilstainedwithCD20antibody(RMPD032). transcription factors. D0 CD20 Anti-Human Monoclonal Rabbit Immunogen: PDM004-10MMPrediluted 10ml PDM004Prediluted 6ml Mob004-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob004Concentrated 1ml Clone: CD20, BCell Monoclonal MouseAnti-Human other with hematopoietic reactivity cells No has tissue. been lymphoid observed. and blood peripheral in cells B of majority Specificity: Cellular Localization: Positive Control: Tonsil Isotype: ytei ad s huh t ivle ai hlxlo-ei luie zipper leucine helix-loop-helix basic involve to thought is and DNA increases synthesis significantly CD20 of Activation cells. T neoplastic and normal termini. CD20 is expressed primarily on C- B and cells N- but cytoplasmic has and also regions, been transmembrane detected four on of both consisting antigen Specificity: Cellular Localization: Cytoplasmic and membrane Positive Control: Isotype: Immunogen: RMPD032-10RMPrediluted 10ml RMPD032Prediluted 6ml RMAB032-1 Concentrated 1ml Status:Regulatory IVD Catalog No.: RMAB032 Concentrated 0.5ml Clone: ------L26 BV11 IgG2a, kappa IgG This antibody reacts with CD20, which is a 33kDa leukocyte surface surface leukocyte 33kDa a is which CD20, with reacts antibody This hs nioy s pcfc o 3 ka oyetd peet n the on present polypeptide kDa 33 a to specific is antibody This BALB/C mice were injected with human tonsil B cells. A synthetic peptide from the C-terminus of human CD 20 protein. Tonsil Cell membrane and cytoplasm 3 60 3 60 F F , , P P 28 Formalin fixed paraffin embeddedtonsilstainedwithCD21antibody(RMAB073). Formalin fixed paraffin embeddedhumantonsilstainedwithCD21antibody(Mob028). ate oe f ypod ise. t s ueu mre t ietf neoplasms identify to marker useful derived a from follicular is dendritic cells. It tissues. lymphoid of and zone marginal mantle in particularly cells B mature and cells antibody dendritic CD21 follicular virus. labels Epstein-Barr the and C3d for receptor complement the Specificity: Cellular Localization: Positive Control: Isotype: of human CD21 protein was used as an immunogen. Immunogen: RMPD073Prediluted 6ml RMAB073-1 Concentrated 1ml Status:Regulatory IVD Catalog No.: RMAB073 Concentrated 0.5ml Clone: CD21 Anti-Human Monoclonal Rabbit interior of the B cell. dendritic cells. CD21 is involved in transmitting growth-promoting signals to the follicular on density high at presentcells. is B matureantigen The of surface the Specificity: Cellular Localization: Positive Control: Isotype: component CR2, from human tonsil. Immunogen: PDM122Prediluted 6ml Mob028-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob028Concentrated 1ml Clone: CD21, BCell Monoclonal MouseAnti-Human ------EP64 1F8 Rabbit Rabbit IgG IgG1, kappa This antibody reacts with CD21 antigen of MW 145 kDa, present on present kDa, 145 MW of antigen CD21 with reacts antibody This CD21 is a single-pass type 2 transmembrane protein that serves as serves that protein transmembrane 2 type single-pass a is CD21 A synthetic peptide corresponding to residues on the C-terminus the on residuesto corresponding peptide synthetic A Purified receptor for the C3d fragment of the third complement third the of fragment C3d the for receptor Purified Tonsil, lymphoma Tonsil Cell Membrane Cell membrane F F ,/ , P P H 2/17/17 5:00PM Primary Antibodies 2/17/17 5:00 PM www.dbiosys.com H H P P ,/ ,/ F F Cell membrane Cell Cell Membrane Cell Tonsil Tonsil A synthetic peptide corresponding to residues of human CD25 BALB/C mice were injected with recombinant human interleukin-2 human recombinant with injected were mice BALB/C CD25, or interleukin 2 (IL2) receptor alpha (IL2RA), and beta (IL2RB) This antibody is specific to a 55 kDa protein known as interleukin 2- IgG1, kappa IgG1, Rabbit IgG Rabbit IL2R.1 EP218 ------Monoclonal Mouse Anti-Human α CD25/IL-2R Monoclonal RabbitMonoclonal Anti-Human CD25 Immunogen: receptor. Isotype: Control: Positive Localization: Cellular Specificity: receptor α α). (IL-2R α IL-2R is over expressed on the surface of T activated cells, T positive or cell lines, HTLV-2 HTLV-1 and moderately expressed on activated B macrophages. and NK-cells, cells, Immunogen: protein. Isotype: Control: Positive Localization: Cellular Specificity: chains, together with the common gamma chain (IL2RG), constitute the high- affinity IL2 receptor. CD25 is the alpha chain of the IL-2 receptor. It transmembrane is a protein type I present on activated T cells and activated B cells. Clone: 1ml Mob254 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob254-05 Concentrated 6ml PDM144 Prediluted Clone: 0.5ml Concentrated RMAB074 No.: Catalog IVD Regulatory Status: 6 ml RMPD074 Prediluted Normally an integralmembrane protein, soluble CD25 has been determined to isolated result and from extracellular proteolysis. CD25 also appears to be a reliable immunohistochemical marker for the discrimination of neoplastic from normal/reactive mast cells, with potential as a diagnostic tool in systemic mastocytosis. CD25 is also expressed on hairy cell leukemia. cell hairy on expressed also is CD25 mastocytosis. Formalin fixed paraffin embedded human tonsil stained with CD25 antibody (Mob254). paraffin fixed Formalin Formalin fixed paraffin embedded tonsil stained with CD25 antibody (RMAB074). paraffin fixed Formalin 29 H H P P ,/ ,/ F F 3 6 0 3 6 0 Cell membrane Cell Cell membrane Cell Tonsil Tonsil Prokaryotic recombinant fusion protein corresponding to the Recombinant protein encoding human CD23 48-248 aa. 48-248 CD23 human encoding protein Recombinant This antibody is specific to a membrane glycoprotein of 45 kDa, This antibody recognizes CD23. CD23 is a 45kDa glycoprotein which glycoprotein 45kDa a is CD23 CD23. recognizes antibody This IgG IgG1, kappa IgG1, SP23 1B12 ------Positive Control: Control: Positive Localization: Cellular Specificity: Isotype: is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells of Expression and cells. B strongly on found receptor expressed IgE affinity on low the to EBV-transformed identical is B molecule lymphoblasts. The CD23 CD23 has been detected in neoplastic cells from cases of B cell chronic Immunogen: Monoclonal Rabbit Anti-Human Monoclonal Mouse Anti-Human Monoclonal CD23 CD23 Positive Control: Control: Positive Localization: Cellular Specificity: IVD Regulatory Status: external domain of the CD23 molecule. CD23 the of domain external Isotype: Clone: 0.5ml Concentrated RMAB013 No.: Catalog 6ml RMPD013 Prediluted 10ml RMPD013-10RM Prediluted Immunogen: Clone: 1ml Mob294 Concentrated No.: Catalog 0.5ml Mob294-05 Concentrated 6ml PDM143 Prediluted 10ml PDM143-10MM Prediluted lymphocyctic leukemia and some cases of centroblastic/centrocytic lymphoma. centroblastic/centrocytic of cases some and leukemia lymphocyctic designated as CD23. CD23 is found on a subpopulation of peripheral blood cells, B cells, blood peripheral of subpopulation a on found is CD23 CD23. as designated of Expression lines. cell lymphoblastoid B transformed EBV on and lymphocytes, CD23 has been detected in neoplastic cells from cases of B cell chronic Regulatory Status: IVD Regulatory Status: lymphocytic leukemias. lymphocytic Formalin fixed paraffin embedded human tonsil stained with CD23 antibody (RMAB013). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with CD23 antibody (Mob294). paraffin fixed Formalin Page 27-36 Hard Edit.pdf 3 Page 27-36HardEdit.pdf 4 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanHodgkin’s lymphomastainedwithCD30(RMAB038). Formalin fixed paraffin embeddedhumanHodgkin’s lymphomastainedwithCD30(Mob032). cells present around B cell follicles and sometimes at the rim of germinal lymphomas.centers. In normal lymphoid tissues, it reacts with a small population of large carcinomas (ECs), seminomas, embryonal and in hepatocellular reported carcinomas. been has reactivity CD30 malignancies, In non-lymphoid disorders. lymphoproliferative T-cell CD30+ cutaneous primary and (ALCL) been useful in identifying Hodgkin’s lymphoma, anaplastic large has cell lymphomas It cells. T and B activated labels antibody CD30 autoimmunity.The against body the protect and cells effector T CD8 autoreactive of proliferativepotential Hodgkin and Reed-Sternberg cells and by tumor cells of a majority of large cell large of majority a of cells tumor by and cells Reed-Sternberg and Hodgkin oiie euao o aotss ad t lo a be son o ii the limit to shown been has also it and apoptosis, of regulator positive a is receptor This NF-kappaB. of activation the to leads that transduction signal TNFSF8/CD30L. TRAF2 and TRAF5 can interact with this receptor and mediate the Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: PDM018-10MMPrediluted 10ml PDM018Prediluted 6ml Mob032-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob032Concentrated 1ml Clone: CD30/Ki-1 Antigen Monoclonal MouseAnti-Human Anti-Human Monoclonal Rabbit Specificity: Specificity: Cellular Localization: Positive Control: Isotype: human CD30 protein. Immunogen: RMPD038Prediluted 6ml RMAB038-1 Concentrated 1ml Status:Regulatory IVD Catalog No.: RMAB038 Concentrated 0.5ml Clone: CD30 ------Ber-H2 EP154 IgG1, kappa Rabbit Rabbit IgG hs nioy ecs ih 15 D gyorti epesd by expressed glycoprotein kDa 105 a with reacts antibody This D0 TFrcpo spraiy ebr i a eetr for receptor a is member, superfamily TNF-receptor CD30, BALB/C mice were immunized with L428 cell line. A synthetic peptide corresponding to residues at the C-terminus of Tonsil Tonsil, Hodgkin’s lymphoma Cell membrane Cytoplasmic cell membrane 3 60 F F ,/ ,/ P P H H 30 (RMAB097). Formalin fixed paraffin embeddedhumanHodgkin’s lymphomastainedwithCD30/TNFRSF8 Formalin fixed paraffin embeddedhumanHodgkin’s lymphomastainedwithCD30(Mob500). itoyi mlgace ad ypoa drvd rm etn ad precursor and lymphoid cells resting or from from anaplastic derivedcarcinomas. lymphomas and malignancies histiocytic from cells lymphoid activated from derived lymphomas cell large distinguishes el s y vrig rprin f ciae T n B el. hs antibody This cells. B and T activated of proportion varying a by as well celllymphomasas ofanaplasticlarge expressed bythetumorcellsofamajority ooula-ogi ad utncetd edSeneg el. t s also is It cells. Reed-Sternberg multinucleated and mononuclear-Hodgkin seminomas, and hepatocellular carcinomas. malignancies, CD30 reactivity has been reported in embryonal carcinomas (Ecs), cutaneous primary CD30+ T-cell lymphoproliferative disorders. and In non-lymphoid (ALCL) lymphomas cell large anaplastic lymphoma, Hodgkin’s identifying Specificity: Cellular Localization: Positive Control: Hodgkin’s lymphoma Isotype: Immunogen: Status:Regulatory IVD lcpoen f 0/2ka ietfe a C3/i1 I hs en sfl in useful by been expressed has is antigen It CD30/Ki-1 lymphoma, CD30/Ki-1. Hodgkin’s identifying as identified 105/120kDa, chain of single a glycoprotein recognizes superfamily, receptor (TNF) factor necrosis tumour Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: RMPD097-10RMPrediluted 10ml RMPD097Prediluted 6ml RMAB097-1 Concentrated 1ml Status:Regulatory IVD Catalog No.: RMAB097 Concentrated 0.5ml Clone: CD30/TNFRSF8 Anti-Human Monoclonal Rabbit D0 PDM228-10MMPrediluted 10ml PDM228Prediluted 6ml Catalog No.: Mob500Concentrated 1ml Clone: CD30 Monoclonal MouseAnti-Human ------DBR16.12 DBM15.26 Rabbit IgG IgG1, kappa The CD30 antibody labels activated B and T cells. It has been useful in D0 s tasebae yoie eetr eogn t the to belonging receptor cytokine transmembrane a is CD30 Recombinant human TNFRSF8 protein. Recombinant human TNFRSF8 protein. Hodgkin’s Lymphoma Cell surface Cell membrane 3 60 3 60 F F ,/ ,/ P P H H NEW NEW 2/17/17 5:00PM Primary Antibodies 2/17/17 5:00 PM www.dbiosys.com H H P P ,/ ,/ F F Cell Membrane Cell Cell Membrane Cell Placenta, angiosarcoma Placenta, Tonsil A synthetic peptide corresponding to residues on human CD31 Purified Purified recombinant fragment of CD31 fusion protein expressed CD31, also known as PECAM-1, is a 130 kDa integral membrane CD31 (also named platelet/endothelial cell adhesion molecule 1 – Rabbit IgG Rabbit IgG1 EP78 DB10.1 ------Immunogen: protein. Isotype: Control: Positive Localization: Cellular Specificity: glycoprotein found on the surface hematopoietic The cells. antibody of labels endothelial cells of endothelial arteries, arterioles, cells, platelets most the is CD31 tissues. various in capillaries non-sinusoidal and and veins, venules, some Itand sensitive specific is endothelial useful cell marker. detectionfor of tumors with endothelial origin. Inmarker prognostic a addition, is which CD31 angiogenesis of has assessment and tumors, been of invasion used to identify vascular cancer. of types many for Monoclonal Rabbit Anti-Human CD31 Monoclonal Mouse Anti-Human Monoclonal CD31(PECAM-1) Immunogen: E.Coli. in Isotype: Control: Positive Localization: Cellular Specificity: Clone: 0.5ml Concentrated RMAB057 No.: Catalog IVD Regulatory Status: 1ml Concentrated RMAB057-1 0.5ml RMPD057 Prediluted Clone: 1ml Mob470 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob470-05 Concentrated 6ml PDM183 Prediluted PECAM-1) is expressed vascular of identification on the for tool endothelial useful a is cells antibody This and cells. hematopoietic circulating and tissue-phase disorders (e.g. angiosarcoma) and determination of angiogenesis in some tumors. Positive results aid in tumors. Positive the classification of benign and malignant human vascular disorders. CD31 is useful to aid in the identification tissue. of soft epithelioid and and skin the in tumors spindled Formalin fixed paraffin embedded human colon carcinoma stained with CD31 (RMAB057). carcinoma embedded human colon paraffin fixed Formalin Formalin fixed paraffin embedded human colon carcinoma stained with CD31 (Mob470). stained carcinoma embedded human colon paraffin fixed Formalin 31 NEW H H P P ,/ ,/ 3 6 0 F F 3 6 0 Nuclear Prostate Prostate carcinoma, tonsil, squamous lung carcinoma, breast Tonsil BALB/C mice were immunized with membrane preparation of a Recombinant human CD31p63 protein fragment. protein CD31p63 human Recombinant This antibody reacts with a 100 kDa glycoprotein expressed by CD31 is expressed by stem cells of the hematopoietic system and is IgG IgG1, kappa IgG1, JC/70A DBR16.4 ------carcinoma Localization: Cellular Immunogen: Positive Control: Specificity: as studies experimental for cells these concentrate and identify to used primarily well as for bone marrow transplantation. Anti-CD31 has specific shown and to be sensitive highly for vascular tumors endothelial (excluding cells. hematopoietic Staining neoplasms) of is nonvascular rare. CD31 normal, benign, MAb and malignant reacts endothelial with cells which make up blood The level lining. of CD31 vessel expression can help to determine the degree of tumor Isotype: Monoclonal Mouse Anti-Human CD31, Endothelial Cell Monoclonal RabbitMonoclonal Anti-Human CD31/PECAM-1 spleen from a patient with hairy cell leukemia. cell hairy with patient a from spleen Isotype: Control: Positive Immunogen: membrane Cell Localization: Cellular Specificity: Clone: 1ml Mob034 Concentrated No.: Catalog 0.5ml Mob034-05 Concentrated 6ml Prediluted PDM020 10ml Prediluted PDM020-10MM angiogenesis, angiogenesis, and a high level of CD31 expression may imply a rapidly growing recurrence. tumor of predictor a potentially and tumor Clone: 0.5ml Concentrated RMAB088 No.: Catalog 6ml Prediluted RMPD088 IVD Regulatory Status: 1ml Concentrated RMAB088-1 10ml RMPD088-10RM Prediluted endothelial cells tissues. malignant and as well a as normal in 130 cells endothelial kDa glycoprotein present in platelets. It stains Regulatory Status: IVD Regulatory Status: Formalin fixed paraffin embedded human colon carcinoma stained with CD31 (Mob034). carcinoma embedded human colon paraffin fixed Formalin Formalin fixed paraffin embedded human colon carcinoma stained with CD31 (RMAB088). carcinoma embedded human colon paraffin fixed Formalin Page 27-36 Hard Edit.pdf 5 Page 27-36HardEdit.pdf 6 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanrenalcell carcinoma stainedwithCD34(Mob098). Formalin fixed paraffin embeddedhumantonsilstainedwithCD34antibody(RMAB058). gastrointestinal stromal of tumors. detection in aids CD34 addition, In differentiation. lymphoid or endothelial with tumors of identification in useful is progenitor/stemhematopoietic cells. It other and stromal components. CD34 is fibroblasts an important marker for quantifying and purifying cells, endothelial on cells, expressed stem/progenitor is CD34 hematopoietic cells. stromal or ECM marrow, bone the to attachment ypoeaooei dvlpet n psil mdae te tm cell stem the mediates possibly and development lymphohematopoietic factor. As an adhesion factor, CD34 is expressed during stem/progenitor stage of adhesion cell to cell a as functions primary glycoproteinwhich transmembrane Regulatory Status:Regulatory IVD D001M rdltd1m PDM050-10MMPrediluted 10ml PDM050Prediluted 6ml Mob098-05Concentrated 0.5ml Catalog No.: Mob098Concentrated 1ml Clone: the vascular endothelial cells. the surface of hematopoietic cells i.e. myeloid and lymphoid progenitors. It stains Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: D4 nohla el CD34, EndothelialCell Monoclonal MouseAnti-Human Specificity: Cellular Localization: Positive Control: Isotype: protein. Immunogen: RMPD058Prediluted 6ml Status:Regulatory IVD Catalog No.: RMAB058 Concentrated 0.5ml Clone: CD34 Anti-Human Monoclonal Rabbit ------QBEND/10 EP88 IgG1, kappa Rabbit Rabbit IgG This antibody reacts with a glycoprotein of MW 110 kDa, present on D4 Cutr f ifrnito 3) s snl-as ye I type single-pass a is 34) differentiation of (Cluster CD34 Endothelial cells (HUVE). A synthetic peptide corresponding to C-terminal of human CD34 human of C-terminal to corresponding peptide synthetic A Tonsil, kidney Placenta, angiosarcoma Cell membrane Cell Membrane 3 60 F , P 32 Formalin fixed paraffin embeddedhumantonsilstainedwithCD35(Mob255). Formalin fixed paraffin embeddedhumantonsilstainedwithCD43T-cell antibody(Mob039). Monoclonal MouseAnti-Human This antibody does not cross-react with CR2. activity. CR1 block to unable is it that site,so C3b-binding the from distal is that as the complement receptor 1 (CR1/CD35). This antibody recognizes a site in CR1 Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: Mob255-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob255Concentrated 1ml Clone: CD35/CR1, Follicular DendriticCell Marker Monoclonal MouseAnti-Human epatc cls n meod ieg cls I srnl san T el i the in cells T stains strongly It cells. interfollicular areas lineage of normal myeloidlymphoid tissues. and cells T neoplastic Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: PDM060-10MMPrediluted 10ml PDM060Prediluted 6ml Mob039-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob039Concentrated 1ml Clone: CD43, T Cell ------E11 DF-T1 IgG1 IgG1, kappa This antibody is specific to a 210-220 kDa protein, which is identified hs nioy ecs ih n nie epesd y oml and normal by expressed antigen an with reacts antibody This BALB/C mice were injected with intact human monocytes. BALB/C mice were immunized with myeloblast cell line KG1. Tonsil Tonsil Cell membrane Cell Membrane 3 60 F , P F ,/ P H 2/17/17 5:00PM Primary Antibodies 2/17/17 5:00 PM www.dbiosys.com H P ,/ F H P ,/ F 3 6 0 Cytoplasmic, Cell Membrane Cell Cytoplasmic, Cell membrane Cell Tonsil, lymphoma Tonsil, Tonsil BALB/C mice were immunized with human peripheral blood A synthetic peptide corresponding to residues in the C-terminal CD45, also known as the leukocyte common antigen (LCA), is a The human leukocyte common antigen is a family of five or more Rabbit IgG Rabbit Both clones, IgG1, kappa IgG1, clones, Both PD7/26 + 2B11 EP68 ------Immunogen: protein. CD45 human of domain Isotype: Control: Positive Localization: Cellular Specificity: Monoclonal Mouse Anti-Human (LCA) Antigen Common CD45/Leukocyte Monoclonal RabbitMonoclonal Anti-Human CD45 Immunogen: lymphocytes to raise clone PD7/26 and with T isolated neoplastic cell cells from 2B11. clone raise to lymphoma Isotype: Control: Positive Localization: Cellular Specificity: transmembrane protein-tyrosine phosphatase (PTPase) that almost all is hematolymphoid expressed cells in including lymphocytes, granulocytes, Clone: 1ml Mob040 Concentrated No.: Catalog 0.5ml Mob040-05 Concentrated 6ml PDM009 Prediluted 10ml PDM009-10MM Prediluted Clone: 0.5ml Concentrated RMAB054 No.: Catalog IVD Regulatory Status: 6ml RMPD054 Prediluted Regulatory Status: IVD Regulatory Status: high of molecular MW glycoproteins weight 180, 190, 205 and 220 kDa, present on the surface of the majority of human leukocytes. This antibody labels monocytes and macrophages, but not in mature erythrocytes and lymphoid cells. It labels neoplastic B and T cells in non-Hodgkin lymphoma and in and lymphoma non-Hodgkin in cells T and B neoplastic labels It cells. lymphoid types. cell T and B of leukemias megakaryocytes. CD45 antibody labelling of the majority origin. hematopoietic of with tumors of hematolymphoid identification the for marker a is neoplasms Rare cases of undifferentiated and neuroendocrine carcinomas with CD45 positive staining have been reported. been have staining positive Formalin fixed paraffin embedded human tonsil stained with CD45/LCA antibody (PDM009). antibody embedded human tonsil stained with CD45/LCA paraffin fixed Formalin Formalin fixed embedded human tonsil stained with CD45 antibody (RMAB054). embedded fixed Formalin 33 NEW H H P P ,/ ,/ F F 3 6 0 Cell Surface Cell Cell membrane Cell Bladder tumor, tonsil tumor, Bladder Tonsil Recombinant fragment corresponding to the v4 domain of human of domain v4 the to corresponding fragment Recombinant BALB/C mice were injected with stimulated human leukocytes. human stimulated with injected were mice BALB/C The The CD44 molecule belongs to a family of cellular adhesion This antibody is specific to a cell surface of glycoprotein 80-95 kDa, IgG2a, kappa IgG2a, IgG2a DBM15.33 156-3C11 ------Monoclonal Mouse Anti-Human CD44v4 Monoclonal Mouse Anti-Human Monoclonal CD44/HCAM Immunogen: Cd44. Isotype: Control: Positive Localization: Cellular Specificity: Clone: 1ml Mob507 Concentrated No.: Catalog 6ml PDM235 Prediluted 10ml PDM235-10MM Prediluted Positive Control: Control: Positive Localization: Cellular Specificity: Immunogen: Isotype: Clone: 1ml Mob256 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob256-05 Concentrated 6ml PDM172 Prediluted molecules found on a wide range of normal and malignant cells mesothelial in and epithelial, hemopoiesis tissues. CD44 is a single gene with 20 which 10 exons, are normally of expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 (v1 exons to v10) are only expressed by splicing alternative of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies. Regulatory Status: IVD Regulatory Status: known as CD44. CD44 is expressed on the surface of lymphocytes, monocytes, and granulocytes. This antibody reacts with red cells pretreated with 2- aminoethlyl isothiouronium bromide (AET). bromide isothiouronium aminoethlyl Formalin fixed paraffin embedded human bladder tumor stained with CD44v4 (Mob507). paraffin fixed Formalin Formalin fixed paraffin embedded human bladder carcinoma stained with CD44 (PDM172). stained with CD44 embedded human bladder carcinoma paraffin fixed Formalin Page 27-36 Hard Edit.pdf 7 Page 27-36HardEdit.pdf 8 Primary Antibodies www.dbiosys.com Formalin fixed antibody(Mob041). paraffin embeddedhumantonsilstainedwithCD45RAB-Cell Formalin fixed paraffin embeddedhumantonsilstainedwithCD45RO, TCellantibody(PDM015). Regulatory Status:Regulatory IVD D051M rdltd1m PDM015-10MMPrediluted 10ml PDM015Prediluted 6ml Mob043-05Concentrated 0.5ml Catalog No.: Mob043Concentrated 1ml Clone: Immunogen: PDM061Prediluted 6ml Mob041-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob041Concentrated 1ml Clone: within both the CD4 and cells CD8 resting subsets of subpopulation and a mature thymocytes, activated most the with T reacts of cells. It cells.portion T resting a on only but cells T activated and thymocytes most on found Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: 4KB5 appears similar to two other anti-CD45RA antibodies. Clone monocytes. and cells of T population small a as well as blood, peripheral Specificity: Cellular Localization: Positive Control: Isotype: D5O el CD45RO, T Cell Monoclonal MouseAnti-Human BCellCD45RA, Monoclonal MouseAnti-Human ------UCHL1 4KB5 IgG2a, kappa IgG1, kappa This antibody reacts with most of the B cells in tissue sections, and in This antibody reacts with a 180 kDa glycoprotein of the CD45 family, BALB/C mice were immunized with hairy cell leukemia cells. BALB/C mice were immunized with IL-2 dependent T cell line, CA1. Tonsil Tonsil Cell membrane Cell membrane 3 60 F F , , P P 34 Formalin fixed paraffin embeddedhumancolon carcinoma stainedwithCD56(Mob261). Formalin fixed paraffin embeddedhumantonsilstainedwithCD57antibody(Mob163). neuroblastoma. PDM110-10MMPrediluted 10ml PDM110Prediluted 6ml Mob261-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob261Concentrated 1ml Clone: neuroendocrine cells, and their tumors. PDM130-10MMPrediluted 10ml PDM130Prediluted 6ml Mob163-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob163Concentrated 1ml Clone: D6Nua elAhso oeue1(CM1 CD56/Neural (NCAM-1) Cell Adhesion Molecule-1 Monoclonal MouseAnti-Human D7 CD57 Monoclonal MouseAnti-Human epam sc a rtnbatm, eulbatm, srctm, and astrocytoma, medulloblastoma, retinoblastoma, and as tissues, such lines, neoplasms cell derived (NCAM/CD56). neuroectodermal most molecules on adhesion expressed cell is NCAM neural of isoforms two as identified Specificity: Cellular Localization: Positive Control: Isotype: cell lung carcinoma. Immunogen: lcpoen I san mnncer el wt ntrl ilr activity, killer natural with cells mononuclear stains It glycoprotein. Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: ------123C3.D5 NK-1 IgG1, kappa IgM This antibody is specific to a 110kDa human CD57 myeloid associated This antibody is specific to two proteins of 185 kDa and 145 kDa, 145 and kDa 185 of proteins two to specific is antibody This Human peripheral blood mononuclear cells. BALB/C mice were injected with membrane preparation of a small Neuroblastoma Tonsil Cell membrane Cell membrane 3 60 3 60 F , P F ,/ P H 2/17/17 5:00PM Primary Antibodies 2/17/17 5:00 PM NEW www.dbiosys.com H H P P ,/ ,/ F F 3 6 0 3 6 0 Cell membrane Cell Cytoplasmic Tonsil Liver, tonsil Liver, Subcellular fraction of human alveolar macrophages. alveolar human of fraction Subcellular Recombinant human CD68 protein. CD68 human Recombinant This This antibody recognizes a glycoprotein of 110kDa, which is This antibody is specific to macrophages in a wide variety of human of variety wide a in macrophages to specific is antibody This IgG1, kappa IgG1, IgG1, kappa IgG1, KP1 DBM15.9 ------Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: tissues. It reacts with myeloid precursors cells. and peripheral T blood plasmacytoidgranulocytes. It as known population cell a stains also Regulatory Status: IVD Regulatory Status: Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: Monoclonal Mouse Anti-Human CD68, Macrophage Clone: 1ml Mob167 Concentrated No.: Catalog 0.5ml Mob167-05 Concentrated 6ml PDM066 Prediluted 10ml PDM066-10MM Prediluted Clone: 1ml Mob492 Concentrated No.: Catalog IVD Regulatory Status: 6ml PDM208 Prediluted 10ml PDM208-10MM Prediluted Monoclonal Mouse Anti-Human Monoclonal CD68 identified as CD68. It is important for identifying macrophages in tissue sections. tissue in macrophages identifying for important is It CD68. as identified It cells in a wide variety stains macrophages including Kupffer of human tissues, and macrophages in the red pulp peripheral of the and spleen, in precursors lamina propria of myeloid the gut, with in reacts It marrow. bone in and alveoli, lung supposed which are T cells, Itblood granulocytes. also reacts with plasmacytoid to be of monocyte/macrophage origin. of cases It rare with reacts also and shows leukemia myeloid acute strong and chronic of staining granular cytoplasmic granules. few show or negative are Lymphomas neoplasia. histiocytic true Formalin fixed paraffin embedded human tonsil stained with CD68 Macrophage (PDM066). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with CD68 (Mob492). paraffin fixed Formalin 35 H E P P ,/ ,/ F F 3 6 0 Cytoplasmic Cell membrane Cell Melanoma Tonsil Smooth plasma membrane fraction of MeWo cells. MeWo of fraction membrane plasma Smooth BALB/C mice were immunized with PHA-stimulated human PHA-stimulated with immunized were mice BALB/C This antibody is specific to 53 kDa protein, expressed on activated This antibody recognizes a glycoprotein of 110 kDa molecular weight weight molecular kDa 110 of glycoprotein a recognizes antibody This IgG1, kappa IgG1, IgG1, kappa IgG1, NKI/C3 (same as MX-49.129.5) Y2/51 ------platelets. platelets. CD63 is a B granulocytes, lysosomal on membrane expressed also glycoprotein is It that activation. platelet is after membrane translocated plasma to cells. T and cells, Immunogen: Control: Positive Localization: Cellular Specificity: Isotype: Clone: 1ml Mob301 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob301-05 Concentrated present present on human platelets and also reacts with megakaryocytes and Monoclonal Mouse Anti-Human CD63 Positive Control: Control: Positive Localization: Cellular Specificity: mononuclear cells. mononuclear Isotype: Immunogen: Monoclonal Mouse Anti-Human Monoclonal IIIa Glycoprotein CD61/Platelet Clone: 1ml Mob164 Concentrated No.: Catalog 0.5ml Mob164-05 Concentrated 6ml PDM064 Prediluted 10ml PDM064-10MM Prediluted Regulatory Status: IVD Regulatory Status: megakaryoblasts. The antigen is also present on endothelium and osteoclasts. The glycoprotein IIIa molecule produced IIIa. by glycoprotein endothelium platelet to cells sequence is identical in Formalin fixed paraffin embedded human melanoma stained with CD63 antibody (Mob301). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with CD61 antibody (Mob164). paraffin fixed Formalin Page 27-36 Hard Edit.pdf 9 Page 27-36HardEdit.pdf 10 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithCD74antibody(Mob168). Formalin fixed paraffin embeddedhumantonsilstainedwithCD68antibody(Mob094). neoplastic cells in T cell lymphomas and Reed-Sternberg cells. their precursor cells. and granulocytes with non-reactivity its of because (CD68) EMB11 from differs PG-M1 The negative. are granulocytes peripheral and cells precursor tissues. Myeloid of variety wide a in macrophages stains It molecule. intracytoplasmic Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: PDM065-10MMPrediluted 10ml PDM065Prediluted 6ml Mob094-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob094Concentrated 1ml Clone: CD68, Macrophage Monoclonal MouseAnti-Human dniiain f cl lmhms n lueis I as san activated stains also It leukemias. and lymphomas cell B of identification Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: PDM033Prediluted 6ml Mob168-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob168Concentrated 1ml Clone: CD74, Lymphoid Marker Monoclonal MouseAnti-Human ------PG-M1 LN2 IgG1, kappa IgG3, kappa This antibody is specific to CD74. This antibody can be used for the for used be can antibody CD74. This to specific is antibody This This antibody reacts with a glycoprotein of 110 kDa, expressed as an BALB/C mice were immunized with Gaucher’s cells. SU-DHL-4 lymphoma cells. Tonsil Tonsil Cell membrane Cell membrane 3 60 F F ,// ,/ P P H H E 36 Formalin fixed paraffin embeddedhumantonsilstainedwithCD79aantibody(RMAB014). Formalin fixed paraffin embeddedhumantonsilstainedwithCD79aAntigen(PDM125). type, in B cell lines, B cell lymphomas, and in some myelomas. component. CD79a is found in the majority of acute leukemias of precursor B cell cell lines, and B cell lymphomas. CD79a antigen is found in majority of acute leukemias of precursor B cell type,stage. cell plasma The the until persists in and maturation in early stage,cell B pre-B this complex are designated CD79a and CD79b. The CD79a antigen appears at the immunoglobulins constitute the B cell antigen receptor. The two components of on imngouis n cls Ti cmlx f oyetd and polypeptide of complex This cells. membrane- B with on associated immunoglobulins bound non-covalently polypeptides two of consisting esss ni te lsa el tg wee t s on a a intracellular an as found is it where stage cell and plasma stage the cell B until pre at persists appears first CD79a receptor. Ag cell B the constitute is It polypeptides. B29 noncovalently associated / with membrane-bound immunoglobulins on CD79b B cells to and mb-1 / CD79a of consisting heterodimer Specificity: Specificity: Cellular Localization: Positive Control: Isotype: protein. Immunogen: RMPD014-10RMPrediluted 10ml RMPD014Prediluted 6ml Status:Regulatory IVD Catalog No.: RMAB014 Concentrated 0.5ml Clone: CD79a Anti-Human Monoclonal Rabbit Specificity: Specificity: Cellular Localization: Positive Control: Isotype: GTYQDVGSLNIADVQ. Immunogen: PDM125-10MMPrediluted 10ml PDM125Prediluted 6ml Mob242-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob242Concentrated 1ml Clone: CD79a Antigen Monoclonal MouseAnti-Human ------SP18 HM47/A9 IgG IgG1, kappa This antibody recognizes CD79a. CD79a is a disulphide-linked disulphide-linked a is CD79a CD79a. recognizes antibody This hs nioy s pcfc o ua C7a nie complex, antigen CD79a human to specific is antibody This Synthetic peptide derived from N-terminal region of human CD79a ytei plppie ossig f h aio cd sequence acid amino the of consisting polypeptide Synthetic Tonsil Tonsil Cell membrane Cell membrane 3 60 3 60 F F ,/ ,/ P P H H 2/17/17 5:00PM Primary Antibodies www.dbiosys.com H P ,/ H P ,/ F F 3 6 0 Cell membrane Cell Cell membrane Cell Tonsil, thymoma Tonsil, Small intestine Small BALB/C mice were injected with purified E-rosette forming cells A synthetic peptide from the C-terminus of human Fas protein. Fas human of C-terminus the from peptide synthetic A This antibody reacts with a 48 kDa transmembrane glycoprotein, This antibody is specific to a sialoglycoprotein of 27-32 kDa known as known kDa 27-32 of sialoglycoprotein a to specific is antibody This IgM HO36-1.1 ------lymphocytes, cortical thymocytes and granulosa cells of the ovary, Sertoli cells of cells Sertoli ovary, the of cells granulosa and thymocytes cortical lymphocytes, CD99 or MIC2 gene product. CD99 is expressed on the cell membrane of some the testis, pancreatic islet cells and some endothelial cells. Mature granulocytes CD99. no or little very express from human peripheral blood lymphocytes. blood peripheral human from Monoclonal Mouse Anti-Human Marker Sarcoma CD99/MIC2, Ewing’s Polyclonal Rabbit Anti-Human Polyclonal Immunogen: CD95/Fas CD95/Fas 1ml RP065 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml RP065-05 Concentrated Immunogen: Clone: 1ml Mob262 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob262-05 Concentrated 6ml PDM106 Prediluted 10ml PDM106-10MM Prediluted Isotype: Control: Positive Localization: Cellular Specificity: Positive Control: Control: Positive Localization: Cellular Specificity: known as CD95 (Fas). The Fas antigen is The knownFas expressed on as the CD95 surface(Fas). of various cell types, types, including T activatedand B lymphocytes T and lymphoblastoid cell lines. CD95 mediates receptor-triggered apoptosis. receptor-triggered mediates CD95 Formalin fixed paraffin embedded human small intestine stained with CD95/Fas antibody (RP065). embedded human small intestine stained with CD95/Fas paraffin fixed Formalin Formalin fixed paraffin embedded human Ewing’s sarcoma stained with CD99/MIC2 (PDM106). sarcoma embedded human Ewing’s paraffin fixed Formalin 37 H H P P ,/ ,/ F F Cell membrane Cell Cell membrane Cell Tonsil Tonsil Synthetic Synthetic peptide comprising of 202-216 C terminal amino acids A synthetic peptide derived from the N-terminal region of human the N-terminal region from A synthetic peptide derived CD79a is a disulfide-linked heterodimer, CD79a consisting is of a CD79a/ disulfide-linkedmb-1 heterodimer, This antibody reacts specifically with B cells at the pre B cell stage. It stage. cell B pre the at cells B with specifically reacts antibody This IgG1, kappa IgG1, HM57 ------and CD79b/B29 and first CD79a isreceptor. antigen cell B the constitute to cells B on immunoglobulins non-covalently associated with membrane-bound CD79a/mb-1, B Cell Marker Marker CD79a/mb-1, B Cell Immunogen: Clone: 1ml Mob118 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob118-05 Concentrated Polyclonal Rabbit Anti-Human Polyclonal Monoclonal Mouse Anti-Human Monoclonal CD79a, B Cell found in the majorityfound B in B cell lines, of acute leukemias of precursor B celltype, myelomas. some in and lymphomas cell Immunogen: RP101 Concentrated 1ml RP101 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml RP101-05 Concentrated CD79a protein. CD79a Control: Positive Localization: Cellular Specificity: appears at pre B cell stage where it is found as an intracellular coponent. CD79a is CD79a coponent. intracellular an as found is it where stage cell B pre at appears part of mb-1 protein. mb-1 of part Cellular Localization: Localization: Cellular Specificity: Isotype: Control: Positive stains a majority of acute leukemias of precursor B cell type, B cell lymphomas, and some myelomas. The mb-1 polypeptide along with B29 polypeptide forms an forms polypeptide B29 with along polypeptide mb-1 The myelomas. some and phosphorylation functions. phosphorylation antigen receptor complex on the B cell, performing signal transduction and Formalin fixed paraffin embedded human tonsil stained with CD79a antibody (RP101). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with CD79a antibody (Mob118). paraffin fixed Formalin Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanEwing’s sarcoma stainedwithCD99(RMAB104). Formalin fixed paraffin embeddedEwing’s sarcoma stainedwithCD99antibody(RMAB050). and other malignancies. and other malignancies. subset of other tumors including lymphoblastic lymphoma, breast carcinoma breast lymphoma, lymphoblastic including tumors other of subset subset of other tumors including lymphoblastic lymphoma, breast carcinoma breast lymphoma, lymphoblastic including tumors other of subset Specificity: Cellular Localization: stromal tumor, endocrine tumor of pancreas. Additionally, CD99 is found in a in found is CD99 Additionally, pancreas. of tumor endocrine tumor, stromal cells, granulosa ovarian lymphocyte, labels CD99 cell. neuroectodermal Positive Control: Isotype: of human CD99 protein. Specificity: Cellular Localization: a in found is CD99 Additionally, pancreas. of tumor endocrine tumor, stromal Positive Control: Isotype: of human CD99 protein. neuroectodermal cell. CD99 labels lymphocyte, ovarian granulosa cells, cells, granulosa ovarian lymphocyte, labels CD99 cell. neuroectodermal RMPD104-10RMPrediluted 10ml RMPD104Prediluted 6ml RMAB104-1 Concentrated 1ml Catalog No.: RMAB104 Concentrated 0.5ml Clone: RMPD050Prediluted 6ml RMAB050-1 Concentrated 1ml Status:Regulatory IVD Catalog No.: RMAB050 Concentrated 0.5ml Clone: acetc se cls Sroi el, N eedml el ad nohla cells. endothelial and cells ependymal CNS cells, Sertoli cells, islet pancreatic primitive of differentiation and migration leukocyte adhesion, cell involvedin T D9 CD99 CD99 Monoclonal Rabbit Anti-Human Monoclonal Rabbit Anti-Human Monoclonal Rabbit Regulatory Status:Regulatory IVD Immunogen: Antibody to CD99 has been useful in diagnosis of Ewing's sarcoma, sex cord- sex sarcoma, Ewing's of diagnosis in useful been has CD99 to Antibody Immunogen: acetc se cls sroi el, N eedml el ad nohla cells. endothelial and cells ependymal CNS cells, sertoli cells, islet pancreatic primitive of differentiation and migration leukocyte adhesion, cell involvedin T cord- sex sarcoma, Ewing's of diagnosis in useful been has CD99 to Antibody ------DBR16.19 EP8 Rabbit Rabbit IgG Rabbit Rabbit IgG CD99 is a transmembrane glycoprotein, also known as MIC2. It is It MIC2. as known also glycoprotein, transmembrane a is CD99 CD99 is a transmembrane glycoprotein, also known as MIC2. It is It MIC2. as known also glycoprotein, transmembrane a is CD99 A synthetic peptide corresponding to residues on the C-terminus the on residuesto corresponding peptide synthetic A A synthetic peptide corresponding to residues on the C-terminus the on residuesto corresponding peptide synthetic A Tonsil, Ewing’s sarcoma Tonsil, Ewing’s sarcoma Cell Membrane, Cytoplasm Membrane/Cytoplasm 3 60 F F / , / , P P H H NEW 38 Formalin fixed paraffin embeddedhumanEwing’s sarcoma stainedwithCD99(PDM200). Formalin fixed paraffin embeddedhumanskinangiosarcoma stainedwithCD105(RMAB090). leukocyte diapedesis. CD99 is expressed on the cell membrane of some some of membrane cell the on expressed is CD99 diapedesis. leukocyte thymo immature of apoptosis molecules, MHS and receptor cell T of various cellular processes including homotypic aggregation of T cells, upregulation 32kDa (p30/32). Although its function is not fully understood, CD99 is implicated in tissue sections correlatestissue sections significantlywithtumoraggressiveness andprognosis hypoxia-inducible and proliferation-associated a is CD105 II. and/or I receptors alternative splicing of the CD99 gene transcript and are identified as bands of 30 and in many types solid tumors. β1 and -β3, and modulates TGF- β signaling through interactions with TGF-β with interactions through signaling β TGF- modulates and -β3, and β1 density density assessed by CD105 immunohistochemical staining inparaffin-embedded protein abundantly expressed in angiogenic endothelial cells. Tumor microvessel Specificity: Cellular Localization: Positive Control: Isotype: RMPD090-10RMPrediluted 10ml RMPD090Prediluted 6ml RMAB090-1 Concentrated 1ml Catalog No.: RMAB090 Concentrated 0.5ml Clone: Immunogen: CD105 Anti-Human Monoclonal Rabbit Immunogen: Regulatory Status:Regulatory IVD Specificity: Cellular Localization: Positive Control: Isotype: protein. Ewing’s sarcoma cells and primitive peripheral neuroectodermal tumors. Maturegranulocytes express verylittle CD99.noor MIC2 stronglyis expressed on lymphocytes, cortical thymocytes, and granulosa cells of the ovary. Most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells express this antigen. D201M rdltd1m PDM200-10MMPrediluted 10ml PDM200Prediluted 6ml Status:Regulatory IVD Catalog No.: Mob487Concentrated 1ml Clone: D9MC CD99/MIC2 Monoclonal MouseAnti-Human ------EP274 DBM15.1 IgG1, kappa IgG CD105 functions as a receptor for transforming growth factor (TGF) - I2 ee noe to itnt rtis wih r poue by produced are which proteins, distinct two encodes gene MIC2 Recombinant full-length human MIC2 protein. A protein fragment corresponding to residues on human CD105 human on residues to corresponding fragment protein A Ewing's sarcoma, pancreas Skin Skin angiosarcoma Cell Surface Cytoplasmic 3 60 3 60 F F / , / , P P H H ye and cytes NEW Primary Antibodies www.dbiosys.com H H P P ,/ ,/ F F Cell Membrane Cell Membrane Tonsil, plasmacytoma Tonsil, Tonsil CD138, also known as Syndecan-1, is a member of the A synthetic peptide corresponding to residues in human CD138 Human CD163 antigen. CD163 Human The CD163 molecule is a type I membrane protein also known as Rabbit IgG Rabbit IgG1 10D6 EP201 ------matrix receptor and is involved in many cellular functions, including cell-cell transmembrane heparan sulfate proteoglycan family, acts as an extracellular adhesion and cell-matrix adhesion. CD138 expression is found in both protein. Isotype: Control: Positive Localization: Cellular Specificity: M130 antigen, Ber-Mac3, Ki-M8 or SM4. CD163 protein is restricted in its Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: Immunogen: Monoclonal Mouse Anti-Human CD163 Clone: 1ml Mob460 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob460-05 Concentrated Monoclonal RabbitMonoclonal Anti-Human CD138 Clone: 0.5ml Concentrated RMAB040 No.: Catalog IVD Regulatory Status: 6ml RMPD040 Prediluted and by phorbol esters. phorbol by and cells in both normal and tumor tissues. tumor and normal both in cells cells and Langerhans cells. In addition, multinucleated cells within inflammatory within cells multinucleated addition, In cells. Langerhans and cells glucocorticoids and downregulated by the immunosuppressant cyclosporin A expression to the monocytic/macrophage lineage. It is reported to be present on present be to reported is It lineage. monocytic/macrophage the to expression CD138 labels plasma cells. It is an excellent marker for plasmacytic differentiation differentiation plasmacytic for marker excellent an is It cells. plasma labels CD138 cells, cells, CD138 reactivity is observed in many types of epithelial cells and stroma mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum reticulum interdigitating follicles, lymphoid of centers germinal and zone mantle within the spectrumAmong non-hematolymphoid malignancy. of hematologic all circulating monocytes and most tissue macrophages except those found in the in found those except macrophages tissue most and monocytes circulating all by upregulated is protein The protein. CD163 express to not reported are lesions hematopoietic and non-hematopoietic cells. In the hematopoietic system, Formalin fixed paraffin embedded human tonsil stained with CD163 antibody (Mob460). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with CD138 (RMPD040). paraffin fixed Formalin 39 H H P P ,/ ,/ F F (Only for markets outside the U.S. For U.S. market, see index III.) see index market, U.S. For outside the U.S. markets for (Only (Only for markets outside the U.S. For U.S. market, see index III.) III.) see index market, U.S. For outside the U.S. markets for (Only Cell membrane, cytoplasm membrane, Cell Cell Membrane, Cytoplasm Membrane, Cell Tonsil Gastrointestinal stromal tumor tissue tumor stromal Gastrointestinal A synthetic peptide from C-terminus of human CD117/c-Kit A synthetic peptide corresponding to residues in the C-terminus of C-terminus the in residues to corresponding peptide synthetic A Member of the Tyrosine Kinase Receptor (TKRs) and highly This antibody reacts with a 145 kDa protein. CD117/c-Kit is a Rabbit IgG Rabbit EP10 ------protein. Control: Positive Localization: Cellular (Stem Cell factor) leads to autophosphorylation and association of c-Kit with Specificity: homologous to receptor PDF and CSF-1. Activation of c-Kit tyrosine kinase by SCF by kinase tyrosine c-Kit of Activation CSF-1. and PDF receptor to homologous This anti-CD117 has been validated with excellent staining result by NordiQC, an NordiQC, by result staining excellent with validated been has anti-CD117 This substrate PI3K. CD117 is a marker for Mast cell and gastrointerstinal stroma tumor. tumor. stroma gastrointerstinal and cell Mast for marker a is CD117 PI3K. substrate independent scientific organization, promoting the quality of immunohistochemistry for pathology laboratories. pathology for immunohistochemistry RP063 Concentrated 1ml RP063 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml RP063-05 Concentrated 6ml PDR045 Prediluted Clone: 0.5ml Concentrated RMAB039 No.: Catalog IVD Regulatory Status: 6ml RMPD039 Prediluted CD117/c-Kit CD117 Immunogen: Polyclonal Rabbit Anti-Human Polyclonal Immunogen: protein. CD117 human Isotype: Control: Positive Monoclonal RabbitMonoclonal Anti-Human transmembrane receptor tyrosine kinase and is expressed in many tissues and such as germ cells, neural crest derived melanocytes and hematopoietic Cellular Localization: Localization: Cellular Specificity: cells. CD117/c-Kit is involved in the development of several lineages of stem cells, cells, stem of lineages several of development the in involved is CD117/c-Kit cells. Formalin fixed paraffin embedded human gastrointestinal stromal tumor stained with CD117/c-Kit embedded human gastrointestinal stromal tumor stained with CD117/c-Kit paraffin fixed Formalin antibody (RP063). Formalin fixed paraffin embedded gastrointestinal stromal tumor stained with CD117 antibody paraffin fixed Formalin (RMAB039). precursor cells. This antibody can be used in the identification of gastrointestinal gastrointestinal of identification the in used be can antibody This cells. precursor stromal tumors. stromal Page 40-46 Hard Edit.pdf 1 Primary Antibodies www.dbiosys.com (Mob340). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithCdc47/MCM7antibody Formalin fixed paraffin embeddedhumantonsilstainedwithCdc25Aantibody(Mob337). G2 for Cdc25B. Cdc25C is mainly expressed in G2 phase. the cell cycle, with peak expression in G1 for Cdc25A and in both G1-S phase and throughout expressed are Cdc25B and Cdc25A andCDC25C. CDC25B CDC25A, and kinase Cdc25 phosphatases. Three CDC25 genes are present in human cells: 1 wee of action antagonistic the by controlled is which status, phosphorylation cells than hCdc47-positive their normal nuclear counterparts. more contain organs mucosa. several and from tumors epidermis Malignant marrow, bone nodes, lymph normal of components cell cycle. Expression of Cdc47 protein has been found in the nuclei of proliferative hCdc47 isamemberoftheMCMfamily, whichallowsDNAtoreplicate onceper Specificity: Cellular Localization: Positive Control: Breast carcinoma Isotype: cdc47 protein. Immunogen: Mob337-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob337Concentrated 1ml Clone: ciiy f ylndpnet iae i cl cce s euae b the by regulated is cycle cell in kinases cyclin-dependent of activity Specificity: Cellular Localization: Nuclearmembrane Positive Control: Tonsil Isotype: ABC ie ee netd ih eobnn human recombinant with injected were mice BALB/C Immunogen: Mob340-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob340Concentrated 1ml Clone: d C Cdc C Monoclonal MouseAnti-Human Cdc Monoclonal MouseAnti-Human ------DCS-120 47DC141 IgG2a IgG1 This antibody reacts with a 65 kDa protein known as Cdc25A. The Cdc25A. as known protein kDa 65 a with reacts antibody This hs nioy ecs ih n 0 D poen nw a hCdc47. as known protein kDa 80 an with reacts antibody This BALB/C mice were injected with purified recombinant Cdc25A. Nuclear F F , , P P 40 Formalin fixed paraffin embeddedhumanspleenstainedwithCdk2antibody(Mob341). Formalin fixed paraffin embeddedhumanbrain stainedwithCdk5(Mob342). n bt ck ad yln ae on ascae wt DA n h initiation the in DNA with associated complex found during replication. are A cyclin and cdk2 both and transition G1/S the at maximal is S-phase.to fromG1 A-cdk2 cyclin levelsof The (asisCyclinphases ofthecellcycle andisimportant for A-cdk2) theprogression complexes with cyclins E, D1 and D3. Cyclin E-cdk2 kinase is active in the G1 and S- Specificity: Cellular Localization: Cytoplasmic, nuclear Positive Control: Tonsil Isotype: cdk2 protein. ABC ie ee netd ih hmn recombinant human a with injected were mice BALB/C Immunogen: Mob341-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob341Concentrated 1ml Clone: Cdk Monoclonal MouseAnti-Human rti. d5 ciiy s novd n emnl ifrnito o nuos and neurons of differentiation terminal muscle cells. in involved is activity Cdk5 protein. numerous in present is and cells mammalian tissues. Neuronal noncycling and muscle and cells contain the cycling highest amount both of this in expressed Specificity: Cellular Localization: Cytoplasmic, nuclear Positive Control: Brain Isotype: Immunogen: Mob342-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob342Concentrated 1ml Clone: Cdk Monoclonal MouseAnti-Human ------2B6 DC17 DC34 Bothclones, IgG1 IgG2b This antibody reacts with a 31 kDa protein known as cdk5. Cdk5 is Cdk5 cdk5. as known protein kDa 31 a with reacts antibody This This antibody reacts with a 33 kDa protein known as cdk2. Cdk-2 cdk2. as known protein kDa 33 a with reacts antibody This BALB/C mice were injected with a recombinant cdk5 protein. F F , , P P 2/17/17 5:01PM Primary Antibodies 2/17/17 5:01 PM NEW www.dbiosys.com P P
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(Only for markets outside the U.S. For U.S. market, see index III.) see index market, U.S. For outside the U.S. markets for (Only I Recombinant human CELA3B fragment of 157 amino acid residues acid amino 157 of fragment CELA3B human Recombinant Recombinant protein encoding extracellular domain of human nlike Āother elastase elastases, 3B has little Like elastolytic activity. This antibody recognizes a c-erbB-2 protein, which is a receptor IgG IgG1, kappa IgG1, DBM15.4 SP3 ------Monoclonal Mouse Anti-Human C L L Clone: 1ml Mob478 Concentrated o.: Catalog 10ml PDM222-10MM Prediluted 6ml PDM222 Prediluted Immunogen: (aa82-238). Isotype: Pancreas Control: Positive Cytoplasmic Localization: Cellular Specificity: most of the human elastases, elastase 3B is secreted zymogen from and, the like pancreas other as serine a proteases such has a as digestive kallikrein Āit function trypsin, in the chymotrypsin intestine. Elastase and 3B preferentially cleaves proteins after alanine residues. elastase and 3A Elastase elastase Both cholesterol. of 3B metabolism and transport intestinal may also function in the 3B have been referred to as protease E and as elastase 1, in function and pancreatic of excretion measure of a as used this frequently is material fecal in protein assays. clinical Monoclonal RabbitMonoclonal Anti-Human c er Oncoprotein Clone: 0.5ml Concentrated RMAB008 o.: Catalog egulatory Status: 6ml RMPD008 Prediluted Immunogen: c-erbB2. Isotype: carcinoma Breast Control: Positive membrane Cell Localization: Cellular Specificity: tyrosine kinase of the subset a in c-erbB detectable is oncoprotein c-erbB-2 receptor. family. factor growth epidermal It is closely related in structure of breast and other adenocarcinomas, to as well as transitional cell carcinomas. the In has determined by immunohistochemistry expression cancer, the case of breast prognosis. poor with associated be to shown been egulatory Status: I egulatory Status: Formalin fixed paraffin embedded human pancreas stained with CELA3B/ELA3B paraffin (Mob478). fixed Formalin Formalin fixed paraffin embedded human breast carcinoma stained with c-erbB-2 embedded human breast carcinoma antibody paraffin fixed Formalin (RMAB008). 41 P P
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F Cell membrane Cell I A synthetic peptide corresponding to residues near the C-term of near the C-term A synthetic peptide corresponding to residues Keyhole limpet hemocyanin conjugated synthetic human peptide human synthetic conjugated hemocyanin limpet Keyhole This antibody reacts with the c-erbB-2 oncoprotein, a 190 kDa The caudal-related homeodomain protein 2, Cdx2, is a transcription a is Cdx2, 2, protein homeodomain caudal-related The Rabbit IgG Rabbit EP25 factor which is expressed in the intestine and is thought to play an important role role important an play to thought is and intestine the in expressed is which factor in the proliferation and differentiation of intestinal epithelial protein is expressed in primary and cells. metastatic colorectal carcinomas, intestinal The Cdx2 colorectal human In cancer. gastric type intestinal and stomach the of metaplasia regulated gene a 1, anhydrase carbonic and Cdx2 both of expression the cancer, defining in regulators important the of one is Cdx2 absent. or reduced is Cdx2, by tract. gastrointestinal the in metabolism drug of control coordinate for pathways Immunogen: protein. Cdx2 human Isotype: adenocarcinoma colon Colon, Control: Positive Nuclear Localization: Cellular Specificity: ------Immunogen: oncoprotein. c-erbB-2 from carcinoma Breast Control: Positive Localization: Cellular Specificity: Polyclonal Rabbit Anti-Human Polyclonal c er Oncoprotein Monoclonal RabbitMonoclonal Anti-Human Cdx Clone: 0.5ml Concentrated RMAB059 o.: Catalog I egulatory Status: 6ml RMPD059 Prediluted RP006 Concentrated 1ml RP006 Concentrated o.: Catalog 6ml PDR003 Prediluted egulatory Status: 0.5ml RP006-05 Concentrated protein. The proto-oncogene for c-erbB-2 is located on the human chromosome chromosome human the on located c-erbB-2is for proto-oncogene The protein. 17, band 21. It studies has have indicated structural similarities to EGR. ĀSeveral that c-erbB-2 may in of the prognosis be a good indicator of human carcinomas tract. gastrointestinal and uterus ovary, breast, the Formalin fixed paraffin embedded human breast carcinoma stained with c-erbB-2 embedded human breast carcinoma antibody paraffin fixed Formalin (RP006). Formalin fixed paraffin embedded human colon stained with Cdx2 (RMPD059). embedded human colon paraffin fixed Formalin Page 40-46 Hard Edit.pdf 2 Page 40-46 Hard Edit.pdf 3 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanpancreasstainedwithChromogranin A(RMAB105). Formalin fixed paraffin embeddedhumanplacenta stainedwithhCG antibody(RP007). prolactinomas prolactinomas readily express chromogranin. placenta and placental trophoblasts. RMPD105Prediluted 6ml RMAB105-1 Concentrated 1ml Status: egulatory RMPD105-10RMPrediluted 10ml Catalog o.: RMAB105 Concentrated 0.5ml Clone: yia o nuonorn nolss Ms ptiay dnms and adenomas pituitary Most neoplasms. neuroendocrine is of NSE typical and chromogranin of co-expression The the paraganglioma. raise of should possibility staining anti-keratin of absence and staining chromogranin anti- strong of presence The lineage. neuroendocrine indicates chromogranin and keratins certain of co-expression Reportedly, neoplasms. neuroendocrine in common is (NSE) enolase specific neuron and A chromogranin of expression tumors, carcinoid Co- for tumors. neuroendocrine marker other and paragangliomas, excellent pheochromocytomas, an is It islets. pancreatic and medulla body, including the neuroendocrine cells of the large and small intestine, adrenal Specificity: Cellular Positive Isotype: Immunogen: Chromogranin Anti-Human Monoclonal Rabbit Specificity: Cellular Localization: Cytoplasmic Positive Control: Placenta Immunogen: RP007-05Concentrated 0.5ml Status: egulatory I PDR030Prediluted 6ml Catalog o.: RP007Concentrated 1ml Chorionic onadotropin (hC ) Polyclonal Anti-Human Rabbit ------DBR16.20 .inely Granular Localization: Cytoplasmic . IgG, Kappa Control: Pancreas Chromogranin A is present in neuroendocrine cells throughout the throughout cells neuroendocrine in present is ChromograninA hsatbd ecs ih C. t tis togy ih h human the with strongly stains It hCG. with reacts antibody This Recombinant human chromogranin A protein. β chain of human chorionic gonadotropin. I
F 3 60 F , , P P NEW 42 (PDM067). Formalin fixed paraffin embeddedhumanpancreasstainedwithChromogranin Aantibody (RP008). Formalin fixed paraffin embeddedhumanpancreasstainedwithChromogranin Aantibody RP008-05Concentrated 0.5ml Status: egulatory I Catalog o.: RP008Concentrated 1ml Chromogranin Polyclonal Anti-Human Rabbit neuroendocrine tumors. egulatory Status: egulatory I eredcie el ad erl ise. t os o rcgie h epitopes the recognize not located does on the It N-terminal half tissues.of the chromogranin neural A molecule. and cells neuroendocrine Mob048-05Concentrated 0.5ml PDM067-10MMPrediluted 10ml PDM067Prediluted 6ml Catalog o.: Mob048Concentrated 1ml Clone: ln ad agras ses f aces Ti atbd san a ait of variety a stains antibody This pancreas. of islets Langerhans and gland seen in the secretory granules of parathyroid, adrenal medulla, anterior pituitary is staining positive A neurons. and cells endocrine of variety wide a of granules Specificity: Cellular Localization: Cytoplasmic Positive Control : Pancreas Isotype: Immunogen: Chromogranin Monoclonal MouseAnti-Human Specificity: Cellular Localization: Cytoplasmic Positive Control: Pancreas patients with carcinoid syndrome. Immunogen: ------LK2H10 IgG1, kappa Chromogranin A is a 439 amino acid protein present in secretory secretory in present protein acid amino 439 a is A Chromogranin hs nioy ecs ih ua crmgai A n the in A chromogranin human with reacts antibody This BALB/C mice were immunized with human pheochromocytoma. -emnl af f hoornn ws uiid rm rn of urine from purified was A chromogranin of half C-terminal F 3 60 F , ,
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F I Recombinant human chromogranin A protein. A chromogranin human Recombinant
Chromogranin A is present in neuroendocrine cells throughout the cells throughout in neuroendocrine A is present Chromogranin IgG2b, kappa IgG2b, DBM15.22 ------Polyclonal Rabbit Anti-Human Polyclonal Claudin 1ml RP153 Concentrated o.: Catalog egulatory Status: 0.5ml RP153-05 Concentrated Immunogen: A synthetic peptide corresponding to C-terminal of human Monoclonal Mouse Anti-Human Monoclonal Chromogranin Immunogen: Isotype: pancreas Small intestine, Control: Positive Cytoplasm Localization: Cellular Specificity: tumors, carcinoid marker for body and serves as an excellent tumors. and other neuroendocrine paragangliomas, pheochromocytomas, specific enolase (NSE) is and neuron A Co-expression of chromogranin neoplasms. common in neuroendocrine Clone: 1ml Mob476 Concentrated o.: Catalog I egulatory Status: 6ml PDM191 Prediluted 10ml PDM191-10MM Prediluted claudin 1. claudin skin carcinoma, Breast Control: Positive cytoplasmic membrane, Cell Localization: Cellular Specificity: Claudin 1-8 proteins are a family of transmembrane proteins associated with tight Tight junctionsjunctions. are specialized regions of cell to cell contact, made up of a network of strands to act as a molecular preventing gasket the leakage for of ions, water etc., between They cells. are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. composition. Different claudin different exhibit tissues Formalin fixed paraffin embedded human skin stained with Claudin 1 antibody (RP153). paraffin fixed Formalin Formalin fixed paraffin embedded human pancreas stained with Chromogranin A (Mob476). embedded human pancreas stained with Chromogranin paraffin fixed Formalin 43 P P
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F F Cytoplasmic I Pancreas, neuroendocrine tumors neuroendocrine Pancreas, A synthetic peptide corresponding to residues near the C-terminus the near residues to corresponding peptide synthetic A Recombinant protein encoding human Chromogranin A. Chromogranin human encoding protein Recombinant This antibody recognizes Chromogranin A. Chromogranin A (a Chromogranin A (CgA) is an 86 kDa protein that is the major member major the is that protein kDa 86 an is (CgA) A Chromogranin IgG IgG SP12 EP38 ------Immunogen: protein. A Chromogranin human of Isotype: Control: Positive Localization: Cellular Specificity: of the granin family of acidic secretory glycoproteins located in neurosecretory granules of neuroendocrine cells. Chromogranin A showed broad expression in endocrine tissues including pituitary, adrenal medulla, pancreatic thyroid, islets and gastrointestinaltract. Chromogranin A represents the single most specific marker of neuroendocrine differentiation in general use. Antibody to Monoclonal Rabbit Anti-Human Chromogranin Immunogen: Isotype: Placenta Control: Positive Cytoplasmic Localization: Cellular Specificity: protein protein of 439 amino acid which of is cells encoded neuroendocrine on the chromosome including 14) is body, present the in throughout cells neuroendocrine the large and small intestine, adrenal medulla excellent marker and for pancreatic carcinoid tumors, islets. pheochromocytomas, It paragangliomas, neuron is and A chromogranin of Coexpression an tumors. neuroendocrine other and neoplasms. neuroendocrine in common is (NSE) enolase specific Monoclonal RabbitMonoclonal Anti-Human Chromogranin egulatory Status: I egulatory Status: Clone: 0.5ml Concentrated RMAB015 o.: Catalog 10ml Prediluted RMPD015-10RM 1ml Concentrated RMAB015-1 6ml RMPD015 Prediluted Clone: 0.5ml Concentrated RMAB066 o.: Catalog egulatory Status: 1ml Concentrated RMAB066-1 6ml RMPD066 Prediluted Chromogranin is useful for identification of neuroendocrine tumors. neuroendocrine of identification for useful is Chromogranin Formalin fixed paraffin embedded human pancreas stained with Chromogranin A antibody embedded human pancreas stained with Chromogranin paraffin fixed Formalin (RMAB066). Formalin fixed paraffin embedded human pancreas stained with Chromogranin A antibody with Chromogranin embedded human pancreas stained paraffin fixed Formalin (RMAB015). Page 40-46 Hard Edit.pdf 4 Page 40-46 Hard Edit.pdf 5 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanlungstainedwithClaudin5(RP157). (RP156). Formalin fixed paraffin embeddedhumanovarian carcinoma stainedwithClaudin4antibody tissues exhibit different claudin Differentcomposition. polarity. cell epithelial maintain they where sheets epithelial luminal preventing the leakage of ions, water, etc., between cells. They are abundant in abundant arecells. They water,between ions,etc., forof leakage gasket the preventing molecular a as act to strands of network a of up made contact, cell to cell of regions specialized are junctions. junctions Tighttight with associated Specificity: Specificity: Cellular Localization: Cell membrane, cytoplasmic Positive Control: Lung claudin 5. tissues exhibit Different different polarity. claudin composition. cell epithelial theymaintain where sheets epithelial luminal in abundant are cells. They between etc., water ions, of leakage the preventing RP157-05Concentrated 0.5ml Status: egulatory Catalog o.: RP157Concentrated 1ml RP156-05Concentrated 0.5ml Status: egulatory Catalog o.: RP156Concentrated 1ml snhtc etd crepnig o -emnl f human of C-terminal to corresponding peptide synthetic A Immunogen: Claudin Polyclonal Anti-Human Rabbit Claudin Polyclonal Anti-Human Rabbit cell contact, made up of a network of strands to act as a molecular gasket for gasket molecular a as act to strands of network a of up made contact, cell to cell of regions specialized are junctions. junctions Tighttight with associated Specificity: Cellular Localization: Cell membrane, cytoplasmic Positive Control: variancarcinoma, tonsil claudin 4. Immunogen: ------F lui 18 rtis r a aiy f rnmmrn proteins transmembrane of family a are proteins 1-8 Claudin lui 18 rtis r a aiy f rnmmrn proteins transmembrane of family a are proteins 1-8 Claudin snhtc etd crepnig o -emnl f ua human of C-terminal to corresponding peptide synthetic A I I
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P P 44 Formalin fixed paraffin embeddedhumancolon adenocarcinoma stainedwithc-myc(Mob231). (Mob229). Formalin fixed paraffin embeddedhumanplacenta stainedwithCollagenType IVantibody both components of the p62 and p64 c-myc. with reacts antibody c-myc.This product oncogene human of 410-419 residue Specificity: Cellular Localization: Nuclear Positive Control: Breast carcinoma Isotype: human p62c-myc protein. Mob229-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob229Concentrated 1ml Clone: ytei ppie orsodn t rsde 4849 f the of 408-439 residues to corresponding peptide Synthetic Immunogen: Mob231-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob231Concentrated 1ml Clone: c myc Monoclonal MouseAnti-Human vitronectin, vitronectin, fibronectin or chondroitin sulfate A, B and C. I,II,III, withcollagentypes reactivity V, VI and withhuman VII anddoesnotreact cross- no shows IV.antibody This type collagen human of chains 2 α and/or α1 Specificity: Cellular Localization: Basementmembrane Positive Control: Skin Isotype: Immunogen: Collagen ype I Monoclonal MouseAnti-Human ------C L-94 9E10 IgG1 IgG1 hs nioy eonzs n ptp lctd n h aio acid amino the in located epitope an recognizes antibody This This antibody recognizes collagen type IV epitope located on the F Human collagen type IV. F
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, , F hen its concentrations in the 3 6 0 3 6 0 F A synthetic cyclic peptide from the antigen C-terminus. antigen the from peptide cyclic synthetic A Prokaryotic fusion recombinant protein corresponding to human This antibody is specific to human cyclin D1. The cyclin D1 gene is Cyclins are a family of proteins involved in the progression of cells IgG2a IgG DCS-6 BV2 ------probably probably by causing association a in functions protein and chain regulators, to cycle cell block key the the of enzymatic one is site. bcl-1 Cyclin or PRAD-1D1 or with cdk4 and/or cdk6 by phosphorylating the Rb It proto- protein. is a putative mantle including neoplasms human of variety wide a in overexpressed oncogene (MCL). lymphomas cell Monoclonal Rabbit Anti-Human Cyclin Immunogen: Isotype: carcinoma Breast Control: Positive Nuclear Localization: Cellular Specificity: cyclin-dependent partner its with complex a forms cyclin A cycle. cell the through kinase (cdk), which activates the latter.s protein kinase function. Cyclins are so named because they are produced or degraded as needed in order to drive the stages of the cell cycle. the different cell through cell are low, the cyclin detaches from the cdk, inhibiting the enzyme Monoclonal Mouse Anti-Human Monoclonal Cyclin Clone: 1ml Mob178 Concentrated o.: Catalog 6ml Prediluted PDM046 I egulatory Status: 0.5ml Mob178-05 Concentrated 10ml PDM046-10MM Prediluted Immunogen: D1. cyclin Isotype: carcinoma Breast Control: Positive Nuclear Localization: Cellular Specificity: located on 11q13 and has phase been G1 shown late to to mid in be point amplified critical a in at occurs a D1 cyclinvariety of of expression Maximum tumors. cycle. cell the of Clone: 0.5ml Concentrated RMAB023 o.: Catalog I egulatory Status: 1ml Concentrated RMAB023-1 6ml RMPD023 Prediluted 10ml RMPD023-10RM Prediluted Formalin fixed paraffin embedded human breast carcinoma stained with Cyclin D1 (RMPD023). stained with Cyclin embedded human breast carcinoma paraffin fixed Formalin Formalin fixed paraffin embedded human mantle cell lymphoma stained with Cyclin D1 (Mob178). lymphoma stained with Cyclin embedded human mantle cell paraffin fixed Formalin 45 P P
, , F F BALB/C mice were injected with hamster cyclin B1 protein. B1 cyclin hamster with injected were mice BALB/C A synthetic peptide derived from C-terminus of human cyclin This antibody is specific to a protein of 62 kDa identified as cyclin B1. cyclin as identified kDa 62 of protein a to specific is antibody This In mammals, cyclin B associates with inactive p34cdc2, which IgG1 V152 ------Monoclonal Mouse Anti-Human Cyclin Polyclonal Rabbit Anti-Human Polyclonal Cyclin Cyclin B1 Cyclin expression is restricted to a specific short period of the cell cycle with cyclin before concentration peakingin and earlier detected expression B1 cyclin corresponds B cyclin with staining positive tumors, of majority a In expression. B2 tumor. the of status proliferative the to Immunogen: Isotype: carcinoma Breast Control: Positive Cytoplasmic Localization: Cellular Specificity: Clone: 1ml Mob264 Concentrated o.: Catalog I egulatory Status: 0.5ml Mob264-05 Concentrated Immunogen: RP137 Concentrated 1ml RP137 Concentrated o.: Catalog I egulatory Status: 0.5ml RP137-05 Concentrated B1 protein. B1 carcinoma Breast Control: Positive Cytoplasmic Localization: Cellular Specificity: This maintains the facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. inactive state until the end The of inactive G2-phase. cyclin B-p34cdc2 complex synthesis, DNA of completion the until cytoplasm the in accumulate to continues when cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr 15Tyr and of p34cdc2 rendering the complex active activemitotic kinase until the metaphase/anaphase transition complex remains at the G2/M boundary. This and ubiquitin-dependent is process degradation This degraded. is B cyclin when in role critical a plays B-p34cdc2 cyclin So, mitosis. exit to cell the necessaryfor is transition. M to G2 Formalin fixed paraffin embedded human breast carcinoma stained with Cyclin B1 (Mob264). stained with Cyclin embedded human breast carcinoma paraffin fixed Formalin Formalin fixed paraffin embedded human breast carcinoma stained with Cyclin B1 antibody stained with Cyclin embedded human breast carcinoma paraffin fixed Formalin (RP137). Page 40-46 Hard Edit.pdf 6 Page 40-46 Hard Edit.pdf 7 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithCyclin D1(RMAB003). Formalin fixed paraffin embeddedhumantonsilstainedwithCyclin D1(RP120). Immunogen: RP120-05Concentrated 0.5ml Status: egulatory I Catalog o.: RP120Concentrated 1ml RMPD003-10RMPrediluted 10ml RMPD003Prediluted 6ml Status: egulatory I Catalog o.: RMAB003 Concentrated 0.5ml Clone: cell mantle including neoplasms human lymphomas (MCL). of variety wide a in overexpressed putativeproto-oncogene a is protein.It Rb the phosphorylating by cdk6 and/or cdk4 with association in functions and regulators cycle cell key the of one is 1 Specificity: Cellular Localization: Nuclear Positive Control: Breast carcinoma, mantlecelllymphoma neoplasms Rb including mantle the cell lymphomas (MCL). phosphorylating by cdk6 protein. and/or It is a cdk4 putative proto-oncogene overexpressed with in a wide association variety of human in functions Specificity: Cellular Localization: Nuclear Positive Control: Breast carcinoma Isotype: Immunogen: Cyclin Anti-Human Monoclonal Rabbit Cyclin cl Polyclonal Anti-Human Rabbit ------SP4 IgG This antibody reacts with a 36 kDa protein. Cyclin D1 or PRAD-1 or bcl- Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell cycle regulators, and A synthetic peptide from C-terminus of human cyclin D1. A synthetic peptide from C-terminus of human cyclin D1.
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P P NEW 46 Formalin fixed paraffin embededhumanbreastcarcinoma stainedwithCyclin Eantibody(Mob266). (Mob181). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithCyclin Eantibody is modulated by the presence of tumor suppressor proteins such as p16. is mediated through its activation of cyclin dependent kinase 2 (cdk2) protein and presence of tumor suppressor proteins such as p16. the by modulated is and protein (cdk2) 2 kinase dependent cyclin of activation accelerating progression of S phase. The activity of cyclin E is mediated through its Specificity: Cellular Localization: Nuclear Positive Control: Breast carcinoma Isotype: molecule. length of the G1 phase, accelerating progression the shortens E of verexpressioncyclin of S phase. The activity of . cycle.cyclin cell eukaryotic the E progressionof Specificity: Cellular Localization: Nuclear Positive Control: Breast carcinoma Isotype: E molecule. ytei ppie orsodn t te ul egh cyclin length full the to corresponding peptide Synthetic Immunogen: PDM145Prediluted 6ml Mob266-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob266Concentrated 1ml Clone: Cyclin Protein Monoclonal MouseAnti-Human Immunogen: Mob181-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob181Concentrated 1ml Clone: Cyclin Protein Monoclonal MouseAnti-Human ------13A3 HE12 IgG2a,kappa IgG2a, kappa verexpression of cyclin E shortens the length of the G1 phase, G1 the of length the shortens E cyclin of verexpression Cyclin proteins are a family of related proteins, which control the control which proteins, related of family a are proteins Cyclin ytei ppie orsodn t te ul egh yln E cyclin length full the to corresponding peptide Synthetic
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P , , F (Only for markets outside the U.S. For U.S. market, see index III.) see index market, U.S. For outside the U.S. markets for (Only I BALB/C mice were immunized with recombinant protein encoding encoding protein recombinant with immunized were mice BALB/C Human Cystatin A. Cystatin Human This antibody reacts with 11-13 kDa protein, Cystatin A. Cystatins A. Cystatins Cystatin with 11-13 kDa protein, This antibody reacts This antibody reacts with a protein of 165-170 kDa. Cystic fibrosis IgG1 IgG1 M3A7 WR-23/2/3/3 ------Immunogen: CFTR. human of domain NBF2 Isotype: Pancreas Control: Positive membrane Cell Localization: Cellular Specificity: transmembrane regulator (CFTR) is composed domains (MSD), two nucleotide-binding domains (NBD) and one of R domain. It is two membrane-spanning structurally similar to multidrug resistance protein (Mdr1). CFTR is found in the apical membranes of duct pancreatic epithelia human within of marker the valuable pancreas, a intestine, is bile CFTR ducts. duct, genital sweat male and gland differentiation. and development cell Monoclonal Mouse Anti-Human ransmem rane Fi rosis Cystic F (CF ) egulator Monoclonal Mouse Anti-Human Monoclonal Cystatin Immunogen: Isotype: : Brain Control Positive Cytoplasmic Localization: Cellular Specificity: Clone: 1ml Mob378 Concentrated o.: Catalog egulatory Status: 0.5ml Mob378-05 Concentrated Clone: 1ml Mob409 Concentrated o.: Catalog I egulatory Status: 0.5ml Mob409- 05 Concentrated a superfamily, that form endogenous inhibitors of lysosomal proteases are A is thought to be a tumor Cystatin which is classified into 1, 2, and 3 families. of level the between seems to exist correlation since an inverse suppressor, A has been implicated in aging of Cystatin A and tumor progression. Cystatin and inflammatory viral infection processes. Alzheimer's disease, tissues, Formalin fixed paraffin embedded human pancreas stained with CFTR antibody (Mob378). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with Cystatin A antibody (Mob409). embedded human tonsil stained with Cystatin paraffin fixed Formalin 47 P P , , F F 3 6 0 Recombinant protein corresponding to C-terminus of rat COX2. rat of C-terminus to corresponding protein Recombinant Synthetic peptide corresponding to C-terminus of COX2. of C-terminus to corresponding peptide Synthetic COX-2 (Cyclooxygenase-2) COX-2 is an inducible enzyme. It is involved in This antibody reacts with a 70 kDa protein. COX-2 (Cyclooxygenase- COX-2 protein. kDa 70 a with reacts antibody This IgG SP21 ------Immunogen: and colon carcinoma Lung Control: Positive membrane Cytoplasmic, Localization: Cellular Specificity: Polyclonal Rabbit Anti-Human Polyclonal (CO ) Cyclooxygenase Immunogen: Isotype: colon carcinoma carcinoma, Lung Control: Positive membrane Cytoplasmic, Localization: Cellular Specificity: the response of cells to growth factors, tumor promoters, and induce cytokines its that expression. Given its role in of is in interest induced therefore synthesizing studying immune response regulation. COX-2 prostaglandins, COX-2 is growth immediate-early as identified initially was and stimuli of variety wide a by Monoclonal RabbitMonoclonal Anti-Human (CO ) Cyclooxygenase Clone: 0.5ml Concentrated RMAB006 o.: Catalog 6ml RMPD006 Prediluted 10ml RMPD006-10RM Prediluted egulatory Status: I egulatory Status: 2) is an inducible enzyme. It is involved in the response of cells to growth factors, factors, growth to cells of response the in involved is Itenzyme. inducible an is 2) tumor promoters and cytokines that induce its expression. COX-2 markedly expression increased in 85-90 Ā of human unchanged. remained colorectal levels adenocarcinoma COX-1 whereas RP111 Concentrated 1ml RP111 Concentrated o.: Catalog I egulatory Status: 0.5ml RP111-05 Concentrated response response gene. In addition, expression COX-2 markedly increased in 85-90 Āunchanged. remained of levels COX-1 whereas adenocarcinoma colorectal human Formalin fixed paraffin embedded colon carcinoma stained with COX-2 antibody (RP111). stained with COX-2 carcinoma embedded colon paraffin fixed Formalin Formalin fixed paraffin embedded colon carcinoma stained with COX-2 antibody (RMAB006). stained with COX-2 carcinoma embedded colon paraffin fixed Formalin Page 47-51 Hard Edit.pdf 1Page 47-51 Hard Edit.pdf 1 Page 47-51 Hard Edit.pdf 2 Primary Antibodies www.dbiosys.com Acidic (RMAB087). Formalin fixed paraffin embeddedhumanlungsquamous cell carcinoma stainedwithCytokeratin, Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin antibody(PDM116). egulatory Status: egulatory I f 65 5, 1 5, 0 4, 6 4, n 4ka Mn suis ae hw the shown have studies Many 40kDa. and 45, usefulness 46, of keratins 48, as markers 50, in cancer 50, research 51, and tumor 55, diagnosis. 56.5, of into acidic (pI >6.0) subfamilies. The acidic keratins have molecular weights (MW) electrophoresis gel two-dimensional with resolved are keratins human Twenty and ducts gland mammary tracheal epithelium. epidermis, like epithelia, squamous stratified to pattern of reactivity with human epithelial tissues from simple glandular epithelia
RMAB087-1 Concentrated 1ml Catalog o.: RMAB087 Concentrated 0.5ml Clone: PDM116-10Prediluted 10ml PDM116Prediluted 6ml Mob052-05Concentrated 0.5ml Catalog o.: Mob052Concentrated 1ml Clone: 48kDa (CK16); 40kDa (CK19) keratins of the acidic (Type I or LMW) subfamily. LMW) or I (Type acidic the of keratins (CK19) 40kDa (CK16); 48kDa Specificity: Cellular Positive Isotype: Immunogen: Status: egulatory Cytokeratin, cidic Anti-Human Monoclonal Rabbit through 58kDa, corresponding to cytokeratins 5, 6, 8, 17 and 19. It shows a broad Specificity: Cellular Localization: Cytoplasmic Positive Control: Skin Isotype: from anudemouseengraftedwithMCF-7cells. Immunogen: Cytokeratin Monoclonal MouseAnti-Human ------DBR16.5 MNF116 Localization: Cytoplasmic IgG IgG1,kappa Control: Squamous lung carcinoma This MAb recognizes the 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); This antibody recognizesThis antibody ranging from 40 polypeptides cytokeratin RMAB087-10RM Prediluted 10ml RMAB087 Prediluted 6ml Recombinant human KRT77 protein. BALB/Cmicewere ofspleniccells immunizedwithcrudeextract I
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P P NEW 48 AE1 (PDM043). Formalin fixed paraffin embeddedhumanlungsquamouscell carcinoma stainedwithCytokeratin AE1/AE3 (PDM072). Formalin fixed paraffin embeddedhumanlungsquamouscell carcinoma stainedwithCytokeratin epithelial origin. D031M rdltd1m PDM043-10MMPrediluted 10ml PDM043Prediluted 6ml Status: egulatory I Catalog o.: Mob092Concentrated 1ml Clone: D021M rdltd1m Mob190-05Concentrated 0.5ml PDM072-10MMPrediluted 10ml PDM072Prediluted 6ml Catalog o.: Mob190Concentrated 1ml Clone: itnt el aes n n pteil ise n vros epam of neoplasms various and tissue epithelial an in layers cell distinct stain to used be can layers.antibody This basal the above cells the in present is kDa keratin is present in the basal and suprabasal layers, while 65 to 67 kDa present keratin in the basal layer, while 56.5 kDa keratin is keratin is kDa present 50 epidermis, keratinized in In suprabasal kDa. layers.67 to 64 58 and 59 58, 56.5, 54, 52, keratins as well as basic recognizesII). (Type It keratin polypeptides of 40, 48, 50, Specificity: Cellular Localization: Cytoplasmic Positive Control: tonsil Skin, an in layers epithelial cell tissue and distinct various stain neoplasms in to of epithelial present used origin. be is can keratin antibody kDa This layers. 56.5 suprabasal while layer, basal the in present is keratin kDa recognizes keratinpolypeptidesof50and56.5kDa.In keratinizedepidermis, 50 Specificity: Cellular Localization: Cytoplasm Positive Control: Skin Isotype Immunogen: Cytokeratin , cidic Isotype: Immunogen: Cytokeratin Monoclonal MouseAnti-Human egulatory Status: egulatory I Monoclonal MouseAnti-Human ------A 1 A 1 A 3 : IgG1,kappa A 1, IgG1, kappa; A 3,IgG1, k A 1,IgG1,kappa; This It keratins. I) (Type acidic the of most recognizes antibody This BALB/Cmicewere immunizedwithhumanepidermalkeratin. BALB/Cmicewere immunizedwithhumanepidermalkeratin. A 1/A 3 antibody cocktail recognizes most of the acidic (Type I) F appa 360 360 F , ,
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IVD CK5: A synthetic peptide corresponding to residues near the to residues CK5: A synthetic peptide corresponding BALB/C mice were injected with cytokeratin 5. BALB/C mice were Cytokeratin Cytokeratin 5 (58 kDa) is a high molecular weight, basic type of CK5 labels myoepithelial cells of breast and prostate basal cells. CK6 is CK6 cells. basal prostate and breast of cells myoepithelial labels CK5 Rabbit IgG IgG1, kappa D5/16 B4 P24/ P67 ------Cytokeratin 5/6 Cocktail 5/6 Cocktail Cytokeratin Immunogen: protein. C-terminus of human CK-5 on the C-terminus of to residues CK6: A synthetic peptide corresponding protein. human CK-6 Isotype: mesothelioma squamous cell carcinoma, lung Prostate, Control: Positive Cytoplasmic Localization: Cellular Specificity: Monoclonal Mouse Anti-Human Monoclonal 5/6 Cytokeratin Immunogen: Isotype: Skin Control: Positive Cytoplasmic Localization: Cellular Specificity: stratified of layers cell superficial and intermediate basal, in expressed cytokeratin epithelia as well as transitional epithelia, complex epithelia and in mesothelial cells and mesothelioma. 6 Cytokeratin (56 kDa) is also a high molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium 16. cytokeratin often with paired Clone: 1ml Mob362 Concentrated No.: Catalog 6ml Prediluted PDM123 10ml Prediluted PDM123-10MM Regulatory Status: 0.5ml Mob362-05 Concentrated Clone: 0.5ml Concentrated RMAB055 No.: Catalog IVD Regulatory Status: 6ml RMPD055 Prediluted Monoclonal Rabbit Anti-Human expressed onexpressed stratified epithelia including oral mucosa, esophagus, basal oflayer epidermis, the outer root sheath of hair follicles, and in glandular epithelia. CK6 is a is CK6 epithelia. glandular in and follicles, hair of sheath root outer the epidermis, marker of and hyperproliferative activated keratinocytes found in psoriasis. Anti- CK6 paired with the CK5 antibody is useful for differentiating mesothelioma (positive) from lung carcinoma (negative) or metastatic carcinoma (negative) in the in (negative) carcinoma metastatic or (negative) carcinoma lung from (positive) pleura. An antibody against CK5/6 has also been used to distinguish usual ductal hyperplasia of the breast (strong staining) from solid papillary DCIS (negative). DCIS papillary solid from staining) (strong breast the of hyperplasia Formalin fixed paraffin embedded squamous lung carcinoma stained with CK 5/6 antibody embedded squamous lung carcinoma paraffin fixed Formalin (RMAB055). Formalin fixed paraffin embedded lung squamous cell carcinoma stained with Cytokeratin 5/6 stained with Cytokeratin carcinoma embedded lung squamous cell paraffin fixed Formalin (PDM123). 49 H H P P
,/ ,/ F 3 6 0 3 6 0 F BALB/C mice were injected with prokaryotic recombinant protein recombinant prokaryotic with injected were mice BALB/C BALB/C mice were immunized with human epidermal keratin. BALB/C mice were This antibody recognizes basic (Type II or HMW) cytokeratins, which cytokeratins, HMW) or II (Type basic recognizes antibody This IgG1, kappa IgG1, kappa XM26 A 3 ------Immunogen: to 103 amino acid portion of the human corresponding of C-terminal region cytokeratin 5 molecule. Isotype: Skin Control: Positive Cytoplasmic Localization: Cellular Specificity: This antibody reacts with cytokeratin 5 intermediate filament Monoclonal Mouse Anti-Human 5 Cytokeratin includes 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 56kDa (CK5); 58kDa (CK4); 59kDa (CK3); 64kDa (CK1); 67kDa includes 52kDa and 56, 58, 59, 64, 65-67, recognizes antibody This (CK8). 52kDa of usefulness the shown have studies Many subfamily. basic of keratins diagnosis. tumor and research cancer in markers as keratins Immunogen: Isotype: squamous cell carcinoma Lung Control: Positive Cytoplasm Localization: Cellular Specificity: Monoclonal Mouse Anti-Human Monoclonal AE3, Basic Cytokeratin Clone: 1ml Mob361 Concentrated No.: Catalog 6ml PDM139 Prediluted 10ml PDM139-10MM Prediluted 0.5ml Mob361-05 Concentrated Regulatory Status: IVD Regulatory Status: Clone: 0.5ml Mob093 Concentrated No.: Catalog 6ml PDM044 Prediluted 10ml PDM044-10MM Prediluted protein. protein. Basal cells of human epidermis express acidic cytokeratin 14 and basic cytokeratin 5. Cytokeratin 5 is a 58 kDa protein, which is closely related to IVD Regulatory Status: cytokeratin 6. 5 Cytokeratin and 6 are expressed in basal cell epithelioma, basal cells of urothelium, prostate, vagina, squamous cell carcinomas of skin, tongue, of distinction the in useful be can 5 Cytokeratin region. rectal-anal and epiglottis adenocarcinomas. most from mesotheliomas Formalin fixed paraffin embedded human colon stained with Cytokeratin 5 (Mob361). stained with Cytokeratin embedded human colon paraffin fixed Formalin Formalin fixed paraffin embedded lung squamous cell carcinoma stained with Cytokeratin AE3 stained with Cytokeratin carcinoma embedded lung squamous cell paraffin fixed Formalin (Mob093). Page 47-51 Hard Edit.pdf 3 Page 47-51 Hard Edit.pdf 4 Primary Antibodies www.dbiosys.com (Mob532). Formalin fixed paraffin embeddedhumansquamouslungcarcinoma stainedwithCytokeratin 6 Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin 5/14(Mob433). cell carcinomas. CK6 and CK16. CK6 is strongly expressed in about head 75 Āof and neck squamous situations. pidermal Āinjury results in activation of keratinocytes, which expresskeratinocytes, which of activation situations.pidermal Āinjuryin results hyper-proliferativeand normal both epidermis,in stratifiedinternalepithelia, in PDM140Prediluted 6ml Mob433-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob433Concentrated 1ml Clone: Specificity Cellular Localization: Cytoplasm Postive Control: Tonsil Isotype Immunogen PDM267Prediluted 6ml Status: egulatory PDM267-10MMPrediluted 10ml Catalog o.: Mob532Concentrated 1ml Clone: Cytokeratin Monoclonal MouseAnti-Human to distinguish useful stratified epithelial be cells can from antibody simple This epithelial 15. cells. cytokeratin with combination in exists and cytokeratins MW low of subfamily (acidic) A type the to belongs Cytokeratin14 mesotheliomas from most adenocarcinomas. epiglottis andrectal-anal region. Cytokeratin5 canbeusefulinthedistinction of to tongue, skin, of carcinomas cell squamous vagina, relatedprostate,urothelium, of cells closely is which protein, basal epithelioma, cell kDa basal in expressed are 6 basic and Cytokeratin5 6. 58 cytokeratin and a 14 is cytokeratin 5 Cytokeratin acidic 5. express cytokeratin epidermis human of cells Basal 14. filament protein as well as the 50 kDa cytokeratin protein designated cytokeratin Specificity: Cellular Localization: Cytoplasmic Positive Control: tonsil Skin, Isotype: LL002: Synthetic peptide of the extreme molecule. 5 C-terminal cytokeratin of human human the keratin-14. of region C-terminal of portion acid amino Immunogen: Cytokeratin Monoclonal MouseAnti-Human ------DBM15.58 XM26 LL002 : IgG2a,kappa XM26,IgG1;LL002,IgG3 Krtn i fud n ar olce, urbsl el o a ait of variety a of cells suprabasal follicles, hair in found is 6 Keratin : hs nioy okal ecs ih yoeai 5 intermediate 5 cytokeratin with reacts cocktail antibody This : Recombinanthumankeratin6protein M6 poaytc eobnn poen orsodn t 103 to corresponding protein recombinant prokaryotic XM26: xpr ession of CK6 is particularly associated with differentiation. I
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P P NEW 50 Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin 6/18antibody(Mob051). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithCytokeratin 7(RMAB096). and shows no colon, cross-reaction of with other IFPs. not but breast and prostate, lung, or gastrointestinal tract. ovary, This antibody is highly specific of to cytokeratin 7 cells epithelial the in expressed Mob051-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob051Concentrated 1ml Clone: RMPD096-10RMPrediluted 10ml RMPD096Prediluted 6ml RMAB096-1 Concentrated 1ml Status: egulatory I Catalog o.: RMAB096 Concentrated 0.5ml Clone: h ietfcto o tmr el a big f pteil r es omny of commonly less or epithelial of being mesothelial origin. as cells tumor of identification the in value of is antibody epithelia. This squamous stratified to epithelia glandular simple from tissues epithelial human with reactivity of pattern broad a shows Specificity: Cellular Localization: Cytoplasmic Positive Control: Skin Isotype: Immunogen: Cytokeratin Monoclonal MouseAnti-Human rniinl ptei bt o i te taiid qaos ptei. K is CK7 epithelia. squamous stratified the in not but epithelia transitional and glandular to confined is distribution its subfamily,and B type neutral-basic belongstothe cells. CK7,a54kDaprotein, inalmostalleukaryotic cytoskeleton Specificity: Cellular Positive Isotype: Immunogen: Cytokeratin Anti-Human Monoclonal Rabbit ------LP34 DBR16.11 Localization: Cytoplasm IgG1,kappa IgG Control: Breast carcinoma, lung carcinoma This antibody recognizes keratin polypeptides of 45 and 56 kDa. It It kDa. 56 and 45 of polypeptides keratin recognizes antibody This Cytokeratin 7belongstotheintermediatefilaments, whichcreate a Recombinant full-length human KRT7 protein BALB/C micewere immunizedwithhumankeratin. F F 3 60 , ,
P P NEW 2/17/17 5:02PM Primary Antibodies 2/17/17 5:02 PM www.dbiosys.com E P ,/ E P
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IVD Cytokeratins from the human breast carcinoma cell line MCF-7. carcinoma the human breast from Cytokeratins BALB/C mice were immunized with cytoskeletalextract of BALB/C mice were This antibody is specific to human cytokeratins 8 (52.5 kDa) and 18 This antibody recognizes keratin polypeptide of 54 kDa. It stains stains keratin polypeptide of 54 kDa. It recognizes This antibody IgG1 IgM, kappa 5D3 35 H11 ------Immunogen: Isotype: Skin Control: Positive Cytoplasmic Localization: Cellular Specificity: can antibody This epithelium. glandular and simple stains antibody This kDa). (45 be useful for the identification of adenocarcinomas and most carcinomas. squamous cell Monoclonal Mouse Anti-Human 8/18 Cytokeratin Monoclonal Mouse Anti-Human Monoclonal Weight Molecular 8, Low Cytokeratin Immunogen: Hep3B. cell line, human hepatocellular carcinoma Isotype: Skin, colon Control: Positive Cytoplasmic Localization: Cellular Specificity: but does not stain squamous with non-squamous epithelium strongly epithelium. It gland and ducts reacts in the skin. with the sweat of ductal tract, carcinoma gastrointestinal of the ovary, Adenocarcinomas with this antibody. and bile ducts, stain positive pancreas breast, Clone: 1ml Mob189 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob189-05 Concentrated 6ml PDM070 Prediluted 10ml PDM070-10MM Prediluted Clone: 1ml Mob054 Concentrated No.: Catalog 6ml Prediluted PDM117 10ml Prediluted PDM117-10MM Regulatory Status: 0.5ml Mob054-05 Concentrated Formalin fixed paraffin embedded human colon adenocarcinoma stained with Cytokeratin 8/18 stained with Cytokeratin adenocarcinoma embedded human colon paraffin fixed Formalin antibody (PDM070). Formalin fixed paraffin embedded human colon stained with Cytokeratin 8, Low Molecular 8, Low stained with Cytokeratin embedded human colon paraffin fixed Formalin antibody (PDM117). Weight 51 H H P P
,/ ,/ 3 6 0 F F A synthetic peptide corresponding to residues near the N-term near the N-term to residues A synthetic peptide corresponding BALB/C mice were immunized with ovarian carcinoma cell line, line, cell immunized with ovarian carcinoma BALB/C mice were Cytokeratin 7 (CK7) is a cytoplasmic intermediate filament protein This antibody recognizes keratin polypeptide of 54 kDa. It stains a Rabbit IgG IgG1, kappa P16 -TL 12/30 O -TL ------Immunogen: of human CK7 protein. Isotype: Salivary lung adenocarcinoma gland, Control: Positive Cytoplasmic Localization: Cellular Specificity: expressed on most ductal and glandular bladder and female epithelium genital tract, but including not in lung, most gastrointerstinal epithelium, breast, prostate, hepatocyte and squamous epithelium. CK7 expression colon is cancer, absent prostate in cancer and squamous carcinomas. The restricted Monoclonal Rabbit Anti-Human 7 Cytokeratin Clone: 0.5ml Concentrated RMAB063 No.: Catalog IVD Regulatory Status: 6ml RMPD063 Prediluted Immunogen: OTN11. Isotype: Skin, lung Control: Positive Cytoplasmic Localization: Cellular Specificity: number of epithelial cells including ductal and glandular squamous epithelia epithelia. are positive but transitional Stratified epithelium of the urinary tract does carcinomas. not cell squamous with react not show does but carcinomas cell any transitional staining. This antibody labels adenocarcinomas and Monoclonal Mouse Anti-Human Monoclonal 7 Cytokeratin Clone: 1ml Mob057 Concentrated No.: Catalog 0.5ml Mob057-05 Concentrated 6ml PDM097 Prediluted 10ml PDM097-10MM Prediluted Regulatory Status: IVD Regulatory Status: expression of CK7 in some epithelium makes it useful to identify the organ origin organ the identify to useful it makes epithelium some in CK7 of expression of adenocarcinomas when combined with staining of anti-Cytokeratin 20 and markers. specific cell other Formalin fixed paraffin embedded human lung adenocarcinoma stained with Cytokeratin 7 stained with Cytokeratin embedded human lung adenocarcinoma paraffin fixed Formalin antibody (RMPD063). Formalin Formalin fixed paraffin embedded human lung adenocarcinoma stained with 7Cytokeratin antibody (PDM097). Page 47-51 Hard Edit.pdf 5 Page 52-56 Hard Edit.pdf 1 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanskinstainedwithCytokeratin 10antibody(Mob185). Formalin fixed paraffin embeddedhumanskinstainedwithCytokeratin 10antibody(Mob055). ifrnitd ra o sumu crioa. hs nioy s sfl n the in useful is antibody differentiation of stratified This squamous carcinomas.epithelia. squamous of areas differentiated ptei, urbsl aes f o-eaiiig taiid ptei ad in and epithelia stratified stratified non-keratinizing keratinizing of layers of suprabasal layers epithelia, suprabasal in found protein cytokeratin kDa Specificity: Cellular Localization: Cytoplasmic Positive Control: Skin Isotype: component of trypsin-split normal adult skin. Immunogen: Status: egulatory I antibody. this with negative are adenocarcinomas and epithelium transitional epithelia, suprabasal cells in the epidermis, thymic Hassall’s bodies. Simple and glandular Specificity: Cellular Localization: Cytoplasmic Positive Control: Skin Isotype: of humanepidermis. rd ctseea etat rprd rm h epidermal the from prepared extract cytoskeletal Crude Immunogen: Status: egulatory I Mob185-05Concentrated 0.5ml Catalog o : Mob185Concentrated 1ml Clone: Mob055-05Concentrated 0.5ml Catalog o : Mob055Concentrated 1ml Clone: Cyto eratin Monoclonal MouseAnti-Human Cyto eratin Monoclonal MouseAnti-Human ------LHP1 D - 10 IgG1,kappa IgG1,kappa This antibody is specific to human cytokeratin 10. It recognizes a 56.5 This antibody recognizes keratin polypeptide of 56.5 kDa. It stains BALB/Cmicewere immunizedwithdetergent insolubleextract 360
P P 52 (Mob056). Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin 10/13antibody Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin 13antibody(Mob443). keratinized epidermis. lde, coevx tnu, spau, nl aa ad h bsl ae of layer basal the and canal anal esophagus, tongue, ectocervix, bladder, glands, sweat trachea, This of carcinomas of identification the for myoepithelium. useful is squamous, antibody and in epithelium expressed transitional is epithelium, 13 nonkeratinized Cytokeratin 4. cytokeratin with combination in exists and cytokeratins weight molecular low of subfamily (acidic) A type the Specificity: Cellular Localization: Cytoplasmic Positive Control: Skin Isotype: the vulva. Immunogen: Mob443-05Concentrated 0.5ml Status: egulatory I Catalog o : Mob443Concentrated 1ml Clone: carcinoma. Thisantibody does not stain intraepithelial neoplasm and invasive squamous cell tongueandesophagus. stratifiedepitheliaofvagina,ectocervix, non-cornifying thymicHassall’sepidermis, the in cells suprabasal stains and urotheliumbodies, Specificity: Cellular Localization: Cytoplasmic Positive Control: tonsil Skin, Isotype: of humanepidermis. Immunogen: Mob056-05Concentrated 0.5ml Status: egulatory I PDM241Prediluted 6ml Catalog o : Mob056Concentrated 1ml Clone: Cyto eratin Monoclonal MouseAnti-Human Cyto eratin Monoclonal MouseAnti-Human ------ S-1A3 D - 13 IgG1 IgG2a,kappa This antibody is specific to 54 kDa protein. Cytokeratin 13 belongs to This antibodyrecognizes keratinpolypeptidesof53and56.5kDa.It BALB/Cmicewere immunizedwithdetergent insolubleextract utrd 41 el fo a ua eiemi crioa of carcinoma epidermoid human a from cells A431 Cultured
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,/ ,/ F F Cytoskeletal fraction of rat colon epithelium. Cytoskeletal BALB/C mice were injected with a synthetic peptide from the This antibody is specific to 46 kDa cytokeratin protein designated protein cytokeratin kDa 46 to specific is antibody This This antibody is specific to a 48 kDa protein, which is identified as IgG2b, kappa IgG2b, IgG1 LL025 3 ------Monoclonal Mouse Anti-Human Cytokeratin 17 Cytokeratin Immunogen: Isotype: Skin Control: Positive Cytoplasmic Localization: Cellular Specificity: cytokeratin17. It reacts with basal cells in epithelia complex and reacts strongly carcinomas. cell squamous with Cytokeratin 16 Cytokeratin Clone: 1ml Mob273 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob273-05 Concentrated Immunogen: 16. cytokeratin human of C-terminus Isotype: Skin, squamous cell carcinoma Control: Positive Cytoplasmic Localization: Cellular Specificity: cytokeratin 16. Cytokeratin 16 is expressed in keratinocytes, which are Clone: 1ml Mob127 Concentrated No.: Catalog 0.5ml Mob127-05 Concentrated IVD Regulatory Status: Monoclonal Mouse Anti-Human Monoclonal undergoing undergoing rapid turnover in the suprabasal region. found High between concordance the was carcinomas immunostaining with keratins. the hyperproliferation-related basal cell and the Formalin Formalin fixed paraffin embedded human lung squamous cell carcinoma stained with 17 Cytokeratin Formalin fixed paraffin embedded human tonsil stained with Cytokeratin 16 antibody (Mob273). embedded human tonsil stained with Cytokeratin paraffin fixed Formalin antibody (Mob127). 53 H H P P
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IVD A 17-mer synthetic peptide from the C-terminus of human A 17-mer synthetic peptide from A synthetic peptide of 15 aa residues from the C-terminus of from A synthetic peptide of 15 aa residues Mob305-05 Concentrated 0.5ml Mob305-05 Concentrated Cytokeratin 15 is a type I cytokeratin without a defined type II partner. partner. II type defined a without cytokeratin I type a is 15 Cytokeratin This antibody is specific to 50 kDa cytokeratin protein designated protein cytokeratin kDa 50 to specific is antibody This IgG2a, kappa IgG3 LL002 LH 15 ------Regulatory Status: Regulatory Status: Immunogen: cytokeratin 15. Isotype: Skin Control: Positive Cytoplasmic Localization: Cellular Specificity: Cytokeratin 15 is nail. expressed fetal and primarily epidermis fetal in the including the tissues, basal keratinocytes of stratified Monoclonal Mouse Anti-Human 15 Cytokeratin Immunogen: human keratin 14. Isotype: Skin, squamous cell carcinoma Control: Positive Cytoplasmic Localization: Cellular Specificity: Regulatory Status: IVD Regulatory Status: cytokeratin 14. Cytokeratin 14 belongs This to 15. the cytokeratin typewith combination A in (acidic) exists subfamily and cytokeratins of weight low molecular antibody can be used cells. to epithelial distinguish stratified epithelial cells from simple Clone: 1ml Mob186 Concentrated No.: Catalog 10ml Prediluted PDM138-10MM 0.5ml Mob186-05 Concentrated 6ml PDM138 Prediluted Monoclonal Mouse Anti-Human Monoclonal 14 Cytokeratin Clone: 1ml Mob305 Concentrated No.: Catalog
Formalin fixed paraffin embedded human skin stained with Cytokeratin 15 antibody (Mob305). embedded human skin stained with Cytokeratin paraffin fixed Formalin Formalin fixed paraffin embedded lung squamous cell carcinoma stained with Cytokeratin 14 stained with Cytokeratin carcinoma embedded lung squamous cell paraffin fixed Formalin antibody (Mob186). Page 52-56 Hard Edit.pdf 2 Page 52-56 Hard Edit.pdf 3 Primary Antibodies www.dbiosys.com (Mob187). Formalin fixed paraffin embeddedhumancolon carcinoma stainedwithCytokeratin 18antibody (Mob053-01). Formalin fixed paraffin embeddedhumancolon carcinoma stainedwithCytokeratin 18antibody carcinomas. Regulatory Status:Regulatory IVD pteil ein a wl a a aoiy f dncrioa ad aa cell basal and adenocarcinomas of malignant majority and a benign as with well reacts as lesions It epithelial epithelium. squamous with react not does antibody epithelia. This glandular and ductal simple most in 8 cytokeratin Cytokeratin 18 belongs to a family of acidic type A keratins and exists along with malignant and benign and carcinomas epithelial lesions cell stain with this basal antibody. adenocarcinomas, the of glandular epithelia. This antibodydoesnotreact withsquamousepithelia.Most tissues, it reacts with a large number of epithelial cell types, including ductal and Specificity: Cellular Localization: Cytoplasmic Positive Control: Skin Isotype: Clone: Mob187-05Concentrated 0.5ml PDM164-10MMPrediluted 10ml PDM164Prediluted 6ml Catalog No.: Mob187Concentrated 1ml Clone: PDM068Prediluted 6ml Mob053-01-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob053-01Concentrated 1ml Clone: hs nioy s pcfc o ua ctkrtn 8 f 5 kDa. 45 of 18 cytokeratin human to specific is antibody This Specificity: Cellular Positive Isotype: cell line. Immunogen: Cytokeratin 18 Monoclonal MouseAnti-Human Immunogen: Cytokeratin 18 Monoclonal MouseAnti-Human ------C DC10 C -90 Localization: Cytoplasmic IgG1,kappa IgG1 Control: -90 This antibody recognizes keratin polypeptide of 45 kDa. In normal human breast cancer cells. cancer breast human MC -7 and carcinoma epidermal Human BALB/C mice were injected with PMC-42 human breast carcinoma Skin F F 360 ,/ ,/
P P H E 54 (Mob274). Formalin fixed paraffin embeddedhumancolon carcinoma stainedwithCytokeratin 19antibody (RMAB060). Formalin fixed paraffin embeddedhumancolon carcinoma stainedwithCytokeratin 20antibody pulmonary pulmonary or breast origin. rvln i aeoacnm ta oiiae i te I rc ta ta of that than tract GI the in originated that adenocarcinoma in prevalent more significantly was adenocarcinoma. C 20 expression lung metastatic and antibody has recently been reported to be useful to distinguish between primary differentiation oftheintestinalepithelium.C 20 development andcrypto-villus ifrnitd pteil el, n i tgty euae drn bt fetal both during regulated tightly is and cells, epithelial differentiated netnl pteim cus t h lvl f oh maue n terminally and immature both of level the at occurs epithelium intestinal the in genes keratin of regulation transcriptional that suggest strongly Results commonly found in mucosal epithelium of the mammalian gastrointestinal tract. C2) s mjr ellr rti o mtr etrcts n gbe cells goblet and enterocytes mature of protein cellular major a is (Ck20) Specificity: Cellular Localization: Cytoplasmic Positive Control: Colon Isotype: C-terminus of human C 20protein. cells, which are known to contain with cytokeratin reacts 19. antibody This 312-335. acids amino between maps epitope Specificity: Cellular Localization: Cytoplasmic Positive Control: tonsil Skin, Isotype: Monoclonal MouseAnti-Human PDM192-10MMPrediluted 10ml PDM192Prediluted 6ml Mob274-05Concentrated 0.5ml Status:Regulatory Catalog No.: Mob274Concentrated 1ml Clone: RMPD060Prediluted 6ml Status:Regulatory IVD Catalog No.: RMAB060 Concentrated 0.5ml Clone: Immunogen: Immunogen: Cytokeratin 19 Immunogen: Cytokeratin 20 Monoclonal Rabbit Anti-Human Monoclonal Rabbit ------A53-B/A2.26 P23 Rabbit IgG Rabbit IgG2a,kappa protein designated cytokeratin 20 cytokeratin designated filament (I )protein Intermediate-sized This antibody is specific to a 40 kDa protein, cytokeratin 19. Its Its 19. cytokeratin protein, kDa 40 a to specific is antibody This BALB/C mice were injected with human breast cancer MC. -7 cells. -7 MC. cancer breast human with wereinjected mice BALB/C snhtc etd crepnig o eius er the near residues to corresponding peptide synthetic A IVD F
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IVD BALB/C mice were injected with cytoskeletal fraction prepared
BALB/C mice were immunized with solubilized keratin extract from from extract keratin solubilized with immunized were mice BALB/C This antibody is specific to cytokeratin 13, 14, 15 and 16. This antibody This 16. and 15 14, 13, cytokeratin to specific is antibody This This antibody recognizes keratin polypeptides of 68, 58, 56.5 and 50 and 56.5 58, 68, of polypeptides keratin recognizes antibody This IgG1 IgG1, kappa 34 12 D -S ------Monoclonal Mouse Anti-Human Weight High Molecular Cytokeratin, Immunogen: Monoclonal Mouse Anti-Human Monoclonal Weight High Molecular Cytokeratin, Immunogen: Clone: Clone: 1ml Mob059 Concentrated No.: Catalog 6ml Prediluted PDM074 10ml Prediluted PDM074-10MM Regulatory Status: 0.5ml Mob059-05 Concentrated Mob275 Concentrated 1ml Mob275 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob275-05 Concentrated from human gingiva by detergent/salt extraction. detergent/salt by gingiva human from Isotype: Skin Control: Positive Cytoplasmic Localization: Cellular Specificity: stain not does but carcinomas adenosquamous and carcinomas squamous stains adenocarcinoma. This antibody is useful in differential staining carcinomas of from adenocarcinomas squamous and to differentiate benign and malignant glands. prostate of tumors human stratum corneum. stratum human Isotype: Skin, prostate Control: Positive Cytoplasmic Localization: Cellular Specificity: kDa in the stratum corneum. The antibody reacts with squamous, ductal other complex and epithelia. It stains adenocarcinomas, breast, pancreas, bile duct, carcinomas. cell transitional and gland salivary Formalin fixed paraffin Formalin antibodyembedded (Mob275). human tonsil stained H.M.W. with Cytokeratin Formalin fixed paraffin embeddedFormalin human tonsil stainedHMW withantibody Cytokeratin (PDM074). 55 E H P P
,/ ,/ 3 6 0 3 6 0 F F Cytokeratins isolated from human micro-dissected isolated from villi of human Cytokeratins A synthetic peptide from the C-terminus of human cytokeratin Cytokeratin 20 is less acidic than the other type I cytokeratins and is of is and cytokeratins I type other the than acidic less is 20 Cytokeratin Cytokeratin 20 is a Type-I keratin, which is expressed primarily in IgG2a, kappa IgG BV12 S 20.8 ------Immunogen: duodenal mucosa. Isotype: Skin, colon carcinoma Control: Positive Cytoplasmic Localization: Cellular Specificity: particular interest because of its restricted range of expression. This antibody reacts with cytokeratin polypeptide of 46 kDa in immunoblot analyses. Studies have shown that a marked difference exists in the expression of Cytokeratin 20 carcinomas. various among Monoclonal Mouse Anti-Human 20 Cytokeratin Immunogen: protein. 20 Isotype: carcinoma Colon Control: Positive Cytoplasmic Localization: Cellular Specificity: gastric and intestinal epithelium, urothelium, and 20 Merkel is Cytokeratin cells. expressed in adenocarcinomas of the colon, stomach, pancreas system. 20 Cytokeratin is also and present in mucinous ovarian tumors, transitional- the bile cell and Merkel cell carcinomas. Notably, the squamous adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors cell 20. carcinomas Cytokeratin and in lack carcinomas cell small and ovary, the of Clone: 0.5ml Concentrated RMAB033 No.: Catalog 6ml RMPD033 Prediluted 10ml RMPD033-10RM Prediluted Monoclonal RabbitMonoclonal Anti-Human 20 Cytokeratin IVD Regulatory Status: Clone: 1ml Mob123 Concentrated No.: Catalog 0.5ml Mob123-05 Concentrated 6ml PDM049 Prediluted 10ml PDM049-10MM Prediluted IVD Regulatory Status: Formalin fixed paraffin embedded human colon carcinoma stained with Cytokeratin 20 antibody stained with Cytokeratin carcinoma embedded human colon paraffin fixed Formalin (PDM049). Formalin fixed paraffin embedded human colon adenocarcinoma stained with Cytokeratin 20 stained with Cytokeratin adenocarcinoma colon embedded human paraffin fixed Formalin antibody (RMPD033). Page 52-56 Hard Edit.pdf 4 Page 52-56 Hard Edit.pdf 5 Primary Antibodies www.dbiosys.com (PDR035). Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin WideSpectrumantibody Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin. Pan antibody(Mob108). egulatory Status: egulatory I PDM071-10MMPrediluted 10ml PDM071Prediluted 6ml Mob108-05Concentrated 0.5ml Catalog o : Mob108Concentrated 1ml Clone: egulatory Status: egulatory I PDR035Prediluted 6ml RP010-05Concentrated 0.5ml Catalog o : RP010Concentrated 1ml human keratins. kDa Specificity: Cellular Localization: Cytoplasmic Positive Control: Skin Immunogen: Cyto eratin i e Spectrum Polyclonal Anti-Human Rabbit and squamous simple origin. of carcinomas stains It cytokeratins. of screening spectrum broad for designed been has antibody This 18. and 5,6,8 cytokeratin stains antibody Specificity: Cellular Localization: Cytoplasmic Positive Control: Skin Isotype: detergent insoluble fraction of psoriatic epidermis. Immunogen: Cyto eratin Pan Monoclonal MouseAnti-Human ------M 5D3 LP34 hsatbd s el utdfr h sann o a ra setu of spectrum broad a of staining the for suited well is antibody This . 5D3,IgG2a;LP34,IgG1 This antibody reacts with cytokeratins of 58, 56, 52, 60, 51, 48 and 68 This antibody is a cocktail of two different clones: 5D3 andLP34. This Cytokeratin isolatedfrom bovinemuzzleepidermis. MC-7 Āand line cell carcinoma breast human from Cytokeratins 360
P P 56 Formalin fixed paraffin embeddedhumaninfectedtissuestainedwithCMVantibody(Mob049R). Formalin fixed paraffin antibody(PDM006). embeddedhumanuterusstainedwithDesmin pattern with an immediate early and an early CMV antigen. Specificity: Cellular Localization: Nuclear Positive Control: lung Infected Isotype: cell lysate. Immunogen: Mob049-05RConcentrated 0.5ml Status: egulatory PDM075RPrediluted 6ml Catalog o : Mob049RConcentrated 1ml Clone: Cytomegalovirus C Coc tail Monoclonal MouseAnti-Human well as smooth muscle cells stain well with this antibody. Specificity: Cellular Localization: Cytoplasmic Positive Control : Leiomyoma Isotype: muscle. Immunogen: PDM006-10Prediluted 10ml PDM006Prediluted 6ml Mob060-05Concentrated 0.5ml Status: egulatory I Catalog o : Mob060Concentrated 1ml Clone: esmin Monoclonal MouseAnti-Human ------DDG9 CCH2 D33 DDG9, IgG2a, kappa; CCH2, DDG9,IgG2a,kappa; IgG1,kappa IgG1, kappa This antibodyreacts withdesminprotein of53kDa.Bothstriatedas This cocktail antibody stains infected cells giving a nuclear staining nuclear a giving cells infected stains antibody cocktail This BALB/C mice were immunized with purified desmin from human from desmin purified with immunized were mice BALB/C BALB/C mice were immunized with cytomegalovirus infected infected cytomegalovirus with immunized were mice BALB/C
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,/ P/ 3 6 0 F it tyrosine kinase. tyrosine it c- (Only for markets outside the U.S. For U.S. market, see index III.) index see market, U.S. For outside the U.S. markets for (Only it antigen, and lead to appropriate treatment with imatinib with treatment appropriate to lead and antigen, it I D c- it or PDGFR alpha mutation status. Reactivity for DOG1 may aid may DOG1 for Reactivity status. mutation alpha PDGFR or it c- A synthetic peptide of human DOG1 protein. DOG1 human of peptide synthetic A BALB/C mice were injected β protein. with DNA polymerase BALB/C mice were DOG1 is expressed ubiquitously in gastrointestinal stromal tumors stromal gastrointestinal in ubiquitously expressed is DOG1 This antibody is specific to 39 kDa protein known as DNA polymerase DNA as known protein kDa 39 to specific is antibody This IgG IgG2a DOG1.1 61 ------in the diagnosis of gastrointestinal stromal tumors, including PDGFRA mutants express to fail that the of inhibitor an mesylate, Monoclonal Mouse Anti-Human DO Immunogen: Isotype: tumor tissue stromal : Gastrointestinal Control Positive and membrane Cytoplasmic Localization: Cellular Specificity: of irrespective D A Polymerase, β D A Polymerase, Immunogen: Isotype: Testis Control: Positive Nuclear Localization: Cellular Specificity: carboxy- a and domain kDa 8 amino-terminal an comprises β polymerase DNA β. terminal 31 kDa domain. DNA Polymerase β, a DNA repair polymerase, is Monoclonal Mouse Anti-Human Monoclonal egulatory Status: I D egulatory Status: Clone: 1ml Mob466 Concentrated o.: Catalog 0.5ml Mob466-05 Concentrated 6ml PDM170 Prediluted 10ml PDM170-10MM Prediluted Clone: 1ml Mob319 Concentrated o.: Catalog egulatory Status: 0.5ml Mob319- 05 Concentrated constitutively constitutively expressed in cultured cells. DNA polymerase β fills single nucleotide gaps in DNA produced cells. mammalian by the base excision repair pathway of Formalin fixed paraffin embedded gastrointestinal stromal tumor stained with DOG 1 antibody paraffin fixed Formalin (Mob466). Formalin Formalin fixed paraffin embedded human prostate stained with DNA Polymerase β antibody (Mob319). 57 NEW P P
,/ ,/ 3 6 0 3 6 0 F F Desmin isolated from chicken gizzard. Desmin isolated from This antibody reacts with both smooth and striated muscle cells. This cells. muscle striated and smooth both with reacts antibody This Desmoglein-1 is a member of the desmosomal cadherin family. IgG1, kappa DBM15.53 ------Immunogen: Recombinant human desmoglein-1 protein fragment Monoclonal Mouse Anti-Human Desmoglein Clone: 1ml Mob527 Concentrated o.: Catalog 6ml PDM262 Prediluted 10ml PDM262-10MM Prediluted I D egulatory Status: Immunogen: Leiomyoma Control: Positive Cytoplasmic Localization: Cellular Specificity: antibody can be used for typing of soft tissue sarcomas. tissue soft of typing for used be can antibody Polyclonal Rabbit Anti-Human Polyclonal Desmin RP011 Concentrated 1ml RP011 Concentrated o.: Catalog 6ml Prediluted PDR026 0.5ml RP011-05 Concentrated 10ml PDR026-10RP Prediluted corresponding to intracellular domain. intracellular to corresponding Isotype: Skin Control: Positive Surface Cell Localization: Cellular Specificity: Desmosomes are intercellular adhering junctions that attachment represent sites for intermediate cell filament. Desmocollins and surface desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, . isoforms. Dsg4 and Dsg3, Dsg2, domain extracellular the desmosome, the ithin of desmoglein is essential for calcium dependent heterophilic binding to desmocollins, the whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized egulatory Status: I D egulatory Status: exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is 1 desmoglein active functionally and Intact layers. suprabasal the in exclusively essential to epidermal integrity. epidermal to essential Formalin fixed paraffin embedded human skin stained with Desmoglein paraffin 1 (Mob527). fixed Formalin Formalin fixed paraffin embedded human uterus stained with Desmin embedded human uterus stained with antibody (PDR026). paraffin fixed Formalin Page 57-61 Hard Edit.pdf 1 Page 57-61 Hard Edit.pdf 2 Primary Antibodies www.dbiosys.com (Mob387). antibody (Mob381). Formalin fixed paraffin embeddedhumanuterusstainedwithE2F-1Transcription Factor antibody Dystrophin with stained muscle skeletal human embedded Formalin paraffin fixed progression progression and oncogenesis. E2F-1 over expression can also drive cells into apoptosis. involved in several cellular processes that range from tumor suppression, cell cell suppression, tumor from range that processes cellular several in involved protein, resulting in an altered rate of gene transcription. E2F-1 is proposed to be be to proposed is E2F-1 transcription. gene of rate altered an in resulting protein, proteins, which associate with negative regulators, such as the retinoblastoma p107 p107 retinoblastoma the as such regulators, negative with associate which proteins, actin-binding actin-binding protein. of family actinin spectrin/α of member a is Dystrophin spectrin. muscle human and α-actin C-protein, with cross-reaction no shows and dystrophin to specific Specificity: Cellular Localization: Cell membrane Positive Control: Skeletalmuscle Isotype: electric organ. enriched membranes and peripheral membrane proteins from Torpedo nobiliana o310 ocnrtd05l Mob381-05Concentrated 0.5ml Status: egulatory Catalog o.: Mob381Concentrated 1ml Clone: Mob387-05Concentrated 0.5ml Status: egulatory Catalog o.: Mob387Concentrated 1ml Clone: 2- rncito atr E2F- ranscription Factor Monoclonal MouseAnti-Human Immunogen: Dystrophin Monoclonal MouseAnti-Human Specificity: Cellular Localization: Nuclear Positive Control : Tonsil, breast carcinoma Isotype: protein. Immunogen: ------ H95 1808 IgG1 IgG2a This antibody reacts with a protein of 60 kDa. E2Fs are DNA-binding DNA-binding are E2Fs kDa. 60 of protein a with reacts antibody This This antibody reacts with a protein of 427 kDa. This antibody is highly ABC ie ee muie wt aeycoie receptor acetylcholine with immunized were mice BALB/C BALB/C mice were immunized with a recombinant human E2F-1 human recombinant a with immunized were mice BALB/C F I D I D (Only for markets outsidetheU.S. For U.S. market, seeindex III.)
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I D Bovine α-elastin. Recombinant human TACSTD1 protein. TACSTD1 Recombinant human Ep-CAM is over expressed by the majority of human epithelial This antibody recognizes insoluble elastin, α-elastin, soluble non- Rabbit IgG IgG1 BA-4 DBR16.15 ------Clone: 1ml Mob230 Concentrated o.: Catalog egulatory Status: 0.5ml Mob230-05 Concentrated Monoclonal Rabbit Anti-Human Ep-CAM/CD326 Clone: 0.5ml Concentrated RMAB100 o.: Catalog 10ml RMPD100-10RM Prediluted I D egulatory Status: 1ml Concentrated RMAB100-1 6ml RMPD100 Prediluted Immunogen: Isotype: carcinoma Colon Control: Positive Surface Cell Localization: Cellular Specificity: in useful is EP-CAM to antibody An carcinoma. hepatocellular except carcinomas identification of epithelial tumors and to differentiate metastasis. liver primary from hepatocellular carcinoma Monoclonal Mouse Anti-Human Monoclonal Elastin Immunogen: Isotype: Heart, kidney Control: Positive tissue Connective Localization: Cellular Specificity: of elastin (tropoelastin). Elastin is an important linked precursor cross polymeric tissues. elastic vertebrate to elasticity imparts that tissue connective of protein Formalin fixed paraffin embeddedFormalin human colon stainedadenocarcinoma with Ep-CAM (RMAB100). Formalin Formalin fixed paraffin embedded human renal cell carcinoma stained with Elastin antibody (Mob230). 59 NEW P P
,/ ,/ 3 6 0 F F Recombinant human E-Cadherin protein. E-Cadherin human Recombinant A synthetic peptide corresponding to residues in the 5th cadherin 5th the in residues to corresponding peptide synthetic A E-Cadherin is a transmembrane glycoprotein, plays an important role role important an plays glycoprotein, transmembrane a is E-Cadherin E-cadherin plays an important role in epithelial cell adhesion. A decreasedA adhesion. cell epithelial in importantrole an E-cadherinplays Breast carcinoma, colon carcinoma colon carcinoma, Breast Control: IgG1, kappa IgG1, Rabbit IgG Cell Surface Cell Localization: DBM15.49 EP6 ------ egulatory Status: I D egulatory Status: Monoclonal Mouse Anti-Human E-Cadherin/CD324 Clone: 1ml Mob523 Concentrated o.: Catalog 10ml PDM258-10MM Prediluted 6ml PDM258 Prediluted Immunogen: Isotype: Positive Cellular Specificity: Immunogen: protein. E-Cadherin human of domain Isotype: colon carcinoma Colon, Control: Positive Membrane Localization: Cellular Specificity: in epithelial cell adhesion. A decreased expression of E-Cadherin is associated with metastatic potential and poor prognosis in breast cancer and esophagus cancer. In combination with antibody against p120 Catenin or Cytokeratin, E- Cadherin antibody is useful for the differentiation between ductal (E-Cadherin in help also may It carcinomas. breast negative) (E-Cadherin lobular and positive) Monoclonal RabbitMonoclonal Anti-Human E-Cadherin Clone: 0.5ml Concentrated RMAB041 o.: Catalog 6ml Prediluted RMPD041 I D egulatory Status: 1ml Concentrated RMAB041-1 expression of E-cadherin is associated with metastatic potential and poor prognosis inprognosis poor andpotential metastatic withE-cadherin associatedofis expression diagnosis of mesothelioma. of diagnosis breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it isitCatenin,p120with In combination cancer. esophagealandprostate cancer, breast useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma. of diagnosis inhelp also mayIt carcinomas. breast Formalin fixed paraffin embedded human breast carcinoma stained with E-Cadherin (Mob523). embedded human breast carcinoma paraffin fixed Formalin Formalin fixed paraffin embedded human breast carcinoma stained with E-Cadherin antibody embedded human breast carcinoma paraffin fixed Formalin (RMAB041). Page 57-61 Hard Edit.pdf 3 Page 57-61 Hard Edit.pdf 4 Primary Antibodies www.dbiosys.com (Mob520). Formalin fixed paraffin embeddedhumancolon adenocarcinoma stainedwithEp-CAM/CD326 (Mob505). Formalin fixed paraffin embeddedhumancolon adenocarcinoma stainedwithEp-CAM/CD326 carcinoma hepatocellular from primary liver metastasis. differentiate to and tumors epithelial of identification carcinomas except hepatocellular carcinoma. An antibody to EP-CAM is useful in Specificity: Cellular Positive Isotype: carcinoma hepatocellular from primary liver metastasis. differentiate to and tumors epithelial of identification carcinomas except hepatocellular carcinoma. An antibody to EP-CAM is useful in Specificity: Cellular Positive Isotype: extracellular domain (aa77-202). PDM233Prediluted 6ml Status:Regulatory IVD PDM233-10MMPrediluted 10ml Catalog No.: Mob505Concentrated 1ml Clone: PDM255Prediluted 6ml Status:Regulatory IVD PDM255-10MMPrediluted 10ml Catalog No.: Mob520Concentrated 1ml Clone: eobnn hmn pA poen rget rm the from fragment protein EpCAM human Recombinant Immunogen: Ep-CA /CD 2 Monoclonal MouseAnti-Human Immunogen: Ep-CA /CD 2 Monoclonal MouseAnti-Human ------DBM15.31 DBM15.46 Localization: Cell surface Localization: Cell surface IgG IgG Control: Colon adenocarcinoma Control: Breast carcinoma, colon adenocarcinoma pCM s vr xrse b te aoiy f ua epithelial human of majority the by expressed over is Ep-CAM pCM s vr xrse b te aoiy f ua epithelial human of majority the by expressed over is Ep-CAM A recombinant human EpCAM fragment from the extracellular domain. F F 3 60 3 60 ,/ ,/
P P H H NEW NEW 60 Formalin fixed paraffin embedded human placenta stained with EGFR antibody (Mob267). antibody EGFR with stained placenta human embedded Formalin paraffin fixed Mob267-05Concentrated 0.5ml Status:Regulatory PDM132Prediluted 6ml Catalog No.: Mob267Concentrated 1ml Clone: in squamous cell carcinoma. expressed andendometrium.EGFRisover vulva,ovary esophagus, cervix, neck, and head stomach, bladder,lung, brain, breast, of tumors in reported been has an epitope mapping in the extracellular domain of EGFR. Overexpression of EGFR member of the type I family of growth factor receptors. The antibody recognizes Specificity: Cellular Localization: Cell membrane Positive Control: Placenta Isotype: recombinant EGFR protein. Immunogen: Epidermal Growth Factor Receptor (EGFR) Monoclonal MouseAnti-Human Primary Antibodies Primary Diagnostic BioSystems IHC Solutions -Innovative,IHC Solutions H isit usat:www.dbiosys.com/primary-antibodies 111.6 IgG1 Ti atbd i seii t a 7 ka rti. G-eetr s a is EGF-Receptor protein. kDa 170 a to specific is antibody This
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,/ 3 6 0 (Only for markets outside the U.S. For U.S. market, see index III.) index see market, U.S. For outside the U.S. markets for (Only F IVD BALB/C mice were immunized with human breast carcinoma cell Human EGFR derived from A-431 cell line. from Human EGFR derived The epidermal growth factor receptor (EGFR) is a 170 kDa Epithelial antigen is a cell surface glycoprotein and is broadly IgG1, kappa IgG1 Ber-EP4 31G7 ------Monoclonal Mouse Anti-Human Epithelial Antigen Clone: 1ml Mob406 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob406-05 Concentrated 6ml PDM131 Prediluted 10ml PDM131-10MM Prediluted Immunogen: line,MCF-7. Isotype: carcinoma breast idney, Control: Positive membrane Cell Localization: Cellular Specificity: distributed in epithelial cells and displays carcinomas. Epithelial a antigen has highly been shown conserved to play expression an important in role as a tumor cell marker in lymph nodes from patients with esophageal Epithelial carcinoma. antigen can be used to distinguish between basal cell and Epidermal Growth Factor Receptor (EGFR) Receptor Factor Growth Epidermal Immunogen: Isotype: placenta carcinoma, Breast Control: Positive cytoplasm Membrane, Localization: Cellular Specificity: Clone: 1ml Mob461 Concentrated No.: Catalog Regulatory Status: 0.5ml Mob461-05 Concentrated Monoclonal Mouse Anti-Human Monoclonal basosquamous carcinomas and squamous cell carcinoma of the skin. the of carcinoma cell squamous and carcinomas basosquamous transmembrane transmembrane protein consisting of an extracellular EGF-binding domain, a short transmembrane region and an intracellular domain with ligand-activated tyrosine kinase activity. EGFR is expressed in many particularly normal in epithelial the tissues, basal layers of stratified epithelium and in squamous epithelium. transcription. Over protein increased expression and/or amplification gene of of result EGFR a as neoplasia, has been observed in many types of Formalin Formalin fixed paraffin embedded human breast carcinoma stained with Epithelial Antigen (PDM131). Formalin fixed paraffin embedded human placenta stained with EGFR antibody (Mob461). embedded human placenta paraffin fixed Formalin 61 P P , , F F (Only for markets outside the U.S. For U.S. market, see index III.) see index market, U.S. For outside the U.S. markets for (Only (Only for markets outside the U.S. For U.S. market, see index III.) see index market, U.S. For outside the U.S. markets for (Only IVD IVD A synthetic peptide from C-terminus of human EGFR protein. A synthetic peptide from A synthetic phosh- peptide corresponding to residues Tyr1068 of This antibody recognizes EGFR. EGFR is a type I receptor tyrosine receptor I type a is EGFR EGFR. recognizes antibody This IgG Rabbit IgG EP22 SP9 ------Monoclonal RabbitMonoclonal Anti-Human Immunogen: Monoclonal Rabbit Anti-Human (EGFR) Receptor Factor Epidermal Growth Immunogen: Isotype: Placenta, lung Control: Positive cell membrane Cytoplasmic, Localization: Cellular Specificity: kinase with sequence homology to erbB-1, -2, -3, -4. It binds to epidermal growth growth epidermal to binds It -4. -3, -2, erbB-1, to homology sequence with kinase factor (EGF), transforming growth factor-α of (TGF-α),tumors in overexpressed heparin-binding is EGFR epiregulin. EGF and β-cellulin amphiregulin, EGF), (HB- ovary, vulva, cervix, esophagus, neck, head, stomach, lung, bladder, brain, breast, carcinomas. cell squamous in present predominantly is It endometrium. and Epidermal Growth Factor Receptor (EGFR) Receptor Factor Growth Epidermal Clone: 0.5ml Concentrated RMAB064 No.: Catalog Regulatory Status: 6ml RMPD064 Prediluted Clone: 0.5ml Concentrated RMAB020 No.: Catalog Regulatory Status: 6ml RMPD020 Prediluted human EGFR was used as immunogen. The antibody detects both EGFR phosphorylated on Tyr1068 of the mature human isoform 1 (corresponding to . 1092 from the precursor form P00533-1/p170), and also unphosphorylated EGFR. unphosphorylated also and P00533-1/p170), .form precursor the from 1092 Isotype: Placenta Control: Positive Membrane Localization: Cellular Specificity: Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation. Binding of Binding differentiation. and growth cell affects (EGF), factor growth epidermal EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor. Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational conformational for required is 1086 Tyr and 1068 Tyr 992, Tyr Phosphorylationof change in the C-terminal of EGFR. Autophosphorylation of binding Tyr 992 site creates for a the phospholipase C-gamma (PLC-gamma) SH2 domain, inducing inducing downstream signaling. In breast cancer, EGFR is predominately expressed expressed in basal cell-like carcinoma, it has been recommended for identification of basal-like breast carcinoma along with Cytokeratin 5/6. Cytokeratin with along carcinoma breast basal-like of identification Formalin fixed paraffin embedded human placenta stained with EGFR antibody (RMAB064). embedded human placenta paraffin fixed Formalin Formalin fixed paraffin embedded human placenta stained with EGFR antibody (RMAB020). embedded human placenta paraffin fixed Formalin Page 57-61 Hard Edit.pdf 5 Page 62-66 Hard Edit.pdf 1 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhuman breast carcinoma stainedwithEMAantibody(PDM007). (Mob062). Antigen Epithelial with stained carcinoma breast human embedded paraffin fixed Formalin Regulatory Status:Regulatory IVD shows a patchy staining normal with squamous epithelium. Among cells. neoplastic and epithelia, it reacts normal strongly with both mammary epithelium and stains glandular epithelia but It proteins. fat globule milk human called proteins glycosylated heavily of group heterogeneous Specificity: Cellular Localization: Cell membraneandcytoplasmic Positive Control: Breast carcinoma Isotype: membranes. Regulatory Status:Regulatory IVD PDM007-10MMPrediluted 10ml PDM007Prediluted 6ml Mob063-05Concentrated 0.5ml Catalog No.: Mob063Concentrated 1ml Clone: PDM077-10MMPrediluted 10ml PDM077Prediluted 6ml Mob062-05Concentrated 0.5ml Catalog No.: Mob062Concentrated 1ml Clone: ABC ie ee muie wt hmn ik a globule fat milk human with immunized were mice BALB/C Immunogen: Epithelial Membrane Antigen (EMA) Monoclonal MouseAnti-Human nonkeratinized squamous epithelium. on theepithelialcells. stainswithsimpleepitheliaand basallayers It ofstratified Specificity: Cellular Localization: Cell membrane Positive Control: Breast carcinoma Isotype: Immunogen: Epithelial Antigen Monoclonal MouseAnti-Human ------GP1.4 V -1D9 IgG1,kappa IgG1,kappa This antibody reacts with an antigen of 265-400 kDa belonging to a This antibody reacts with two glycoproteins of 34 and 49 kDa present BALB/Cmicewere immunizedwithsmallcelllungcarcinoma. F 360 360 F ,/
P E , P 62 (Mob401). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithEpithelialAntigen Formalin fixed paraffin embeddedhumaninfectedtissuestainedwithEBV(Mob194). Monoclonal MouseAnti-Human Monoclonal MouseAnti-Human Status:Regulatory IVD PDM204-10MMPrediluted 10ml PDM204Prediluted 6ml Mob401-05Concentrated 0.5ml Catalog No.: Mob401Concentrated 1ml Clone: PDM128Prediluted 6ml Mob194-05Concentrated 0.5ml Status:Regulatory Catalog No.: Mob194Concentrated 1ml Clone: but showsapatchy stainingwithsquamousepithelium. epitheliumandglandularepithelia stronglyepithelia, itreacts withmammary globule proteins. stainsbothnormalandneoplasticcells. Amongnormal It heterogeneous group ofheavily glycosylated proteins calledhumanmilkfat Specificity: Cellular Localization: Cell membraneandcytoplasmic Positive Control: Breast carcinoma Isotype: globule membranepreparation. Immunogen: Epithelial Membrane Antigen (EMA) immunoblasts in infectious mononucleosis. stains strongly with EBV positive lymphoblastoid cell lines and EBV infected B cell on the hydrophilic C-terminus of the cytoplasmic domain of LMP-1. This antibody encoded by the BNLF1 gene of the EBV. Each clone reacts with different epitopes Specificity: Cellular Localization: Cytoplasmic Positive Control: lymphoblastoma Infected Isotype: β-galactosidase and EBV encoded latent membrane protein. Immunogen: Epstein-Barr Virus (EBV) ------E29 CS1, CS2,CS3,CS4 IgG2a,kappa IgG1 This antibodyreacts withanantigenof265-400kDabelongingtoa This antibody is specific to 60 kDa latent membrane protein (LMP-1) BALB/Cmicewere immunizedwithdelipidatedhumanmilkfat Recombinant fusion protein containing sequences of bacterial IVD (Only for markets outsidetheU.S. For U.S. market, seeindex III.) F 360 ,
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IVD IVD A synthetic peptide derived from C-terminus of human estrogen Prokaryotic recombinant protein corresponding to the full-length the to corresponding protein recombinant Prokaryotic PDM048 Prediluted 5ml PDM048 Prediluted This antibody is specific to estrogen receptor, which is associated IgG1 6F11 ------Polyclonal Rabbit Anti-Human Polyclonal Receptor Estrogen Immunogen: receptor. carcinoma Breast Control: Positive Nuclear Localization: Cellular Specificity: Recognizes a protein named estrogen receptor (ER) α. The ER gene Monoclonal Mouse Anti-Human Monoclonal Receptor Estrogen Clone: 0.5ml Mob121 Concentrated No.: Catalog Immunogen: molecule. receptor estrogen Isotype: carcinoma Breast Control: Positive Nuclear Localization: Cellular Specificity: with superior prognosis and a better response to nuclei anti-estrogen therapy. of The the cytoplasm. the estrogen in staining any receptor without antibody, positive cells stain very strongly with this RP141 Concentrated 1ml RP141 Concentrated No.: Catalog Regulatory Status: 0.5ml RP141-05 Concentrated Regulatory Status: Regulatory Status: consists of more than 140kb of genomic DNA divided into 8 exons, being translated translated being exons, 8 into divided DNA genomic of 140kb than more of consists into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER The carcinomas. breast in cells epithelial of nucleus the stains strongly antibody is an important regulator of growth and differentiation in the mammary gland. mammary the in differentiation and growth of regulator important an is Formalin fixed paraffin embedded human breast carcinoma stained with Estrogen Receptor stained with Estrogen embedded human breast carcinoma paraffin fixed Formalin antibody (RP141). Formalin fixed paraffin embedded human breast carcinoma stained with Estrogen Receptor embedded human breast carcinoma paraffin fixed Formalin antibody (Mob121). 63 H P
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IVD A synthetic peptide corresponding to residues on the C-terminus on the C-terminus to residues A synthetic peptide corresponding BALB/C mice were injected with full length recombinant human ERG, the ETS related gene, belongs to the ETS family that plays belongs to the ETS family that plays ERG, the ETS gene, related This antibody reacts with a 33-36 kDa protein known as ERCC1 F IgG IgG2b 8F1 EP111 ------Immunogen: of the human ERG protein. Isotype: carcinoma Prostate Control: Positive Nuclear Localization: Cellular Specificity: apoptosis proliferation, differentiation, important in cell development, roles The ERG antibody identifies endothelial cells, and tissue remodeling. lymphocytes cancer cells. and prostate Monoclonal Rabbit Anti-Human ERG Immunogen: protein. ERCC1 Isotype: Tonsil Control: Positive Nuclear Localization: Cellular Specificity: (excision (excision repair cross complementing) nucleotide excision polypeptide. repair of damaged ERCC1 DNA and is is homologous to RAD10. mammalian required cells, In XPG cleaves for 3’ of the DNA lesion incision. while ERCC1-XPF 5’ complex the makes Clone: 1ml Mob336 Concentrated No.: Catalog 0.5ml Mob336-05 Concentrated 6ml PDM151 Prediluted 10ml PDM151-10MM Prediluted Monoclonal Mouse Anti-Human Mouse Anti-Human Monoclonal ERCC1 Regulatory Status: Clone: 6ml RMPD034 Prediluted No.: Catalog 10ml RMPD034-10RM Prediluted Regulatory Status: IVD Regulatory Status: Formalin fixed paraffin embedded human prostate carcinoma stained with ERG antibody embedded human prostate carcinoma paraffin fixed Formalin (RMPD034). Formalin fixed paraffin embedded human tonsil stained with ERCC1 antibody (Mob336). ERCC1 embedded human tonsil stained with paraffin fixed Formalin Page 62-66 Hard Edit.pdf 2 Page 62-66 Hard Edit.pdf 3 Primary Antibodies www.dbiosys.com antibody (RMAB051). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithEstrogenReceptor Alpha antibody (RMPD001). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithEstrogenReceptor RMPD001Prediluted 6ml Status:Regulatory Catalog No.: RMAB001 Concentrated 0.5ml Clone: RMPD051Prediluted 6ml Status:Regulatory Catalog No.: RMAB051 Concentrated 0.5ml Clone: f eti gns Lgn-eedn dmrzto ad hshrlto both phosphorylation function to and regulate dimerizationthe transcriptional Ligand-dependent activation genes. of ER alpha. certain of ligand binding domains, and exerts a significant role in activating the transcription of the steroid hormone receptor family. ER alpha possesses both DNA binding and Specificity: Cellular Localization: Nuclear Positive Control: Breast carcinoma Isotype: Immunogen: Estrogen Receptor Alpha Anti-Human Monoclonal Rabbit anti-estrogen (e.g. tamoxifen) therapy. responseto of increasedlikelihood indicates an Presence breasttumors in ER of ER is an important regulator of growth and differentiation in the mammary gland. important an carcinomas.breast in cells epithelial of The nucleus the stains stronglyantibody is tissue cancer breast of parameter in the prediction content of prognosis and response ER to endocrine therapy. (ER). This receptor estrogen Specificity: Cellular Localization: Nuclear Positive Control: Breast carcinoma Isotype: receptor. Immunogen: Estrogen Receptor Anti-Human Monoclonal Rabbit ------SP1 EP1 Rabbit IgG Rabbit IgG Estrogen Receptor Alpha (ER Alpha) is a nuclear protein and member This antibody recognizes a protein of 67kDa, which is identified as identified is which 67kDa, of protein a recognizes antibody This AsynthetichumanERalphaprotein. estrogen human of C-terminal from derived peptide Synthetic IVD IVD (Only for markets outsidetheU.S. For U.S. market, seeindex III.) (Only for markets outsidetheU.S. For U.S. market, seeindex III.) F F ,/ ,
P P H 64 Formalin fixed paraffin embeddedrenalcell carcinoma stainedwithEzrinantibody(Mob380). (Mob196). Formalin fixed paraffin embeddedhumantonsilstainedwithFactor VIIIRelatedAntigenantibody adenocarcinomas. zi i as epesd y eti eihla tmr, uh s ea cell renal as such tumors, epithelial certain by expressed also is Ezrin binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. in not but cells epithelial expressed in is capacity.binding Ezrin cytoplasmic cytoplasmic protein, enriched in microvilli and other cell surfaces. Ezrin has an actin- iae usrt ad s hshrltd n G-tmltd el. zi i a is Ezrin cells. EGF-stimulated in phosphorylated is and substrate kinase D091M rdltd1m PDM019-10MMPrediluted 10ml PDM019Prediluted 6ml Mob196-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob196Concentrated 1ml Clone: Specificity: Cellular Localization: Cell membrane Positive Control: Lung Isotype: human ezrin corresponding to amino acid 362-585. Immunogen: Mob380-05Concentrated 0.5ml Status:Regulatory Catalog No.: Mob380Concentrated 1ml Clone: Ezrin/p81/Cytovillin also reacts with megakaryocytes in human bone marrow. Specificity: Cellular Localization: Cytoplasmic Positive Control: Tonsil Isotype: Immunogen: Willebrand Factor Factor VIII Related Antigen/Von Monoclonal MouseAnti-Human Monoclonal MouseAnti-Human ------F8/86 3C12 IgG1 IgG1,kappa This antibody reacts with a protein of 81 kDa. Ezrin serves as a tyrosine tyrosine a as serves Ezrin kDa. 81 of protein a with reacts antibody This This antibody reacts with Von Willebrand factor in endothelial cells. It BALB/C mice were immunized with a recombinant fragment of fragment recombinant a with immunized were mice BALB/C Von Willebrand isolatedfrom factor humanplasma. IVD F
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Hodgkins Ālymphoma, ovary Ālymphoma, Hodgkins Recombinant protein corresponding to A-subunit of coagulation Full length recombinant human FSCN1 protein. FSCN1 human recombinant length Full This antibody reacts with a 160 kDa (unreacted dimer) and 80 kDa F Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells Control: IgG2a, kappa IgG2a, Localization:
DBM15.6 ------Specificity: and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Monoclonal Mouse Anti-Human Fascin-1 Clone: 1ml Mob496 Concentrated No.: Catalog IVD Regulatory Status: 6ml PDM216 Prediluted 10ml PDM216-10MM Prediluted Immunogen: Isotype: Positive Cellular Polyclonal Rabbit Anti-Human Polyclonal XIII-A Factor 1ml RP103 Concentrated No.: Catalog 6ml Prediluted PDR054 IVD Regulatory Status: 0.5ml Concentrated RP103-05 Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid myeloid and cells, plasma cells, lymphoid in negative uniformly is It disease. s Hodgkin cells. Fascin-1 is also expressed in dendritic cells. distinguish This between Hodgkin marker lymphoma may and be non-Hodgkin lymphoma helpful in to difficult cases. Also, the lack of expression of fascin-1 follicular in reactive from the lymphomas these neoplastic distinguishing in follicles helpful in be may follicular lymphoma hyperplasia in which the number of follicular dendritic cells is normal or increased. induced be Antibody may to fascin-1 has been suggested as expression a marker prognostic in neuroendocrine Fascin-1 cancer. ovarian in as well as lung the of neoplasms of induction viral that possibility the with cells B of infection (EBV) virus Epstein-Barr cases. by EBV-positive in considered be also must types cell other or lymphoid in fascin Immunogen: a. XIII Factor Placenta Control: Positive nuclear Cytoplasmic, Localization: Cellular Specificity: (reduced monomer) protein. Factor XIII is a β-globulin found in plasma and is composed of dendrocyte dermal a two is XIII subunits, Factor Factor kDa. 160 XIII-A M.W. and of dimer Factor a is XIII-B. and subunit Factor catalytic XIII-A is the be can XIII Factor tumors. of types these with reaction variable shows and marker used for histiocytic system. nervous central phenotyping the of tumors and and hemangiomas has been reported to mark capillary Formalin fixed paraffin embedded human Hodgkin's lymphoma stained with Fascin-1 (Mob496). lymphoma stained with Fascin-1 embedded human Hodgkin's paraffin fixed Formalin Formalin fixed paraffin embedded human placenta stained with Factor XIII-A antibody (RP103). stained with Factor embedded human placenta paraffin fixed Formalin 65 E H P P
,/ ,/ 3 6 0 3 6 0 F F BALB/C mice were injected with recombinant human protein Factor VIII related antigen isolated from human plasma. antigen isolated from VIII related Factor This antibody is specific to 160 kDa protein known as Factor XIII-A. This antibody reacts antigen. ItVIII related with human factor stains IgG1, kappa AC-1A1 ------Immunogen: XIII. Factor coagulation of A-subunit to corresponding Isotype: Placenta Control: Positive nuclear Cytoplasmic, Localization: Cellular Specificity: FactorXIII is a β-globulin found in plasma and is composed of two subunits, Factor Factor subunits, two of composed is and plasma in found β-globulin a is FactorXIII Factor XIII-A Factor Monoclonal Mouse Anti-Human Immunogen: Tonsil Control: Positive Cytoplasmic Localization: Cellular Specificity: endothelial cells and megakaryocytes in various human tissues. This antibody not antibody This tissues. human various in megakaryocytes and cells endothelial types. cell other any with cross-react Regulatory Status: IVD Regulatory Status: Clone: 1ml Mob321 Concentrated No.: Catalog 6ml PDM141 Prediluted 10ml PDM141-10MM Prediluted 0.5ml Mob321 Concentrated XIII-A and Factor XIII-B. Factor XIII-A is the catalytic subunit and is a dimer of M.W. M.W. of dimer a is and subunit catalytic the is XIII-A Factor XIII-B. Factor and XIII-A 160 kDa. Factor XIII is a dermal dendrocyte marker and v variable reaction with tumors. of types these Polyclonal Rabbit Anti-Human Polyclonal Factor VIII Related Antigen/Von Antigen/Von VIII Related Factor Factor Willebrand RP012 Concentrated 1ml RP012 Concentrated No.: Catalog 6ml Prediluted PDR014 10ml Prediluted PDR014-10RP IVD Regulatory Status: 0.5ml RP012-05 Concentrated Formalin fixed paraffin embedded human placenta stained with Factor XIII-A antibody (Mob321). stained with Factor embedded human placenta paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with Factor VIII Related Antigen antibody Factor embedded human tonsil stained with paraffin fixed Formalin (RP012). Page 62-66 Hard Edit.pdf 4 Page 62-66 Hard Edit.pdf 5 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithFibroblast (Mob197-1). Formalin fixed paraffin embeddedhumankidneystainedwithFerritin LightChain(Mob516). Mob197-1-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob197-1Concentrated 1ml Clone: PDM251Prediluted 6ml Status: egulatory I PDM251-10MMPrediluted 10ml Catalog o.: Mob516Concentrated 1ml Clone: but does stain malignant fibrosarcoma tissue. cells,epithelial human or lymphocytes stain monocytes. not does antibody This blood peripheral of and 95% and foreskin macrophages tissue (synovial, lines, cell fibroblasts fibroblast thymic), on protein surface a with reacts It weight. Specificity: Cellular Localization: Membrane Positive Control: Thymus Isotype: Immunogen: Fi ro last Monoclonal MouseAnti-Human factor important in an the developmentstress, of oxidative ageing-related and cataracts. overexpressed, is ferritin chain light which syndrome,in cataract hyperferritinemia hereditary mechanisms, two least of at by nucleation the promote chains light ferrihydrite, enabling storage ferritin of Fe (III). Light chain whereas ferritin is involved in cataracts (II), Fe of oxidation Specificity: Cellular Positive Isotype: Immunogen: Ferritin Light Chain Monoclonal MouseAnti-Human ------1B10 DBM15.42 Localization: Cytoplasmic IgM IgG2a Control: Pancreas, Kidney This antibody reacts with proteins of 43 kDa and 72-80 kDa molecular the storage, iron in step first the catalyze chains heavy Ferritin Cultured humanthymic fibroblasts. Recombinant human FTL protein fragment (aa 38-165). F F 3 60 , ,
P P NEW 66 Formalin fixed paraffin embeddedhumankidneystainedwithFibronectin antibody(RP013). Formalin fixed paraffin embeddedhumanskinstainedwithFlk-1 antibody(RP076). factor factor and is putatively involved in the growth of endothelial cells and angiogenesis. eetr iae Fk1 s hg afnt rcpo fr aclr nohla growth endothelial vascular for receptor affinity high a is Flk-1 kinase. receptor immunoelectrophoresis. vascular endothelial growth factor receptor 2 (VEGFR2). Flk-1 is a cell membrane membrane cell a is Flk-1 (VEGFR2). 2 receptor factor growth endothelial vascular RP013-05Concentrated 0.5ml Status: egulatory I Catalog o.: RP013Concentrated 1ml adsorption. Only the fibronectin arch was observed in crossed in observed was arch fibronectin the Only adsorption. solid-phase by removed been have antibodies contaminating kidney.Tracesof Specificity: Cellular Localization: Basementmembrane, connective tissue Positive Control: Kidney Immunogen: Fi ronectin Polyclonal Anti-Human Rabbit Specificity: Cellular Localization: Cytoplasmic Positive Control: Angiosarcoma form of the mouse Flk-1. Immunogen: RP076-05Concentrated 0.5ml Status: egulatory I Catalog o.: RP076Concentrated 1ml Flk-1 F Polyclonal Anti-Human Rabbit ------This antibody reacts with a 180 kDa protein, known as Flk-1, KDR or or KDR Flk-1, as known protein, kDa 180 a with reacts antibody This This antibodyreacts inliver, withhumanfibronectin and tonsil, skin Fibronectin isolatedfrom apoolofnormalhumanplasma. A synthetic peptide derived from the C-terminus of the precursorthe of C-terminus fromthe derived peptide synthetic A F F , ,
P P 2/17/17 5:03PM Primary Antibodies 2/17/17 5:04 PM NEW www.dbiosys.com H P H P
, , 3 6 oncentrated 1ml F F BALBC Āmice were immunized with prokaryotic recombinant Recombinant human FSHR protein. FSHR human Recombinant Mob4 5- 5 Concentrated .5ml Mob4 5- 5 Concentrated Linkage studies suggest that a missense mutation in the FSHR gene FSHR the in mutation missense a that Linkagesuggest studies tosidase binding lectin family. Galectin-3 is a member of the -galactosidase binding lectin family. IgG1
IgG1
9C4 DBM15.59 ------Galectin-3 Clone: Mob4 5 C o.: Catalog I Regulatory Status: Immunogen: Monoclonal Mouse Anti-Human Monoclonal FSH-Receptor Immunogen: Isotype: Monoclonal Mouse Anti-Human Clone: 1ml Mob533 Concentrated o.: Catalog I Regulatory Status: 6ml PDM26 Prediluted Ā 1ml PDM26 -1 MMPrediluted Ovary Control: Positive Cytoplasmic Localization: Cellular Specificity: can cause reduced FSH binding affinity ovarian hypergonadotropic dysgenesis this (ODG). Inmutation males, however, and lead to a condition does not known appear to as have a detrimental affect on fertility. mutation It in is believed the that FSHR a gene is also condition Āa syndrome characterized associated by with the ovarian presence hyperstimulation of cells. luteinized multiple by serous lined cysts and follicular hemorrhagic fusion protein corresponding to the full-length galectin-3 molecule. galectin-3 full-length the to corresponding protein fusion Isotype: Prostate Control: Positive Cytoplasmic Localization: Cellular Specificity: Cell surface galectin3 Āmay be involved in homotypical cell downregulated in colon and Downregulation breast of cancer. galectin-3 adhesion could and is be one of the many events that enable cancer cells to interact with laminin to facilitate invasion and metastasis. Galectin-3 has been detected lymphomas. cell in large anaplastic Formalin fixed paraffin embedded human prostate stained with Galectin-3 antibody (Mob405). paraffin fixed Formalin Formalin fixed paraffin embedded human ovary stained with FSH-Receptor (PDM268). stained with FSH-Receptor embedded human ovary paraffin fixed Formalin 6 H H P P
, , oncentrated 1ml F A synthetic peptide derived from C-terminus of human Flt-4. from A synthetic peptide derived A synthetic peptide derived from the C-terminus of the Flt-1 RP - 5 Concentrated .5ml RP - 5 Concentrated Three cell membrane receptor tyrosine kinases, Flt (also designated (also Flt kinases, tyrosine receptor membrane cell Three kDa protein, known as Flt-1 or vascular or Flt-1 as known protein, kDa a 1 with reacts antibody This F ------Immunogen: Placenta Control: Positive cell membrane Cytoplasmic, Localization: Cellular Specificity: VEGFR1), Flk-1 (also designated VEGFR2) and Flt-4 (also putatively designated involved in the VEGFR3), growth of endothelial cells, are characterized by the domain. extracellular their in sequences immunoglobulin-like seven of presence Flt- that speculated been has it Flk-1, and Flt to similarity structural of basis the On ligand. VEGF-related a or VEGF other for receptor third a represent might 4 Flt- Polyclonal Rabbit Anti-Human Polyclonal Immunogen: origin. human of precursor Bladder tumor Control: Positive Cytoplasmic Localization: Cellular Specificity: membrane receptor 1 (VEGFR1). is a cell receptor Flt-1 factor endothelial growth and factor growth endothelial vascular for receptor affinity high a has Flk-1 kinase. Polylonal Rabbit Anti-Human Polylonal Flt- GFR RP C o.: Catalog I Regulatory Status: RP135 Concentrated 1ml RP135 Concentrated o.: Catalog .5ml RP135- 5 Concentrated I Regulatory Status: is putatively involved in the growth of endothelial cells and angiogenesis. and cells endothelial of growth the in involved putatively is Formalin fixed paraffin embedded human bladder carcinoma stained with Flt-4 antibody (RP135). stained with Flt-4 embedded human bladder carcinoma paraffin fixed Formalin Formalin fixed paraffin embedded human bladder carcinoma stained with Flt-1 antibody (RP077). stained with Flt-1 bladder carcinoma embedded human paraffin fixed Formalin Page 67-71 Hard Edit.pdf 1 Page 67-71 Hard Edit.pdf 2 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanbrain stainedwithGFAP antibody(RP014). Formalin fixed paraffin embeddedstomachstainedwithGastrinantibody(RP044). Regulatory Status:Regulatory I PDR 2 -1 RPP PDR 2 P Catalog o.: RP 14C glial cells. enteric and cells cells,satellite Schwann stains it system, nervous peripheral the this antibody stains astrocytes and some groups of ependymal cells. However, in Specificity: Cellular Positive Immunogen: cidicGlial Fi rillary Protein (GF P) Polyclonal Anti-Human Rabbit amide and cholecystokinin. gastrin human gastrin, big human releasing peptide, sulfated amide,cholecystokinin non-sulfated cholecystokinin gastrin, rat cross- No with fragments. observed I was gastrin human reactivity and I gastrin human with reacts body Specificity: Cellular Positive Immunogen: Regulatory Status:Regulatory Catalog o.: RP 44C Polyclonal Anti-Human Rabbit Gastrin ------Localization: Cytoplasmic Localization: Cytoplasmic Control: Brain Control: Stomach F This antibody reacts with human GFAP. In the central nervous system, anti- This cells. gastrin-containing against specific is antibody The RP 14- 5Concentrated .5ml PDR 2 -1 RPP PDR 2 P RP 44- 5Concentrated .5ml Glial fibrillary protein isolated from cow spinal cord. Recombinant gastrin conugated Āto KLH. I oncentrated 1ml oncentrated 1ml rediluted 6ml rediluted 6ml
r eiue m rediluted 1mlĀ ediluted 1 ml 36 3 6 , F
P , P 6 Formalin fixed paraffin embeddedhumanbrain stainedwithGFAP antibody(Mob199). Formalin fixed paraffin embeddedhumanbrain stainedwithGFAP antibody(PDM008). Mob199- 5Concentrated .5ml Status:Regulatory I PDM Prediluted 6ml Catalog o.: Mob199Concentrated 1ml Clone: Regulatory Status:Regulatory I PDM -1 MMP PDM P Catalog o.: Mob 64C Clone: other intermediate filament proteins. any with cross-react not does antibody neurons. This or oligodendrocytes stain brain andspinalcord. andCNSependymalcellsbutdoesnot stains astrocytes It Specificity: Cellular Positive Isotype: Immunogen: cidicGlial Fi rillary Protein (GF P) Monoclonal MouseAnti-Human cells but not oligodendrocytes or neurons. This antibody does not react with other react intermediate not filament proteins.does antibody This neurons. or oligodendrocytes not but cells GFAP in brain and spinal cord. It labels some astrocytes and some CNS ependymal Specificity: Cellular Positive Isotype: porcine spinal cord. Immunogen: cidicGlial Fi rillary Protein (GF P) Anti-Human Monoclonal Mouse ------6F2 GA5 Localization: Cytoplasm Localization: Cytoplasm IgG1, kappa IgG1, kappa Control: Brain Control: Brain This antibody is specific to a 52 kDa intermediate filament protein in This antibody reacts with the 52 kDa intermediate filament protein filament intermediate kDa 52 the with reacts antibody This Mob 64- 5Concentrated .5ml Glial fibrillary acidic protein from human brain. AB mc wr imnzd ih la fbilr poen from protein fibrillary glial with immunized were BALBC Āmice rediluted 6ml oncentrated 1ml rediluted 1mlĀ 36 F F , , P P 2/17/17 5:04PM Primary Antibodies 2/17/17 5:04 PM NEW www.dbiosys.com H P P
, , 3 6 F rediluted 1ml Ā rediluted F
oncentrated 1ml oncentrated 1ml I Recombinant human glycophorin A protein. A glycophorin human Recombinant BALBC Āmice were immunized with formalin fixed membrane from from membrane fixed formalin with immunized were BALBC Āmice Mob 66- 5 Concentrated .5ml Mob 66- 5 Concentrated This antibody is specific to erythroid cells at various stages of This antibody recognizes a sialoglycoprotein of a 39kDa, This sialoglycoprotein antibody identified recognizes as IgG1, kappa IgG1, Placenta Control: Tonsil Control: IgG1, kappa IgG1, Cell surface Cell Localization: Cell membrane Cell Localization: DBM15.1 C159 ------Monoclonal Mouse Anti-Human Monoclonal Monoclonal Mouse Anti-Human C 3 a Glycophorin Clone: Mob4 3 C o.: Catalog PDM196-1 MM P I Regulatory Status: 6ml PDM196 Prediluted Immunogen: Isotype: Positive Cellular Specificity: precursor erythroid and (RBC) cells blood red on present is It (GPA). A glycophorin and virus Sandei for receptor the as acts glycophorin that shown been has It cells. parvovirus. Glycophorins A (GPA) and B (GPB) are single, trans-membrane Glycophorin Glycophorin Clone: Mob 66 C o.: Catalog 6ml Prediluted PDM124 Regulatory Status: Immunogen: leukemia. cell hairy a Isotype: Positive Cellular Specificity: cell. red mature the to erythroblast the from differentiation sialoglycoproteins. GPA is the carrier of blood M group and N while GPA specificities, sialoglycoproteins. GPB accounts for S and U specificities. GPA and fusion, GPB cell provide to barrier cells a provides with this suggested a been has large it and surface like mucin circulation. the in cells blood red between aggregation minimizing so Formalin fixed paraffin embedded human placenta stained with Glycophorin A antibody (Mob066). stained with Glycophorin embedded human placenta paraffin fixed Formalin Formalin fixed paraffin embedded human placenta stained with Glycophorin A/CD235a (Mob483). with Glycophorin stained embedded human placenta paraffin fixed Formalin 69 H P , H F P
, (Only for markets outside the U.S. For U.S. market, see index III.) see index market, U.S. For outside the U.S. markets for (Only (Only for markets outside the U.S. For U.S. market, see index III.) index see market, U.S. For outside the U.S. markets for (Only oncentrated 1ml oncentrated 1ml I I A synthetic peptide derived from C-terminal of human GLUT-1. human of C-terminal from derived peptide synthetic A A synthetic peptide derived from the C-terminus region of the RP12 - 5 Concentrated .5ml RP12 - 5 Concentrated RP 5- 5 Concentrated .5ml RP 5- 5 Concentrated This antibody reacts with a 55 kDa protein. Glucose is fundamental to fundamental is Glucose protein. kDa 55 a with reacts antibody This This antibody reacts with a 65 kDa protein, known as glutamate F Breast carcinoma Breast Control: Pancreas Control: Cytoplasmic Localization: Cytoplasmic Localization: ------Immunogen: Positive Cellular Specificity: the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response in insulin and IGF-1 is induced detectablesignaling. GLUT-1 in many human tissues including those of the colon, lung, stomach, esophagus and breast. GLUT-1 Polyclonal Rabbit Anti-Human Polyclonal GLU - Immunogen: protein. GAD65 human Positive Cellular Specificity: GAD6, Āwhich and GAD65 adults, in exist GAD of forms Two (GAD). decarboxylase GABA most in expressed GAD6 Āare and GAD65 genes. different by encoded are nerveand membrane the to targeted be to appears GAD65 neurons. containing cell. the throughout distributed widely more GAD6 Āis as where ending, Polyclonal Rabbit Anti-Human Polyclonal (G ) ecar oxylate Glutamate RP12 C o.: Catalog Regulatory Status: RP 5 C o.: Catalog Regulatory Status: Regulatory Status: immunoreactivity in some behavior. cancers, aggressive including with associated been trans-carcinoma has of bladder, the urinary Formalin fixed paraffin embedded human bladder stained with GLUT-1 antibody (RP128). embedded human bladder stained with GLUT-1 paraffin fixed Formalin Formalin fixed paraffin embedded human pancreas stained with GAD65 antibody (RP075). embedded human pancreas stained paraffin fixed Formalin Page 67-71 Hard Edit.pdf 3 Page 67-71 Hard Edit.pdf 4 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithGranulocyte antibody(Mob268). Formalin fixed paraffin embeddedhumantonsilstainedwithGlycophorin Cantibody(Mob067). Mob 6 - 5 Concentrated .5ml Status:Regulatory I Catalog No. Mob 6 Concentrated1ml Clone: Glycophorin C Monoclonal MouseAnti-Human detection detection of myeloid leukemia and granulocytic sarcoma. precursor and mature forms of human myeloid cells. This antibody is useful in the withearly ofcellsinhumantissues.AntibodycloneBM2reacts with othertypes Specificity: Cellular Positive Isotype: mitogen stimulated human peripheral blood lymphocytes. Monoclonal MouseAnti-Human Regulatory Status:Regulatory I Catalog o.: Mob26 C Clone: Immunogen: Granulocyte is one of four sialic acid-rich polypeptides. glycophorin C. Glycophorin C is found on the human erythrocyte membrane and Specificity: Cellular Positive Isotype: Immunogen: ------Ret4 f BM-2 Localization: Cytoplasmic Localization: Cell membrane IgG1 IgG1, kappa Control: Tonsil Control: Tonsil This antibody is specific to mature granulocytes. It does not react react not does It granulocytes. mature to specific is antibody This hs nioy s pcfc to specific is antibody This PDM 4-1 MMP PDM 4P Mob26 - 5Concentrated .5ml BALB Cmice were in ected with red cell ghosts. BALB C F oncentrated 1ml ie ee muie wt nce fo pokeweed from nuclei with immunized were mice rediluted 6ml F r ediluted 1 ml ilgyohrn lo nw as known also sialoglycophorin 3 6 , ,
P P .. adenoma. adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular follicular of that than higher significantly is carcinoma follicular in GPC3 of Expression ye o canc of types patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain certain in enhanced dramatically is GPC3 of expression cancer, thyroid with patients hepatoblastoma, with a low or undetectable expression in normal normal in expression undetectable or low a with hepatoblastoma, expression is also found in some of types tumors, embryonal such as subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 GPC3 of level high A choriocarcinoma. and tumors sac yolk specifically subtypes, testicular germ cell tumors, GPC3 expression is up regulated in certain histologic histologic certain in regulated up is expression GPC3 tumors, cell germ testicular areas of hepatic adenoma (HA) with malignant transformation. In the context of of context the In transformation. malignant with (HA) adenoma hepatic of areas tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and and nodules dysplastic as such lesions focal with liver or liver cirrhotic in than tissue the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver liver HCC in higher be to found also is expression GPC3 donors. healthy of serum the liver tissue and elevated in serum, but is undetectable in normal liver,normal in undetectable is but elevated serum, and liver in tissue benign liver, and (RMAB102). Formalin fixed paraffin embeddedhumanhepatocellular carcinoma stainedwithGlypican-3 Formalin fixed paraffin embedded human hepatocellular carcinoma stained with Glypican-3 (Mob497). Glypican-3 with stained carcinoma hepatocellular human embedded paraffin fixed Formalin tumors, and and tumors, hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell cell germ testicular melanoma, hepatoblastoma, (HCC), carcinoma hepatocellular Specificity: Specificity: Cellular Positive Isotype: Immunogen: Immunogen: RM Status:Regulatory I Catalog o.: RM Clone: Glypican-3 (GPC3) Anti-Human Monoclonal Rabbit Catalog o.: Mob49 C Clone: Glypican-3 (GPC3) Monoclonal MouseAnti-Human Regulatory Status:Regulatory I in normal liver, benign liver, and the serum of healthy donors. overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable and tumors, cell germ testicular igoi o hptclua crioa HC, eaolsoa melanoma, hepatoblastoma, (HCC), carcinoma hepatocellular of diagnosis Specificity: Cellular Positive Isotype: Immunogen: ------DBR16.1 DBM15.2
Localization: Rabbit IgG Control: Localization: Cytoplasmic IgG1, kappa Control: Thyroid carcinoma, hepatocellular carcinoma Anti-GPC3 Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of niGC hs en dniid s ueu tmr akr o the for marker tumor useful a as identified been has Anti-GPC3 RMPD1 2-1 RMP RMPD1 2P PDM21 -1 MMP PDM21 P Recombinant Recombinant full-length human GPC3 protein. Recombinant full-length human GPC3 protein. ers ilm Hepatocellular carcinoma s AB1 2-1 C AB1 2 Concentrated .5ml
1 tumor. In patients with HCC, GPC3 is overexpressed in neoplastic neoplastic in overexpressed is GPC3 HCC, with patients In tumor. Cytoplasmic in follicular carcinoma and and carcinoma follicular in rediluted 6ml oncentrated 1ml F F rediluted 6ml oncentrated 1ml r r ediluted 1 ml ediluted 1 ml ilms uo. n ains ih C, P3 is GPC3 HCC, with patients In tumor. 3 6 3 6 , ,
P P H in papillary carcinoma. carcinoma. papillary in H ad ac ilm ent tissue. In In tissue. ent s tumor and NEW NEW 2/17/17 5:04PM Primary Antibodies 2/17/17 5:04 PM NEW www.dbiosys.com H P/H of cases of high grade B cell B grade high of cases of P
,/ , 35 3 6 3 6 of hairy cell leukemia cases. This 9 ediluted 1 ml r F oncentrated 1ml rediluted 6ml rediluted Cytoplasmic Pituitary DEAU cell line established from a large cell lymphoma. cell large a from established line cell DEAU A recombinant human Growth Hormone (GH) fragment (aa5 -1 ). Mob2 - 5 Concentrated .5ml Mob2 - 5 Concentrated This antibody reacts with a subset of B-lymphocytes localized in the in localized B-lymphocytes of subset a with reacts antibody This Pituitary growth hormone (GH) plays a crucial role in stimulating and Tonsil Control: IgM, kappa IgM, Cell membrane, cytoplasmic membrane, Cell Localization: IgG Control: Localization: DBA.44 DBM15.41 ------lymphomas. Immunogen: Isotype: Positive Cellular Specificity: follicular mantle zone. It about of staining reacts positive strong shows with antibody Monoclonal Mouse Anti-Human F Leukemia Hairy Cell Monoclonal Mouse Anti-Human Monoclonal Hormone Gro th Immunogen: Clone: Mob2 C No.: Catalog PDM 24 P PDM 24-1 MM P Clone: 1ml Mob515 Concentrated No.: Catalog IVD Regulatory Status: 6ml PDM25 Prediluted PDM25 -1 MMPrediluted 1 ml Specificity: Isotype: Positive Cellular Regulatory Status: IVD Regulatory Status: controlling controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve involve andGHR, membrane-bounditsreceptor, to GH of binding the by mediated a phosphorylation cascade that results in the modulation of numerous signaling pathways. pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly). disease pituitary of study the Formalin Formalin fixed paraffin embedded human tonsil stained with Hairy Cell antibodyLeukemia (PDM024). Formalin fixed paraffin embedded human pituitary paraffin stained with Growth Hormone (Mob515). fixed Formalin 1 of all of NEW H P ,/ F H P
,/ 3 6 rediluted 6ml rediluted Cytoplasmic (Golgi bodies) and Secreted and bodies) (Golgi Cytoplasmic oncentrated 1ml Breast carcinoma Breast F A synthetic peptide from the N-terminus of human granzyme B. granzyme human of N-terminus the from peptide synthetic A Recombinant human GCDFP-15 protein fragment (aa 41-146). (aa fragment protein GCDFP-15 human Recombinant RP1 5- 5 Concentrated .5ml RP1 5- 5 Concentrated This antibody reacts with a 32 kDa protein. Granzymes are neutral It recognizes a protein of 15kDa, identified as Gross cystic disease fluid disease cystic Gross as identified 15kDa, of protein a recognizes It Tonsil Control: Control: Cytoplasmic Localization: IgG2a, kappa IgG2a, Localization:
DBM15.52 ------Immunogen: Monoclonal Mouse Anti-Human Protein-15 Disease Fluid Cystic Gross (GCDFP-15) Immunogen: Positive Cellular Specificity: serine proteases, which are G) stored to (A in granzymes of number specialized A cells. (NK) killer lytic natural in and granules (CTL) lymphocytes of cytotoxic T have been isolated and cloned. Human granzyme B is involved in target cell Polyclonal Rabbit Anti-Human Polyclonal Granzyme B Clone: 1ml Mob526 Concentrated No.: Catalog 6ml PDM261 Prediluted PDM261-1 MMPrediluted 1 ml P PDR 5 RP1 5 C No.: Catalog IVD Regulatory Status: Isotype: Positive apoptosis during lymphocytemediated cytotoxicity. This antibody is useful in the in useful is antibody This cytotoxicity. lymphocytemediated during apoptosis characterization the for and granules lytic containing granzymeB of localization cells. NK or CTL activated of Regulatory Status: IVD Regulatory Status: Cellular Specificity: protein protein 15 (GCDFP-15). It is a ma.or protein component of benign breast gross cysts. It is a known marker of breast cancer, as it is found in approximately 5 approximately in found is it as cancer, breast of marker known a is It cysts. breast breast cancer specimens. GCDFP-15, also known as PIP, for prolactin inducible protein, protein, is a prolactin and androgen This controlled protein. antibody is useful in the identification of metastatic breast carcinoma, or fluid analysis. fluid or carcinoma, breast metastatic of identification the Formalin fixed paraffin embedded human breast carcinoma stained with GCDFP-15 (Mob526). stained with GCDFP-15 embedded human breast carcinoma paraffin fixed Formalin Formalin fixed paraffin embedded human Hodgkin’s lymphoma fixed paraffin Formalin stainedembedded withhuman GranzymeHodgkin’s B antibody (RP105). Page 67-71 Hard Edit.pdf 5 Page 72-76 Hard Edit.pdf 1 Primary Antibodies www.dbiosys.com antibody (Mob269). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithHeatShockProtein 70 Formalin fixed paraffin embeddedhumanplacenta stainedwithHCG-beta (Mob531). Regulatory Status:Regulatory I PDM2 -10MMPrediluted 10ml PDM2 Prediluted ml Catalog o.: Mob531Concentrated 1ml Clone: HC - eta Monolonal MouseAnti-Human tumors tumors may indicate aggressive behavior. s uamous demonstrate demonstrate anti-hCG in positivity hroacnm. ag cl crioa n aeoacnm o te lung the of adenocarcinoma and carcinoma cell Large choriocarcinoma. hormone (LH). hCG Mab detects cells and tumors of trophoblastic origin such as as such origin trophoblastic of tumors and cells detects Mab hCG (LH). hormone stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing luteinizing and (FSH), hormone stimulating follicle (TSH), hormone stimulating designated as the α and β subunits. The α subunit is identical to that of thyroid of that to identical is subunit α The subunits. β and α the as designated composed of two non-identical, non-covalently linked polypeptide chains chains polypeptide linked non-covalently non-identical, two of composed amounts amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is drugs and other damaging conditions. secreted in large large in secreted been shown to be involved in protective roles against thermal stress, cytotoxic stress, thermal against roles protective in involved be to shown been actin, actin, p53, polyoma T antigen, nucleotides and other known proteins. HSP70 has (HSP72) form of HSP70. HSP70 is found to be associated with steroid receptors,steroid with associated be to found is HSP70 HSP70. of form (HSP72) Specificity: Cellular Positive Isotype: HCG. does It not cross react with the alpha HCGsub-unit. is a glycoprotein, which is Monolonal MouseAnti-Human Regulatory Status:Regulatory I Catalog o.: Mob2 C Clone: Immunogen: Heat ShockProtein (HSP ) Specificity: Cellular Localization: Cytoplasmic, Secreted Positive Control: Placenta Isotype: Immunogen: ------DBM15.57 W27 Localization: Cytoplasmic and nuclear Control: Breast carcinoma IgG2a IgG1 cell carcinomas are positive. hCG expression by non-trophoblastic non-trophoblastic by expression hCG positive. are carcinomas cell This Mab reacts with a protein of 22kDa, identified as beta sub-unit of of sub-unit beta as identified 22kDa, of protein a with reacts Mab This hs nioy s pcfc o osiuie HP3 ad inducible and (HSP73) constitutive to specific is antibody This Mob2 -05C F Recombinant hCG beta protein (HCGb/54 and HCGb/45 ). BALB/C mice were injected with purified HSP70 protein. uan tities by normal trophoblasts. It is present only in trace trace in only present is It trophoblasts. normal by tities oncentrated 1ml oncentrated 0.5ml 0% and F 0% of cases respectively. 20% of lung 3 0 , ,
P P H H NEW 72 antibody (RP016). antibody (Rp015). Formalin fixed paraffin embeddedbreastcarcinoma stainedwithHeatShockProtein 70antibody Formalin fixed paraffin embedded human stomach infected with H. pylori and stained with H. pylori pylori H. with stained and pylori H. with infected stomach human embedded paraffin fixed Formalin gastritis in humans. h eihla cls H plr i kon o as ppi ucr n chronic and ulcer peptic cause to known is pylori H. cells. epithelial the the bacteria present on the surface of the epithelium or in the cytoplasm of Polyclonal Anti-Human Rabbit RP015-05Concentrated 0.5ml Status:Regulatory I Catalog o.: RP015Concentrated 1ml HSP73). It stains epithelial cells in many different tissues (e.g. tonsil, stomach, small tonsil,and large(e.g. intestine, tissues bile different ducts, many ovary in and prostate). cells epithelial stains It HSP73). Specificity: Cellular Positive Immunogen: Heat ShockProtein (HSP ) Polyclonal Anti-Human Rabbit Specificity: Cellular Positive Immunogen: Status:Regulatory I PDR053-10RPPrediluted 10ml PDR053Pr Catalog o.: RP01 C pyloriHelico acter F ------Localization: Cytoplasmic, nuclear Localization: Cytoplasmic Control: Breast carcinoma Control: Infected stomach This antibodyreacts withthetwo majorhumanHSP70s(HSP72and RP01 -05C This antibody reacts with the whole H. pylori. The antibody stains Purified heat shock protein (DnaK) from E. coli. Total lysate of H. pylori. oncentrated 1ml ediluted ml oncentrated 0.5ml F 3 0 , P , P 2/17/17 5:04PM Primary Antibodies 2/17/17 5:04 PM NEW www.dbiosys.com P/H P
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Liver Extract of a formalin-fixed, rejected-allograft of a human liver. human a of rejected-allograft formalin-fixed, a of Extract Human liver fixed in formalin. in fixed liver Human F Mob42 -05 C Hepatocyte Paraffin 1 or HepPar1 localizes to the mitochondria of Hepatoblastoma is Hepatoblastoma the most common primary tumor of the liver in Hepatocellular carcinoma Hepatocellular Control: Control: IgG1 IgG1 Finely granular cytoplasmic granular Finely Localization: DBM15.50 OCH1E5 ------Positive Localization: Cellular Specificity: Monoclonal Mouse Anti-Human HepPar-1 Immunogen: Isotype: Positive Cellular Specificity: carcinomas hepatocellular distinguishing for marker sensitive a is It hepatocytes. (HCC) from other metastatic carcinomas as well as cholangio-carcinomas, HCC’s The organs. other many in found also are they but stomach, the in primarily occur Hepatocyte Specific Antigen may also be a useful marker for intestinal Monoclonal Mouse Anti-Human Monoclonal Hepatocyte Specific Antigen Immunogen: Isotype: children. The use of specific hepatocyte markers and also of carcinoembryonic α antigen fetoprotein or are useful for the identification of normal and Clone: 1ml Mob524 Concentrated No.: Catalog PDM25 Prediluted ml 10ml PDM25 -10MM Prediluted Clone: Mob42 C No.: Catalog IVD Regulatory Status: PDM1 2 P PDM1 2 IVD Regulatory Status: metaplasia. Reportedly, strong expression of the Hepatocyte Specific Antigen correlates with smaller few a in tumor as well as carcinomas size gastric in found also and is Antigen Specific Hepatocyte longer patient survival. Occasionally, tumors. non-hepatic other malignant fetal hepatocytes. This antibody recognizes an uncharacterized antigen antigen uncharacterized an recognizes antibody This hepatocytes. fetal malignant present in both adults and fetal normal hepatocytes to produce a distinct granular granular distinct a produce to hepatocytes normal fetal and adults both in present carcinomas. hepatocellular of majority stains antibody This staining. cytoplasmic Formalin Formalin fixed paraffin embedded human hepatocellular carcinoma stained with HepPar-1 (Mob524). Formalin Formalin fixed paraffin embedded liver stained with Hepatocyte Specific Antigen antibody (Mob426). 73 P , P , F F
RUO HBcAg HBcAg purified from the lysates of E. coli infected with the viral Purified HBsAg subtype ayw3. subtype HBsAg Purified This antibody stains the cytoplasm of antigen-positive liver cells in This antigen reacts in the nuclei of the liver cells of the hepatitis type B type hepatitis the of cells liver the of nuclei the in reacts antigen This
Infected liver Infected Control: Infected liver Infected Control: Nuclear Localization: IgG1 Cytoplasmic Localization: 3E7 ------Hepatitis B Core Antigen (HBcAg) Antigen B Core Hepatitis RP017R Concentrated 1ml RP017R Concentrated No.: Catalog RUO Regulatory Status: 0.5ml Concentrated RP017-05R ediluted ml PDR020R Pr Polyclonal Rabbit Anti-Human Polyclonal Immunogen: Hepatitis B Surface (HBsAg)Hepatitis Antigen Immunogen: core DNA. core Positive Cellular Specificity: virus infected patients. However, occasional staining may cells. also infected be the of seen cytoplasm in perinuclear the Clone: 1ml Mob125R Concentrated No.: Catalog PDM07 R Prediluted ml Regulatory Status: 0.5ml Mob125-05R Concentrated Monoclonal Mouse Anti-Human patients with Type B viral hepatitis. This antibody reacts with the ‘a’ determinant ‘a’ This antibody reacts B with viral hepatitis. the Type patients with Isotype: Positive Cellular present on the HBsAg subtypes ayw1, ayw2, ayw3, ayw4, ayr, adw2, adw4 and adr. adr. and adw4 adw2, ayr, ayw4, ayw3, ayw2, ayw1, subtypes HBsAg the on present Specificity: It does not react with normal tissues. normal with react not does It Formalin fixed paraffin embedded infected liver stained with HBsAg antibody (Mob125R). embedded infected liver stained with HBsAg paraffin fixed Formalin Formalin fixed paraffin embedded infected liver stained with HBcAg antibody (RP017R). HBcAg embedded infected liver stained with paraffin fixed Formalin Page 72-76 Hard Edit.pdf 2 Page 72-76 Hard Edit.pdf 3 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedbreastcarcinoma stainedwithHER2/neuantibody(RMAB026). (RMAB049). antibody Her2/Erb2 with stained cancer breast human embedded paraffin fixed Formalin proteins. Overexpression of ErbB2 is detected in almost 40% of human breast cancers. activated without ligand if it is overexpressed, and by association with other ErbB ErbB other with association by and overexpressed, is it if ligand without activated E2nu Oeepeso as ocr i ohr acr uh s osteosarcoma,ovarian cancer as and stomach such cancer. cancer other in occurs also Overexpression HER2/neu. be can ErbB2 of activity kinase The kinases. tyrosine receptor-like transmembrane eas o is rgotc oe s el s t aiiy o rdc rsos to response predict of to overexpression for ability checked its routinely as are tumors well breast as trastuzumab, role prognostic its of Because Specificity: acr s soitd ih nrae dsae eurne n wre prognosis. worse and recurrence disease increased with associated is cancer breast in receptor this of Overexpression product. protein its of overexpression Cellular Positive Isotype: human Her2 protein. ecn o bes cnes ae n mlfcto o te E2nu ee or gene HER2/neu the of amplification an have cancers breast of percent chromosome human of arm long the pathways transduction located on growthcell to proto-oncogene differentiation.leading a and is HER2 signal the in involved normally is and kinase tyrosine of breast cancer and as a target of treatment. It is a cell membrane surface-bound growth factor receptor (EGFR) family and is notable for its role in the pathogenesis Specificity: Cellular Positive Isotype: Immunogen: Status:Regulatory Catalog No.: RM Clone: HER2/neu Anti-Human Monoclonal Rabbit Immunogen: Status:Regulatory Catalog No.: RM Clone: Her2/Erb2 Anti-Human Monoclonal Rabbit ------BV5 EP3
Localization: Rabbit IgG Control: Localization: Cell Membrane IgG Control: HER2 /ErbB2 is one of the four members of the ErbB receptor family of HER2/neu (also known as c-erbB-2) is a member of the epidermal the of member a is c-erbB-2) as known (also HER2/neu RMPD02 P RMPD04 P F A synthetic peptide corresponding to residues near the C-terminus of of C-terminus the near residues to corresponding peptide synthetic A A synthetic cyclic peptide from the antigen C-terminus. F Breast carcinoma AB02 C AB04 C Breast carcinoma IVD IVD Cell Membrane r r oncentrated 0.5ml oncentrated 0.5ml (Only for markets outsi etheU.S. For U.S. market, seein ex III.) (Only for markets outsi etheU.S. For U.S. market, seein ex III.) ediluted ml ediluted ml 17(17 11.2- , ,
P 2.ĀApoiaey 25-30 Approximately 12). Ā P 74 Formalin fixed paraffin embeddedprostatecarcinoma stainedwithHeregulinantibody(Mob343). Formalin fixed paraffin embeddedhumaninfectedtissuestainedwithHSVIantibody(PDM080). Monoclonal MouseAnti-Human Mob343-05Concentrated 0.5ml Status:Regulatory Catalog No.: Mob343Concentrated 1ml Clone: n amr ad ernl el wt lw n hg afnte, respectively. that differ affinities, in their EGFlike high domain and in and β and receptor α groups, twobinding in low affinity.classified are which isoforms, several in with exists HRG/NDF cells neuronal and mammary on receptors c-erbB-4 and c-erbB-3 to binds Heregulin (NDF). differentiationfactor Specificity: Cellular Positive Isotype: domain of rat NDF protein. Immunogen: Heregulin/ NDF/GGF/Neuregulin zoster virus, mumps virus and varicella- measles HSV2, adenovirus,virus. 4b, and 1,2,3 type virus arainfluenza B, and A type virus influenza RSV, of isolates culture tissue with cross-reaction any show not crossreacts withsomestrainsofpoliovirustype2andCMVstrainAD1 .Idoes Specificity: Cellular Positive Isotype: virus type 1. Immunogen: Regulatory Status:Regulatory Catalog No.: PDM080Pr Clone: Herpes Simplex Virus Type I(HSV1) Monoclonal MouseAnti-Human ------7D5 20.7.1 Localization: Cytoplasmic, intercellular spaces Localization: Cytoplasmic, nuclear IgG2a IgG1, kappa Control: Prostate carcinoma Control: Infected lung This antibody reacts with a 44 kDa protein known as heregulin or neu This antibodyreacts 1. withherpessimplexvirustype This antibody BALB/C mice were immunized with Stoker strain of herpes simplex BALB/C mice were injected with a recombinant extracellular extracellular recombinant a with injected were mice BALB/C IVD IVD ediluted ml
(Only for markets outsi etheU.S. For U.S. market, seein ex III.) F F ,/ P , H P 2/17/17 5:04PM Primary Antibodies 2/17/17 5:04 PM www.dbiosys.com H P P , ,/ F F 3 0 (Only for markets outsi e the U.S. For U.S. market, see in ex III.) see in ex market, U.S. For outsi e the U.S. markets for (Only (Only for markets outsi e the U.S. For U.S. market, see in ex III.) see in ex market, U.S. For outsi e the U.S. markets for (Only ediluted ml ediluted ml Cytoplasmic, nuclear Cytoplasmic, IVD IVD Infected tissue Infected BALB/C mice were immunized with Parker strain of herpes simplex herpes of strain Parker with immunized were mice BALB/C Whole rabbit corneal cells, infected with herpes simplex virus type I type virus simplex herpes with infected cells, corneal rabbit Whole This antibody reacts with herpes simplex virus type 2. It does not This antibody reacts with HSV type I and II specific antigens and with and antigens specific II and I type HSV with reacts antibody This Control: Infected lung Infected Control: 12.3.4, IgG1, lambda; 1.1.1, IgG1, kappa IgG1, 1.1.1, lambda; IgG1, 12.3.4, Localization: Cytoplasmic, nuclear Cytoplasmic, Localization:
12.3.4 1.1.1 ------Specificity: Immunogen: detergent. with solublized were M5), (strain II type and Intyre) Mac (strain Positive Cellular antigens antigens common to HSV type I and II virus. It reacts with all the major glycoproteins present in the viral envelope as well as with at least one core protein. core one least at with as well as envelope viral the in present glycoproteins Polyclonal Rabbit Anti-Human Polyclonal I & II Type Virus Herpes Simplex (HSV1 & HSV2) PDR034 Pr No.: Catalog 10ml PDR034-10RP Prediluted Regulatory Status: Monoclonal Mouse Anti-Human Monoclonal (HSV2) II Type Virus Herpes Simplex Clone: PDM081 Pr No.: Catalog Regulatory Status: Immunogen: virus type 2. type virus Isotype: Positive Cellular Specificity: A type virus influenza RSV, of isolates culture tissue with cross-reaction any show and B, parainfluenza virus type 1,2,3 and 4b, adenovirus, HSV1, varicella-zoster virus. measles and virus mumps virus, Formalin fixed paraffin embedded human infected tissue stained with HSV 1 & 2 (PDR034). paraffin fixed Formalin Formalin fixed paraffin embedded human infected tissue stained with HSV II antibody (PDM081). paraffin fixed Formalin 75 P , P F , F (Only for markets outsi e the U.S. For U.S. market, see in ex III.) see in ex market, U.S. For outsi e the U.S. markets for (Only (Only for markets outsi e the U.S. For U.S. market, see in ex III.) in ex see market, U.S. For outsi e the U.S. markets for (Only oncentrated 0.5ml oncentrated 1ml Cytoplasmic, nuclear Cytoplasmic, IVD IVD Infected tissue Infected Whole rabbit corneal cells, infected with herpes simples virus type I type virus simples herpes with infected cells, corneal rabbit Whole Whole rabbit corneal cells, infected withinfectedherpes cornealrabbitWhole cells, simplexvirus type I RP1 2-05 C This antibody reacts with HSV type I and II specific antigens and with and antigens specific II and I type HSV with reacts antibody This Infected tissue Infected Control: Control: Cytoplasmic and nuclear and Cytoplasmic Localization: Localization:
------Immunogen: Herpes Simplex Virus Type I & II (HSV1 & 2)Type Virus Herpes Simplex Immunogen: Polyclonal Rabbit Anti-Human Polyclonal RP1 2 C No.: Catalog
Regulatory Status: (strain Mac Intyre) and type II (strain M5), were solubilized with detergent. with solubilized were M5), (strain II type and Intyre) Mac (strain Positive Cellular Specificity: antigens common to HSV type I and II virus. It reacts with all major glycoproteins glycoproteins major all with reacts It virus. II and I type HSV to common antigens protein. core one least at with and envelope viral the in present (strain Mac Intyre), were solubilized with detergent. with solubilized were Intyre), Mac (strain Positive Cellular Polyclonal Rabbit Anti-Human Polyclonal Herpes Simplex Virus Type I (HSV1)Type Virus Herpes Simplex RP018 Concentrated 1ml RP018 Concentrated No.: Catalog ediluted ml Pr PDR032 Regulatory Status: 0.5ml RP018-05 Concentrated Specificity: This antibody reacts with HSV type I specific antigens and with antigens common to HSV type I and II virus. It reacts with all the major glycoproteins present in the viral envelope as well as with at least one core protein. core one least at with as well as envelope viral the in present glycoproteins Formalin fixed paraffin embedded human infected tissue stained with HSV 1 & 2 antibody (RP162). paraffin fixed Formalin Formalin fixed paraffin embedded human infected tissue stained with HSV I antibody (RP018). embedded human infected tissue stained paraffin fixed Formalin Page 72-76 Hard Edit.pdf 4 Page 72-76 Hard Edit.pdf 5 Primary Antibodies www.dbiosys.com Cultured cells infectedwithHHV8stainedantibody(Mob395). Formalin fixed paraffin embeddedhumaninfectedtissuestainedwithHSVIIantibody(RP019). nies omn o S tp I n I vrs I rat wt al h major the all with reacts It virus. II and I glycoproteins type present in HSV the viral envelope to as well as common with at least antigens one core protein. Specificity: Cellular Positive (strain M5), were solubilized with detergent. Regulatory Status:Regulatory Catalog o.: Mob3 5C Clone: Status:Regulatory PDR033Pr RP01 -05C Catalog o.: RP01 C which may be related to its is oncogenic activity. LNA 73. ORF gene product, gene susceptibility retinoblastoma with complex a forming of viral capable the of product the is which (LNA), antigen nuclear HHV8 is the likely etiological agent of Kaposi sarcoma (KS). HHV8 encodes a latent Specificity: Cellular Positive Isotype: 1 molecule of HHV8. Immunogen: Herpesvirus (HH ) Anti-Human Monoclonal Rat Immunogen: Herpes Simplex irus ype II(HS ) Polyclonal Anti-Human Rabbit ------LN53
Localization: Localization: Nuclear IgG2c Control: Control: Karposi sarcoma hs nioy ecs ih S tp I seii atgn ad with and antigens specific II type HSV with reacts antibody This This antibody stains with ORF-73 of human herpesvirus 8 (HHV8). 8 herpesvirus human of ORF-73 with stains antibody This Mob3 5-05C Recombinant protein corresponding to the latent nuclear antigen- Whole rabbit corneal cells, infected with herpes simplex virus type II Infected tissue I I oncentrated 1ml Cytoplasmic, nuclear oncentrated 1ml ediluted ml oncentrated 0.5ml (Only for markets outsidetheU.S. For U.S. market, seeindex III.) (Only for markets outsidetheU.S. For U.S. market, seeindex III.) oncentrated 0.5ml 3 0 F , P F , P 7 Formalin fixed paraffin antibody(Mob069R). embeddedhumantonsilstainedwithHLA-DR Formalin fixed paraffin embedded cervical carcinoma stained with HPV-16 antibody (PDM256) antibody HPV-16 with stained carcinoma cervical embedded paraffin fixed Formalin specimens specimens or smears containing HPV HPV reacts very strongly with formalin-fixed, paraffin-embedded tissues containing containing tissues paraffin-embedded formalin-fixed, with strongly very reacts are are strongly associated with cervical, vaginal, and vulvar malignancies. The antibody associated associated with relatively benign diseases such as genital warts but types increased risk of developing cervical neoplasia. HPV types . and 11 have been been have 11 and . types HPV neoplasia. cervical developing of risk increased Specificity: Cellular Positive Isotype: Catalog o.: Mob0 RC Clone: PDM25 Prediluted ml Catalog o.: Mob521Concentrated 1ml Clone: Status:Regulatory PDM082RPr polymorphs but stains activated T cells. cells and many macrophages. This antibody does not react with normal T cell and regions DP, Specificity: Cellular Positive Isotype: Immunogen: HL - R (βchainof P, R) Immunogen: Immunogen: HP -1 F Monoclonal MouseAnti-Human Monoclonal MouseAnti-Human Regulatory Status:Regulatory ------1 or -33; very weak reactions were occasionally observed with biopsy biopsy with observed occasionally were reactions weak very -33; or CR3/43 DBM15.47
Localization: IgG2a, kappa Localization: Cell membrane Control: IgG1, kappa Control: Tonsil D Infection with specific types of HPV has been associated with an an with associated been has HPV of types specific with Infection This antibody reacts with the β chain of all products of the gene sub Mob0 -05RC PDM25 -10MM P Human Human papilloma virus 1 , type major capsid protein L1. Tonsil cells. , and DR. It stains B cells, interdigitating reticulum cells, Langerhans Cervical cancer I RUO Nuclear oncentrated 1ml ediluted ml (Only for markets outsidetheU.S. For U.S. market, RUO.)
oncentrated 0.5ml rediluted 10ml - or HPV-11. It cross-reacts with HPV37. F 3 0 , , P P H H 1 and 18 NEW 2/17/17 5:04PM Primary Antibodies 2/17/17 5:05 PM www.dbiosys.com P/H P
,/ , 3 6 rediluted 1ml Ā rediluted rediluted 6ml rediluted oncentrated 1ml oncentrated 1ml IgD isolated from a pool of normal human plasma. human normal of pool a from isolated IgD IgA isolated from a pool of normal human sera. human normal of pool a from isolated IgA RP 2 - Concentrated . ml RP 2 - Concentrated RP 21- Concentrated . ml RP 21- Concentrated This antibody reacts with the Ā chain of human IgD. Traces of This antibody reacts with α-chains of human This IgA. antibody has Tonsil Control: Tonsil Control: Cytoplasmic Localization: Cytoplasmic Localization: F ------Polyclonal Rabbit Anti-Human Polyclonal P PDR 17 P PDR 17-1 RP I D egulatory Status: IgD F Immunogen: Positive Cellular Specificity: contaminating antibodies have been removed by solid phase adsorption. Only immunoelectrophoresis. crossed in appeared arch IgD the Polyclonal Rabbit Anti-Human Polyclonal IgA RP 2 C o.: Catalog Immunogen: Positive Cellular Specificity: specificity. of level high very a to adsorbed been I D egulatory Status: RP 21 C o.: Catalog Formalin fixed paraffin embedded human tonsil stained with IgD antibody (RP021). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with IgA antibody (RP020). paraffin fixed Formalin 77 H protein. P ,/ 3 - 26 F (Only for markets outside the U.S. For U.S. market, see index III.) see index market, U.S. For outside the U.S. markets for (Only (Only for markets outside the U.S. For U.S. market, see index III.) index see market, U.S. For outside the U.S. markets for (Only oncentrated 1ml Nuclear I D I D HP Ātype 16 infected cervix infected 16 HP Ātype ted with hHIF-1α aa Ā hHIF-1α with in ected were A C mice -16 1 Āprotein. HP -16 recombinant with immunized were A C mice Mob3 4- Concentrated . ml Mob3 4- Concentrated This antibody is specific to a 12 ĀkDa protein HIF-1, which is a This antibody stains with HP Ātype is 16. 1 Āprotein a maor Ācapsid Mammalian cells Mammalian Control: IgG1, kappa IgG1, Nuclear Localization: IgG2a Localization:
O 12 CAM IR-1 ------Immunogen: Isotype: Positive Cellular Specificity: heterodimer consisting of an α and a β subunit. HIF-1 is a key component chelation. of iron and a ions cobaltous hypoxia, by activated response transcriptional genes. hypoxia-inducible of transcription activates HIF-1 Hypoxia-Induci le Factor-α (HIF-1α) F Factor-α Hypoxia-Induci le Immunogen: Monolonal Mouse Anti-Human Monolonal 16) 16 (HP ype irus Human Papilloma Clone: 1ml Mob311 Concentrated o.: Catalog egulatory Status: . ml Mob311- Concentrated Clone: Mob3 4 C o.: Catalog 6ml Prediluted PDM166 egulatory Status: Monolonal Mouse Anti-Human Isotype: Control: Positive Cellular Specificity: benign relatively with associated been have 11 and HP Ā6 16. HP Ātype of protein diseases such as genital warts but type 16 and 1 Āare strongly malignancies. associated with vulvar and vaginal cervical, Formalin fixed paraffin embedded human renal cell carcinoma stained with HIF-1a (Mob311). carcinoma embedded human renal cell paraffin fixed Formalin Formalin fixed paraffin embedded cervix stained with HPV-16 antibody (Mob394). embedded cervix paraffin stained with HPV-16 fixed Formalin Page 77-81 Hard Edit.pdf 1 Page 77-81 Hard Edit.pdf 2 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithIgGantibody(RP023). Formalin fixed paraffin embeddedhumantonsilstainedwithIgEantibody(RP022). antibodies have been removed by solid-phase adsorption. egulatory Status: egulatory I D PDR 1 -1 RPP PDR 1 P Catalog o.: RP 23C hs nioy ecs with reacts antibody This Specificity: Cellular Positive Immunogen: Ig the Ig Āarch appeared in crossed immunoelectrophoresis. Only adsorption. phase solid by removed been have antibodies contaminating Specificity: Cellular Positive Immunogen: Polyclonal Anti-Human Rabbit Polyclonal Anti-Human Rabbit egulatory Status: egulatory I D Catalog o.: RP 22C Ig F ------F Localization: Cytoplasmic Localization: Cytoplasmic Control: Tonsil Control: Tonsil hs nioy ecs ih h can f ua I.Ārcs of Ig.ĀTraces human of Āchain the with reacts antibody This RP 23- Concentrated . ml RP 22- Concentrated . ml IgG isolated from a pool of normal human sera. Ig Āisolated from the serum of a patient with Ig -myeloma. oncentrated 1ml oncentrated 1ml rediluted 6ml r ediluted 1 ml γ can o hmn g. Nonspecific IgG. human of -chains ,/ ,/
P P 7 Formalin fixed paraffin embedded human tonsil stained with IgG4 (RMPD056). IgG4 with stained tonsil human embedded paraffin fixed Formalin Formalin fixed paraffin embeddedhumanspleenstainedwithIgMantibody(Mob074). This antibody does not cross-react with initiate IgG1, IgG2, to or IgG3. cells effector of phagocytosis. HumanIgG4 accounts for FcgRless than 6% of the total IgG the serum level. to binding and complements activating beendetected on the heavy chains of IgG4. Its two primary effector functions are heavy chain and a hinge region that is shorter than that of IgG1. No allotypes have Specificity: Cellular Positive Isotype: of Human IgG4. Immunogen: Ig F Anti-Human Monoclonal Rabbit usually undetectable. are lymphoid complexes immune In but strongly tissues. stain cells lymphoid plasma containing human IgM tissues, in follicles Ācell stains It IgM. human Specificity: Cellular Positive Isotype: Immunogen: PDM 3P Mob 74- Concentrated . ml Catalog o.: Mob 74C Clone: Ig F Monoclonal MouseAnti-Human egulatory Status: egulatory I D egulatory Status: egulatory I D Catalog o.: RM Clone: ------R1 6 P13 Localization: Cytoplasmic Localization: Cytoplasm Rabbit IgG IgG1, kappa Control: Tonsil Control: Tonsil ua IG, n o fu sblse o IG cnan gma 4 gamma a contains IgG, of subclasses four of one IgG4, Human This antibody reacts with the heavy chain present in all types of PDM 3-1 MMP RMPD 6P
A synthetic peptide corresponding to residues in the hinge region Human lymphoid cells. A 6 Concentrated . ml rediluted 6ml oncentrated 1ml rediluted 6ml rediluted 1mlĀ 36 ,/ ,/ P P H 2/17/17 5:05PM Primary Antibodies 2/17/17 5:05 PM www.dbiosys.com P P
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oncentrated 1ml I D I D Swine insulin. Swine Human insulin. Mob4 - Concentrated . ml Mob4 - Concentrated This antibody recognizes purified insulin from the pancreas of the pancreas insulin from purified This antibody recognizes Insulin is a hormone secreted by the β cells of the islets of angerhans Ā of islets the of cells β the by secreted hormone a is Insulin Pancreas Control: IgG1 IgG1 Cytoplasmic Localization: K36aC1 2 3 ------Monoclonal Mouse Anti-Human Insulin Clone: 1ml Mob234 Concentrated Catalog No.: egulatory Status: . ml Mob234- Concentrated Immunogen: Isotype: Pancreas Control: Positive Cytoplasmic Localization: Cellular Specificity: human. from as proinsulin human, as well Monoclonal Mouse Anti-Human Monoclonal Insulin Clone: Mob4 C o.: Catalog egulatory Status: Immunogen: Isotype: Positive Cellular Specificity: in the pancreas. Insulin is a 1 Āamino acid polypeptide composed of A chains and connected Ā through the C-peptide. Insulin promotes glycogen storage, formation of triglycerides and synthesis of protein reaction has and been nucleic observed acids. with Cross- insulin containing human. from cells pancreas in fixed sections of Formalin fixed paraffin embedded human pancreas stained with Insulin antibody (Mob234). paraffin fixed Formalin Formalin fixed paraffin embedded human pancreas stained with Insulin antibody (Mob408). paraffin fixed Formalin 7
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rediluted 6ml rediluted oncentrated 1ml rediluted 6ml rediluted oncentrated 1ml I D Synthetic peptide corresponding to the 1-32 amino terminal IgM isolated from human serum of a patient. a of serum human from isolated IgM Inhibin is a dimeric glycoprotein hormone from the TGF-β family Mob43 - Concentrated . ml Mob43 - Concentrated F This antibody reacts with the mu-chains of human IgM. Nonspecific IgM. human of mu-chains the with reacts antibody This Ovary Control: Tonsil Control: IgG2a Cytoplasmic Localization: R1 F ------made of α and β subunits. This antibody recognizes the 32kDa α subunit of human of subunit α 32kDa the recognizes antibody This subunits. β and α of made inhibin. Inhibin α is expressed in a wide variety of human tissues, such as brain, prostate, adrenal, granulose cells of ovary, sertoli cells of testis and in Immunogen: inhibin. human of subunit α the of peptide Isotype: Positive Cytoplasmic Localization: Cellular Specificity: Monoclonal Mouse Anti-Human Inhi in α Immunogen: Positive Cellular Specificity: adsorption. solid-phase by removed been have antibodies Polyclonal Rabbit Anti-Human Polyclonal Ig Clone: Mob43 C o.: Catalog PDM17 P PDM17 -1 MM P egulatory Status: I D egulatory Status: RP 24 C o.: Catalog . ml RP 24- Concentrated PDR 1 P egulatory Status: egulatory Status: fetoplacental unit. fetoplacental Formalin fixed paraffin embedded human ovary stained with Inhibin α antibody (Mob435). embedded human ovary paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with IgM antibody (RP024). embedded human tonsil stained with paraffin fixed Formalin Page 77-81 Hard Edit.pdf 3 Page 77-81 Hard Edit.pdf 4 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithKappaLightChain(RMPD042). Formalin fixed paraffin embeddedhuman tonsil stainedwithKappaLightChainantibody(Mob075). antibody antibody is useful for identifying monoclonality of lymphoid malignancies. malignant proliferation. The pairing of an anti-lambda with a kappa light chain chain light kappa a with anti-lambda an of pairing The proliferation. malignant lambda light chains. Monoclonality is generally assumed to be evidence of a a of evidence be to assumed generally is Monoclonality chains. light lambda nonspecific uptake of immunoglobulin. Individual Individual immunoglobulin. of uptake nonspecific lymphocytes and plasma cells. Other cells may also express kappa light chain due to to due chain light kappa express also may cells Other cells. plasma and lymphocytes transformation. The kappa light chain antibody labels kappa light chain expressing chain light transformation. kappa labels antibody chain light The kappa kappabearing cells as lambda. However this ratio is lost during malignant malignant during lost is ratio this However lambda. as cells kappabearing rearrangement process normally produce approximately twice as many many as twice approximately produce normally process rearrangement molecule results in either a productive kappa or lambda gene. The mechanics of the the of gene. mechanics lambda The or kappa productive a either in results molecule egulatory Status: egulatory I D Catalog o.: RM Clone: Kappa Light Chain Monoclonal Rabbit Anti-Human Monoclonal Rabbit and lambda. The gene rearrangement process that generates the immunoglobulin immunoglobulin the generates that process rearrangement gene The lambda. and and and two identical light chains. There are two types of light chains designated as kappa Specificity: Cellular Localization: egulatory Status: egulatory I D Positive Isotype: PDM -1 MMP PDM P Catalog o.: Mob 7 - 1C Clone: light chains. This antibody does not react with human lambda kappa light bound as well chain. as free stains antibody staining. This of pattern meshwork The mantle zones give a mosaic pattern, while the germinal centers show a coarse Specificity: Cellular Positive Control: Tonsil Isotype: light chain protein. Immunogen: Kappa Light Chain Monoclonal MouseAnti-Human Immunogen: ------ P171 KP- 3
Rabbit IgG Control: Localization: Cytoplasm IgG2b
ch immunoglobulin molecule consists of two identical heavy chains chains heavy identical two of consists molecule immunoglobulin ach cell follicles in human lymphoid tissues. lymphoid human in follicleswith cell reacts antibody This RMPD 42P Mob 7 - 1- Concentrated . ml A recombinant protein fragment corresponding to human IgA protein. kappa ones kappa purified ence with immunized were A Cmice Tonsil, lymphoma A 42 Concentrated . ml Cytoplasmic Cell Membrane rediluted 6ml rediluted 6ml F F oncentrated 1ml r ediluted 1 ml 36 ,/ ,/ cells express either kappa or or kappa either express cells
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.. Formalin fixed paraffin embeddedhumanmelanomastainedwithKBA.62(Mob528). Formalin fixed paraffin embeddedhumantonsilstainedwithKappaLightChainantibody(RP025). Contaminating antibodies have been removed by solid phase adsorption. Specificity: Cellular Positive ence ones proteinuria. Immunogen: Polyclonal Anti-Human Rabbit egulatory Status: egulatory I D PDR 1 -1 RPP PDR 1 P Catalog o.: RP 2 C Kappa Light Chain egulatory Status: egulatory I D PDM263-1 MMP PDM263Prediluted 6ml Catalog o.: Mob 2 C Clone: B.2 KBA.62 Monoclonal MouseAnti-Human and in the context of micro-metastasis in sentinel lymph cases node.in desmoplastic spindlecell specifically melanoma, for marker additional with K A.62antibody is, with rare exception, a melanoma. Anti-K A.62 is a useful toand S1 proteinantibody with immune-reacts thatvimentin-richneoplasm keratin-negative, A neoplasms. mesenchymal of types various and carcinomas ifrnitd acnms lre el ypoa, acms side cell spindle sarcomas, lymphomas, cell large carcinomas, differentiated Metastatic amelanoticmelanomacanoften beconfused withavariety ofpoorly melanomas. malignant indentifying in useful is melanocytes. K A.62antibody nrdra nv, n aant ea mlncts u nt oml adult normal not but melanocytes fetal against and nevi, intradermal not but cells nevus against unctional positively reacts it Moreover,sensitivity. and specificity demonstrating thus tumors, other not but tumors melanocytic Cellular Positive Isotype: malignant melanoma. Specificity: Immunogen: Immunogen: ------D M1 . 4
Localization: Cytoplasmic Localization: Control: Tonsil Control: IgG1, kappa K A.62is a novel anti-melanoma antibody. It reacts positively against This antibody reacts with free as well as bound kappa light chains. light kappa bound as well as free with reacts antibody This RP 2 - Concentrated . ml ap lgt his sltd rm old rn o ptet with patients of urine pooled from isolated chains light Kappa cls eie fo lmh oe eatss of metastasis node lymph from derived cells KA Human SK-M -13 and -M -1 SK Melanoma cell lines Melanomas oncentrated 1ml Cell Surface and Cytoplasmic rediluted 6ml oncentrated 1ml F r ediluted 1 ml r ediluted 1 ml F 36 36 , ,/
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,/ 3 6 3 6 rediluted 1ml Ā rediluted rediluted 1ml Ā rediluted oncentrated 1ml rediluted 6ml rediluted oncentrated 1ml rediluted 6ml rediluted F A 1 3 Concentrated . ml A 1 3 Concentrated A 1 3-1 C Recombinant human CDH16 protein. CDH16 human Recombinant Recombinant human CDH16 protein. CDH16 human Recombinant PDM1 P PDM1 -1 MM P RMPD1 3 P P RMPD1 3-1 RM F Renal cell carcinoma cell Renal Control: Renal Cell Carcinoma Cell Renal Control: IgG1, kappa IgG1, Rabbit IgG Rabbit Cell surface with some cytoplasmic some with surface Cell Localization: Cell Surface with some cytoplasmic some with Surface Cell Localization: D M1 .14 D R16.1 ------Immunogen: Isotype: Positive Cellular Specificity: It is suggested that KSP-Cadherin is a marker for terminal Monoclonal Mouse Anti-Human KSP-Cadherin Clone: Mob4 2 C No.: Catalog IVD Regulatory Status: Monoclonal Mouse Anti-Human Monoclonal (KSP-Cadherin)/ Cadherin Kidney-Specific CDH16 Clone: RM No.: Catalog RM Immunogen: Isotype: Positive Cellular Specificity: Cadherins have been implicated in embryogenesis, tissue Regulatory Status: IVD Regulatory Status: differentiation differentiation of the membrane basolateral basolateral the in membranes exclusively of found is Ksp-Cadherin renal kidney, tubular the Within epithelial cells. of renal tubular epithelial cells and collecting duct vessels. cells, and blood or not in cells, glomeruli, interstitial renal morphogenesis, morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and invasiveness membrane transport. It is suggested that Ksp- of membranes basolateral the of differentiation terminal for marker a is cadherin exclusively found is Ksp-Cadherin kidney, the Within cells. epithelial tubular renal tubular epithelial cells and collectingin the basolateral membrane of renal duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. Formalin fixed paraffin embedded human renal cell carcinoma stained with KSP-Cadherin (PDM195). stained with KSP-Cadherin carcinoma embedded human renal cell paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with KSP-Cadherin (RMAB103). paraffin fixed Formalin 1 H P/H P
, ,/ F F 3 6 3 6 phase are negative for this protein. this for negative are phase rediluted 1ml Ā rediluted rediluted 1ml Ā rediluted oncentrated 1ml uiescent rediluted 6ml rediluted rediluted 6ml rediluted oncentrated 1ml A 4 Concentrated . ml A 4 Concentrated A 4-1 C Synthetic Synthetic peptide from 62 base pair region of the human Ki-67 A synthetic peptide from C-terminus of human Ki-67. human of C-terminus from peptide synthetic A Ki-67 is a nuclear protein, which is expressed in proliferating cells. Ki- cells. proliferating in expressed is which protein, nuclear a is Ki-67 This antibody reacts with a nuclear antigen present in proliferating Tonsil Control: Tonsil Control: IgG Nuclear Localization: Nuclear Localization: SP6 ------RMPD 4-1 RM P Immunogen: Isotype: Positive Cellular RMPD 4 P IVD Regulatory Status: RM Specificity: Clone: RM No.: Catalog Monoclonal Rabbit Anti-Human Ki-67 Immunogen: antigen. Positive Cellular human cells. It can be used to evaluate the Ki-67 labeling index in various tumors. Specificity: various in index labeling Ki-67 the evaluate to used be can It cells. human Polyclonal Rabbit Anti-Human Polyclonal Ki-67 RP 26 C No.: Catalog . ml RP 26- Concentrated PDR 4 P PDR 4 -1 RP P PDR 4 -1 RP 67 is preferentially expressed during late G1-, S-, M-, and G2-phases of G Ā the the cell in cells while cycle, IVD Regulatory Status: Formalin fixed paraffin embedded human tonsil stained with Ki-67 antibody (RMAB004). paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with Ki-67 embedded human tonsil stained with antibody (PDR048). paraffin fixed Formalin Page 77-81 Hard Edit.pdf 5 Page 82-86 Hard Edit.pdf 1 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithKu(p70) (Mob327-1). Formalin fixed paraffin embedded human tonsil stained with Lambda Light Chain antibody (RMAB043). antibody Chain Light Lambda with stained tonsil human embedded paraffin fixed Formalin useful useful for identifying monoclonality of lymphoid malignancies. malignant proliferation. The pairing of a kappa with a lambda light chain antibody is is antibody chain light lambda a with kappa a of pairing proliferation. The malignant lambda light chains. Monoclonality is generally assumed to be evidence of a a of evidence be to assumed generally is Monoclonality chains. light lambda nonspecific uptake of immunoglobulin. Individual B cells express either kappa or or kappa either express cells B Individual immunoglobulin. of uptake nonspecific transcription transcription factor Sp. lymphocytes and plasma cells. . ther cells may also express lambda light chain due to to due chain light lambda express also may cells ther . cells. plasma and lymphocytes component of the DNA-associated protein kinase that phosphorylates Pol II and and II Pol phosphorylates that kinase protein DNA-associated the of component chain antibody labels the lambda light chain that expresses normal and neoplastic B B neoplastic and normal expresses that chain light lambda the labels antibody chain transcription by virtue of its DNA binding activity, serving as the regulatory regulatory the as serving activity, binding DNA its of virtue by transcription lambda. However this ratio is lost during malignant transformation. The lambda light light lambda transformation. The malignant during lost is ratio this However lambda. replication and transcriptional activation. Ku is involved in Pol II-directed II-directed Pol in involved is Ku activation. transcriptional and replication process normally produce approximately twice as many kappabearing cells as as cells kappabearing many as twice approximately produce normally process number of functions have been proposed for Ku, including cell signaling, DNA DNA signaling, cell including Ku, for proposed been have functions of number either a productive kappa or lambda gene. The mechanics of the rearrangement rearrangement the of mechanics The gene. lambda or kappa productive a either (or (or p70) and Ku-86 or (p86). Both subunits of the Ku protein have been cloned, and a protein is localized in the nucleus and is composed of subunits referred Ku-70 subunits as to of composed is and nucleus the in localized protein is gene rearrangement process that generates the immunoglobulin molecule results in in results molecule immunoglobulin the generates that process rearrangement gene Specificity: Cellular Positive Isotype: Specificity: mapping mapping between amino acids 583-608 at the C-terminus of KU-70 of human origin. Cellular Positive Control: Isotype: Mob327-05Concentrated 0.5ml Status:Regulatory Catalog No.: Mob327-1Concentrated 1ml Clone: Immunogen: Immunogen: RMPD043Prediluted 6ml Status:Regulatory IVD Catalog No.: RMAB043 Concentrated 0.5ml Clone: Chain Lambda Light Immunogen: Ku(p70) Monolonal MouseAnti-Human Monolonal Rabbit Anti-Human Monolonal Rabbit ------H-6 EP172
Localization:
Rabbit IgG
Localization: Rabbit IgG Control:
F There are two types of light chains designated as kappa and lambda. lambda. The and kappa as designated chains light of types two are There This antibody reacts with a 70 kD protein known as Ku (p70).The Ku Ku (p70).The Ku as known protein kD 70 a with reacts antibody This A A recombinant protein fragment corresponding to human IgA protein. Ku-(p70) Ku-(p70) is a mouse monoclonal antibody specific for an epitope Tonsil, lymphoma Tonsil Cytoplasmic Cell Membrane IVD Nuclear
F ,/ ,/
P P H H 82 (Mob077). Formalin fixed paraffin embeddedhumantonsilstainedwithLambdaLightChainantibody (Mob201). Formalin fixed paraffin embeddedhumantonsilstainedwithLambdaLightChainantibody pattern of staining. meshworkcoarse a showcentersgerminal the while labeling of patternmosaic lymphomas. chain. It stains B cell follicles in human lymphoid tissues. The mantle zone shows a Positive Isotype: Immunogen: Mob077-05Concentrated 0.5ml Status:Regulatory IVD PDM056-10MMPrediluted 10ml PDM056Prediluted 6ml Catalog No.: Mob077Concentrated 1ml Clone: Chain Lambda Light Monoclonal MouseAnti-Human Cellular Positive Isotype: proteins covalently coupled to polyaminostyrene microbeads. Immunogen: Mob201-05Concentrated 0.5ml Status:Regulatory IVD PDM114-10MMPrediluted 10ml PDM114Prediluted 6ml Catalog No.: Mob201Concentrated 1ml Clone: Chain Lambda Light Monoclonal MouseAnti-Human of immunoglobulins in leukemias, plasmacytomas and some non-Hodgkin non-Hodgkin some and plasmacytomas leukemias, in immunoglobulins of the on found are surface of chains B cells in lymphoid tissues. light This antibody is Lambda useful for the identification isotypes. chain heavy bound and free Specificity: Specificity: Cellular ------N10/2 HP6054
Localization: Localization: IgG1, kappa IgG2a Control: Control: Tonsil This antibody does not show any cross-reactivity with kappa light kappa with cross-reactivity any show not does antibody This This antibody is specific to human lambda light chain. It reacts with reacts It chain. light lambda human to specific is This antibody BALB/C mice were immunized with purified IgG from human serum. ABC ie ee netd ih uiid ua IG myeloma IgG human purified with injected were mice BALB/C Tonsil Cytoplasm Cytoplasmic F F 360 360 ,/ ,/
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P ,/ ,/ 3 6 0 3 6 0 F BALB/C mice were immunized with human peripheral blood Human colon carcinoma cells. carcinoma colon Human Lewis Y is expressed in large bowel tumors and colorectal The human leukocyte common antigen is a family of five or more Hepatocellular Carcinoma, Colon Carcinoma Colon Carcinoma, Hepatocellular Control: Tonsil Control: IgG1, kappa IgG1, Both clones, IgG1, kappa IgG1, clones, Both Cell membrane, cytoplasmic and extracellular and cytoplasmic membrane, Cell Localization: Cell membrane Cell Localization: PD7/26 2B11 DBM15.43 ------Immunogen: Isotype: Positive Cellular Specificity: Monoclonal Mouse Anti-Human F Le is Monoclonal Mouse Anti-Human Mouse Anti-Human Monoclonal Antigen Common Leukocyte (LCA)/CD45 Immunogen: lymphocytes to raise clone PD7/26 and with T isolated neoplastic cell cells from 2B11. clone raise to lymphoma Isotype: Positive Cellular Specificity: high of molecular M Āglycoproteins weight and 220 kDa, present 180, 10, Ā205 on the surface of the majority of human leukocytes. This antibody labels Regulatory Status: IVD Regulatory Status: Clone: 1ml Mob517 Concentrated No.: Catalog 6ml PDM252 Prediluted 10ml PDM252-10MM Prediluted Clone: 1ml Mob040 Concentrated No.: Catalog 6ml Prediluted PDM00 10ml Prediluted PDM00 -10MM 0.5ml Mob040-05 Concentrated lymphoid cells. It labels neoplastic B and T cells in non-Hodgkin lymphoma and in and lymphoma non-Hodgkin in cells T and B neoplastic labels It cells. lymphoid types. cell T and B of leukemias Regulatory Status: IVD Regulatory Status: carcinomas. carcinomas. It may be useful in the classification of human renal and tumors. bladder The Lewis Y antigen has been evaluated as diagnosis and prognosis of a cholangiocarcinoma, hepatocellular carcinoma and clinical marker for the cancer. breast Formalin fixed paraffin embeddedFormalin human hepatocellular stainedcarcinoma with YLewis (Mob517). Formalin fixed Formalin paraffin embedded human tonsil stained with CommonLeukocyte Antigen (Mob040). 83 E E P
P ,/ ,/ F Lambda light chains isolated from pooled urine of patients with The A chain of human laminin. human of chain A The This antibody reacts with the terminal globular domain of the A This antibody reacts with free as well as bound lambda light chains. as well with free This antibody reacts F Skin Control: Tonsil Control: IgG2a, kappa IgG2a, Basement membrane Basement Localization: Cytoplasmic Localization: 4C7 ------RP027 Concentrated 1ml RP027 Concentrated No.: Catalog 6ml Prediluted PDR016 IVD Regulatory Status: 0.5ml Concentrated RP027-05 Lambda Light Chain Polyclonal Rabbit Anti-Human Polyclonal Monoclonal Mouse Anti-Human Immunogen: Isotype: Positive Cellular Specificity: and tissues paraffin of fixation to sensitive is antibody this with staining The chain. treatment. enzymatic proteolytic of use Laminin Immunogen: proteinuria. Jones Bence Positive Cellular Specificity: adsorption. phase solid by removed been have antibodies Contaminating Clone: 1ml Mob202 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob202-05 Concentrated Formalin fixed paraffin embedded renal carcinoma stained with Laminin antibody (Mob202). stained embedded renal carcinoma paraffin fixed Formalin Formalin fixed paraffin embeddedFormalin human tonsil stained with Lambda Light Chain antibody (RP027). Page 82-86 Hard Edit.pdf 2 Page 82-86 Hard Edit.pdf 3 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithMacrophageantibody (Mob203). neutrophils, monocytes, macrophages and squamous mucosal epithelia. as calprotectin, calgranulin and cystic fibrosis antigen. This antibody reacts with Specificity: Cellular Positive Isotype: membrane preparation. ABC ie ee netd ih fiiy uiid monocyte purified affinity with injected were mice BALB/C Immunogen: Formalin fixed paraffin embeddedhumantonsilstainedwithLysozyme antibody(RP028). not cross-react with any other cell types. monocytes and macrophages in human tonsil, skin and colon. This antibody does Regulatory Status:Regulatory I PDR005Prediluted 6ml RP028-05Concentrated 0.5ml Catalog No.: RP028Concentrated 1ml Mob203-05Concentrated 0.5ml Status:Regulatory Catalog No.: Mob203Concentrated 1ml Clone: Macrop age Monoclonal MouseAnti-Human granulocytes, stains It lysozyme. with reacts antibody This Specificity: Cellular Positive Immunogen: Lysozyme/Murami ase Polyclonal Anti-Human Rabbit ------MAC387 Localization: Cytoplasmic IgG1 Localization: Cytoplasmic Control: Tonsil Control: Tonsil This antibody is specific to human leukocyte antigen L1, also known Lysozyme isolated from urine of patients with monocytic leukemia. I
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84 Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithMVPantibody(Mob344). antibody (RMAB036). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithMammaglobin-A design the of forbreast approachcancer-specific immunotherapy. important an provide may responses immune cell mammaglobin-A- to T specific Thus, restricted tumors. is breast metastatic expression and of epithelium pattern mammary This tumors. breast primary and lines cancer- breast human overexpressedcell cancer breasthighly in is Mammaglobin-A genes.associated novel, of isolation the at directed approach screening Specificity: Cellular Positive Isotype: Mammaglobin A. Antibodies to progesterone and glucocorticoid receptors are also able to co- immunoprecipitate to the MVP. able also are receptors glucocorticoid and (LRP). progesterone to protein Antibodies related lung-resistance to identical Treatment of cells with estradiol is increases the amount of MVP in nuclear extract. It (MVP). protein vault Specificity: Cellular Positive Isotype: breast human cancer of MCF-7 cells. extract of flow-through column phosphocellulose the from Mob344-05Concentrated 0.5ml Status:Regulatory Catalog No.: Mob344Concentrated 1ml Clone: Immunogen: Ma or ault Protein M P /LRP Monoclonal MouseAnti-Human Immunogen: Immunogen: RMPD036Prediluted 6ml Status:Regulatory Catalog No.: RMAB036 Concentrated 1ml Clone: Mammaglo in-A Anti-Human Monoclonal Rabbit ------1032 EPR 0 2 Localization: Cytoplasmic Localization: Cytoplasmic Rabbit IgG IgG1 Control: Breast carcinoma Control: Breast h mmalbn ee a frt dniid sn a differential a using identified first was gene mammaglobin The This antibody reacts with a 104 to 110 kDa protein known as major as known protein kDa 110 to 104 a with reacts antibody This BALB/C mice were injected with proteins precipitated with AER317 rcmiat rti famn crepnig o human to corresponding fragment protein recombinant A I I
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P P 2/17/17 5:05PM Primary Antibodies 2/17/17 5:05 PM www.dbiosys.com P/H , H P ,/ F 3 6 0 F Cytoplasmic Melanoma BALB/C mice were injected with a purified human skin chymase. skin human purified a with injected were mice BALB/C BALB/C mice were injected with recombinant MART-1 protein. MART-1 recombinant with injected were mice BALB/C This antibody reacts with mast cells distributed in skin, synovium, This antibody is specific to a protein of 20 kDa known as MART-1 Tonsil Control: IgG1 Cytoplasmic Localization: Control: IgG1 localization:
CC1 A103 ------Immunogen: Isotype: Positive Cellular Specificity: and lung, heart. Mast cells contain a number of chemicals preformed mediators Human tryptase. proteolytic and carboxypeptidase, chymase, histamine, as such an is and cells mast of marker important an be to considered is chymase cell mast inflammation. of mediator important Clone: 1ml Mob346 Concentrated No.: Catalog 0.5ml Mob346-05 Concentrated 6ml PDM15 Prediluted IVD Regulatory Status: Monoclonal Mouse Anti-Human Chymase Mast Cell Monoclonal Mouse Anti-Human Monoclonal Marker Melanoma MART-1/Melan-A, Clone: 1ml Mob277 Concentrated No.: Catalog 6ml PDM153 Prediluted 10ml Prediluted PDM153-10MM IVD Regulatory Status: 0.5ml Mob277-05 Concentrated Immunogen: Isotype: Positive Cellular Specificity: (melanoma antigen recognized by T cells-1) or Melan-A. This antibody does not cross-react with MAGE-1or tyrosinase. MART-1 is a newly identified melanocyte differentiation differentiation antigen recognized by autologous cytotoxic T lymphocytes. This Formalin fixed Formalin paraffin embedded human tonsil stained with Mast Cell Chymase antibody (Mob346). Formalin fixed paraffin embedded human melanoma stained with MART-1/Melan-A antibody embedded human melanoma stained with MART-1/Melan-A paraffin fixed Formalin (Mob277). antibody stains melanomas and other tumors showing melanocytic differentiation. melanocytic showing tumors other and melanomas stains antibody 85 NEW H H P P
,/ ,/ 3 6 0 F rediluted 10ml rediluted oncentrated 1ml oncentrated 0.5ml rediluted 6ml rediluted AB0 2 C AB0 2-1 C A synthetic peptide corresponding to residues on the N-terminus A synthetic peptide corresponding to residues Recombinant human MLANA protein. MLANA human Recombinant RMPD0 2 P RMPD0 2-10RM P This antibody recognizes a protein doublet of 20-22kDa, identified as identified 20-22kDa, of doublet protein a recognizes antibody This This product is intended for qualitative immunohistochemistrywith qualitative for intended is product This F Melanoma Control: Skin, melanoma Skin, Control: Rabbit IgG Rabbit Rabbit IgG Rabbit Cytoplasmic Localization: Cytoplasmic Localization: DBR16.7 EP43 ------Immunogen: Isotype: Positive Cellular Specificity: MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous recognized antigens associated melanoma other Seven lymphocytes. T cytotoxic gp75, gp100, tyrosinase, MAGE-3, MAGE-1, include cells T cytotoxic autologous by Monoclonal Rabbit Anti-Human MART-1/Melan-A/MLANA Immunogen: of human MART-1 protein. MART-1 human of Isotype: Positive Cellular Specificity: normal and neoplastic paraffin-embeddedformalin-fixed, tissue sections, to be RM Clone: RM No.: Catalog IVD Regulatory Status: BAGE-1, BAGE-1, and GAGE-1. Subcellular fractionation shows that is MART-1 present in other and melanomas labels Mab This reticulum. endoplasmic and melanosomes for positive-marker useful a also is It differentiation. melanocytic showing tumors angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or origin. mesenchymal viewed viewed by Clinical light microscopy. interpretation of staining results should be accompanied by histological studies with histories and proper other relevant controls. diagnostic tests Patients’ should results. interpreting be clinical and utilized evaluating when by person(s) a qualified Monoclonal RabbitMonoclonal Anti-Human Clone: 0.5ml Concentrated RMAB044 No.: Catalog IVD Regulatory Status: 1ml Concentrated RMAB044-1 6ml RMPD044 Prediluted MART-1 Formalin fixed paraffin embedded human melanoma stained with MART-1/Melan-A/MLANA paraffin fixed Formalin (RMAB092). Formalin fixed paraffin embedded human melanoma stained with MART-1 Antibody (RMAB044). with MART-1 embedded human melanoma stained paraffin fixed Formalin Page 82-86 Hard Edit.pdf 4 Page 82-86 Hard Edit.pdf 5 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanmelanomastainedwithMelanomaantibody(Mob079). (Mob347). Tryptase Cell antibody Mast with stained tonsil human Formalinembedded paraffinfixed junctional junctional and blue nevus cells. Non-melanocytic cells are negative. side chainofaglycoconjugate present inimmature melanosomes. reacts with It Specificity: Cellular Localization: Cytoplasm Positive Isotype: metastases from lymph nodes. is tryptase cell mediator of inflammation. mast Human tryptase. considered to be an important marker of mast cell activation and proteolyticis an important and carboxypeptidase, Monoclonal MouseAnti-Human Regulatory Status:Regulatory I PDM011-10MMPrediluted 10ml PDM011Prediluted 6ml Mob07 -05C Catalog No.: Mob07 C Clone: Immunogen: Melanoma Monoclonal MouseAnti-Human contain a number of preformed chemicals mediators such as histamine, chymase, cells Mast type. cell other any with bind not does antibody heart. This and lung, Specificity: Cellular Positive Isotype: Immunogen: Status:Regulatory I PDM160Prediluted 6ml Mob347-05Concnentrated 0.5ml Catalog No.: Mob347Concentrated 1ml Clone: Mast Cell Tryptase ------HMB45 AA1 Localization: Cytoplasmic IgG1, kappa IgG1 Control: Melanoma Control: Tonsil This antibody reacts with a neuraminidase sensitive oligosaccharide This antibody reacts with mast cells distributed in skin, synovium, skin, in distributed cells mast with reacts antibody This BALB/C mice were injected with extract of pigmented melanoma BALB/C mice were injected with a purified human lung tryptase. oncentrated 1ml oncentrated 0.5ml 360 / / P P 86 Formalin fixed paraffin embeddedhumanmelanomastainedwithMelanomaantibody(Mob421). Formalin fixed paraffin embeddedhumanmelanomastainedwithMelanomacocktail (PDM146). cocktail cocktail a first-order pan melanoma screener. HMB45. HMB45. MART-1 HMB45, antibody The combination of triple this make tyrosinase and has been shown to label a higher percentage of desmoplastic melanomas than than melanomas desmoplastic of percentage higher a label to shown been has tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It It MART-1. and HMB45 to compared when marker sensitive more a be to tyrosinase enzyme involved in the initial stages of melanin biosynthesis. Studies have shown shown have Studies biosynthesis. melanin of stages initial the in involved enzyme sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key key a is Tyrosinase melanomas. metastatic labeling when HMB45 than sensitive specific for melanocytic lesions. Studies have also shown that MART-1 is more more is MART-1 that shown also have Studies lesions. melanocytic for specific r Melan-A. or a protein of 20 kDa, identified as MART-1 (melanoma antigen recognized by T cells-1) cells-1) by recognized T antigen MART-1 (melanoma as identified kDa, 20 of protein a antibody has been shown to label the majority of melanomas. recognizes of A103 Clone shown majority been to the antibody has label pigment pigment epithelium and melanoma cells and is thought to be oncofetal in nature. This reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal retinal infantile and prenatal melanocytes, cutaneous in present is antigen reactive ie hi o a lccnuae rsn i imtr mlnsms Te HMB45- The melanosomes. immature in present glycoconjugate a of chain side Specificity: Cellular Positive Isotype: Recombinant Recombinant human MART-1 protein (A103). Recombinant tyrosinase protein T311. with the non-melanocytic peptide antigen react used not fordoes PNL2, it immunization. as origin autoimmune Anti-Melanoma, of antibody melanocyte sarcomas.a be to seems cell clear and melanomas of identification Specificity: Cellular Positive Isotype: Immunogen: PDM213-10MMPrediluted 10ml PDM213Prediluted 6ml Mob421-05Concentrated 0.5ml Status:Regulatory I Catalog No.: Mob421Concentrated 1ml Clone: Melanoma Monoclonal MouseAnti-Human Immunogen: Mob428-05Concentrated 0.5ml PDM146-10MMPrediluted 10ml PDM146Prediluted 6ml Catalog No.: Mob428Concentrated 1ml Clone: Melanoma Coc tail Monoclonal MouseAnti-Human Regulatory Status:Regulatory I ------PNL2 HMB45 A103T311
Localization: HMB45 IgG1 and A103, T311, IgG2a Control: Localization: Cytoplasmic, membrane IgG1 Control: Melanoma The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide oligosaccharide neuraminidase-sensitive a with reacts clone HMB45 The
hs nioy aes eaoye ad s ueu to fr the for tool useful a is and melanocytes labels antibody This Melan-A is a useful addition to melanoma panels as it is apparently apparently is it as panels melanoma to addition useful a is Melan-A Pigmented melanoma metastases from lymph nodes (HMB45). Synthetic peptide. Metastatic melanoma in lymph node Cytoplasmic 3 60 3 60 / P
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www.dbiosys.com ( 0- 5kDa). P , F P , 3 6 0 3 6 0 transcription factor implicated in -HLH- IP) antibody recognizes human and mouse MLH1 mouse and human recognizes antibody Nuclear Nuclear Tonsil, colon carcinoma colon Tonsil, Melanoma G16 -15 Full length recombinant MLH. recombinant length Full BALB/Cmiceinjectedwerewith N-terminalfragment of human Mi protein. The Thisantibody reacts with a 52-56 kDa protein known as microphthalmia (Mi). Control: IgG1 Localization:
Control:
IgG1 Localization:
G16 -15 D5 ------Cellular Specificity: Monoclonal Mouse Anti-Human L F Clone: 1ml Mob430 Concentrated No.: Catalog 10ml PDM14 -10MM Prediluted I egulatory Status: 0.5ml Mob430-05 Concentrated 6ml PDM14 Prediluted Immunogen: Isotype: Positive Monoclonal Mouse Anti-Human Monoclonal ( I F) Factor ranscription icrophthalmia Immunogen: Clone: 1ml Mob462 Concentrated No.: Catalog 6ml Prediluted PDM16 10ml Prediluted PDM16 -10MM I egulatory Status: 0.5ml Mob462-05 Concentrated The repair of mismatch DNA is essential to maintaining the integrity of genetic Isotype: information over time. An alteration of microsatellite repeats is the result of slippage of result the is repeats microsatellite of alteration An time. over information Positive owing to strand misalignment during DNA replication and is referred to as Cellular microsatellite instability (MSI). These defects in DNA repair pathways have been Specificity: related related to human carcinogenesis. The importance of mismatch repair genes This antibody reacts with both melanocytic and non-melanocytic isoforms of Mi. Mi is a became apparent with the identification of the genetic basis for hereditary basic helix-loop-helix-leucine zipper (b nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of pigmentation, mast cells and bone development. There are two known isoforms of Mi mismatchnucleotides during Itthe mismatchrepairreplicationprocess. is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer ofaDNAitheterodimerduplexafteris joined thatbyaMSH2mismatchedbindsto differingby66amino acids atthe amino terminus. MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. mismatch in steps later the facilitate help together which PMSH, and MLH1 Formalin fixed Formalin paraffin embedded human colon carcinoma stained with MLH-1 antibody (Mob430). Formalin fixed paraffin embedded human skin stained with MiTF antibody (Mob462). paraffin fixed Formalin 7 P
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oncentrated 1ml Cell membrane Cell I F Mesothelioma Recombinant human MGMT protein. MGMT human Recombinant BALB/C mice were injected with suspension of human mesothelioma human of suspension with injected were mice BALB/C Mob34 -05 C O(6)-methylguanine-DNA-methyltransferase (MGMT) is a 22 kDa This antibody reacts with an unknown antigen on microvilli of F IgG1 Nuclear and cytoplasmic and Nuclear Localization: Control: IgM Localization:
MT3.1 HBME-1 ------Immunogen: Isotype: Tonsil Control: Positive Cellular Specificity: MGMT adducts. DNA O(6)-alkylguanine removes that protein repair DNA human and groups alkyl accepting by DNA the repairing protein acceptor suicide a as acts lymphocytes zone mantle all stains antibody This itself. inactivating consequently and 50% of antibody. this with germinal positive stained also center are mucosa lymphocytes. squamous Basaloid epithelial cells of tonsil Monolonal Mouse Anti-Human O( ) ethylguanine N ethyltransferase ( ) Immunogen: Monolonal Mouse Anti-Human Monolonal esothelioma Clone: 1ml Mob423 Concentrated No.: Catalog I egulatory Status: 0.5ml Mob423-05 Concentrated 6ml Prediluted PDM134 10ml Prediluted PDM134-10MM egulatory Status: Clone: Mob34 C No.: Catalog cells from patients with malignant epithelial mesothelioma. epithelial malignant with patients from cells Isotype: Positive Cellular Specificity: mesothelioma cells. It stains normal mesothelial cells as well as epithelial mesotheliomas in a thick membrane pattern due to abundant lung microvilli on the on microvilli lung abundant to due pattern membrane thick a in mesotheliomas surface of these cells. these of surface Formalin fixed paraffin embedded human tonsil stained with MGMT antibody (Mob423). paraffin fixed Formalin Formalin fixed paraffin embedded human mesothelioma stained with Mesothelioma antibody embedded human mesothelioma paraffin fixed Formalin (Mob349). Page 87-91 Hard Edit.pdf 1 Page 87-91 Hard Edit.pdf 2 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithMSH2antibody(Mob332). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithMMP-9 antibody(RP066). carcinogenesis. a b rsosbe o te utpe uain rqie fr multistage for required mutations multiple the for responsible be may turn in which replicationerrors,accumulation of the to leads function MSH2 of mismatched nucleotides during the post replication mismatch repair process. Loss (mismatchrepair protein 2). MSH2 proteininvolved is the initial in recognition of Specificity: Specificity: Cellular egulatory Status: egulatory I Positive Isotype: RP066-05Concentrated 0.5ml Status: egulatory Catalog No.: RP066Concentrated 1ml P Polyclonal Anti-Human Rabbit PDM17 -10MMPrediluted 10ml PDM17 Prediluted 6ml Mob332-05Concentrated 0.5ml Catalog No.: Mob332Concentrated 1ml Clone: Immunogen: S ( ismatch epairProtein) Monoclonal MouseAnti-Human Specificity: Cellular Positive Immunogen: components. MMPs play a crucial role in tumor cell invasion and metastasis. MMP ------ . 25D12
MMPs are proteolytic enzymes capable of degrading connective tissue connective degrading of capable enzymes proteolytic are MMPs Localization: IgG1, kappa Localization: Cytoplasmic Control Control: This antibody reacts with a hs nioy ecs ih 12 D poen nw a MSH2 as known protein kDa 102 a with reacts antibody This BALB/C mice were injected with recombinant human MSH2 protein. A synthetic peptide from the middle region of human MMP- . : Tonsil Breast carcinoma I Nuclear (Only for markets outsidetheU.S. For U.S. market, seeindex III.) F 2 kDa pro form and F 360 ,
P , P 6 kDa active form of .. Formalin fixed paraffin embeddedhuman colon carcinoma stainedwithMSH6antibody(PDM147). Formalin fixed paraffin embeddedhumanstomachstainedwithMucin5AC antibody(Mob357). the the hidden M1 antigen. mucin mucin in the adult colon or changes in the glycosylation pattern of mucin, which expose colonic colonic carcinogenesis is suggestive of either of re-expression the peptide core of gastric precancerous colon but not in normal colon. Resurgence of gastric mucin during during mucin gastric of Resurgence colon. normal in not but colon precancerous mucus cells of surface gastric epithelium and in goblet cells of the fetal and and fetal the of cells goblet in and epithelium gastric surface of cells mucus carbohydrates and 20% core protein. Gastric mucin M1 antigen is found in columnar columnar in found is antigen M1 mucin Gastric protein. core 20% and carbohydrates core of gastric mucin M1. Mucins are high molecular weight glycoproteins with with glycoproteins weight molecular high are Mucins M1. mucin gastric of core Specificity: Cellular Localization: Positive Isotype: genetic information over time. carcinoma. The colorectal repair sporadic of mismatch of DNA development is the essential to to maintaining contribute the genes integrity of MSH6 and MSH2 MLH-1, of mutations the shown have Studies humancarcinogenesis. to related as microsatellite instability (MSI). These defects in DNA repair pathways have been slippage owing to strand of misalignment during resultDNA replication and the is referred is to repeats microsatellite of alteration An loop. deletion insertion/ an an ovarian mucinous cyst belonging to an O Le (a-b) patient. egulatory Status: egulatory I PDM163Prediluted 6ml Mob357-05Concentrated 0.5ml Catalog No.: Mob357Concentrated 1ml Clone: imths Te S2MH cmlx eonzs snl-ae mispair single-base a recognizes complex MSH2-MSH6 The mismatches. Specificity: Cellular Positive Isotype: Immunogen: S Monoclonal MouseAnti-Human Immunogen: ucin C astric ucinF egulatory Status: egulatory I PDM147-10Prediluted 10ml PDM147Prediluted 6ml Catalog No.: Mob42 C Clone: Monoclonal MouseAnti-Human ------45M1 44
IgG1, kappa Control: F Localization: Nuclear IgG1 Control: Tonsil, colon carcinoma This antibody reacts with a 1000 kDa protein and recognizes the peptide peptide the recognizes and protein kDa 1000 a with reacts antibody This MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T Mob42 -05C BALB/C mice were injected with M1 mucin preparation from the fluid of of fluid the from preparation mucin M1 with injected were mice BALB/C Human MSH6. Stomach Cytoplasmic, cell surface oncentrated 1ml oncentrated 0.5ml 360 , , P
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2/17/17 5:06PM Primary Antibodies 2/17/17 5:06 PM www.dbiosys.com P P
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rediluted 6ml rediluted Cytoplasmic IVD IVD Tonsil Nuclei from pokeweed mitogen stimulated human peripheral Human myelin basic protein isolated from normal human brain. human normal from isolated protein basic myelin Human This antibody reacts with an antigen present in the cytoplasm of Brain Control: IgG1 Cytoplasmic Localization: BM2 ------Monoclonal Mouse Anti-Human (BM2) Marker Myeloid Clone: PDM0 4 P No.: Catalog Regulatory Status: Immunogen: lymphocytes. Isotype: Control: Positive Cellular Specificity: mature human granulocytes. It reacts with the and leukemias precursor myeloid and detect to mature used forms be can of antibody This cells. myeloid human differentiation. cellular of levels different as well as sarcomas granulocytic Polyclonal Rabbit Anti-Human Polyclonal (MBP) Basic Protein Myelin Immunogen: Positive Localization: Cellular Specificity: This antibody reacts with human myelin basic protein and RP052 Concentrated 1ml RP052 Concentrated No.: Catalog Regulatory Status: 0.5ml Concentrated RP052-05 oligodendrocytes of white matter in brain and also. nervesspinal peripheral cord. stains Grey antibody matter This stains weakly. Formalin fixed paraffin embedded tonsil stained with Myeloid Marker (PDM084). embedded tonsil stained with Myeloid Marker paraffin fixed Formalin Formalin fixed paraffin brain medula stained with Myelin Basic Protein antibody (RP052). medula stained with Myelin Basic Protein brain paraffin fixed Formalin .. NEW H P/H , P
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oncentrated 1ml IVD F Recombinant human MUC6 protein. MUC6 human Recombinant Recombinant GST-MUM1 protein. GST-MUM1 Recombinant The MUC6 gastric mucin is a secreted glycoprotein that plays an Multiple myeloma oncogene-1 (MUM1) is a 50kDa protein encoded oncogene-1 (MUM1) is a 50kDa protein Multiple myeloma Gastric cancer, stomach cancer, Gastric Control: IgG1, kappa IgG1, Cytoplasmic & Secreted & Cytoplasmic Localization: IgG1 Nuclear and cytoplasmic and Nuclear Localization: DBM15.21 MUM1P ------Monoclonal Mouse Anti-Human MUM1 Protein Immunogen: Isotype: Positive Cellular PDM210 Prediluted 6ml PDM210 Prediluted 10ml PDM210-10MM Prediluted IVD Regulatory Status: Specificity: essential role in epithelial cyto-protection microorganisms, from and mechanical acid, trauma in the proteases, gastrointestinal tract. pathogenic Mucin 6 expression is highest in the stomach and gall with bladder, lower expression in the terminal ileum is 6 and Mucin 2; type right Lewis with colon. associated is In 6 Mucin gastric stomach, normal In cancer, expression. Mucin 6 has an altered also expressed in gastric metaplasia, and bladder, duodenum gall human of folds mucosal deeper the and in located mucin, secretory pancreas. Mucin 6 inflammation. of is degrees increasing a with altered is expression its Clone: Mob4 3 C No.: Catalog Monoclonal Mouse Anti-Human Monoclonal 6/GastricMUC6 (Mucin Mucin) Clone: 1ml Mob420 Concentrated No.: Catalog Regulatory Status: 0.5ml Mob420-05 Concentrated Formalin fixed paraffin embedded human stomach stained with MUC6 (Mob493). paraffin fixed Formalin Immunogen: Isotype: Tonsil Control: Positive Cellular Specificity: by the This MUM1 antibody gene. stains MUM1 protein, which is expressed in a T activated cells, plasma center, germinal the of zone light the in cells B of subset antibody This neoplasms. hematolymphoid related spectrumof wide a and cells malignancies. lymphoid of classification sub the in useful is Formalin fixed paraffin embedded human tonsil stained with MUM1 Protein antibody (Mob420). embedded human tonsil stained with MUM1 Protein paraffin fixed Formalin Page 87-91 Hard Edit.pdf 3 Page 87-91 Hard Edit.pdf 4 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embedded human tonsil stained with Myeloperoxidase antibody (Mob206-1). antibody Myeloperoxidase with stained tonsil human Formalinembedded paraffinfixed (RP053). antibody Myeloperoxidase with Lymphoma stained B-Cell embedded paraffin Formalinfixed RP053-05Concentrated 0.5ml Status: egulatory I PDR04 Prediluted 6ml Catalog No.: RP053Concentrated 1ml yeloperoxidase Polyclonal Anti-Human Rabbit localized to chromosome 17. egulatory Status: egulatory I myeloid cells of acute myeloid leukemia. The myeloperoxidase gene has been has gene myeloperoxidase in The leukemia. myeloid found acute of myeloperoxidase cells myeloid detects the antibody with The cells. strongly myeloid stains of antibody cytoplasm This phagocytes. activated by generated Mob206-1-05Concentrated 0.5ml PDM10 -1-10MMPrediluted 10ml PDM10 -1Prediluted 6ml Catalog No.: Mob206-1Concentrated 1ml Clone: ylprxds mtblzs ot f h hdoe peroxide hydrogen the of most metabolizes Myeloperoxidase Specificity: Cellular Positive Isotype: Immunogen: yeloperoxidase Monoclonal MouseAnti-Human of neutrophils, granulocytes in spleen, bone marrow, tonsil and blood smears. Specificity: Cellular Positive Immunogen: ------5 A5 Localization: Cytoplasmic Localization: Cytoplasmic Control: Tonsil Control: Tonsil IgG2b, kappa This antibody reacts with human myeloperoxidase. It stains granules Recombinant protein from exon 7 of the human myeloperoxidase. Myeloperoxidase isolated from human granulocytes. F F 360 ,
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P 0 adult adult tissue but is expressed strongly in the tumor cell nuclei of rhabdomyosarcomas. Formalin fixed paraffin embeddedrhabdomyosarcoma stainedwithMyoD1antibody(Mob278). Formalin fixed paraffin embedded human rhabdomyoscarcoma stained with Myogenin (PDM158). Myogenin with rhabdomyoscarcoma stained human embedded paraffin Formalinfixed nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal normal in detected not is MyoD1 tissues. muscle developing in myoblasts of nuclei MyoD1. MyoD1. This antibody does not react with myogenin, Myf5 or Myf6. MyoD1 stains the This This antibody is specific to epitope an of amino acid 3-56 in the N-terminus mouse of Specificity: Cellular Positive Isotype: Immunogen: Immunogen: egulatory Status: egulatory I PDM120Prediluted 6ml Catalog No.: Mob27 C Clone: yo Monoclonal MouseAnti-Human egulatory Status: egulatory I PDM15 -10MMPrediluted 10ml PDM15 Prediluted 6ml Mob322-05Concentrated 0.5ml Catalog No.: Mob322Concentrated 1ml Clone: yogenin Monoclonal MouseAnti-Human cells of skeletal muscle to origin. restricted is myogenin of Expression development. muscle for essential are which factors transcription of set a encode MRF4. genes MyoD,These and myf5 includes which genes regulatory myogenic of family of member a is Myogenin Specificity: Cellular Positive Isotype: rat myogenin amino acid 30-224. Immunogen: ------5.2F F5D
Localization: IgG2a Control: Localization: Nuclear IgG1 Control: Rhabdomyosarcoma F This antibody is specific to a 45 kDa protein, which is identified as MyoD1. Ti atbd i seii t 3 ka rti kon s myogenin. as known protein kDa 34 to specific is antibody This Mob27 -05C BALB/C BALB/C mice were injected with a recombinant mouse MyoD1 protein. BALB/C mice were injected with recombinant protein containing protein recombinant with injected were mice BALB/C Rhabdomyosarcoma Nuclear oncentrated 1ml oncentrated 0.5ml F 360 , ,
P P 2/17/17 5:06PM Primary Antibodies 2/17/17 5:06 PM www.dbiosys.com H P P
,/ , 3 6 0 F oncentrated 0.5ml oncentrated 1ml F Pancreas BALB/C mice were injected with γ-γ enolase from human brain. human from enolase γ-γ with injected were mice BALB/C BALB/C mice were injected with purified neurofilaments from This antibody is specific to γ-γ enolase isozyme of 46 kDa. This : Brain : Control IgG1 IgG1, kappa IgG1, Cytoplasmic Localization: Cytoplasmic Localization: I-H14 2F11 ------Monoclonal Mouse Anti-Human Neuron Specific Enolase (NSE) Neuron Immunogen: Isotype: Control: Positive Cellular Specificity: oat cell carcinomas, gangliomas, cells, neuroendocrine antibody stains neurons, astrocytomas, paragangliomas, glioblastomas, pheochromocytomas, Monoclonal Mouse Anti-Human Monoclonal Neurofilaments Immunogen: brain. human Isotype: Positive Cellular Specificity: This antibody reacts with 70 and 200 kDa component of the Clone: 1ml Mob212 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob212-05 Concentrated Clone: Mob0 0 C No.: Catalog Mob0 0-05 C 6ml Prediluted PDM012 10ml Prediluted PDM012-10MM IVD Regulatory Status: melanomas and schwannomas. and melanomas neurofilament neurofilament polypeptide subunit. It stains neurons, neuronal processes and peripheral nerves. This antibody reacts with some neuroblastomas and gangliomas but not with other nonneuronal tumors. nonneuronal other with not but gangliomas Formalin fixed paraffin embedded human pancreas stained with NSE antibody (Mob212). paraffin fixed Formalin Formalin fixed paraffin embedded human brain stained with Neurofilaments antibody (PDM012). embedded human brain paraffin fixed Formalin 1 P P , , F F 3 6 0 BALB/C mice were injected with synthetic peptide from N terminus N from peptide synthetic with injected were mice BALB/C Rabbit muscle myosin. muscle Rabbit This antibody recognizes heavy chain of human skeletal myosin. It IgG1 Skeletal muscle Skeletal Control: Lung adenocarcinoma Lung Control: IgG1 Cytoplasmic Localization: . CG1.1 M 32 ------Immunogen: Napsin A Monoclonal Mouse Anti-Human Immunogen: Isotype: Positive Cellular Specificity: Monoclonal Mouse Anti-Human Monoclonal (Fast) Skeletal Myosin, Clone: 1ml Mob463 Concentrated No.: Catalog 0.5ml Mob463-05 Concentrated 6ml PDM154 Prediluted IVD Regulatory Status: IVD Regulatory Status: Clone: 1ml Mob207 Concentrated No.: Catalog 0.5ml Mob207-05 Concentrated 6ml rediluted PDM0 5 P 10ml Prediluted PDM0 5-10MM of human napsin A. napsin human of Isotype: Positive Cellular Localization: Napsin is is and kDa found 35.0 of in weight molecular two a has A isoforms, Napsin sequences. A gene homologous and B, with highly in the which is expressed Napsin A is an aspartic proteinase TA02. also known as in expressed also is It (SP-B). B surfactantprotein processing in involved and lung lung primary for marker tumor a as tool useful a be may antibody This kidney. the adenocarcinoma. Napsin expression correlates with the grade differentiation of adenocarcinoma. lung does not stain cardiac or smooth muscle myosin. This antibody stains molecule. the isomyosin fast II) (type twitch Formalin fixed paraffin embedded lung adenocarcinoma stained with Napsin A (PDM154). embedded lung adenocarcinoma paraffin fixed Formalin Formalin fixed paraffin embedded human skeletal muscle stained with Myosin antibody (Mob207). muscle stained with embedded human skeletal paraffin fixed Formalin Page 87-91 Hard Edit.pdf 5 Page 92-96 Hard Edit.pdf 1 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanEwing'ssarcoma stainedwithNKX2.2(RMAB085). Formalin fixed paraffin embeddedhumanpancreasstainedwithNSEantibody(RP054). small round cell tumors. xrsin nlss I at a a aube akr o Eig acm, ih a with sarcoma, Ewing for marker valuable sensitivity of a 3% Āand a as specificity of 8%, Āand acts aids in the differential It diagnosis of analysis. expression gene array-based of basis the on sarcoma Ewing in upregulated differentially of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target No staining with other tissue types has been seen. the brain, in islets of Langerhans in pancreas and in peripheral nerves of the skin. enolase containing γ subunits. This antibody gives a specific staining in neurons of RP054-05Concentrated 0.5ml Status:Regulatory PDR006-10RPPrediluted 10ml PDR006Prediluted 6ml Catalog No.: RP054Concentrated 1ml RMPD085Prediluted 6ml RMAB085-1 Concentrated 1ml Status:Regulatory IVD RMPD085-10RMPrediluted 10ml Catalog No.: RMAB085 Concentrated 0.5ml Clone: h gt mkn i a oeta mre fr h suy f gastrointestinal of study the for marker potential a it making gut, the Specificity: Cellular Positive Isotype: Immunogen: NKX2.2 Anti-Human Monolonal Rabbit Specificity: Cellular Positive Control: Immunogen: Neuron SpecificEnolase, Bovine (NSE) Polyclonal Anti-Human Rabbit ------DBR16.3
Localization: Localization: Nuclear IgG Control: Pancreas, Ewing's sarcoma F hs nioy ecs ih ua ionye o nuo specific neuron of isoenzymes human with reacts antibody This Expression of NKX2.2 has been found in neuroendocrine tumors of tumors neuroendocrine in found been has NKX2.2 of Expression Neuron specific enolase (γ-γ isoenzyme) isolated from bovine brain. Recombinant human NKX2.2 protein fragment. Pancreas IVD Cytoplasmic
360 3 60 ,/ F
P H , P NEW 2 Formalin fixed paraffin embeddedhumanEwing'ssarcoma stainedwithNKX2.2(Mob486). Formalin fixed paraffin embeddedhumanpancreasestainedwithNSEgamma(Mob499). and and tumors of neuroendocrine origins, such as pheochromocytomas. the glycolytic pathway. NSE-gamma is a useful marker to identify peripheral nerves nerves peripheral identify to marker useful a is NSE-gamma pathway. glycolytic the and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in in acid phosphenolpyruvic to acid phosphoglyceric converting in role a play they and only in nervous tissue. These isoforms exist as both homodimers and heterodimers, heterodimers, and homodimers both as exist isoforms These tissue. nervous in only form is expressed predominantly in muscle tissue whereas gamma-enolase is found found is gamma-enolase whereas tissue muscle in predominantly expressed is form cell type specific markers. Alpha-isoform is expressed in most tissues, whereas beta- whereas tissues, most in expressed is Alpha-isoform markers. specific type cell different cell type specific expression patterns, so that antibodies to them are useful useful are them to antibodies that so patterns, expression specific type cell different and ENO3 or alternately as enolase alpha, beta and gamma. The three enolases have have enolases three The gamma. and beta alpha, enolase as alternately or ENO3 and enolase. It is one of three mammalian enolases, which are also known as ENO1, ENO2, ENO2, ENO1, as known also are which enolases, mammalian three of one is It enolase. differential diagnosis of small round cell tumors. expression analysis.gene It acts array-based as a valuable of marker for basis Ewing sarcoma the and aids in on the sarcoma Ewing in upregulated differentially of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target Specificity: Cellular Positive Isotype: Status:Regulatory IVD h gt mkn i a oeta mre fr h suy f gastrointestinal of study the for marker potential a it making gut, the Specificity: Cellular Positive Isotype: Immunogen: PDM1 Prediluted 6ml Status:Regulatory IVD PDM1 -10MMPrediluted 10ml Catalog No.: Mob486Concentrated 1ml Clone: NKX2.2 Monoclonal MouseAnti-Human Immunogen: Immunogen: PDM227Prediluted 6ml PDM227-10MMPrediluted 10ml Catalog No.: Mob4 C Clone: NSE gammaF Monoclonal MouseAnti-Human ------DBM15.15 DBM15.25
Localization: IgG Control: Localization: Nuclear IgG2b, kappa Control: Ewing's sarcoma F eonzs poen f bu 5ka wih s dniid s gamma- as identified is which 50kDa, about of protein a Recognizes Expression of NKX2.2 has been found in neuroendocrine tumors of tumors neuroendocrine in found been has NKX2.2 of Expression A A synthetic peptide corresponding to aa416-433 of human NSE gamma. Human full-length recombinant NKX2.2 protein. Pancreas, Brain Cytoplasmic oncentrated 1ml 3 60 3 60 ,/ ,/ P
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,/ BALB/C mice were injected with mouse recombinant p27 protein. p27 recombinant mouse with injected were mice BALB/C BALB/C mice were injected with a full length human recombinant human length full a with injected were mice BALB/C This antibody is specific to a protein of 27 kDa known as p27Kip1 a cell a p27Kip1 as known kDa 27 of protein a to specific is antibody This F Colon carcinoma Colon Control: Colon carcinoma Colon Control: IgG1 IgG2a Nuclear Localization: DCS-72.F6 DCS-60.2 ------p27Kip1 Immunogen: Isotype: Positive Cellular Specificity: This an antibody epitope recognizes between cycle regulatory mitotic inhibitor. with cross-reactivity any show not does antibody This p27. of 83-204 acids amino inhibitors. mitotic related other p21WAF1/Cip1/Sdi1/Pic1 Mitotic Inhibitorp21WAF1/Cip1/Sdi1/Pic1 Immunogen: protein. p21 Isotype: Positive Nuclear Localization: Cellular Specificity: This antibody recognizes a 21 kDa protein identified as Clone: 1ml Mob281 Concentrated No.: Catalog 0.5ml Mob281-05 Concentrated IVD Regulatory Status: Monoclonal Mouse Anti-Human Mouse Anti-Human Monoclonal Clone: 1ml Mob280 Concentrated No.: Catalog IVD Regulatory Status: 0.5ml Mob280-05 Concentrated Monoclonal Mouse Anti-Human p21WAF1/Cip1/Sdi1/ p21WAF1/Cip1/Sdi1/ Pic1 tumor suppressor inhibitors. mitotic other protein. to cross-reactivity any show This not does and p21 to specific antibody is highly This antibody does not cross-react with mouse and rat. and mouse with cross-react not does antibody This Formalin Formalin fixed paraffin embedded human colon carcinoma stained with p27Kip1 antibody (Mob281). Formalin fixed paraffin embedded human breast carcinoma stained with p21WAF1 antibody stained with p21WAF1 embedded human breast carcinoma paraffin fixed Formalin (Mob280). 3
H H P P
,/ ,/ 3 6 0 Nuclear Nuclear Seminoma Seminoma BALB/C mice injected with synthetic peptide of human OCT-4 origin. OCT-4 human of peptide synthetic with injected mice BALB/C F A synthetic peptide corresponding to residues of human OCT-4 protein. OCT-4 humanof residues to corresponding peptidesynthetic A OCT-4 (also known as POU5F1) is a transcription factor that has been OCT-4 (octamer-bindingtranscriptionOCT-4factor 4)also known as POU5F1 is a Control: IgG2b F Localization: Control:
Rabbit IgG Rabbit Localization:
NRG1.1 EP143 ------IImmunogen: Monoclonal Mouse Anti-Human OCT-4 Immunogen: Clone: 1ml Mob464 Concentrated No.: Catalog 0.5ml Mob464-05 Concentrated 6ml PDM155 Prediluted 10ml PDM155-10MM Prediluted IVD Regulatory Status: Monoclonal RabbitMonoclonal Anti-Human OCT-4 Clone: 0.5ml Concentrated RMAB075 No.: Catalog IVD Regulatory Status: 6ml RMPD075 Prediluted Isotype: Positive Cellular Isotype: Positive Cellular Specificity: Specificity: homeodomain transcription factor. It is involved in self-renewal of undifferentiated recognized as fundamental in the maintenance of pluripotencyofembryonicin stem maintenance the infundamental as recognized embryonicItstemcells. is usedfrequentlyasOCT-4 cells.a marker undifferentiated for cells and primordial germ cells. It has been proposed as a useful marker for germ cell germ for marker useful a as proposed been has It cells. germ primordial and cells expression must be closely regulated; too much or too little will cause differentiation of differentiation causewill little too or much too regulated; closelybe must expression tumors (GCT) that exhibit features of pluripotentiality (seminoma/dysgerminoma, germinoma and embryonal carcinoma. OCT-4 immunostaining has been shown to shown beenhas immunostaining OCT-4 embryonalcarcinoma.and germinoma the cells. OCT-4 is one of the transcription factors used to create induced pluripotent be sensitive and specific for GCT, whether in primaryinwhether extragonadal orsitesgonadal GCT, for specificand sensitive be stemiscells.OCT-4 sensitiveand specific marker forgerm cell tumors like seminomas, gonadoblastoma, germinoma and embryonal carcinomas but not for differentiated or in metastatic lesions. metastatic in or cells of nonseminomas, i.e. teratomas, yolk sac tumors and choriocarcinomas. OCT-4 can detect both primary and metastatic germ cell tumors. cellgerm metastatic primaryand bothdetect can Formalin fixed paraffin embedded testis stained with OCT-4 antibody (Mob464). embedded testis stained with OCT-4 paraffin fixed Formalin Formalin Formalin fixed paraffin embedded human testis stained antibodywith OCT-4 (RMPD075). Page 92-96 Hard Edit.pdf 2 Polyclonal Rabbit Anti-Human Monoclonal Rabbit Anti-Human p P p P Catalog No : RP163-05 Concentrated 0.5ml Clone: EP PDR055 Prediluted 6ml Catalog No : RMAB067 Concentrated 0.5ml PDR055-10RP Prediluted 10ml 3 6 0 RMPD067 Prediluted 6ml
egulatory Status: I egulatory Status: I
Formalin fixed paraffin embedded human lung squamous cell carcinoma stained with p40 antibody Formalin fixed paraffin embedded colon carcinoma stained with p53 antibody (RMAB067). (PDR055). Immunogen: A synthetic peptide corresponding to N-terminal residues of Immunogen: A synthetic peptide corresponding to amino acids 5-17 of human p40. human p53 protein. Positive Control: Prostate Isotype: Rabbit IgG Cellular Localization: Nuclear Positive Control: Colon Cancer Specificity: p40 is a relatively unknown antibody that recognizes Np63-a p63 Cellular Localization: Nuclear isoform suggested to be highly specific for squamous/basal cells. In a recent study, Specificity: p53 acts as both a tumor-suppressor and transcription factor that, p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly upon activation by DNA damage and other cellular stress signals, leads to the superior to p63 in specificity1, which eliminates a potential pitfall of misinterpreting transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair. p53 a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell is overexpressed in over 50% of human cancers. Positive staining of p53 detected carcinoma. These findings strongly support the routine use of p40 in place of p63 for by immunohistochemistry has been observed in colon cancer, breast cancer, lung the diagnosis of pulmonary squamous cell carcinoma. cancer, prostate cancer and ovary cancer. ------
Monoclonal Rabbit Anti-Human Monoclonal Mouse Anti-Human p P p P
Primary Antibodies Clone: SP5 Clone: Bp53-12 Catalog No : RMAB016 Concentrated 0.5ml Catalog No : Mob217 Concentrated 1ml RMPD016 Prediluted 6ml Mob217-05 Concentrated 0.5ml RMPD016-10RM Prediluted 10ml 3 6 0 PDM035 Prediluted 6ml PDM035-10MM Prediluted 10ml 3 6 0 egulatory Status: I egulatory Status: I
Formalin fixed paraffin embedded colon carcinoma stained with p53 antibody (RMAB016). Immunogen: Recombinant human full-length wild type p53 protein. Formalin fixed paraffin embedded colon carcinoma stained with p53 antibody (Mob217). Isotype: IgG Immunogen: Recombinant wild type p53 protein. Positive Control: Colon carcinoma Isotype: IgG2a Cellular Localization: Nuclear Positive Control: Breast carcinoma Specificity: This antibody recognizes p53 protein. p53 is a tumor suppressor gene Cellular Localization: Nuclear expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, S40 ĀT antigen and human Specificity: This antibody is specific to human p53 protein, both wild and mutant papilloma virus E6 protein. p53 senses DNA damage and possibly facilitates forms under denaturing and non-denaturing conditions. It maps the N-terminus repair. Mutation involving p53 is found in a wide variety of malignant tumors, region of the p53 molecule in the region of amino acids 20 and 25. including breast, ovarian, bladder, colon, lung, and melanoma.
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oncentrated 0.5ml nly for mar ets outsi e t e S or S mar et mar et S or outsi e t e S mar ets for nly oncentrated 1ml I BALB/C mice were injected with mouse recombinant Prokaryotic recombinant protein corresponding to a region which region a to corresponding protein recombinant Prokaryotic Mob2 1-05 C Anaplastic large cell lymphoma (ALCL) is usually composed of large of composed usually is (ALCL) lymphoma cell large Anaplastic This antibody is specific to a protein of 57 kDa known as p57Kip2 a cell a p57Kip2 as known kDa 57 of protein a to specific is antibody This Anaplastic lymphoma Anaplastic Control: Colon carcinoma Colon Control: IgG1 Cytoplasmic and/or nuclear and/or Cytoplasmic Localization: IgG2b, kappa IgG2b, Nuclear Localization: 5A4 57P06 ------Immunogen: NPM-ALK of C-terminus the of part and domain catalytic kinase tyrosine the spans (41-520 Āaa). transcript Isotype: Positive Cellular Specificity: pleomorphic cells, which express CD30 antigen and the epithelial membrane These tumor antigen cells (EMA). tend to occur in younger patients and may be associated with cutaneous and extranodal involvement. Large cell lymphoma account for approximately 25% of all non-Hodgkin lymphomas in children and adults. young Monoclonal Mouse Anti-Human p naplastic Lymp oma inase Lymp oma p naplastic Clone: 1ml Mob416 Concentrated No : Catalog 0.5ml Mob416-05 Concentrated egulatory Status: Monoclonal Mouse Anti-Human Monoclonal p ip Clone: Mob2 1 C No : Catalog I egulatory Status: Immunogen: p57Kip2protein. Isotype: Positive Cellular Specificity: cycle regulatory mitotic inhibitor. This antibody does not cross-react with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes and a negative regulator of cell proliferation. cell of regulator negative a and complexes Formalin fixed paraffin embedded anaplastic lymphoma stained with p80/ALK antibody (Mob416). paraffin fixed Formalin Formalin fixed paraffin embedded human placenta stained with p57Kip2 embedded human placenta (Mob291). antibody paraffin fixed Formalin 5 P P
3 6 0 Nuclear A synthetic peptide from human p57Kip2 protein. p57Kip2 human from peptide synthetic A Recombinant human wild type P53 protein expressed in E. coli. E. in expressed protein P53 type wild human Recombinant This antibody reacts with a 57 kDa protein. p57Kip2 protein is an This antibody reacts with wild as well as mutant types of P53 protein. protein. P53 of types mutant as well as wild with reacts antibody This Colon carcinoma Colon Control: Breast carcinoma Breast Control: IgG2b, kappa IgG2b, Nuclear Localization: DO-7 ------Immunogen: Positive Cellular Specificity: inhibitor of several G1 cyclin complexes proliferation. and The is gene encoding a human negative p57Kip2 regulator protein of is cell located on p ip Specificity: It recognizes an epitope in the N-terminus in 22-76% of This antibody can be demonstrated amino acids 35 to 45. between of p53 cancers. protein, testes and known lung breast, to bladder, stomach, reside colon, the Immunogen: Isotype: Positive Localization: Cellular RP104 Concentrated 1ml RP104 Concentrated No : Catalog I egulatory Status: 0.5ml RP104-05 Concentrated Polyclonal Rabbit Anti-Human Polyclonal chromosome 11p15.5, a region implicated in sporadic cancers, Wilm’s tumor and tumor Wilm’s cancers, sporadic in implicated region a 11p15.5, chromosome syndrome. Beckwith-Wiedemann Monoclonal Mouse Anti-Human Monoclonal p egulatory Status: I egulatory Status: Clone: 1ml Mob082 Concentrated No : Catalog 6ml PDM013 Prediluted 10ml Prediluted PDM013-10MM 0.5ml Mob082-05 Concentrated Formalin fixed paraffin embedded human placenta stained with p57Kip2 embedded human placenta antibody (RP104). paraffin fixed Formalin Formalin fixed paraffin embedded colon carcinoma stained with p53 antibody (Mob082). carcinoma embedded colon paraffin fixed Formalin Page 92-96 Hard Edit.pdf 4 Page 92-96 Hard Edit.pdf 5 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedprostatecarcinoma stainedwithp504Santibody(RP134). (RMAB053). Formalin fixed paraffin embeddedhumanlargeintestinestainedwithp120Cateninantibody epai rtis h mmrn imnsann pten p2 Catenin p120 the breast pattern. and in identifying early lesions of immunostaining lobular neoplasia. membrane antibody is useful in the differentiation of lobular carcinoma from retains ductal carcinoma of neoplasia Catenin shows a diffuse cytoplasmic immunostaining pattern, while breast ductal Monoclonal Rabbit Anti-Human Monoclonal Rabbit PDR046Prediluted 6ml Status: egulatory PDR046-10RPPrediluted 10ml RP134-05Concentrated 0.5ml Catalog No : RP134Concentrated 1ml P504S can be used as a positive marker for PIN. hyperplasia. adenomatous atypical and (PIN) neoplasia intraepithelial prostatic high-grade prostate: of lesions premalignant stains It tissue. in prostatic not benign but adenocarcinoma prostatic in found is protein p504S of Expression that encodes a protein involved in the β-oxidation of branched chain fatty acids. Specificity: Cellular Positive Immunogen: C p S α et ylacyl Co acemase Polyclonal Anti-Human Rabbit with poor progress in colon cancer patients. In breast lobular neoplasia, anti p120 lungcancer, pancreatic cancer, gastric cancer and colon cancers and is associated Specificity: Cellular Positive Isotype: Catenin protein. Immunogen: Status: egulatory I RMPD053Prediluted 6ml Catalog No : RMAB053 Concentrated 0.5ml Clone: p Catenin ------EP66 Localization: Cytoplasmic Localization: Membrane/ Cytoplasmic Rabbit IgG Control: Prostate carcinoma Control: Breast, large intestine, breast lobular carcinoma P504S has been recently described as a prostate cancer-specific gene in observed been has Catenin p120 of accumulation Cytoplasmic A synthetic human AMACR peptide. snhtc etd crepnig o eius n ua p120 human in residues to corresponding peptide synthetic A I nly for mar ets outsi et e S or S mar et seein e III 360 P
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6 Formalin fixed paraffin embeddedhumanprostatecarcinoma stainedwithp504s(RMAB078). (RP030). Formalin fixed paraffin embeddedhumanpancreasstainedwithPancreatic Polypeptide antibody focus of prostate carcinoma on needle biopsy. small of diagnosis the confirm to help could marker negative a as P63) or βE12 (34 staining cell basal with along marker positive a as P504S Using hyperplasia. adenomatous atypical and (PIN) neoplasia intraepithelial prostatic high-grade The tissues. paraffin-embedded expression of P504S is also in detected in two premalignant lesions of the prostate: staining immunohistochemical by tissue prostatic benign in not but adenocarcinomaprostatic in found is protein P504S of expression High tissues. prostate malignant in microarrays and subtraction branched-chain branched-chain fatty acids. Recently, P504S was identified through cDNA library RP030-05Concentrated 0.5ml Status: egulatory I Catalog No : RP030Concentrated 1ml 54 (MC) s n seta ezm i te -xdto of β-oxidation the in enzyme essential an is (AMACR) P504S Specificity: Cellular Positive Isotype: Immunogen: RMPD078-10RMPrediluted 10ml RMAB078-1 Concentrated 1ml Status: egulatory RMPD078Prediluted 6ml Catalog No : RMAB078 Concentrated 0.5ml Clone: p s Anti-Human Monoclonal Rabbit and medium sized ducts and acinar cells. ofislets, exocrineperiphery pancreatic parenchyma andtheepitheliumofsmall Specificity: Cellular Localization: Cytoplasmic Positive limpet hemocyanin. Immunogen: Pancreatic Polypepti e Polyclonal Anti-Human Rabbit ------13H4 Localization: Cytoplasmic Rabbit IgG Control: Prostate carcinoma Control: Pancreas hs nioy ecs ih acetc oyetd. t tis the stains It polypeptide. pancreatic with reacts antibody This Human AMACR (P504S) polypeptide. Synthetic human pancreatic polypeptide conjugated to keyhole to conjugated polypeptide pancreatic human Synthetic I nly for mar ets outsi et e S or S mar et seein e III 3 60 P
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2/17/17 5:06PM Primary Antibodies 2/17/17 5:07 PM the NEW has been www.dbiosys.com nlike BC12 P
P , , 8 antibody 3 6 0 3 6 0 8 rabbit polyclonal antibody. 8 stains nuclei exclusively and performs well in performswell and exclusively nuclei stains 8 8 targets antigens found in normal kidney, thyroid and thus providing superior specificity. The expression of the 8 is expressed in a high percentage of renal cell carcinomas and carcinomas cell renal of percentage high a in expressed is 8 8, this mouse monoclonal antibody does not stain B-cells, and colon 7 protein. PA human of (aa300-600) fragment Recombinant ag0306. Pax-7 is a protein specifically expressed in cultured satellite cell- PA Rhabdomyosarcoma Control: Normal kidney, renal cell, or serous ovarian carcinomas ovarian serous or cell, renal kidney, Normal Control: IgG1, kappa IgG1, IgG1 Nuclear Localization: Nuclear Localization: F F DBM15.29 BC12 ------Monoclonal Mouse Anti-Human PAX- Immunogen: Monoclonal Mouse Anti-Human Monoclonal PAX- Immunogen: Isotype: Positive Cellular Specificity: derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar I egulatory Status: Clone: 6ml PDM180 Prediluted o.: Catalog 10ml PDM180-10MM Prediluted Clone: 1ml Mob503 Concentrated o.: Catalog 10ml Prediluted PDM231-10MM I egulatory Status: 6ml PDM231 Prediluted Isotype: Positive rhabdomyosarcoma). rhabdomyosarcoma). Cellular Specificity: ovarian cancers. This mouse monoclonal PA designed designed to target restricted epitopes, and exhibits higher specificity and formalin-fixed paraffin-embedded tissues. paraffin-embedded formalin-fixed provides provides sharper staining than the PA polyclonal polyclonal PA does not recognize epitopes of pancreatic origin and neuroendocrine cells in stomach and mouse monoclonal PA PA ovary. normal not cervix,but Formalin fixed paraffin embedded renal cell carcinoma stained with PAX-8 antibody (PDM180). carcinoma embedded renal cell paraffin fixed Formalin Formalin fixed paraffin embedded human rhabdomyosarcoma stained with PAX-7 (Mob503). stained with PAX-7 embedded human rhabdomyosarcoma paraffin fixed Formalin 97 NEW P P
, , 3 6 0 rediluted 10ml rediluted
oncentrated 1ml rediluted 6ml rediluted I Nuclear Nuclear Pancreas Tonsil protein. 6 PA human of 1-300) aa minus (N-ter fragment Recombinant A synthetic cyclic peptide from the antigen C-terminus. antigenthe from peptidecyclic synthetic A PDM21 P PDM21 -10MM P Lesions in the Pax6 gene account for most cases of aniridia, a congenital The PA. proteins are important regulators in early development, and F F Control: IgG1, kappa IgG1, Localization: Localization:
B 6 DBM15.2 ------Monolonal Mouse Anti-Human PAX-6 Immunogen: Clone: 0.5ml Concentrated RMAB027 o.: Catalog egulatory Status: 6ml RMPD027 Prediluted Monoclonal RabbitMonoclonal Anti-Human PAX- I egulatory Status: Clone: Mob 9 C o.: Catalog Isotype: IgG Isotype: Control: Positive Cellular Specificity: alterations in the expression of their genes are thought to contribute to neoplastic transformation. The 5 PA gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expressionIts differentiation. B-cellofstages late not but early, at expressed isthat (BSAP) geneproductmay 5 PA hasalso beendetectedtherefore, inCNS developingand testis not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. and duringcommitmentlineagecellBfor requiredcontinuouslyonly notisexpression Pax-5 Immunogen: Isotype: Positive early B cell development but also for B lineage maintenance. Pax-5 is found in most casesmostin found is Pax-5 maintenance. lineageB for also but development cellB early Cellular Specificity: of mature and precursor B-cell non-Hodgkin lymphomas/leukemias. Pax-5 is not detected in multiple myeloma and solitary plasmacytoma, making it useful for such malformation of the eye, chiefly characterized by iris hypoplasia, which can cause differentiation. Diffuse large B-cell lymphomas do express Pax-5 except for those with blindness. Pax6 is involved in other anterior segment malformations besides aniridia, terminal B-cell differentiation. T-cell neoplasms do not stain with -5 anti-Pax however such as er s Pet anomaly, a major error in the embryonic development of the eye with there is a strong association with CD20 expression. CD20with association strong ais there corneal clouding with variable iridolenticulocornealThe adhesions. Pax6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA- binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, gene produces twoproducesgene 6 PA humanThe sequences.DNAconsensus respectivebindwhich alternatively spliced isoforms that have the distinct structure of the paired domain. paired the ofstructure distinct the have that isoforms spliced alternatively Formalin fixed paraffin embedded human pancreas stained with PAX-6 (Mob494). embedded human pancreas stained with PAX-6 paraffin fixed Formalin Formalin fixed paraffin embedded human tonsil stained with PAX-5 antibody (RMAB027). embedded human tonsil stained with paraffin fixed Formalin Page 97-101 Hard Edit.pdf 1 Page 97-101 Hard Edit.pdf 2 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumansquamouslungcarcinoma stainedwithPD1(Mob475). Formalin fixed paraffin embeddedhumanrenalcell carcinoma stainedwithPAX-8 (Mob522). an an additional immunohistochemical marker for renal epithelial tumors. renal renal cell carcinoma, nephroblastoma, and seminoma. PA mucinous adenocarcinomas. PA adenocarcinomas. mucinous serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian ovarian primary in rarely only but carcinomas, cell clear and endometrioid, serous, vra srae pteil el. PA cells. epithelial surface ovarian renal cell cancer. broadening their scope beyond classic immunogenic tumors like melanoma and mucosal mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal oimngnc acr sc a nnsalcl ln ad oo cancers, colon and lung non–small-cell as such cancers nonimmunogenic akr f niimnbatc ypoa as poue epne in responses produce also lymphoma. angioimmunoblastic of marker a Anti-PDCD1is function. cytolytic T-celland proliferation,production, cytokine Engagement of PD1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits Specificity: transmembrane receptor expressed on activated T-cells, B-cells, and myeloid cells. Cellular Positive Isotype: Positive PDM257-10MMPrediluted 10ml PDM257Prediluted 6ml Status: egulatory I Catalog o.: Mob522Concentrated 1ml Clone: PAX- Monoclonal MouseAnti-Human PDM190Prediluted 6ml Status: egulatory I PDM190-10MMPrediluted 10ml Catalog o.: Mob 75C Clone: Specificity: Cellular Isotype: Immunogen: P F Monoclonal MouseAnti-Human Immunogen: ------DBM15. 8 DBM15.5
Localization: Localization: IgG2a
Control: Localization: IgG1, kappa Control: PA. -8 -8 is expressed in the thyroid (and associated carcinomas), non-ciliated PA. PD1, or CD279/PDCD1 (programmed cell death-1 protein), is a type I Recombinant Recombinant human PA 8 protein. F Recombinant full-length human PDCD1 protein. Renal Renal cell carcinoma Squamous lung carcinoma Nuclear Nuclear Cytoplasm and cell surface oncentrated 1ml -8 expression is reported in renal tubules as well as as well as tubules renal in reported is expression -8 -8 is expressed in a high percentage of ovarian ovarian of percentage high a in expressed is -8 360 3 60 , ,
P -8 -8 antibody may be used as P NEW NEW 98 Formalin fixed paraffin (Mob310). embeddedhumanspleenstainedwithPerforin Formalin fixed paraffin embedded human prostate carcinoma stained with PIN 5 Cocktail (PDR057). Cocktail 5 PIN with carcinomastained prostate human Formalinembedded paraffinfixed cytokeratin) cytokeratin) offers utility in diagnosing PIN in difficult cases where tissue may be limited. p50 S prostate carcinoma in small foci of needle biopsies. The positive prostate cancer marker, cancer prostate positive The biopsies. needle of foci small in carcinoma prostate The The PIN5 antibody combination useful for may confirming be the particularly diagnosis of atypicaladenomatous hyperplasia. ise An tissue. p50 S P50 S prostate cancer tissue. cancers. As cancers. epithelial cells. Benign prostate tissue contains basal cells, which are absent in prostate prostate in absent are which cells, basal contains tissue prostate Benign cells. epithelial High molecular weight cytokeratin and p63 are commonly used markers of basal basal of markers used commonly are p63 and cytokeratin weight molecular High neoplasia (PIN). shown to be relevant in diagnosing the premalignant condition, prostatic intraepithelial intraepithelial prostatic condition, premalignant the diagnosing in relevant be to shown mimicking cancer from prostate carcinomas. In particular, these markers have been been have markers these particular, In carcinomas. prostate from cancer mimicking cytokeratin markers has been shown to be useful for distinguishing benign conditions conditions benign distinguishing for useful be to shown been has markers cytokeratin Specificity: Cytoplasmic Cellular egulatory Status: egulatory Catalog o.: PDR057Prediluted 6ml Clone: target cells by of membrane cytolysis damage and mediates apoptosis. Perforin cells. killer natural and T-lymphocytes cytotoxic cytolytic pore-forming protein. Perforin is a specific marker of functionally active Specificity: Cellular Positive Isotype: C-terminus of the perforin molecule. Immunogen: Mob310-1-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob310-1Concentrated 1ml Clone: Perforin Monoclonal MouseAnti-Human Positive anti-p S a it . . ) anti-p , ouseanti-CytokeratinPI ( a it Cocktail ------has been recently described as a prostate cancer-specific gene. Expression of of Expression gene. cancer-specific prostate a as described recently been has (AMACR), in conjunction with the negative basal cell markers markers cell basal negative the with conjunction in (AMACR), (AMACR) protein is seen in prostatic adenocarcinoma but not in benign prostatic prostatic benign in not but adenocarcinoma prostatic in seen is protein (AMACR) Mouse antiCytokeratinH.M. Clone:3 E12 5B10
Control: Localization: Localization: Cytoplasmic Control: Spleen IgG1 ti-p5 0S p 0 The combined detection of F hs nioy s pcfc o 7 ka rti, hc i a potent a is which protein, kDa 70 a to specific is antibody This is an isoform of p63, it also stains basal epithelial cells and can be used in in used be can and cells epithelial basal stains also it p63, of isoform an is Recombinant protein corresponding to an external region of the Prostatic intraepithelial neoplasia (PIN) stains premalignant lesions of prostate: high-grade PIN and and PIN high-grade prostate: of lesions premalignant stains I
p 0: Nuclear Cytokeratin
(Only for markets outsidetheU.S. For U.S. market, seeindex III.) p50 S, F
p 0 (HM and high molecular weight ): ): Cytoplasmic ,
P (p 0 P50 S ,
P and and (AMACR): H.M.
2/17/17 5:07PM Polyclonal Rabbit Anti-Human Monoclonal Mouse Anti-Human Platelet-Derived Growth Factor (PDGF) F,/ P H Pneumocystis carinii F,/ P E Catalog No.: RP1 5 Concentrated 1ml Clone: 3F6 RP1 5-05 Concentrated 0.5ml Catalog No.: Mob091 Concentrated 1ml Mob091-05 Concentrated 0.5ml Regulatory Status: IVD Regulatory Status: IVD (Only for markets outside the U.S. For U.S. market, see index III.)
Formalin fixed paraffin embedded human colon carcinoma stained with PDGF antibody (RP145). Immunogen: A synthetic peptide derived from aa 101-116 of the human PDGF B chain. Formalin fixed paraffin embedded infected tissue stained with Pneumocystis carinii antibody Positive Control: Angiosarcoma (Mob091). Cellular Localization: Cytoplasmic Immunogen: BALB/C mice were injected with P. carinii cysts isolated from human lung. Specificity: Platelet-Derived Growth Factor (PDGF) is the major serum mitogen for cells Isotype: IgM, kappa of mesenchymal origin in humans. The biologically active protein is a dimer composed Positive Control: Infected lung of two related polypeptides designated A and B. The PDGF protein has been implicated Cellular Localization: Alveolar spaces both directly as well as indirectly in several pathological states including neoplasia, Specificity: This antibody reacts with P. carinii in the fixed human tissues. The arthritis, arteriosclerosis and bone marrow sclerosis. This antibody is specific for the B antibody is specific against an 82 kDa parasite specific polypeptide. It does not form and reacts with PDGF (AB) and PDGF (BB) protein. cross-react with G. lamblia, T. gondii, T. cruzi, L. tropica, E. histolytica, C. albicans and P. falciparum. ------Antibodies Primary ------Monoclonal Mouse Anti-Human PMS2 F,/ P H Polyclonal Rabbit Anti-Human Clone: A16- Poly ADP-Ribose Polymerase, (PARP) F,/ P H Catalog No.: PDM171 Prediluted 6ml Catalog No.: RP067 Concentrated 1ml PDM171-10MM Prediluted 10ml 3 6 0 RP067-05 Concentrated 0.5ml
Regulatory Status: IVD Regulatory Status: IVD (Only for markets outside the U.S. For U.S. market, see index III.)
Formalin fixed paraffin embedded colon carcinoma stained with PMS2 (PDM171). Formalin fixed paraffin embedded human tonsil stained with PARP antibody (RP067). Immunogen: Recombinant human PMS2 (C-terminus). Immunogen: A synthetic peptide from the N-terminal region of human PARP. Isotype: IgG1, κ Positive Control: Tonsil Positive Control: Colon carcinoma, tonsil Cellular Localization: Nuclear Cellular Localization: Nuclear Specificity: This antibody reacts with a 116 kDa protein, known as PARP. Specificity: Postmeiotic segregation increased 2 or PMS2 was originally Proteolysis of PARP to its stable 85 kDa fragment is an early marker of apoptosis discovered in S. cerevisiae and is part of the mismatch repair system. It resides on and is mediated by caspase (CPP32) protein. PARP uses nicotinamide adenine 7p22.2 and its gene product partners with MLH1 to help detect mismatches in dinucleotide (oxidized form) as a substrate to catalyze the transfer of ADP-ribose DNA. Mutations in PMS2 have been reported in about two percent of families with to a variety of nuclear acceptors. Lynch syndrome (hereditary nonpolyposis colorectal cancer).
99 www.dbiosys.com
Page 97-101 Hard Edit.pdf 3 2/17/17 5:07 PM Page 97-101 Hard Edit.pdf 4 Primary Antibodies www.dbiosys.com (RMAB002). Formalin fixed paraffin embeddedbreastcarcinoma stainedwithProgesterone Receptor antibody (RMAB052). Formalin fixed paraffin embeddedbreastcarcinoma stainedwithProgesterone Receptor antibody egulatory Status: egulatory RMPD052Prediluted 6ml Catalog o.: RMAB052 Concentrated 0.5ml Clone: Progesterone eceptor Monoclonal Rabbit Anti-Human Monoclonal Rabbit RMPD002Prediluted 6ml Status: egulatory Catalog o.: RMAB002 Concentrated 0.5ml Clone: prognostic to indicator in some response studies. a as ER predicting to superior proved has PgR in survival. estimating and both therapy endocrine ER, to information supplementary provides estrogen responsive a indicates PgR receptor (ER)pathway. of Anumber ofstudieshave shownthatPgR determination expression that proposed been has Specificity: Cellular Positive Isotype: 12-526 Āaa. Immunogen: Progesterone eceptor Anti-Human Monoclonal Rabbit epithelial cells of breast, ovary and endometrium. transdominant repressor of PR-B. This anti-PR recognize both PR-A and B. It labels ofprogesterone-responsivean activator genes, whilePR-Afunctions asastrong as functions PR-B have activities. they transcriptional opposite affinities binding ligand- and DNA- similar have PR of forms two the (11 ĀkDa).hile Ā PR-B and B humans as two isoforms ĀPR-Ain exists PR family.receptor (9 ĀkDa)steroid the of member a which is lacks and factor the transcription first 16 Āamino acids of PR- Specificity: Cellular Localization: Nuclear Positive Isotype: of human PR protein. Immunogen: ------EP2 SP2 Localization: Nuclear Rabbit IgG Control: Breast carcinoma Control: Breast carcinoma IgG The progesterone receptor (PgR) is an estrogen-regulated protein. It ligand-activated a is (PR), receptor progesterone human The A synthetic peptide corresponding to residues near the N-terminus eobnn poen noig ua poetrn receptor progesterone human encoding protein Recombinant I I (Only for markets outsidetheU.S. For U.S. market, seeindex III.) (Only for markets outsidetheU.S. For U.S. market, seeindex III.) F F , ,
P P
100 (RMAB028). Formalin fixed paraffin embeddedbreastcarcinoma stainedwithProgesterone Receptor antibody antibody (RP146). Formalin fixed paraffin embeddedhumanbreastcarcinoma stainedwithProgesterone Receptor in some studies. well as estimating survival. PR has proved superior to ER as a prognostic indicator supplementary information to ER in predicting response to endocrine therapy as provides determination PR that shown have studies of number pathway.A (ER) receptor estrogen responsive a indicates PR of expression that proposed been 11q22), it has two main forms, A and B, that differ in their molecular weight. (chromosomeIt has gene single a by Expressed progesterone. binds specifically that Specificity: Cellular Positive Isotype: Immunogen: RMPD028Prediluted 6ml Status: egulatory Catalog o.: RMAB028 Concentrated 0.5ml Clone: Anti-Human Monoclonal Rabbit Progesterone eceptor egulatory Status: egulatory Catalog o.: RP1 6C Progesterone eceptor Polyclonal Anti-Human Rabbit euae xrsin f h tre gns Nl mtto i P gn las to leads gene PR in mutation pleiotropic Null reproductive abnormalities. genes. target the of to expressionfactor transcription regulate activated ligand a as acts It (A-form). 81kDa and form) Specificity: Cellular Positive Control: Breast carcinoma progesterone receptor. Immunogen: Immunogen: ------B 7 Localization: Nuclear Localization: Nuclear IgG Control: Breast carcinoma The progesterone receptor (PR) is an intracellular steroid receptor steroid intracellular an is (PR) receptor progesterone The RP1 6-05C Human progesterone receptor (PR) exists in two forms: 116kDa (B- 116kDa forms: two in exists (PR) receptor progesterone Human A synthetic cyclic peptide from the antigen C-terminus. snhtc etd drvd rm h Ctria o human of C-terminal the from derived peptide synthetic A I I oncentrated 1ml oncentrated 0.5ml (Only for markets outsidetheU.S. For U.S. market, seeindex III.) (Only for markets outsidetheU.S. For U.S. market, seeindex III.) F F , ,
P P
2/17/17 5:07PM Primary Antibodies 2/17/17 5:07 PM www.dbiosys.com H P P ,/ , 3 6 0 .) .) F F ) ) (for U.S. market only market U.S. (for (for U.S. market only market U.S. (for oncentrated 1ml IVD IVD A synthetic peptide corresponding to residues near the C-terminus the near residues to corresponding peptide synthetic A Prokaryotic recombinant protein corresponding to a portion of the of portion a to corresponding protein recombinant Prokaryotic This antibody reacts with human prostate specific antigen. specific prostate human with reacts antibody This Prostate-specific antigen (PSA) is a serine protease member of the Rabbit IgG Rabbit Prostate Control: Prostate carcinoma Prostate Control: IgG1. Cytoplasm Localization: Cytoplasmic Localization: EP109 35H9 ------Monoclonal Rabbit Anti-Human (PSA) Specific Antigen Prostate Clone: 0.5ml Concentrated RMAB065 No.: Catalog Regulatory Status: 6ml RMPD065 Prediluted Immunogen: protein. PSA human of Isotype: Positive Cellular Specificity: human glandular kallikrein family. It and is hyperplastic, normal, synthesized in found in is It the serum. into prostate diffused ductal and epithelium and acinar malignant prostate tissue. Low expression of PSA has been reported in normal other or tumor tissues carcinomas. mammary such rare and carcinoma, as duct salivary urethral, periurethral, and perianal glands, Monoclonal Mouse Anti-Human Monoclonal (PSA Specific Antigen Prostate Clone: Mob08 -1 C No.: Catalog 10ml Prediluted PDM087-1-10MM Regulatory Status: 6ml PDM087-1 Prediluted Immunogen: molecule. antigen specific prostate the of N-terminus Isotype: Positive Cellular Specificity: Formalin Formalin fixed paraffin embedded human prostate carcinoma stained with PSA antibody (RMAB065). Formalin Formalin fixed paraffin embedded human prostate carcinoma stained with PSA antibody (PDM087-1). 101 H P ,/ H F P ,/ F Nuclear Cytoplasmic Tonsil BALB/C mice were injected with purified recombinant rat Rat PCNA made in the protein A expression vector pR1T2T. vector expression A protein the in made PCNA Rat PCNA is essential for cellular DNA synthesis. This antibody reacts antibody This DNA cellular synthesis. PCNA is for essential This antibody is specific to a 30 kDa protein known as prohibitin. Control: IgG2a, kappa IgG2a, Localization: Localization: Heart Control:
IgG1 Localization: Localization:
II-1 -10 PC10 ------Immunogen: Immunogen: Specificity: located in the inner membrane conserved protein is an evolutionarily Prohibitin of mitochondria. Prohibitin shows proposed to play a role antiproliferative in normal cell cycle activity regulation, replicative senescence, and has been Proliferating Cell Nuclear Antigen (PCNA) Nuclear Antigen Cell Proliferating prohibitin protein. prohibitin Isotype: Positive Cellular Immunogen: Monoclonal Mouse Anti-Human Monoclonal Prohibitin Monoclonal Mouse Anti-Human Clone: 1ml Mob323 Concentrated No.: Catalog 0.5ml Mob323-05 Concentrated 6ml Prediluted PDM152 IVD Regulatory Status: Clone: 1ml Mob083 Concentrated No.: Catalog 0.5ml Mob083-05 Concentrated 6ml PDM01 Prediluted IVD Regulatory Status: cellular immortalization and tumor suppression. tumor and immortalization cellular Isotype: Positive Cellular Specificity: with with proliferating cells in a wide range of normal The tissues. significance of PCNA PCNA immunoreactivity in tumors in not fully established. in However, non- Hodgkin Hodgkin lymphoma a linear relation between . i-67 and PCNA staining has been demostrated. been Formalin fixed paraffin embedded human tonsil stained with PCNA antibody (Mob083). paraffin fixed Formalin Formalin fixed paraffin embedded liver hepatocellular carcinoma stained with Prohibitin antibody stained with Prohibitin carcinoma embedded liver hepatocellular paraffin fixed Formalin (Mob323). Page 97-101 Hard Edit.pdf 5 Page 102-106 Hard Edit.pdf 1 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanprostatecarcinoma stainedwithPSA(Mob508). Formalin fixed paraffin embeddedprostatecarcinoma stainedwithPSAantibody(RP033). Immunogen: prostate hyperplasia. higher A (ACT). inprostate cancerthaninbenign ofserumPSAiscomplexedtoACT proportion alpha-1-antichymotrypsin inhibitor, liver- protease a to serine complexed derived predominantly is It carcinoma. prostatic with patients of sera prostate the in detected the be can PSA by fluid. seminal producedin abundant and exclusively epithelium, family) (kallikrein protease serine like PSAisachymotrypsin- epitheliuminbothnormalandneoplastictissues. ductal Specificity: Cellular Positive Isotype: any other cell type has been observed. RP033-05Concentrated 0.5ml Status:Regulatory PDR007-10RPPrediluted 10ml PDR007Prediluted 6ml Catalog No.: RP033Concentrated 1ml PDM236Prediluted 6ml Status:Regulatory IVD PDM236-10MMPrediluted 10ml Catalog No.: Mob50 C Clone: rsaeSeii nie PA Prostate SpecificAntigen (PSA) Monolonal MouseAnti-Human with staining prostate.No neoplastic and normal of epithelium ductal prostatic Specificity: Cellular Positive Immunogen: Prostate SpecificAntigen (PSA) Polyclonal Anti-Human Rabbit ------DBM15.34 Localization: Cytoplasmic Localization: Cytoplasmic IgG1, kappa Control: Prostate Control: Prostate carcinoma This MAb ishighlyspecifictoPSAandstainsprostatic and secretory Ti atbd rat wt PA h sann ws bevd n the in observed was staining The PSA. with reacts antibody This Recombinant full-length human KLK3 protein. Prostate specific antigen isolated from human seminal plasma. IVD oncentrated 1ml
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3 60 , ,/ P P H NEW 102 Formalin fixed paraffin embeddedprostatecarcinoma stainedwithPSMAantibody(Mob440). Formalin fixed paraffin embeddedhumanprostatecarcinoma stainedwithPSMA(RMAB030). chromosomal chromosomal region. indicator indicator of prostate cancer. This gene likely arose from a duplication event of a nearby is upregulated in cancerous cells and is used as an effective diagnostic and prognostic and diagnostic effective an as used is and cancerous cells upregulated in is of pathological conditions associated with glutamate excitotoxicity. glutamate with associated conditions pathological of prostate form The hyperhomocysteinemia. hyperhomocysteinemia. The form expressed in the brain may be involved in a number f itr flts rslig n o bod oae ees n consequent and levels folate blood low in resulting folates, dietary of mutation in the intestinal form may be associated with impaired intestinal absorption absorption intestinal impaired with associated be may form intestinal the in mutation dipeptidase-1 in the brain, and prostate-specific membrane antigen in the prostate. A prostate. A the in antigen membrane prostate-specific and brain, the in dipeptidase-1 poly M2 Specificity: Specificity: Cellular Positive Isotype: variety variety a of of hormone- non-prostatic neovasculature solid tumors.the in in expresses expressed PSMA disease. levels metastatic and highest refractory with cancer, prostate of progression Mob440-05Concentrated 0.5ml Status:Regulatory Catalog No.: Mob440Concentrated 1ml Clone: RMPD030Prediluted 6ml Status:Regulatory Catalog No.: RMAB030 Concentrated 0.5ml Clone: rsai tsus PM epeso hs en hw t creae ih the with correlate to shown been has expression PSMA tissues. prostatic expressed innormalandmalignantprostatic epitheliumandinasubsetofnon- Specificity: Cellular Positive Isotype: and immunoaffinity purified PSMA. Immunogen: Prostate SpecificMembrane Antigen (PSMA) Monoclonal MouseAnti-Human Immunogen: Prostate SpecificMembrane Antigen (PSMA) Monoclonal Rabbit Anti-Human Monoclonal Rabbit ------ peptidase family. Three proteins distinct functionally are encoded, including folyl- -glutamate carboxypeptidase in the intestine, N-acetylated α-linked acidic acidic α-linked N-acetylated intestine, the in carboxypeptidase -glutamate 3 6 ...
Localization: IgG Control: Localization: Cytoplasmic and/or membrane IgG1 Control: Prostate carcinoma PMSA PMSA PSMA is a 750 amino acid type II membrane glycoprotein. PSMA is PSMA glycoprotein. membrane II type acid amino 750 a is PSMA A synthetic peptide from the C-terminus of human PSMA protein. BALB/C mice were injected with LNCaP membrane preparation membrane LNCaP with injected were mice BALB/C Prostate carcinoma ( LH1) IVD IVD Membrane is a type II transmembrane glycoprotein belonging to the (for U.S. market only (for U.S. market only .) .) F F ,/ ,/ P P H H 2/17/17 5:08PM Primary Antibodies 2/17/17 5:08 PM www.dbiosys.com H P
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oncentrated 0.5ml oncentrated 1ml IVD BALB/C mice were injected with recombinant Rad51 protein. Rad51 recombinant with injected were mice BALB/C Purified PGP .5 Āprotein isolated from bovine brain. bovine from isolated .5 Āprotein PGP Purified RP0 7-05 C This antibody is specific to a 37-43 kDa protein known as Rad51. This antibody reacts with a 25-27 kDa protein. Protein gene product gene Protein protein. kDa 25-27 a with reacts antibody This Testis Control: Pancreatic tumor Pancreatic Control: F IgG1, kappa IgG1, Nuclear Localization: Nuclear and cytoplasmic and Nuclear Localization: 51RAD01 ------Monoclonal Mouse Anti-Human Rad51 Clone: 1ml Mob324 Concentrated No.: Catalog 0.5ml Mob324-05 Concentrated Regulatory Status: Immunogen: Isotype: Positive Cellular Specificity: Rad51 is similar to to suggested RecA. been has Rad51 filament. nucleoprotein regular a within exchange Rad51 promotes regulation. proliferation homologous cell in and pairing recombination homologous in and involved be strand Polyclonal Rabbit Anti-Human Polyclonal Gene Product 9.5 (PGP9.5) Protein RP0 7 C No.: Catalog Immunogen: Positive Cellular Specificity: .5 Āis a ubiquitin C-terminal hydroxylase found in neurons and nerve of fibers segments cells, of neuroendocrinal many system, nervous peripheral and central cellular in present is It ova. and testis of cells Leydig spermatogonia, tubules, renal IVD Regulatory Status: inclusions inclusions and can be a useful neuronal marker and in the studies of neurodegenerative disorders. neurodegenerative Formalin fixed paraffin embedded human testis stained with Rad51 (Mob324). paraffin fixed Formalin Formalin fixed paraffin embedded human pancreas stained with PGP9.5 (RP087). paraffin fixed Formalin 103 NEW H P , P ,/ F F 3 6 0 3 6 0 oncentrated 0.5ml
oncentrated 1ml oncentrated 1ml IVD Recombinant human ACPP fragment. ACPP human Recombinant Recognizes a protein of 52kDa, identified as prostate specific acid Mob0 5-05 C This antibody is specific to human prostatic acid phosphatase. It Prostate Control: Prostate carcinoma Prostate Control: IgG1, kappa IgG1, IgG1, kappa IgG1, Cytoplasmic Localization: Cytoplasm Localization: DBM15.23 PAS /4L. ------Immunogen: Isotype: Positive Cellular Specificity: phosphatase (PSAP). This enzyme catalyzes the conversion of orthophosphoric monoester to found alcohol is PSAP and gland. prostate orthophosphate. the of It cells epithelial is the by synthesized secreted and under regulation androgen in non-neoplastic adult and fetal prostatic glands, primary and metastatic Monoclonal Mouse Anti-Human (PSAP) Phosphatase Acid Prostatic Immunogen: BALB/C mice were injected with purified prostatic acid Clone: Mob4 C No.: Catalog IVD Regulatory Status: 6ml PDM225 Prediluted 10ml PDM225-10MM Prediluted Monoclonal Mouse Anti-Human Monoclonal (PSAP) Phosphatase Acid Prostatic Clone: Mob0 5 C No.: Catalog 6ml Prediluted PDM037 10ml Prediluted PDM037-10MM Regulatory Status: prostatic prostatic carcinomas. It shows no staining carcinomas. in granulocytes, breast osteoclasts, parietal or cell renal cells, liver stomach, the of cells phosphatase from human seminal plasma. seminal human from phosphatase Isotype: Positive Cellular Specificity: reacts with the glandular epithelium of normal and hyperplastic prostate and adenocarcinoma. prostate with Formalin fixed paraffin embedded human prostate stained with PSAP (Mob498). paraffin fixed Formalin Formalin fixed paraffin embedded prostate carcinoma stained with PSAP antibody (Mob085). stained with PSAP antibody embedded prostate carcinoma paraffin fixed Formalin Page 102-106 Hard Edit.pdf 2 Page 102-106 Hard Edit.pdf 3 Primary Antibodies www.dbiosys.com Gene Protein antibody(Mob220). Formalin fixed paraffin embeddedhumancolon adenocarcinoma stainedwithRetinoblastoma Formalin fixed paraffin embedded human renal cell carcinoma stained with RCC antibody (PDM169). antibody RCC with stained carcinoma cell renal human embedded paraffin fixed Formalin and and epididymis. Gp200 glycoprotein is also localized in the breast lobules and ducts, parathyroid glands glands parathyroid ducts, and lobules breast the in localized also is glycoprotein Gp200 gp200 was expressed by by expressed was gp200 brush border of the proximal renal tebules and the luminal surface of Bowman.sborder of proximal brush the of renal surface luminal tebules the and capsule. Specificity: Cellular Positive Isotype: noted for those patients who had a tumor with an altered Rb protein with or with without protein vascular Rb invasion. altered an with tumor a had who patients those for was noted rate survival tumor-free poorer significantly A osteosarcoma. and cancer cancer.lung cell development and/or progression of bladder cancer as well as sarcoma and small Monoclonal MouseAnti-Human Mob220-05Concentrated 0.5ml Status: egulatory PDM111Prediluted 6ml Catalog o.: Mob220Concentrated 1ml Clone: ee a rttp o tmr upesr ee, a be ascae with associated been has genes, suppressor tumor of prototype a gene, Specificity: Cellular Positive Isotype: Immunogen: Protein etino lastoma ene ( ) Immunogen: Mob465-05Concentrated 0.5ml Status: egulatory PDM16 -10MMPrediluted 10ml PDM16 Prediluted 6ml Catalog o.: Mob465Concentrated 1ml Clone: enal Cell Carcinoma (gp )P Monoclonal MouseAnti-Human ------1 PN15
Localization: IgG1 Control: Localization: Nuclear IgG1, kappa Control: Colon carcinoma This antibody recognizes a 200 kD glycoprotein (gp200) localized in the the in localized (gp200) glycoprotein kD 200 a recognizes antibody This This antibody recognizes human retinoblastoma gene protein. Rb Rb protein. gene retinoblastoma human recognizes antibody This BALB/C BALB/C mice were tissue homogenate.with human renal injected cortical Recombinant human Rb protein. Normal kidney or renal cell kidney Normal carcinoma unctional Rb gene loss has been reported to occur in bladder in occur to reported been has loss gene Rb unctional Membrane I I 3
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P 104 Formalin fixed paraffin embeddedhumanintestinestainedwithRetOncoprotein (Mob326). Formalin fixed paraffin embeddedhumantonsilstainedwithRPA/p34 antibody(Mob329). in motor neurons in the spinal cord and hindbrain. developing cranial nerve ganglia, a subset of cells within dorsal root ganglia and the in system: nervous central the of regionsseveral in observed is Ret 10q11.2. to a member of the receptor tyrosine kinase family and is located on chromosome Specificity: Cellular Positive Isotype: extreme C-terminal cytoplasmic region of the human ret oncoprotein. antigen-catalyzed unwinding for unwinding antigen-catalyzed Mob326-05Concentrated 0.5ml Status: egulatory I Catalog o.: Mob326Concentrated 1ml Clone: Immunogen: et Oncoprotein Monoclonal MouseAnti-Human and (RPA70, RPA32 andRPA14 respectively). RPA isrequired f Human RPA is a stable heterotrimer of 70 kDa, 32-34 recombination.kDa and 11-14 kDa and subunits repair replication, DNA in involved is RPA(RPA). A protein Specificity: Cellular Positive Isotype: Immunogen: egulatory Status: egulatory I Catalog o.: Mob32 C Clone: P p Monoclonal MouseAnti-Human ------ . R T01 (sameas3 ) R T01 H Localization: Cytoplasmic Localization: Nuclear IgG1 IgG1, kappa Control: Small intestine Control: Tonsil Ret proto-oncogene encodes a cell surface glycoprotein belonging surface cell a encodes proto-oncogene Ret This antibody reacts with a 32-34 kDa protein known as replication as known protein kDa 32-34 a with reacts antibody This F
Mob32 -05C BALB/C mice were injected with recombinant protein encoding the BALB/C mice were injected with purified human RPA protein. F oncentrated 1ml oncentrated 0.5ml S 40 DNA and stimulates DNA polymerase α polymerase DNA stimulates and DNA , ,
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oncentrated 0.5ml rediluted 6ml rediluted I AB06 C F A synthetic peptide corresponding to residues on the C-terminus Affinity purified S-100 protein isolated from cow brain. cow from isolated protein S-100 purified Affinity RMPD06 P S100 Beta is a homodimeric member of the S100 superfamily. S100 is S100 superfamily. S100 the of member homodimeric a is Beta S100 This antibody reacts with cow S-100 protein a and b. It shows strong strong shows It b. and a protein S-100 cow with reacts antibody This Skin, melanoma Skin, Control: Melanoma Control: Rabbit IgG Rabbit Cytoplasm Localization: Cytoplasmic Localization: P32 ------Immunogen: protein. Beta S100 human of Isotype: Positive Cellular Specificity: that are differentially a family comprises of 1 Āmembers Ca2-binding Āproteins, expressed in a large number of cell types. The protein has been implicated S100 Beta is abundant and growth. in such as cell differentiation cellular processes in glial cells of the Antibody adipocytes. and central chondrocytes, and peripheral nervous system, in to S100 melanocytes, Beta also labels Langerhans cells, histiocytes, epithelial, myoepithelial cells and integrating reticular cells of lymphoid tissue, and tumors melanoma, tumors of diagnosis for marker useful a is Beta S100 originated cells. these from system. nervous of Monoclonal Rabbit Anti-Human S eta Clone: RM o.: Catalog I egulatory Status: S egulatory Status: Polyclonal Rabbit Anti-Human Polyclonal 1ml RP035 Concentrated o.: Catalog 6ml Prediluted PDR00 10ml Prediluted PDR00 -10RP 0.5ml Concentrated RP035-05 Immunogen: Positive Cellular Specificity: crossreactivity with with human positive stain skin the of S-100 cells Langerhans and Melanocytes a cells. ependymal and b. In the antibody. brain, this it labels glial and Formalin fixed paraffin embedded human melanoma stained with S-100 Beta (RMAB068). paraffin fixed Formalin Formalin fixed paraffin embedded human melanoma stained with S-100 antibody (PDR008). paraffin fixed Formalin 105 P P ,
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I BALB/C mice were immunized with purified bovine brain S-100 Purified bovine brain S-100β preparation. S-100β brain bovine Purified This antibody stains with S-100 protein. S-100 belongs to the family S-100 belongs to This antibody stains with S-100 protein. This antibody is specific against an epitope located on the β chain (i.e. (i.e. chain β the on located epitope an against specific is antibody This Melanoma Control: Melanoma Control: IgG1 IgG2a Cytoplasmic Localization: Cytoplasmic Localization: F SH-B1 4C4. ------Immunogen: Isotype: Positive Cellular Specificity: S-100ao). and S-100a in (i.e. S-100 of chain α the on not but S-100b) and S-100a in Monoclonal Mouse Anti-Human S F Immunogen: protein. Isotype: Positive Cellular Specificity: of calcium binding proteins such as calmodulin and troponin C. S-100a and S- is composed of an α S-100a two S-100 family. members of the are 100b proteins and β chain whereas S-100b is composed of two β chains. This antibody stains schwannomas, ependymomas, astrogliomas, almost all benign and malignant metastases. their and melanomas Clone: 1ml Mob111 Concentrated o.: Catalog 6ml PDM0 Prediluted 10ml PDM0 -10MM Prediluted 0.5ml Mob111-05 Concentrated egulatory Status: This antibody can be used to localize S-100a and S-100b in various tissue sections. tissue various in S-100b and S-100a localize to used be can antibody This S Monoclonal Mouse Anti-Human Monoclonal I egulatory Status: Clone: 0.5ml Mob377 Concentrated o.: Catalog 0.5ml Mob377-05 Concentrated 6ml PDM1 4Prediluted 10ml PDM1 4-10MMPrediluted Formalin fixed paraffin embedded human melanoma stained with S-100 antibody (Mob377). embedded human melanoma stained paraffin fixed Formalin Formalin fixed paraffin embedded human melanoma stained with S-100 antibody (PDM088). paraffin fixed Formalin Page 102-106 Hard Edit.pdf 4 Page 102-106 Hard Edit.pdf 5 Primary Antibodies www.dbiosys.com (RP081). Formalin fixed paraffin Receptor embeddedhumanpancreasstainedwithSomatostatin antibody Formalin fixed paraffin embeddedhumanappendixstainedwithSMMSantibody(Mob467). and peripheral nervous system. central in neurons of excitation and hormone growth and glucagons insulin, of protein and are involved in regulation of numerous processes including secretion two isoforms ofsomatostatinreceptor2,sst2Aandsst2B. They are coupledtoG receptor. Somatostatin family of receptors has five members, sst1-sst5, as well as Specificity: Cellular Positive somatostatin protein. Regulatory Status:Regulatory Catalog No.: RP0 1C Immunogen: Immunogen: Somatostatin Receptor Polyclonal Anti-Human Rabbit visceral and smooth vascular muscle cells stains and cells it that have smooth immunohistochemistry muscle-like characteristics. In myosin. non-muscle chain polypeptides of 200 and 204 kDa. It does not react with skeletal, cardiac, or Specificity: Cellular Positive Isotype: Immunogen: Regulatory Status:Regulatory IVD PDM175Prediluted 6ml Mob467-05Concentrated 0.5ml Catalog No.: Mob467Concentrated 1ml Clone: P/H Smooth MuscleMyosin (SMMS-1) Monoclonal MouseAnti-Human ------SMMS-1 Localization: Cytoplasmic Localization: Cytoplasmic IgG1 Control: Pancreas Control: Colon, appendix This antibody reacts with a 60 kDa protein, known as somatostatin as known protein, kDa 60 a with reacts antibody This Monoclonal anti-smooth muscle myosin reacts with myosin heavy heavy myosin with reacts myosin muscle anti-smooth Monoclonal RP0 1-05C Human uterus smooth muscle extract. snhtc etd drvd rm h Ctriu o rat of C-terminus the from derived peptide synthetic A IVD oncentrated 1ml oncentrated 0.5ml
F ,/ P H 106 Formalin fixed paraffin embeddedhumanmelanomastainedwithSOX10 (RMAB077). Formalin fixed paraffin embeddedhumanmelanomastainedwithSOX10 (Mob481). S -10 expression is also observed in mast cells. cells, Schwann melanocytes and in myoepithelial cells of expressedsalivary, bronchial and mammary is glands. it tissues, normal In melanomas. desmoplastic 1 i cniee a a ey eibe akr o rcgiig residual recognizing for marker reliable very a as considered is S -10 melanomas. desmoplastic in expressed strongly melanomas to moderately is while S -10 desmoplastic in expressed poorly are anti-Melan-A, and HMB-45 anti- as such markers, melanoma used Commonly -family. the S . of members Specificity: Cellular Positive Isotype: hexa-histidine tag. Immunogen: RMPD077-10RMPrediluted 10ml RMPD077Prediluted 6ml Status:Regulatory IVD Catalog No.: RMAB077 Concentrated 1ml Clone: SOX10 Anti-Human Monoclonal Rabbit aoiy f lgdnrgims n a ag pretg o atoyoa and astrocytomas poorly differentiated of glioblastomas percentage have large also been a shown and to oligodendrogliomasexpress S 10. of majority The 100,000. per 2 approximately of rate incidence annual an with melanoma, PDM220Prediluted 6ml Status:Regulatory PDM220-10MMPrediluted 10ml Catalog No.: Mob4 1C Clone: SOX10 F Monoclonal MouseAnti-Human el n dsolsi mlnms r rr vrat o ivsv cutaneous invasive of variants rare are melanomas desmoplastic and cell cell melanomas and has also been shown to importantly,be expressed Morein 100 of nevi. schwannomas.Spindle S 10 as has been shown to be expressed in 7-100 of desmoplastic such and spindle tumors benign and gliomas, type, tumors such as melanoma, and breast carcinomas of basal-like and triple malignantnegative in marker important an tissue.breast S 10 also and is melanocytes Specificity: Cellular Positive Isotype: S -10 protein. Immunogen: Immunogen: ------ P26 DBM15.10 Localization: Nuclear Localization: Nuclear IgG2b, kappa Rabbit Rabbit IgG Control: Melanoma Control: Melanoma F hs A i hgl seii ad os o cosrat ih other with cross-react not does and specific highly is MAB This i wdl epesd n oml ua tsus including tissues human normal in expressed widely is S 10 Recombinant fragment (aa115-26) Āof human S 10Āprotein with eobnn famn crepnig o eius n human in residues to corresponding fragment Recombinant IVD oncentrated 1ml
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BALB/C mice were injected with membrane enriched fraction of BALB/C mice were This This antibody recognizes a protein of 38kDa, identified as A synthetic peptide of human synaptophysin. This antibody is specific to an oncofetal antigen of >1,000 kDa known kDa >1,000 of antigen oncofetal an to specific is antibody This Rabbit IgG IgG1, kappa B72.3 SP11 ------Immunogen: metastasis. liver carcinoma a human breast Isotype: carcinoma Breast Control: Positive cell surface Cytoplasmic, Localization: Cellular Specificity: This antibody defines the or CA 72-4. (TAG-72) as tumor associated glycoprotein This antigen. antibody mucin stains carried the sialylated-Tn majority of human endometrial, ovarian, gastric, pancreatic, colorectal, including adenocarcinomas cancer. lung cell non-small and mammary Regulatory Status: IV Regulatory Status: Monoclonal Mouse Anti-Human 7 - TA -7 CA Clone: 1ml Mob288 Concentrated No.: Catalog 0.5ml Mob288-05 Concentrated 6ml PDM100 Prediluted 10ml PDM100-10MM Prediluted Formalin fixed paraffin embedded colon carcinoma stained with TAG-72 antibody (Mob288). stained with TAG-72 carcinoma embedded colon paraffin fixed Formalin Immunogen: Isotype: Pancreas Control: Positive Cytoplasmic Localization: Cellular Specificity: Monoclonal RabbitMonoclonal Anti-Human Synaptophysin Clone: 0.5ml Concentrated RMAB018 No.: Catalog IV Regulatory Status: 6ml RMPD018 Prediluted 10ml RMPD018-10RM Prediluted medulla, adrenal human of cells neuroendocrine normal labels It synaptophysin. carotid body, skin, pituitary gland, mucosa, thyroid, Paneth’s cells lung, in with combination In pancreas, labeled. the also are retina and gastrointestinal gastrointestinal cord, spinal brain, tract the in Neurons and gastric parietal cells. anti-chromogranin A and neoplasms. neuroendocrine and anti-NSE, cells neuroendocrine normal antisynaptophysinof identification is very useful in the Formalin Formalin fixed paraffin embedded human pancreas stained with Synaptophysin antibody (RMAB018). 107 P P
, , F Cytoplasmic Pancreas BALB/C mice were injected with a synthetic peptide encoding a A synthetic peptide derived from the C-terminal region of survivin. of region C-terminal the from derived peptide synthetic A This antibody is specific to a 38 kDa protein. Synaptophysin is an This antibody reacts with a 16.5 kDa protein, known as survivin. F Stomach Control: IgG1 Cytoplasmic Localization: S P02 ------Monoclonal Mouse Anti-Human Synaptophysin Immunogen: protein. synaptophysin the of end C-terminal the near region Isotype: Control: Positive Cellular Localization: Localization: Cellular Specificity: Clone: 1ml Mob399 Concentrated No.: Catalog IV Regulatory Status: 0.5ml Mob399-05 Concentrated glycoprotein occurring in presynaptic vesicles of neurons in the brain, spinal cord, cord, spinal brain, the in neurons of vesicles presynaptic in occurring glycoprotein antibody This junctions. neuromuscular in and medulla adrenal of vesicles retina, types. epithelial as well as neural of neoplasms neuroendocrine with reacts Formalin fixed paraffin embedded human pancreas stained with Synaptophysin antibody (Mob399). embedded human pancreas stained with Synaptophysin paraffin fixed Formalin Immunogen: Positive Cellular Specificity: of phase G2/M the in expressed is It proteins. apoptosis of inhibitor an is Survivin the cell cycle in a cycle-regulated At manner. the beginning of mitosis, survivin associates with microtubules of the microtubule mitotic interactions results in anti-apoptotic loss function of and survivin’s spindle. Disruption of survivin- activity. caspase-3 increased Polyclonal Rabbit Anti-Human Polyclonal Survivin RP068 Concentrated 1ml RP068 Concentrated No.: Catalog IV Regulatory Status: 0.5ml RP068-05 Concentrated Formalin fixed paraffin embedded human stomach stained with Survivin embedded human stomach stained paraffin antibody (RP068). fixed Formalin Page 107-116 Hard Edit.pdf 1 Page 107-116 Hard Edit.pdf 2 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedcolon carcinoma stainedwithTAG-72 antibody(Mob289). Formalin fixed paraffin embeddedhumanspleenstainedwithTRAcP (Mob490). pancreatic, ovarian, lung breast, and colon, gastric in expressedcancer. TAG-72is B72.3. of that than higher Ka a has it and reciprocalby radio-immunoassays fromcompetition B72.3 distinct be to shown been has antibody This 72-4. CA or (TAG-72) glycoprotein associated tumor as Specificity: Cellular Localization: Cytoplasm, cellsurface Positive Control: Breast carcinoma Isotype: Immunogen: PDM193-10MMPrediluted 10ml 360 PDM193Prediluted 6ml Mob289-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob289Concentrated 1ml Clone: A-2C 24 TAG-72/CA 72-4 Monoclonal MouseAnti-Human ih hg dge o sniiiy n seiiiy Ohr el sand ih this with stained cells antibody Other are specificity.tissue macrophages and and osteoclasts. sensitivity of degree high a with metabolic and bone diseases. Anti-TRAcP Cell antibodylabelsthecellsofHairy Leukemia (HCL) osteoporosis in and Osteoclastoma Encephalopathy, induced as such HIV- Disease, conditions Gaucher's Leukemia), pathological Cell (Hairy certain Reticuloendotheliosis Leukemic in increased is TRAcP of Expression ciae mcohgs nuos n edmtim uig pregnancy. during endometrium and neurons macrophages, activated reacts with both the isoforms. Normally, TRAcP is highly expressed by osteoclasts, resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb Specificity: Cellular Localization: Cytoplasmic (Lysosomes) Positive Control: Isotype: Immunogen: PDM203-10MMPrediluted 10ml PDM203Prediluted 6ml Status:Regulatory IVD Catalog No.: Mob490Concentrated 1ml Clone: Tartrate-Resistant Acid Phosphatase (TRAcP) Monoclonal MouseAnti-Human ------CC49 DBM15.2 IgG1 IgG2b, kappa This antibody is specific to an oncofetal antigen of >1,000 kDa known t eonzs poen f 5D, hc i ietfe a tartrate- as identified is which 35kDa, of protein a recognizes It BALB/Cmicewere withpurified injected TAG-72 protein. Recombinant full-length human ACP5 protein. Spleen 3 60 F ,/ P H NEW 108 Formalin fixed paraffin embeddedtonsilstainedwithTenascin C(PDM265). toa f ay epam, nldn gims bes, umu n lung and suamousĀ breast, gliomas, carcinomas. including neoplasms, many of stroma hyper-proliferativein in and diseases markedly increases and interfaces stromal and neo-vasculature the epithelial- certain to restricted is in it adults, In undifferentiatedtumors. of stroma and development during interactions epithelial mesenchymal with association in expressed glycoprotein matrix extracellular Specificity: Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: PDM265-10MMPrediluted 10ml Status:Regulatory PDM265Prediluted 6ml Catalog No.: Mob530Concentrated 1ml Clone: Tenascin C Monoclonal MouseAnti-Human Formalin fixed paraffin embeddedhumantonsilstainedwithTdt antibody(Mob097-1). Regulatory Status:Regulatory IVD motn rl i lmhct mtrto.Tt ak bt ad immature B and lymphocytes normally T found both in thymus marks and Tdtbone maturation. marrow. lymphocyte in role important an plays and rearrangement gene immunoglobulin during cells the in present Specificity: Cellular Localization: Nuclear Positive Control: Thymus Isotype: Immunogen: PDM096-10MMPrediluted 10ml PDM096Prediluted 6ml Mob097-1-05Concentrated 0.5ml Catalog No.: Mob097-1Concentrated 1ml Clone: emnlDoyuloiy rnfrs Tt Terminal Deoxynucleotidyl Transferase (Tdt) Monoclonal MouseAnti-Human ------DBM15.56 SEN28
IgG2a,kappa IgG1, kappa This antibody stains a 60kDa peptide in human lymphoblasts.human in peptide 60kDa Tdta stains antibody This is eacn i a utfntoa, iufd-ikd hexameric disulfide-linked multifunctional, a is C Tenascin Human breast carcinoma. BALB/C micewere with injected Tdt. Tonsil, s uamouslungcarcinoma IVD Connective tissuematrix
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P H F ,/ P H NEW 2/17/17 5:08PM Primary Antibodies 2/17/17 5:08 PM www.dbiosys.com P P , , F F BALB/C mice were immunized with purified human thyroglobulin. human purified with immunized were mice BALB/C BALB/C mice were injected with a recombinant full length human length full recombinant a with injected were mice BALB/C This antibody is specific to a 55 kDa protein known as platelet- IgG2a IgG1 1D4 P-GF.44C ------Monoclonal Mouse Anti-Human Thyroglo ulin Immunogen: Isotype: Thyroid Control: Positive Cytoplasmic Localization: Cellular Specificity: This antibody recognizes thyroglobulin in hyperplastic and Clone: 1ml Mob223 Concentrated No.: Catalog IV Regulatory Status: 0.5ml Mob223-05 Concentrated neoplastic thyroid. Thyroglobulin is of cells epithelial a follicular the by synthesized is protein Thyroglobulin subunits. identical of 670 kDa consisting of thyroid. two the Formalin fixed paraffin embedded thyroid stained with Thyroglobulin antibody (Mob223). paraffin fixed Formalin Monoclonal Mouse Anti-Human Monoclonal ndothelial Phosphorylase Platelet- erived Thymidine Factor ro th Cell Clone: 1ml Mob292 Concentrated No.: Catalog IV Regulatory Status: 0.5ml Mob292-05 Concentrated Immunogen: protein. (TP/PD-ECGF) phosphorylase thymidine Isotype: carcinoma Breast Control: Positive Nuclear Cytoplasmic, Localization: Cellular Specificity: derived endothelial growth factor (PD-ECGF), or thymidine phosphorylase (TP). High levels of TP/PD-ECGF fluoropyrimidine to are sensitivity observed increased with in associated are cancer TP/PD-ECGF patients. of High levels intracellular agents. chemotherapeutic Formalin fixed paraffin embedded colon carcinoma stained with Thymidine Phosphorylase antibody with Thymidine Phosphorylase stained carcinoma embedded colon paraffin fixed Formalin (Mob292). 109 NEW P , F P , F 3 6 0 A synthetic peptide corresponding to residues of human TdT BALB/C mice were injected with reduced and alkylated purified This antibody is specific to 450 kDa (non-reduced) and 170 to 180 kD 180 to 170 and (non-reduced) kDa 450 to specific is antibody This IgG1 Rabbit IgG A6.1 EP266 ------Monoclonal Mouse Anti-Human (TSP) Throm ospondin Immunogen: human TSP (fully denatured) from the supernatant of thrombin-activated Clone: 1ml Mob315 Concentrated No.: Catalog IV Regulatory Status: 0.5ml Mob315-05 Concentrated platelets. Isotype: Tonsil Control: Positive Cellular Localization: Secretory granules, Golgi complex, endoplasmic reticulum Specificity: α platelet from protein a is Thrombospondin thrombospondin. of form (reduced) granules. It is secreted at sites of involved platelet in activation the and differentiation aggregation of and leukocytes, is fibroblasts, cells. smooth endothelial muscle and Formalin fixed paraffin embedded human placenta stained with Thrombospondin antibody (Mob315). embedded human placenta paraffin fixed Formalin Monoclonal RabbitMonoclonal Anti-Human (Tdt)Transferase eoxynucleotidyl Terminal Immunogen: protein. Isotype: thymus Tonsil, Control: Positive Nuclear Localization: Cellular Specificity: Terminal deoxynucleotidyl transferase (TdT) is a uniue Ā DNA Clone: 1ml Concentrated RMAB084 No.: Catalog 6ml RMPD084 Prediluted 10ml RMPD084-10RM Prediluted polymerase that contributes to the generation of junctional B- diversity in antigen of precursors lymphoid in expressed is TdT lymphocytes. immature of receptors positive cells may be TdT lineage of in Foci T-cell thymus and bone and marrow. Regulatory Status: IV Regulatory Status: observed in peripheral lymphoid tissues. TdT is also present in malignant tumors malignant in present also is TdT tissues. lymphoid peripheral in observed of lymphoblastic lineage and thymoma. It is sensitive and lymphoma/leukemia. specific lymphoblastic marker for Formalin fixed paraffin embedded human tonsil stained with Tdt (RMPD084). embedded human tonsil stained with Tdt paraffin fixed Formalin Page 107-116 Hard Edit.pdf 3 Page 107-116 Hard Edit.pdf 4 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanthyroidstainedwithThyroglobulinantibody(RP059). Formalin fixed paraffin embeddedhumanthyroidstainedwithThyroglobulinantibody(Mob089). PDR041Prediluted 6ml RP059-05Concentrated 0.5ml Status:Regulatory IV Catalog No.: RP059Concentrated 1ml hrgoui Thyroglo ulin Polyclonal Anti-Human Rabbit thyroid. Specificity: Cellular Localization: Cytoplasmic Positive Control: Thyroid Immunogen: Mob089-05Concentrated 0.5ml Status:Regulatory IV Catalog No.: Mob089Concentrated 1ml Clone: hrgoui Thyroglo ulin Monoclonal MouseAnti-Human Immunogen: stains cells in normal, hyperplastic and neoplastic thyroids. Specificity: Cellular Localization: Cytoplasm Positive Control: Thyroid Isotype: ------DAK-Tg6 IgG2a,kappa This antibody reacts with a 300 kDa protein in immunoblotting. It It immunoblotting. in protein kDa 300 a with reacts antibody This This antibody reacts with human thyroglobulin-containing cells in cells thyroglobulin-containing human with reacts antibody This Thyroglobulin isolatedfrom humanthyroid glands. BALB/Cmicewere withpurifiedhumanthyroglobulin. injected F F , ,
P P 110 Formalin fixed paraffin embeddedhumanthyroidstainedwithThyroidPeroxidase antibody(Mob418). Formalin fixed(Mob285). paraffin embeddedlungadenocarcinoma stainedwithTTF-1 and malignant thyroid tumors. affinity for anti-TPO. This antibody may aid in the differentiation between benign synthesis. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower of thyroid follicular cells. TPO is the primary enzyme involved in thyroid hormone containing a heme prosthetic group. It is present as a dimer on the apical surface Specificity: Cellular Localization: Cytoplasmic Positive Control: Thyroid Isotype: microsomes by immunoaffinity chromatography. ua tyod eoiae hP) uiid rm thyroid from purified (hTPO) peroxidase thyroid Human Immunogen: Mob418-05Concentrated 0.5ml Status:Regulatory IV Catalog No.: Mob418Concentrated 1ml Clone: Thyroid Peroxidase Monoclonal MouseAnti-Human carcinoma but does not stain colon and breast carcinoma. thyroid gland and lung. the TTF-1 stains of primary lung cells adenocarcinoma and epithelial small cell in expressed is TTF-1 (TTF-1). factor transcription thyroid Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: Status:Regulatory IV D141M rdltd1m PDM104-10MMPrediluted 10ml PDM104Prediluted 6ml Mob285-05Concentrated 0.5ml Catalog No.: Mob285Concentrated 1ml Clone: pteil re pithelial arker Lung and Thyroid (TTF-1), Factor-1 Transcription Thyroid Monoclonal MouseAnti-Human ------MoAb47 8G7G3/1 IgG1 IgG1 This antibody is specific to a 40 kDa protein, which is identified as identified is which protein, kDa 40 a to specific is antibody This hri prxds (P) s tasebae rti o 107kDa of protein transmembrane a is (TPO) peroxidase Thyroid BALB/C mice were injected with a recombinant rat protein. Lung Nuclear 3 60 F F , , P P 2/17/17 5:08PM Primary Antibodies 2/17/17 5:08 PM NEW www.dbiosys.com P
, P F , F 3 6 0 Cytoplasmic and extracellular (secreted) extracellular and Cytoplasmic Histiocytoma, colon, pancreas colon, Histiocytoma, (Tumor Necrosis Factor alpha) Factor Necrosis (Tumor Recombinant full-length human TNF-alpha protein. TNF-alpha human full-length Recombinant Lysate of the human histiocytic lymphoma cell line U-937. Lysate This MAb recognizes human 17-26kDa protein, which is identified as identified is which protein, 17-26kDa human recognizes MAb This This antibody is specific to the alpha form of DNA topoisomerase II. It II. topoisomerase DNA of form alpha the to specific is antibody This IgM, kappa IgM, IgG2A, kappa Ki-S1 DBM15.28 ------Monoclonal Mouse Anti-Human II alpha Topoisomerase Immunogen: Isotype: Tonsil Control: Positive Nuclear Localization: Cellular Specificity: small staining in useful is antibody This cells. immunoreactive of nuclei the stains carcinoma. breast and carcinoma lung cell non-small cancer, lung cell Clone: 1ml Mob243-1 Concentrated No.: Catalog IV Regulatory Status: 0.5ml Mob243-1-05 Concentrated Immunogen: Isotype: Control: Positive Localization: Cellular Specificity: 157 a is TNF-α human Monomeric Factor-alpha). Necrosis (Tumor TNF-α cytokine amino acid protein (non-glycosylated) with a reported molecular weight of 17 kDa and can be expressed as a precursor form called free TNF-α transmembrane can be expressed molecule, as a cell surface also TNF-α is generated as type II a polypeptide consisting of a 233 is amino It acid system. residues molecular immune weight the 26 of component cell-signaling important an is TNF-α kDa. protein secreted by LPS stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF-α Complex. is Related currently AIDS being and evaluated cancers certainin of treatment Monoclonal Mouse Anti-Human Monoclonal TNF alpha Clone: 1ml Mob502 Concentrated No.: Catalog IV Regulatory Status: 6ml PDM230 Prediluted 10ml PDM230-10MM Prediluted Formalin fixed paraffin embedded human tonsil stained with Topoisomerase II alpha (Mob243-1). embedded human tonsil stained with Topoisomerase paraffin fixed Formalin Formalin fixed paraffin embedded human breast carcinoma stained with TNF alpha (Mob502). embedded human breast carcinoma paraffin fixed Formalin 111 P P
, , F (Only for markets outside the U.S. For U.S. market, see index III.) see index market, U.S. For outside the U.S. markets for (Only (Only for markets outside the U.S. For U.S. market, see index III.) index see market, U.S. For outside the U.S. markets for (Only F IV IV BALB/C mice were injected with a synthetic peptide from the N- A synthetic peptide derived from the C-terminus region of the This antibody is specific to 21 TIMP-1 kDa protein knownTIMP-2. as This antibody reacts with a 23kDa protein, known as TIMP-3. TIMP IgG2a, kappa 3A4 ------Immunogen: TIMP-2. human of region terminal Isotype: carcinoma Colon Control: Positive Cytoplasmic Localization: Cellular Specificity: and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family. TIMP are of are TIMP family. metalloproteinase matrix of enzymes inhibitory are TIMP-2 and shows TIMP-2 integrity. tissue connective of maintenance the in importance great the highest binding affinity to (MMP- both the collagenase latent IV (pro) and type active kDa forms of 92 72 of kDa form active and (MMP-2) collagenase IV Type TIMP inhibit 9). the of invasiveness proteolytic tumor cells and normal placental cells. trophoblast Polyclonal Rabbit Anti-Human Polyclonal TI P- 1ml RP072 Concentrated No.: Catalog Regulatory Status: 0.5ml RP072-05 Concentrated Immunogen: TIMP-3. human carcinoma Breast Control: Positive Cytoplasmic Localization: Cellular Specificity: form form tight inhibitory complexes with MMP, which are involved in matrix degradation degradation and in tumor invasiveness and metastasis. TIMP inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. trophoblast placental normal and cells tumor of invasiveness proteolytic Monoclonal Mouse Anti-Human Monoclonal TI P- Clone: 1ml Mob318 Concentrated No.: Catalog Regulatory Status: 0.5ml Mob318-05 Concentrated Formalin fixed paraffin embedded human pancreas stained with TIMP2 antibody (Mob318). paraffin fixed Formalin Formalin fixed paraffin embedded human placenta stained with TIMP-3 (RP072). with TIMP-3 stained embedded human placenta paraffin fixed Formalin Page 107-116 Hard Edit.pdf 5 Page 107-116 Hard Edit.pdf 6 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumantonsilstainedwithTopoisomerase II(Mob511). Formalin fixed paraffin embeddedhumanliverstainedwithTransferrin antibody(RP061). hoooe odnain Tpioeae I i as ipiae i drug in of implicated mediator also primary is the α resistance be of II tumor cells. to Topoisomerase believed is condensation. it chromosome where phases, G2-M in peak Specificity: Cellular Localization: Positive Control: Isotype: Immunogen: PDM246-10MMPrediluted 10ml PDM246Prediluted 6ml Status:Regulatory IV Catalog No.: Mob511Concentrated 1ml Clone: Topoisomerase II Monoclonal MouseAnti-Human fetal liver, epithelial cells of colon adenocarcinoma, and cells of normal liver. Specificity: Cellular Localization: Cytoplasmic Positive Control: Liver Immunogen: RP061-05Concentrated 0.5ml Status:Regulatory IV Catalog No.: RP061Concentrated 1ml Transferrin Polyclonal Anti-Human Rabbit ------DBM15.37 gG2b, kappa This antibody reacts with human transferrin. It stains hepatocytes in Topo IIαisexpressed inproliferating cellsinlateSphase, andwitha Transferrin isolatedfrom humanplasma. Recombinant human Topoisomerase II α fragment (aa1352-1493). Tonsil, colon Nuclear F 3 60 F , ,
P P NEW 112 (RP148). Formalin fixed paraffin embeddedhumaninvasive breastcarcinoma stainedwithTGFβ3 antibody Formalin fixed paraffin embeddedbreastcarcinoma stainedwith Transglutaminase IIantibody(Mob353). amounts of tissue transglutaminase. varying express types cell and tissue Different chains. polypeptide between or translational modification of proteins by formation of an isopeptide bond within rnguaiae I Tae I. Gs I ctlzs acu-eedn post- calcium-dependent catalyzes II TGase II). (TGase II transglutaminase Specificity: Specificity: Cellular Localization: Cytoplasmic, cellmembrane, matrix extracellular Positive Control: Breast carcinoma Isotype: transglutaminase. antibody does not cross-react with TGFβ1 or TGFβ2. polypeptide that remains associated with the latent portion of the molecule. This precursor proteins that are similar.very Each is cleaved to yield a 112 amino acid Immunogen: Immunogen: Mob353-05Concentrated 0.5ml Status:Regulatory IV Catalog No.: Mob353Concentrated 1ml Clone: rnguaiaeI Transglutaminase II Monoclonal MouseAnti-Human dniid n aml. Gβ, Gβ ad Gβ ae ah yteie as synthesized each are TGFβ3 and TGFβ2 TGFβ1, mammals. in identified been havedevelopment.Three TGFβ embryonic during occur that interactions RP148-05Concentrated 0.5ml Status:Regulatory Catalog No.: RP148Concentrated 1ml Specificity: Specificity: Cellular Localization: Cytoplasmic Positive Control: Placenta form ofhuman TGFβ3 protein. Immunogen: Transforming ro th Factor β (T Fβ ) Polyclonal Anti-Human Rabbit ------CUB7402 IgG1 rnfrig rwh atr (Gβ mdae ay cell-cell many mediate (TGFβ) β factor growth Transforming Asyntheticpeptidederived from theC-terminalofprecursor hs nioy ecs ih 7-5 D poen nw as known protein kDa 77-85 a with reacts antibody This ABC ie ee netd ih uiid una i liver pig guinea purified with injected were mice BALB/C IV (Only for markets outsidetheU.S. For U.S. market, seeindex III.) F , P F , P 2/17/17 5:08PM Monoclonal Mouse Anti-Human Monoclonal Mouse Anti-Human Tu ulin-α F, P Vascular ndothelial ro th Factor (V F) F, P Clone: DM1A Clone: VG1 Catalog No.: Mob286 Concentrated 1ml Catalog No.: Mob308 Concentrated 1ml Mob286-05 Concentrated 0.5ml Mob308-05 Concentrated 0.5ml PDM165 Prediluted 6ml Regulatory Status: IV PDM165-10MM Prediluted 10ml 3 6 0
Regulatory Status: IV
Formalin fixed paraffin embedded human lung stained with Tubulin-α antibody (Mob286). Immunogen: BALB/C mice were immunized with native chick brain microtubules. Formalin fixed paraffin embedded human kidney stained with VEGF antibody (Mob308). Isotype: IgG1, kappa Immunogen: BALB/C mice were injected with a recombinant VEGF protein. Positive Control: Lung Isotype: IgG1, kappa Cellular localization: Cytoplasmic Positive Control: Angiosarcoma Specificity: This antibody is specific to a 57 kDa protein identified as tubulin-α. Cellular Localization: Cytoplasmic, cell membrane, extracellular matrix This antibody does not cross-react with tubulin-β. Its epitope maps between Specificity: This antibody is specific to a cluster of proteins between 19-22 kDa amino acids 426-450. (reduced). VEGF is a homodimeric disulfide-linked glycoprotein involved in
angiogenesis, which promotes tumor progression and metastasis. It exhibits Antibodies Primary ------potent mitogenic and permeability-inducing properties specific for the vascular endothelium. Monoclonal Mouse Anti-Human Tyrosinase, elanoma arker F, P ------Clone: T311 Catalog No.: Mob290 Concentrated 1ml Polyclonal Rabbit Anti-Human Mob290-05 Concentrated 0.5ml Vascular ndothelial ro th Factor (V F) F, P PDM150 Prediluted 6ml Catalog No.: RP121 Concentrated 1ml PDM150-10MM Prediluted 10ml 3 6 0 RP121-05 Concentrated 0.5ml
Regulatory Status: IV Regulatory Status: IV
Formalin fixed paraffin embedded human melanoma stained with Tyrosinase antibody (Mob290). Formalin fixed paraffin embedded human kidney stained with VEGF antibody (RP121). Immunogen: BALB/C mice were injected with a recombinant tyrosinase protein. Immunogen: A synthetic peptide from N-terminus of human VEGF. Isotype: IgG2a Positive Control: Angiosarcoma Positive Control: Melanoma Cellular Localization: Cytoplasmic, cell membrane, extracellular matrix Cellular Localization: Cytoplasmic Specificity: This antibody reacts with a 19-22 kDa (reduced) protein. Vascular Specificity: This antibody is specific to a cluster of proteins between 70-80 kDa endothelial growth factor (VEGF) is a homodimeric, disulfide-linked glycoprotein known as tyrosinase. This antibody does not show any cross-reaction with MAGE- involved in angiogenesis which promotes tumor progression and metastasis. This 1 and tyrosinase-related protein-1, TRP-1/gp75. Staining of melanomas with this antibody reacts with 165, 189 and 121 amino acid splice variants of human VEGF. antibody showed tyrosinase in melanotic as well as amelanotic variants.
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Page 107-116 Hard Edit.pdf 7 2/17/17 5:08 PM Page 107-116 Hard Edit.pdf 8 Primary Antibodies www.dbiosys.com Formalin fixed paraffin embeddedhumanintestinestainedwithVillin(Mob518). Formalin fixed paraffin embeddedhumankidneystainedwithVEGFantibody(RMPD021). sfl n dniyn mlgat el fo piay n mtsai colorectal metastatic and primary carcinomas. from This antibody also cells labels Merkel malignant cells is of identifying the villin skin. to in Antibody useful origin. colorectal of tumors in expressed predominantly PDM253-10MMPrediluted 10ml PDM253Prediluted 6ml Status:Regulatory IVD Catalog No.: Mob518Concentrated 1ml Clone: uoa eihlu ad rgntl rc. mn nolss vli is villin neoplasms, Among tract. urogenital and epithelium mucosal iln Villin Monoclonal MouseAnti-Human Specificity: Specificity: Cellular Localization: Cytoplasmic, cellsurface Positive Control: Intestine Isotype: (aa179-311). Immunogen: Immunogen: RMPD021-10RMPrediluted 10ml Status:Regulatory IVD Catalog No.: RMPD021Prediluted 6ml Clone: VEGF. human of variants splice acid amino 121 and 189 165, the with reacts antibody involved in angiogenesis which promotes tumor progression and metastasis. This Specificity: This VEGF antibody is a homodimeric, disulfide-linked glycoprotein Cellular Localization: Cytoplasmic, cell surface Positive Control: Angiosarcoma Isotype: aclrEdteilGot atr(EF Vascular EndothelialGrowth Factor (VEGF) Anti-Human Monoclonal Rabbit ------DBM15.44 SP28 IgG IgG1, kappa niVli lbl te rs bre ae i te gastrointestinal the in area border brush the labels Anti-Villin Asyntheticpeptidefrom N-terminusofhuman VEGF protein. Recombinant human Villin fragmentof133aminoacidresidues F 3 60 3 60 ,/
P H F ,/ P H NEW 114 Formalin fixed paraffin embeddedhumantonsilstainedwithVimentinantibody(PDM029). Formalin fixed paraffin embeddedhumantonsilstainedwithVimentinantibody(RMAB019). interspecies cross-reactivity. broad a shows However,proteins.it filament intermediate other with reactivity present in the cells of mesenchymal origin. The antibody does not show any cross- Specificity: Cellular Localization: Cytoplasm Positive Control: Sarcoma, tonsil Isotype: Immunogen: Immunogen: the differential diagnosis of undifferentiated neoplasms. intermediate filament protein in mesenchymal cells and is therefore of value in value of therefore is and cells mesenchymal in protein filament intermediate Status:Regulatory IVD Ti atbd rcgie vmni. ietn s h main the is Vimentin vimentin. recognizes antibody This Specificity: Cellular Localization: Cytoplasmic Positive Control: Sarcomas Isotype: Immunogen: RMPD019-10RMPrediluted 10ml RMPD019Prediluted 6ml RMAB019-1 Concentrated 1ml Catalog No.: RMAB019 Concentrated 0.5ml Clone: ietn Vimentin Anti-Human Monoclonal Rabbit D091M rdltd1m PDM029-10MMPrediluted 10ml PDM029Prediluted 6ml Mob090-05Concentrated 0.5ml Status:Regulatory IVD Catalog No.: Mob090Concentrated 1ml Clone: Vimentin, Porcine Monoclonal MouseAnti-Human ------SP20 V9 IgG1,kappa IgG This antibody reacts with the 57 kDa intermediate filament protein filament intermediate kDa 57 the with reacts antibody This BALB/C BALB/C mice were injected with purified vimentin from porcine eye lens. Recombinanthumanvimentinprotein. F 3 60 3 60 F ,/ ,/
P P H H 2/17/17 5:08PM Primary Antibodies 2/17/17 5:08 PM NEW www.dbiosys.com P P , , F F 3 6 0 3 6 0 Recombinant human WT1 protein. WT1 human Recombinant A recombinant protein fragment corresponding to amino acids 79- acids amino to corresponding fragment protein recombinant A Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilms' Tumor (WT1) is a gene involved in the induction of Wilms’ Mesothelioma Control: IgG1, kappa IgG1, Nuclear Localization: Rabbit IgG DBM15.18 EP122 ------Monoclonal Mouse Anti-Human 1) Tumor (Wilm’s Wt1 Clone: 1ml Mob479 Concentrated No.: Catalog 6ml PDM218 Prediluted 10ml PDM218-10MM Prediluted Immunogen: Isotype: Positive Cellular Specificity: Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the length full- WT1 and also identifies WT1 lacking exon 2-encoded amino acids, Regulatory Status: IV Regulatory Status: freuently Āfound in subsets of sporadic Wilm’s tumors. The WT1 gene is normally is WT1gene The tumors. Wilm’s sporadic of subsets in Āfound freuently expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 protein has been has protein WT1 mesothelioma. and tumor Wilm’s for marker a as suggested identified in proliferative mesothelial cells, malignant mesothelioma, carcinoma, ovarian gonadoblastoma, nephroblastoma, and desmoplastic small round cell Lung tumor. adenocarcinomas rarely stain positive with this WT1 antibody. protein expression in mesothelial cells has become mesotheliomas. of a diagnosis reliable marker for the Formalin fixed paraffin embedded human mesothelioma stained with WT1 paraffin fixed (Mob479). Formalin Immunogen: immunogen. an as used was Tumor Wilm’s human of 249 Isotype: tumor Wilm’s Mesothelioma and Control: Positive Nuclear Localization: Cellular Specificity: a tumor, pediatric renal malignancy that is associated with mutations of WT1, a zinc-finger transcription factor that is essential metanephric for kidney the and development the of urogenital the expressed system. in The fetal WT1 kidney gene and is mesothelium normally and its expression has been Monoclonal RabbitMonoclonal Anti-Human (WT1) 1 Protein Tumor Wilm’s Clone: 0.5ml Concentrated RMAB070 No.: Catalog IV Regulatory Status: 1ml Concentrated RMAB070-1 6ml RMPD070 Prediluted 10ml RMPD070-10RM Prediluted mesothelioma. and tumor Wilms’ for marker a as suggested Formalin fixed paraffin embedded Wilm’s tumor stained with WT1 (RMAB070). antibody embedded Wilm’s paraffin fixed Formalin 115 NEW P P , , F F 3 6 0 Nuclear and Cytoplasmic and Nuclear Wilm’s tumor, mesothelioma tumor, Wilm’s Recombinant human WT1 protein. WT1 human Recombinant BALB/C mice were injected with truncated human WT1 protein WT1 human truncated with injected were mice BALB/C Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilms Wilms tumor-1 (WT-1), is a gene in involved the induction of Wilms Rabbit IgG Rabbit IgG1 6F-H2 DBR16.9 ------Immunogen: 1-181. acids amino N-terminal to corresponding Isotype: tumor Wilm’s Control: Positive Nuclear and/or cytoplasmic Localization: Cellular Specificity: of mutations with associated is tumor Wilms malignancy. renal pediatric a tumor, the of development the for essential is that factor transcription zincfinger WT1,a metanephric kidney and the urogenital expressed system. in The fetal WT1 kidney gene and is mesothelium, normally and its expression has been Monoclonal Mouse Anti-Human (WT1) 1 Protein Tumor Wilm’s suggested as a marker for Wilms tumor and mesothelioma. and tumor Wilms for marker a as suggested Clone: 1ml Mob437 Concentrated No.: Catalog IV Regulatory Status: 0.5ml Concentrated Mob437-05 6ml Prediluted PDM177 Specificity: Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full- Cellular Localization: Localization: Cellular Immunogen: Isotype: Control: Positive Monoclonal RabbitMonoclonal Anti-Human 1 (WT1) Tumor Wilm's length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, Regulatory Status: IV Regulatory Status: Clone: 0.5ml Concentrated RMAB094 No.: Catalog 1ml Concentrated RMAB094-1 6ml RMPD094 Prediluted 10ml RMPD094-10RM Prediluted freuently Āfound in subsets of sporadic Wilm’s tumors. The WT1 gene is normally is WT1gene The tumors. Wilm’s sporadic of subsets in Āfound freuently expressed expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 protein has been has protein WT1 mesothelioma. and tumor Wilm’s for marker a as suggested identified in proliferative mesothelial cells, malignant mesothelioma, carcinoma, ovarian gonadoblastoma, nephroblastoma, and desmoplastic small round cell Lung tumor. adenocarcinomas rarely stain positive with this WT1 antibody. protein protein expression in mesothelial cells has become mesotheliomas. of a diagnosis reliable marker for the Formalin fixed paraffin embedded Wilm’s tumor stained with WT1 antibody (Mob437). embedded Wilm’s paraffin fixed Formalin Formalin fixed paraffin embedded human Wilm's tumor stained with WT1 (RMAB094). embedded human Wilm's paraffin fixed Formalin Page 107-116 Hard Edit.pdf 9 Page 107-116 Hard Edit.pdf 10 Primary Antibodies dbiosys com Formalin fixed paraffin embeddedhumantestisstainedwithXRCC1 antibody(Mob325). testis RCC1 is C- the through III ligase DNA terminal 96 amino to acids and to binds DNA polymerase β RCC1 through the N-terminal irradiation. half. In ionizing after DNA C1) protein plays a role in excision repair of repair excision in role a plays protein ( RCC1) 1 complementing cross repair Specificity: Cellular Positive Isotype: Mob325-05Concentrated 0.5ml Status:Regulatory Catalog No.: Mob325Concentrated 1ml Clone: Immunogen: XRCC1 Monoclonal MouseAnti-Human ------33-2-5 Localization: Nuclear Control: Testis IgG2b 1 -ray This antibody is specific to an 85 kDa protein known as RCC1. . BALB/C mice were injected with recombinant RCC1 human protein. expressed at high levels. IVD So tions nno ati e ig a ity andA ordab e Diagnostic BioSystemsPrimary Antibodies ( nly for markets outsidethe .S. For .S. market, seeindex III.) Visit usat: www.dbiosys.com/primary-antibodies F ,/ P H 116 Formalin fixed paraffin embeddedhumantonsilstainedwithZAP70(Mob480). Ig-unmutated CLL cases have been shown to have a poorer anti-AP70 Āpositive courses.The prognosis.clinical divergent with groups patient identify (anti- Ig-mutated can and AP70 Ānegative)(anti-AP70 Āpositive) Ig-unmutated subtypes and CLL the between distinction the for marker surrogate excellent an is Anti-AP70 Āexpression well. as cases (CLL) leukemia lymphocytic chronic cells. AP70proteinisexpressedkiller inleukemiccellsofapproximately 25ofĀ Status:Regulatory IVD PDM221-10MMPrediluted 10ml Specificity: Cellular Positive Isotype: Immunogen: PDM221Prediluted 6ml Catalog No.: Mob480Concentrated 1ml Clone: A7 AP7 Monoclonal MouseAnti-Human DBM15.11 Localization: Cytoplasmic IgG2a, kappa Control: Tonsil, lymph node AP70 Āis a 70kDa protein tyrosine kinase found in T-cells and natural Recombinant full-length human AP70 Āprotein. 3 60 F ,/ P H NEW 2/17/17 5:08PM FITC Conjugated Antibodies 2/17/17 5:09 PM www.dbiosys.com y and ow cytometry. Pool Pool of human Lambda light chain isolated from the urine of IgA isolated from human serum. IgA isolated from IgG isolated from human serum. IgG isolated from IgM isolated from the serum of a patient with Waldenstorm’s Pool of human kappa light chain isolated from the urine of patients of urine the from isolated chain light kappa human of Pool This antibody reacts with the alpha chain of human IgA. Traces of This antibody reacts with the gamma chain of human IgG. Traces of Traces with the gamma chain of human IgG. This antibody reacts This antibody reacts with the Mu chain of human IgM. Traces of Traces of contaminating antibodies have been removed by solid Traces of contaminating antibodies have been removed by solid ------Rabbit Anti-Human Antibody IgA (alpha chain) FITC-Conjugated F007 No.: Catalog IVD Regulatory Status: Immunogen: Speci city: contaminating antibodies have but been staining removed by section solid tissue phase for absorption suited with well is antibody This proteins. plasma human applications. other for used be also may Rabbit Anti-Human IgG (Gamma chain) FITC-Conjugated Antibody chain) FITC-Conjugated IgG (Gamma Catalog No.: F008 No.: Catalog IVD Regulatory Status: Immunogen: Speci city: contaminating antibodies have but been staining removed by section solid tissue phase for absorption suited with well is antibody This proteins. plasma human applications. other for used be also may Rabbit Anti-Human IgM (Mu chain) FITC-Conjugated Antibody IgM (Mu chain) FITC-Conjugated F009 No.: Catalog IVD Regulatory Status: Immunogen: macroglobulinaemia. Speci city: contaminating antibodies have but been staining removed by section solid tissue phase for absorption suited with well is antibody This proteins. plasma human applications. other for used be also may Rabbit Anti-Human Kappa Light Chain FITC-Conjugated Antibody Chain FITC-Conjugated Kappa Light F001 No.: Catalog IVD Regulatory Status: Immunogen: Proteinuria. Jones Bence with Speci city: phase absorption. Only the kappa precipitation line appeared in cross immunoelectrophoresis. immunoelectrophoresis. This antibody is well suited for tissue section staining applications. other for used be may but Rabbit Anti-Human Lambda Light Chain FITC-Conjugated Antibody Lambda Light Chain FITC-Conjugated F002 No.: Catalog IVD Regulatory Status: Immunogen: patients with Bence Jones Proteinuria. Jones Bence with patients Speci city: phase absorption. Only the lambda precipitation line appeared in cross immunoelectrophoresis. immunoelectrophoresis. This antibody is well suited for tissue section staining applications. other for used be also may but 117 escence microscop , uorescence escein isothiocynate (FITC) conjugated antibodies. Fluorescent dye-conjugated can be antibodies Fluorescent antibodies. conjugated isothiocynateers uorescein (FITC) y: This antibody reacts with human C4, C4b, and C4c but does not does but C4c and C4b, C4, human with reacts antibody This y: C4c Complement isolated from complement-activated human C3c Complement isolated from complement-activated human complement-activated isolated from C3c Complement Fibrinogen isolated from human plasma. isolated from Fibrinogen C1q isolated from the normal human serum. C1q isolated from This antibody reacts with the human C1q complement. Traces of This antibody reacts with the human C3c complement and the C3c This antibody reacts with native brinogen Āand with brinogen Ā Speci cit Rabbit Anti-Human Antibody FITC-Conjugated C1q Complement Catalog No.: F010 No.: Catalog IVD Regulatory Status: Immunogen: Speci city: contaminating antibodies have been but removed staining by section solid tissue phase for absorption suited with well is antibody This proteins. plasma human applications. other for used be also may Rabbit Anti-Human C3c Complement FITC-Conjugated Antibody FITC-Conjugated C3c Complement Catalog No.: F003 No.: Catalog IVD Regulatory Status: Immunogen: serum. Speci city: part of C3 and C3b. It may cross react with the C3c complement from cat, cow, dog, goat, guinea pig, kangaroo, mink, mouse, rat, sheep, and swine. Traces of contaminating antibodies have been but removed staining by section solid tissue phase for absorption suited with well is antibody This proteins. plasma human applications. other for used also be may Rabbit Anti-Human C4c Complement FITC-Conjugated Antibody FITC-Conjugated C4c Complement F005 No.: Catalog IVD Regulatory Status: Immunogen: serum react with is the antibody This C4d proteins. plasma human with epitope. absorption phase solid Traces by removed applications. of other for contaminating used be also antibodies may but staining have section tissue been for suited well Rabbit Anti-Human Fibrinogen FITC-Conjugated Antibody FITC-Conjugated Fibrinogen F006 No.: Catalog IVD Regulatory Status: Immunogen: Speci city: removed been have antibodies contaminating of Traces Y. and X, E, D, fragments by solid applications. other phase for absorption used with be also human may plasma but staining proteins. sectionThis tissue antibody for is suited well ------Diagnostic BioSystems off BioSystems Diagnostic used in a varietyas immunohistochemistry of applications such I C Con ugated Antibodies Con ugated I C Diagnostic BioSystems Diagnostic Page 117-135 Hard Edit.pdf 1 Page 117-135 Hard Edit.pdf 2 Detection Systems www.dbiosys.com Diagnostic BioSystems Detection Sys tems Detection P POLYMER DETECTION SYSTEM UNOVUE PLUS™ ONE STEP DETECTION SYSTEMS POLYVUE PLUS™ SYSTEM STEPDETECTION TWO Str r ebae hs bod pcrm egns ffr ovnec we promn imnhsohmsr wt a ie ag of range wide a with immunohistochemistry antibodies. performing when convenience offer reagents spectrum broad These membrane. or PolyVue Plus reagents yield consistent and reproducible antibody detection, regardless of cellular antigen location: enables nuclear, superior cytoplasmic detection of antibodies at a lower concentration. Diagnostic BioSystems offers two types of IHC Detection Systems: visualized by a variety of methods. The method is based on the use of a antibody primary that specically Ābinds to its complimentary antigen. The bound antigen may be Immunohistochemistry is a highly sensitive method that allows the localization of antigens within a cell or a tissue with high resolution. suited for multiplex multicolor immunohistochemical wellstaining are assays. kits detection Plus Species-specic ĀUnoVue background. signicantly Ālower with conjugates avidin/streptavidin and biotin step detection yielding higher sensitivity while maintaining the extremely clean background. The enhanced sensitivity of PolyVue Plus two- for immunoglobulins anti-mouse and anti-rabbit enzyme-linked polymeric the with reagentenhancer PolyVue an employsPlus systems are suitablefor demonstratingantigensinf Diagnostic BioSystems offers systems ofpolymer-baseddetection two types for biotin-free immunohistochemistry. These detection UnoVue Plus uses anti-rabbit and anti-mouse immunoglobulins, directly labeled with enzymes using a proprietary hyperlabelling proprietary a using technology. UnoVue Plus is enzymes a detection one-step system, enabling faster with staining procedures than traditional labeled two-step methods using directly immunoglobulins, anti-mouse and anti-rabbit uses Plus UnoVue olyme epta v r Detr idin Biotin idin ection Sys ection Detection System tem ed paraffin embedded tissues and cryostat sections. ormalin- xed paraffinembeddedtissuesandcryostat 118 2/17/17 5:09PM Detection Systems 2/17/17 5:09 PM www.dbiosys.com 3 igh speci city High sensitivity H Clean background staining Highly reproducible stainers as automated manual as well Suitable for Shorter detection reagents incubation times for ADVANTAGES OVER ADVANTAGES DETECTION S STEMS: CONVENTIONAL Poly ue Plus 2 119 1 1. Human lung squamous cell carcinoma stained with Cytokeratin AE3 (PDM044) using PolyVue Plus Two Step Detection Step System. Two Plus AE3 (PDM044) using PolyVue stained with Cytokeratin carcinoma 1. Human lung squamous cell Detection Step System. Two Plus A (RMPD105) using PolyVue stained with Chromogranin 2. Human pancreas Detection Step System. Two Plus (PDM257) using PolyVue stained with PAX-8 carcinoma cell 3. Human renal HIGHLY SENSITIVE. EXCEPTIONAL DETECTION SYSTEM. EXCEPTIONAL SENSITIVE. HIGHLY Human lung squamous cell carcinoma stained with Cytokeratin AE1 (PDM072) using PolyVue Plus PolyVue AE1 (PDM072) using stained with Cytokeratin carcinoma Human lung squamous cell System. Step Detection Two Diagnostic BioSystems’ PolyVue Plus is a highly biotin-free immunostaining PolyVue sensitive, detection to simultaneously formulated system Diagnostic BioSystems’ detect mouse as well as rabbit antibodies. PolyVue Plus employs an enhancer reagent with the polymeric enzyme-linked anti-rabbit and anti-rabbit enzyme-linked polymeric the with reagent enhancer an employs Plus PolyVue antibodies. rabbit as well as mouse detect signals. weaker or anti-mouse immunoglobulins concentration for two-step detection, lower yielding higher at sensitivity while maintaining antibodies the extremely of clean background. detection superior enables Plus PolyVue of sensitivity enhanced The Poly ue Plus Poly ue Page 117-135 Hard Edit.pdf 3 Page 117-135 Hard Edit.pdf 4 Detection Systems www.dbiosys.com Two StepDetectionSystem PolyVue Plus Diagnostic BioSystems difference. Vibrant, high quality cell staining for sharper IHC results. our Our Clean. Solution. Innovation. Crisp. Clear.. Diagnostic BioSystems is committed to improving immunohistochemistry staining one slide at a time. Experience the Chromogen, and an empty mixing bottle for Stable DAB/Plus. os/abt oyu HP ae, tbe A/ls ue, tbe DAB/Plus Stable Buffer, DAB/Plus Stable label, HRP PolyVue Mouse/Rabbit ------i Contents: Kit savings savings due to less hazardous waste generation. solution of Stable DAB/Plus is stable for a week, offering convenience and cost cost and convenience offering week, a for stable is DAB/Plus Stable of solution be used for manual staining or with any automated staining platform. The working working platform. The staining automated any with or staining manual for used be IgM and rabbit primary antibodies, both monoclonal and polyclonal. Reagents can can Reagents polyclonal. and monoclonal both antibodies, primary rabbit and IgM antibodies antibodies raised in mouse and rabbit, simultaneously. This kit can detect mouse IgG, than biotin/avidin detection systems. These reagents work equally well with with well equally work reagents These systems. detection biotin/avidin than tly lower background background lower signi cantly yielding polymer-based, is system detection The PV1000D1000 Tests sensitivity, high a is 2-step horseradish peroxidase-labeled detection system for immunohistochemistry. System Detection HRP/DAB Mouse/Rabbit PolyVue The Status:Regulatory IVD Catalog No.: PV100D100 Tests PolyVue HRP/DAB System Mouse/Rabbit Detection Stable DAB Buffer,Plus Plus Chromogen, DABand an Stable empty Label, mixing bottle.HRP Mouse/Rabbit Plus PolyVue Enhancer, HRP Contents: Kit background than detection systems using biotin and avidin conjugates. l lower signi cantly with tissues of types different in antigens membrane erdcbe muotiig o al ye o ncer ctpamc and cytoplasmic nuclear, of types all and for consistent immunostaining ensures reproducible This technology. hyperlabelling tandem proprietary has been developed by directly labeling immunoglobulins with enzymes using a system preparations. This cell and cytosmears, smears, blood with used be also PVP25D25 Testsembedded tissues and cryostat sections. The PolyVue Plus Detection f System in may antigens labeling for suitable system PVP100D100 detection Testsstep The PolyVue Plus Mouse/Rabbit HRP/DAB Detection System is a non-biotin, two- Status:Regulatory IVD Catalog No:PVP000D1000 Tests PolyVue HRP/DAB System PlusMouse/Rabbit Detection Tissue Primer, Background Blocker, PolyVue Plus Mouse/Rabbit Mouse/Rabbit Plus PolyVue Blocker, Background Primer, Tissue eoiae lc, oye Pntain nacr Anti- Enhancer, Penetration Polymer Block, Peroxidase ed paraffin- ormalin- xed PolyVue Plus. Available in25,100and1000testsystems. 120 Substrate Chromogen, Montage Hematoxylin. BackgroundBlocker, PolyVueMontage HRP, DABBuffer,Montage DABMontage Contents: Kit without compromising results. Montage PolyVue Plus Auto Detection System enables faster staining procedures automated staining using the DBS Montage 360. The increased sensitivity of the oolnl n plcoa. hs eeto Sse hs en eind for designed been has System Detection both antibodies, This primary polyclonal. rabbit and and monoclonal IgM IgG, mouse with use for suitable is System can simultaneously detect both mouse and rabbit antibodies. This system PolyVue Montage AutoDetection Plus sections. cryostat and tissues embedded d paraffin- formalin- xed in antigens labeling for two-step suitable non-biotin, system a is detection System Detection Auto Plus PolyVue Montage The Status:Regulatory IVD Catalog No.: PVP100-AUTO 100 Tests 360 Montage PolyVue PlusAuto System Detection
otg Tsu Pie, otg PlVe nacr Montage Enhancer, PolyVue Montage Primer, Tissue Montage 2/17/17 5:09PM no ue Plus ne Step Detection System
Quick. Consistent. Reproducible. Diagnostic BioSystems is committed to providing immunohistochemistry solutions at an affordable cost. Experience greater efficiency over a broad spectrum of antibodies.
UnoVue Plus Mouse/Rabbit AP/PermaRed Detection System UnoVue Mouse HRP/DAB Detection System Catalog No.: UVP25AR 25 Tests Catalog No.: UM100PD 100 Tests UVP100AR 100 Tests Regulatory Status: IVD UVP1000AR 1000 Tests The UnoVue Mouse HRP/DAB Detection System is a polymer-based 1-step Regulatory Status: IVD horseradish peroxidase-labeled detection system for immunohistochemistry. The UnoVue Plus Mouse/Rabbit AP/PermaRed Detection System is a non-biotin, This kit can detect mouse IgG and IgM antibodies, with signicantly Ālower one-step Mouse/Rabbit polymer detection system suitable for demonstrating background than biotin/avidin detection systems. The Mouse UnoVue HRP/DAB antigens in formalin- xed paraffin-embedded tissues and cryostat sections. The Detection System can be used for manual staining or with any automated UnoVue Plus Detection System may also be used with blood smears, cytosmears, staining instrument. The working solution of Stable DAB/Plus is stable for a week, and cell preparations. offering convenience and cost savings due to less hazardous waste generation. Kit Contents: Anti-Mouse/Rabbit AP Polymer, PermaRed AutoPlus Buffer, and This species-specic Ādetection system is particularly useful for multiplex PermaRed AutoPlus Chromogen. immunohistochemical staining assays. Kit Contents: Peroxidase Block, Anti-Mouse HRP Polymer, Stable DAB/Plus Buffer, ------Stable DAB/Plus Chromogen, and an empty mixing bottle for Stable DAB/Plus. Montage UnoVue Plus Auto Detection System ------Catalog No.: UVP100-AUTO 100 Tests 3 6 0 Regulatory Status: IVD UnoVue Mouse on Mouse (MOM) HRP/DAB Detection System The Montage UnoVue Plus Auto Detection System is a non-biotin, one-step Catalog No.: MMU25PD 25 Tests Mouse/ Rabbit polymer detection system suitable for demonstrating antigens in MMU100PD 100 Tests formalin xed paraffin-embedded tissues and cryostat sections. The Montage Regulatory Status: IVD UnoVue Plus detection kits have been developed by directly labeling anti-mouse The UnoVue Mouse on Mouse (MOM) HRP/DAB Detection System is a non-biotin, and anti-rabbit immunoglobulins with enzymes using a proprietary tandem onestep detection system suitable for detecting mouse antigens on mouse tissue hyperlabelling technology. This ensures consistent and reproducible sections. The UnoVue detection system may be used with formalin- xed paraffin immunodetection of mouse and rabbit antibodies with a single reagent. Nuclear, embedded and cryostat sections, as well as blood smears, cytosmears, and cell cytoplasmic and membrane antigens in different types of tissues can be detected preparations. readily. The single step Montage UnoVue Plus Detection System enables faster Kit Contents: Tissue Primer, Mouse on Mouse (MOM) Blocking Reagent, Mouse staining procedures than traditional two-step methods using biotin and UnoVue HRP Polymer, Stable DAB/Plus Buffer, Stable DAB/Plus Chromogen, avidin/streptavidin conjugates, with signi cantly lower background. The Empty mixing bottle for Stable DAB/Plus. Montage UnoVue Plus Auto Detection System is suitable for use with mouse rabbit IgG and IgM antibodies, both monoclonal and polyclonal. The reagents ------have been optimized to be used with the Montage 360 automated staining platform. UnoVue Mouse/Rabbit HRP/DAB Detection System Kit Contents: Montage Tissue Primer, Montage Background Blocker, Montage Catalog No.: UMR100PD 100 Tests Mouse/Rabbit AP, Montage PermaRed Auto Plus Buffer, Montage PermaRed Auto UMR1000PD 1000 Tests
Plus Chromogen, and Montage Hematoxylin. Regulatory Status: IVD SystemsDetection The UnoVue Mouse/Rabbit HRP/DAB Detection System is a polymer-based 1-step ------horseradish peroxidase-labeled detection system for immunohistochemistry. These reagents detect antibodies raised in mouse and rabbit, simultaneously, UnoVue Rabbit AP/PermaRed Detection System with signicantly Ālower background than biotin/avidin detection systems. This kit Catalog No.: UR100AR 100 Tests can detect mouse IgG, IgM and rabbit primary antibodies, both monoclonal and Regulatory Status: IVD polyclonal. Reagents can be used for manual staining or with any automated The UnoVue Rabbit AP/PermaRed Detection System is a polymer-based 1-step staining platform. The working solution of Stable DAB/Plus is stable for a week, alkaline phosphatase-labeled detection system for immunohistochemistry. This offering convenience and cost savings due to less hazardous waste generation. kit can detect rabbit antibodies, both monoclonal and polyclonal, with Kit Contents: Peroxidase Block, Anti-Mouse/Rabbit HRP Polymer, Stable signicantly Ālower background than biotin/avidin detection systems. The Rabbit DAB/Plus Buffer, Stable DAB/Plus Chromogen, and an empty mixing bottle for UnoVue AP/ PermaRed Detection System can be used for manual staining or with Stable DAB/Plus. automated instruments which can perform PermaRed substrate and chromogen mixing shortly before application to the slide. For use on automated stainers without an onboard mixing station, the anti-rabbit UnoVue AP polymer reagent can be used with our stable PermaRed/AP-Auto (refer to catalog number K049- AUTO) for walk-away convenience. This species-specic Ā detection system is particularly useful for multiplex immunohistochemical staining assays. Kit Contents: Anti-Rabbit-AP Polymer, PermaRed/AP Buffer, PermaRed/AP Chromogen, and an empty mixing bottle for PermaRed/AP.
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Page 117-135 Hard Edit.pdf 5 2/17/17 5:09 PM Page 117-135 Hard Edit.pdf 6 Detection Systems www.dbiosys.com UnoVue OneStepDetectionReagents Kit Contents: be used with blood smears, cytosmears, and cell preparations. embedded tissues and frozen sections. The UnoVue detection reagent may also mayreagent frozen sections. detection UnoVueand The tissues embedded d paraffin- MU-HRP10001000 Tests detection formalin- xed in one-step antigens non-biotin demonstrating for a suitable is reagent Reagent Detection HRP Mouse UnoVue Regulator Status: IVD Catalog No.: MU-HRP100100 Tests UnoVue Reagent MouseHRPDetection Kit Contents: be used with blood smears, cytosmears, and cell preparations. embedded tissues and cryostat sections. The UnoVue detection reagent may also d paraffin- MRU-AP10001000 Tests formalin- xed in antigens demonstrating for suitable reagent UnoVue AP Reagent Detection Mouse/Rabbit is a detection non-biotin one-step Regulator Status: IVD Catalog No.: MRU-AP100100 Tests UnoVue Reagent APDetection Mouse/Rabbit Kit Contents: smears, cytosmears, and cell preparations. and frozen sections. The UnoVue detection reagents may also be used with blood suitable for demonstrating antigens in f MU-AP10001000 Tests UnoVue Mouse AP Detection Reagent is a non-biotin one-step detection reagent Regulator Status: IVD Catalog No.: MU-AP100 100 Tests UnoVue Reagent MouseAPDetection embedded tissues and cryostat sections. f in antigens demonstrating for suitable highly are reagents detection hyperlabelling one-step technology.non-biotin tandem These proprietary a using enzymes with sections.immunoglobulins cryostat and tissues paraffin-embedded xed formalin-in antigens fordemonstrating suitable technology.hyperlabellingreagentshighly are detection one-step non-biotin These UnoVue One Step Detection Reagents are developed by directly labelling immunoglobulins with enzymes using a proprietary tandem ------UnoVue Reagent MouseHRPDetection UnoVue Mouse/Rabbit AP Detection Reagent UnoVue APDetection Mouse/Rabbit UnoVue Reagent MouseAPDetection Visit usat http://dbiosys.com/products/detection-systems staining andare available inready to useformats. ormalin- xed paraffin-embedded tissues are suitablefor manual andautomated DBS Detection SystemsDBS Detection 122 Kit Contents: smears, cytosmears, and cell preparations. and frozen sections. The UnoVue detection reagent may also be used with blood suitable for demonstrating antigens in f UnoVue Rabbit AP Detection Reagent is a non-biotin one-step detection reagent Regulator Status: IVD RU-AP10001000 Tests Catalog No.: RU-AP100100 Tests UnoVue Reagent APDetection Rabbit Kit Contents: also be used with blood smears, cytosmears, and cell preparations. embedded tissues and frozen sections. The UnoVue HRP Detection Reagent may d paraffin- MRU-HRP10001000 Tests formalin- xed in antigens demonstrating for suitable reagent UnoVue Mouse/Rabbit HRP Detection Reagent is a non-biotin one-step detection Regulator Status: IVD Catalog No.: MRU-HRP100100 Tests UnoVue Reagent HRPDetection Mouse/Rabbit ------UnoVue Rabbit AP Detection Reagent UnoVue APDetection Rabbit UnoVue Mouse/Rabbit HRP Detection Reagent UnoVue HRPDetection Mouse/Rabbit ormalin- xed paraffin-embedded tissues ed paraffin- ormalin- xed 2/17/17 5:09PM Detection Systems 2/17/17 5:09 PM www.dbiosys.com 123 * These kits do not contain any substrate/chromogen. * These kits do not contain KIT COMPONENT KIT COMPONENT Mouse Link Mouse Link VOLUME Rabbit Link Rabbit Link NO. CATALOG Mouse & Rabbit Link 10ml Mouse & Rabbit Link 100ml 10ml HRP Label 10ml 100ml HRP Label 100ml M001 M002 ALP Label M005 ALP Label M003 M006 M004 10ml 100ml 10ml 100ml M007 M008 M009 M010 KIT Mouse Rabbit Kit (AEC) Peroxidase Mouse Kit (AEC) Peroxidase RabbitKit (AEC) Peroxidase Tests 100 Tablets) Mouse Rabbit Kit (DAB Peroxidase Tests 100 Tablets) Mouse Kit (DAB Peroxidase Tablets) Rabbit Kit (DAB Peroxidase KP50A Liquid) Mouse Rabbit Kit (DAB Peroxidase KP50D Tests 100 Tests Mouse Liquid) Kit (DAB 100 Peroxidase Tests 100 Tests 100 Rabbit Liquid) Kit (DAB Peroxidase Tests 100 KP50AM Mouse Rabbit Kit ĀPeroxidase KP50L KP50DM KP50AR Mouse Kit ĀPeroxidase Tests 100 TEST SIZE KP50DR Rabbit Kit ĀPeroxidase Tests 100 Red) Mouse Rabbit KitAlk. (Fast Phos. NO. CATALOG KP50LM Tests Red) MouseAlk. Kit 1000 (Fast Phos. KP50LR Red) RabbitAlk. Kit Phos. (Fast Tests 100 Mouse Rabbit Staining KitAlk. Ā Phos. KP500 MouseAlk. Kit Staining Ā Phos. Tests 1000 KA50F RabbitAlk. Staining Kit Phos. Ā Tests 1000 Tests 1000 Tests 100 KP500M Tests 100 KA500 KP500R KA50FM Tests 1000 KA50FR Tests 1000 KA500M KA500R Ready-to-Use Kits Components Ready-to-Use Diagnostic BioSystems offers immunostaining detection systems based on streptavidin/biotin technology. We offer species-specic Ākits Ākits species-specic offer We technology. streptavidin/biotin on based systems detection immunostaining offers BioSystems Diagnostic to detect antibodies raised in rabbits or mice and convenient broad spectrum kits to detect both. DBS detection systems are available in available are systems detection DBS both. detect to kits spectrum broad convenient and mice or rabbits in raised antibodies detect to concentrated and ready-to-use formats, with the secondary antibody containing either goat anti-mouse and anti-rabbit IgG, goat anti- goat IgG, anti-rabbit and anti-mouse goat either containing antibody secondary the with formats, ready-to-use and concentrated IgG. anti-rabbit goat or IgG, mouse Streptavidin Biotin Based Detection System Detection Biotin Based Streptavidin Page 117-135 Hard Edit.pdf 7 Chromogens
New discoveries in the clinic are demanding more functionality from IHC. Diagnostic BioSystems offers novel proprietary chromogens in Brown, Red, Green, Yellow and Blue for easy to develop multistains in your own lab. Use of high-quality, novel chromogens results in robust staining, making results reproducible and trustworthy.
High Quality Staining—Detect and diagnose with con dence
Broad Applicability—Single and Multiplex IHC and ISH
Versatile and High Performance Reagents—HRP and AP compatible, well suited for manual and automation
Diagnostic BioSystems provides chromogens with two commonly used enzyme labels: Horse Radish Peroxidase (HRP) and Alkaline Phosphatase (AP).
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Page 117-135 Hard Edit.pdf 8 2/17/17 5:09 PM Chromogens 2/17/17 5:09 PM www.dbiosys.com ------PermaGreen PermaGreen Plus/AP is a substrate chromogen system phosphatase for (AP) detection use in with immunohistochemistry alkaline (IHC) or in situ hybridizations (ISH). PermaGreen Plus/AP has been modified to increase staining increase to modified been has Plus/AP PermaGreen (ISH). hybridizations producing a intensity, strong green color that is insoluble in alcohol and xylene sections substitutes; therefore in can cleared in alcohol, be a dehydrated xylene mounted. permanently and substitute, PermaBlue/AP PermaBlue/AP is a substrate chromogen system for use with alkaline PermaGreen/AP K052 Ready-to-Use 30ml No.: Catalog IVD Regulatory Status: K052-110 Ready-to-Use 110ml Plus/AP PermaGreen K059 Ready-to-Use 30ml No.: Catalog IVD Regulatory Status: K059-110 Ready-to-Use 110ml PermaBlue Plus/AP Plus/AP PermaBlue K058 Ready-to-Use 30ml No.: Catalog IVD Regulatory Status: K058-110 Ready-to-Use 110ml phosphatase phosphatase (AP) detection in immunohistochemistry (IHC) or in situ hybridizations (ISH). PermaBlue Plus/AP has stability of been the reformulatedworking solution to while producing increase a distinct bright PermaBlue blue Plus/AP color. is insoluble in alcohol sections and can xylene be dehydrated substitutes; in therefore alcohol, cleared in xylene substitute, and permanently mounted. permanently PermaGreen/AP PermaGreen/AP is a substrate chromogen system for use with alkaline phosphatase phosphatase (AP) detection in immunohistochemistry (IHC) or in situ hybridizations (ISH). PermaGreen/ AP (ISH). hybridizations a produces PermaGreen/ color green that is insoluble in alcohol and xylene substitutes (both aliphatic hydrocarbon and citrus based); therefore sections can be dehydrated in alcohol, cleared in a xylene substitute, mounted. permanently and Formalin fixed paraffin embedded human tonsil stained with HMW CK antibody (PDM074) labeled paraffin fixed Formalin a strong green color. Plus/AP Chromogen (K059) produces with PermaGreen Formalin fixed paraffin embedded human tonsil stained with HMW CK antibody (PDM074) labeled human tonsil stained with HMW CK antibody (PDM074) embedded paraffin fixed Formalin a distinct bright blue color. Plus/AP Chromogen (K058) produces with PermaBlue 125 ------BCIP/NBT Chromogen/Substrate Kit Chromogen/Substrate BCIP/NBT K006 Ready-to-Use 15ml No.: Catalog IVD Regulatory Status: DBS offers a stable, BCIP/NBT solution in ready-to-use form. It produces a blue colored end product which gives a good contrast with nuclear fast red counterstain. Specimens stained in BCIP/NBT cannot be dehydrated in ethanol and should be mounted K002). in (cat. CC/Mount an aqueous based mounting medium such as BCIP/INT Chromogen/Substrate Kit BCIP/INT Chromogen/Substrate K008 Ready-to-Use 15ml No.: Catalog IVD Regulatory Status: DBS offers a stable, BCIP/INT solution in ready-to-use form. It produces a brown colored end product which gives a good contrast with blue hematoxylin counterstain. Specimens stained in BCIP/INT cannot be dehydrated in ethanol and should be mounted K002). in (cat. CC/Mount an aqueous based mounting medium such as Fast Red TR Salt Tablets TR Salt Red Fast 20 each Tablets DMR0440T No.: Catalog IVD Regulatory Status: Fast Red tablets are used as a chromogen for alkaline phosphatase immunostaining systems. AP-based AP hydrolyses napthol phosphate esters to phenolic to salts diazonium colorless to couples phenol The phosphates. and compounds product. end colored red a produces Red Fast dye. azo colored insoluble, produce Fast Red TR Salt Tablet Kit Tablet TR Salt Red Fast Substrate 0.5ml 2.5ml, 10 each, Buffer Tablets K031 Chromogen No.: Catalog IVD Regulatory Status: This alkaline phosphatase chromogen is specimens designed do to not be require used dehydration. Fast when Red tissue is not stable during the dehydration dehydration process and should Red is Fast not with compatible stained with Tissues alcohol product. end and red-colored xylene. brilliant a Fast Red produces K002). (cat. CC/Mount as such media mounting aqueous with mounted be K051 Ready-to-Use 30ml No.: Catalog IVD Regulatory Status: PermaBlue/AP is a substrate chromogen system for use with alkaline K051-110 Ready-to-Use 110ml PermaBlue/AP phosphatase phosphatase AP) detection in immunohistochemistry (IHC) or in situ hybridizations (ISH). PermaBlue/ AP produces a vibrant blue color. PermaBlue/AP PermaBlue/AP color. blue vibrant a produces AP PermaBlue/ (ISH). hybridizations is insoluble in alcohol and xylene substitutes (both aliphatic hydrocarbon and citrus sectionsbased); in therefore can cleared in alcohol, be xylenedehydrated mounted. permanently and substitute, PermaBlue/AP-Auto 30ml K051-AUTO No.: Catalog IVD Regulatory Status: PermaBlue/AP-Auto is a substrate chromogen phosphatase system (AP) for detection use in immunohistochemistry with (IHC) alkaline or K051-AUTO-110ml in situ hybridizations (ISH) to be used on an automated staining system. staining automated an on used be to (ISH) hybridizations Chromogens for AP Chromogens Page 117-135 Hard Edit.pdf 9 PermaRed/AP (Alcohol & Xylene Compatible) Chromogens for HRP Catalog No.: K049 Ready-to-Use 30ml K049-110 Ready-to-Use 110ml Regulatory Status: IVD AEC/HRP Chromogen/Substrate Kit PermaRed/AP is a substrate chromogen system for use with alkaline phosphatase Catalog No.: K003 Concentrated 3ml (AP) detection in immunohistochemistry (IHC) or in situ hybridizations (ISH). Regulatory Status: IVD PermaRed/AP produces a brilliant dark red color. PermaRed/AP is insoluble in AEC is well accepted among pathologists because of its relatively less toxic nature organic solvents; therefore sections can be dehydrated in alcohol, cleared in compared to DAB. It produces a red colored end product which gives a good xylene (or a xylene-substitute), and permanently mounted. contrast with blue hematoxylin counter stain. Specimens stained with AEC cannot be dehydrated in ethanol and should be mounted in aqueous based mounting medium such as CC/Mount (cat. K002). ------PermaRed/AP-Auto For Use on Automated Staining Platforms DAB/HRP Chromogen/Substrate Kit Catalog No.: K049-Auto Ready-to-Use 30ml Catalog No.: K001 Tablets 20 each K049-Auto-110 Ready-to-Use 110ml Regulatory Status: IVD Regulatory Status: IVD DAB is a chromogen of choice when performing immunoperoxidase staining. It is PermaRed/AP-Auto produces a red color, ranging from pink to brilliant dark red, well accepted among pathologists because DAB is much more sensitive and gives depending on the signal intensity. It is insoluble in organic solvents; therefore cleaner background than aminoethylcarbazole (AEC). Specimens stained with sections can be dehydrated in alcohol, cleared in xylene (or a xylene-substitute), DAB can be dehydrated in ethanol, cleared in xylene and mounted for permanent record keeping. However, because of its carcinogenic nature, some labs would and permanently mounted. PermaRed/AP-Auto has been formulated for on-slide like to avoid the handling of DAB powder. To resolve this problem, we offer DAB in mixing. The instrument should be programmed to apply the substrate-buffer to tablet format to minimize the exposure of lab personnel to DAB powder. the slide followed by application of the chromogen reagent. The substrate-buffer and chromogen components are stable in their separate formats. They can be ------loaded into the reagent rack at the beginning of the staining run with the other reagents, for walk away convenience. DAB/HRP Chromogen/Substrate Kit Catalog No.: K007 Ready-to-Use 200ml ------Regulatory Status: IVD DAB is a widely used chromogen for immunoperoxidase staining and PermaRed/AP-AutoPlus immunoblotting. It has been well accepted among pathologists because DAB is more sensitive and gives cleaner background than aminoethylcarbazole (AEC). Catalog No.: K057-AutoPlus 30ml Specimens stained with DAB can be dehydrated in ethanol and cleared in xylene K057-AutoPlus 110 110ml and can be mounted for permanent record keeping. However, because of its Regulatory Status: IVD carcinogenic nature, some labs would like to avoid handling DAB powder. To resolve this problem, we offer DAB in liquid format to minimize the exposure of lab personnel to DAB powder. ------20X DAB Enhancer Catalog No.: K012 Concentrated 10ml Regulatory Status: IVD DAB is a widely used chromogen for immunoperoxidase staining and immunoblotting. DAB gives cleaner background than aminoethylcarbazole (AEC). Specimens stained in DAB can be dehydrated in ethanol and cleared in xylene and can be mounted for permanent record keeping. Strength of signal generated during the immunostaining is the key to a good staining. The reagent is a stable liquid solution which increases the staining intensity of specimens stained with DAB several-fold, thereby increasing the efficiency of detection. ------Formalin fixed paraffin embedded squamous cell carcinoma human tissue stained with CK 5/6 antibody (MOB362) labeled with PermaRed AutoPlus (K057) produces a brilliant red color. High Contrast DAB PermaRed/AP-Auto/Plus produces a red color, ranging from pink to brilliant dark Catalog No.: K055 Ready-to-Use 200ml red, depending on the signal intensity. It is insoluble in organic solvents; therefore Regulatory Status: IVD sections can be dehydrated in alcohol, cleared in xylene (or a xylene-substitute), and permanently mounted. Chromogens
perience Colorful Chromogens. Vibrant, high quality cell staining Formalin xed paraffin embedded lung adenocarcinoma human tissue stained with CD20 antibody for sharper IHC results. (PDM004) labeled with High Contrast DAB (K055) produces a dark chocolate brown color. DAB, is a widely used chromogen for immunoperoxidase staining, and is well accepted among pathologists because of its increased sensitivity and decreased Visit us at: http://dbiosys.com/products/chromogens background when compared to amino ethylcarbazole (AEC). Specimens stained with DAB can be dehydrated, cleared, and permanently mounted. High Contrast DAB is more sensitive and stable than traditional working DAB solutions.
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Page 117-135 Hard Edit.pdf 10 2/17/17 5:09 PM Intensi/Fire PermaBlack/HRP Catalog No.: K045 Ready-to-Use 15ml Catalog No.: K062 Ready to Use 30ml K062-110 Ready to Use 110ml Regulatory Status: IVD Regulatory Status: IVD
Formalin fixed paraffin embedded human tonsil stained with Cytokeratin labeled with DAB and enhanced using Intensi/Fire. Formalin fixed paraffin embedded human tonsil stained with Cytokeratin H.M.W and labeled with One of the hallmarks of successful IHC is the strength of the signal generated PermaBlack/HRP (K062). during immunostaining. DAB, widely used as a chromogen for PermaBlack/HRP is a substrate chromogen system for use with horseradish immunoperoxidase staining, has been well accepted by pathologists due to its peroxidase (HRP) detection in immunohistochemistry (IHC) or in situ superior performance compared to amino ethylcarbazole (AEC). Tissue hybridizations (ISH). PermaBlack/HRP can be permanently mounted to produce a specimens stained with DAB show increased staining intensity when Intensi/Fire sharply contrasting ebony black color that can be easily distinguished from other is applied. Only a brief incubation is required. Increased sensitivity of the stains. detection system allows the cost-effective option of diluting the primary antibody 5 to 10 fold. Intensi/Fire increases the signal intensity without creating ------background staining. ------PermaBlue/HRP Catalog No.: K063 Ready to Use 30ml K063-110 Ready to Use 110ml Mono AEC/Plus Liquid Format Regulatory Status: IVD Catalog No.: K050 Ready-to-Use 30ml K050-110 Ready-to-Use 110ml
Regulatory Status: IVD
Formalin fixed paraffin embedded human tonsil stained with Cytokeratin H.M.W and labeled with PermaBlue/HRP (K063). PermaBlue/HRP is a substrate chromogen system for use with horseradish
peroxidase (HRP) detection in immunohistochemistry (IHC) or in situ Chromogens Formalin fixed paraffin embedded human tonsil stained with high molecular weight Cytokeratin hybridizations (ISH). PermaBlue/HRP can be permanently mounted to produce a H.M.W and labeled with Mono AEC/Plus (K050). strong azure blue color that can be easily distinguished from other stains. Mono AEC/Plus is a substrate chromogen system for use with horseradish peroxidase (HRP) detection in immunohistochemistry (IHC) or in situ hybridizations (ISH). AEC produces a red colored end product, yielding strong contrast when combined with a blue hematoxylin counterstain. AEC has been well accepted among histotechnologists because it is less chemically hazardous than DAB. Specimens stained using Mono AEC/ Plus cannot be dehydrated in ethanol and must be mounted in an aqueous-based mounting medium such as CC/Mount (cat. K002).
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Page 117-135 Hard Edit.pdf 11 2/17/17 5:09 PM Page 117-135 Hard Edit.pdf 12 Chromogens www.dbiosys.com PermaRed/HRP K064-110Readyto Use110ml Status:Regulatory IVD Catalog No.: K064ReadytoUse30ml PermaRed/HRP (K064). Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin H.M.W andlabeledwith PermaYellow/HRP (K060). Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin H.M.W labeledwith K060-110ReadytoUse110ml Status:Regulatory IVD Catalog No.: K060ReadytoUse30ml PermaYello /HRP easily be distinguished from other stains. can that stain red brick distinct a produces PermaRed/HRP (ISH). hybridizations easily be distinguished from other stains. hybridizations (ISH). Perma ellow/HRP produces a distinct bright yellow that can situ in or (IHC) immunohistochemistry in detection (HRP) peroxidase emRdHP s sbtae hooe sse fr s wt horseradish with use for system chromogen substrate a is PermaRed/HRP eoiae HP dtcin n muoitceity IC o i situ in or (IHC) immunohistochemistry in detection horseradish (HRP) with peroxidase use for system chromogen substrate a is Perma ellow/HRP ------iF PDM168 PDM088 PDM011 PDM146 PDM153 MiTF S100 Melanoma Cocktail MART-1/Melan-A CODE HMB45 DBS ANTIBODIESFORDERMAPATH 128 Regulatory Status:Regulatory IVD Catalog No.: 200ml K047Ready-to-Use Stable DAB/Plus with PermaRed/APAutoPlus Improving DermatologicDiagnosis DAB/Plus (K047). Formalin fixed paraffin embeddedhumantonsilstainedwithCytokeratin 5/14labeledwithStable estv ad tbe hn rdtoa wrig A sltos wih reduces which solutions, DAB hazardous working waste generation. traditional than stable and sensitive more is DAB/Plus Stable keeping. record permanent for mounted and cleared, mnehlabzl (E) Seies tie i DB a b dehydrated, be can DAB in stained Specimens (AEC). aminoethylcarbazole among pathologists because of its high sensitivity and cleaner background than DAB, a widely used chromogen for immunoperoxidase staining, is well accepted Pan MelanomaCocktail utilizing PermaRed/AP-AutoPlus MART1 melanomautilizing HMB45 melanomautilizing PermaRed/AP-AutoPlus PermaRed/AP-AutoPlus onmelanoma Pan Melanoma MART1 melanomautilizing HMB45 melanomautilizing utilizing StableDAB/Plus Stable DAB/Plus Stable DAB/Plus Cocktailonmelanoma 2/17/17 5:09PM Ancillary Reagents 2/17/17 5:09 PM www.dbiosys.com 3 6 0 3 6 0 ormalin- xed paraffin embedded tissue sections. ed, paraffin-embedded tissue. It consists It tissue. paraffin-embedded ed, ormalin- x Epitope Recovery, pH 8.0 (K 038). Epitope Recovery, 10X EDTA Buffer for Heat Induced for Buffer 10X EDTA ed paraffin embedded tissue sections. tissue embedded paraffin ormalin- xed ed paraffin embedded tissue sections. tissue embedded paraffin ormalin- xed ------10X EDTA Buffer For Heat Induced Epitope Recovery, pH Recovery, Epitope Induced Heat For Buffer 10X EDTA 8.0 K038 Concentrated 500ml K038 Concentrated No.: Catalog IVD Regulatory Status: Buffer Heat For Induced10X EDTA Epitope pH Recovery, 8.0 is designed for use during the heat induced epitope retrieval (HIER) step prior to immunohistochemistry on f bath, water microwave, by (often heat with combination in buffer this of use The or pressure cooker) has been shown modied Āduring to the formalin xation Āof tissue. This restore buffer is supplied as the a 10X antigenicity of proteins solution. stock HistoZyme Catalog No.: K046 Ready-to-Use 15ml Catalog No.: IVD Regulatory Status: over staining superior in results that enzymesolution proteolytic a is HistoZyme HistoZyme trypsin. and pepsin as such pretreatments, enzyme used traditionally requires K046-50 Ready-to-Use 50ml only a brief incubation recovery with HistoZyme, at will allow you to dilute the room primary antibody 5 to 10 temperature. staining. optimal Performing achieve and further antigen fold Montage Citrate Antigen Retrieval Solution Retrieval Antigen Citrate Montage K035-500AN 500ml No.: Catalog IVD Regulatory Status: Montage Citrate Antigen and RetrievalRetrieval Antigen Opus Montage the with together Solution, used when performance pH 6, is designed for Montage 360 Autostainer optimal System. This reagent is designed for use during the heat induced epitope retrieval (HIER) step prior to immunohistochemistry on f Montage EDTA Antigen Retrieval Solution Retrieval Antigen EDTA Montage K038-500AN 500ml No.: Catalog IVD Regulatory Status: Montage EDTA Antigen Retrieval Solution, pH 8 is designed for optimal performance when used together with the Montage Opus Antigen Retrieval and Retrieval Antigen Opus Montage the with together used when performance Montage 360 Autostainer System. This reagent is designed for use during the heat induced epitope retrieval (HIER) step prior to immunohistochemistry on f 129 ed paraffin embedded tissue sections. The sections. tissue embedded paraffin ormalin- xed ed paraffin embedded tissue sections. The sections. tissue embedded paraffin ormalin- xed ed paraffin embedded tissue sections. The sections. tissue embedded paraffin ormalin- xed ------Antigen Retrieval Solutions Retrieval Antigen The Antigen Retrieval technique is a novel method for the recovery of antigens from f from antigens of recovery the for method novel a is technique Retrieval Antigen The of heating tissue sections in the presence of an antigen retrieval solution. The quality of the staining result is largely dependent on strict on dependent largely is result staining the of quality The solution. retrieval antigen an of presence the in sections tissue heating of be may background the and light is staining the retrieved, incompletely are antigens the If protocol. retrieval antigen the to adherence high. Epitope retrieval techniques fall into two main categories, enzyme induced epitope recovery and heat induced epitope recovery. epitope induced heat and recovery epitope induced enzyme categories, main two into fall techniques retrieval Epitope high. Diagnostic BioSystems offers products for both enzyme and heat induced epitope retrieval. epitope induced heat and enzyme both for products offers BioSystems Diagnostic 10X Antigen Retrieval Buffer High, pH 10.0 Buffer Retrieval 10X Antigen K044 Concentrated 500ml K044 Concentrated No.: Catalog IVD Regulatory Status: 10X Antigen Retrieval Buffer High, pH 10.0 is designed for use during the heat induced epitope retrieval (HIER) step prior to immunohistochemistry on ed xed formalin paraffin embedded tissue sections. The use of this buffer in combination with heat (often by microwave, water bath, or pressure cooker) has cooker) pressure or bath, water microwave, by (often heat with combination formalin the modied Āduring proteins of antigenicity the restore to shown been solution. stock 10X a as supplied is buffer This tissue. xation Āof Antigen Unmasker System Unmasker Antigen DSI5030 Tablets 20 each Tablets DSI5030 No.: Catalog IVD Regulatory Status: Antigen Unmasker System is intended for heat-induced target retrieval prior to immunohistochemical staining procedures. It is free from heavy metals eliminating the risk of exposure to lab personnel, resolving handling and disposal and handling resolving personnel, lab to exposure of risk the eliminating problems. 10X Citrate Buffer For Heat Induced Epitope pHRecovery, 6.0 K035 Concentrated 500ml K035 Concentrated No.: Catalog IVD Regulatory Status: use for designed is 6.0 pH Recovery, Epitope Induced Heat For Buffer Citrate 10X during the heat induced epitope retrieval (HIER) step prior to immunohistochemistry on f on immunohistochemistry use of this buffer in combination with heat (often by water bath, microwave, or modied Ā proteins of antigenicity the restore to shown been has cooker) pressure during the formalin xation Āof tissue. This buffer solution. is supplied as a 10X stock 10X Citrate Buffer For Heat Induced Epitope pHRecovery, 7.0 K036 Concentrated 500ml K036 Concentrated No.: Catalog IVD Regulatory Status: use for designed is 7.0 pH Recovery, Epitope Induced Heat For Buffer Citrate 10X Ancillary Reagents Ancillary during the heat induced epitope retrieval (HIER) step prior to immunohistochemistry on f on immunohistochemistry use of this buffer in combination with heat (often by water bath, microwave, or modied Ā proteins of antigenicity the restore to shown been has cooker) pressure during the formalin xation Āof tissue. This buffer solution. is supplied as a 10X stock 10X Citrate Buffer For Heat Induced Epitope pHRecovery, 8.0 K037 Concentrated 500ml K037 Concentrated No.: Catalog IVD Regulatory Status: use for designed is 8.0 pH Recovery, Epitope Induced Heat For Buffer Citrate 10X during the heat induced epitope retrieval (HIER) step prior to immunohistochemistry on f on immunohistochemistry use of this buffer in combination with heat (often by water bath, microwave, or modied Ā proteins of antigenicity the restore to shown been has cooker) pressure during the formalin xation Āof tissue. This buffer solution. is supplied as a 10X stock Page 117-135 Hard Edit.pdf 13 Page 117-135 Hard Edit.pdf 14 Ancillary Reagents www.dbiosys.com immunohistochemistry immunohistochemistry (IHC) applications with the addition of a surfactant. B bffr ok wl fr aul n atmtd itptooy and histopathology automated and manual for well works buffer PBS Status:Regulatory IVD Catalog No.: DMRE404-01 Tablets 100each Phosphate Buffered Saline Tablets staining system. tblt.TeTS otis ufcat n alw fr egns o ped more pH spread uniformly to across tissue on section slides. can It also be used on other superior automated reagents for with allows and buffer surfactant TBS contains TBS quality The stability. high a equiring other procedures as laboratory well as applications immunohistochemistry automated and manual used when performance optimal together for with the Montage 360 System. Montage IHC Wash Buffer designed works well for is Buffer, Wash IHC Montage Status:Regulatory IVD Catalog No.: K005-500AN500ml 10X Montage IHC Wash Buffer on slides. It can also be used on an automated staining system. surfactant and allows for reagents to spread more uniformly across procedures tissue contains section TBS The stability. pH laboratory superior with buffer TBS other quality high a requiring as well as applications y immunohistochemistr solution. Buffers 10X Immuno Wash Buffer works well for manual and automated and manual for well works Buffer Wash Immuno 10X Status:Regulatory IVD Catalog No.: K005Concentrated 1Liter 10X Immuno Wash Buffer uig h frai xto o tsu. hs ue i sple a a 0 stock 10X a as supplied is buffer This tissue. xationĀof formalin the during pressure cooker) has been shown to restore the antigenicity of proteins modied Ā or bath, microwave,water by (often heat with combination in buffer this of use immunohistochemistry immunohistochemistry on f during the heat induced epitope retrieval (HIER) step prior to prior step (HIER) retrieval epitope induced heat the during 10X Tris-EDTA Buffer For Heat Induced Epitope Recovery, pH 9.0 is Status:designed Regulatory IVD for use Catalog No.: K043Concentrated 500ml pH .0 Recovery, Epitope Induced Heat For Tris-EDTABuffer 10X results in poor or no staining in IHC. Pepsin digestion of FFPE tissue sections sections tissue FFPE of improves digestion accessibility Pepsin of antibodies IHC. to in tissue antigens. staining no or poor in results masking This crosslinking. intrinsic their by nuclear) and membrane, (cellular, used commonly most (IHC), f (FFPE) of tissue sections prior digestion to application proteolytic of antibodies. for In immunohistochemistry used is Pepsin Status:Regulatory IVD Catalog No.: 50ml K009Ready-to-Use PepsinSolution procedures. xed, paraffin embedded tissue sections prior to performing in situ hybridization Proteinase K is specically Āformulated to achieve proteolytic digestion of formalin Status:Regulatory IVD Catalog No.: K030Concentrated 2ml 2 X Proteinase K Montage 360 System. the with together used when performance optimal for designed is Histo yme, Montage trypsin. and pepsin as such pretreatments, enzyme used traditionally solutionthatresults insuperiorstainingover enzyme Histo yme isaproteolytic Status:Regulatory IVD Catalog No.: K046-10AN10ml Montage HistoZyme ------ormalin- xed paraffin embedded tissue sections. The s uh s omln ms tsu antigens tissue mask formalin, as such xatives 3 60 ed paraffin-embedded paraffin-embedded ormalin- xed Visit usat: http://dbiosys.com/products/ancillaries 130 Accessory Reagents Secondary Secondary Systems in manual and automated IHC platforms. pcrm eaie oto hs en iee t wr wt Polymer-based with work to titered been has Control Negative Spectrum K053-2525ml is specically Ādesigned to work with rabbit, mouse and goat antibodies. the The K053-100100ml Broadstaining should be observed determine when the primary antibody is omitted. to This product used are controls Negative Status:Regulatory IVD Catalog No.: K053-066ml NegativeBroad Spectrum Control Western blotting techniques as well as immunohistochemistry. and forELISA used be solutions.can Background Blocker blocking serum-based to superior be to shown been has reagent antibody. blocking link This the with agent,eliminatingtheneedforBlocker isauniversal matchingspecies blocking osei bcgon drn imnsann tcnqe. Background techniques. immunostaining during reduce to nonspecic Ābackground used solution blocking serum-free unique a is Blocker Background Status:Regulatory IVD Catalog No.: 100ml K023Ready-to-Use Background Blocker mounted in aqueous based mounting medium such as C/C Mount (cat. be should and K002). ethanol dehydratedin be substrates/chromogenscannot above Red but can be used with BCIP/ NBT and BCIP/INT also. Specimens stained with the visualization of difficult to localize antigens. This enhancer works well with Fastwith well works enhancerantigens. Thislocalize to difficult of visualization nacr eoe h tetet ih usrt/hooe eals the enables substrate/chromogen with treatment with the sections before tissue enhancer of treatment single A fold. several phosphatase alkaline by generated signal the increase to solution stable new a introduced has DBS this enzyme requires the generation of an insoluble colored reaction end product. used asalabelfor insituhybridization andimmunohistochemistry. Detection of Alkaline Alkaline phosphatase, an enzyme derived from bovine intestinal mucosa, is often Status:Regulatory IVD Catalog No.: 250ml K011Ready-to-Use Alkaline Phosphatase Enhancer better penetration of tertiary antibodies. oim hoie n dtret t peet osei bnig n enable and nonspecicĀbinding prevent to detergents and chloride sodium tertiary the of in stability antibodies. Our Alkaline maximum proteins Phosphatase Diluent contains the optimal concentrations stabilizing of ensures with Diluent together Phosphatase pH Alkaline optimal The antibody. tertiary the the and environment presence the or absence of of of detergents pH can affect selection the strength, binding as Ionic as well as critical. the well stability is of as diluent appropriate dilution antibody correct to staining, order optimal an In obtain immunohistochemistry. for antibodies conjugated phosphatase laie hshts Dlet s pcclyĀeind o iue alkaline dilute to specicallyĀdesigned is Diluent Phosphatase Alkaline Status:Regulatory IVD Catalog No.: K028Concentrated 1000ml Background ReducingComponent) (With Alkaline Phosphatase Diluent ------o a atbd. No antibody. an of speci city 2/17/17 5:09PM CC/Mount™ Aqueous Permanent Mounting Medium Montage DAB Away Kit Catalog No.: K002 Ready-to-Use 30 ml Catalog No.: K072-500AN 500ml 3 6 0 K002-200 Ready-to-Use 200ml Regulatory Status: IVD Regulatory Status: IVD Montage DAB Away removes diaminobenzidine (DAB) stains and precipitate CC/Mount is an aqueous mounting medium with a high refractive index. When from surfaces. Contamination with DAB residue can be a problem that may affect applied to stained tissue sections, specimens can be permanently mounted staining quality or automated immunohistochemistry stainers. Bleach will only without chromogens fading. The advantages of CC/Mount include: no coverslip, reduce the color intensity of DAB stains, whereas, DAB Away removes the residual no exposure to organic fumes, permanent storage of slides and high resolution of DAB stain that may clog instrument probes and tubing. This kit can also be used to tissue specimens. CC/Mount is compatible with chromogens like AEC, DAB, Fast clean glassware used in the lab that has been exposed to DAB and has retained Red, BCIP/NBT, BCIP/INT and uorescent dyes like FITC and phycobiliproteins. The DAB stains even after normal cleaning. high pH ensures increased stability of uorescence. ------Montage Hematoxylin Elite PAP Pen Catalog No.: K056-100AN 100ml 3 6 0 Catalog No.: K039 Pen 1 each Regulatory Status: IVD Regulatory Status: IVD Hematoxylin is a histological staining reagent suitable for visualization of nuclei in Elite PAP pen is a special marking pen that provides a thin lm-like Āgreen-tinged tissue sections. Montage Hematoxylin, is designed for optimal performance hydrophobic barrier when a circle is drawn around a specimen on a slide. This when used together with the Montage 360 System. water repellent barrier keeps staining reagents localized on the tissue sections, prevents mixing of reagents when differentially staining two sections on the ------same slide, and allows use of less reagents per section. Insoluble in alcohol and acetone, PAP Pen markings can be optionally removed with xylene after the Montage Tween 20 staining procedure is complete. Catalog No.: K067-125 AN 125ml 3 6 0 Regulatory Status: IVD ------Tween 20 is a detergent (surfactant) commonly added to buffers and reagents for immunohistochemistry. Its purpose is to decrease background staining and Elite Mini PAP Pen enhance reagent spreading in automated and manual procedures. Catalog No.: K042 Pen 1 each Regulatory Status: IVD ------Elite Mini PAP pen is a special marking pen that provides a thin lm-like Āgreen- tinged hydrophobic barrier when a circle is drawn around a specimen on a slide. Mouse on Mouse Blocking Reagent This water repellent barrier keeps staining reagents localized on the tissue Catalog No.: K065 10ml sections, prevents mixing of reagents when differentially staining two sections Regulatory Status: IVD on the same slide, and allows use of less reagents per section. Insoluble in alcohol Mouse on Mouse (MOM) Blocking Reagent is a unique serum-free blocking and acetone, PAP Pen markings can be optionally removed with xylene after the solution used to reduce nonspecic Ābackground staining from mouse antibodies. staining procedure is complete. The Mini PAP pen is especially useful when This blocking reagent has been shown to be more superior than serum-based working with multiple sections on a single slide because its tip is ner Āthan the blocking solutions. regular PAP pen. ------10X Peroxidase Diluent I Fluoromount™ Catalog No.: K019 Concentrated 100ml Catalog No.: K024 Ready-to-Use 25ml Regulatory Status: IVD K024-200 Ready-to-Use 200ml Peroxidase is one of the most widely used enzyme markers in immunoassay Regulatory Status: IVD systems. Diluted peroxidase working reagent has a tendency to lose its activity Fluoromount is an innovative, aqueous-based mounting medium designed after a few weeks even at 4-8°C. Peroxidase Diluent I is specially designed to solve especially for the permanent preservation of uorescent specimens. this problem. This diluent will stabilize the peroxidase conjugate and will increase Fluoromount is to be used with tissue sections stained with a multitude of its shelf life to several years when stored at 4-8°C. Peroxidase Diluent I is free of uorescent dyes. This product is compatible with FITC, phycoerythrin, serum and proteins. Peroxidase Diluent I contains 0.1% Proclin 300 as a phycocyanin and allophycocyanin. It can also be used with other uorescent preservative. markers such as Texas Red and rhodamine. ------10X Peroxidase Diluent II Fluoromount/Plus™ Catalog No.: K020 Concentrated 100ml Catalog No.: K048 Ready-to-Use 25ml Regulatory Status: IVD K048-200 Ready-to-Use 200ml Peroxidase is one of the most widely used enzyme markers in immunoassay Regulatory Status: IVD systems. Diluted peroxidase working reagent has a tendency to lose its activity Fluoromount/Plus is an innovative, aqueous-based mounting medium designed after a few weeks even at 4-8°C. Peroxidase Diluent II is specially designed to solve especially for the permanent preservation of uorescent specimens. this problem. This diluent will stabilize the peroxidase conjugate and will increase Fluoromount/ Plus is to be used with tissue sections stained with a multitude of its shelf life for several years when stored at 4-8°C. Peroxidase Diluent II contains uorescent dyes. This product is compatible with FITC, phycoerythrin, an immunologically inert protein to further stabilize the protein-peroxidase phycocyanin and allophycocyanin. It can also be used with other uorescent conjugate. Peroxidase Diluent II contains 0.1% Proclin 300 as a preservative. markers such as Texas Red and rhodamine. ------
Immuno-Histosealer™ NEW Reagents Ancillary Catalog No.: K076 Regulatory Status: IVD RUO ImmunoHisto-Sealer™ is a preservation solution that acts as a sealant to improve tissue morphology and stain over an extended period of time. When applied to the stained section, specimens can be permanently mounted without chromogens fading. Additional benets Āof the ImmunoHisto-Sealer™ include: DBS offers a host of ancillaries saves hands on time when mounting slides, avoids the use of toxic chemicals such as xylene and eliminates accumulation of hazardous waste. to provide solutions to your IHC staining challenges.
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Page 117-135 Hard Edit.pdf 15 2/17/17 5:09 PM Peroxidase Block Catalog No.: K033 Ready-to-Use 50ml Regulatory Status: IVD Endogenous peroxidase activity has been observed in tissue sections during immunoperoxidase staining. If not properly suppressed, endogenous peroxidase can produce false signal as well as high background during the immunostaining. Treatment of tissue sections with Peroxidase Block prior to the application of primary antibody will suppress endogenous peroxidase activity. ------Primary Antibody Diluent (With Background Reducing Component) Catalog No.: K004 Ready-to-Use 250ml Regulatory Status: IVD In order to obtain optimal staining, correct dilution as well as selection of appropriate diluent is critical. Ionic strength, pH of the environment and the presence or absence of detergents can affect the binding as well as the stability of the primary antibody. The optimal pH together with stabilizing proteins in Primary Antibody Diluent ensures the maximum stability of primary antibodies. Our Primary Antibody Diluent contains optimal concentrations of sodium chloride and detergents to prevent nonspecic Ā binding and enable better penetration of primary antibodies. Primary Antibody Diluent is specically Ā Antigen Retrieval Solutions designed for diluting primary antibodies for immunohistochemistry. Both, monoclonal and polyclonal antibodies can be diluted in this buffer. ------10X Secondary Antibody Diluent (With Background Reducing Component) Catalog No.: K022 Concentrated 100ml Regulatory Status: IVD In order to obtain optimal staining, correct antibody dilution as well as selection of appropriate diluent is critical. Ionic strength, pH of the environment and the presence or absence of detergents can affect the binding as well as the stability of the secondary antibody. The optimal pH together with stabilizing proteins in Secondary Antibody Diluent ensures maximum stability of secondary antibodies. Our Secondary Antibody Diluent contains optimal concentrations of sodium chloride and detergents to prevent nonspecic Ā binding and enable better penetration of secondary antibodies. Secondary Antibody Diluent is specically Ā Mounting Media designed for diluting secondary antibodies for immunohistochemistry. ------TissueBond™ Reagent Catalog No.: K013 Ready-to-Use 7ml Regulatory Status: IVD Proper tissue adhesion to the glass slides is critical in the immunostaining process. Improper adhesion of tissue sections can lead to poor quality staining or even loss of tissue sections during the process of immunostaining. White glue, albumen, chromegelatin and poly-L-lysine have been used as tissue adhesives; however, they can increase the background during the staining process. Since epitope recovery may require harsh treatment with proteolytic enzymes, microwave treatment or treatment with saponin etc., there is a need for a tissue Pens adhesive which can irreversibly bind tissue sections to the glass without creating any background. Glass treated with TissueBond can be used for both paraffin as well as frozen tissue sections. ------Tissue Primer Catalog No.: K054 100ml Regulatory Status: IVD Tissue Primer is a universal enzyme blocking reagent to use in horse radish peroxidase (HRP) and alkaline phosphatase (AP) based immunohistochemical staining procedures done on paraffin tissue sections, frozen tissue sections and cell smears to suppress nonspecic Āstaining due to endogenous enzyme activity. Ancillary Reagents
Buffers
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Page 117-135 Hard Edit.pdf 16 2/17/17 5:09 PM Special Stains 2/17/17 5:09 PM www.dbiosys.com Copper Stain on copper deposits Copper Stain on copper in Liver (KT033). Human uterus stained with elastic stain (KT012). Human intestine stained with Colloidal Iron stain (KT007). Combined Eosinophil-Mast Cell (KT004). ------Colloidal Iron Colloidal KT007 No.: Catalog IVD Regulatory Status: This kit stains acid mucopolysaccharides in paraffin tissue sections. The acid mucopolysaccharides stain red. of shades stains collagen while blue, bright Copper KT033 No.: Catalog IVD Regulatory Status: This kit stains copper deposits in paraffin tissue Combined Eosinophil-Mast Cell Combined KT004 No.: Catalog IVD Regulatory Status: This kit stains eosinophils and mast cells sections. The copper deposits stain light blue. brown stain to nuclei the while red, simultaneously in paraffin tissue sections. Mast cells red. bright stain eosinophils while blue, bright stain Elastic KT012 No.: Catalog IVD Regulatory Status: sections. tissue paraffin bers Āin elastic stains kit This black and collagen stains red, The elastic bers Āstain yellow. stains tissue other the while
133 ial Stains ------Histology is the study and analysis of structure and function in biological tissues and cells. Specially formulated dyes and chemicals are are chemicals and dyes formulated Specially cells. and tissues biological in function and structure of analysis and study the is Histology used to give color to cellular tissue components for microscopic examination. Through this process diagnostic evaluations are made and made are evaluations diagnostic process this Through examination. microscopic for components tissue cellular to color give to used patient therapies are determined. are therapies patient time. setup minimizing box, the Diagnostic of BioSystems out offers right Special usage for Stains designed ranging are from They Acid-Fast Bacteria quality. staining Stain optimal Kit for packagedto Warthin-Starry Stain Kit. The reagents are Each Diagnostic BioSystems Special Stain Kit has been quality assured and comes with complete instructions for use. for instructions complete with comes and assured quality been has Kit Stain Special BioSystems Diagnostic Each Alcian Blue, pH 2.5 Blue, Alcian KT003 No.: Catalog IVD Regulatory Status: carboxylatedThis kit and stains acid mucins, sulfated strongly sulfated mucosubstances (except Acidic mucosubstances) in paraffin tissue sections. carboxylated and sulfated mucosubstances mucins, and the while the nuclei stain pink to red stain blue, stain pale pink. cytoplasm and background Alcian Blue, pH 1.0 Blue, Alcian KT002 No.: Catalog IVD Regulatory Status: This kit stains strongly sulfated Strongly mucosubstances. sulfated mucosub-stances stain blue in A.F.B. KT001 No.: Catalog IVD Regulatory Status: of bacilli tubercle and bacteria acid-fast stains kit This Mycobacterium genus in paraffin tissue Tubercle sections. bacilli and green. light other stains background the acid-fast and red bacteriabright stain paraffin tissue sections, while the nuclei stain pink to pink stain nuclei the while sections, tissue paraffin red and the cytoplasm and background stain pale pink. FORMAT SIZE: AND PACK Amyloid KT008 No.: Catalog IVD Regulatory Status: This kit stains amyloid deposits in sections. The amyloids stain paraffin pale pink tissue to red, while blue. stain nuclei the Each kit has sufficient reagents tests. for 100 Spec Page 117-135 Hard Edit.pdf 17 Page 117-135 Hard Edit.pdf 18 Special Stains www.dbiosys.com aii san ry o lc, hl te background the while stains green. black, to gray stain carinii paraffin tissuesections. The fungiandPneumocystis ise etos Te eioatr yoi ti blue while the background stain stains pale pylori blue. Helicobacter The sections. tissue This stains kit Helicobacter pylori in bacteria paraffin Status:Regulatory IVD Catalog No.: KT019 H.Pylori Rapid Stain Rapid H.Pylori in carinii Pneumocystis and fungi stains kit This Status:Regulatory IVD Catalog No.: KT015 G.M.S. background stains blue. etos Te er bclu san rd wie the while red, stains bacillus Lepra The sections. red respectively. and yellow stain nuclei the and tissues other while bacteria stain blue, Gram-negative bacteria stain red, bacteria in paraffin tissue sections. The Gram-positive pink. melanin stain nuclei the while black, brownto stain granules and cells argentaffin The sections. tissue This kit stains argentaffin cells and melanin in paraffin Status:Regulatory IVD Catalog No.: KT014 Fontana-Masson tissue paraffin in bacillus Lepra stains kit This Status:Regulatory IVD Catalog No.: KT013 Fite hs i san Ga-oiie n Gram-negative and Gram-positive stains kit This Status:Regulatory IVD Catalog No.: KT018 Gram cytoplasm stains light blue. the and violet to blue redgranules,stain with nuclei blue dark stain cells mast blue, stain pylori H. pink, paraffin in tissue sections. The microorganism erythrocytes stain gray, yellow or certain and cells mast This kit stains bone marrow cells, Helicobacter pylori, Status:Regulatory IVD Catalog No.: KT016 Giemsa ------with Giemsakit(KT016). Human bonemarrowstained Fontana MasonStain(KT014). Human Melanomastainedwith kit (KT013). Human lungstainedwithFite Pylori RapidStain(KT019). Pylori Human stomachstainedwithH. kit (KT015). Human lungstainedwithG.M.S. Gram stain(KT018). negative bacteriastainedwith Graom positiveandgram 134
cancer. vaginal cervical and uterine vaginal, in of detection for smears cells of variety a between differentiate h Ppnclo (A) ti Kt s eind to designed is Kit Stain (PAP) Papanicolaou The Status:Regulatory IVD Catalog No.: KT038 Papanicolaou Stain the nuclei stain blue. tissue paraffin in sections. The epithelial mucins mucin stains pink epithelial to red, stains while kit This Status:Regulatory IVD Catalog No.: KT024 Mucicarmine RNA stains and pink to green red. to blue-green stains DNA The sections. hs i san DA n RA n aan tissue paraffin in RNA and DNA stains kit This Status:Regulatory IVD Catalog No.: KT023 Methyl Green Pyronin to greenish blue, while the cells stain pink to violet. blue bers Āstainmyelin The sections. tissue paraffin in substance Nissl and sheath myelin stains kit This Status:Regulatory IVD Catalog No.: KT022 Luxol Fast Blue and other nuclei tissue stain the red and while pink respectively. blue, stain deposits iron The sections. tissue paraffin in iron ferric stains kit This Status:Regulatory IVD Catalog No.: KT021 Iron Stain the nuclei stain blue. sections. The fat cells and neutral fat stains red, while stainsfatcellsandneutralinfrozenThis kit tissue Status:Regulatory IVD Catalog No.: KT025 Oil RedO ------with Mucicarmine kit(KT024). Human colon tumorstained (KT022). Luxol Fast Bluestainonbrain with OilRedO(KT025). Frozen breasttissuestained with IronStain(KT021). inLiverStained Iron Deposits with PAP stain(KT038). Human Cervical smearstained (KT023). kit Methyl GreenPyronin Human tonsilstainedwith 2/17/17 5:09PM
Special Stains 2/17/17 5:09 PM www.dbiosys.com Human H. pylori infected stomach stained with Steiner kit (KT035). Massons Trichrome Stain on Massons Trichrome Tissue (KT034). Lung Human H. pylori infected stomach stained with Warthin Starry kit (KT036). Bone tissue stained with Von Bone tissue stained with Von Kossa stain (KT028). ------Trichrome Stain Trichrome KT034 No.: Catalog IVD Regulatory Status: This kit stains collagen and muscle in paraffin tissue red, Āstain bers intercellular and muscle The sections. Kossa Von KT028 No.: Catalog IVD Regulatory Status: This kit stains calcium deposits The calcium sections. deposits stain black, in while the paraffin tissue respectively. pink and red stain cytoplasm and nuclei while the nuclei and collagen stain black and blue respectively. Steiner KT035 No.: Catalog IVD Regulatory Status: This kit stains fungi, Helicobacter pylori, Legionella pneumophila and Spirochetes in paraffin tissue sections.tissueparaffinin Spirochetesand pneumophila TheLegionellapneumophila cat stainscratch fever, dark brown, Spirochetes, Helicobacter pylori and funvgi stain black,while the tanbackgroundstains oryellow, brown. cat scratch fever, Legionella pneumophila stain dark brown, Spirochetes, Helicobacter pylori and funvgi stain Warthin-Starry KT036 No.: Catalog IVD Regulatory Status: This kit stains Helicobacter pylori, Spirochetes, black, while the background stains yellow, tan or brown. ortan yellow, stainsbackground the whileblack, Legionella Legionella pneumophila and cat scratch fever bacteria in paraffin tissue sections. Helicobacter pylori, Legionella pneumophila stain stain bacteria fever dark scratch cat and Spirochetes while brown, black.
135 have been optimized for fast performance, Pneumocystis Stain Kit on (KT030). pneumocystis in Lung. Human uterus stained with Pirco Human uterus stained with Pirco Sirius Red (KT037). Human liver stained with reticulum stain (KT031). PTAH Stain on Uterus (KT029). Stain on Uterus PTAH Human interstine stained with stain (KT027). PAS Visit us at: http://dbiosys.com/products/special-stains us at: Visit ease of use, and provide the highest accuracy attainable. DBS Special Stain its ------Reticulum KT031 No.: Catalog IVD Regulatory Status: This kit stains reticulum bers Āin paraffin tissue Pneumocystis KT030 No.: Catalog IVD Regulatory Status: This kit stains Pneumocystis carinii in cytology Picro Sirius Red Stain Sirius Picro KT037 No.: Catalog The Picro-Sirius Red Stain Kit (For Collagen) is P.A.S. KT027 No.: Catalog IVD Regulatory Status: This kit stains fungi, glycogen and mucin in paraffin tissue sections. The basement membrane, fungi, sections. The reticulum rose. to bers Āpink stain stain background and gray nuclei the to while black, smears as well as paraffin tissue sections. The intended for use in the histological visualization of tissue in muscle to addition bers Āin III and I collagen sections. glycogen glycogen and mucin stain pink to nuclei and red, other while tissue the stain blue and green Pneumocystis carinii stains violet to purple and the green. to blue stains tissue connective respectively. P.T.A.H. KT029 No.: Catalog IVD Regulatory Status: This kit stains collagen, striated brin Āand muscle in brownish stains collagen The sections. tissue paraffin red to red, brin Āand muscle stain blue, while the nuclei stain dark blue. dark stain nuclei Page 117-135 Hard Edit.pdf 19 no e o se on o se ( ) H P A etection System, 1 1 i-1 Anti en, Index I—Product no e o se a it H P A etection System, 1 1 ANCILLARY REAGENTS F SF , FITC CONJUGATED ANTIBODIES A. SS A S , 1 omp ement FI - on ate Anti o y, 11 1 Pero i ase i ent I, 1 1 1 P A -1, 1 c omp ement FI - on ate Anti o y, 11 1 Pero i ase i ent II, 1 1 c omp ement FI - on ate Anti o y, 11 1, n othe ia e , 1 1 Secon ary Anti o y i ent, 1 Fi rino en FI - on ate Anti o y, 11 1(P A -1), 1 A a ine Phosphatase i ent, 1 I A (a pha chain) FI - on ate Anti o y, 11 1, 1 A a ine Phosphatase nhancer, 1 I ( amma chain) FI - on ate Anti o y, 11 ac ro n oc er, 1 , I ( chain) FI - on ate Anti o y, 11 roa Spectr m e ati e ontro , 1 , n othe ia e , appa i ht hain FI - on ate Anti o y, 11 o nt A eo s Permanent o ntin e i m, 1 1 1, Fo ic ar en ritic e ar er, am a i ht hain FI - on ate Anti o y, 11 ite ini PAP Pen, 1 1 , e F, P, PRIMARY ANTIBODIES ite PAP Pen, 1 1 α-Actinin, Sarcomeric, H A , F oromo nt P s, 1 1 α-1-Antichymotrypsin, , F oromo nt, 1 1 α-1-Antitrypsin, , onta e Hemato y in, 1 1 α-1-Antitrypsin(S PI A1), onta e een , 1 1 α-1-Fetoprotein (AFP), e ocyte ommon Anti en ( A), o se on o se oc in ea ent, 1 1 α Fetoprotein (AFP), A, e , Pero i ase oc , 1 α Fetoprotein (AFP), , e , Primary Anti o y i ent, 1 α Fetoprotein (AFP), e ra e A hesion o ec e-1 ( A -1), iss e on ea ent, 1 Actin, α-Smooth sc e, , iss e Primer, 1 A H ( - ermina ), 1 P ate et ycoprotein IIIa, ANTIGEN RETRIEVAL SOLUTIONS Actin, sc e, 1 Anti en etrie a er Hi h, pH 1 , 1 Actin, Pan sc e, , 1 itrate er For Heat In ce pitope eco ery, pH , 1 Actin, Sarcomeric, , 1 itrate er For Heat In ce pitope eco ery, pH , 1 A eno ir s, , acropha e, 1 itrate er For Heat In ce pitope eco ery, pH , 1 A renocorticotropic Hormone (A H), , acropha e, A renocorticotropic Hormone (A H), 1 A er For Heat In ce pitope eco ery, pH , 1 , ymphoi ar er, 1 ris- A er For Heat In ce pitope eco ery, pH , 1 Ar inase 1, 1 a, Proteinase , 1 Ar inase 1, 1 Anti en nmas er System, 1 A min, 1 a Anti en, Histo yme, 1 Amy oi A omponent, 1 a, e , onta e itrate Anti en etrie a So tion, 1 Amy oi Prec rsor Protein (APP), 11 a m -1, e ar er, onta e A Anti en etrie a So tion, 1 β-Amy oi Protein, 11 Fas, Anap astic ymphoma inase (A ) p , 11 onta e Histo yme, 1 I , in s Sarcoma ar er , So tion Pepsin, 1 An ro en eceptor, 11 , BUFFERS c - ncoprotein, 1 1 Imm no ash er, 1 c - ncoprotein, 1 , 1 onta e IH ash er, 1 c - ncoprotein, 1 I , Phosphate ere Sa ine a ets, 1 c - , 1 1 , CHROMOGENS c - , 1 11 , ANTIBODIES FOR DERMAPATH c - ncoprotein, 1 11 c- it, H , 1 c -1 , 1 1 , A -1 e an-A, 1 c - , Apoptosis ar er, 1 e anoma oc tai , 1 c - , Apoptosis ar er, 1 1 , i F, 1 1 F 1, 1 c A, S1 , 1 A1, 1 c , CHROMOGENS FOR AP, , 1 , IP I hromo en S strate it, 1 A 1 - , 1 , A 1 - , 1 IP hromo en S strate it, 1 , 1 Fast e Sa t a et it, 1 A 1 - Sia y e is A ( I mor ar er), 1 -er - ncoprotein, 1 Fast e Sa t a ets, 1 A 1 - Sia y e is A, 1 Perma e AP, 1 A 1 , 1 -er - ncoprotein, 1 Perma e AP-A to, 1 A 1 , 1 A A , 1 Perma e P s AP, 1 a herin, Pan, 1 horionic ona otropin (h ), Perma reen AP, 1 a herin, Pan, 1 hromo ranin A, Perma reen P s AP, 1 a in in- - , 1 hromo ranin A, Perma e AP, 1 a citonin, 1 hromo ranin A, Perma e AP-A to, 1 a citonin, 1 Perma e AP-A toP s, 1 a esmon, 1 hromo ranin A, CHROMOGENS FOR HRP a esmon, H (h- a esmon), 1 hromo ranin A, A nhancer, 1 a ponin, 1 hromo ranin A, A H P hromo en S strate it, 1 a ponin-1, 1 a in 1, A H P hromo en S strate it, 1 a retinin, 1 a in , Hi h ontrast A , 1 a retinin, 1 a in , Intensi Fire, 1 A , 1 -myc F, ono A P s, 1 arcinoem ryonic Anti en ( A), 1 Perma ac H P, 1 arcinoem ryonic Anti en ( A), 1 o a en ype I , Perma e H P, 1 aspase 1 Inter e in-1-β on ertin n yme, yc in 1, Perma e H P, 1 aspase , yc in 1, Perma e o H P, 1 aspase PP , yc in 1, Sta e A P s, 1 aspase F I , yc in 1, DETECTION SYSTEMS atenin, β, 1 yc in 1 c -1, POLYVUE—TWO STEP DETECTION SYSTEM atenin, β, 1 yc in 1, onta e Po y e P s A to etection System, 1 athepsin , 1 Po y e P s o se a it H P A etection System, 1 1a, 1 yc in Protein, Po y e o se a it H P A etection System, 1 1a, yc in Protein, STREPTAVIDIN BIOTIN BASED DETECTION SYSTEM 1a H A1, yc oo y enase- ( - ), A Phos o se it (Fast e ), 1 , yc oo y enase- ( - ), A Phos o se a it it (Fast e ), 1 , e , ystatin A, A Phos o se a it Stainin it, 1 , e , ystic Fi rosis ransmem rane e ator ( F ), A Phos o se Stainin it, 1 , e , yto eratin, A Phos a it it (Fast e ), 1 , ar y e ar er, A Phos a it Stainin it, 1 , yto eratin, Aci ic ( ype I or ), Pero i ase o se it, 1 e, yto eratin A 1, Aci ic, Pero i ase o se it (A ), 1 , yto eratin A 1 A , Pero i ase o se it ( A i i ), 1 , yto eratin A , asic, Pero i ase o se it ( A a ets), 1 , yto eratin, Pero i ase o se a it it, 1 , yto eratin , Pero i ase o se a it it (A ), 1 , yto eratin oc tai , Pero i ase o se a it it ( A i i ), 1 , yto eratin 1 , Pero i ase o se a it it ( A a ets), 1 , e , yto eratin , Pero i ase a it it, 1 1 , yto eratin , Pero i ase a it it (A ), 1 1 A A, Pero i ase a it it ( A i i ), 1 yto eratin , Pero i ase a it it ( A a ets), 1 11c, yto eratin , 1 ea y-to- se its omponents, 1 1 , yto eratin , 1 A P a e , 1 1 ran ocyte Associate Anti en, yto eratin , o o ec ar ei ht, 1 H P a e , 1 1 ran ocyte Associate Anti en, yto eratin 1 , 1 o se in , 1 1 ran ocyte Associate Anti en, yto eratin 1 , yto eratin 1 , o se a it in , 1 S A1, a it in , 1 yto eratin 1 1 , , UNOVUE ONE STEP DETECTION REAGENTS yto eratin 1 , no e o se AP etection ea ent, 1 , e , yto eratin 1 , no e o se H P etection ea ent, 1 1, yto eratin 1 , no e o se a it AP etection ea ent, 1 1, e , yto eratin 1 , no e o se a it H P etection ea ent, 1 , yto eratin 1 , yto eratin 1 , no e a it AP etection ea ent, 1 , UNOVUE PLUS ONE STEP DETECTION SYSTEM yto eratin 1 , , onta e no e P s A to etection System, 1 1 yto eratin 1 , a it no e AP Perma e etection System, 1 1 I - α, yto eratin , no e o se H P A etection System, 1 1 , yto eratin ,
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Page 136-140 Edit Index Edited.pdf 1 2/17/17 5:09 PM . yto eratin , i- , 1 A - A - , 1 yto eratin, Hi h o ec ar ei ht, i ney-Speci c a herin ( SP- a herin) H1 , 1 A - A - , 1 yto eratin, Hi h o ec ar ei ht, SP- a herin, 1 artrate- esistant Aci Phosphatase ( AcP), 1 yto eratin, Pan, (p ), enascin , 1 yto eratin, i e, ermina eo yn c eoti y rans erase ( t), 1 ytome a o ir s ( oc tai ), am a i ht hain, ermina eo yn c eoti y rans erase ( t), 1 esmin, am a i ht hain, hrom ospon in ( SP), 1 esmin, am a i ht hain, hymi ine Phosphory ase P ate et- eri e n othe ia e ro th Factor, 1 esmo ein-1, am a i ht hain, hyro o in, 1 A Po ymerase, β, aminin, hyro o in, 11 1, e ocyte ommon Anti en ( A) , hyro o in, 11 ystrophin, e is , hyroi Pero i ase, 11 F-1 ranscription Factor, yso yme rami ase, hyroi ranscription Factor-1 ( F-1), hyroi an n pithe ia ar er, 11 F- ranscription, acropha e, I P- , 111 - a herin, a or a t Protein ( P) P, I P- , 111 - a herin, amma o in-A, F a pha ( mor ecrosis Factor a pha), 111 - a herin , A -1, opoisomerase II a pha, 11 astin, A -1 e an-A A A, opoisomerase II, 11 p- A , A -1 e an-A, e anoma ar er, rans errin, 11 p- A , ast e hymase, rans ormin ro th Factor , 11 p- A , ast e ryptase, rans taminase II, 11 pi erma ro th Factor eceptor ( F ), e anoma, in-α, 11 e anoma, pi erma ro th Factor eceptor ( F ), 1 yrosinase, e anoma ar er, 11 e anoma oc tai , pi erma ro th Factor eceptor ( F ), 1 asc ar n othe ia ro th Factor ( F), 11 esothe ioma, pi erma ro th Factor eceptor ( F ), 1 asc ar n othe ia ro th Factor ( F), 11 pithe ia Anti en, 1 ( )- ethy anine- A- ethy trans erase ( ), asc ar n othe ia ro th Factor ( F), 11 pithe ia Anti en, icrophtha mia ranscription Factor ( i F), i in, 11 H-1, pithe ia em rane Anti en ( A), imentin, 11 pithe ia em rane Anti en ( A), P- , imentin, Porcine, 11 pstein- arr ir s ( ), SH ( ismatch epair Protein), i m s mor 1 ( t1), 11 1, SH , i m s mor 1 Protein ( t1), 11 , cin A astric cin, i m s mor1 Protein ( t1), 11 stro en eceptor, cin astric cin ( ), 1 ( i ms mor 1), 11 stro en eceptor, 1 Protein, 1, 11 ye in asic Protein ( P), stro en eceptor, AP , 11 stro en eceptor A pha, ye oi ar er ( m ), SPECIAL STAINS rin p 1 yto i in, ye opero i ase, Factor III e ate Anti en on i e ran Factor, ye opero i ase, A F , 1 Factor III e ate Anti en on i e ran Factor, yo 1, A cian e, pH 1 , 1 Factor III-A, yo enin, A cian e, pH , 1 Factor III-A, yosin, S e eta (Fast), 1 Amy oi , 1 apsin A, 1 Fascin-1, o oi a Iron, 1 Ferritin i ht hain, e ro aments, 1 e ron Speci c no ase ( S ), 1 om ine osinophi - ast e , 1 FSH- eceptor, e ron Speci c no ase, o ine ( S ), opper, 1 Fi ro ast, , astic, 1 Fi ronectin, , Fite, 1 F -1 F , S amma, Fontana- asson, 1 F t-1 F 1, - , iemsa, 1 F t- , - , S , 1 a ectin- , p 1 AF1 ip1 S i1 Pic1 itotic Inhi itor, ram, 1 astrin F, P, p ip1, H Py ori api Stain, 1 ia Fi ri ary Aci ic Protein ( FAP), p , Iron Stain, 1 ia Fi ri ary Aci ic Protein ( FAP), p , o Fast e, 1 ia Fi ri ary Aci ic Protein ( FAP), p , ethy reen Pyronin, 1 tamate ecar o y ate ( A ), p , cicarmine, 1 -1, p , ycophorin A, p ip , i e , 1 ycophorin A a, p ip , Papanico ao Stain, 1 p Anap astic ymphoma inase, ycophorin , P A S , 1 p1 atenin, ran ocyte, Picro Siri s e Stain, 1 p S α- ethy acy - oA acemase (A A ), Pne mocystis, 1 ypican- ( P ), p s, P A H , 1 ypican- ( P ), Pancreatic Po ypepti e, ran yme , 1 PA - , etic m, 1 ross ystic isease F i Protein-1 ( FP-1 ), 1 PA , Steiner, 1 ro th Hormone, 1 PA , richrome Stain, 1 Hairy e e emia, 1 PA - , on ossa, 1 H - eta, PA - , arthin-Starry, 1 Heat Shoc Protein (HSP ), P 1, Heat Shoc Protein (HSP ), Per orin, He ico acter py ori, PI ( a it anti-p , o se anti- yto eratin H ) a it anti-p S, Hepatitis ore Anti en (H cA ), P ate et- eri e ro th Factor (P F), Hepatitis S r ace Anti en (H sA ), P S , Hepatocyte Speci c Anti en, Pne mocystis carinii, HepPar-1, Po y A P- i ose Po ymerase, (PA P), Her r , Pro esterone eceptor, 1 H ne , Pro esterone eceptor, 1 Here in F F e re in, Pro esterone eceptor, 1 Herpes Simp e ir s ype I (HS 1), Pro esterone eceptor, 1 Herpes Simp e ir s ype I (HS 1), Prohi itin, 1 1 Herpes Simp e ir s ype I II (HS 1 ), Pro i eratin e c ear Anti en (P A), 1 1 Herpes Simp e ir s ype II (HS ), Prostate Speci c Anti en (PSA), 1 1 Herpes Simp e ir s ype I II (HS 1 HS ), Prostate Speci c Anti en (PSA), 1 1 Herpes Simp e ir s ype II (HS ), Prostate Speci c Anti en (PSA), 1 Herpes ir s (HH ), Prostate Speci c Anti en (PSA), 1 H A- (β chain o P, ), Prostate Speci c em rane Anti en (PS A), 1 HP -1 , Prostate Speci c em rane Anti en (PS A), 1 H man Papi oma ir s ype 1 (HP 1 ), Prostatic Aci Phosphatase (PSAP), 1 Hypo ia-In ci e Factor-α (HIF-1α), Prostatic Aci Phosphatase (PSAP), 1 I A, Protein ene Pro ct (P P ), 1 I , a 1, 1 I , ena e arcinoma ( p ), 1 I , etino astoma ene Protein ( ), 1 I , et ncoprotein, 1 PA p , 1 I , S-1 , 1 I , S-1 , 1 Inhi in α, S-1 , 1 Ins in, S-1 , eta, 1 Ins in, Smooth sc e yosin (S S-1), 1 appa i ht hain, Somatostatin eceptor, 1 appa i ht hain, S 1 , 1 appa i ht hain, S 1 , 1 S r i in, 1 A , Synaptophysin, 1 i- , 1 Synaptophysin, 1
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Page 136-140 Edit Index Edited.pdf 2 2/17/17 5:09 PM Index II - Clone Listing C3D-1, 27 DBR16.6, 13 KS-1A3, 52 CLONE C4D204, 14 DBR16.8, 18 KS 20.8, 55 1A4, 8 CALP (same as hCP), 18 DBR16.9, 115 L26, 28 1A4 + 5C5, 8 CAM 5.2, 19 DC10, 14 LHK15, 53 1B10, 66 CAMVIR-1, 77 DC17 + DC34, 40 LHP1, 52 1B12, 29 CB-955, 77 DCS-6, 45 LK2H10, 42 1D4, 109 CC1, 85 DCS-60.2, 93 LL002, 53 1F6, 23 CC49, 108 DCS-72.F6, 93 LL025, 53 1F8, 38, 104 CD20/MS4A1, 27 DCS-120, 40 LN2, 36 1FC, 24 CH-19, 16 DDG9 + CCH2, 56 LN22, 13 2B6, 41 COL-1, 8, 19 DE-K10, 52 LN53, 76 2B11 & PD7/26, 83 COL-94, 44 DE-K13, 52 LP34, 50 2F11, 91 CR3/43, 76 DE-SQ, 55 M3A7, 47 2H12, 15 CS1, CS2, CS3, CS4, 62 DF-T1, 32 M58 + M73, 09 3A4, 111 CUB 7402, 112 DM1A, 113 MAC387, 84 3C12, 64 CY-90, 54 DO-7, 95 mcl, 10 3CSP03, 20 D5, 87 DOG1.1, 57 MMA (same as LeuM1), 27 3E6, 102 D5/16 B4, 49 E2E3, 79 MNF116, 48 3E7, 73 D33, 56 E3, 53 MoAb47, 110 3F6, 99 DAK-Tg6, 110 E11, 32 MT3.1, 87 4C4.9, 105 DB10.1, 31 E29, 62 MUM1p, 89 4C7, 34, 83 DBA.44, 71 EA-53, 6 MY-1, 27 4E2F04, 58 DBMM1, 15 EP1, 64 MY32, 91 4KB5, 34 DBM15.1, 38 EP2, 100 N10/2, 82 5.2F, 90 DBM15.10, 106 EP3, 74 NK-1, 34 5A4, 95 DBM15.11, 116 EP6, 59 NKI/C3 (same as MX-49.129.5), 35 5B10, 98 DBM15.12, 10 EP8, 38 NRG1.1, 93 5C5, 9 DBM15.13, 10 EP9, 94 O10, 21 5D3, 51 DBM15.14, 81 EP10, 39 OCH1E5, 73 5D3 + LP34, 56 DBM15.15, 92 EP16, 51 OV185:1, 16 6F2, 68 DBM15.16, 26 EP22, 61 OV-TL 12/30, 51 6F11, 63 DBM15.17, 69 EP23, 54 OZ12, 77 6F-H2, 115 DBM15.18, 115 EP24/EP67, 49 PASE/4LJ, 103 7D5, 74 DBM15.19, 7 EP25, 41 PC10, 101 8F1, 63 DBM15.2, 108 EP32, 105 PD7/26 + 2B11, 33, 83 8G7G3/1, 110 DBM15.21, 89 EP36, 12 P-GF.44C, 109 9C4, 67 DBM15.22, 43 EP38, 43 PG-M1, 36 9E10, 44 DBM15.23, 103 EP41, 23 PN-15, 104 10D6, 39 DBM15.24, 97 EP43, 85 PNL2, 86 12.3.4 + 1.1.1, 75 DBM15.25, 92 EP48, 16 QBEND/10, 32 13A3, 46 DBM15.26, 30 EP64, 28 R1, 79 13H4, 96 DBM15.27, 12 EP66, 96 R1/69, 78 20.7.1, 74 DBM15.28, 111 EP68, 33 RET01 (same as 3F8), 104 25D12, 88 DBM15.29, 97 EP78, 31 Ret40f, 70 31G7, 61 DBM15.30, 6 EP80, 22 SEN28, 108 33-2-5, 116 DBM15.31, 60 EP88, 32 SH-B1, 105 34βE12, 55, 98 DBM15.33, 33 EP109, 101 SMMS-1, 106 35H9, 101 DBM15.34, 102 EP111, 63 SP1, 64 35βH11, 51 DBM15.35, 7 EP122, 115 SP2, 100 44, 88 DBM15.36, 15 EP138, 78 SP3, 41 45M1, 88 DBM15.37, 112 EP143, 93 SP4, 46 47DC141, 40 DBM15.38, 8 EP154, 30 SP5, 94 51RAD01, 103 DBM15.4, 41 EP171, 80 SP6, 81 56C6, 26 DBM15.41, 71 EP172, 82 SP7, 22 57P06, 95 DBM15.42, 66 EP195, 26 SP8, 11 59A5, 90 DBM15.43, 83 EP201, 39 SP9, 61 61, 57 DBM15.44, 114 EP204, 24 SP11, 107 100/D5, 12 DBM15.46, 60 EP218, 29 SP12, 43 111.6, 60 DBM15.47, 76 EP266, 109 SP13, 19 123C3.D5, 34 DBM15.48, 98 EP268, 106 SP16, 25 124, 12 DBM15.49, 59 EP274, 38 SP17, 17 144B, 25 DBM15.55, 98 EPR 9092, 84 SP18, 36 151, 13 DBM15.50, 73 EV9, 102 SP19, 25 156-3C11, 33 DBM15.51, 34 F5D, 90 SP20, 114 1032, 84 DBM15.52, 71 F7.2.38, 22 SP21, 47 1808, 58 DBM15.53, 57 F8/86, 64 SP23, 29 A6.1, 109 DBM15.54, 80 G168-15, 87 SP28, 114 A16-4, 99 DBM15.55, 21 GA5, 68 SPM471, 58 A53-B/A2.26, 54 DBM15.56, 108 GLK-2, 14 SYP02, 107 A103, 85 DBM15.57, 72 GP1.4, 62 T311, 113 AA1, 66 DBM15.58, 50 H-6, 82 UCHL1, 34 AE1, 48 DBM15.59, 67 HBME-1, 87 V9, 114 AE1 + AE3, 48 DBM15.6, 65 HE12, 46 V152, 45 AE3, 49, 54 DBM16.7, 85 hHCD, 17 VG1, 113 AR 441, 11 DBM15.9, 35 HHF35, 8 VI-H14, 91 B72.3, 107 DBR16.3, 92 HM47/A9, 36 VU-1D9, 82 BA-4, 59 DBR16.11, 50 HM57, 37 W27, 72 BAM-10, 11 DBR16.12, 30 HMB45, 86 WR-23/2/3/3, 47 BC12, 97 DBR16.13, 22 HMB45 + A103 + T311, 86 Wue-AC5, 14 Ber-EP4, 61 DBR16.14, 15 HO36-1.1, 37 XM26, 49 Ber-H2, 30 DBR16.15, 59 HP6054, 82 XM26 + LL002, 50 BM-2, 70, 89 DBR16.16, 26 II-14-10, 101 Y2/51, 35 Bp53-12, 94 DBR16.17, 70 IL2R.1, 29 BV2, 45 DBR16.18, 81 JC/70A, 31 BV5, 74 DBR16.19, 38 JC159, 69 BV6, 97 DBR16.2, 18 K36aC10, 79 BV7, 100 DBR15.20, 70 KCG1.1, 91 BV11, 28 DBR16.20, 42 KH95, 58 BV12, 55 DBR16.3, 92 Ki-S1, 111 C241:5:1:4, 15 DBR16.4, 31 KP1, 35 C3, 7 DBR16.5, 48 KP-53, 80
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Page 136-140 Edit Index Edited.pdf 3 2/17/17 5:09 PM Index III—RUO for U.S. Market Cystic Fibrosis Transmembrane Estrogen Receptor Alpha (EP1) Adenovirus Regulator (CFTR) Regulatory Status: RUO Catalog No.: RMAB051R Concentrated 0.5ml Regulatory Status: RUO Regulatory Status: RUO RMPD051R Prediluted 6ml Catalog No.: Mob355R Concentrated 1ml Catalog No.: Mob378R Concentrated 1ml Mob355-05R Concentrated 0.5ml Mob378-05R Concentrated 0.5ml GLUT-1 Regulatory Status: RUO ALK p80 (5A4) DNA Polymerase, β Catalog No.: RP128R Concentrated 1ml RP128-05R Concentrated 0.5ml Regulatory Status: RUO Regulatory Status: RUO Catalog No.: MOB416R Concentrated 1ml Catalog No.: Mob319R Concentrated 1ml MOB416-05R Concentrated 0.5ml Mob319-05R Concentrated 0.5ml Glutamate Decarboxylate 65 (GAD65) BOB.1/OBF.1 E2F-1 Transcription Factor Regulatory Status: RUO Regulatory Status: RUO Regulatory Status: RUO Catalog No.: RP075R Concentrated 1ml Catalog No.: Mob445R Concentrated 1ml Catalog No.: Mob381R Concentrated 1ml RP075-05R Concentrated 0.5ml Mob445-05R Concentrated 0.5ml Mob381-05R Concentrated 0.5ml HER2/Erb2 (EP3) BRCA1 E2F-4 Transcription Factor Regulatory Status: RUO Regulatory Status: RUO Regulatory Status: RUO Catalog No.: RMAB049R Concentrated 0.5ml Catalog No.: Mob424R Concentrated 1ml Catalog No.: Mob382R Concentrated 1ml RMPD049R Prediluted 6ml Mob424-05R Concentrated 0.5ml Mob382-05R Concentrated 0.5ml HER2/neu Caspase 3 (3CSP03) Epidermal Growth Factor Receptor Regulatory Status: RUO Regulatory Status: RUO (EGFR) (111.6) Catalog No.: RMAB026R Concentrated 0.5ml Catalog No.: Mob309R Concentrated 1ml Regulatory Status: RUO RMPD026R Prediluted 6ml Mob309-05R Concentrated 0.5ml Catalog No.: Mob267R Concentrated 1ml Mob267-05R Concentrated 0.5ml Herpes Simplex Virus Type I (HSV1) Caspase 3/CPP32 PDM132R Prediluted 6ml Regulatory Status: RUO Regulatory Status: RUO Catalog No.: RP018R Concentrated 1ml Catalog No.: RP096R Concentrated 1ml Epidermal Growth Factor Receptor RP018-05R Concentrated 0.5ml RP096-05R Concentrated .05ml (EGFR) (31G7) PDR032R Prediluted 6ml Regulatory Status: RUO Caspase 8/FLICE Catalog No.: Mob461R Concentrated 1ml Herpes Simplex Virus Type I (HSV1) Regulatory Status: RUO Mob461-05R Concentrated 0.5ml (20.7.1) Catalog No.: RP097R Concentrated 1ml Regulatory Status: RUO RP097-05R Concentrated 0.5ml Epidermal Growth Factor Receptor Catalog No.: PDM080R Prediluted 6ml CD117 (EP10) (EGFR) (SP9) Regulatory Status: RUO Herpes Simplex Virus Type I & II Regulatory Status: RUO Catalog No.: RMAB020R Concentrated 0.5ml (HSV1 & 2) Catalog No.: RMAB039R Concentrated 0.5ml RMPD020R Prediluted 6ml Regulatory Status: RUO RMPD039R Prediluted 6ml Catalog No.: RP162R Concentrate 1 ml RP162-05R Concentrate 0.5 ml CD117/c-Kit Epidermal Growth Factor Receptor(EGFR) (EP22) Regulatory Status: RUO Herpes Simplex Virus Type I & II Catalog No.: RP063R Concentrated 1ml Regulatory Status: RUO RP063-05R Concentrated 0.5ml Catalog No.: RMAB064R Concentrated 0.5ml (HSV1 & HSV2) PDR045R Prediluted 6ml RMPD064R Prediluted 6ml Regulatory Status: RUO Catalog No.: PDR034R Prediluted 6ml c-erbB-2 Oncoprotein Epstein-Barr Virus (EBV) PDR034-10RPR Prediluted 10ml Regulatory Status: RUO Regulatory Status: RUO Catalog No.: RP006R Concentrated 1ml Catalog No.: Mob194R Concentrated 1ml Herpes Simplex Virus Type II (HSV2) RP006-05R Concentrated 0.5ml Mob194-05R Concentrated 0.5ml Regulatory Status: RUO PDR003R Prediluted 6ml PDM128R Prediluted 6ml Catalog No.: RP019R Concentrated 1ml RP019-05R Concentrated 0.5ml c-erbB-2 Oncoprotein (SP3) Estrogen Receptor PDR033R Prediluted 6ml Regulatory Status: RUO Regulatory Status: RUO Catalog No.: RMAB008R Concentrated 0.5ml Catalog No.: RP141R Concentrated 1ml Herpes Simplex Virus Type II (HSV2) RMPD008R Prediluted 6ml RP141-05R Concentrated 0.5ml (12.3.4+1.1.1) Regulatory Status: RUO Claudin 1 Estrogen Receptor (1D5) Catalog No.: PDM081R Prediluted 6ml Regulatory Status: RUO Regulatory Status: RUO Catalog No.: RP153R Concentrated 1ml Catalog No.: Mob195R Concentrated 1ml Herpes Virus 8 (HHV8) RP153-05R Concentrated 0.5ml Mob124R Concentrated 0.5ml Regulatory Status: RUO PDM001-01R Prediluted 6ml Catalog No.: Mob395R Concentrated 1ml Claudin 4 Mob395-05R Concentrated 0.5ml Regulatory Status: RUO Estrogen Receptor (6F11) Catalog No.: RP156R Concentrated 1ml Regulatory Status: RUO Human Papilloma Virus Type 16, RP156-05R Concentrated 0.5ml Catalog No.: Mob121R Concentrated 0.5ml PDM048R Prediluted 5ml HPV 16 Regulatory Status: RUO Claudin 5 Catalog No.: Mob394R Concentrated 1ml Regulatory Status: RUO Estrogen Receptor (SP1) Mob394-05R Concentrated 0.5ml Catalog No.: RP157R Concentrated 1ml Regulatory Status: RUO PDM166R Prediluted 6ml RP157-05R Concentrated 0.5ml Catalog No.: RMAB001R Concentrated 0.5ml RMPD001R Prediluted 6ml
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Page 136-140 Edit Index Edited.pdf 4 2/17/17 5:09 PM Hypoxia-Inducible Factor-α (HIF-1α) Pneumocystis Carinii Rad51 Regulatory Status: RUO Regulatory Status: RUO Regulatory Status: RUO Catalog No.: Mob311R Concentrated 1ml Catalog No.: Mob091R Concentrated 1ml Catalog No.: Mob324R Concentrated 1ml Mob311-05R Concentrated 0.5ml Mob091-05R Concentrated 0.5ml Mob324-05R Concentrated 0.5ml
Insulin-Like Growth Factor-1 Poly ADP-Ribose Polymerase, (PARP) TIMP-2 Receptor alpha Subunit, IGF-1R Regulatory Status: RUO Regulatory Status: RUO Catalog No.: RP067R Concentrated 1ml Catalog No.: Mob318R Concentrated 1ml Regulatory Status: RUO RP067-05R Concentrated 0.5ml Mob318-05R Concentrated 0.5ml Catalog No.: Mob375R Concentrated 1ml Mob375-05R Concentrated 0.5ml Progesterone Receptor TIMP-3 Regulatory Status: RUO Regulatory Status: RUO MMP-9 Catalog No.: RP146R Concentrated 1ml Catalog No.: RP072R Concentrated 1ml Regulatory Status: RUO RP146-05R Concentrated 0.5ml RP072-05R Concentrated 0.5ml Catalog No.: RP066R Concentrated 1ml RP066-05R Concentrated 0.5ml Progesterone Receptor (BV7) Transforming Growth Factor β3 (TGFβ3) Regulatory Status: RUO Regulatory Status: RUO p504S/α-Methylacyl-CoA Racemase Catalog No.: RMAB028R Concentrated 0.5ml Catalog No.: RP148R Concentrated 1ml (AMACR) RMPD028R Prediluted 6ml RP148-05R Concentrated 0.5ml Regulatory Status: RUO Catalog No.: RP134R Concentrated 1ml Progesterone Receptor (EP2) XRCC1 RP134-05R Concentrated 0.5ml Regulatory Status: RUO Regulatory Status: RUO PDR046R Prediluted 6ml Catalog No.: RMAB052R Concentrated 0.5ml Catalog No.: Mob325R Concentrated 1ml PDR046-10RPR Prediluted 10ml 3 6 0 RMPD052R Prediluted 6ml Mob325-05R Concentrated 0.5ml
p504S/α-Methylacyl-CoA Racemase Progesterone Receptor (PGR-1A6) (AMACR) (13H4) Regulatory Status: RUO Regulatory Status: RUO Catalog No.: Mob103-01R Concentrated 1ml Catalog No.: Mob438R Concentrated 1ml Mob103-01-05R Concentrated 0.5ml Mob438-05R Concentrated 0.5ml PDM025-01R Prediluted 6ml
PIN 5 (Rabbit anti-p40, Mouse Progesterone Receptor (SP2) anti-Cytokeratin H.M.W) + Rabbit Regulatory Status: RUO Catalog No.: RMAB002R Concentrated 0.5ml anti-p504S RMPD002R Prediluted 6ml Regulatory Status: RUO Catalog No.: PDR057R
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Page 136-140 Edit Index Edited.pdf 5 2/17/17 5:09 PM Welcome to Diagnostic BioSystems
Dear Valued Customer,
It has been our pleasure to serve you for 20 years. At Diagnostic BioSystems (DBS) we are committed to enhancing Immunohistochemistry test results at an affordable cost to support pathologists in making increasingly difficult diagnostic decisions.
We invite you to explore the DBS 2017–2018 catalog. We have expanded our portfolio of ultra-sensitive rabbit monoclonal antibodies to provide better decision making tools. Our wide range of chromogens can be used to run multiplex staining across clinical, life science and pharmaceutical industry.
DBS currently engages more than 70 distributors selling the DBS product line around the globe.
We value your business and thank you for considering DBS for your anatomic pathology products.
Sincerely,
Bipin Gupta PhD President & CEO Diagnostic BioSystems
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