DOCSLIB.ORG

Phase 3 Trial of Carboplatin in Triple Negative Breast Cancer (TNBC

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Phase 3 Trial of Carboplatin in Triple Negative Breast Cancer (TNBC Phase 3 Trial of Carboplatin in Triple Negative Breast Cancer (TNBC) Patients with Residual Invasive Carcinoma After Neoadjuvant Chemotherapy (JONIE4:J-CAT Trial) Tanino H, Suzuki M, Kaise H, Miyashita M, Chishima T, Hayashi M, Miyoshi Y, Futamura M, Ohtani S, Nagahashi M, Ohta T, Kosaka Y, Ishikawa T, Hasegawa Y, Kubota T, Sangai T, Iwatani T, Yamada A, Akazawa K, Kohno N. Kobe University, Kobe, Hyogo, Japan; National Hospital Organization Chiba Medical Center, Chiba City, Chiba, Japan; Tokyo Medical University Ibaraki Medical Center, Inashikigun, Ibaraki, Japan; Kohnan Hospital, Kobe, Hyogo, Japan; Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan; Dokkyo Medical University, Mibu, Tochigi, Japan; Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Gifu University, Gifu, Japan; Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan; Niigata University, Niigata, Japan; St. Marianna University School of Medicine, Kawasaki, Knagawa, Japan; Kitasato University, Sagamihara, Kanagawa, Japan; Tokyo Medical University, Shinjuku-ku, Tokyo, Japan; Hirosaki Municipal Hospital, Hirosaki, Aomori, Japan; Kobe Kaisei Hospital, Kobe, Hyogo, Japan; Chiba University Graduate School of Medicine, Chiba, Chiba, Japan; Chigasaki Municipal Hospital, Chigasaki, Kanagawa, Japan; Kamiiida Daiichi General Hospital, Nagoya City, Aichi, Japan. Background: Trial design: Eligibility criteria: This is an open label, randomized phase III study that will enroll TNBC with residual invasive 1) ER and PgR<1%, HER2 0, 1+ or 2+ with FISH negative on core needle biopsy before the It is well known that the prognosis of non pCR TNBC patients was poor after anthracycline chemotherapy and surgical specimens. and taxan treatment. For such patients, capecitabine seems to be effective to reduce cancer after surgery with preoperative chemotherapy including both anthracycrine and taxan. 2) Preoperative chemotherapy including both anthracycrine and taxan. recurrence based on the HR 0.58 of the CREATE X trial (Masuda, N. et al. Adjuvant Patients are randomly assigned to either the carboplatin group or observation group. The Capecitabine for Breast Cancer after Preoperative Chemotherapy. N Engl J Med. 376, 2147. patients in the carboplatin group are treated with carboplatin at AUC 6 and those in the 3) Residual invasive cancer on breast tumors or lymph node metastasis in surgical specimens. observation group are observed at only 3 years. 2017) . However, the target of capecitabine is still unclear for TNBC. We classified non pCR 4) 20-79 year old women. tumors as BRCAness and Sporadic using BRCAness test (MRC-Holland, Amsterdam, the Observation 5) No chemotherapy within 5 years. Netherlands). The recurrence rate of the BRCAness group was about 80%. Carboplatine is Pathology NAC Surgery expected to be effective against BRCAness tumors, as it is a DNA damaging agent. In this Non-pCR R 6) Not bilateral breast cancer, without metastasis, no prior breast cancer. Carboplatin study BRCAness can be checked just before carboplatin treatment using surgical AUC 6 x4 7) No severe bone marrow suppression. specimens. Then the efficacy of carboplatin will be directly known to make comparison Specific aims: between DFS in the carboplatin group and that of the observation group. Primary objective is DFS (Disease Free Survival). STATISTICAL METHODS: Secondary objectives are overall survival and safety. The 3 years recurrence rate of the observation group was estimated as 40% and hazard ratio at The prognosis of non pCR TNBC patients was poor after anthracycline and taxan treatment. P6-09-06 BRCAness as a prognostic marker in 0.58 based on the CREATE X trial. For both groups, 135 patients are necessary. This study is triple-negative breast cancer patients treated with powered to approximately 80% to test the superiority of carboplatin group at a 2-sided α=0.05 neoadjuvant chemotherapy: a multicenter retrospective using a stratified log-rank test. Study. Y Kosaka, H.Tanino et al 2018 SABCS (Sat. 8th Dec.) Recurrence Free Survival Overall Survival (%) (%) 100 100 non-BRCAness (n=30) 80 non-BRCAness (n=30) 80 Activation Date: 22nd March 2018. 60 60 Contact information for people with a specific interest in the trial: 40 40 BRCAness (n=19) H. Tanino MD, PhD, Department of Breast Surgery, Kobe University, 7-5-2 Kusunoki-cho, Chuo- 20 20 BRCAness (n=19) ku, Kobe, Hyogo, 650-0017 Japan p < 0.01 p < 0.05 0 20 40 60 80 0 20 40 60 80 Cortazar P et al Lancet 2014 Time (months) Time (months).
Load more

Recommended publications
  • SAITAMA, JAPAN Just North of Tokyo Nature, Koedo, Shopping and Events
    Crayon Shin-chan There's plenty to see! © U/ F・S・A・A , Saitama Sightseeing Supporter SAITAMA, JAPAN Just North of Tokyo Nature, Koedo, shopping and events Chichibu & North Area West Area Central & East Area Crayon Shin-chan © U/ F・S・A・A , Saitama Sightseeing Supporter Tourism Division, Department of Industry and Labor, Saitama Prefecture ※Some of the facilities shown in this brochure may be temporarily closed, or their hours may be changed due to COVID-19. Please also note that events and festivals may either be delayed or canceled. Thank you for understanding. Visit Saitama Prefecture, where you can experience the past and present of Japan! The Chichibu Area and North Area are full of the appeal of richGUMMA nature, the West Area is where you can feel the atmosphere of Japan, and the Central Area and East Area are a fusion of city and nature. Experience Japanese history and culture in Saitama Prefecture, which is full of attractions! Fujioka IC Fujioka JCT y a w Tobu Nikko Line s e s pr x Joetsu Shinkansen/Hokuriku Shinkansen E 17 u k o Chichibu & North Area h o Chichibu Area and the North Area are full of excitement. T Refresh the soul in magnifi cent natural beauty of Chichibu and T o Hanyu IC b Nagatoro, and taste local dishes of the North Area that have Gyodashi u Ise Sta. s → FOR ak been developed independently. Tohoku Shinkansen 140 125 i L Kazo IC Narita Kumagaya Sta.Takasaki Line ine Airport Hanazono IC H a c Nagatoro Sta. h Kan-etsu ik o L Expressway y ine Kuki a w Shiraoka- l IC Mandarin orange i a Ogawamachi Sta.
    [Show full text]
  • Chiba Universitychiba
    CHIBA UNIVERSITY CHIBA 2019 2020 2019 CHIBA UNIVERSITY 2019 2019-2020 Contents 01 Introduction 01-1 A Message from the President ................................................................................................. 3 01-2 Chiba University Charter ........................................................................................................... 4 01-3 Chiba University Vision ............................................................................................................... 6 01-4 Chiba University Facts at a Glance .......................................................................................... 8 02 Topic 02-1 Institute for Global Prominent Research ............................................................................... 11 02-2 Chiba Iodine Resource Innovation Center (CIRIC) ............................................................. 12 02-3 Enhanced Network for Global Innovative Education —ENGINE— ................................. 13 02-4 Top Global University Project .................................................................................................. 14 02-5 Inter-University Exchange Project .......................................................................................... 15 02-6 Frontier Science Program Early Enrollment ........................................................................ 16 02-7 Honey Bee Project ....................................................................................................................... 18 02-8 Inohana Campus High
    [Show full text]
  • Saitama Prefecture 埼玉県
    February 2017 Saitama Prefecture 埼玉県 一 1 Overview of Saitama Pref.埼 2 Fiscal Position 玉 3 Bond Issue Policies 県 勢 Mt.Buko Kawagoe Bell Tower Saitama Shintoshin Saitama Super Arena Saitama Stadium 2002 Sakitama Ancient Burial Mounds “Toki-no-kane” “Sakitama Kohun-gun” 1 Overview of Saitama Population, Industry, Transportation and Rising Potential Population of 7.3 million equal to that of Switzerland・・・Relatively lower average age and larger productive age population ratio than other prefectures A variety of industries generate nominal GDP worth JPY21trn, equal to that of Czech and New Zealand Hokkaido Convenient transportation network and lower disaster risks Prefectural Gross Product (Nominal) Population 7.27mn (#5) Akita Source: 2015 National Census JPY20.7trn(#5) Source: FY2013 Annual Report on Prefectural Accounts, Cabinet Office １ Tokyo Metro. 13,520,000 １ Tokyo Metro. JPY93.1trn Yamagata ２ Kanagawa Pref. 9,130,000 ２ Osaka Pref. JPY37.3trn ３ Osaka Pref. 8,840,000 ３ Aichi Pref. JPY35.4trn ４ Aichi Pref. 7,480,000 ４ Kanagawa Pref. JPY30.2trn ５ Saitama Pref. 7,270,000 ５ Saitama Pref. JPY20.7trn Population Growth 1.0%(#3) Hokuriku oban Metropolitan Employer compensation Inter-City per capita Kyoto Saitama Expressway Nagoya Tokyo Gaikan Tokyo Expressway JPY4,620,000(#7) Osaka Narita Source: FY2013 Annual Report on Prefectural Accounts, Cabinet Haneda Office Expressway Japan Shinkansen Japan’s Key Transportation Hub Lower Risk of Natural Disaster ・Connected to major eastern Japan cities with 6 Shinkansen lines Estimated damage on buildings
    [Show full text]
  • UCLA Japan Center Opened in Kashiwa-No-Ha (Kashiwa City, Chiba) ======Tokyo, Japan, June 20 2016,Mitsui Fudosan Co., Ltd
    Press release June 20, 2016 Mitsui Fudosan Co., Ltd. UCLA (University of California, Los Angeles) =========================================================================================== UCLA Japan Center Opened in Kashiwa-no-ha (Kashiwa City, Chiba) =========================================================================================== Tokyo, Japan, June 20 2016,Mitsui Fudosan Co., Ltd. and UCLA (University of California, Los Angeles) announced the opening of the UCLA Japan Center in Mitsui Fudosan’s “31VENTURES KOIL” in Kashiwa-no-ha Smart City, which promotes urban development through public-private-academic partnership. On June 16, UCLA Chancellor Gene Block and related personnel arrived in Japan and after holding discussions with urban development personnel at Kashiwa-no-ha Smart City, held an inaugural reception. The UCLA Japan Center was founded as a memorial project for the 100th anniversary of UCLA in 2019 and will serve as a point of contact for UCLA in Japan, a Japan Alumni Association office and a Japan base for UCLA researchers. UCLA chose this location because it endorses Kashiwa-no-ha Smart City’s concept of urban development to create problem-solving models for the world and 31VENTURES KOIL’s concept of business creation through open innovation, both based on public-private-academic partnership. With such a location as the stage, a major goal of the center is to be a base of exchange that contributes to enhancing international relations between Japan and the rest of Asia as well as the U.S. and promoting mutual
    [Show full text]
  • Doro-Chiba Quake Report
    Doro-Chiba Quake Report April 20, 2011/ issue 14 International Labor Solidarity Committee of Doro-Chiba (National Railway Motive Power Union of Chiba) Anger, fight and unity! We are striving to live” Let’s organize a powerful movement against dismissal under the pretext of the quake and to stop nuclear plant Report from the Secratariat of the People’s Earthquake Relief Center on their visit to Sendai one month after the earthquake April 18, 2011 From April 11 to 12, just a month after the huge earthquake, we, secretariat of PERC, visited the Relief Center located in Sendai City. We reached there via Fukushima by a truck fully loaded with relief goods. Violent aftershock repeatedly attacked us during we talked with our suffering friends there. We were shown Shiogama port, Sendai port and its surrounding areas and Yuriage district of Natori City, most terribly stricken by the quake. Life and death battle still continues in the affected areas Near the Port of Sendai, we saw only heaps of wreckages of houses, cars… What struck us the most was the serious fact that affected areas are still faced with the matter of life and death even a month after the disaster, far from restoration. It is evidently impossible to live without fighting. The center part of Sendai with one million inhabitants certainly seems to have recovered to a certain degree. But in the coast region of the city, we shockingly witnessed a totally different picture: wreckages by the huge quake and the subsequent gigantic tsunami are scattered all over the area, such as crushed cars heaped up like toys, shapeless debris of houses, washed up big ships, etc.
    [Show full text]
  • Welcome to Kashiwa Campus the University of Tokyo
    Welcome to Kashiwa Campus The University of Tokyo Adventures in Knowledge Kashiwa Campus is the newest of the three main campuses of The University of Tokyo in addition to campuses at Hongo and Komaba, and was established with the vision of building a new community with a strong interdisciplinary and international character that can respond to the dynamic scientific and educational needs of the 21st Century. Hongo Campus, the core of traditional academic activities at The University of Tokyo since its foundation in 1877, and Komaba Campus, focusing on undergraduate studies and building interdisciplinary links between established fields of study for over 60 years, have longstanding academic traditions. Kashiwa Campus recently joined this family and aims at a fundamental reorganization of the structure of traditional academic disciplines, reconsidering the framework of how knowledge is created and organized. Under the slogan of “Adventures in Knowledge”, Kashiwa Campus has started various new initiatives. The Graduate School of Frontier Sciences (GSFS) consists of three divisions each with relevant departments: Division of Transdisciplinary Sciences, Division of Biosciences, and Division of Environmental Studies. GSFS aims to create new frontiers of academic fields. The Institute for Solid State Physics (ISSP) is exploring a wide variety of phenomena exhibited by various materials from the viewpoint of basic science using state-of-art experimental facilities and techniques. Materials under study include those forming the basis of today's high-tech society and its future development. The Institute for Cosmic Ray Research (ICRR) is pursuing the origins of the universe and matter through research on cosmic rays. The Atmosphere and Ocean Research Institute (AORI) not only promotes basic research on the ocean and atmosphere, but also contributes to society through deepening ocean and climate science.
    [Show full text]
  • Chiba Prefecture (Chiba City)
    dogawa ard Map Number Restaurant name Category Page 1. asai Canoe lalom Centre 11 1 ・ ・ ・ KAGAYA apanese ・ ・ ・ P.1 Chiba Prefecture Chiba City ・・・・・・・・・・・・・・・・・・・ . akuhari esse all A 11 1 ・ ・ ・ hiomachi aryo ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ apanese ・ ・ ・ P.1 . akuhari esse all 11 1 ・ ・ ・ ICO ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ Western ・ ・ ・ P.1 1 ・ ・ ・ bills ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ Western ・ ・ ・ P.1 Ota ard 1 ・ ・ ・ Yoshidaya ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ apanese ・ ・ ・ P.1 1. Oi ockey tadium ・ ・ ・ ea ind ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ Western ・ ・ ・ P.11 inato ard Daiba oto ard oto ard atsumi Yumenoshima omi hinagawa ard ・ ・ ・ OICI Coffee ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ Cafe ・ ・ ・ P.11 . Yumenoshima Park rchery ield 1. Odaiba arine Park . Tokyo uatics Centre ・ ・ ・ SAI ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ Western ・ ・ ・ P.11 1. hiokae Park . Tatsumi ater Polo Centre 1. omi rban ports Park ・ ・ ・ CI I ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ Western ・ ・ ・ P.11 19. ea orest Cross-Country Course oto ard riake ・ ・ ・ IO YSER ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ Western ・ ・ ・ P.11 . ea orest aterway 11. riake rena . hinagawa tation 1. riake ymnastics Centre ・ ・ ・ TO O ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ Western ・ ・ ・ P.1 1. riake rban ports Park H ・ ・ ・ Tsubame rill ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ ・ Western ・ ・ ・ P.1 1. riake Tennis Park Opening hours, regular holidays, number of seats, etc. may differ from those listed due to the effects of COVID-19. Please check with the store in advance when you visit. 96 97 Checklist
    [Show full text]
  • Chiba City & Houston
    SISTER CITIES Chiba City & Houston Chiba City Logo This year marks the 30th anniversary of a to ask about partnering with a Japanese city • Baseball games between little league teams sister-city agreement between Chiba City, with similar interests and characteristics. Chiba from the two cities Japan and the City of Houston, USA. City recognized that it had many commonali- Festivities celebrating the event were held this ties with Houston. Both are port cities with • An agreement starting in 1990 between the past July in Houston. The mayor of Chiba strong industrial bases. Chiba accepted the University of Houston’s College of Business City, Keiichi Tsuruoka, led the visiting offer and after a short but fruitful courtship, Administration and Chiba University’s Japanese delegation which also included the cities completed a sister-city agreement on Faculty of Law and Economics for joint Hiroshi Ichihara, Chairman of the Chiba City October 24, 1972. research studies and faculty and student Municipal Assembly, and members represent- exchanges ing the public, private and academic sectors. The 30 year relationship has continuously deepened, and has been punctuated by numer- Mayor Tsuruoka, Chairman Chiba City, the capital of Ichihara and the Japanese Chiba Prefecture, is located on anniversary delegation met with the Boso Peninsula, approximate- Houston Mayor Lee Brown in his ly 40km (25 mi) east of Tokyo. office at City Hall last July. After Blessed with a moderate climate, the meeting, commemorative the city has grown recently, and photographs were taken and the its population now exceeds City of Houston hosted a public 900,000; as a result, in April of anniversary celebration during 1992 Chiba was named a “desig- which the two mayors spoke and nated city.” Chiba has an interna- exchanged gifts.
    [Show full text]
  • Chiba Travel
    ChibaMeguri_sideB Leisure Shopping Nature History&Festival Tobu Noda Line Travel All Around Chiba ChibaExpressway Joban Travel Map MAP-H MAP-H Noda City Tateyama Family Park Narita Dream Farm MITSUI OUTLET PARK KISARAZU SHISUI PREMIUM OUTLET® MAP-15 MAP-24 Express Tsukuba Isumi Railway Naritasan Shinshoji Temple Noda-shi 18 MAP-1 MAP-2 Kashiwa IC 7 M22 Just within a stone’s throw from Tokyo by the Aqua Line, Nagareyama City Kozaki IC M24 Sawara Nagareyama IC Narita Line 25 Abiko Kozaki Town why don’t you visit and enjoy Chiba. Kashiwa 26 Sawara-katori IC Nagareyama M1 Abiko City Shimosa IC Whether it is for having fun, soak in our rich hot springs, RyutetsuNagareyamaline H 13 Kashiwa City Sakae Town Tobu Noda Line Minami Nagareyama Joban Line satiate your taste bud with superior products from the seas 6 F Narita City Taiei IC Tobu Toll Road Katori City Narita Line Shin-Matsudo Inzai City Taiei JCT Shiroi City Tonosho Town and mountains, Chiba New Town M20 Shin-Yahashira Tokyo Outer Ring Road Higashikanto Expressway Hokuso Line Shibayama Railway Matsudo City Inba-Nichi-idai Narita Sky Access Shin-Kamagaya 24 you can enjoy all in Chiba. Narita Narita Airport Tako Town Tone Kamome Ohashi Toll Road 28 34 Narita IC Musashino Line I Shibayama-Chiyoda Activities such as milking cows or making KamagayaShin Keisei City Line M2 All these conveniences can only be found in Chiba. Naritasan Shinshoji Temple is the main temple Narita International Airport Asahi City butter can be experienced on a daily basis. Narita Line Tomisato IC Ichikawa City Yachiyo City of the Shingon Sect of Chizan-ha Buddhism, Funabashi City Keisei-Sakura Shisui IC You can enjoy gathering poppy , gerbera, Additionally, there are various amusement DATA 398, Nakajima, Kisarazu-City DATA 689 Iizumi, Shisui-Town Sobu LineKeisei-Yawata Shibayama Town M21 Choshi City Isumi and Kominato railroad lines consecutively run across Boso Peninsula, through a historical Choshi 32 and antirrhinum all the year round in the TEL:0438-38-6100 TEL:043-481-6160 which was established in 940.
    [Show full text]
  • Hours: (Varies Depending on Seasons)
    Symbolic mascot “Donchan・Gurichan” of Forest and Park for the 21st Century Hours: (varies depending on seasons) 9:00 am～5:00pm (9:00 am to 6:30 pm between July 21 and August 20 9:00 am to 4:30 pm between November 1 and end of February) *Closed on: December 30 to January 1 You are requested to return this guidebook at the gate when leaving the park. —Foreword— Thank you for your coming to Forest and Park for the 21st Century. This park was opened on April 29, 1993 as a “Respect Nature Style Urban Park”. As the word “Respect nature” indicates, we operate the park based on the keynote that we will protect and grow the valuable nature that still exists in the Matsudo Sendabori district. As one of the ways to protect the nature from harm, we have to ask the visitors to kindly take their litter home with them. We would appreciate your further understanding and cooperation to the following requests. —Requests— There are some rules for visitors’ safe and comfortable use of the park as below. The following are forbidden: Playing golf, baseball and soccer, dangerous play like radio-controlled toys, bringing in of dangerous goods, using of fire (excluding barbecue site), using of bicycles (including kickboards), bringing in of pets, setting up of tents, fishing (fishing of crayfish by kite strings is allowed, but not by nylon fishing guts). Picking the plants and catching the animals are prohibited (excluding crayfish), and feeding the birds, fish and other living creatures are also prohibited.
    [Show full text]
  • 2030Saitama Bright Future and Hopeful City Plan
    2030Saitama Bright Future and Hopeful City Plan Saitama City Comprehensive Development Plan Basic Plan 2021 — 2030 Summary Components of the 2030 Saitama Bright Future and Hopeful City Plan The basic plan in the Saitama City Comprehensive Development Plan (2030 Saitama Bright Future and Hopeful City Plan) comprises five parts: Part 1 “Toward a New City Development”, Part 2 “Components and Promotion of the Plan”, Part 3 “Policy and Measures in Each of the Fields”, Part 4 “Characteristics and Future Images of Each Ward” and Part 5 “Implementation of Quality City Management”. This summary compiles and outlines the content. Historical Development of Saitama City Start-up phase (May 2001 to 2005) Once the cities of Urawa, Omiya and Yono had been amalgamated in May 2001 and followed their transition to a designated city, Saitama City was amal- gamated with the city of Iwatsuki in April 2005. To ensure the city would be seamlessly integrated on board right after, well-balanced regional development and civil welfare improvement, Saitama City promoted its city development fur- ther to create the identity of the city based on the “New City Development Plan”. Growth phase (FY 2006 to 2013) Amid the economic recession caused by the global financial crisis in 2008 and the Great East Japan Earthquake in 2011, Saitama City initiated its city develop- ment as part of efforts to reinvent its future image along the lines of the “Saitama Hopeful City Plan”, which was established in March 2004 (and subsequently revised in January 2006). The “Financial and Administrative Reform Promotion Plan 2010” was also established to initiate financial and administrative reform.
    [Show full text]
  • Than a Smart City: Kashiwa-No-Ha Is Healthy, Efficient and Innovative
    article More than a Smart City: Kashiwa-no-ha is Healthy, Efficient and Innovative Streetscape of Kashiwa-no-ha. Written by An ultra-ageing society and a stagnant economy were some of the See Boon Ping contemporary urban challenges that led to the birth of Kashiwa-no-ha Smart City ( ). During the turn of the millennium, the 柏の 葉 スマートシティ Chiba Prefecture Government initiated this 273ha1 development at the 1. Kashiwa-no-ha Urban northern part of Kashiwa City ( ) to create a collaborative platform that Planning and Development 柏市 could transform the area formerly occupied by the United States Air Force Department, Mitsui 2 Fudosan Co Ltd (2014). Communication Base and Mitsui Fudosan’s Kashiwa Golf Club. A New Vision for the Cities of Tomorrow, Second Edition. Over the last decade, the city has brought together various stakeholders, 2. https://www. including the public sector (i.e. the Chiba Prefecture Government and kashiwanoha-smartcity. the Kashiwa City Government), the private sector (e.g. Mitsui Fudosan, com/en/concept/ Metropolitan Intercity Railway Company, etc.), academia (i.e. the University of history.html (accessed 28 December 2018). Tokyo and the Chiba University) and non-profit organisations to create a next- generation city for its population of 4,1243 that is projected to grow to 26,000 3. http://www.city.kashiwa. eventually. A key player is the Urban Design Center Kashiwa-no-ha (UDCK), lg.jp/soshiki/020800/ p009116.html (accessed an independent organisation formed, managed and funded by the different 28 December 2018). partners. It functions as a research think-tank, collaboration coordinator, 1 Kashiwa-no-ha is 25 km away from Downtown Tokyo, and is accessible by a 23-min train ride from Akihabara Station (in Downtown Tokyo) via the Tsukuba Express.
    [Show full text]