Anti-AIFM1 Monoclonal Antibody, Clone 5F8 (DCABH-10467) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-AIFM1 monoclonal antibody, clone 5F8 (DCABH-10467) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene.

Immunogen Recombinant protein corresponding to human AIFM1.

Isotype IgG2b

Source/Host Mouse

Species Reactivity Human, Monkey, Mouse, Rat

Clone 5F8

Conjugate Unconjugated

Applications Western Blot (Cell lysate); Western Blot (Recombinant protein); Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections); Immunofluorescence; ELISA; Flow Cytometry

Format Liquid

Size 1 ea

Buffer In ascites (0.03% sodium azide)

Preservative 0.03% Sodium Azide

Storage Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.

Warnings This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 [ Homo sapiens ]

Official Symbol AIFM1

Synonyms AIFM1; apoptosis-inducing factor, mitochondrion-associated, 1; PDCD8, programmed cell death 8 (apoptosis inducing factor); apoptosis-inducing factor 1, mitochondrial; AIF; striatal apoptosis- inducing factor; programmed cell death 8 (apoptosis-inducing factor); PDCD8; COXPD6; MGC111425;

Entrez Gene ID 9131

Protein Refseq NP_001124318

UniProt ID O95831

Chromosome Location Xq26.1

Pathway Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis Modulation by HSP70, organism-specific biosystem; Ceramide signaling pathway, organism-specific biosystem;

Function DNA binding; electron carrier activity; flavin adenine dinucleotide binding; oxidoreductase activity; protein binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]