Anti-MCC Antibody (ARG55035)

Product datasheet [email protected]

ARG55035 Package: 100 μl anti-MCC antibody Store at: -20°C

Summary

Product Description Rabbit Polyclonal antibody recognizes MCC

Tested Reactivity Hu, Ms

Tested Application WB

Host Rabbit

Clonality Polyclonal

Isotype IgG

Target Name MCC

Antigen Species Human

Immunogen Recombinant protein of Human MCC (NP_001078846.1)

Conjugation Un-conjugated

Alternate Names MCC1; Protein MCC; Colorectal mutant cancer protein

Application Instructions

Application table Application Dilution

WB 1:200 - 1:2000

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Positive Control Mouse liver

Calculated Mw 93 kDa

Properties

Form Liquid

Purification Affinity purification with immunogen.

Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol

Preservative 0.02% Sodium azide

Stabilizer 50% Glycerol

Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.

Note For laboratory research only, not for drug, diagnostic or other use.

www.arigobio.com 1/2 Bioinformation

Database links GeneID: 4163 Human

Swiss-port # P23508 Human

Gene Symbol MCC

Gene Full Name mutated in colorectal cancers

Background This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b- catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. [UniProt]

Research Area Cancer antibody

Images

ARG55035 anti-MCC antibody WB image

Western blot: Mouse liver lysate stained with ARG55035 anti-MCC antibody.