Program and Speakers

8:30 a.m. Registration Opens 9:00 a.m. Welcome Remarks and Press Sri Narasimhan Marie Bao, 9:05 a.m. Lgr5+ -based organoids and their applications Hans Clevers, Hubrecht Institute, the Netherlands 9:45 a.m. A systems biology approach to investigate cell fate in intestinal organoids

Michiel Vermeulen, Radboud University, Nijmegen, the Netherlands

10:10 a.m. Regeneration of the gut with IL-22 Caroline Lindemans, University Medical Center Utrecht, the Netherlands 10:35 a.m. Tea and Coffee (Trippenhuis) 10:55 a.m. Phenotypic heterogeneity in tumor organoids The Organoid Hugo Snippert, University Medical Center Utrecht, the Netherlands Revolution: 11:20 a.m. Glandular organoids for the regeneration of radiation damaged tissues Organs in a Dish Rob Coppes, University Medical Center Utrecht, the Netherlands 11:55 a.m. Lunch (on your own) Tuesday, September 27, 2016 9:00 a.m. – 5:00 p.m. 1:00 p.m. and Pancreas organoid cultures Meritxell Huch, Gurdon Institute, Cambridge, UK Trippenhuis, The Royal Netherlands Academy of 1:45 p.m. The role of Bcl2 family members in colon Arts and Sciences. Amsterdam, the Netherlands stem cells Jan Paul Medema, Academic Medical Center Organizers Amsterdam, the Netherlands Marie Bao 2:10 p.m. Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer Editor, Developmental Cell organoids Jacco Van Rheenen, Gurdon Institute, Cambridge, Hans Clevers UK Hubrecht Institute, the Netherlands 2:35 p.m. Clinical translation of tumor organoids Fleur Weeber, Netherlands Cancer Institute, the Sri Devi Narasimhan Netherlands Scientific Editor, Cell 3:00 p.m. Tea and Coffee (Trippenhuis) 3:30 p.m. Personalising using intestinal Hugo Snippert organoids University Medical Center Utrecht, the Netherlands Jeff Beekman, University Medical Center Utrecht, the Netherlands To register, go to: 3:55 p.m. Primary organoid cultures to dissect the role of Wnt signaling in mammary gland biology and breast http://www.cell.com/lablinks cancer Registration is FREE (space is limited) Renee Van Amerongen, University of Amsterdam, the Netherlands 4:20 p.m. Modeling human development and disease in This meeting will bring together leaders who stem cell derived 3D organoid culture Juergen Knoblich, Institute of Molecular Biology, are making fundamental strides towards Vienna, Austria understanding organoids. The meeting 5:00 p.m. Closing Remarks and , Cell Press will also address the exciting implications Sri Narasimhan Marie Bao organoids have for regenerative and 6:30 p.m. Speakers' Dinner (By invitation only) personalized medicine while highlighting challenges that need to be addressed in this context. Short-format talks will promote discussion and provide an excellent opportunity for local labs to interact. Sponsored by