Epidermal Tumors
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Glossary for Narrative Writing
Periodontal Assessment and Treatment Planning Gingival description Color: o pink o erythematous o cyanotic o racial pigmentation o metallic pigmentation o uniformity Contour: o recession o clefts o enlarged papillae o cratered papillae o blunted papillae o highly rolled o bulbous o knife-edged o scalloped o stippled Consistency: o firm o edematous o hyperplastic o fibrotic Band of gingiva: o amount o quality o location o treatability Bleeding tendency: o sulcus base, lining o gingival margins Suppuration Sinus tract formation Pocket depths Pseudopockets Frena Pain Other pathology Dental Description Defective restorations: o overhangs o open contacts o poor contours Fractured cusps 1 ww.links2success.biz [email protected] 914-303-6464 Caries Deposits: o Type . plaque . calculus . stain . matera alba o Location . supragingival . subgingival o Severity . mild . moderate . severe Wear facets Percussion sensitivity Tooth vitality Attrition, erosion, abrasion Occlusal plane level Occlusion findings Furcations Mobility Fremitus Radiographic findings Film dates Crown:root ratio Amount of bone loss o horizontal; vertical o localized; generalized Root length and shape Overhangs Bulbous crowns Fenestrations Dehiscences Tooth resorption Retained root tips Impacted teeth Root proximities Tilted teeth Radiolucencies/opacities Etiologic factors Local: o plaque o calculus o overhangs 2 ww.links2success.biz [email protected] 914-303-6464 o orthodontic apparatus o open margins o open contacts o improper -
Systematized Verrucous Epidermal Nevus- a Case Report
Jebmh.com Case Report Systematized Verrucous Epidermal Nevus- A Case Report B.C. Sharathkumar1, N.S. Anitha2 1Professor and HOD, Department of Dermatology, Venereology and Leprosy, Kempegowda Institute of Medical Sciences Hospital and Research Centre, Bengaluru, Karnataka. 2Resident, Department of Dermatology, Venereology and Leprosy, Kempegowda Institute of Medical Sciences Hospital and Research Centre, Bengaluru, Karnataka. INTRODUCTION Veracious epidermal nevus (VEN) is a keratinocyte hematoma, usually present at Corresponding Author: birth or can develop later in life.1,2 It commonly involves trunk and limbs. Less Dr. N. S. Anitha, Resident, commonly, involved sites are head and neck; face is known to involve even more Department of Dermatology, 3,4,5 rarely. Clinical variants of VEN are zosteriform, linear, unilateral or systematized Venereology and Leprosy, 6 patterns with streaks and swirls. We report a case of girl who presented with Kempegowda Institute of Medical extensive VEN causing a lot of disfigurement. Epidermal nevi are hamartomas of Sciences Hospital and Research Centre, cutaneous structures arising from the embryonic ectoderm. The prevalence rate is Bengaluru- 560004, Karnataka. 1 in 1000, without predilection to race and sex.7,8 They are further divided into E-mail: [email protected] nonorganoid (Keratinocytic) types and organoid types (due to hyperplasia of DOI: 10.18410/jebmh/2019/637 adnexal structures such as sebaceous glands, sweat glands and hair follicles).8,9 Financial or Other Competing Interests: All epidermal nevi represents disorder of dermo-epidermal interactions and most None. cases are sporadic. Verrucous epidermal nevus is the most common type of keratinocyte nevus and derives its name from its keratotic and warty appearance. -
Multiple Asymptomatic Papules on the Back of the Right Side of the Chest Angoori Gnaneshwar Rao
QUIZ Multiple Asymptomatic Papules on the Back of the Right Side of the Chest Angoori Gnaneshwar Rao A 43-year-old male presented with multiple asymptomatic complete blood picture, blood sugar, complete urine examination, papules on the back of the right side of the chest of 1 year blood urea, serum creatinine, liver function tests and serum duration. He was asymptomatic a year back then he developed lipid profile were normal. Fundus was normal. A slit skin smear small papules on the right side of the front of the chest initially for acid fast bacilli was negative. A punch biopsy from the and later on involved the front and back of the chest. No representative lesion subjected to histopathological examination history was suggestive of leprosy and hyperlipidemias. Family revealed a cyst with an intricately folded wall, lined by two to history was negative for similar problem. Examination revealed three layers of flattened squamous epithelium and the absence multiple skin-colored to yellowish papules distributed on the of the granular layer. Lobules of sebaceous glands were found front and back of the chest and shoulder region on the right embedded in cyst lining. The lumen was filled with amorphous side [Figure 1]. Also, there were multiple hyperpigmented eosinophilic material and multiple hair shafts [Figures 2-4]. macules on the right infrascapular region. There was no nerve thickening and no sensory deficit and there were no Question hypopigmented or anesthetic patches. Systemic examination did not reveal any abnormality. Routine investigations including What is your diagnosis? (Original) Multiple skin-colored to yellowish papules on the back of chest Figure 1: Figure 2: (Original) Histopathology of skin showing a cyst with an intricately folded and shoulder region on the right side wall lined by two to three layers of flattened squamous epithelium and the absence of granular layer. -
Atypical Compound Nevus Arising in Mature Cystic Ovarian Teratoma
J Cutan Pathol 2005: 32: 71–123 Copyright # Blackwell Munksgaard 2005 Blackwell Munksgaard. Printed in Denmark Journal of Cutaneous Pathology Abstracts of the Papers Presented at the 41st Annual Meeting of The American Society of Dermatopathology Westin Copley Place Boston, Massachusetts, USA October 14–17, 2004 These abstracts were presented in oral or poster format at the 41st Annual Meeting of The American Society of Dermatopathology on October 14–17, 2004. They are listed on the following pages in alphabetical order by the first author’s last name. 71 Abstracts IN SITU HYBRIDIZATION IS A VALUABLE DIAGNOSTIC A 37-year-old woman with diagnosis of Sjogren’s syndrome (SS) TOOL IN CUTANEOUS DEEP FUNGAL INFECTIONS presented with asymptomatic non-palpable purpura of the lower J.J. Abbott1, K.L. Hamacher2,A.G.Bridges2 and I. Ahmed1,2 extremities. Biopsy of a purpuric macule revealed a perivascular Departments of Laboratory Medicine and Pathology1 and and focally nodular lymphocytic infiltrate with large numbers of Dermatology2, plasma cells, seemingly around eccrine glands. There was no vascu- litis. The histologic findings in the skin were strikingly similar to those Mayo Clinic and Mayo Foundation, Rochester, MN, USA of salivary, parotid, and other ‘‘secretory’’ glands affected in SS. The cutaneous manifestations of SS highlighted in textbooks include Dimorphic fungal infections (histoplasmosis, blastomycosis, coccidiomy- xerosis, annular erythema, small-vessel vasculitis, and pigmented cosis, and cryptococcosis) can occur in immunocompromised and purpura. This case illustrates that purpura in skin of patients with healthy individuals. Cutaneous involvement is often secondary and SS may be caused by a peri-eccrine plasma-rich infiltrate. -
Morphologic Diversity in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma: Catch Me If You Can! James S Lewis Jr
Modern Pathology (2017) 30, S44–S53 S44 © 2017 USCAP, Inc All rights reserved 0893-3952/17 $32.00 Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can! James S Lewis Jr Department of Pathology, Microbiology, and Immunology; Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, TN, USA As the human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma epidemic has developed in the past several decades, it has become clear that these tumors have a wide variety of morphologic tumor types and features. For the practicing pathologist, it is critical to have a working knowledge about these in order to make the correct diagnosis, not to confuse them with other lesions, and to counsel clinicians and patients on their significance (or lack of significance) for treatment and outcomes. In particular, there are a number of pitfalls and peculiarities regarding HPV-related tumors and their nodal metastases that can easily result in misclassification and confusion. This article will discuss the various morphologic types and features of HPV- related oropharyngeal carcinomas, specific differential diagnoses when challenging, and, if established, the clinical significance of each finding. Modern Pathology (2017) 30, S44–S53; doi:10.1038/modpathol.2016.152 It is now well-established that human papilloma- Among its many effects on clinical practice, the virus (HPV) is responsible for a large fraction of oropharyngeal HPV epidemic has put pathologists at oropharyngeal squamous cell carcinomas (SCC), the forefront of diagnosis and recognition of these particularly in the United States and Europe.1 Many unique tumors, which are much less clinically have termed the increase in HPV-related orophar- aggressive than conventional head and neck SCC, 7 yngeal SCC as an epidemic.2,3 There are numerous and which are beginning to be managed differently. -
Genomic Landscape of a Metastatic Malignant Proliferating Tricholemmal Tumor and Its Response to PI3K Inhibition
www.nature.com/npjprecisiononcology CASE REPORT OPEN Genomic landscape of a metastatic malignant proliferating tricholemmal tumor and its response to PI3K inhibition Jean-Nicolas Gallant1, Andrew Sewell2,8, Karinna Almodovar1, Qingguo Wang3,9, Kimberly B. Dahlman1, Richard G. Abramson4, Meghan E. Kapp5, Brandee T. Brown2, Kelli L. Boyd5, Jill Gilbert1, Daniel N. Cohen5,10, Wendell G. Yarbrough2,9,6, Zhongming Zhao 3,7,11 and Christine M. Lovly1,7 Proliferating tricholemmal tumors (PTTs) are rare benign neoplasms that arise from the outer sheath of a hair follicle. Occasionally, these PTTs undergo malignant transformation to become malignant proliferating tricholemmal tumors (MPTTs). Little is known about the molecular alterations, malignant progression, and management of MPTTs. Here, we describe the case of a 58-year-old female that had a widely metastatic MPTT that harbored an activating PIK3CA mutation and was sensitive to the PI3K inhibitor, alpelisib (BYL719). We review the available literature on metastatic MPTT, detail the patient’s course, and present a whole genome analysis of this rare tumor. npj Precision Oncology (2019) 3:5 ; https://doi.org/10.1038/s41698-019-0077-2 INTRODUCTION posterior scalp cyst for cosmesis. This non-inflamed, non-draining, Proliferating tricholemmal tumors (PTTs) are benign neoplasms of painless, 1–2 cm cyst had been present for close to 10 years the external hair sheath.1 PTTs have the potential for malignant without change in size or fluctuance. The cyst was initially drained transformation, and, when characterized by cytologic atypia, by the PCP, but, when it recurred 6 months later, the PCP excised abnormal mitoses, and infiltrating margins, are termed malignant the cyst and sent the specimen for routine pathology. -
Dermatologists' Perceptions on the Utility and Limitations
RESEARCH/Original Article Journal of Telemedicine and Telecare 2021, Vol. 27(3) 166–173 Dermatologists’ perceptions on the ! The Author(s) 2019 utility and limitations of teledermatology Article reuse guidelines: sagepub.com/journals-permissions after examining 55,000 lesions DOI: 10.1177/1357633X19864829 journals.sagepub.com/home/jtt Mara Giavina Bianchi , Andre Santos and Eduardo Cordioli Abstract Introduction: Few studies have assessed the perception of teledermatologists about the utility and limitations of teledermatology, especially to diagnose a broad range of skin diseases. This study aimed to evaluate dermatologists’ confidence in teledermatology, its utility and limitations for dermatological conditions in primary care. Methods: An analytical study that used a survey for dermatologists who diagnosed 30,916 patients with 55,012 lesions through teledermatology during a 1-year project in S~ao Paulo, Brazil. Results: Dermatologists found teledermatology useful for triage and diagnosis, especially for xerotic eczema, pigmen- tary disorders and superficial infections. Their confidence in teledermatology was statistically higher by the end of the project (p ¼ 0.0012). Limitations included some technical issues and the impossibility to suggest how soon the patient should be assisted face-to-face by a dermatologist. The most treatable group of diseases by teledermatology was superficial infections (92%). The use of dermoscopy images would significantly increase the confidence to treat atypical naevi and malignant tumours (p < 0.0001 and p ¼ 0.0003 respectively). Follow-ups by teledermatology or feedback from primary-care physicians would be desirable, according to the dermatologists. Discussion: We found it interesting that dermatologists became increasingly confident in teledermatology after the project and how they classified teledermatology as useful for triage, diagnosis and even treatment of most types of skin conditions followed at primary care. -
MICHIGAN BIRTH DEFECTS REGISTRY Cytogenetics Laboratory Reporting Instructions 2002
MICHIGAN BIRTH DEFECTS REGISTRY Cytogenetics Laboratory Reporting Instructions 2002 Michigan Department of Community Health Community Public Health Agency and Center for Health Statistics 3423 N. Martin Luther King Jr. Blvd. P. O. Box 30691 Lansing, Michigan 48909 Michigan Department of Community Health James K. Haveman, Jr., Director B-274a (March, 2002) Authority: P.A. 236 of 1988 BIRTH DEFECTS REGISTRY MICHIGAN DEPARTMENT OF COMMUNITY HEALTH BIRTH DEFECTS REGISTRY STAFF The Michigan Birth Defects Registry staff prepared this manual to provide the information needed to submit reports. The manual contains copies of the legislation mandating the Registry, the Rules for reporting birth defects, information about reportable and non reportable birth defects, and methods of reporting. Changes in the manual will be sent to each hospital contact to assist in complete and accurate reporting. We are interested in your comments about the manual and any suggestions about information you would like to receive. The Michigan Birth Defects Registry is located in the Office of the State Registrar and Division of Health Statistics. Registry staff can be reached at the following address: Michigan Birth Defects Registry 3423 N. Martin Luther King Jr. Blvd. P.O. Box 30691 Lansing MI 48909 Telephone number (517) 335-8678 FAX (517) 335-9513 FOR ASSISTANCE WITH SPECIFIC QUESTIONS PLEASE CONTACT Glenn E. Copeland (517) 335-8677 Cytogenetics Laboratory Reporting Instructions I. INTRODUCTION This manual provides detailed instructions on the proper reporting of diagnosed birth defects by cytogenetics laboratories. A report is required from cytogenetics laboratories whenever a reportable condition is diagnosed for patients under the age of two years. -
The Tamilnadu Dr. M.G.R. Medical University Chennai, Tamil Nadu
CLINICO-PATHOLOGICAL STUDY OF SKIN SURFACE EPIDERMAL AND APPENDAGEAL TUMOURS Dissertation Submitted in partial fulfillment of university regulations for M.D. DEGREE IN DERMATOLOGY, VENEREOLOGY AND LEPROSY BRANCH XII – A THE TAMILNADU DR. M.G.R. MEDICAL UNIVERSITY CHENNAI, TAMIL NADU SEPTEMBER 2006 CERTIFICATE This is to certify that this Dissertation entitled “CLINICO-PATHOLOGICAL STUDY OF SKIN SURFACE EPIDERMAL AND APPENDAGEAL TUMOURS” is a bonafide work done by DR.G.BALAJI, Postgraduate student of Department of Dermatology, Leprosy and Institute of STD, Madras Medical College and Government General Hospital, Chennai – 3 for the award of Degree of M.D.( Dermatology, Venereology and Leprosy ) Branch XII – A during the academic year of 2003-2006. This work has not previously formed in the basis for the award of any degree or diploma. Prof. Dr. B. Parveen, MD., DD., Professor & Head, Dept. of Dermatology and Leprosy, Madras Medical College & Govt. General Hospital, Chennai – 3. Prof. Dr. Kalavathy Ponniraivan, MD., The Dean Madras Medical College & Govt. General Hospital, Chennai – 3. SPECIAL ACKNOWLEDGEMENT I sincerely thank Prof. Dr. Kalavathy Ponniraivan, MD., Dean, Madras Medical College & Govt. General Hospital, Chennai – 3, for granting me permission to use the resources of this institution for my study. ACKNOWLEDGEMENT I sincerely thank Prof. B.Parveen MD.,DD, Professor and Head of Department of Dermatology for her invaluable guidance and encouragement for the successful completion of this study. I express my heart felt gratitude to Dr.N.Gomathy MD.,DD, former Head of department of Dermatology who was instrumental in the initiation of this project, giving constant guidance throughout my work. -
Orphanet Report Series Rare Diseases Collection
Marche des Maladies Rares – Alliance Maladies Rares Orphanet Report Series Rare Diseases collection DecemberOctober 2013 2009 List of rare diseases and synonyms Listed in alphabetical order www.orpha.net 20102206 Rare diseases listed in alphabetical order ORPHA ORPHA ORPHA Disease name Disease name Disease name Number Number Number 289157 1-alpha-hydroxylase deficiency 309127 3-hydroxyacyl-CoA dehydrogenase 228384 5q14.3 microdeletion syndrome deficiency 293948 1p21.3 microdeletion syndrome 314655 5q31.3 microdeletion syndrome 939 3-hydroxyisobutyric aciduria 1606 1p36 deletion syndrome 228415 5q35 microduplication syndrome 2616 3M syndrome 250989 1q21.1 microdeletion syndrome 96125 6p subtelomeric deletion syndrome 2616 3-M syndrome 250994 1q21.1 microduplication syndrome 251046 6p22 microdeletion syndrome 293843 3MC syndrome 250999 1q41q42 microdeletion syndrome 96125 6p25 microdeletion syndrome 6 3-methylcrotonylglycinuria 250999 1q41-q42 microdeletion syndrome 99135 6-phosphogluconate dehydrogenase 67046 3-methylglutaconic aciduria type 1 deficiency 238769 1q44 microdeletion syndrome 111 3-methylglutaconic aciduria type 2 13 6-pyruvoyl-tetrahydropterin synthase 976 2,8 dihydroxyadenine urolithiasis deficiency 67047 3-methylglutaconic aciduria type 3 869 2A syndrome 75857 6q terminal deletion 67048 3-methylglutaconic aciduria type 4 79154 2-aminoadipic 2-oxoadipic aciduria 171829 6q16 deletion syndrome 66634 3-methylglutaconic aciduria type 5 19 2-hydroxyglutaric acidemia 251056 6q25 microdeletion syndrome 352328 3-methylglutaconic -
Dermatopathology
Dermatopathology Clay Cockerell • Martin C. Mihm Jr. • Brian J. Hall Cary Chisholm • Chad Jessup • Margaret Merola With contributions from: Jerad M. Gardner • Talley Whang Dermatopathology Clinicopathological Correlations Clay Cockerell Cary Chisholm Department of Dermatology Department of Pathology and Dermatopathology University of Texas Southwestern Medical Center Central Texas Pathology Laboratory Dallas , TX Waco , TX USA USA Martin C. Mihm Jr. Chad Jessup Department of Dermatology Department of Dermatology Brigham and Women’s Hospital Tufts Medical Center Boston , MA Boston , MA USA USA Brian J. Hall Margaret Merola Department of Dermatology Department of Pathology University of Texas Southwestern Medical Center Brigham and Women’s Hospital Dallas , TX Boston , MA USA USA With contributions from: Jerad M. Gardner Talley Whang Department of Pathology and Dermatology Harvard Vanguard Medical Associates University of Arkansas for Medical Sciences Boston, MA Little Rock, AR USA USA ISBN 978-1-4471-5447-1 ISBN 978-1-4471-5448-8 (eBook) DOI 10.1007/978-1-4471-5448-8 Springer London Heidelberg New York Dordrecht Library of Congress Control Number: 2013956345 © Springer-Verlag London 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. -
Proliferating Trichilemmal Cyst of the Scalp: Nine Cases and Literature Review
Otorhinolaryngology-Head and Neck Surgery Research Article ISSN: 2398-4937 Proliferating trichilemmal cyst of the scalp: Nine cases and literature review ElBenaye J1,3*, Sinaa M2,3, Elkhachine Y1,3, Sakkah A1,3, Jakar A1 and Elhaouri M1 1Department of Dermatology, Moulay Ismail Military Hospital, Meknes, Morocco 2Department of Cytopathology, Moulay Ismail Military Hospital, Meknes, Morocco 3Department of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University (USMBA), Fes, Morocco Abstract Background: proliferating trichilemmal cyst (PTC) is a rare adnexal tumor, primarily sitting on the scalp of elderly women. Its evolution is generally benign despite the rare malignant cases described. We report a series of 9 cases of which one is malignant and metastatic. Material and methods: We retrospectively reviewed data of all patients with PTC seen at department of dermatology in the Meknes military hospital, between January 2013 and December 2017. Results: Nine cases of PTC were diagnosed, which 8 in elderly women, with 62 years mean age. Trauma was found in one third of cases correlated with rapid growth of the tumor. The latter was symptomatic in 2/3 of the cases. Ulceration involved only the malignant case. The size varied from 1,5 to 12 cm. Recurrence after surgery was noted in 2 cases (malignant tumor and multi-cystic tumor). Discussion: PTC appears to have a well-distinguished profile of the simple trichilemmal cyst. Some clinical and histological features may constitute prognostic factors of aggressiveness. Histological and immunohistochemical study is crucial in the management. A large excision remains the only guarantee of complete remission without recurrence or metastasis.