MSACL 2019 EU 6th European Congress & Exhibits September 22-26 Salzburg, Austria

Clinicial Mass Spectrometry Program No doubt

The new CLAM-2030 paves the way in automation of Fully compatible with the powerful triple quad LC-MS/MS in clinical applications. This revolutionary LCMS series preparation module performs all process steps auto- providing highest sensitivity, speed and robustness matically, from pretreatment to measurement and export of data to a LIS system. The CLAM-2030 fully Meets the needs of clinical research sites ensures reliable and rapid operations with no doubt, by stable data acquisition, lower running costs and even when non-scientific staff handle the procedures. improved work efficiency

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Choice of optimal analytical methods applying commercial kits and other methods as well as screening with toxicology database

www.shimadzu.eu/no-doubt CLAM-2030 +LCM S series MSACL 2019 EU 6th European Congress & Exhibits Mass Spectrometry: Applications to the Clinical Lab Salzburg, Austria September 22-26, 2019

The Association is a non-membership, non-profit 501(c)(3) tax-exempt California Corporation with the mission of furthering education in the field of mass spectrometry.

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1 Restaurant Suggestions

There are a number of meals that you will be taking outside of the congress. This is a great opportunity to see a little more of Salzburg and explore the city's culinary delights.

Walk Name Cost Hours Description <5 m The Heart of Joy $$ 8am-7pm, 8am-8:30pm Sundays Vegetarian and vegan food. Asian Fusion, with fast take-away options my Indigo $ 1am-10pm, 12pm-9pm Sundays and cosy interior for eating in. Top pick if you need something quick. Cafe Fingerlos $$ 7:30am-7:30pm Best Breakfast in Town. Rooftop patio with a view. Bar for Drinks. IMLAUER Sky $$$ 9am-1:30am Fancy food. Cafe Wernbacher $$ 9am-1:30am Austrian, traditional interior plus a beer Braurestaurant IMLAUER $$ 11am-12am garden, good for groups.

11:30am-2pm, 5:30pm-9pm, <10 m Antichi Sapori $$ Tasty Italian food and pizza. Closed Wed,Thurs Gablerbrau $$ 11:30am-12am Historic ambiance with traditional food. Cafe Sacher $$$ 7:30am-10:30pm Nice for meal on the patio next to the river. Cozy and Traditional Austrian, lls up so Barenwirt $$ 11am - 11pm arrive early, or make reservation. Great for a nice evening meal on the patio. 12pm-2:30pm, 5pm-12am, Closed Zum delen Aen $$$ Make a reservation in advance. Small groups Sunday only.

Lovely Beer Hall and Garden, Traditional <15 m Die Wiesse $$ 10am-12am, Closed Sunday Austrian Food. Balkan Grill Walter $ 11am-7pm, 2pm-7pm Sundays A favorite take-out place. 11am-11pm. Hot food to 9pm. Traditional Austrian food since 1584, Beer Krimpelstatter $$ Closed Sun/Mon Garden, Good for groups up to 50 pax. Historic Abby turned beer garden with some food stalls, good for very large groups. The Augustiner Braustubl $ 3pm-11pm place to be Thursday evening after the close of MSACL. Taj Mahal $$ 11:30am-1:45pm, 5:30-9:30pm Good food in a lively atmosphere. Goldener Hirsch $$$ Lunch & Dinner Classic Salzburg. Fabi's Frozen Bio Yogurt $ 10am-9:30pm, 12pm-9pm Sundays Frozen Yogurt in the Old Town! Yum After Dinner, you'll nd folks from MSACL Murphy's Law Pub $ 2pm -2am here for drinks and music.

<20 m Stiftskeller St. Peter $$$ 11:30am-12am Oldest in Europe (830 AD). Take the elevator up at the Museum of M32 $$ 9am-1am, Closed Monday Modernism. M32 oers breakfast, lunch, dinner or drinks in the city over the city. Interesting ice cream avors, some non- IceZeit $ 10am-10pm dairy, good quality.

Great Beer Garden with a view over Salzburg. <25 m Steiglkeller $$ 11:30am-11pm Historic building worth a look.

There is a great outdoor cafe with drinks and a daily dish in the courtyard of the small <35 m Franziskischlössl $$ 11am-5pm, Closed Mon/Tues castle at the top of this hill. Check opening times ahead. The walk is great!

2 Distinguished Contribution Award Lecture Wednesday 16:30 in Mozart 1-5 15 years of Ambient Mass Spectrometry: From Amino Acid Clusters to Surgical Robotics Zoltan Takats Imperial College London

Plenary Lecture Plenary Lecture Tuesday 14:15 in Mozart 1-5 Thursday 17:15 in Mozart 4-5 In ammatory Stories in Time and Space: Donor-derived Cell-free DNA as a Biomarker Using Mass Spectrometry Imaging, Ion in Organ Transplantation Mobility and High Throughput Lipidomics Michael Oellerich to Understand Human Disease Institute for Clinical Pharmacology, University Jules Grin Medicine Göttingen, Germany University of Cambridge, Cambridge, UK

Keynote Lecture : Session 1 Keynote Lecture : Session 5 Metabolomics Glycomics Wed 9:00 in Track 1 (Mozart 1-3) Thu 10:30 in Track 5 (Trakl Hall) From Spectrometric Data to Metabolic The Human Glycome Project - Exploring the Networks: An Integrated Quantitative View New Frontier in Personalised Medicine of Cell Metabolism Gordan Lauc Oscar Yanes University of Zagreb; Genos Rovira i Virgili University & IISPV

Keynote Lecture : Session 2 Keynote Lecture : Session 6 Microbiology Proteomics Wed 11:00 in Track 6 (Doppler Hall) Thu 13:15 in Track 2 (Mozart 4-5) Large-Scale Inference of Protein Tissue Antibody Sequencing and Quantitation Origin in Sepsis Plasma Using Quantitative Theo Luider Targeted Proteomics Erasmus Medical Center Johan Malmström Lund University

Keynote Lecture : Session 3 Keynote Lecture : Session 7 Proteomics Regulations Wed 14:30 in Track 2 (Mozart 4-5) Thu 14:30 in Track 4 (Paracelsus Hall) The Development of Targeted Proteomic Impact of the New European IVD Regula- Assays, Attempting to Take Biomarkers from tion on Medical Laboratories - Opportuni- the Research Lab to the Clinic ties and Challenges Kevin Mills Folker Spitzenberger University of London Technische Hochschule Lübeck

Keynote Lecture : Session 3 Keynote Lecture : Session 8 Breath Analysis Tissue Imaging Wed 14:30 in Track 3 (Papageno Hall) Thu 15:45 in Track 2 (Mozart 4-5) Selected Ion Flow Drift Tube MS SIFDT-MS Imaging the Unimaginable with Imaging for Real-Time Measurement of Trace Mass Cytometry Concentrations of Volatile Compounds in Frits Koning Breath and Culture Headspace LUMC Patrik Španěl J. Heyrovský Institute of Physical Chemistry

Keynote Lecture : Session 4 Keynote Lecture : Session 8 Endocrinology Lipidomics Thu 8:30 in Track 4 (Paracelsus Hall) Thu 15:45 in Track 5 (Trakl Hall) Rethinking Sex Steroids: Understanding Skin Lipidomics in the Diagnosis and the Clinical Relevance of 11-Oxygenated Treatment of Cutaneous In ammation Androgens Anna Nicolaou Karl Storbeck Manchester University Stellenbosch University

3 Short Courses: Sun - Tue : September 22-24

Data Science 101 LC-MSMS 301 @ Trakl Hall (3rd Floor) @ Mozart 4-5 (Ground Floor) Breaking up with Excel: An Intro to the R Statistical Development and Validation of Quantitative LC-MS/MS Programming Language Assays for Use in Clinical Diagnostics Daniel Holmes, MD, William Slade, PhD, Stephen Master, Brian Rappold & Chris Shuford, PhD MD, PhD

Lipidomics 101 Data Science 201 @ Papageno Hall (Ground Floor) @ Mozart 3 (Ground Floor) Mass Spectrometry-based Lipidomics and Clinical Going Further With R: Tackling Clinical Laboratory Applications Data Manipulation and Modeling Anne Bendt, PhD, Amaury Cazenave-Gassiot, PhD & Patrick Mathias, MD, PhD, & Shannon Haymond, PhD Michael Chen, MD

Glyco-Proteomics 101 Metabolomics 202 @ Mozart 2 (Ground Floor) @ Doppler Hall (4th Floor) Unravelling The Sweetness Of Life: Clinical Metabolomics: Approaches, Applications and Glyco(Proteo)Mics By Mass Spectrometry Challenges Noortje de Haan, PhD & Guinevere Lageveen-Kammeijer, PhD Julijana Ivanisevic, PhD & Elizabeth Want, PhD

LC-MSMS 101 Proteomic Microbiology 201 @ Paracelsus Hall (2nd Floor) @ Trapp Zimmer Board Room (5th Floor) Getting Started with Quantitative LC-MS/MS in the Bottom-Up and Top-Down Proteomic Approaches for Diagnostic Laboratory Bacterial Identication and Characterization, a Focus Laura Owen, PhD, Michael Wright, Coral Munday & on MALDI-TOF and Advanced Technologies Grace van der Gugten Jean Armengaud, PhD & Stefan Zimmermann, MD

4 Scientic Committee

Elizabeth Want, PhD Gordan Lauc, PhD Imperial College London University of Zagreb; Genos SciCom Chair Glycomics

Ilaria Belluomo, PhD (Lead) Dirk Lefeber, PhD Imperial College London Radboudumc Breath & VOC Analysis Glycomics Early Career Scientist Representative

Anne Bendt, PhD (Lead) Oleg Mayboroda, PhD (Lead) Singapore Lipidomics Incubator (SLING) LUMC Lipidomics Metabolomics

Graeme Eisenhofer, PhD (Lead) Julien Boccard, PhD University of Dresden, Germany University of Geneva Endocrinology Metabolomics Early Career Scientist Representative

Flaminia Fanelli, PhD Warrick Dunn, PhD University of Bologna, Italy University of Birmingham Endocrinology Metabolomics

Tom Fiers, MD Julijana Ivanisevic, PhD University of Ghent, Belgium University of Lausanne Endocrinology Metabolomics

Brian Keevil, PhD Edward Moore, PhD (Lead) University Hospital of South University of Gothenberg, Sweden Manchester, UK Microbiology Endocrinology

Laura Owen, PhD Jean Armengaud, PhD University Hospital of South CEA-Marcoule, France Manchester, UK Microbiology Endocrinology & Practical Training

Manfred Wuhrer, Prof. dr. (Lead) Simon Cameron, PhD LUMC Queen’s University Belfast Glycomics Microbiology Early Career Scientist Representative

Guinevere Lageveen-Kammeijer, PhD Stefan Zimmerman, MD LUMC University Hospital Heidelberg, Germany Glycomics Microbiology Early Career Scientist Representative

5 Scientic Committee, continued

Grace van der Gugten (Co-Lead) Ido Kema, Prof. Dr. Provincial Health Services Authority, Canada University Medical Center Groningen, Practical Training The Netherlands Small Molecules / Tox / TDM

Laura Owen, PhD (Co-Lead) Marine Letertre, PhD University Hospital of South Manchester Imperial College London Practical Training & Endocrinology Small Molecules / Tox / TDM Early Career Scientist Representative

Roland Geyer, PhD Michael Vogeser, Prof. Dr. med. Thermo Fisher Diagnostics Institute of Laboratory Medicine, Practical Training Hospital of the University of Munich, Germany Small Molecules / Tox / TDM

Judy Stone, PhD Tiany Porta, PhD (Lead) UCSF Maastricht MultiModal Molecular Practical Training Imaging (M4I) institute Tissue Imaging

Michael Wright Isabelle Fournier, PhD LGC Université des Sciences et Technologies de Lille 1 Practical Training Tissue Imaging

Christa Cobbaert, PhD (Lead) Ron Heeren, Prof. Dr. Leiden University Medical Center Maastricht University Proteomics Tissue Imaging

Éva Hunyadi-Gulyás, PhD Ólöf Gerdur Ísberg Biological Research Centre University of Iceland / Imperial College London Proteomics Tissue Imaging Early Career Scientist Representative

Lars Melholt Rasmussen, MD, DMSc Kristina Schwamborn, MD, PhD Odense University Hospital, Institute of Pathology, TU Munich University of Southern Denmark Tissue Imaging Proteomics

Renee Ruhaak, PhD Raf Van de Plas, PhD LUMC Delft University of Technology Protemics Tissue Imaging Early Career Scientist Representative

Jody van den Ouweland, PhD (Lead) Nicola Gray, PhD Canisius-Wilhelmina Hospital, University of Reading The Netherlands Early Career Scientist Committee Chair Small Molecules / Tox / TDM

6 Tuesday

Early-Career Scientists Committee (ECSC) – Morning City Run @ Entrance Foyer 615 715 Chair: Nicola Gray Everyone is welcome to join the ECSC for a morning 5 km run in Salzburg. An ideal way to see some of the city while working off the Austrian cuisine! All abilities welcome.

Place Posters 800 1600 @ 1st Floor Exhibit Hall ALL posters should be placed by 16:00.

Welcome Coffee 800 900 @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts.

Get the Basics @ Papageno Hall Chairs: Roland Geyer & Anne Schmedes This series of Primers on emerging fields within Clinical Mass Spec is free to attend for ALL registrants of the MSACL Congress or Short Courses, including Partial Pass holders. Take aways for each session include: 1. Be able to define what the field is, why it matters, and why you personally should care. What is the clinical relevance? 2. Understand what role mass spectrometry plays in this field. Where does mass spec fit in to the big picture of the field? 900 1300 3. Define any terminology that is specific to this field. 4. Describe how it works, what are the methods and workflows used when studying this field and/or how is it implemented in clinical labs. 5. Identify any challenges to implementation/adoption, where do the opportunities lie? 09:00 - 09:40 Glycomics with Manfred Wuhrer 09:50 - 10:30 Mass Spec Imaging with Tiffany Porta 10:40 - 11:20 Lipidomics with Anne Bendt 11:30 - 12:10 Data Science with Shannon Haymond 12:20 - 13:00 Breath Analysis with Ilaria Belluomo Discussion Group: Study Design and Logistics for Metabolomics Studies 13:10 @ Papageno Hall 13:50 Chair: Jerzy Adamski Study design is a very critical step in metabolomic experiment. It has to ensure that phenotype resolution, metabolite coverage, quality-driving resources and logistic processes are considered. During the session we will interactively discuss steps like type of the study, consideration of confounders, power calculation, pre-analytical requirements, sample storage, randomization, metabolite analytics to be chosen and replication considerations.

1400 Welcome, Introduction & Orientation 1415 @ Mozart 1-5 Chair: Chris Herold Opening Plenary Lecture @ Mozart 1-5 Chair: Anne Bendt 1415 Inflammatory Stories in Time and Space: Using Mass Spectrometry Imaging, Ion Mobility and High 1500 Throughput Lipidomics to Understand Human Disease Jules Griffin Computational and Systems Medicine, Surgery and Cancer, Imperial College London, London and Department of Biochemistry, University of Cambridge, Cambridge, UK A central aspect of the development of many of the pathologies associated with the metabolic syndrome is a chronic progression of inflammation in the affected tissues. This is in part driven by lipid remodelling in the cell membrane and the production of pro-inflammatory lipid mediators produced from polyunsaturated fatty acids such as arachidonic, docosahexaenoic and eicosapentaenoic acids. To explore lipid remodelling during the development of non-alcoholic fatty liver disease we have applied MALDI-based mass spectrometry imaging (MSI) to examine both human tissue and animal models of the disease progression. Using a combination of high fat feeding and genetic modification (the ob/ob mouse which lacks leptin) to cause hepatic steatosis with and without inflammation, MSI shows that one of the events associated with disease progression is a lipid remodelling of phosphatidylcholines (PCs), and in particular, a reduction in arachidonic acid containing PCs. We have also developed a ultra-high performance liquid chromatography ion mobility mass spectrometry-based method to profile known and novel lipid mediators, using a KNIME workflow to process the data and annotate the detected lipids, in part relying on collision cross-section values for these species to aid assignments. This will be illustrated in following the time course of lipid changes in thrombin activated human platelets.

7 T U E S D A Y 1515 State of the Science Address 1615 @ Mozart 1-5

Chairs: Elizabeth Want and Roland Geyer Speakers: Ilaria Belluomo, Graeme Eisenhofer, Manfred Wuhrer, Anne Bendt, Oleg Mayboroda, Edward Moore, Lars Melholt Rasmussen, Jody van den Ouweland, Tiffany Porta, Grace van der Gugten Presented by MSACL EU Scientific Committee, this address will provide an overview of the applications and technologies currently being used in Clinical Labs, and a clear view of the development pipeline. It will highlight applications expected to be available in the near-future, as well as emerging applications, and key contributors. Exemplary talks, posters, and people present at the congress will be identified, enabling you to optimize your learning path and more effectively target potential network connections. Whether you are new to Clinical Mass Spectrometry, or a seasoned veteran, the State of the Science address should be on your agenda.

1615 Intermission 1630 @ Entrance Foyer

Poster Lightning Talks @ Mozart 1-5 Chairs: Ilaria Belluomo and Julien Boccard 1630 1700 Judges: Simon Cameron, Eva Hunyadi-Gulyas, Guinevere Lageveen-Kammeijer, Renee Ruhaak, Will Slade, Karl Storbeck, Grace van der Gugten, Elizabeth Want Poster Contest Semi-Finalists will be selected to present their pitch from the plenary podium within 90 seconds and with 1 slide (PDF format).

Exhibitor Lightning Talks @ Mozart 1-5 1700 Chair: Nicola Gray 1715 Presenting Companies: Bioinformatics Solutions, Cambridge Isotope Labs, Chromsystems, Merck, Shimadzu, Tecan, Thermo Fisher Scientific, UTAK Laboratories, Waters Learn what’s new from select vendors.

EXHIBITS OPEN 1715 @ 1st Floor Exhibit Hall

Exhibitor Reception 1715 1930 @ 1st Floor Exhibit Hall Dinner served.

Meet-a-Mentor : Booth Tours @ 1st Floor Exhibit Hall : Meet-a-Mentor Rally Point Chair: Renee Ruhaak 1800 1900 Mentors: David Herold, Laura Owen, Grace van der Gugten, Michael Wright Join an expert mentor as they tour the booths and learn more about technologies available, what experts are looking for during the exchange, and how they interact with the booth vendors. Increase your network and your knowledge of products and services available.

FeMS: Networking Reception Early-Career Scientists (ECS) - Career Options in Clinical Mass @ Mozart 1-3 Spectrometry Discussion Chairs: Anne Bendt, Grace van der Gugten, @Mozart 4-5 1930 Margrét Þorsteinsdóttir Chair: Nicola Gray 2030 This discussion group is aimed at early-career scientists and those Please join us for this inaugural FeMS event! involved with training and recruitment of the next generation. The goal is to Over wine and cheese, a few thought-provoking create awareness on career development and planning. The panel questions will be posed. Afterwards we’ll have a includes speakers from academia, industry and entrepreneurship and will discussion group at 20:30 (see below). explore transitioning between sectors. Speakers include Christiane Auray-Blais (Univ of Sherbrooke, Canada), Brian Keevil (Univ of Organized by Females in Mass Spectrometry Manchester, UK), Flaminia Flanelli (Univ of Bologna, Italy), Christian (FeMS), an initiative to bring together women in Scherling (Tecan, Germany), and Will Slade (LabCorp, USA) who will the mass spectrometry field. discuss their own professional career paths.

FeMS : Discussion Group : How to Gain Visibly in the Field of Mass Spectrometry Chair: Rita Horvath with panelists: Gwen McMillin, Margrét Þorsteinsdóttir, Julijana Ivanisevic, I-Lin Tsai & Elizabeth Want 2030 Thought-provoking questions, followed by a discussion with women at various stages in their careers, including an open period for 2130 audience questions. Exploring themes such as: (i) Best practices to achieve more visibility; (ii) How can the mass spec community participate in supporting its male and female members? (iii) How can we encourage each other to succeed? What questions do you have? Open to all! Additionally, the “Rowena Shaw Avanti Award for Women in Mass Spectrometry”, a $2000 USD discretionary award funded by Avanti Polar Lipids, will be introduced. 8 Wednesday

800 845 Corporate Workshop(s) Merck Thermo Fisher Scientific SCIEX @ Mozart 4-5 (Track 2) @ Papageno (Track 3) @ Paracelsus (Track 4) Enhancing Accuracy: Matrix Selection, Internal 1. Achieve Superior Confidence in Your LC-MS Advanced mass spectrometry techniques Standard Selection, and Sample Clean-Up Analysis, Claudio DeNardi, Thermo Fisher provide deeper access into the vitamin D Solutions for Clinical Mass Spectrometry metabolome Geoffrey Rule,PhD, Merck 2. Trying to stay one-step ahead – how Pascal Schorr, Humboldt-University, High-Resolution Accurate Mass LCMS has Berlin enabled early detection of fentanyl analogues (including carfentanil) and synthetic cannabi- noids in the UK, Simon Hudson, LGC, UK Scientific Session 1 Track 1 Track 2 Track 3 Track 4 Track 5 Track 6 Mozart 1-3 Mozart 4-5 Papageno Hall Paracelsus Hall Trakl Hall Doppler Hall

Metabolomics Proteomics: Quality Control Small Molecules: Lipidomics: Breath Analysis Keynote Reinventing Old Chair: Rita Horvath Metabolomics in Applications for and VOC in Cancer Chair: Oleg Biomarkers Toxicology Doping, Nutrition Chair: Kseniya Mayboroda Chair: TBA Chair: Jody van den and Lab Med Dryahina Ouweland Chair: Erika Dorado 2nd Chair: H. Koguna 2nd Chair: Juliane 2nd Chair: Panagiotis Fagotti Vorkas 900 From HILIC-LC-MRM- A Proposal to UPLC-MS/MS- Development and Investigating the 920 Spectrometric Data MS Enables the Standardize the based Assays for Validation of a Gas- Relationship to Metabolic Quantitation of PSA Description of LC- Diagnosis and Chromatography between TRIM44 Networks: An and its Major MS -based Therapeutic Mass Spectrometry and P53 Metabolic Integrated Glycoforms to Measurement Monitoring in Method for the Pathways in Human Quantitative View of Improve Prostate Methods in Patients with APRT Analysis of Colon Cancer Cells Cell Metabolism Cancer Diagnostics Laboratory Medicine Deficiency Testosterone Esters in a 3D Model, Using Oscar Yanes L.Renee Ruhaak Michael Vogeser Unnur Arna in Biological PTR-ToF-MS CIBER & URV & Leiden University Hospital of the Thorsteinsdottir Matrices Katerina-Vanessa IISPV Medical Center University of Munich University of Iceland Michele Iannone Savva (LMU) Young Investigator Grant Laboratorio PhD, Imperial Antidoping FMSI, College London Rome, Italy Young Investigator Grant Young Investigator Grant 920 Proteomic Metrological Investigation of Determination of VOC-based Real- 940 Analysis of Prostate Traceability of Lp(a) Bacterial β- Serum Triglyceride Time Breast Cancer ... Cancer Biopsies Requires Defining Glucuronidase by Isotope Dilution Diagnostic Using Keynote Gábor Tóth the Measurand and Inhibition on the LC-MS/MS LTP-MS ... MS Proteomics Introducing Molar Metabolic Profile of Weiyan Zhou Flore Herve Research Group, Units Mice Using a NCCL Beijing PhD student, PRISM RCNS-HAS Christa Cobbaert Combined Platform Hospital U1192 Young Investigator Grant Leiden University of NMR and LCMS- Young Investigator Grant Medical Center based Untargeted Metabolomics Marine Letertre Imperial College London Young Investigator Grant 940 ... The Analysis of Rigorous Quality Development of a Whole Blood Volatile Organic 1000 Keynote Alpha-1-Antitrypsin Management Liquid Omega-3 Index by Compound (VOC) ... Glycosylation in Enables Long-Term Chromatography Gas Profiling in Liver HCC Patient Serum Robustness of MS- Quadrupole Time-of- Chromatography Disease via Haidi Yin based Protein Flight Mass Dependence on Age Selected-Ion Flow- The Hong Kong Quantitation Spectrometry (LC- and Gender in Tube Mass Polytechnic Nico Smit QTof MS) Method for Caucasian Spectrometry (SIFT- University Leiden University the Screening of Population MS) Medical Center Antihypertensive Vasiliy Yurasov Michael Hewitt Drugs in Urine Scientific laboratory Imperial College Alexander Lawson "Chromolab" London = Emerging. More than 5 years before clinical availability. (35.32%) University Hospitals Young Investigator Grant = Expected to be clinically available in 1 to 4 years. (32.77%) Birmingham NHS FT = Clinically available now. (31.91%)

9 W E D N E S D A Y

Poster Session 1 1000 1100 @ 1st Floor Exhibit Hall Selected posters to be attended for 1 hour.

Scientific Session 2

Mozart 1-3 Mozart 4-5 Papageno Hall Paracelsus Hall Trakl Hall Doppler Hall

Metabolomics: Proteomics: Practical Training: Endocrinology: Clinical Glycomics I Microbiology Clinical Apps I Metrological Traceable Clinical Serum Steroids Chair: Guinevere Keynote Chair: Oleg Traceability and Measurement Chair: Karl Storbeck Lageveen- Mayboroda Absolute Chair: Roland Geyer 2nd Chair: Elizabeth Kammeijer Chair: Roger 2nd Chair: Chung-Ho Quantification Baranowski 2nd Chair: Gábor Tóth Karlsson Lau Chair: Christa 2nd Chair: Petra Paizs Cobbaert 1100 Metabolomics Development of an Traceable Clinical The Harmoster Comprehensive Large-Scale 1120 Analysis of Blood Immunoprecipitation Measurement Initiative: Preliminary Glycopeptide Inference of Protein Plasma for Early Method for the Chris Hopley Results on the Profiling in Blood Tissue Origin in Diagnosis of Uterus Analysis of Intact NML Comparability of Plasma for Clinical Sepsis Plasma Leiomyoma Parathyroid Circulating Steroid Applications Using Quantitative Recurrences Hormone (PTH) and Measurement Melissa Targeted Proteomics Vladimir Frankevich Related Forms by Among Ten Baerenfaenger Johan Malmström Research Center for LC-MS/MS European Radboudumc Department of Obstetrics and Jordi Farré-Segura Laboratories Using Clinical Sciences Gynecology University of Liège LC-MS/MS Young Investigator Grant Flaminia Fanelli University of Bologna 1120 Metabolomics Multiplexing Multidimensional Ultrahigh 1140 Applied to Coronary Kidney Injury and Diagnostics with Resolution MS Clinical Burden: Use Kidney Specific Machine Learning for Profiling of Plasma of Mass Biomarkers in Urine Primary N-Glycans in Large Spectrometry to Re- Using MS-based Aldosteronism Type 2 Diabetes Stratify Bottom-Up Graeme Eisenhofer Cohorts ...... Asymptomatic Proteomics: A Technische Elham Memarian Extended Session Keynote Subjects of Robust and Feasible Universität Dresden Leiden University ...... Intermediate Approach Medical Center Cardiovascular Risk Tirsa van Duijl Young Investigator Grant Aline Martins Leiden University Universidad CEU Medical Center San Pablo Madrid (LUMC) Young Investigator Grant 1140 Metabotyping Burn The Combined An Ultrasensitive IgG and IgA 1200 Injury Using UPLC- Use of Lys-C and High-Throughput Glycopeptide MS Coupled with Trypsin Provides LCMS/MS-Method Characterization by Microdialysis Better Digestion for Estradiol and LC-MS Reveals Elizabeth Want Efficiency for MS- ... Estrone in the Sub- Associations with ... Imperial College based Protein Extended Session Picomolar Range Inflammatory Bowel Keynote London Quantitation ... Bjørn-Erik Bertelsen Disease Subtypes ... Fred Romijn Hormone Laboratory, and Behavior Leiden University Haukeland Noortje de Haan Medical Center University Hospital LUMC

1200 Lunch 1330 @ 1st Floor Exhibit Hall

1230 Troubleshooting Poster Rounds : Part II 1315 @ 1st Floor Exhibit Hall with Chair, Grace van der Gugten

12:30 at poster #24a 12:45 at poster #24b 13:00 at poster #24c The Hurdles of Developing an LC-MS/MS Fast and Efficient Method for Detection Matrix Dilemmas in LC-MS/MS: The Use Assay for Desmosine, a Biomarker for and Quantification of Catecholamines in of Appropriate Calibrators and Internal Elastin Degradation Human Plasma by LC-MS/MS - Standards to Facilitate Acceptable Criteria Jody van den Ouweland Troubleshooting for Quantification Canisius-Wilhelmina Hospital Chiara Calaprice Tania Grobler University Hospital of Liege North-West University

10 W E D N E S D A Y

1330 1415 Corporate Workshop(s) Shimadzu Thermo Fisher Scientific Waters Agilent Technologies @ Mozart 4-5 (Track 2) @ Papageno (Track 3) @ Paracelsus (Track 4) @ Trakl (Track 5) 1. MALDI-MS technology combined with Laboratory-Developed Mass Spectrome- Mass Spectrometry advantages for Fast Track your Cannabinoid Urine automated interpretation software, a try Testing vs Regulatory-Approved Therapeutic Drug Monitoring: a closer Analysis using MassHunter StreamSe- solution adapted to high throughput Tests: Pros and Cons look at teicoplanin lect LC-MS System screening: Sickle cell disease screening Part 1: Balancing the pros and cons of Brian Keevil, Professor at University Moritz Wagner, Product Specialist, in newborns as a first application Mass Spec-based Lab-Developed-Tests Hospital Southern Manchester, UK Agilent Technologies 2. Robustness and reliability of the as compared to Regulatory-Approved novel pre-analytical filtration system Tests under the new IVD Regulation CLAM-2030 and LCMS-8050 2017/746 in Europe 3. Rethinking the capability and Part 2: Cascadion™ SM 25-Hydroxy workflows in clinical metabolomics and Vitamin D and Immunosuppressants biomarker research using the Panel—Assays on the Cascadion™ SM LCMS-9030 Q-TOF technologies Clinical Analyzer , Scientific Session 3

Mozart 1-3 Mozart 4-5 Papageno Hall Paracelsus Hall Trakl Hall Doppler Hall

Metabolomics: Proteomics Breath Analysis Small Molecules: Lipidomics in MALDI for the Clinical Apps II Keynote Keynote: Patrik From Vitamins, Cancer Clinical Laboratory Chair: Nicola Gray Chair: Christa Španěl Drugs to Chemical Chair: Vladimir Chair: David Herold Cobbaert Chair: Ilaria Warfare Frankevich Belluomo Chair: Michael 2nd Chair: Kenji Vogeser Nakayama 1430 Assessing the The Development Selected Ion Flow Development of an MALDI-TOF/MS Optimization of 1450 Metabolome of of Targeted Drift Tube Mass LC-MS/MS Assay for Analyses of Urinary MALDI-based Preterm Newborns: Proteomic Assays, Spectrometry SIFDT- Biotin Quantitation to Phospholipids and Techniques for the Findings from a Attempting to Take MS for Real-Time Support Research Lysophospholipids Rapid Diagnostics of Danish Population- Biomarkers from the Measurement of on Biotin as Potential Sepsis based Study Research Lab to the Trace Interference of Diagnostic Miriam Cordovana Madeleine Ernst Clinic Concentrations of Immunoassays Biomarkers for A.O.U. Policlinico Statens Serum Kevin Mills Volatile Compounds Antoinette IJpelaar Prostate Cancer Sant'Orsola-Malpighi Institut University College in Breath and CWZ Hospital Xin Li London Culture Headspace Young Investigator Grant Kyoto University Patrik Španěl Young Investigator Grant J. Heyrovský Institute of Physical Chemistry 1450 Podocyturia LC-MS/MS for Can Rapid MALDI Chip 1510 Evaluation in Women Peptide-Adduct Evaporative Technology for in with Preeclampsia Analysis to Verify Ionization Mass situ Detection of and Fabry Disease Poisoning with Spectrometry Human Procalcitonin Patients Using a Chemical Warfare (REIMS), the Petr Pompach Tandem Mass Agents and Intelligent Surgical Institute of ...... Spectrometry Pesticides Knife (iKnife) Microbiology Keynote Keynote Approach Harald John Provide a Point-of- ...... Christiane Auray- Bundeswehr Institute Care Diagnosis for Blais of Pharmacology & Endometrial Cancer Université de Toxicology Diana Marcus Sherbrooke Imperial College London Young Investigator Grant 1510 Exploratory Analysis of Lipidomic Study of Potential of TiO2 1530 Metabolomics of Fentanyl and Cell Lines Reveals Nanoparticles for Urine and Plasma to Metabolite in Clinical Differences between Mass Spectrometric Identify Novel and Post-Mortem Breast Cancer Detection and Pharmacodynamic Samples Subtypes Quantification of ...... Biomarkers in a Karen Scott Finnur Freyr Biologically-Relevant Keynote Keynote Phase I Clinical Trial Arcadia University Eiriksson Small Molecules ...... of AZD3965 University of Iceland Marijana Petkovic Alexandros Siskos University of Imperial College Madeira, CQM- London Centre for Chemistry Young Investigator Grant

11 W E D N E S D A Y

1530 Poster Session 2 1630 @ 1st Floor Exhibit Hall

Meet-a-Mentor : Poster Tours 1530 @ 1st Floor Exhibit Hall : Meet-a-Mentor Rally Point 1630 Chair: Renee Ruhaak Mentors: Isabelle Fournier, David Herold, Anna Nicolaou, Brian Rappold

Distinguished Contribution Award Lecture @ Mozart 1-5 Chair: Elizabeth Want 1630 15 years of Ambient Mass Spectrometry: From Amino Acid Clusters to Surgical Robotics 1730 Zoltan Takats Imperial College London

Professor Takats obtained his PhD from Eötvös Loránd University, Budapest, Hungary. He worked as a post-doctoral research associate at Purdue University, Indiana, USA. After returning to Hungary, he served as Director of the Cell Screen Research Centre and also as Head of Newborn Screening and Metabolic Diagnostic Laboratory at Semmelweis University, Budapest.

Professor Takats was awarded a Starting Grant by the European Research Council in 2008 and he subsequently became a Junior Research Group Leader at Justus Liebig University, Gießen, Germany. He moved to the United Kingdom in 2012 and is currently a Professor of Analytical Chemistry and Director of Mass Spectrometry Research within Division of Computational Systems and Medicine at Imperial College London.

Professor Takats has pursued pioneering research in mass spectrometry and he is one of the founders of the field of ‘Ambient Mass Spectrometry’. He is the primary inventor of six mass spectrometric ionisation techniques, including Desorption Electrospray Ionization and Rapid Evaporative Ionization Mass Spectrometry.

He was the recipient of the prestigious Mattauch-Herzog Award of the German Mass Spectrometry Society and the Hungarian Star Award for Outstanding Innovators. He is the founder of Prosolia Inc, Medimass Ltd and Massprom Ltd, all companies pursuing analytical and medical device development. Professor Takats has published over 100 peer-reviewed articles in the fields of analytical chemistry and translational medicine.

Exhibitor Reception 1730 1900 @ 1st Floor Exhibit Hall Wine and Light Appetizers served in Exhibit Hall.

Meet-a-Mentor : Office Hours Forum @ 1st Floor Cafe : Meet-a-Mentor Rally Point 1800 Chair: Renee Ruhaak 1900 Mentors: Christiane Auray-Blais, Anne Bendt, Shannon Haymond, David Herold, Daniel Holmes, Patrick Mathias, Anna Nicolaou, Brian Rappold, Chris Shuford, Will Slade, Grace van der Gugten, Elizabeth Want Have a question from the congress that you have been itching to ask? Or a problem from work that you want to get feedback on? Need career advice? Sign up at the registration desk for 15-min blocks to share time and ideas with domain experts. Enjoy the City 1900 @ Your Choice Plan to join a few colleagues for dinner in Salzburg tonight. Some places to try: 1. Braurestaurant IMLAUER (Austrian, traditional interior plus a beer garden, good for groups, close to congress) 2. Krimpelstatter (Traditional Austrian food since 1584, Beer Garden, serving hot food to 9pm, open to 11pm) 3. Steiglkeller (Historic building with a great view over the Old Town, near the Fortress) 4. Gablerbrau (Historic ambiance with traditional food) 5. Cafe Wernbacher (Austrian, great for a rainy day with original 1950s decor, open 9am-midnight daily, near congress) 6. Die Weisse 7. Indian Restaurant Taj Mahal

For a special meal (reservation advised): 1. Restaurant Goldener Hirsch 2. Stiftskeller St. Peter 3. Zum fidelen Affen 4. M32

After dinner: 1. Murphys Law Irish Pub (Common place to meet MSACL folks for drinks and music).

12 Thursday

Welcome Coffee 800 830 @ Entrance Foyer Enjoy coffee, a pastry and a chat with colleagues before the day starts.

Scientific Session 4 Track 1 Track 2 Track 3 Track 4 Track 5 Track 6 Mozart 1-3 Mozart 4-5 Papageno Hall Paracelsus Hall Trakl Hall Doppler Hall

Metabolomics: Proteomics: High Practical Training Endocrinology Clinical Glycomics Data Science Clinical Throughput Chair: Michael Keynote II Chair: Stephen Applications III Methodology Wright Chair: Brian Keevil Chair: Valeriia Kuzyk Master Chair: Christiane Chair: Éva Hunyadi- Auray-Blais Gulyás 2nd Chair: Vitaliy Chagovets

830 The Use of Rapid Maximize the Multi-Analyte Rethinking Sex Successful Faecal A Chromatogram 850 Evaporative Output of Routine Methods: A Free Steroids: Microbiota Says a Thousand Ionisation Mass Proteome Analyses Lunch or a Understanding the Transplantation for Numbers: Data, Spectrometry by Using Micro Pillar Frightening Bill? Clinical Relevance of Recurrent Decisions, and (REIMS) as a Real- Array Column Coral Munday 11-Oxygenated Clostridioides difficile Directions Time Bedside Test in Technology LGC Ltd Androgens Infection Associates William Slade Cervical Cancer Christof Mitterer Karl Storbeck with Decreased Laboratory Screening PharmaFluidics NV Stellenbosch Complexity of the Corporation of Maria Paraskevaidi University Serum N-Glycome America Holdings Imperial College Maja Pučić Baković London Genos Glycoscience Young Investigator Grant Research Laboratory 850 Clinically Relevant DirectMS1: A Novel Chemometric 910 Metabolites of the High-Throughput Glycopeptide Strategies for Human Gut Analysis for Analysis Strategy for Sensitive Regions of Microbiota Identification and Prostate-Specific Interest Annotation Zdenek Spacil Quantification of ...... Antigen in Seminal in Complex Imaging Masaryk University 1000 Proteins in 5 Extended Session Keynote Plasma of Infertile Mass Spectrometry Minutes ...... Men Data Mark Ivanov Wei Wang Patrick Wehrli INEPCP FRCCP Leiden University University of RAS Medical Center Gothenburg Young Investigator Grant Young Investigator Grant 910 Exploring the Comparison of Colorectal Cancer 930 Interactions between MRM- and DIA- Cell Lines Reveal Dietary Polyphenols, based Protein Striking Isomeric the Gut Microbiome Quantification Using Diversity of Human and Human Health a 500 Protein Blood Cancer O-Glycome ...... Nicola Gray Panel in Plasma Katarina Madunic Extended Session Keynote TBA University of Samples LUMC ...... Reading, UK Demonstrates Young Investigator Grant Young Investigator Grant Linearity between Methods Claudia Escher Biognosys AG

Poster Session 3 930 1030 @ 1st Floor Exhibit Hall Selected posters to be attended for 1 hour. Refer to program for posters attended during this period.

Poster Contest Finalist Interviews 930 @ 1st Floor Exhibit Hall 1030 Chairs: Ilaria Belluomo and Julien Boccard . Judges: Simon Cameron, Eva Hunyadi-Gulyas, Guinevere Lageveen-Kammeijer, Renee Ruhaak, Will Slade, Karl Storbeck, Grace van der Gugten, Elizabeth Want

Poster Contest Finalists to attend posters and meet with poster Judges. Judges may arrive in groups or individually.

13 T H U R S D A Y

1030 Exhibitor Feedback Discussion 1130 @ 1st Floor Cafe All exhibitors are welcome to attend this discussion with the organizers and provide feedback.

Scientific Session 5

Mozart 1-3 Mozart 4-5 Papageno Hall Paracelsus Hall Trakl Hall Doppler Hall

Metabolomics: Proteomics: Pre- Practical Training: Small Molecules: Glycomics Microbiology: Data Analysis analytical Assessing the From Basic to Keynote Tandem MS-MS Workflows Considerations for Quality and Novel Approaches Chair: Manfred Proteomics and Chair: Julien Patient and Robustness of LC- in TDM Wuhrer Clinical Boccard Specimen MS/MS assays Chair: Marine Diagnostics 2nd Chair: Víctor Preparation Chair: Laura Owen Letertre Chair: Jean González Ruiz Chair: Lars Armengaud Rasmussen 2nd Chair: Miriam Cordovana

1030 Plasma Precise Assessing the Application of a The Human Discovery of 1050 Metabolomics Quantitative Serum Quality and Molecular Glycome Project - Species-Unique Profiles Associated LC-MS/MS Profiling: Robustness of LC- Networking Exploring the New Peptides as with Endothelial The Impact of MS/MS Assays Approach for Frontier in Candidate Peptide Health and Sample Preparation James Hawley Therapeutic Drug Personalised Biomarkers for Dysfunction and their and Sample Source Manchester Monitoring (TDM) Medicine Respiratory Tract Influence on on Biomarker University NHS and Toxicology Gordan Lauc Pathogens Using Endothelial Discovery Studies Foundation Trust Emmanuel University of Zagreb Tandem Mass Metabolism Oleksandr Bourgogne Spectrometry-based Óttar Rolfsson Boychenko Université de Paris, Proteotyping University of Iceland Thermo Fisher Faculté de Roger Karlsson Scientific Pharmacie, Sahlgrenska UMR8038 University Hospital 1050 KIMBLE: A Proteomic Potential of MALDI Quick Pathogen 1110 Versatile Visual NMR Discovery and MS for Detection of Identification and Metabolomics Validation of the [Ru(η5-C5H5) Antibiogram for the Workbench in Confounding Effect (PPh3)2Cl] Clinics by MS/MS KNIME of Heparin Metabolites in Proteotyping Aswin Verhoeven Administration on the ... Patient Body Fluids ... Jean Armengaud Leiden University Analysis of Extended Session – a Preliminary Keynote CEA Medical Center Candidate ... Study ... Cardiovascular Nádia Nunes Biomarkers CQM, University of Hans Christian Beck Madeira Odense Young Investigator Grant universitetshospital 1110 Computational The Predictive Therapeutic Drug Robust Accurate 1130 Analysis of Mass Potential of Salivary Monitoring of Identification and Spectrometry Data Proteomics for Clofazimine in Indian Biomass Estimates for Standardised Characterization of MDR-TB Patients of Microorganisms Diagnosis of Inborn the Phases of Prerna Chawla via Tandem Mass Disorders of Allogeneic P.D. HINDUJA Spectrometry ...... Steroidogenesis Hematopoietic Stem HOSPITAL & MRC Yu Yi-Kuo Extended Session Keynote Elizabeth Cell Transplants Young Investigator Grant National Center for ...... Baranowski Milena Souza Biotechnology IMSR, University of International Information Birmingham Research Center, Young Investigator Grant A.C.Camargo Cancer Young Investigator Grant

1130 Lunch 1315 @ 1st Floor Exhibit Hall

14 T H U R S D A Y

1200 Poster Session 4 1300 @ 1st Floor Exhibit Hall

Meet-a-Mentor : Poster Tours 1200 1300 @ 1st Floor Exhibit Hall : Meet-a-Mentor Rally Point Chair: Renee Ruhaak Mentors: Isabelle Fournier, David Herold, Brian Rappold

1300 Remove Posters @ 1st Floor Exhibit Hall

EXHIBITS CLOSED 1315 @ 1st Floor Exhibit Hall

Scientific Session 6

Mozart 1-3 Mozart 4-5 Papageno Hall Paracelsus Hall Trakl Hall Doppler Hall

Metabolomics of Proteomics Practical Training: Endocrinology: MS Imaging: Breath Analysis Model Systems Keynote Calibration and Miscellaneous Method and VOC: New Chair: Petra Paizs Chair: Christa Metrology for Chair: Flaminia Development Technology Cobbaert Protein MS tests Fanelli Chair: Isabelle Chair: Patrik Spanel Chair: Grace Fournier van der Gugten 1315 LC- and CE-MS- Antibody Calibration and Validation of a Imaging Spatial Real-Time 1335 based Workflow for Sequencing and Metrology for Protein Rapid LC-MS/MS Abeta Plaque Therapeutic Metabolic Read- Quantitation MS Tests Method with Simple Aggregation Monitoring of Across of New Theo Marten Luider L.Renee Ruhaak Solid Phase Dynamics in Valproic Acid in Toxicants in Erasmus MC Leiden University Extraction for Evolving AD Exhaled Breath Neuroinflammation Medical Center Analysis of Pathology Using Kapil Dev Singh Víctor González- Catecholamines and iSILK University of Basel Ruiz their Metabolites in Wojciech Michno University of Geneva Plasma Sahlgrenka Young Investigator Grant Songlin Yu Academy at the Peking Union University of Medical College Gothenburg Hospital Young Investigator Grant 1335 Metabolomic A Novel LC- High-Throughput Determination of 1355 Analysis of Human MS/MS Method for Automated Tissue Aldehydes, Ketones, Atherosclerotic the Quantification of Imaging by DESI- Short Chain Fatty Plaques Reveals a Five Androgens in MS, Three- Acids and Alkanes in Pathway of Foam Cell Saliva Dimensional Tissue Breath and Biofluids ...... Apoptosis in Malcolm McTaggart Imaging or Large with GcxGC-TOF- Keynote Extended Session Advanced Manchester Sample Cohort MS-FID ...... Atherosclerosis University NHS Mapping Antonis Myridakis Panagiotis Vorkas Foundation Trust Emrys Jones Imperial College Imperial College Waters Corporation London London Young Investigator Grant Young Investigator Grant 1355 Nontargeted C-20 Strategy for the Deep Urinary 1415 Metabolite Profiling Hydrogenation is Prediction of Volatile Organic of Human Lung Involved in Neoadjuvant Compound Profiling Epithelial Cells Intrauterine Cortisol Therapy Response with Headspace (A549) with HILIC Homeostasis in Breast Cancer by Sorptive Extraction Mode UPLC HRMS: Offering an MALDI-MSI and GCxGC-MS for Silica Nanoparticle Additional Sex- Tiffany Porta Oesophago-Gastric ...... Mediated Driven Protection to M4I institute, Cancer Detection Keynote Extended Session Cytotoxicity Effects Prenatal Stress. Maastricht University Qing Wen ...... Kalyan Paila Implications in Imperial College Pemiscot Memorial Birthweight London Hospital Alex Gomez Young Investigator Grant Fundació Institut Mar d'Investigacions Mèdiques Young Investigator Grant

15 T H U R S D A Y

Scientific Session 7

Mozart 1-3 Mozart 4-5 Papageno Hall Paracelsus Hall Trakl Hall Doppler Hall

Exploratory Proteomics: Practical Training: Small Molecule MS Imaging: Microbiology: Metabolomics Emerging Clinical Biomarker Keynote Clinical Novel MS Clinical Chair: Zdenek Spacil Applications Discovery and Chair: Ido Kema Diagnostics Applications Chair: Renee Translational Chair: Tiffany Porta Chair: Simon Ruhaak Research Cameron 2nd Chair: Tirsa van Chair: Grace van 2nd Chair: Belen Duijl der Gugten Rodriguez-Sanchez

1430 Untargeted The End of Kozak Biomarker Impact of the New High-Throughput MBT FAST – 1450 Steroidomics for the Dogma: The Ghost Discovery and European IVD Analysis on FFPE Rapid Antimicrobial Identification of Proteome Translational Regulation on Breast Cancer TMAs Susceptibility Testing Novel Steroid Michel Salzet Research Leading to Medical Laboratories with DESI-MSI by MALDI-TOF MS Profiles in Université Lille Clinical Utility: - Opportunities and Olof Gerdur Isberg Markus Kostrzewa Dysregulated Experimental Challenges University of Iceland Bruker Daltonik Steroidogenesis Approaches and Folker Spitzenberger Young Investigator Grant GmbH Paal William Wallace Pitfalls University of Applied Technische Christiane Auray- Sciences Luebeck Universität Dresden Blais & Michel Boutin Young Investigator Grant Université de Sherbrooke 1450 Untargeted Shortgun Laser Desorption Detection of 1510 Metabolomic Profiles Proteomics for Imaging – Rapid Vancomycin- of Newborns that Differential Diagnosis Evaporative Resistant Will or Will Not of HPV-associated Ionisation Mass Enterococcus Develop Autism: A Cervix Spectrometry faecium Using ...... Pilot Study on Dried Transformation Platform for Tissue MALDI-TOF Mass Extended Session Keynote Blood Spots Natalia Imaging Spectrometry ...... Julie Courraud Starodubtseva Daniel Simon Belén Rodríguez- Statens Serum National Medical Imperial College Sanchez Institut Research Center of London Hospital General Obstetrics Young Investigator Grant Universitario Gregorio Marañón 1510 Exploring the Multiplex Assay for Towards In vivo Development of 1530 Volatomic Absolute Molecular Laser Assisted Fingerprinting of Quantification of Diagnostics of Rapid Evaporative Breast Cancer Inflammatory Esogastric Cancer Ionization Mass Tissue as an Proteins in 134 with Spidermass Spectrometry (LA- ...... Untargeted Meconium and First Real-Time, Mini REIMS) as a Extended Session Keynote Approach to Identify Stool Swabs from Invasive Analysis Platform for Clinical ...... Potential Biomarkers CELSPAC-TNG Birth Nina Ogrinc Microbiology: The Rosa Perestrelo Cohort Study University of Lille, Past and the Future Centro de Química Eliška Stuchlíková PRISM laboratory Simon Cameron da Madeira, UMa Masaryk University Young Investigator Grant Queen's University Young Investigator Grant Young Investigator Grant Belfast

1530 Intermission 1545 @ Entrance Foyer

MSACL-KSCC Satellite Meeting Clinical Mass Spectrometry May 24, 2020 Coex, Seoul, Korea

16 T H U R S D A Y

Scientific Session 8

Mozart 1-3 Mozart 4-5 Papageno Hall Paracelsus Hall Trakl Hall Doppler Hall

Metabolomics: MS Imaging Practical Training Late-Breaking Lipidomics Tackling Keynote Chair: Grace van Science Keynote Chair: Anne Bendt Challenging Chair: Tiffany der Gugten Chair: Jody van Samples Porta den Ouweland Chair: Elizabeth Want 1545 Determination of Imaging the Design of In-Matrix Skin Lipidomics in 1605 D- and L-Lactic Acid Unimaginable with Experiments (DoE) – Derivitization of the Diagnosis and in Urine by UPLC- Imaging Mass Get it Right from the Indole Treatment of MS with Electrospray Cytometry Beginning Measurements Cutaneous Ionization Frits Koning Margrét by LC-MSMS Inflammation Quantification LUMC Thorsteinsdottir Martin Faassen Anna Nicolaou Juliane Fagotti University of Iceland University Medical The University of Imperial College Manchester Center, Groningen, London Young Investigator Grant the Netherlands 1605 Optimising Laser 1625 Assisted - Rapid Evaporative Track Ionization - Mass Spectrometry Closed Imaging (LA-REI- ...... MSI) for the Spatially Keynote Extended Session TBA Keynote Resolved Analysis of ...... Faecal Metabolites Petra Paizs Imperial College London Young Investigator Grant 1625 Steroidomics 1645 Profile Analysis by LCHR-MS in Human ...... Seminal Fluid Keynote Extended Session TBA Keynote Eulalia Olesti ...... University of Geneve Young Investigator Grant

17 T H U R S D A Y

Plenary Reception 1645 1700 @ Entrance Foyer Ground Floor Bar to serve wine and other beverages for intermission while preparing for the poster awards.

1700 Poster Award Presentation 1715 @ Mozart 4-5 Chairs: Ilaria Belluomo and Julien Boccard Closing Plenary Lecture @ Mozart 4-5 Chair : Stephen Master 1715 Donor-derived Cell-free DNA as a Biomarker in Organ Transplantation 1800 Michael Oellerich Institute for Clinical Pharmacology, University Medicine Göttingen, Germany

Molecular biomarkers have attracted special attention in solid organ transplantation because of unresolved problems that limit long-term outcome. There is a lack of reliable noninvasive markers. Immunosuppressive drug monitoring mainly indicates potential toxicity, but is a poor biomarker of graft damage. In kidney transplant patients, for example, an increase of plasma creatinine may be also be due to exsiccation, the use of ACE inhibitors, or immunosuppressive drug toxicity. By the time a rejection-related increase in plasma creatinine is evident, a significant degree of tissue damage has already occurred within the kidney. A further limitation of the current standard of care is that rejection episodes can only be confirmed by biopsies. Biomarkers are needed to achieve personalized immunosuppression to reduce premature graft loss. Against this background, a particularly promising new approach for the early detection of acute or chronic rejection or asymptomatic graft injury leading to irreversible damage is based on the determination of donor-derived circulating cell-free DNA (dd-cfDNA). Data on clinical validity have been documented in more than 48 independent studies which have shown that dd- cfDNA detects rejection episodes early, at an actionable stage, and is a more reliable marker of graft injury, compared to conventional tests. dd-cfDNA may also be useful to guide changes in immunosuppression, to monitor immunosuppression minimization (e.g. during tapering), and to prevent immune activation. The high negative predictive value of dd-cfDNA is the reason why this test can be helpful to avoid unnecessary biopsies. It could be shown that dd-cfDNA can be useful to detect subclinical (e.g. clinically unsuspected) graft damage as a result of immune activation triggered by under-immunosuppression. Early diagnosis of subclinical antibody- mediated rejection may improve outcomes after kidney transplantation. In summary, dd-cfDNA monitoring will allow more personalized treatment that shifts emphasis from reaction to prevention.

1800 Final Remarks 1815 @ Mozart 4-5 Chair: Elizabeth Want

Closing Petite Reception 1815 1900 @ Entrance Foyer . Wine & Cheese, Beer, light snacks. Winning posters to be on display

CONGRESS CLOSED 1900 @ Entrance Foyer

After Congress Meet-Up 1900 @ Your Choice 2200 Meet up at the Augustiner Braustubl (Historic Abby turned beer garden with food stalls) for an unofficial and unsponsored post- con gathering.

18 Posters to be Presented

= Emerging. More than 5 years before clinical availability. (35.32%) All posters (n=153) are to be placed by Tuesday at 16:30 and = Expected to be clinically available in 1 to 4 years. (32.77%) will remain placed for the duration of the congress. Poster = Clinically available now. (31.91%) removal is from 1300-1315 on Thursday.

Breath and VOC Analysis Data Science

Poster #3c : Thursday : 09:30, attended for 1 hour Poster #8a : Wednesday : 10:00, attended for 1 hour SHS-GC-MS Optimization for Volatile Organic Compounds Modelling the Within- and Between-run Variation in Internal Analysis in Oral Fluid and Urine Standard Signal to More Accurately Assess Ion Suppression Bruno Costa, University of São Paulo Effects Edmund Wilkes, Imperial College Healthcare NHS Trust Poster #4a : Wednesday : 10:00, attended for 1 hour Young Investigator Grantee Impact of Oral Cleansing Strategies on Exhaled Volatile Organic Compound Levels Poster #19a : Wednesday : 10:00, attended for 1 hour Bhamini Vadhwana, Imperial College London Bioassay Classification Study via LC-MS and Machine Young Investigator Grantee Learning in Conjunction with Dimensionality Reduction Ivan Plyushchenko, Lomonosov Moscow State University Poster #5a : Wednesday : 10:00, attended for 1 hour Young Investigator Grantee Developing a New Diagnostic Tool for Small Intestinal Bacterial Overgrowth following Upper-Gastrointestinal Poster #26e : Wednesday : 10:00, attended for 1 hour Surgery Comparison of Three Automated Data Processing and Lory Hage, Imperial College London Reporting Approaches for Inborn Errors of Metabolism by LC- Young Investigator Grantee MS Flow Injection Analysis for Clinical Research Shen Luan, Thermo Fisher Scentific Poster #10b : Wednesday : 15:30, attended for 1 hour Evaluating the Stability of Breath During Storage in Thermal Endocrinology Desorption Tubes by Mass Spectrometry Oscar Ayrton, Imperial College London Poster #2d : Thursday : 12:00, attended for 1 hour Young Investigator Grantee Confident Quantification of Steroids: Analysis in Human Plasma or Serum by LC-MS/MS for Clinical Research Poster #12b : Wednesday : 15:30, attended for 1 hour Claudio De Nardi, Thermo Fisher Scientific Mass Spectrometry Techniques for Volatile Organic Compound Measurement in Cell and Organoid Media Poster #7d : Thursday : 12:00, attended for 1 hour Ilaria Belluomo, Imperial College London Analysis of Aldosterone by LC-MS/MS: Comparison between Young Investigator Grantee a Conventional Electrospray Ionization Source and a New Atmospheric Pressure Ionization Poster #13c : Thursday : 09:30, attended for 1 hour Elisa Danese, University of Verona Multi-Platform Correlation of Exhaled Volatile Organic Compounds by GC-MS, PTR-MS and SIFT-MS Poster #11a : Wednesday : 10:00, attended for 1 hour Gengping Lin, Imperial College London Measurement of Oestrone and Oestradiol by Liquid- Young Investigator Grantee Chromatography Tandem Mass Spectrometry Susan Johnston, Department of Clinical Biochemistry Poster #14c : Thursday : 09:30, attended for 1 hour Young Investigator Grantee The Effect of Concentrations of Major Metabolites on Quantification of Minor Volatile Compounds in Breath by Poster #14g : Thursday : 09:30, attended for 1 hour SESI-MS Non-classic Congenital Adrenal Hyperplasia and Polycystic Kseniya Dryahina, J. Heyrovsky Institute of Physical Chemistry Ovary Syndrome Differentiation Using a Commercially Available LCMS/MS Steroid Profile Kit: A Case Report Poster #16d : Thursday : 12:00, attended for 1 hour Ivana Marković, Osijek University Hospital Analyses of Volatile Organic Acids in Exhaled Breath Using Secondary Electrospray Ionization Mass Spectrometry (SESI- Poster #15c : Thursday : 09:30, attended for 1 hour MS) Analysis of Estrone and Estradiol to Low pg/mL Levels in Suman Som, J. Heyrovsky Institute of Physical Chemistry Human Serum by Triple Quadrupole Mass Spectrometry for Clinical Research Poster #18d : Thursday : 12:00, attended for 1 hour Zuzana Skrabakova, Thermo Fisher Scientific Analysis of Human Monocyte Volatiles by Solid-Phase Microextraction Combined with Two-Dimensional Gas Poster #21b : Wednesday : 15:30, attended for 1 hour Chromatography-Mass Spectrometry for Biomarker Discovery A Multi-Assay for the Quantification of Seven Steroid Antonio Pompeiano, Central European Institute of Technology Hormones and Precursors in Serum with LC-MS/MS Anna Lindahl, Karolinska University Hospital

19 Poster #23a : Wednesday : 10:00, attended for 1 hour Poster #23h : Thursday : 12:00, attended for 1 hour Quantitation of 17β-Estradiol and Estrone in Serum by LC- Simultaneous Measurement of 18 Steroids in Human or MS/MS Mouse Serum by LC-MS/MS to Profile the Classical and Geoffrey Rule, Millipore Sigma Alternate Pathways of Androgen Synthesis Reena Desai, University of Sydney Poster #24d : Thursday : 12:00, attended for 1 hour A Sensitive Microflow LC-MS/MS Method for the Analysis of Glycomics Corticosteroids in Human Plasma Daniel Blake, Sciex Poster #6a : Wednesday : 10:00, attended for 1 hour Site-Specific Haptoglobin N-Glycosylation Changes in Poster #25a : Wednesday : 10:00, attended for 1 hour Colorectal Cancer Development and Validation of an LC-MS/MS Method for the Jelena Simunovic, Genos Glycoscience Research Laboratory Measurement of Plasma Tryptophan, Kynurenine, Serotonin and 5-Hydroxyindoleacetic Acid Poster #12a : Wednesday : 10:00, attended for 1 hour Leanne Sheppard, Liverpool Clinical Laboratories Affinity Capture of a (Glyco)protein: Getting Your Sample Young Investigator Grantee Ready for the Mass Spectrometer Valeriia Kuzyk, VU Amsterdam/LUMC Poster #25b : Wednesday : 15:30, attended for 1 hour Young Investigator Grantee Simultaneous Determination of Cortisol and Cortisone in Saliva by LC-MS/MS: Method Validation Poster #13e : Wednesday : 10:00, attended for 1 hour Marco Bagnati, Maggiore della Carità Hospital Analysis of the Site-Specific N-Glycosylation of HeLa Cell Lysate Poster #26g : Thursday : 09:30, attended for 1 hour Simon Sugár, Hungarian Academy of Sciences Evaluation of the Updated 25-Hydroxy Vitamin D Assay on the Young Investigator Grantee Cascadion SM Clinical Analyzer Jenni Niemi, Thermo Fisher Scientific Oy Lipidomics

Poster #27c : Thursday : 09:30, attended for 1 hour Poster #3a : Wednesday : 10:00, attended for 1 hour Development of High Sensitivity Measurement of Arginine Implementation of Lipidomics in the Clinical Routine: Can Vasopressin in Human Plasma by LC-MS/MS Fluoride/Citrate Blood Sampling Tubes Improve Preanalytic Masaki Takiwaki, Chiba University Hospital Stability? Lisa Hahnefeld, Clinical Pharmacology, Goethe University Poster #27f : Wednesday : 15:30, attended for 1 hour Frankfurt Rapid UPLC-MS/MS Dried Blood Spot Analysis of Steroid Hormones for Clinical Research Poster #4c : Thursday : 09:30, attended for 1 hour Dominic Foley, Waters Corporation Lipidomic Profiling of Colorectal Cancer Cell Lines under Hypoxia Poster #27h : Thursday : 12:00, attended for 1 hour Juan Carlos Alarcon-Barrera, LUMC A Liquid Chromatography Tandem-Mass Spectrometry Young Investigator Grantee Method for Determination of 9 steroids in Human Serum for Diagnosis of CAH and Steroidogenic Biosynthesis Defects Poster #5c : Thursday : 09:30, attended for 1 hour Xiaolin Wu, Canterbury Health Laboratory Determination of Membrane Lipid Gangliosides in Human Serum and Cerebral Organoids Poster #28a : Wednesday : 10:00, attended for 1 hour Gabriela Dovrtělová, Recetox centre, Masaryk University Accuracy and Variability of Serum Bioavailable Testosterone Young Investigator Grantee Testing Methods Yusheng Zhu, Penn State University Poster #9b : Wednesday : 15:30, attended for 1 hour Development and Validation of a LC-MS/MS-based Assay for Poster #28c : Thursday : 09:30, attended for 1 hour Quantification of Polyunsaturated Fatty Acids from Human Ultra-low Level Analysis of Aldosterone in Plasma Using the Plasma and Red Blood Cells Xevo TQ-XS for Clinical Research Vlad Serafim, 'Victor Babeş' University of Medicine and Pharmacy Ben Dugas, Waters Corporation Poster #15d : Thursday : 12:00, attended for 1 hour Poster #20j : Wednesday : 15:30, attended for 1 hour Lipid Composition of Cancer-Derived Extracellular Vesicles Attempt to Develop a Fast LC-MS/MS Application for the and its Potential for the Identification of Body Fluid-Based Simultaneous Measurement of 12 Biogenic Monoamines Biomarkers for Breast Cancer diagnosis Marcel van Borren, Rijnstate Hospital Erika Dorado, Imperial College London Young Investigator Grantee Poster #22e : Wednesday : 10:00, attended for 1 hour Diagnosis of Carcinoid Tumors in the Small Intestine by LC- Poster #21c : Thursday : 09:30, attended for 1 hour MS/MS Analysis of 5-Hydroxyindoleacetic Acid (5-HIAA) in Graft Quality Assessment in Kidney Transplantation by Serum Monitoring Lipidomic Changes in the Organ During Anders Lindgren, Karolinska University Laboratory Transplantation Using Solid Phase Microextraction (SPME) Natalia Warmuzińska, Nicolaus Copernicus University in Toruń Poster #23e : Wednesday : 10:00, attended for 1 hour Young Investigator Grantee LC-MS/MS Analysis of Plasma Metanephrines Free of Interference from Midodrine and Metformin Matthew Whitlock, North West London Pathology Young Investigator Grantee

20 Poster #23b : Wednesday : 15:30, attended for 1 hour Poster #15b : Wednesday : 15:30, attended for 1 hour Plasma Lysosphingolipid Analysis by LC-Differential Mobility ‘Functional Microbiomics’ – Standardized Assessment of Spectrometry-MS/MS (LC-DMS-MS/MS): Rapid Sample Nutrition-Microbiome-Host Interplay by Targeted Preparation and Resolution of Stereoisomers Metabolomics Cyrus Papan, SCIEX Therese Koal, BIOCRATES Life Sciences AG

Metabolites & Metabolomics Poster #17a : Wednesday : 10:00, attended for 1 hour GC-MS Determination of Candidate Target Biomarkers for Poster #1d : Thursday : 12:00, attended for 1 hour Early Detection of Oesophageal Squamous Cell Cancer Targeted Metabolomics Reveals an Influence of the FTO Gene Yan Mei Goh, Imperial College London on the Kynurenine Pathway Young Investigator Grantee La-or Chailurkit, Mahidol University Poster #17c : Thursday : 09:30, attended for 1 hour Poster #2a : Wednesday : 10:00, attended for 1 hour Different Approaches for Vitamin D Determination in Enhanced Mass Spectrometric Profiling of the Human Blood Newborns by LC-MS/MS Exposome Using an Optimised Dispersive Solid Phase Rafal Rola, Nicolaus Copernicus University Extraction Protocol Young Investigator Grantee Mark David, University of New South Wales Young Investigator Grantee Poster #18c : Thursday : 09:30, attended for 1 hour Maternal Glutaric Aciduria Type 1 (GA 1) Detected Through Poster #2c : Thursday : 09:30, attended for 1 hour Newborn Screening in Croatia Detection of F-2 Mycotoxin Zearalenone in Human Urine. Ivana Križić, University Hospital Center Zagreb Consumption of Contaminated Cereal Crops or Doping Offence? Poster #19e : Wednesday : 10:00, attended for 1 hour George Madalin Danila, Romanian Doping Control Laboratory B Vitamin Reference Ranges Determination Using HPLC- Young Investigator Grantee MS/MS and Retrospective Statistical Analysis Arseny Sadykov, Scientific laboratory "Chromolab", Moscow, Poster #5b : Wednesday : 15:30, attended for 1 hour Russia Prostate Cancer Metabolic Alterations Induced by Zika Virus Young Investigator Grantee Jeany Delafiori, University of Campinas Young Investigator Grantee Poster #20a : Wednesday : 10:00, attended for 1 hour Comprehensive Clinical Acylcarnitines by LC-MS/MS Poster #6b : Wednesday : 15:30, attended for 1 hour Steve Bruce, University Hospital of Lausanne (CHUV) Biomarker Analysis by Mass Spectrometry and Artificial Intelligence Techniques of Obese Human Plasma Poster #20c : Thursday : 09:30, attended for 1 hour Flávia Luísa Dias Audibert, University of Campinas Solid Phase Microextraction (SPME) in Kidney Examination – Young Investigator Grantee LC-MS/MS-based Identification of Potentially Significant Metabolites in Graft Quality Assessment Poster #9a : Wednesday : 10:00, attended for 1 hour Iga Stryjak, Nicolaus Copernicus University in Toruń Simple and Rapid Tandem Mass Spectrometry Method for the Young Investigator Grantee Analysis of Methylmalonic Acid in Urine Michel Boutin, Université de Sherbrooke Poster #22c : Thursday : 09:30, attended for 1 hour Analysis of Changes in Bile Acids Concentration in Bile in Poster #9d : Thursday : 12:00, attended for 1 hour Response to the Degree of Liver Ischemia and the Method of Serum Biomarkers of Chemoradiosensitivity in Esophageal Organ Preservation Cancer is Identified by the Targeted Metabolomics Approach Kamil Łuczykowski, Nicolaus Copernicus University in Toruń Masaru Yoshida, Kobe University Graduate School of Medicine Young Investigator Grantee

Poster #10c : Thursday : 09:30, attended for 1 hour Poster #26a : Wednesday : 10:00, attended for 1 hour Method Development of Amino Acid Analysis in a Dried Blood Pharmacometabolomic Study of Novel Multitarget Drugs Spot for the Second-Tier Test in the Newborn Screening Based on Natural Prostaglandins in Terms of Therapeutic Program Effectiveness Zahra Talebpour, Department of chemistry, Alzahra University Kseniia Shestakova, University of Verona, Sechenov University

Poster #11b : Wednesday : 15:30, attended for 1 hour Poster #26c : Thursday : 09:30, attended for 1 hour Metabolomic Barometer of Gestational and Postpartum Evaluation of an Artificial Serum as a Surrogate Matrix for Weight in Overweight Pregnant Women Calibration Samples for a Preeclampsia Risk Prediction Test Chung-Ho E. Lau, Imperial College London Anna Catharina Suhr, Metabolomic Diagnostics Young Investigator Grantee Poster #26f : Wednesday : 15:30, attended for 1 hour Poster #13d : Thursday : 12:00, attended for 1 hour Advancement of the Quantitative Measurement of Enzyme Establishment of a Liquid-Chromatography Tandem Mass- Activities in Six Lysosomal Storage Disorders via LC-MSMS Spectrometry Method for Vitamin D Metabolites to Detect 24- Mietha Magdalena van der Walt, Human Metabolomics, North- Hydroxylase Deficiency West University, SA Sieglinde Zelzer, Medical University Graz

21 Poster #27b : Wednesday : 15:30, attended for 1 hour Poster #12d : Thursday : 12:00, attended for 1 hour Comparison of Phenylketonuria Screening with a Fluorimetric Separation of Intact Parathyroid Hormone and Variants Using Method and with Tandem Mass Spectrometry a Highly Sensitive Sheathless CE-ESI-MS/MS Method Vanja Cuk, University Children's Hospital Laurent Nyssen, University of Liège Young Investigator Grantee Poster #13a : Wednesday : 10:00, attended for 1 hour Poster #27d : Thursday : 12:00, attended for 1 hour Quantitative Determination of Human IgA Subclasses and Untargeted Metabolomic Profiling of Plasma Samples of their Fc-Glycosylation Patterns in Human Plasma by Using Patients with MBOAT7 Gene Defect Peptide Analogue Internal Standard and UHPLC-MS/MS Basri Gülbakan, Hacettepe University Hsiao-Fan Chen, Taipei Medical University Young Investigator Grantee Poster #27g : Thursday : 09:30, attended for 1 hour Tandem Mass Spectrometry-based Analysis Reveal Poster #14b : Wednesday : 15:30, attended for 1 hour Relationship between Active DNA Demethylation and Krebs LC-MS-based Pharmacokinetics of Insulin Aspart Measured in Cycle in AML and MDS Individuals with Type 2-Diabetes During Operation Closed- Justyna Szpotan, Collegium Medicum in Bydgoszcz Loop Glucose Control Young Investigator Grantee Jean-Christophe Prost, Bern University Hospital

Poster #28f : Wednesday : 15:30, attended for 1 hour Poster #15a : Wednesday : 10:00, attended for 1 hour Simultaneous Quantitation of Diabetes Markers and Confident Protein and Peptide Identification with Mass Comprehensive Metabolome Annotation Achieved via Semi- Spectrometry: Understanding and Exploiting Collision Energy targeted Analysis of Serum Samples Dependence Ioanna Ntai, Thermo Fisher Scientific Agnes Revesz, Research Centre for Natural Sciences, HAS Young Investigator Grantee Poster #20k : Thursday : 09:30, attended for 1 hour Serum Metabolomics Using LC-MS Reveals Potential Poster #16c : Thursday : 09:30, attended for 1 hour Biomarker of Myocardial Ischemia Expression of Cellular and Neurodevelopmental Markers in Sunhee Jung, Korea Basic Science Institute Cerebral Organoids Marketa Nezvedova, Masaryk University Microbiology Poster #17b : Wednesday : 15:30, attended for 1 hour Poster #7b : Wednesday : 15:30, attended for 1 hour Peptide Sequencing with Top-Down Synthesized TiO2 Enterobacter: When MALDI-TOF (VITEK® MS) and New Nanowires Using Laser Desorption/Ionization Time-of-Flight Taxonomy Speak as One Voice Mass Spectrometry Valérie Monnin, bioMérieux Tae Gyeong Yun, Yonsei University Young Investigator Grantee Poster #11f : Wednesday : 15:30, attended for 1 hour Improvement of the Experimental and Informatic Pipeline for Poster #17d : Thursday : 12:00, attended for 1 hour High-Throughput MS/MS Proteotyping of Pathogens Prognostic Potential of Combined Omics Analysis for Karim Hayoun, CEA Diagnostics of Azoospermia Alexnder Brzhozovskiy, National Medical Research Center for Poster #16b : Wednesday : 15:30, attended for 1 hour Obstetrics Monitoring of Human Procalcitonin by Functionalized MALDI Young Investigator Grantee Surfaces Josef Dvorak, Department of Biochemistry, Charles University Poster #18a : Wednesday : 10:00, attended for 1 hour Single-Shot Targeted Proteomics Flavivirus Assay Poster #19c : Thursday : 09:30, attended for 1 hour Jayantha Gunaratne, Institute of Molecular and Cell Biology, Detection of Carbapenemase-producing Organisms via A*STAR MALDI-TOF Narae Hwang, Kyungpook National University Poster #20d : Thursday : 12:00, attended for 1 hour Development of a Sensitive Mass Spectrometric Method for Proteins & Proteomics the Quantification of Procalcitonin Sebastian-Alexander Tölke, Hochschule Fresenius, Germany Poster #2b : Wednesday : 15:30, attended for 1 hour Semi-Automated Positive Pressure SPE for Proteomics Poster #20e : Wednesday : 10:00, attended for 1 hour Christian Scherling, Tecan Exploring Optimal Protein Identification and Repeatability via Sequences of Fine-Tuned LC-MS/MS Runs Poster #9c : Thursday : 09:30, attended for 1 hour Márton Gyula Milley, RCNS, Hungarian Academy of Sciences Mass Spectrometry Studies of Glutathione S Transferase P1 Young Investigator Grantee Protein and Gene and 5-Methylcytosine Level in Acute Lymphoblastic Leukemia Poster #22d : Thursday : 12:00, attended for 1 hour Alireza Ghassempour, Shahid Beheshti University Data-Independent Acquisition Spiked with QconCAT Quantification Standards (DISQ):An Alternative to Targeted Poster #11d : Thursday : 12:00, attended for 1 hour Methods? Developing the Research to Routine Workflows with FAIMS: Florian Christoph Sigloch, PolyQuant GmbH Automating Large-Scale SRM Method Creation for Routine Plasma Proteomics Screening Paul Humphrey, ThermoFisher Scientific

22 Poster #25c : Thursday : 09:30, attended for 1 hour Small Molecules / Tox / TDM Development and Comparison of Two High-throughput LC-MS Methods for the Accurate Quantitation of IGF1 in Human Poster #1a : Wednesday : 10:00, attended for 1 hour Serum The Effect of Sample Tube Type, pH, Storage Time and Anders Fridström, Merck Sweden AB Temperature on Antihypertensive Non-Adherence Results by Quantitative LC-MS/MS Poster #26b : Wednesday : 15:30, attended for 1 hour Aneela Iqbal, Leicester Royal Infirmary High-Field Asymmetric Waveform Ion Mobility Spectrometry Young Investigator Grantee (FAIMS) - Parallel Reaction Monitoring (PRM) for HER2 Protein Quantitation in Tumor Biopsies Poster #1c : Thursday : 09:30, attended for 1 hour Steve Sweet, AstraZeneca Influence of Saw Palmetto and Pygeum Africana Extracts on the Urinary Concentration of Anabolic Androgenic Steroids Poster #27a : Wednesday : 10:00, attended for 1 hour Francesco Botre, "Sapienza" University of Rome & Antidoping Lab Characterizing the Novel Metastatic Regulator in CRPC-based FMS on Quantitative Proteomics Do Eun Kim, College of Pharmacy, Kyungpook National Poster #3b : Wednesday : 15:30, attended for 1 hour University Simultaneous Determination of Vitamins B1, B2 and B6 in Whole Blood by LC-MSMS Poster #27e : Wednesday : 10:00, attended for 1 hour Stefanie Wernisch, Waters GmbH SCOUT Rtbeads, A Useful Tool for LC-MS Retention Time Control: A Relevant Application for Multiplex LC SRM Poster #5d : Thursday : 12:00, attended for 1 hour Biomarker Quantitation Simple and High-throughput LC-MS/MS Method for Chloe Bardet, ANAQUANT Simultaneous Measurement of Five Smoking-related Metabolites in Urine Poster #28b : Wednesday : 15:30, attended for 1 hour Mi ryung Chun, Samsung Medical Center Incorporating Stable Isotope-Labeled IgG Internal Standard and Affinity Purification for Analyzing Human IgG4 and Fc- Poster #6c : Thursday : 09:30, attended for 1 hour glycan Profiles by UHPLC-MS/MS High-throughput Quantification of Immunosuppressant Drugs Isabel I-Lin Tsai, Taipei Medical University in Human Blood by LC-MSMS for Clinical Research Magnus Olin, Thermo Fisher Scientific Poster #28d : Thursday : 12:00, attended for 1 hour Direct Monitoring of Fucosylated Glycopeptides of Alpha- Poster #6d : Thursday : 12:00, attended for 1 hour Fetoprotein in Hepatocellular Carcinoma Serum by LC-MS/MS Validated High-Sensitive Steroid Profiling in Human Serum with Immunoprecipitation Using LC-MS/MS Kwang Hoe Kim, Korea Basic Science Institute Stephane Moreau, SFP

Poster #20m : Thursday : 12:00, attended for 1 hour Poster #8b : Wednesday : 15:30, attended for 1 hour High-Throughput PEAKS Workflow and SPIDER Algorithm for Towards a LC-MS/MS Method for the Quantification of Serum Large Scale Clinical Proteomics and Variant Identification Symmetric Dimethylarginine and Asymmetric Using PEAKS Online X Dimethylarginine for Use in a Routine Clinical Laboratory Jonathan Krieger, Bioinformatics Solutions Inc David Marshall, Manchester University NHS Foundation Trust Young Investigator Grantee Quality Management & Standardization Poster #8c : Thursday : 09:30, attended for 1 hour Poster #4b : Wednesday : 15:30, attended for 1 hour Direct Quantification of Amino Acids in Human Plasma by LC- Development of a Candidate Higher Order Reference MS/MS Measurement Procedure for the Analysis of Metanephrines in Valérie Thibert, Thermo Scientific France Plasma Using Micro-Flow LC-MS/MS Dima AlMekdad, King's College London Poster #8d : Thursday : 12:00, attended for 1 hour Young Investigator Grantee Simultaneous Determination of 14 Antiretroviral Drugs in Plasma by micro-LC-MS/MS for Therapeutic Drug Monitoring Poster #10a : Wednesday : 10:00, attended for 1 hour Isabela Tarcomnicu, National Institute of Infectious Diseases "Prof. Intact-Cell Mass Spectrometry for Monitoring of Stem Cells Dr. Matei Bals" Cultures Petr Vanhara, St. Anne's University Hospital Brno, Czech Poster #10d : Thursday : 12:00, attended for 1 hour Republic Untargeted Data Independent Acquisition Analysis of Drugs of Abuse by LC-MS/MS, a Generic Approach for Routine Poster #11e : Wednesday : 10:00, attended for 1 hour Clinical Pathology Screening Methodological Traceability: Standardized Description of LC- Emily Armitage , Shimadzu Corporation MS-based Measurement Methods in Laboratory Medicine Carina Schus ter, LMU Munich Poster #11c : Thursday : 09:30, attended for 1 hour Fast Multiplexed Analysis of Cannabinoids and their Poster #21e : Wednesday : 10:00, attended for 1 hour Metabolites in Urine Using MassHunter StreamSelect LC-MS Collision-energy breakdown curves – an additional tool to System characterize MS/MS methods Moritz Wagner, Agilent Technologies Sophie Mörlein, University Hospital, LMU Munich

23 Poster #12c : Thursday : 09:30, attended for 1 hour Poster #20i : Wednesday : 10:00, attended for 1 hour Development and Evaluation of a LC-MS/MS Method for the Drugs of Abuse Screening and Quantification Directly from Quantitation of Isavuconazole in Human Serum Samples Urine Using Paperspray Technology Andreas Meinitzer, Medical University Graz Shawnna Donop, ThermoFisher Scientific

Poster #13b : Wednesday : 15:30, attended for 1 hour Poster #21a : Wednesday : 10:00, attended for 1 hour LC-MS/MS Method for Screening of Intoxication and Drug Simultaneous Quantitation of Controlled-Substances/Pain- Adherence of Angiotensin Converting Enzyme Inhibitors in Management Drugs in Oral Fluids via Coated Blade Spray- Plasma Tandem Mass Spectrometry Mohsin Ali, Institute of Clinical Pharmacy and Pharmacotherapy Frances Carroll, Restek Corporation Young Investigator Grantee Poster #22b : Wednesday : 15:30, attended for 1 hour Poster #14a : Wednesday : 10:00, attended for 1 hour Phospholipid Removal from Protein Precipitated Plasma Implementation of Triple Quadrupole LC-MS/MS Complete Using In-Line Sample Preparation (ILSP) Kits on a High Resolution Mass Spectrometer – Limitations Christian Weyer, Restek Corporation and Benefits Katharina Kern, RECIPE Chemicals + Instruments GmbH Poster #23c : Thursday : 9:30, attended for 1 hour Performance of Common Methods When Assessing Protein- Poster #14d : Thursday : 12:00, attended for 1 hour Binding in Low-Protein and Low-Volume Samples Fully-Automated LC-MS Method for Uracil and Dihydrouracil Reingard Raml, Joanneum Research Institute in Human Plasma Doriane Toinon, Shimadzu France Poster #23d : Thursday : 12:00, attended for 1 hour Evaluation of Simplified Workflows for Hair Matrix Extraction Poster #14f : Wednesday : 15:30, attended for 1 hour Prior to UHPLC-MS/MS Analysis A Fast and Robust Method for the Quantification of Alan Edgington, Biotage GB Limited Venetoclax by LC-MS/MS Regula Steiner, University Hospital Zürich Poster #25e : Wednesday : 10:00, attended for 1 hour LC-MS/MS Analysis of Plasma Epinephrine and Poster #14h : Thursday : 12:00, attended for 1 hour Norepinephrine A High-throughput LC-MS/MS Method for Vitamin A and Marianne Bergmann, Lillebaelt Hospital Vitamin E Helge Berland, Hormone Laboratory, Haukeland University Poster #26d : Thursday : 12:00, attended for 1 hour Hospital Impact of Body Mass Index on Cytochrome P450 3A Phenotype in Obese Patients Poster #18b : Wednesday : 15:30, attended for 1 hour Birgit M. Wollmann, Diakonhjemmet Hospital, Oslo, Norway Simultaneous Determination of Antihypertensive Drugs in Serum by LC-MS/MS Poster #28e : Wednesday : 10:00, attended for 1 hour Karolina Kotalova, Spadia LAB a.s. New Solutions Applied in Oral Fluid Drug Testing: Fine- Tuning and Optimization of the SPME-LC-MS Method Poster #19b : Wednesday : 15:30, attended for 1 hour Łukasz Sobczak, Dept of Pharmacodynamics and Molecular Integrated Toxicological Screening and Confirmation Analysis Pharmacology, Faculty of Pharmacy, Collegium Medicum in with Stable 24/7 Availability Bydgoszcz at Nicolaus Copernicus University in Toruń Frank Streit, UMG Goettingen, Germany Young Investigator Grantee

Poster #19d : Thursday : 12:00, attended for 1 hour Poster #28g : Thursday : 09:30, attended for 1 hour Determination of Biomarkers of Organophosphorus Agent Reversed-phase UPLC-MS/MS Analysis of Plasma Intoxication by Ion Chromatography and Tandem Mass Catecholamines and Metanephrines for Clinical Research Spectrometry Gareth Hammond, Waters Corporation Igor Rodin, Lomonosov Moscow State University Poster #28h : Thursday : 12:00, attended for 1 hour Poster #20b : Wednesday : 15:30, attended for 1 hour Confirmation Method for the Determination of Drugs of Abuse An LC-MS/MS Method for Simultaneous Measurement of Five in Saliva: Validation of a RUO Kit by LC-MS/MS, Ready for Antimicrobial Drugs (Vancomycin, Gentamicin, Amikacin, Use. Linezolid and Teicoplanin) for TDM Ugo de Grazia, Fondazione IRCCS Istituto Neurologico Carlo Antonio Martini, ASST OVEST MILANESE;CLINICAL LAB. Besta Legnano Hospital Poster #21f : Wednesday : 15:30, attended for 1 hour Poster #20f : Wednesday : 15:30, attended for 1 hour Validation of a LCMS Assay for Citrulline Suitable for Daily A UHPLC-MS/MS Method for the Simultaneous Quantification Routine Through an Original MRM Approach of Ten Directly Acting Anti-HCV Drugs in Patient Plasma Claude Hercend, Aphp Hupnvs, UF de Biochimie Clinique, Hopital Amedeo De Nicolò, University of Turin Bichat

Poster #20h : Thursday : 12:00, attended for 1 hour Poster #21h : Thursday : 12:00, attended for 1 hour Automated Sample Pretreatment for the Analysis of Synthetic Development and Validation of the First UHPLC-MS/MS Cannabinoids in Urine with LC-MS/MS Method for the Quantification of the New Anti-Ebola Drug Stefan Eckelt, Labor Berlin Remdesivir: Application to Healthy Volunteers Valeria Antonio D, University of Turin

24 Poster #22f : Wednesday : 15:30, attended for 1 hour Troubleshooting Developing an LC-MS/MS Method for 29 Antihypertensive Drugs in Urine Poster #24a : Wednesday : 12:30, attended for 15 min Melissa McNaughton, NHS The Hurdles of Developing an LC-MS/MS Assay for Desmosine, a Biomarker for Elastin Degradation Poster #23f : Wednesday : 15:30, attended for 1 hour Jody van den Ouweland, Canisius-Wilhelmina Hospital LC-MS/MS Measurement of Phosphatidylethanol (PEth 16:0/18:1) and Drugs of Abuse Applying Volumetric DBS Poster #24b : Wednesday : 12:45, attended for 15 min Device Fast and Efficient Method for Detection and Quantification of Gökçe Göksu Gürsu, Sem Laboratuar Cihazları Pazarlama San. Catecholamines in Human Plasma by LC-MS/MS - Ve Tic A.Ş Troubleshooting Chiara Calaprice, University hospital of Liege Poster #23g : Thursday : 09:30, attended for 1 hour Young Investigator Grantee Performance of the Cascadion SM Immunosuppressants Panel on the Cascadion SM Clinical Analyzer Poster #24c : Wednesday : 13:00, attended for 15 min Mari Kiviluoma, Thermo Fisher Scientific Oy Matrix Dilemmas in LC-MS/MS: The Use of Appropriate Calibrators and Internal Standards to Facilitate Acceptable Tissue Imaging Criteria for Quantification Tania Grobler, North-West University Poster #1b : Wednesday : 15:30, attended for 1 hour Brain Tumour Characterization Using Laser Desorption Various Other Imaging – Rapid Evaporative Ionisation Mass Spectrometry Hanifa Koguna, Imperial College London / NPL Poster #7c : Thursday : 09:30, attended for 1 hour Young Investigator Grantee Rapid Evaporative Ionisation Mass Spectrometry (REIMS): A Diagnostic Tool for Omental Metastases in Patients with Poster #3d : Thursday : 12:00, attended for 1 hour Primary Ovarian Cancer Probing Aβ Dynamics in APP Knock-In Mice and in Eftychios Manoli, Imperial College London vitro Using Stable Isotope Labelling and MALDI Imaging Mass Young Investigator Grantee Spectrometry, and Examining the Role of Microglia Katie Stringer, University College London Poster #11g : Thursday : 09:30, attended for 1 hour Young Investigator Grantee Fully Automated LC-MS/MS Analysis of Anticoagulants Using a Novel Reagent Kit Poster #4d : Thursday : 12:00, attended for 1 hour Franck Chevallier, Alsachim Pyroglutamation of Amyloid-β-42 (Aβ1-42) Followed by Aβ1- 40 Deposition Underlies Plaque Polymorphism in Progressing Poster #14e : Wednesday : 10:00, attended for 1 hour Alzheimer’s Disease Pathology Confident Quantitation of 25-Hydroxyvitamin D2 and D3 in Jörg Hanrieder, University of Gothenburg Human Plasma for Clinical Research by LC-MSMS Mariana Barcenas, Thermo Fisher Scientific Poster #13f : Wednesday : 15:30, attended for 1 hour MALDI-TOF MSI of MeLiM Melanoma: Searching for Poster #14i : Wednesday : 10:00, attended for 1 hour Differences in Protein Profiles Analysis and Characterization Modified in vitro Transcribed Lucie Vanickova, Mendel University in Brno RNA Using LC-MS/MS Method Dominika Strzelecka, Faculty of Physics, University of Warsaw Poster #21d : Thursday : 12:00, attended for 1 hour Cross-modality Single-pixel Correlation of Multimodal Poster #16a : Wednesday : 10:00, attended for 1 hour Imaging Mass Spectrometry of Prostate Cancer Prednisone and Prednisolone Detection in Urine Samples: A Ambra Dreos, Sahlgrenka Academy at the University of GC-C-IRMS Method to Discriminate Exogenous or Gothenburg Endogenous Origin Loredana Iannella, Laboratorio Antidoping, FMSI Poster #22a : Wednesday : 10:00, attended for 1 hour Exploring Healthy and Tumor Tissue Microenvironment with Poster #19f : Wednesday : 15:30, attended for 1 hour Immuno-Oncology Markers Using Multiplexed Hyperion Targeted MMulti-OMICS: Rapid Plasma Profiling of a Bladder Imaging System and Lung Cancer Human Cohort Roberto Spada, Fluidigm Billy Molloy, Waters

Poster #21g : Thursday : 09:30, attended for 1 hour Poster #25d : Thursday : 12:00, attended for 1 hour Mass Spectrometric Imaging of Cysteine Rich Proteins in Integration of Mycophenolate and its Metabolite Analysis in Human Skin Plasma Using LC-MS/MS with Full-Automated Sample Tomas Do, Mendel University Preparation Fanny Dayot, Alsachim

Poster #22g : Thursday : 09:30, attended for 1 hour Validation of the Doubly-labelled Water Method to Determine Total Energy Expenditure in a Rat Model Anita Eberl, Joanneum Research

25

Exhibitor Summaries

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Immundiagnostik (Mini-Table Row) Chromsystems (Booth #8) http://www.immundiagnostik.com http://www.chromsystems.com Immundiagnostik AG (www.immundiagnostik.com), founded in 1986 by Dr. Franz Chromsystems is a leading global company providing ready-to-use kits, multilevel Paul Armbruster (CEO), is specialized on the development, production, and calibrators and quality controls for routine clinical diagnostics by LC-MS/MS and world-wide distribution of innovative parameters and detection methods for 26 laboratory diagnostics and medical research. The main focus is the development mass spectrometry technology to clinical testing laboratories. Oering an of immunological tools, of HPLC and molecular biology methods, and of new expanding portfolio of mass spectrometry based solutions and assays for in vitro applications for mass spectrometry (LC-MS/MS). Immundiagnostik concentrates diagnostic use, SCIEX Diagnostics enables customers to deliver high quality on the development and production of laboratory diagnostics for the identi ca- diagnostic information to clinicians who make decisions aecting patient care. tion of disease risks, for dierential diagnosis, and for therapeutic drug monitor- ing. The company holds a particularly strong portfolio in markers of oxidative Shimadzu Booth #1-3 stress/anti-aging, gastroenterology and nutrition, skeletal system, and cardio-re- https://www.shimadzu.eu no-vascular system. Immundiagnostik owns more than 35 patents in Europe, the Since its creation in 1875, Shimadzu has been a worldwide leading manufacturer US, Japan, Canada, and Australia, is certi ed according to DIN EN ISO 13485 and of analytical instrumentation. Our technologies are constantly driven by ful lls the requirements of the German Medical Device Regulation and the EU IVD innovative thinking and new ideas, developing tools to deliver meaningful data Regulations (98/79 EG). and to help create better science. In the clinical research eld, our mass spectrometry platforms in GC-MS, GC-MS/MS, LC-MS/MS and MALDI-TOF do more Merck (Booth #4) by bringing together robust, reliable detection together with UFMS (Ultra-Fast http://www.sigmaaldrich.com/clinical Mass Spectrometry) opening up new opportunities in identifying/quantifying The life science business of Merck combines strong innovative R&D teams with a more compunds with greater accuracy and certainty. At MSACL 2019 EU, we will global network spanning more than 60 countries and 70 manufacturing sites. show our technologies and workows for clinical-based research including the Innovations include BioSPME for rapid extraction from biological matrices for new benchtop MALDI-8020. Visit our booth and attend our vendor seminar to LC/MS or direct MS, in-line SPE cartridges for eective extraction and phospholip- discover all the bene ts of UFMS technologies! id removal and the latest developments in monolith and fused core HPLC column technologies, all of which can be seen on booth 4. The company provides a Tecan (Booth #26) product portfolio of 300,000 products, including over 20,000 reference materials, http://www.tecan.com along with Cerilliant Certi ed Reference Materials, all with easy access to Tecan (www.tecan.com) is a leading global provider of laboratory instruments comprehensive data through one of the most advanced web platforms. and solutions in biopharmaceuticals, forensics and clinical diagnostics. The company specializes in the development, production and distribution of PerkinElmer (Booth #27-28) automated workow solutions for laboratories in the life sciences sector. Its http://www.perkinelmer.com clients include pharmaceutical and biotechnology companies, university research PerkinElmer is the global market leader in neonatal screening, currently serving departments, forensic and diagnostic laboratories. As an original equipment customers in more than 100 countries. We are a total solution provider oering manufacturer (OEM), Tecan is also a leader in developing and manufacturing OEM complete systems based on a broad range of high quality, validated products, instruments and components that are then distributed by partner companies. including newborn screening kits, consumables, instruments and software. Founded in Switzerland in 1980, the company has manufacturing, research and PerkinElmer is proud to oer the QSight 220 for Clinical Research System for use development sites in both Europe and North America and maintains a sales and in Clinical Research environments that require sensitivity, robustness and reduced service network in 52 countries. In 2017, Tecan generated sales of CHF 548 million downtime. Come visit us at booth 25 to learn more! (USD 560 million; EUR 494 million). Registered shares of Tecan Group are traded on the SIX Swiss Exchange (TECN; ISIN CH0012100191). Pharma uidics (Booth #22) https://www.pharmauidics.com Thermo Fisher Scientic (Booth #14-16) Game-changing technology PharmaFluidics introduces the silicon revolution in http://www.thermoscientic.com/msacleu chromatography. The perfect order of the micro-Chip Pillar Arrays overcomes the Thermo Fisher Scienti c Inc. is the world leader in serving science, with revenues physical limits of any packed bed alternative. The revolutionary redesign of the of $17 billion and approximately 50,000 employees in 50 countries. Our mission is HPLC separation bed reduces peak dispersion to an absolute minimum. We to enable our customers to make the world healthier, cleaner and safer. We help supply micro-Chip Liquid Chromatography cartridges for use in all standard our customers accelerate life sciences research, solve complex analytical nano-LC equipment Whether you are analyzing trace amounts of compounds in challenges, improve patient diagnostics and increase laboratory productivity. complex mixtures, or looking for subtle modi cations in biological molecules: use Through our premier brands – Thermo Scienti c, Applied Biosystems, Invitrogen, plug-and-play µPACTM cartridges to boost your biomarker and life sciences Fisher Scienti c and Unity Lab Services – we oer an unmatched combination of research. innovative technologies, purchasing convenience and comprehensive support. For more information, please visit www.thermo sher.com. RECIPE Chemicals + Instruments (Booth #17) https://recipe.de/ UTAK Laboratories (Booth #25) Starting business in 1982, RECIPE is one of the leading companies in HPLC and http://www.utak.com LC-MS/MS diagnostics today. For mass spectrometry, RECIPE oers CE/IVD At UTAK, we’re proud to call ourselves “control freaks”, but not in the way you labelled ClinMass® LC-MS/MS Complete Kits. Furthermore, several reagents such might think. That’s because our obsession lies not in taking control but in giving as ClinMass® Optimisation Mixes and Internal Standards, ClinCal® Calibrators and control—to the testing labs that need the nest quality control materials for their ClinChek® Controls are available for a reliable and standardised LC-MS/MS clinical and forensic toxicology test methods. Our close-knit group crafts the analysis. All products are developed and produced in our state-of-the-art quality controls these labs depend upon for every kind of analysis, including a production plant in Munich. RECIPE is recognised worldwide as a reliable partner wide range of comprehensive stock controls in urine, serum, blood, oral uid and for clinical laboratories and is certi ed by the quality management standard EN more, as well as starting matrices for laboratories seeking to develop in-house ISO 13485. quality control material. We also create personalized control solutions to support the new methods these labs develop. Our dedication is grounded in our belief Restek (Booth #9) that better control for testing labs leads to more accurate results and ultimately, http://www.restek.com to better safeguarding of health and safety standards. A leading innovator of chromatography solutions for both LC and GC, Restek has been developing and manufacturing columns, reference standards, sample Waters (Booth #12-13) preparation materials, accessories, and more since 1985. We provide analysts http://www.waters.com/waters/eventInstance.htm?eiid=134989704 around the world with products and services to monitor the quality of air, water, Waters Corporation, the premium brand in the analytical instruments industry, soil, food, pharmaceuticals, chemicals, and petroleum products. Our experts have creates business advantages for laboratory-dependent organizations by diverse areas of specialization in chemistry, chromatography, engineering, and delivering practical and sustainable scienti c innovation to enable signi cant related elds as well as close relationships with government agencies, interna- advancements in healthcare delivery, environmental management, food safety, tional regulators, academia, and instrument manufacturers. www.restek.com and water quality worldwide. Bringing keen understanding and deep experience to those responsible for laboratory infrastructure and performance, Waters helps SCIEX (Booth #6) customers make profound discoveries, optimize laboratory operations, deliver http://www.sciex.com product performance, and ensure regulatory compliance. Pioneering a connected SCIEX’s global leadership and world-class service and support in the capillary portfolio of separations and analytical science, laboratory informatics, mass electrophoresis and liquid chromatography-mass spectrometry industry have spectrometry, as well as thermal analysis, Waters’ technology breakthroughs and made it a trusted partner to thousands of the scientists and lab analysts laboratory solutions provide an enduring platform for customer success. worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. As part of AB SCIEX, SCIEX Diagnostics brings the power, exibility, reliability, and accuracy of 27 Exhibit Hall Map

MINI-TABLES BT Bistro Table BT BT BT BT BT 11 a Immundiagnostik Capitainer Biocrates Fossil Ion Fluidigm b d c Tech d c d c d c d c S TAIRCASE 2 03 Poster Boards c 07 08 09 10 BT a b a b a b a b a b d BT BT BT e Booth Space d c Food & Beverage Food 06 f a b 01 02 03 g S TAIRCASE 3 GOLD d c Shimadzu 158 05 a b Biotage AB 12 a BT Merck SCIEX AUTHORITY’S d c Sweden b 04 ROOM a b 04 05 06 c BT d d c BT BT BT 03 09 10 11 BT a b Eureka 13 a b c d e f 08 Hamilton Food & Beverage Lab Restek Bonaduz BRONZE d c Division c fe igh Chromsystems 02 BT BT b a b GOLD Fornax 14 a Recipe Thermo Fisher Scienti c Technologies GOLD d c Waters 01 14 15 16 17 18 12 13 a b BT BT E SCALA TOR d c d c d c MINI-TABLE BT 15 BT 16 BT 17 0 6m 19 20 POSTERS a b a b a b BT SILVER BT AFFINISEP Agilent d c h BT 23 18 Cambridge Bioinformatics a b g 104 m 20 h Isotope Pharmauidics 20 a Solutions f b k j g Labs BT e e 21 22 c d fe igh BT 9m f d d BT BT e BT 19 c c a 100 d 25 26 BT f e d c b b c b a 28 UTAK Tecan b a 25 27 a BT 1ST FLOOR KITCHEN 205 Meet-a-Mentor Perkin Elmer FL top 700 Rally Point E SCAPE ROUTE b26 a b26 c d fe g 27 28 d c h g d c h g d c h g d c 24 23 23 22 22 21 21 Food & Beverage Food FL bottom a b e f a b e f a b e f a b S TAIRCASE 1

BT BT BT BT

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28 Session Room Map

5th Floor Ground Floor :: Tracks 1-3 Out elevator and straight back to end of hall LOADING DOOR S TAIRCASE 2 Trapp S TAIRCASE 4 *5th Floor*

S TAIRCASE 3 4th Floor 1 Track2 1 3 G OODS LIFT / REIGHT ELE VATO R

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TAIRCASE Mozart 1-3 S HOP

C ATERING S TAFF Track 6 LIFT

5 LIFT Doppler MOZAR T HALL S HOP *4th Floor* Track 2 Mozart 4-5 S HOP rd 3 Floor S HOP

S HOP Track 5 TRANSIT S HERA TO N

Trakl R *3rd Floor* AINERSTRASSE S HOP REGISTRATION I I E SCALA TOR DESK

2nd Floor Registration Foyer S TAIRCASE 1 Track 3 P AY DESK

LIFT LIFT Track 4 Papageno LIFT Paracelsus *2nd Floor*

433 433 433 Main Entrance

29 Exhibitors

GOLD SPONSOR LEVEL

SILVER SPONSOR LEVEL BRONZE SPONSOR LEVEL

And special thanks to AFFINISEP Hamilton Bonaduz Biocrates Life Sciences Immundiagnostik Bioinformatics Solutions Merck Biotage AB, Sweden PerkinElmer Cambridge Isotope Labs Pharmauidics Capitainer RECIPE Chemicals + Instr Eureka Lab Division Restek for their continued Fluidigm SCIEX support of the Fornax Technologies Tecan Educational Grant Program Fossil Ion Technology UTAK Laboratories

Supporting Societies

30 Call for Abstracts for Scientific Sessions on: Also accepting Case Studies on all topics. Microbiology Data Science Imaging MS Applications of MALDI MS Machine Learning Biomarkers New & Experimental Approaches Practical Tools In the Clinic Anti-Microbial Resistance R Showcase Informatics Best Practices Translational Research Tox / TDM / Endo Therapeutic Targets Clin Apps of TDM & Pharmacokinetics Applications & Strategies Cannabis / Hemp / Natural Products Proteomics Imaging Hardware / Tech Urine & Oral Fluid Drug Testing Data-independant Acquisition Forensic Tox & Drug ID Reference Method Procedures Functional Assays & HTS Post-trans Modifications Metabolomics Beyond Serum/Plasma Therapeutic Antibodies Translation Est. 2008 Lipidomics Tissue (Quantitative) Large Cohorts Microsampling Multi-omic Analysis Intact Proteins Podium due by Nov 13 Untargeted Profiling New Assays Poster due by Feb 20 New Techniques & Approaches

31 MassTox ® Drugs of Abuse Testing in Urine by LC-MS/MS

Target screening of more than 100 drugs in a single run

Substances: amphetamines • barbiturates • ­benzodiazepines • booster ­cannabinoids • cocaine • opiates/opioids • z-drugs and others

Quantitative confirmation within the same run Simple sample preparation Great selectivity and sensitivity through high peak resolution Internal standards for nearly all analytes

Learn more: www.chromsystems.com/doa

Chromsystems Instruments & Chemicals GmbH Am Haag 12 • 82166 Gräfelfing/Germany Phone: +49 89 18930-0 • [email protected] Unbelievably Powerful, Remarkably Small Take your clinical research to new heights with Agilent’s affordable, space-saving Ultivo LC/MS Triple Quad.

or starters the U t vo offers more f ex b ty w th the new e ectrospray on zat on (ES ) conf gurat on

You can a so take advantage of enhanced data ntegr ty too s p us features that he p your ab comp y w th 21 C R Part 11 requ rements And w th new ear y ma ntenance feedback capab t es U t vo s even more user fr end y

W th more opt ons than ever U t vo s the c ear cho ce for your ab

See how U t vo enab es prec se h gh throughput quant tat on www.agilent.com/chem/Ultivo

For Research Use Only. Not for use in diagnostic procedures.

© Agilen echnologies, nc 2019 [ MSACL EUROPE 2019 ] Booths 12 & 13 September 24–26 ¡ Salzburg Congress Center, Salzburg, Austria MSACL 6th European Congress and Exhibition

MEET WITH YOUR LC-MS PARTNER! Discover how Waters analytical technology for better care can make your laboratory more efficient and find out: ■ The importance of reliable and compliant LC-MS instrumentation for the clinical laboratory JOIN OUR WORKSHOP ■ How to get cleaner samples for better results ■ How to acquire accurate data for multiple applications with one system

Mass Spectrometry Advantages for Therapeutic ■ If you have the right data security in your laboratory Drug Monitoring: A Close Look at Teicoplanin Guest Speaker: Brian Keevil, Professor at University Our Clinical Specialists look forward to meeting you: Hospital of South Manchester, UK

Date: Wednesday, September 25 Time: 13:30 to 14:15 Location: Paracelsus Meeting Room

Space is limited. Be sure to sign up at at our Stefanie Peter Simone Welcome Desk. Wernisch Batjoens Donzelli Germany Benelux, Switzerland France, Italy, Spain, and Portugal

Collect your multipurpose buff that is SCIENTIFIC POSTERS as flexible as our workflow solutions Wednesday, September 25 | Exhibit Hall which are adaptable to your needs! 15:30 • #27F: Rapid UPLC-MS/MS Dried Blood Spot Analysis of Steroid Hormones Waters Booth 12 & 13 for Clinical Research, Dominic Foley 15:30 • #3B: Simultaneous Determination of Vitamins B1, B2 and B6 in Whole Blood by LC-MSMS, Stefanie Wernisch

Thursday September 26 | Exhibit Hall 09:30 • #28G: Reversed-phase UPLC-MS/MS Analysis of Plasma Catecholamines and Metanephrines for Clinical Research, Gareth Hammond

ORAL PRESENTATION "Clinical diagnostics is more than collecting Thursday, September 26 | Trakl Hall data. It's making a difference in someone's 13:35: MS Imaging: Method Development Session life. When you analyze samples, you High-Throughput Automated Tissue Imaging by DESI-MS, Three-Dimensional transform data into better care. Because Tissue Imaging or Large Sample Cohort Mapping, Emrys Jones every piece of information is a part of an explanation, and every sample is a life." THE WATERS TEAM

▶▷ Learn more at www.waters.com/clinical

Rookie of the year Small size. Massive impact.

The MALDI-8020 is the newcomer in the Shimadzu Multi-talent system family of MALDI products. This linear MALDI-TOF for analysis of proteins, peptides, polymers and other mass spectrometer combines talents and skills such analytes as outstanding speed, accuracy and performance. It targets researchers developing MALDI-based diag- Additional ‘Rookie of the year’ talents nostic methods as well as labs where quality control such as TrueClean automated cleaning source, methods or rapid screening of intact samples are barcode reader and MALDI Solutions software for routine. Pharma quality control labs

Small size due to benchtop design with a compact footprint

Massive impact through performance similar to larger, more expensive devices

www.shimadzu.eu/rookie-of-the-year