January 26, 2016 u vol. 113 u no. 4

From the Cover

838 Environmental consequences of megafaunal extinction E440 Deleterious mutations in human populations 931 Population growth and agriculture 1080 Vetoing self-initiated movements

Contents

THIS WEEK IN PNAS 799 In This Issue Cover image: Pictured is a Columbian mammoth, which existed in North PNAS 100TH ANNIVERSARY ARTICLE America until 11,000 years ago. The Columbian mammoth is one of over 100 PERSPECTIVE large herbivores and carnivores that 801 Discovery of RNA splicing and genes in pieces went extinct as modern humans spread Arnold J. Berk around the world. Large animals are See companion article on page 3171 in issue 8 of volume 74 particularly important in shaping the structure and function of . Yadvinder Malhi et al. introduce LETTERS (ONLINE ONLY) the and E407 Advance of plant species on slopes of the Chimborazo volcano (Ecuador) Function: From the Pleistocene to the calculated based on unreliable data Special Feature, Petr Sklena´r appearing in this issue, which explores  the environmental consequences of past E409 Reply to Sklenár: Upward vegetation shifts on Chimborazo are robust and contemporary megafaunal decline Naia Morueta-Holme, Kristine Engemann, Pablo Sandoval-Acun˜a, Jeremy D. Jonas, R. Max Segnitz, and Jens-Christian Svenning as well as the roles played by megafauna in the restoration of ecosystems. See the E411 Phylogenetic uncertainty and fossil calibration of Asteraceae chronograms Perspective by Malhi et al. on pages Jose L. Panero 838–846. Image courtesy of Carl Buell, E412 Reply to Panero: Robust phylogenetic placement of fossil pollen grains: The case with the original on display at The of Asteraceae Mammoth Site, Hot Springs, South Dakota. Viviana D. Barreda, Luis Palazzesi, Maria C. Tellerı´a, Eduardo B. Olivero, J. Ian Raine, and Fe´lix Forest

CORE CONCEPTS—A brief introduction to emerging topics in 806 Rewilding John Carey

COMMENTARIES 809 Patterns of deleterious variation between human populations reveal an unbalanced load Rajiv C. McCoy and Joshua M. Akey See companion article on page E440 812 Prehistoric hunter–gatherer population growth rates rival those of agriculturalists Robert L. Bettinger See companion article on page 931

Free online through the PNAS open access option. PNAS u January 26, 2016 u vol. 113 u no. 4 u iii–vii Downloaded by guest on October 1, 2021 815 Sweet beginning for cancer stem cells 868 Global nutrient transport in a world of giants Linda G. Baum Christopher E. Doughty, Joe Roman, Søren Faurby, Adam Wolf, See companion article on page 960 Alifa Haque, Elisabeth S. Bakker, Yadvinder Malhi, John B. Dunning Jr., and Jens-Christian Svenning 817 Reckoning the moment of reckoning in spontaneous voluntary movement 874 Exploring the influence of ancient and historic Sebo Uithol and Aaron Schurger megaherbivore extirpations on the global methane budget See companion article on page 1080 Felisa A. Smith, John I. Hammond, Meghan A. Balk, Scott M. Elliott, S. Kathleen Lyons, Melissa I. Pardi, Catalina P. Tome´, Peter J. Wagner, and Marie L. Westover PNAS PLUS 880 Sea otters, kelp forests, and the extinction of Steller’s 820 Significance Statements sea cow Brief statements written by the authors about the significance of their James A. Estes, Alexander Burdin, and Daniel F. Doak papers. 886 Test of Martin’s overkill hypothesis using radiocarbon dates on extinct megafauna INAUGURAL ARTICLES Todd A. Surovell, Spencer R. Pelton, Richard Anderson-Sprecher, and Adam D. Myers 822 Structural foundations of optogenetics: Determinants 892 Dispersal limitation induces long-term biomass of channelrhodopsin ion selectivity collapse in overhunted Amazonian forests Andre Berndt, Soo Yeun Lee, Jonas Wietek, Charu Carlos A. Peres, Thaise Emilio, Juliana Schietti, Sylvain J. M. Ramakrishnan, Elizabeth E. Steinberg, Asim J. Rashid, Hoseok Desmoulie`re, and Taal Levi Kim, Sungmo Park, Adam Santoro, Paul W. Frankland, Shrivats M. Iyer, Sally Pak, Sofie A¨hrlund-Richter, Scott L. Delp, Robert C. Malenka, Sheena A. Josselyn, Marie Carle´n, Peter Hegemann, and Karl Deisseroth PHYSICAL SCIENCES 830 APOL1 kidney disease risk variants cause cytotoxicity ASTRONOMY by depleting cellular potassium and inducing 907 Origin of the p-process radionuclides 92Nb and 146Sm stress-activated protein kinases in the early solar system and inferences on the birth Opeyemi A. Olabisi, Jia-Yue Zhang, Lynn VerPlank, Nathan of the Sun Zahler, Salvatore DiBartolo III, John F. Heneghan, Johannes S. Maria Lugaro, Marco Pignatari, Ulrich Ott, Kai Zuber, Claudia Schlo¨ndorff, Jung Hee Suh, Paul Yan, Seth L. Alper, David J. Travaglio, Gyo¨rgy Gyu¨rky, and Zsolt Fu¨lo¨p Friedman, and Martin R. Pollak

CHEMISTRY MEGAFAUNA AND ECOSYSTEM FUNCTION: FROM E413 Close relation between quantum interference in THE PLEISTOCENE TO THE ANTHROPOCENE molecular conductance and diradical existence SPECIAL FEATURE Yuta Tsuji, Roald Hoffmann, Mikkel Strange, and Gemma C. Solomon PERSPECTIVES 838 Megafauna and ecosystem function from the COMPUTER SCIENCES Pleistocene to the Anthropocene 913 Private algorithms for the protected in social Yadvinder Malhi, Christopher E. Doughty, Mauro Galetti, network search Felisa A. Smith, Jens-Christian Svenning, Michael Kearns, Aaron Roth, Zhiwei Steven Wu, and John W. Terborgh and Grigory Yaroslavtsev 847 Combining paleo-data and modern exclosure experiments to assess the impact of megafauna EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES extinctions on woody vegetation 856 Variable impact of late-Quaternary megafaunal Elisabeth S. Bakker, Jacquelyn L. Gill, Christopher N. Johnson, extinction in causing ecological state shifts Frans W. M. Vera, Christopher J. Sandom, Gregory P. Asner, in North and South America and Jens-Christian Svenning Anthony D. Barnosky, Emily L. Lindsey, Natalia A. Villavicencio, 898 Science for a wilder Anthropocene: Synthesis and Enrique Bostelmann, Elizabeth A. Hadly, James Wanket, future directions for trophic rewilding research and Charles R. Marshall Jens-Christian Svenning, Pil B. M. Pedersen, C. Josh Donlan, 874 Exploring the influence of ancient and historic Rasmus Ejrnæs, Søren Faurby, Mauro Galetti, Dennis M. megaherbivore extirpations on the global Hansen, Brody Sandel, Christopher J. Sandom, John W. methane budget Terborgh, and Frans W. M. Vera Felisa A. Smith, John I. Hammond, Meghan A. Balk, Scott M. Elliott, S. Kathleen Lyons, Melissa I. Pardi, Catalina P. Tome´, RESEARCH ARTICLES Peter J. Wagner, and Marie L. Westover 856 Variable impact of late-Quaternary megafaunal 919 Pedothem carbonates reveal anomalous North American extinction in causing ecological state shifts atmospheric circulation 70,000–55,000 years ago in North and South America Erik J. Oerter, Warren D. Sharp, Jessica L. Oster, Angela Anthony D. Barnosky, Emily L. Lindsey, Natalia A. Villavicencio, Ebeling, John W. Valley, Reinhard Kozdon, Ian J. Orland, John Enrique Bostelmann, Elizabeth A. Hadly, James Wanket, Hellstrom, Jon D. Woodhead, Janet M. Hergt, Oliver A. and Charles R. Marshall Chadwick, and Ronald Amundson 862 The impact of large terrestrial carnivores on 925 Marine biogenic source of atmospheric organic Pleistocene ecosystems nitrogen in the subtropical North Atlantic Blaire Van Valkenburgh, Matthew W. Hayward, William J. Katye E. Altieri, Sarah E. Fawcett, Andrew J. Peters, Daniel M. Ripple, Carlo Meloro, and V. Louise Roth Sigman, and Meredith G. Hastings

iv u www.pnas.org Contents Downloaded by guest on October 1, 2021 ENVIRONMENTAL SCIENCES 972 A dynamic Asp–Arg interaction is essential for 1008 Neotropical forest expansion during the last glacial catalysis in microsomal prostaglandin E2 synthase period challenges refuge hypothesis Joseph S. Brock, Mats Hamberg, Navisraj Balagunaseelan, Yuri L. R. Leite, Leonora P. Costa, Ana Carolina Loss, Rita G. Michael Goodman, Ralf Morgenstern, Emilia Strandback, Bengt Rocha, Henrique Batalha-Filho, Alex C. Bastos, Vale´ria S. Samuelsson, Agnes Rinaldo-Matthis, and Jesper Z. Haeggstro¨m Quaresma, Vale´ria Fagundes, Roberta Paresque, Marcelo 978 Molecular mechanism of viomycin inhibition of peptide Passamani, and Renata Pardini elongation in bacteria Mikael Holm, Anneli Borg, Ma˚ns Ehrenberg, and Suparna Sanyal SOCIAL SCIENCES BIOPHYSICS AND COMPUTATIONAL BIOLOGY ANTHROPOLOGY 822 Structural foundations of optogenetics: Determinants ’ 886 Test of Martin s overkill hypothesis using radiocarbon of channelrhodopsin ion selectivity dates on extinct megafauna Andre Berndt, Soo Yeun Lee, Jonas Wietek, Charu Todd A. Surovell, Spencer R. Pelton, Richard Ramakrishnan, Elizabeth E. Steinberg, Asim J. Rashid, Hoseok Anderson-Sprecher, and Adam D. Myers Kim, Sungmo Park, Adam Santoro, Paul W. Frankland, 931 Agriculture, population growth, and statistical analysis Shrivats M. Iyer, Sally Pak, Sofie A¨hrlund-Richter, Scott L. Delp, of the radiocarbon record Robert C. Malenka, Sheena A. Josselyn, Marie Carle´n, Peter Hegemann, and Karl Deisseroth H. Jabran Zahid, Erick Robinson, and Robert L. Kelly See Commentary on page 812 CELL BIOLOGY PSYCHOLOGICAL AND COGNITIVE SCIENCES 984 Gain-of-function mutations of Ptpn11 (Shp2) cause E420 Attention promotes episodic encoding by stabilizing aberrant mitosis and increase susceptibility to hippocampal representations DNA damage-induced malignancies Mariam Aly and Nicholas B. Turk-Browne Xia Liu, Hong Zheng, Xiaobo Li, Siying Wang, Howard J. Meyerson, Wentian Yang, Benjamin G. Neel, and Cheng-Kui Qu 936 Intuition, deliberation, and the evolution of cooperation Adam Bear and David G. Rand 990 Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion 942 Endogenous sources of variation in Nan-Peng Chen, Borhan Uddin, Renate Voit, language acquisition and Elmar Schiebel Chung-hye Han, Julien Musolino, and Jeffrey Lidz 996 Developmental accumulation of inorganic 948 Covert digital manipulation of vocal emotion alter polyphosphate affects germination and energetic Dictyostelium discoideum speakers’ emotional states in a congruent direction metabolism in Jean-Julien Aucouturier, Petter Johansson, Lars Hall, Rodrigo Thomas Miles Livermore, Jonathan Robert Chubb, Segnini, Lolita Mercadie´, and Katsumi Watanabe and Adolfo Saiardi

SOCIAL SCIENCES DEVELOPMENTAL BIOLOGY 913 Private algorithms for the protected in social 1002 Quantitative proteomics identify DAB2 as a cardiac network search developmental regulator that inhibits β Michael Kearns, Aaron Roth, Zhiwei Steven Wu, WNT/ -catenin signaling and Grigory Yaroslavtsev Peter Hofsteen, Aaron M. Robitaille, Daniel Patrick Chapman, Randall T. Moon, and Charles E. Murry 954 Hiding personal information reveals the worst Leslie K. John, Kate Barasz, and Michael I. Norton 856 Variable impact of late-Quaternary megafaunal BIOLOGICAL SCIENCES extinction in causing ecological state shifts BIOCHEMISTRY in North and South America Anthony D. Barnosky, Emily L. Lindsey, Natalia A. Villavicencio, E430 Identification of a mammalian glycerol-3-phosphate Enrique Bostelmann, Elizabeth A. Hadly, James Wanket, phosphatase: Role in metabolism and signaling in and Charles R. Marshall pancreatic β-cells and hepatocytes Yves Mugabo, Shangang Zhao, Annegrit Seifried, Sari Gezzar, 868 Global nutrient transport in a world of giants Anfal Al-Mass, Dongwei Zhang, Julien Lamontagne, Camille Christopher E. Doughty, Joe Roman, Søren Faurby, Adam Wolf, Attane, Pegah Poursharifi, Jose´ Iglesias, Erik Joly, Marie-Line Alifa Haque, Elisabeth S. Bakker, Yadvinder Malhi, John B. Peyot, Antje Gohla, S. R. Murthy Madiraju, and Marc Prentki Dunning Jr., and Jens-Christian Svenning 960 Stage-specific embryonic antigen-3 (SSEA-3) and 874 Exploring the influence of ancient and historic β3GalT5 are cancer specific and significant megaherbivore extirpations on the global markers for breast cancer stem cells methane budget Sarah K. C. Cheung, Po-Kai Chuang, Han-Wen Huang, Felisa A. Smith, John I. Hammond, Meghan A. Balk, Scott M. Wendy W. Hwang-Verslues, Candy Hsin-Hua Cho, Wen-Bin Elliott, S. Kathleen Lyons, Melissa I. Pardi, Catalina P. Tome´, Yang, Chia-Ning Shen, Michael Hsiao, Tsui-Ling Hsu, Chuan-Fa Peter J. Wagner, and Marie L. Westover Chang, and Chi-Huey Wong 880 Sea otters, kelp forests, and the extinction of Steller’s See Commentary on page 815 sea cow 966 Intermediates in the assembly of mitotic checkpoint James A. Estes, Alexander Burdin, and Daniel F. Doak complexes and their role in the regulation of the 892 Dispersal limitation induces long-term biomass anaphase-promoting complex collapse in overhunted Amazonian forests Sharon Kaisari, Danielle Sitry-Shevah, Shirly Miniowitz-Shemtov, Carlos A. Peres, Thaise Emilio, Juliana Schietti, Sylvain J. M. and Avram Hershko Desmoulie`re, and Taal Levi

Contents PNAS u January 26, 2016 u vol. 113 u no. 4 u v Downloaded by guest on October 1, 2021 ENVIRONMENTAL SCIENCES MEDICAL SCIENCES 1008 Neotropical forest expansion during the last glacial E450 Versatile strategy for controlling the specificity and period challenges refuge hypothesis activity of engineered T cells Yuri L. R. Leite, Leonora P. Costa, Ana Carolina Loss, Rita G. Jennifer S. Y. Ma, Ji Young Kim, Stephanie A. Kazane, Rocha, Henrique Batalha-Filho, Alex C. Bastos, Vale´ria S. Sei-hyun Choi, Hwa Young Yun, Min Soo Kim, David T. Quaresma, Vale´ria Fagundes, Roberta Paresque, Marcelo Rodgers, Holly M. Pugh, Oded Singer, Sophie B. Sun, Passamani, and Renata Pardini Bryan R. Fonslow, James N. Kochenderfer, Timothy M. Wright, Peter G. Schultz, Travis S. Young, Chan Hyuk Kim, and Yu Cao EVOLUTION E440 Distance from sub-Saharan Africa predicts mutational E459 Switch-mediated activation and retargeting of CAR-T load in diverse human genomes cells for B-cell malignancies David T. Rodgers, Magdalena Mazagova, Eric N. Hampton, Brenna M. Henn, Laura R. Botigue´, Stephan Peischl, Yu Cao, Nitya S. Ramadoss, Ian R. Hardy, Andrew Schulman, Isabelle Dupanloup, Mikhail Lipatov, Brian K. Maples, Juanjuan Du, Feng Wang, Oded Singer, Jennifer Ma, Alicia R. Martin, Shaila Musharoff, Howard Cann, Vanessa Nunez, Jiayin Shen, Ashley K. Woods, Timothy M. Michael P. Snyder, Laurent Excoffier, Jeffrey M. Kidd, Wright, Peter G. Schultz, Chan Hyuk Kim, and Carlos D. Bustamante and Travis S. Young See Commentary on page 809 830 APOL1 kidney disease risk variants cause cytotoxicity 862 The impact of large terrestrial carnivores on by depleting cellular potassium and inducing Pleistocene ecosystems stress-activated protein kinases Blaire Van Valkenburgh, Matthew W. Hayward, William J. Opeyemi A. Olabisi, Jia-Yue Zhang, Lynn VerPlank, Nathan Ripple, Carlo Meloro, and V. Louise Roth Zahler, Salvatore DiBartolo III, John F. Heneghan, Johannes S. 936 Intuition, deliberation, and the evolution of cooperation Schlo¨ndorff, Jung Hee Suh, Paul Yan, Seth L. Alper, David J. Adam Bear and David G. Rand Friedman, and Martin R. Pollak 1050 Stochastic modeling reveals an evolutionary 1014 Decanalization of wing development accompanied the Drosophila mechanism underlying elevated rates of evolution of large wings in high-altitude childhood leukemia Justin B. Lack, Matthew J. Monette, Evan J. Johanning, Andrii I. Rozhok, Jennifer L. Salstrom, Quentin D. Sprengelmeyer, and John E. Pool and James DeGregori

GENETICS E440 Distance from sub-Saharan Africa predicts mutational MICROBIOLOGY load in diverse human genomes 1056 Structure and stabilization of the Hendra virus F Brenna M. Henn, Laura R. Botigue´, Stephan Peischl, glycoprotein in its prefusion form Isabelle Dupanloup, Mikhail Lipatov, Brian K. Maples, Joyce J. W. Wong, Reay G. Paterson, Robert A. Lamb, Alicia R. Martin, Shaila Musharoff, Howard Cann, and Theodore S. Jardetzky Michael P. Snyder, Laurent Excoffier, Jeffrey M. Kidd, and Carlos D. Bustamante See Commentary on page 809 NEUROSCIENCE 1020 Testing the kinship theory of intragenomic conflict in E420 Attention promotes episodic encoding by stabilizing honey bees (Apis mellifera) hippocampal representations Mariam Aly and Nicholas B. Turk-Browne David A. Galbraith, Sarah D. Kocher, Tom Glenn, Istvan Albert, Greg J. Hunt, Joan E. Strassmann, David C. Queller, E469 Transcriptional profiles of supragranular-enriched and Christina M. Grozinger genes associate with corticocortical network architecture in the human brain IMMUNOLOGY AND INFLAMMATION Fenna M. Krienen, B. T. Thomas Yeo, Tian Ge, Randy L. Buckner, and Chet C. Sherwood 1026 Prolongevity hormone FGF21 protects against immune senescence by delaying age-related E479 Neuregulin1 displayed on motor axons regulates thymic involution terminal Schwann cell-mediated synapse elimination Yun-Hee Youm, Tamas L. Horvath, David J. Mangelsdorf, at developing neuromuscular junctions Steven A. Kliewer, and Vishwa Deep Dixit Young il Lee, Yue Li, Michelle Mikesh, Ian Smith, Klaus-Armin Nave, Markus H. Schwab, 1032 Nuclear TRAF3 is a negative regulator of CREB and Wesley J. Thompson in B cells 2+ Nurbek Mambetsariev, Wai W. Lin, Laura L. Stunz, 1062 Calcium sensor regulation of the CaV2.1 Ca channel Brett M. Hanson, Joanne M. Hildebrand, contributes to short-term synaptic plasticity in and Gail A. Bishop hippocampal neurons 1038 Structural basis of collagen recognition by human Evanthia Nanou, Jane M. Sullivan, Todd Scheuer, and William A. Catterall osteoclast-associated receptor and design of osteoclastogenesis inhibitors 1068 Altered short-term synaptic plasticity and reduced Joel Haywood, Jianxun Qi, Chun-Chi Chen, muscle strength in mice with impaired regulation 2+ Guangwen Lu, Yingxia Liu, Jinghua Yan, Yi Shi, of presynaptic CaV2.1 Ca channels and George F. Gao Evanthia Nanou, Jin Yan, Nicholas P. Whitehead, Min Jeong 1044 Imaging of the cross-presenting dendritic cell subsets Kim, Stanley C. Froehner, Todd Scheuer, and William A. Catterall in the skin-draining lymph node Masahiro Kitano, Chihiro Yamazaki, Akiko Takumi, Takashi 1074 Purinergic receptor P2RY12-dependent microglial Ikeno, Hiroaki Hemmi, Noriko Takahashi, Kanako Shimizu, closure of the injured blood–brain barrier Scott E. Fraser, Katsuaki Hoshino, Tsuneyasu Kaisho, Nanhong Lou, Takahiro Takano, Yong Pei, Anna L. Xavier, and Takaharu Okada Steven A. Goldman, and Maiken Nedergaard

vi u www.pnas.org Contents Downloaded by guest on October 1, 2021 1080 The point of no return in vetoing CORRECTIONS (ONLINE ONLY) self-initiated movements Matthias Schultze-Kraft, Daniel Birman, Marco Rusconi, AGRICULTURAL SCIENCES Carsten Allefeld, Kai Go¨rgen, Sven Da¨hne, Benjamin Blankertz, and John-Dylan Haynes E488 Honey constituents up-regulate detoxification and immunity genes in the western honey bee Apis mellifera See Commentary on page 817 Wenfu Mao, Mary A. Schuler, and May R. Berenbaum

PHARMACOLOGY APPLIED BIOLOGICAL SCIENCES 1086 Diacylglycerol lipase disinhibits VTA dopamine E489 Genome sequence of the Asian Tiger mosquito, Aedes neurons during chronic nicotine exposure albopictus, reveals insights into its biology, Matthew W. Buczynski, Melissa A. Herman, Ku-Lung Hsu, genetics, and evolution Luis A. Natividad, Cristina Irimia, Ilham Y. Polis, Xiao-Guang Chen, Xuanting Jiang, Jinbao Gu, Meng Xu, Yang Wu, Holly Pugh, Jae Won Chang, Micah J. Niphakis, Yuhua Deng, Chi Zhang, Mariangela Bonizzoni, Wannes Dermauw, Benjamin F. Cravatt, Marisa Roberto, John Vontas, Peter Armbruster, Xin Huang, Yulan Yang, Hao Zhang, and Loren H. Parsons Weiming He, Hongjuan Peng, Yongfeng Liu, Kun Wu, Jiahua Chen, 1092 Critical roles of Gi/o proteins and phospholipase C-δ1 Manolis Lirakis, Pantelis Topalis, Thomas Van Leeuwen, Andrew in the activation of receptor-operated Brantley Hall, Xiaofang Jiang, Chevon Thorpe, Rachel Lockridge TRPC4 channels Mueller, Cheng Sun, Robert Michael Waterhouse, Guiyun Yan, Zhijian Jake Tu, Xiaodong Fang, and Anthony A. James Dhananjay P. Thakur, Jin-bin Tian, Jaepyo Jeon, Jian Xiong, Yu Huang, Veit Flockerzi, and Michael X. Zhu SI CORRECTIONS (ONLINE ONLY) POPULATION BIOLOGY BIOCHEMISTRY 886 Test of Martin’s overkill hypothesis using radiocarbon dates on extinct megafauna E490 RNA design rules from a massive open laboratory Todd A. Surovell, Spencer R. Pelton, Richard Jeehyung Lee, Wipapat Kladwang, Minjae Lee, Daniel Cantu, Anderson-Sprecher, and Adam D. Myers Martin Azizyan, Hanjoo Kim, Alex Limpaecher, Snehal Gaikwad, Sungroh Yoon, Adrien Treuille, Rhiju Das, and EteRNA Participants

PSYCHOLOGICAL AND COGNITIVE SCIENCES ENVIRONMENTAL SCIENCES 1098 Discontinuity in the genetic and environmental causes E491 Threat of plastic pollution to seabirds is global, of the intellectual disability spectrum pervasive, and increasing Abraham Reichenberg, Martin Cederlo¨f, Andrew McMillan, Chris Wilcox, Erik Van Sebille, and Britta Denise Hardesty Maciej Trzaskowski, Ori Kapara, Eyal Fruchter, Karen Ginat, Michael Davidson, Mark Weiser, Henrik Larsson, Robert Plomin, and Paul Lichtenstein ix Subscription Form

Contents PNAS u January 26, 2016 u vol. 113 u no. 4 u vii Downloaded by guest on October 1, 2021