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The Breast the Digestive Tract

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The Breast the Digestive Tract The abstracts which follow have been classifled for the convenience of the reader under the following headings : Experimental and Biochemical Studiee, Intrathoraeio Tumors Spontaneous Animal Tumors, Plant The Digestive Tract Tumors, Biological Effeota of Radia- The Liver and Biliary Tract tion The Pancreas Etiology, Clinical Observations, Blood Peritoneal and Retroperitoneal Tumors, Studies Mesenteria Cysts Diagnosis and Treatment The Spleen Tumors of the Skin The Suprarenal Glands The Eye The Female Genital Traot The Ear The Qenito-Urinary System The Oral Cavity, Nose and Paranasal The Nervous System Sinuses, Throat and Salivary Glands The Bones and Joints The Thyroid and Parathyroid Glands The Lymphatic System The Carotid Body Statbtias, Cancer Research, Education, The Breast Public Health As with any such scheme of classifloation, overlapping has been unavoidable. Shall an article on '' Cutaneous Melanoma, an Histological Study JJ be grouped with the artioles on Histology or with the Skin Tumorsl Shall Traumatia Cerebral Tu- mors go under Trauma or The Nervous System? The reader's ohoice is likely to depend upon his personal interests; an editor may be governed by no such con- siderations. The attempt has been made, therefore, to put such articles in the group where they would seem most likely to be sought by the greatest number. It is hoped that this aim has not been entirely missed. As abstractors are never perfect, and as the opinions expreesed may on occasion seem to an author not to represent adequately his position, opportunity is offered any such to submit his own views for publication. The JOUBNAL will not only welcome conwpondence of this nature but hopes in the future to have a large num- ber of author abstracts, so that the writer of a paper may preeent his subject in his own way. ABSTRACTS EXPERIMENTAL AND BIOCHEMICAL STUDIES, SPONTANEOUS ANIMAL TUMORS, PLANT TUMORS, BIOLOGICAL EFFECTS OF RADIATION Experimental Obmrvations on Tar Tumors, U. CASTBLFRANCO.Oeeervasioni aperimentali sui tumori da oatrame, Riv. di pat. sper. 8: 140-157, 1932. The author applied tar to the skin of 60 mice and 2 hem, giving sixty treatments each over a period of six month. The skin of one set of animals was soarified before the tar was used. In no OBBB did tumors develop. Using 16 rabbits, he injeoted tar dissolved in oil into the breast or sorotum, and in some oases pencilled the rabbits’ ears with oarbon used as one pole of an electria oircuit. Hyperkera- toah resulted, but no real neoplsetio process was found on hiatologio examination. Thia artiole contains photograph and a long bibliography. JEANNEITXIMUNRO Muonce of Breatbing Carbon Monoxide and Oxygen at High Percentages for Prolonged Period8 upon the Development of Tar Cancer in Mice, J. A. CAMP- BBLL. J. Path. & Bact. 36: 243-248,1933. In earlier work (ibid. 35: 379, 1932, abst. in Am. J. Cancer 16: abet. p. 1258, 1932) the author found that oarboa monoxide respiration had a retarding effeot on the growth rate of mow oaroinoma 63, while it had no apparent effeot on that of the Roue fowl swooma. It appeared interesting, in view of the reoent theoretio explanation that the apparent inorease in the inoidenoe of human lung oancer is eaeooiated with the inoreaeed presenoe of oarbon monoxide in the air of streets, garages, faotories, kitohem, etc., to experiment with tar oancer, which more closely ~wemblesspontaneous human oardnoma than do transplantable tumors. The author tarred mice, one series of whioh breathed carbon monoxide, the seoond ordinary air as controls, and the third a gas mixture oontaining about 60 per cent oxygen. The experiments were continued for nine months. The findings are set out in four tables and two graphs. The author’s oonolueions are that oarbon monoxide breathed by doe for pro- longed periods (up to about one third of their span of life) retards but does not prevent the development of tar cancer, and th8t breathing oxygen at 60 per cent of an atmosphere has no effeot on suah development. F. CAVHRS Some Aspects of the Thymus in Mice Treated with Tar and in Mice with Tumors, A. LAMMA. Aspetti diversi del timo in topi inoatramati e in topi portatori di tUmOi, EV. di pat. 8p. 8: 50-67, 1932. The author applied tar at repeated intervals to the shaved skin of 16 miae. Eleven of the animals died in a oaohectio condition during the treatment. These mice all showed aonsiderable atrophy of the thymus. The other animals, whioh did not have cachexia, were killed after a longer aourse of treatment. These showed little atrophy of the thymus. The thymic struoture appeared the same in those animals in which oancer developed under the tar treatment as in those dying at a similar stage of the treatment without oancer. In two of the animals treated primary tumors of the thymus developed, miorosoopio drawings of which illustrate the article. In a seoond experiment the author injected 13 mioe with material from the adenocuucinoma of Ehrlioh. All developed tumors. Twelve of the animals 893 394 ABSTBACTS showed moderate atrophy of the thymus, apparently independent of the duration of the experiment, of the amount of tumor development, and of the general oondi- tion of the animal. The artide contains a review of the literature on the relation of the ductless glands to tumor development. The author accepts the theory of Fiohera that tumor development depends on an imbalanoe of the internal aeoretions and be- lieves that the thymus exerts an inhibitory aotion on tumor development. JEANNIITTIIMUNRO Atypical Epithelial Growth Following the Intrabmnchirl Application of Cod Tar. L. M. SCHABAD.Experimentelle stypisohe Epithelwuoberungen nach intra- traoheobronohialer EinfUhrung dee Steinkohlenteem in die Lungen, Zteohr. f. Krebsforsoh. 38: 154-177, 1932. Two-tenths of a oubio oentimeter of warm ooal tar introduoed onoe into the lunge of 27 guinea-pige, from a syringe inserted into the traohea, did not produoe tumors, although 7 of the animale survived for aiX months or more, and one for fourteen months. Characterhtio inflammatory and regenerative ohanges were set up, somewhat resembling adenoma or even adenoaaroinoma,, and it waa such as these, no doubt, that led previous investigators to desoribe the produotion of oaroinoma. In no om, however, did the lesions grow invaaively or metasta- size, and in animals that lived more than six months it waa evident that they were regressing. WY. H. WOQLOM Combined Action of Roentgen Rap and Tar on the SLln of the white Mmm, G. A. SBDOINID~.Die kombinierte Wirkung der Rhtgenetrahlen und des Steinkohlenteera auf die Haut der weissen Miturn, Ztaohr. f. ICrebeforach. 38: 21-34, 1932. Nineteen mioe were exposed to x-rays, 19 were rayed and later tarred, while 29 were tarred and then rayed. In all 3 series the dose waa 258s to 2840 r, ad- ministered onoe a month, for from two to five months, over an area of 1 sq. om. at the root of the tail, the rest of the body being proteoted meanwhile with 3 mm. sheet lead. The factors were 60 kilovolte, 2 milliamperes, dietanae 28 om., no filter. Suoh exposures produced a ohronio dermatitis and, in one of 11 survivors, a caroinoma, at least 14,200 r having been required in the latter instance. In the seoond group, rayed and then tarred for six months, only one mouse among the 19 surviving developed a aaroinoma. In the third, three months of tarring alone did not suffioe to elicit oaroinoma, though the skin was altered in suoh a way that 6 out of 9 sufvivors reoeiving 16,OOO r developed oanoer. Four mioe that were given 9OOOr all esoaped a malignant growth, but one among 4 that had 6000 r finally fell victim to carcinoma. With this single exception, 15,000 t seemed to be the minimal oardnogenio dose. Au the animals with neoplasms outlived the period ordindy permitted to mioe bearing tar tumors, for the hydine ohanges set up in the oonneotive tissue prevented invaaive growth. [Seven poor photomiorographs leave the reader in doubt, but on the whole the abstraotor is not oonvinced that the lesions were malignant.] WY. H. WOOLOM Mobilization of the Hiotoblastic Reaction in the Suppreedon of Cucinoxq F, VAN~Kuber die Mobilisierung von hietoplaetisoher Reaktion sur Ditmp- fung des Carcinoms, Ztsohr. f. Krebdoraoh. 38: 94-98, 1932. Believing that diminished funotion of the liver and the retiouloendothelial system underlies the development and growth of oancer, the author sought to stimulate these organa in a patient with extensive oanoer of the cheek by introduo- EXPERIMENTAL AND BIOUHlDMICAL STUDIES 395 ing radium emanation subcutaneously in the hepatic region. The result was encouraging, though the patient died. Five rabbits were accordingly injected at the same site with emanation, 4 doses, each of 1/50 millicurie in 0.2 C.C. of physiological saline solution, being given. A few days after the last treatment them animals and five untreated controls were started upon a course of tar painting. Keratosis and cachexia were more advanced in the controls than in the treated group at the end of four months, though no carcinomas developed in either. Attempts to arrest inoperable carcinoma of the stomach in man by setting up a lymphatic and hietiocyte reaction with radium emanation, injected into the leg, are briefly mentioned. WM. H. WOOLOM Period During Which a Transplantable Mouse Sarcoma Can Be Transmitted by Mom of Blood and Tumor-Free Organs, LUDWIKGROSS. uber die Zeitgren- sen der Ubertragungsfehigkeit eines Impfsarkoms mittels des Blutes und der tumorfreien Organe der Maus, Ztschr. f. Krebsforsch. 38: 241-248, 1932. Recent descriptions of the transplantation of various tumors by means of blood or of organs free from metastases suggested to the author the presence of an in- tangible causative agent, though there still remains the difficulty of explaining why transfer should 80 rarely succeed.
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