Life Sciences in Business Capital of Science

Life Sciences in Business

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Index

001 The Amsterdam Metropolitan Area has it all 5

002 The Amsterdam BioMed Cluster for health and wealth 8

003 Scientific spirit, excellence in technology 12

004 Amsterdam life sciences in business 26

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With a multilingual, multicultural, and highly educated work force, the Amsterdam Metropolitan Area excels as a life sciences location. The Amsterdam Metropolitan Area has it all

Good for business, good for living that increases annually. And such a large presence of The City of Amsterdam is known for its open and international businesses brings other benefits. More international character, which attracts people and international companies are choosing to base their organisations from around the world. By maintaining its European operations in the Amsterdam Metropolitan traditional openness to the rest of the world, Amsterdam Area. In 2007, head offices comprised 14 percent of all excels as a business location, offering a competitive new arrivals. Marketing and sales remained the most cost-to-quality ratio, and an outstanding network of important activity among new arrivals (54 percent), professional services designed to assist international followed by representative offices (20 percent). businesses. Amsterdam is the main financial and business Amsterdam also ranks 5th in the list of European region’s centre of the and one of the leading centers for business. in the world. The Amsterdam Metropolitan Area has a strategic location The city has always been a melting pot of cultures. Since in Europe and is centrally situated in Western Europe, the Golden Age of the Dutch East India Company (VOC) which makes the region a central location for business and in the 17th century, Amsterdam has been a hub for world logistics. The region boasts the world’s greatest trade. Today, 174 different nationalities live and work concentration of business and creative service providers together in harmony. The composition and style of the and the region stands out from the crowd as a centre of local working population reflects this: they are international trade. An ever-increasing number of multilingual, multicultural, tolerant, consensus-oriented, international companies are choosing to settle in the and politically and culturally neutral. Amsterdam and its Amsterdam Metropolitan Area because they can better surroundings form a thriving environment in which coordinate their European marketing and distribution business and industry can blossom. activities from here. The region combines transport and The city’s international character makes it a place where logistics expertise with an in-depth knowledge of all the foreign visitors and expatriates feel at home, while the relevant European markets manageable cost of living makes Amsterdam an attractive, affordable (and safe) place to live. Gateway to Europe The Amsterdam Metropolitan Area is a true Gateway Strategic location to Europe. The close proximity to Amsterdam Airport More than 1,400 international companies currently have Schiphol, the presence of good international rail links, and an office in the Amsterdam Metropolitan Area, a number a major seaport, makes the region a major transit hub to

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‘…the favourable location of this region…’

Cees Mens, Senior Director of Operations, MSD BV

Merck Sharp & Dohme (MSD) has been a leader In 1954, MSD was the first European subsidiary of in the field of innovative pharmaceuticals in the American parent company Merck & Co., Inc. Cees Netherlands for 55 years. Since its establishment, Mens: 'The favourable location of this region, close to the Dutch subsidiary has become MSD's largest major ports, an international airport and excellent road production, packaging and distribution centre connections with the rest of the country largely in Europe. The site exports some 100 million determined Merck & Co’s decision to set up business medicines and vaccines for human use to over 140 here. The fact that the Netherlands is regarded as countries worldwide. 'This is one of MSD's most a centre of expertise and know-how in the field of flexible sites worldwide, with constant focus on life sciences reconfirms that this region was a good flexibility in packaging, lean work processes and choice.' continued investment in logistic know-how. This constant focus, with our state-of-the-art production/packaging facility, fits perfectly with this region,’ says Cees Mens.

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and from the 350 million potential customers of the specialists working across Europe, with over 20 percent of European continent. university researchers hailing from outside the Netherlands. And compared to other European capitals, Amsterdam Airport Schiphol offers access to 270 Amsterdam has by far the largest percentage of employees destinations in 92 countries around the world, serviced with higher education: over 40 percent. The Dutch life by 104 different airlines. It is the third largest European sciences sector is knowledge intensive – about 20 percent airport in terms of cargo and the fourth largest European of the workforce is made up of research staff and the airport in terms of passengers. It is situated close to the per-capita R&D output is high. Ports of Amsterdam and Rotterdam and is further Success in Europe depends on employees who know supported by a wide rail and road network. their languages. The Dutch workforce is renowned for its The Amsterdam Port area is the sixth largest seaport in multilingual abilities. The vast majority of Dutch Europe, making it an important international logistics people are fluent in English, which is the primary business intersection. Few other ports are so well situated. Many language in the Netherlands and throughout Europe. international companies that operate their European Furthermore, more than half speak German fluently, while logistics in the Amsterdam Metropolitan Area make use of a quarter speak French. both airport and seaport facilities. With the Amsterdam Internet Exchange (AMS-IX), Service center for expats Amsterdam also boasts the largest Internet hub in the The recently established Expatcenter acts as a one-stop- world, measured both by number of members and by shop service for knowledge migrants and expats arriving traffic. Science parks, knowledge institutes, financial in Amsterdam and . The combined effort centres and data centres all take advantage of this successfully increases the efficiency of services and hypermodern network. simplifies procedures for international companies and their expatriate employees. Multilingual workforce An employer can initiate the registration procedure for an Companies that choose to settle in the Netherlands have employee’s residence permit prior to the new employee’s access to a pool of highly skilled, hardworking, arrival in the country. Expatriates can also visit the center multilingual employees. A model of efficiency, dedication for help on issues such as parking, taxes, healthcare, and flexibility, the Dutch workforce sets the pace for education and many more. Amsterdam’s workforce is well European productivity. In addition to offering a local talent stocked with native speakers from around the globe. pool, the Amsterdam area also attracts many international www.iamsterdam.com/en/living/expatcenter

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‘… partnerships are more important than ever…’

Prof. Dr. Ada M. Kruisbeek Scientific Director, TTO VU & VUmc and Director, Life Sciences Center Amsterdam

‘Global competition is fierce. Just about every state component of the economic growth of this city, and region in the USA has invested heavily in life partnerships between companies and universities sciences as an economic development strategy. and public institutions are more important than ever. Southeast Asia and Eastern Europe and South America follow the trend. It is my wish that this city continues to provide long-term support for connecting all the stakeholders There are several factors that determine the success in this sector: universities and research institutions of life science clusters, but it all begins with and tech transfer offices and small start-up excellence in science, a prolific innovation output, companies. Our job as stakeholders is to convince and strong research universities. We have no public policy makers that their investment will pay shortage of excellence in science in Amsterdam, but off, as it has in many other regions in the world.’ if we want to continue to make that an integral

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In the Amsterdam Metropolitan Area institutes, government, and companies work closely together building an attractive and innovative life sciences industry. The Amsterdam BioMed Cluster for health and wealth

A tradition of scientific excellence diseases and cardiovascular diseases. In addition, The life sciences sector of the Amsterdam Metropolitan considerable activity exists in the field of medical Area is recognised internationally for its strong focus technology. Universities, medical hospitals and research on applied science, which is carried out within institutes are extremely important for the creation of new universities, research institutes, small biotech companies ventures and spin-off companies. Amsterdam BioMed and large pharmaceutical companies. Such a broad range has been created to specifically stimulate knowledge of players is key for an industry so dependent on scientific valorisation: the creation of value from knowledge. breakthroughs for progress. Amsterdam BioMed Cluster The Amsterdam Metropolitan Area has the highest In addition to building a dynamic community to exploit concentration of life sciences research in the Netherlands, synergy between life science organisations in the with a strong biomedical focus, while the majority of life Amsterdam region, the objective of the Amsterdam sciences companies in the area are engaged in some field Biomed Cluster is to open up the regional knowledge and of human health research. technology base to those national and international parties interested in doing business. Its two universities and research institutes together house over 6,700 R&D employees and over 8,000 students in As such it acts as entrance point for (foreign) matchmaking Life Sciences related areas. The total number of life requests and for organisations on fact-finding missions. sciences related and supporting jobs in the sector is The Cluster also develops and coordinates projects that estimated at 20,000, of which 5,000 staff work in highly optimise the preconditions for a healthy and attractive life innovative, R&D intensive companies. sciences industry. This is achieved through the creation of public-private partnerships and well-aimed projects for Amsterdam BioMed combines forces the development of talent, knowledge valorisation, Life Sciences is a priority sector for the Netherlands, and innovation, entrepreneurship, funding, networking, in the Amsterdam Metropolitan Area it receives special international promotion and infrastructure. attention. Amsterdam has the highest concentration of life sciences research in the Netherlands, with scientific The Amsterdam BioMed Cluster is a unifying force in the excellence in five therapeutic and diagnostic areas: region’s life sciences and aims to connect industry and oncology, neurosciences, autoimmunity, infectious knowledge by bringing together entrepreneurs, scientists

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Amsterdam BioMed Cluster

Amsterdam BioMed Cluster

Life Sciences Life Sciences Center Fund Amsterdam Amsterdam

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and related parties. In this effort it works closely together to facilitate the transfer of technology to the private with neighbouring clusters such as Leiden, Rotterdam, sector and to provide emerging technology companies Delft and , as well as with the Dutch innovation and university researchers with vital seed funding and program “Life Sciences & Health”. specialised fi nancial and technical assistance. www.amsterdambiomed.nl www.amsterdambiomed.nl/lsfa

Life Sciences Center Amsterdam Close collaborations In the Life Sciences Center Amsterdam the Technology Amsterdam BioMed is involved in many programs and Transfer Offi ces of the capital’s leading institutions have projects that stimulate the life sciences industry. The joined forces to commercialise their combined life Dutch innovation program “Life Sciences & Health” is sciences research results for the public good. a combined initiative of multiple parties active in the Licensing opportunities, expertise centers, patient health-related life sciences sector in the Netherlands, cohorts, biobanks, facilities and tools from the University and is empowered by the Dutch Ministry of Economic of Amsterdam/Academic Medical Center, the VU Affairs. The nationwide program completes a unique University/VU University medical center, the Sanquin innovation infrastructure that facilitates the entire Blood Supply Foundation, and the Netherlands innovation process from exploratory research to Cancer Institute are combined in the Life Sciences translational research and valorisation. Center Amsterdam. In addition the Center welcomes ImmunoValley is a nation-wide research- and valorisation multinationals as well as small and (international) medium program in emerging infectious diseases connecting sized enterprises in search for knowledge and innovation. animal and human health. www.amsterdambiomed.nl/lsca BioPort Europe provides integrated business services for Indian life sciences companies entering the European Life Sciences Fund Amsterdam Market. The Life Sciences Fund Amsterdam provides investment The health related life sciences sector is already an capital to fund biomedical entrepreneurial activity in the important sector in the Dutch economy, contributing Amsterdam Metropolitan Area. The fund targets 3 percent of the GDP and employing 55,000. In the companies that are developing commercially promising Netherlands, over 900 companies are active in health products and technologies in life sciences, including: related life sciences, with over 400 in the pharmaceuticals, biotechnology, information technology biopharmaceutical industry, and almost 400 in and other high technology opportunities that offer diagnostics. venture capital returns. The close co-operation between www.lifesciences.nl the Fund, the Cluster and the technology transfer offi ces www.immunovalley.nl of the Life Sciences Center Amsterdam, enables the fund www.amsterdambiomed.nl/bpe

Facts & Figures • From the 55,000 life sciences employees in the Netherlands, over 20,000 are employed in the Amsterdam Metropolitan Area. • From the 935 companies active in health-related life sciences, over 300 are located in the Amsterdam Metropolitan Area. • From the 150 companies with an R&D-focused business model, over 70 are located in the Amsterdam Metropolitan Area. 12

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Building on its strong biomedical knowledge base, the life sciences industry is thriving in Amsterdam. Scientific spirit, excellence in technology

A strong scientific heritage tools to accelerate research and business. The institutes Amsterdam has two universities: The University of take part in various public-private partnerships and can be Amsterdam (UvA) and the VU University. Both are contacted for contract research or private cooperation. affiliated with state-of-the-art academic hospitals; The This allows companies to utilise the broad array of facilities UvA with the Academic Medical Center (AMC), while the and equipment available and, as importantly, the VU is affiliated with the VU Medical Center (VUmc). The expertise and knowledge available from the expertise city also has several renowned specialised research centers. institutes, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AvL), the Netherlands Areas of scientific excellence Institute for Neuroscience (NIN) and the Sanquin Blood Supply Foundation. Cardiovascular diseases Cardiovascular diseases are often the result of multiple different factors, and therefore demand a multidisciplinary A tradition of excellence exists in five disease and research orientation. As with cancer and neurosciences, therapeutic areas: cardiovascular diseases, infectious this requires strong interactions between pre-clinical and diseases, neurosciences, oncology, and auto-immune clinical researchers to optimise translation to the clinic. diseases. In addition, considerable activity takes place It also requires links between programmes on metabolic in the field of medical technology. Within these areas of disorders that cause vascular dysfunction (such as excellence, multiple interactions exist between research diabetes and lipid disorders and obesity), and institutes, biotech companies and pharmaceutical programmes on thrombosis and atherosclerosis. companies.The international recognition of Amsterdam’s Innovative cardiovascular imaging platforms support these medical life sciences is illustrated by its large scientific programmes. The expertise of the VUmc and AMC, output, the abundant representation of its scientists in together with knowledge institutes like Sanquin international research programmes and by the many result in highly innovative research programmes with a clinical studies pharmaceutical companies perform here. strong focus on epidemiological studies to fine-tune prevention programmes, and extensive In addition to science and technology, the capital’s databases derived from family studies have been built knowledge institutions offer a portfolio of facilities and up to obtain in-depth knowledge of the inheritability of

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cardiovascular diseases. This knowledge is directly will be available for diagnostic and research purposes. translated into innovative therapeutics and diagnostics. Important companies in the area with a scientific focus on Active companies in the region include Solvay neurosciences are Solvay Pharmaceuticals and Quintiles. Pharmaceuticals and Merck Sharp & Dohme. Oncology Infectious diseases Amsterdam is home to some exceptionally strong Amsterdam has extensive expertise in sexually centres for oncological research and treatment. The VUmc transmitted and tropical infectious diseases and in the through its Cancer Centre Amsterdam (CCA/V-ICI) and the development of means for preventing infection and AMC, have impressive track records in fundamental, optimising the treatments. Its strong multidisciplinary translational and clinical research, and are equipped with approach in virology provides opportunities for the all the necessary cutting-edge technology. development of innovative vaccines and new methods in The Netherlands Cancer Institute (NKI), which is affiliated the fields of transplantation and immunology and bacterial with the Antoni van Leeuwenhoek Hospital, is a worldwide infections. Sanquin and the AMC work together on blood renowned cancer institute, with several research groups transmittable diseases, and the AMC has a strong track focusing on all aspects of oncology. The direct connec- record in the identification of novel viruses. Another main tion to the v AvL-hospital gives access to valuable patient focus of the AMC is its AIDS programme, and the design cohorts and research material. of novel antiretroviral therapies has been the basis for many productive scientific and industry collaborations. Today’s clinical development strategies for cancer are VUmc and the AMC work together on the development geared towards designing patient-tailored therapies, and of rapid high throughput microbiological and it is crucial that fundamental research occurs in a immunogenetic typing and diagnostic systems, to improve translational research setting. Amsterdam’s oncology the prevention and treatment of bacterial and parasitic programmes provide just that, and have built up many diseases. Moreover, the Royal Tropical Institute (KIT) has partnerships with industry in key areas of preclinical and several research departments specialized in infectious clinical development. The Amsterdam region hosts a diseases of tropical origin. Prominent companies based in broad spectrum of companies involved in cancer research or near Amsterdam that are active in the field of infectious like Agendia, AIMM Therapeutics, DC Prime, Kiadis diseases and vaccines include Sanofi Pasteur MSD and Pharma and Kreatech Biotechnology. AIMM Therapeutics. Autoimmune and inflammatory diseases Neurosciences A malfunctioning immune system may lead to all kinds of The scientific and clinical community in Amsterdam has disorders. Conversely, many conditions influence the invested heavily in building the interdisciplinary body’s immune system. Treatments for autoimmune infrastructure best suited for translational research in disease have traditionally been immunosuppressive, neuroscience. Expertise centers like the Netherlands anti-inflammatory, or palliative. Some of these Institute for Neuroscience (NIN) making important immunotherapies may be associated with increased risk of contributions to neurosciences in the region, especially adverse effects, such as susceptibility to infection. with the Netherlands Brain Bank (NBB). The VUmc has its Immunology is an important area of excellent research and own Neuroscience Campus a centre dedicated to Multiple knowledge for Amsterdam. The AMC and Sanquin have a Sclerosis and an Alzheimer Center, who are built on a combined research program with a focus on primary and multidisciplinary approach in order to optimise patient secondary disorders of the defence mechanism, allergy, care, scientific research and education around these rheumatology and autoimmune diseases. The VUmc has a diseases. The Swammerdam Institute for Life dedicated research institute (CCA/V-ICI) working on basal Sciences, affiliated to the UvA also has a well-known and patient-related research on cancer and autoimmune Center of Neuroscience. On the Medical Business Park, disorders. There are also strong relations with other areas the Spinozacenter for Neuroimaging is currently being of excellence, such as oncology and infectious diseases. developed; this new high-tech imaging center has Next to the knowledge institutes, the region has regional support from several knowledge institutes. several well-known and promising companies active in Special high-tech equipment like a 3T and 7T MRI scanner immunology, like Arthrogen and Genzyme.

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Medical technology The VU University Amsterdam is located on Medical technology is rapidly expanding in the a compact urban campus in the southwestern Amsterdam Metropolitan area. The short lines between part of the city. The VU has about 18,000 the consumer market where problems are faced and students, most of whom are full-time. The the research institutes and companies that are able to number employees is about 4,300, and it has solve them, create a favourable environment for the an annual budget of around 487 million. development of medical technologies. The field is The VU is a modern research university supported by the two university medical centers, the interdisciplinary research is actively promoted. research institutes and a large and strong ICT sector, www.vu.nl including prominent companies such as IBM and Cisco. Several innovative companies, like DEAM Corporation, The VU University Medical Center (VUmc) is Finapres Medical Systems and Personal Space the university hospital affiliated with the VU. It Technologies are active in the Medical Technology sector. is one of the Netherlands leading hospitals, as www.amsterdambiomed.nl/participants well as being one of the largest, with a budget of 556 million and over 5,500 employees. The VUmc has intensive cooperation with the AMC, which is beneficial to both hospitals. Tertiary care departments include advanced trauma care, paediatric and neonatal intensive care, cardiothoracic surgery, neurosurgery, infectious diseases and other departments. A medical emergency rescue helicopter is also affiliated Universities and centers with the hospital. of excellence www.vumc.nl

The University of Amsterdam is a The Netherlands Cancer Institute (NKI) comprehensive research university located is the only dedicated cancer center in the in the heart of the city of Amsterdam. With a Netherlands and maintains an important role as budget of 581 million, over 28,000 students a national and international center of scientific and around 5,000 staff, the UvA is one of and clinical expertise, development and Europe’s major universities. raining. The NKI-AvL has about 1,900 www.uva.nl employees and a total budget of around 150 million. The three major areas of research are The Academic Medical Center (AMC) is the fundamental, clinical and translational cancer university hospital affiliated with the University research. The laboratory covers all major areas of Amsterdam. It is one of the largest hospitals of cancer research, with special emphasis on in the Netherlands, and is located in the cell-based screens, important mouse tumour southeastern part of Amsterdam. The AMC models, cell biology, structural biology and has a budget of 643 million and has over 6,000 epidemiology. The institute coordinates and employees. The AMC has an intensive participates in many clinical trials; most of cooperation with Amsterdam’s other university these are phase 1, 2 or 3 studies of potential hospital, the VU University Medical Center, new treatments and several combinations of which is affiliated with the VU University, innovative chemotheraphy, radiotherapy and Amsterdam’s other university. Tertiary care surgery. departments include advanced trauma care, www.nki.nl paediatric and neonatal intensive care, cardiothoracic surgery, neurosurgery, Sanquin Blood Supply Foundation is a large infectious diseases and other departments. not-for-profit foundation with over 2,800 www.amc.nl employees and a budget of 257 million.

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‘…an appealing concentration of experts…’

Prof. Dr. Anton Berns Director of Research and Chairman of the Board of Directors of the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL)

‘Many scientists from abroad and the Netherlands sciences and many of our staff members occupy work in one of the scientific institutions here. chairs at one of the universities. This creates an Together, they constitute an appealing atmosphere in which individuals, disciplines and concentration of experts with a variety of scientific institutions easily interact. skills and cultural backgrounds. There are ample opportunities for them to interact and engage in Post doc and graduate students from abroad and collaborations. the Netherlands alike can take advantage of the low-threshold access to the many scientific experts For instance, the Netherlands Cancer Institute - and facilities in the Amsterdam area. Amsterdam Antoni van Leeuwenhoek Hospital has strong ties is a vibrant home for them, not only providing the with the two universities in Amsterdam. We have environment to meet interesting colleagues coming several joint clinical departments, run the graduate from all over the world, but also a rich cultural scene school in oncology together, participate in the making their life exciting outside the laboratory as education of undergraduate students in life well.’

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Sanquin is responsible for the supply of blood The Netherlands Institute for Neuroscience and blood products, for use in hospitals as well (NIN) is located on the Medical Business Park as for scientific research. Sanquin has an AMC in Amsterdam. The organisation carries extensive research program in the field of out fundamental neuroscience research with cellular blood products, plasma products and special emphasis on the brain and the visual diagnostics, a large part of which is carried out system. The research is focused on by the research division. Sanquin carries out development, plasticity and ageing and it is both strategic and applied research. A broad often linked to clinical research questions. In range of studies in immunology, cell biology, addition, the NIN includes the Netherlands blood-borne infectious diseases, and Brain Bank (NBB). haematology and blood transfusion medicine www.nin.knaw.nl are conducted every year. New fields of research www.brainbank.nl include stem cells and cellular immunotherapy. These studies are conducted in close The Royal Tropical Institute (KIT) in collaboration with academic centres such as the Amsterdam is a not-for-profit organisation with Amsterdam University Medical Center and the a budget of about 41 million and over 400 Leiden University Medical Center, as well as employees worldwide. KIT works for both the non-academic research centers in the public and the private sector in collaboration Netherlands and abroad. Sanquin also performs with partners in the Netherlands and abroad. all blood-related laboratory tests for hospitals, The institute conducts research and provides blood banks, institutes, obstetrics clinics, educational, consultancy and information insurance companies and pharmaceutical services. KIT Biomedical Research is one of the organisations. It has over 600 different branches of the institute and a leader in the diagnostic tests available. field of developing, improving and evaluating www.sanquin.nl essential diagnostic tests and methods for tropical infectious diseases, as well as having The Swammerdam Institute of comprehensive expertise on epidemiological Life Sciences (SILS) is a renowned studies. The institute advises and supports research institution affiliated to the University of other organisations, especially in Amsterdam with extensive knowledge about low-incomecountries, in their efforts to the functioning of the living cell. diagnose those diseases and take necessary Biological processes are studied at the action against them. molecular, cellular,cellular network and www.kit.nl organism level. Processes that take place within and between cells, such as signal transduction, growth, cell division and the structure of chromatin are also studied. SILS is a multidisciplinary research institute where researchers combine knowledge from many areas of science: biology, biochemistry, biophysics, medicine, and data analysis and information technology. The institute offers expertise and support for different projects using its exceptional range of equipment. The facilities of SILS comprise state-of-the-art microscopes, mass spectrometry, advanced micro-array technology, bio-informatics and electrophysiology for brain research. www.sils.nl

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Shared resources

A portfolio of facilities & tools Databanks The universities and research institutes in Amsterdam The Netherlands Brain Bank (NBB) supplies the share a great many resources. Life sciences companies in international scientific community with clinically and the region can take advantage of facilities and neuropathologically well-documented brain tissue of high specialised equipment on offer at the institutes in the area. quality. The specimens collected by the NBB are obtained The Amsterdam Biomed Cluster and the Life Sciences from donors with a variety of neurological and psychiatric Center Amsterdam have detailed knowledge of all disorders, but also of non-diseased donors. These include: expertise centers, databanks, materials, patient cohorts Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and facilities and equipment. The LSCA can assist by (MS), and schizophrenia. providing tailored advice and contacting experts for www.brainbank.nl support. Materials

Databanks The Netherlands Cancer Institute possesses a large collection of cancer related mouse models and tissue Licencing cultures. Several research programmes all over the world Expertise Opportunities Centers use the models and cultures developed and created here. Shared Resources Another unique mouse model is available from AMCAS, a spin-off from the AMC. The HIS-model with a human-like Facilities & Materials Equipment immune system, serves therapeutic fields such as infectious diseases, auto-immune diseases and cancer. It Patient is also a source model for the generation of human T-cells Cohorts and disease specific T-cell receptors. www.amcas.nl Centers of expertise Amsterdam has well connected, internationally recognised Patient cohorts expertise centers in all its six fields of excellence. Extensive patient cohorts are available in Amsterdam from For example, the NKI for cancer research, the NIN on the university hospitals, knowledge institutes like the neuroscience and Sanquin in the fields of infectious NKI-AvL, NIN and Sanquin. Various contract research diseases and immunology. The region has renowned organisations, like IATEC and Quintiles, also have access imaging expertise through the Image Analysis Center to special cohorts; they can also assist in trial design and (IAC) of the VUmc and the Center of Advanced execution. Patient cohorts have been established for Microscopy (CAM) of the AMC. On the Medical Business major chronic and infectious diseases and for neurological Park, the Spinozacenter for Neuroimaging is currently and psychiatric disorders. being developed. The expertise centers have important scientific and social functions in public-private partnerships and through their cooperation with universities and businesses.

Licensing Opportunities The Life Sciences Center Amsterdam is your point of entry to innovative life sciences related technologies from the universities and knowledge institutes. An up-to-date list of the licensing opportunities available for technology transfer is available via the Amsterdam Biomed Cluster website www.amsterdambiomed.nl/lsca

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Key locations

Science Park Amsterdam

Science Park Amsterdam is an internationally renowned The National Institute for Subatomic Physics (NIKHEF) centre for scientific research, education and knowledge- co-ordinates and supports important activities in the field related business activities. Science Park Amsterdam has of experimental subatomic and high-energy physics. Nik- been devoted to science for over half a century. Because hef possesses thirteen cleanrooms up to class 1000 and of its strategic city location, Science Park Amsterdam is up to a size of 170 m2. The cleanrooms are available for denoted a key area for developing knowledge-intensive both the knowledge institutes and businesses. activities in the municipality. In addition, around 90 www.nikhef.nl national and international companies have set up busi- ness, chiefly in (Life) Sciences and ICT related areas, and The Institute for Atomic and Molecular Physics mutu¬ally benefit from each other’s knowledge and pre- (AMOLF) is a Dutch organisation for fundamental research sence. In the field of Life Sciences e.g. Agendia, BioDe- in physics. One of AMOLF’s research areas is the physics of tection Systems, SMS Oncology, Pickcell Laboratories and life processes, the research is conducted in the nanoCenter, DEAM have set up office in Science Park Amsterdam. a facility specialised in nanofabrication and nanotechnology. The facility is primarily used for combined Life Sciences Science Park Amsterdam is currently expanding rapidly research. Nanotechnology researchers form different and will eventually provide a total of 500,000 sq. meters research disciplines have access to the facility, which has its of office space, laboratories and educational buildings, a own 57 m2 cleanroom. hotel, conference facilities, sports and cultural provisions, www.amolf.nl hundreds of homes, childcare and a railway station. A large number of top-level knowledge institutes are loca- SARA Computing and Networking Services is a national ted on the Park. centre of expertise in the fields of supercomputing, high- performance networking and infrastructure services. SARA The University of Amsterdam Faculty of Science will houses and manages the national supercomputer and acts have 2,000 students and 1,500 staff working together in a as an important link in groundbreaking scientific research brand new building, of which 55,000 m2 opened in 2009 for e-science projects at Science Park Amsterdam. It sup- on Science Park Amsterdam. The accommodation creates ports several research projects from several research areas an exceptional environment for Life Sciences related including Life Sciences, especially with computer model- expertise and is important for cross-sectoral development, ling and dataprocessing. with the Biology, Medical Biology, Information Science, www.sara.nl Astronomy, Chemistry, Mathematics, Physics and Physical Geography departments located in the same building. The Amsterdam Internet Exchange (AMS-IX) has two www.science.uva.nl of its main infrastructure locations on the Science Park, at NIKHEF and SARA. The optic connections to four The National Research Institute for Mathematics and additional locations in Amsterdam makes the AMS-IX Computer Science (CWI) performs fundamental scientific the largest Internet hub in the world, measured both by research. CWI transfers the acquired knowledge to society number of members and by traffic. and industry. The institute runs projects on societally www.amst-ix.net relevant themes: Earth & Life Sciences, Data explosion, Social Logistics and Software as Service. Mathematics and computer science gain ever increasing importance in the Life Sciences. www.cwi.nl 24

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Medical Business Park AMC Medical Trade Park

The total Medical Business Park AMC site measures Almere is a fast growing, relatively new city, in the 640,000 sqm., with the present buildings occupying Amsterdam Metropolitia Area. Almere is actively about 450,000 sqm of floor space. With AMC at its heart, promoted as Health City where much attention is paid to the Medical Business Park is an ideal location innovation and collaboration between companies, for Health-related Life Sciences companies. Seven institutes, hospitals and local government. With a national and research institutes are located in the park. business-to-business approach there are many possibilities The Medical Business Park focuses on medical and for exchange of knowledge, products and services. education-related organisations. Currently, the new Medical Trade Park is being developed The goal is to attract life sciences companies active in in the Almere Poort area. The location is centrally located, biopharmaceuticals, medical devices, and patient care well connected, with enough space for the settlement of systems, and to promote the creation of new businesses. new businesses. It has a central focus on Medical Incubators in the Medical Business Park facilitated the Technology. start-up phase and initial growth of companies like AMT www.almere.nl and AIMM Therapeutics. www.mbpamsterdam.com Solvay Science Park Weesp At the site of the AMC and Medical Business Park AMC a number of institutes can be found. The Solvay site in Weesp is located in the Amsterdam Metropolitan Area. The site has a total surface The NIN, AMC, UvA and VU together are developing the area of 35 ha with 66.000 sqm. built up area, including Spinoza Center for Neuroimaging. The new center for facilities for R&D, manufacturing as well as office and human imaging will house a 3T and a 7T MRI scanner and warehouse space. Solvay Pharmaceuticals is currently will allow researchers to make new connections between investigating the possibilities for developing the site in basic neuroscience research and research using MRI. This Weesp into an ‘open innovation’ life science campus. The new multidisciplinary approach and the use of advanced advantage of the proposed ‘open innovation’ life science equipment will ensure important expertise and will streng- park concept is to share R&D services and facilities. then the links between fundamental research and practical Potential external candidates will benefit an excellent patient care. The state-of-the-art facilities will be used for location and a full scale R&D infrastructure with all both research and hospital purposes. necessary permits. Other parties that are located on the site are Fort Dog Animal Health (US) and Dishman (India). The Netherlands Institute for Pigment Disorders (SNIP) www.solvaypharmaceuticals.nl is a highly specialised department for the diagnosis and treatment of pigment disorders of the skin. The institute works closely with the AMC’s department of dermatology and carries out research on the causes and mechanisms of pigment disorders, as well as specialised treatments including pigment cell transplantation and laser therapy. Since 2004, the SNIP’s range of operations has expanded through the addition of a Centre for Laser Dermatology in which patient care, training and research are combined at the highest levels. The institute uses seven advanced lasers for treating pigment disorders, vascular aberrations and excessive hair growth. www.pigmentdisorders.com 26

‘…technology or a patent alone will not do the job…’

Prof. Dr. Dinko Valerio General Partner, Aescap Venture Management and Founder and former CEO of Crucell

‘For a long time the European biotech industry But today, Crucell is the largest independent lagged seriously behind that of the United States. vaccine company in the world. This could not have European universities performed strongly from a been accomplished without the strong scientific scientific point of view but poorly in commercialisa- heritage present in the Netherlands. tion: the so-called European paradox. In the past, commercial initiatives were frowned upon, but Starting a biotech company implies that you aspire today academic institutes go full out to realize the to become a world leader in your specific area of commercial potential of their inventions. Aescap’s expertise. To achieve this, you will need to involve goal is to help building these initiatives into the organisations and individuals that share this ambition world leading companies of the future. one hundred percent. Technology or a patent alone will not do the job. In the Amsterdam Metropolitan When I started Crucell in 1993, it was my dream to Area you’ll find a mature company structure and all turn it into a company with an exciting cultural mix the ingredients to make your biotech business into a of science and entrepreneurship. At that time the success.’ reactions of my peers were mixed, to say the least.

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A fully mature life sciences sector, the Amsterdam Metropolitan Area offers everything from fundamental research to marketing and sales. Amsterdam life sciences in business

70 highly innovative life sciences companies and more Many Dutch subsidiaries from foreign life sciences In the Amsterdam Metropolitan Area over 300 companies use the Amsterdam Metropolitan Area region companies, including supply companies, service to perform their international activities. A relatively high companies, and investors, are active in the health-related number of companies in the Area is active within sales & life sciences. This number includes over 70 highly marketing, and the service sector. The Amsterdam innovative, R&D intensive life sciences companies, and Metropolitan Area is clearly a gateway for managing about 110 supporting companies that have active European business activities. specialisations in the field. One can find a balanced mix of biotechnology, pharma, medical technology and A selection from the value ICT-related life sciences companies. chain The life sciences sector in the region is mature, with You can find organisation profiles of all the life sciences companies active in all parts of the value chain, from related businesses (and institutes) within the Amsterdam fundemnetal research to marketing and sales. large Metropolitan Area online via the Know-who Know-how multinationals such as Solvay, Genzyme, MSD and directory of the Amsterdam BioMed Cluster at Quintiles are typically distributed over different locations www.amsterdambiomed.nl/participants in the larger Amsterdam Metropolitan Area, while small and medium sized enterprises are typically clustered Below we provide, per category of the life sciences value around the universities and science parks. chain, some fine examples of regional businesses with About half of the highly innovative companies are young their products and services. and spin offs from the Amsterdam based universities and research institutes. Applied research & product development Agendia started as a spin-off from the Netherlands Fundamental and applied research is conducted within Cancer Institute (NKI) in 2003. The company is pioneering companies in addition to the research institutes, the development and commercialisation of validated tests universities and medical centres. Most of the that assist healthcare professionals and pharmaceutical companies conducting research combine applied research companies to determine the diagnosis, prognosis and with product development. No less than ten Contract/ therapeutic responsiveness of cancers in individual Clinical Research Organisations are based in the region. patients. With MammaPrint™, Agendia became the first

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Companies and Organisations in the Life Sciences value chain

Fundamental Research Applied Research Product Development Clinical Trials Academic Centre for Dentistry in Academic Centre for Dentistry in Abbott BV Clintec International B.V. Amsterdam (ACTA) Amsterdam (ACTA) ACE Pharmaceuticals BV Global Clinical Services Agendia Agendia Agendia IATEC Academic Medical Center (AMC) Academic Medical Center (AMC) Agriom B.V. ICTOM BV Institute for Atomic and Molecular Physics Amcas BV AIMM Therapeutics INC Research B.V. (AMOLF) Institute for Atomic and Molecular Amcas BV PAREXEL Nederland B.V. Amsterdam Institute of Viral Genomics Physics (AMOLF) Amsterdam Molecular Therapeutics (AMT) PSR Group BV B.V. Amsterdam Institute of Viral Genomics ARKRAY Europe BV Quintiles Central Veterinary Institute of B.V. Arthrogen RKS Consultancy Wageningen UR Amsterdam Molecular Therapeutics Artu Biologicals Europe B.V. Sanquin Pharmaceutical Services (SPS) Cyclotron VU (AMT) A-Skin B.V. SutureAid Europe Headquaters University of Applied Sciences (HvA) ARKRAY Europe BV Avantium Teva Pharma Netherlands University of Applied Sciences Arthrogen Bayer CropScience B.V. (INHolland) Artu Biologicals Europe B.V. Bio Affi nity Center (BAC BV) IMARES A-Skin B.V. BioDetection Systems B.V. Institute for Biodiversity and Ecosystem Avantium BioSemi Dynamics (IBED) Bio Affi nity Center (BAC BV) BMEYE B.V. Jan van Breemen Institute BioDetection Systems B.V. Cidrux B.V. KIT Biomedical Research Central Veterinary Institute of Clinquest Group National Institute for Wageningen UR DC4U Subatomic Physics (NIKHEF) Cidrux B.V. DCPrime Netherlands Cancer Institute (NKI-AVL) Cyclotron VU Deam Corporation Netherlands Institute for Neuroscience DC4U Dynomics BV (NIN) DCPrime Enceladus Netherlands Institute for Systems Biology Deam Corporation Exsilent (NISB) Dynomics BV Falco Biotherapeutics Neuroscience Campus Amsterdam Emotional Brain bv FeyeCon NIPED (Institute for Prevention and Early Enceladus Finapress Medical Systems B.V. Diagnostics) Falco Biotherapeutics Fornix BioSciences N.V. The Netherlands Institute for Pigment Grontmij | AquaSense. Genzyme Nederland Disorders HAL Allergy BV HAL Allergy BV Sanquin Blood Supply Foundation / CLB Hogeschool InHolland, opleiding Hep-Art Medical Devices Swammerdam Institute for Life Sciences mondzorgkunde Hospira (SILS) University of Applied Sciences (HvA) IFF University of Amsterdam (UvA) IMARES, vestiging IJmuiden Inspektor Research VU&Vumc Immunaffect B.V. Kiadis Pharma Institute for Biodiversity and Kreatech Holding B.V. Ecosystem Dynamics (IBED) - UvA Lipid Nutrition Jan van Breemen Institute Lundbeck BV Kiadis Pharma MDCL N.V. KIT Biomedical Research Merck BV KSYOS TeleMedical Centre Merck Sharp & Dohme B.V. Merck BV Metris National Institute for Microbiome Subatomic Physics (NIKHEF) Microvision Medical Holding B.V. Netherlands Cancer Institute (NKI-AVL) Motek Medical Netherlands Institute for Neuroscience MRC Holland B.V. (NIN) Norgine BV Netherlands Institute for Systems Nycomed bv Biology (NISB) O2view Neuroscience Campus Amsterdam OncoMethylome Sciences B.V. NIPED (NDDO Institute for Prevention ORCA Therapeutics B.V. and Early Diagnostics) PAREXEL Nederland B.V. Norgine BV Pepscan Systems B.V. Nycomed bv Personal Health Insitute International OncoMethylome Sciences B.V. Personal Space Technologies ORCA Therapeutics B.V. Pharmachemie B.V. Pepscan Systems B.V. Prionics BV PickCell Laboratories BV Sanquin Reagentia Prionics BV Skyline Diagnostics BV The Netherlands Institute for Pigment SMS-Oncology Disorders Solvay Pharmaceutics Sanquin Blood Supply Foundation SutureAid Europe Headquaters Sanquin Reagentia Synaptologics BV Skyline Diagnostics BV TeleMetronics biometry B.V. Solvay Pharmaceutics TIPb: Applied Industrial Process Control Stega Winclove Bio Industries Swammerdam Institute for Life Wyeth Pharmaceuticals B.V. Sciences (SILS) YouMedical TIPb: Applied Industrial Process Control University of Amsterdam (UvA) Valetta Health VU&Vumc Winclove Bio Industries 29

Companies and Organisations in the Life Sciences value chain

Production Distribution Sales & Marketing Services ACE Pharmaceuticals BV Abbott BV Abbott BV Aescap Venture AIMM Therapeutics ACE Pharmaceuticals BV Agendia Agilent Technologies Netherlands B.V. Amsterdam Molecular Therapeutics Agendia AKZO Nobel Agriom B.V. (AMT) AKZO Nobel Amcas BV AMC Medical Business Park Arthrogen Artu Biologicals Europe B.V. Artu Biologicals Europe B.V. Amspar BV Artu Biologicals Europe B.V. Bayer CropScience B.V. Bayer CropScience B.V. Amsterdam BioMed Cluster A-Skin B.V. Beun De Ronde B.V. Bayer Healthcare B.V. Amsterdam Innovation Motor (AIM) Avantium Cargill B.V. Biogen Idec B.V. Arnold & Siedsma Bayer CropScience B.V. Dr. Fisher Farma B.V. Bruker Daltonics B.V. Amsterdam Science Park NV Bio Affinity Center (BAC BV) Fornix BioSciences N.V. Cargill B.V. Axil BioDetection Systems B.V. Henry Schein Dental Dionex Benelux B.V. Berkvens Management and Investment BMEYE B.V. Imres b.v. Dr. Fisher Farma B.V. Biogeneration Ventures Cargill B.V. ITK Diagnostics B.V. Exsilent BioPartner Start-up Ventures DC4U Prionics BV Ferring CMS Derks Star Busmann DCPrime RKS Consultancy Finapress Medical Systems B.V. Cortical Studios Deam Corporation Sandoz BV Fornix BioSciences N.V. Dentalview B.V. Enceladus Schiphol Group Genzyme Nederland DiaDent Europe BV Farmalyse BV Tramedico Holding B.V. HAL Allergy BV Dienst Economische Zaken Finapress Medical Systems B.V. Henry Schein Dental DOCS Int. HAL Allergy BV Hospira Drug Discovery Factory BV Hospira IFF Hilversum Ernst & Young Sector Health Sciences Inspektor Research Imres b.v. Expat Center Amsterdam Kiadis Pharma Kreatech Holding B.V. Farmalyse BV Kreatech Holding B.V. LIGHTHOUSE Forbion Capital Partners Lipid Nutrition Lundbeck BV General Healthcare Investment Merck Sharp & Dohme B.V. MDCL N.V. Corporation Metris Meda Pharma BV Grontmij | AquaSense. O2view Medidis Hans Mak Instituut ORCA Therapeutics B.V. Mercantum Hezelburcht BioTop BV Pharmachemie B.V. Merck BV Hyphen Projects Sandoz BV Millipore B.V. iMMovator Crossmedia Network Solvay Pharmaceutics Nestlé Nederland InDutch Recruitment services SutureAid Europe Headquaters Norgine BV Innopact Synco Biopartners Personal Space Technologies JPG Adviesgroep bv TeleMetronics biometry B.V. Pharmachemie B.V. Chamber of Commerce Amsterdam Winclove Bio Industries Prionics BV Knowledge Transfer Office UvA Pronova Medical Life Sciences Center Amsterdam (LSCA) Roche Diagnostics Nederland BV Life Sciences Fonds Amsterdam (LSFA) Sandoz BV Life Sciences Partners (LSP Group) Senju Pharmaceutical Europe Macrogen Solvay Pharmaceutics Maxwell Group SutureAid Europe Headquaters MeDaVinci TeleMetronics biometry B.V. Medifocus BV Teva Pharma Nederland MedSciences Capital Tramedico Holding B.V. MEDTECHPARTNERS Van Vliet Medical Supply Micronic B.V. Visual Sonics Europe Middenduin Life Sciences Vitaboost International BV Mount Medical Winclove Bio Industries NextStage Wright Medical EMEA Headquarters NHN - Ontwikkelingsbedrijf Wyeth Consumer Health Care Noord-Holland Noord Wyeth Pharmaceuticals B.V. PharmAccess YouMedical PQS Group BV PriceWaterhouseCoopers Prinsze Pharma Concepts SARA Computing and Networking Services Schretlen & Co Science Park Amsterdam Seijgraaf Consultancy BV Semper Healthcare Signifix SOLV Advocaten Science Park Amsterdam Center for Entrepreneurship Squarewise Innovation Synaptologics BV Syntens Technology Transfer Office AMC Technology Transfer Office UvA Technopolis BV TIPb: Applied Industrial Process Control Transplant Creations Van Vliet Medical Supply Vectrix VenGen via Flaminia Vintura BV Yellow Research Yxion BV Vintura BV Yellow Research Yxion BV

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company to commercialise a prognostic test that predicts Sanofi Pasteur MSD was founded in 1994 as a joint the risk of breast cancer recurrence. It became the first venture between Sanofi Pasteur and Merck&Co. It is the in vitro Diagnostic Multivariate Index Assay (IVDMIA) to only European company dedicated exclusively to vaccine receive clearance from the US Food and Drug production. The Dutch production site of Sanofi Pasteur Administration (FDA). The information obtained is crucial MSD in Hoofddorp, in the Amsterdam Metropolitan Area to enable physicians to determine the best course of develops and sells a wide array of vaccines. Sanofi Pasteur treatment for an individual patient and for drug MSD has long been involved in vaccination campaigns for developers to differentiate between responders and children, adults and the elderly across Europe, as well as non-responders when setting up clinical trials. in supplying vaccines for travellers or those facing health www.agendia.com risks at work. Sanofi Pasteur MSD is the largest producer www.mammaprint.com of influenza vaccines in the world. www.spmsd.nl Production & manufacturing Solvay Pharmaceuticals is a large chemical and Contract research pharmaceutical company with a global market. Solvay Quintiles, located in Hoofddorp, is the first Dutch clinical invests in modern research technologies and collaborates and commercial service provider to concentrate with international scientific partners. The company has five exclusively on the healthcare industry. The company has important research and production facilities worldwide; the largest clinical research department of any one of the biggest facilities is based in Weesp, near organisation in the Netherlands. The hub employs Amsterdam. It is the main plant for research on diseases professionals in a variety of important therapeutic areas, related to the central nervous system and the brain, but such as oncology, cardiovascular & diabetes, central also for vaccine development and production. In total, nervous system, infectious diseases and internal medicine. Solvay has over 1,350 employees in the Netherlands. A Quintiles Commercial Services provides marketing and few of the key products created by Solvay in Weesp are sales services for the healthcare industry. Additionally, the annual influenza-vaccine, a compound that reduces Quintiles Consulting helps secure market access for the symptoms of late stage Parkinson’s Disease, a widely pharmaceutical products or medical devices. used progesterone hormone and Lactulose an active www.quintiles.com substance in laxatives. The most important product discovered and developed in the research department is Sales & services fluvoxamine, an SSRI antidepressant. In 2008, the US FDA Amsterdam BioPortEurope was recently established approved a controlled-release formulation of fluvoxamine, to specifically provide integrated business services for to be marketed as Luvox®. foreign life sciences companies entering the European www.solvaypharmaceuticals.nl market. In the initial phase, services are being developed for Indian life sciences companies. In later phases, the The Dutch sales office of Merck Sharp & Dohme opened services will also be available to companies from other in Amsterdam in 1954. MSD then relocated to countries. Through Amsterdam BioPortEurope, in the Amsterdam Metropolitan Area. The company has companies can receive support with regards to a market grown to become a dynamic production and distribution entry strategy, new product introduction, sales channel centre for Europe and other continents. From Haarlem, and local presence build-out, partnership sourcing and MSD distributes medicines to more than 140 countries venture capital sourcing. MSD is a research-intensive company that invests www.amsterdambiomed.nl/bpe extensively in the research and development of new medicines. Additionally, MSD also looks into possible new Seijgraaf BV is a consultancy agency that gives advice applications for existing medicines like Mectizan® which within the healthcare system mainly on strategy and policy is a broad-spectrum antiparasitic agent, mainly used in structures related to, and resulting from, the finance humans in the treatment of river blindness, but is also structures of the Dutch health care system. Their expertise effective against other worm infestations. is in the policy fields covering medical devices, www.msd.nl pharmaceuticals, and practitioners operating within healthcare and in-hospital activities. Seijgraaf BV maintains

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a vast network that covers all involved and relevant organisations operating in this sector of the market. www.seijgraaf.nl

Aescap Venture is a venture capital company investing in private medical companies in Europe working on the diagnosis or treatment of human diseases. Aescap chose to settle in Amsterdam, because of Amsterdam’s strong financial center, well connected to its European portfolio companies. With its company-building experience and venture capital expertise, Aescap Venture is positioned perfectly to help companies realise their full potential. www.aescap.com

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Amsterdam Metropolitan Area, Life Sciences locations

EUROPE NETHERLANDS AMSTERDAM AIRPORT AREA

AMSTERDAM Amsterdam Almere

A 9 The Hague Utrecht

Rotterdam

A 7

IJMUIDEN A 8

A 9

N 202 N 247

PORT OF AMSTERDAM HAARLEM

A 200 ALMERE

A 205 AMSTERDAM A 9 A 10 CITY CENTER

A 6 re-routed A9 SCIENCE PARK A 5 A 10 AMSTERDAM MEDICAL TRADE PARK ALMERE N 201 A 1 AMSTERDAM AIRPORT A 4 SCHIPHOL AMSTELVEEN A 9 WEESP N 208 HOOFDDORP

SOLVAY SCIENCE A 9 CAMPUS Beechavenue MEDICAL BUSINESS NAARDEN

N 205 PARK AMSTERDAM

AALSMEER BUSSUM A 1

re-routed N201

A 4 N 201 A 2

N 201 N 207 HILVERSUM

Rotterdam/The Hague (50 km) Utrecht (45 km)

© AMSTERDAM AIRPORT AREA

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Universities, Institutes, EUROPE NETHERLANDS AMSTERDAM AIRPORT AREA Expertise Centers

AMSTERDAM Amsterdam Almere

Companies

A 9 The Hague Utrecht

Rotterdam Science Parks A 7

IJMUIDEN ZAANSTAD A 8

A 9

N 202 N 247

PORT OF AMSTERDAM HAARLEM

A 200 ALMERE

A 205 AMSTERDAM ZANDVOORT A 9 A 10 CITY CENTER

A 6 re-routed A9 SCIENCE PARK A 5 A 10 AMSTERDAM MEDICAL TRADE PARK ALMERE N 201 A 1 AMSTERDAM AIRPORT A 4 SCHIPHOL AMSTELVEEN A 9 WEESP N 208 HOOFDDORP

SOLVAY SCIENCE A 9 CAMPUS Beechavenue MEDICAL BUSINESS NAARDEN

N 205 PARK AMSTERDAM

AALSMEER BUSSUM A 1 re-routed N201

A 4 N 201 A 2

N 201 N 207 HILVERSUM

Rotterdam/The Hague (50 km) Utrecht (45 km)

© AMSTERDAM AIRPORT AREA

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Edition: AIM Amsterdam Innovation Motor AIM Amsterdam Innovation Motor Amsterdam, October 2009 Editor in Chief: AIM P.O. Box 2852, NL-1000 CW Amsterdam, Concept/Design: Clev, Bert Tressel the Netherlands Editors: Txtworks T: +31 (0)20 - 524 11 20 Account: Clev, Leanne Bogers E: [email protected] Design/Typography: Clev, Harrie van Wees www.aimsterdam.nl Photography (main articles): Jan van Breda www.amsterdambiomed.nl Photography: Photobank Intranet Amsterdam Map (page 32-33): Amsterdam Airport Area Print: Zwaan printmedia

Life Sciences in Business Amsterdam Innovation Motor AIM Amsterdam