Abhik Saha

ABHIK SAHA, Ph.D.

Present Affiliation: Assistant Professor Wellcome Trust/DBT IA Fellow Department of Life Sciences Presidency University 86/1, College Street, - 700073 , Phone: 91-9874924838 (Mob) Email: [email protected] [email protected]

Home Address: BA/29, Baguiati, Deshbandhu Nagar, Kolkata 700 059, West Bengal, INDIA Nationality: Indian Date of Birth: 17th Nov. 1975

Academic Career:  Post-Doctoral (2007-2012): Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA  Ph.D. (2001-2007): Department of Microbiology, Bose Institute, Kolkata, INDIA, Awarded from , Kolkata, INDIA  M.Sc. (1998-2000): with special paper Microbiology, , Kolkata, INDIA  B.Sc. (1995-1998): Chemistry (Major) with Physics and Mathematics, University of Calcutta, Kolkata, INDIA

Research Experience:  2012 – current: Joined as an Assistant Professor in Dept. of Biotechnology, Presidency University, Kolkata  2007 – 2012: Worked with Prof. Erle S Robertson at Dept. of Microbiology, University of Pennsylvania School of Medicine, USA as a postdoctoral research scholar  2001 – 2007: Completed my Ph.D. program (2001-2007) at Dept. of Microbiology, Bose Institute, INDIA, under the guidance of Dr. Sujoy K. Das Gupta. Thesis title: “The 16-kDa dormancy promoting α-crystallin-like protein of Mycobacterium tuberculosis – its structure, mode of action, and development of specific inhibitors”.

Research Interest: Cancer Biology, Tumor Virology, Host-pathogen interaction - Deregulation of multiple cellular signaling pathways in disease pathogenesis - particularly in Cell-Cycle, Apoptosis, Autophagy and Ubiquitin-Proteasome mediated pathways, Unfolded Protein Response (UPR), Epigenetic regulation.

List of Publications: h-index: 15 A. Research Articles: 1. Bhattacharjee S, Bose P, Patel K, Roy SG, Gain C, Gowda H, Robertson ES, Saha A*. (2018). Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Cell Death Dis. 2018 May 22;9(6):605. * Corresponding Author. 2. Pei Y, Banerjee S, Sun Z, Jha HC, Saha A, Robertson ES. (2016). EBV nuclear antigen 3C mediates regulation of E2F6 to inhibit E2F1 transcription and promote cell proliferation. PloS Pathogens, 12(8):e1005844. 3. Saha A, Jha HC, Upadhyay SK, Robertson ES. (2015). Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection. Proc Natl Acad Sci U S A, 112(37):E5199-207. 4. Dzeng RK, Jha HC, Lu J, Saha A, Banerjee S, Robertson ES. Small molecule growth inhibitors of human oncogenic gammaherpesvirus infected B-cells. Mol Oncol. 2015 Feb;9(2):365-76. 5. Jha HC, Aj MP, Saha A, Banerjee S, Lu J, Robertson ES. (2014). EBV essential antigen EBNA3C attenuates H2AX expression. J Virol.; 88(7):3776-88. 6. Jha HC, Lu J, Saha A, Cai Q, Banerjee S, Prasad MA, Robertson ES. (2013). EBNA3C-mediated regulation of aurora kinase B contributes to Epstein-Barr virus-induced B-cell proliferation through modulation of the activities of the retinoblastoma protein and apoptotic caspases. J Virol.; 87(22):12121-38.

Curriculum Vitae 1 Abhik Saha

7. Banerjee S, Lu J, Cai Q, Saha A, Jha HC, Dzeng RK, and Robertson ES. (2013). The EBV latent antigen 3C inhibits apoptosis through targeted regulation of interferon regulatory factors 4 and 8. Plos Pathogens, 9(5):e1003314. 8. Jha HC, Upadhyay SK, Aj MP, Lu J, Cai Q, Saha A, Robertson ES. (2013). H2AX Phosphorylation Is Important for LANA-Mediated Kaposi's Sarcoma-Associated Herpesvirus Episome Persistence. J Virol, 87(9):5255-69. 9. Saha A, Lu J, Morizur L, Upadhayay SK, AJ Prasad M, Robertson ES. (2012). Epstein-Barr virus Nuclear Antigen 3C Blocks E2F1 Induced Apoptotic Pathway in EBV Infected Cells. Plos Pathogens; 8(3): e1002573. 10. Lu J, Verma SC, Cai Q, Saha A, Dzeng R, Robertson ES. (2012). Enhanced KSHV latent infection and proliferative capacity during primary infection. Plos Pathogens; 8(1):e1002479. 11. Cai Q, Guo Y, Xiao B, Banerjee S, Saha A, Lu J, Glisovic T, Robertson ES. (2011). Epstein-Barr virus Nuclear Antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. Plos Pathogens; 7(12): e1002418. 12. Saha A, Halder S, Upadhayay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES. (2011). EBNA3C Facilitates G1-S Transition by Stabilizing and Enhancing the Function of Cyclin D1. Plos Pathogens; 7(2):e1001275. 13. Saha A, Bamidele A, Murakami M, Robertson ES. (2011). EBNA3C Attenuates the Function of p53 through Interaction with the Inhibitor of Growth Family Proteins, 4 and 5. J Virol.; 85(5):2079-88. 14. Xiao B, Verma SC, Cai Q, Kaul R, Lu J, Saha A, Robertson ES. (2010). Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores. J Virol.; 84(19):9718-32. 15. Yi F*, Saha A*, Murakami M*, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES. (2009). Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities. Virology; 388(2):236-47. * Equal contribution. 16. Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES. (2009). Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2. J Virol.; 83(9):4652- 69. 17. Mitra G, Saha A, Gupta TD, Poddar A, Das KP, Das Gupta SK, Bhattacharyya B. (2007). Chaperone-Mediated Inhibition of Tubulin Self-Assembly. Proteins; 67(1):112-20. 18. Sharma A, Saha A, Bhattacharjee S, Majumdar S, Das Gupta SK. (2006). Specific and Randomly Derived Immunoactive Peptide Mimotopes of Mycobacterial Antigens. Clin Vaccine Immunol.; 13(10):1143-54. 19. Saha A, Sharma A, Dhar A, Bhattacharyya B, Roy S, Das Gupta SK. (2005). Antagonists of Hsp16.3, A Low- Molecular-Weight Mycobacterial Chaperone and Virulence Factor, Derived from Phage-Displayed Peptide Libraries. Appl Environ Microbiol.; 71(11):7334-44. B. Reviews: 1. Ghosh Roy S, Robertson ES, Saha A*. (2016). Epigenetic impact on EBV associated B-cell lymphomagenesis. Biomolecules, 6(4), pii: E46. * Co-corresponding Author. 2. Bhattacharjee S, Ghosh Roy S, Bose P, Saha A*. (2016). Role of EBNA3-family proteins in EBV associated B- cell lymphomagenesis. Front Microbiol, 7:457. * Corresponding Author. 3. Saha A, Robertson ES. (2013). Insights into the Epstein-Barr virus nuclear antigen 3C mediated deregulation of cell-proliferation and apoptosis. Future Microbiol, 8(3):323-52. 1. Saha A, Robertson ES. Functional Modulation of the Metastatic Suppressor Nm23-H1 by Oncogenic Viruses. FEBS Lett. 2011; 585(20):3174-84. 2. Saha A, Robertson ES. Epstein-Barr virus in B-cell Lymphoma: Pathogenesis and Clinical Outcomes. Clin Cancer Res. 2011; 17(10):3056-63. 3. Saha A*, Kaul R*, Murakami M, Robertson ES. Tumor viruses and cancer biology: modulating signaling pathways for therapeutic intervention. Cancer Biol Ther. 2010; 10(10):961-78. * Equal contribution. 4. Kumar P*, Saha A*, Robertson ES. Epstein-Barr virus Hijacks Cell-Cycle Machinery: EBV can perturb cellular pathways, contributing to the development of cancer. Microbe. 2010; 5: 1-6. * Equal contribution. 5. Kumar P, Murakami M, Kaul R, Saha A, Cai Q and Robertson ES. Deregulation of Cell Cycle Machinery by the Epstein-Barr virus Nuclear Antigen 3C. Future Virology. 2009; 4(1):1-8. C. Book Chapters: 1. Saha A* and Robertson ES. Microbiome and Human Malignancies. Robertson ES Ed. Caister-Horizon Press, London England. 2018. Book Chapter. * Co-orresponding Author. 2. Upadhayay SK, Jha HC, Saha A, Robertson ES. Lymphocryptoviruses: EBV and Its Role in Human Cancer. Robertson ES Ed. Springer Science+Business Media, LLC, New York, USA. 2012. Book Chapter. 3. Sims K, Saha A, and Robertson ES. Epstein-Barr virus Nuclear Antigen Family 3 in Regulation of Cellular Processes. Robertson ES Ed. Caister-Horizon Press, London England. 2009. Book Chapter. Curriculum Vitae 2 Abhik Saha

D. Patent Filing: 1. Robertson ES, Saha, A. Therapeutic targets for EBV mediated malignancies. Disclosure submitted to the University of Pennsylvania technology Transfer Office. 2009. Appl. No. PENN ref. V5191, Filing Date – 05/26/2009. 2. Das Gupta, SK, Saha, A, Sharma, A, Roy, S, Bhattacharya, B, Chakrabarti, P. Peptide Antagonists for inhibiting Heat Shock Protein (Hsp16.3) of Mycobacterium tuberculosis. A patent application to United States Patent and Trademark Office (USPTO) has been made. Appl. No. 10/854,421, Filing Date – 05/26/2004. E. Presentations at Academic Conferences/Meetings: 1. Bhattacharjee S, Bose P, Ghosh Roy S, Gain C, Saha A. “Epstein - Barr Virus Nuclear Antigen EBNA3C Transcriptionally Modulates Autophagy Network- A Clue to B- cell Lymphomagenesis.” Poster and oral presentation in ‘19th Transcription Assembly Meeting’ at Bose Institute, Kolkata from November 8-9, 2016. 2. Saha A, Jha HC, Upadhyay SK, Robertson ES. “Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection”. Poster Presentation in 17th international Symposium on EBV and associated diseases – Zurich, Switzerland, on August 8-12, 2016. 3. Bhattacharjee S, GhoshRoy S, Bose P, Ghosh S, Saha A. “Epstein - Barr Virus Essential Antigen EBNA3C Deregulates UPR-Autophagy Network: A Clue To B-Cell Transformation”. Poster Presentation in 1st DELTAS Annual Meeting, Nairobi, Kenya, Africa on July 5-6, 2016. 4. Bhattacharjee S, GhoshRoy S, Bose P, Ghosh S, Saha A. “Epstein - Barr Virus Essential Antigen EBNA3C Deregulates UPR-Autophagy Network: A Clue To B-Cell Transformation”. Poster Presentation in a two-day meeting on “Epidemiological Transition” at Nairobi, Kenya, Africa, jointly organized by The African Academy of Sciences and the Royal Society of Tropical Medicine and Hygiene on July 7-8, 2016. 5. Bose P, Bhattacharjee S, GhoshRoy S, Som O, Ghosh S, Biswas N, Saha A. “Autophagy-Apoptosis Network could serve as an Alternative Therapeutic Approach Against Imatinib-Resistant Chronic Myeloid Leukemia”. Poster presentation at 23rd West Bengal Science and Technology Congress (WBSTC) organized by Presidency University, Kolkata from February 28-29, 2016. 6. Bhattacharjee S, GhoshRoy S, Bose P, Ghosh S, Som O, Chandra S, Saha A. “Epstein - Barr Virus Essential Antigen EBNA3C Deregulates UPR-Autophagy Network: A Clue To B-Cell Transformation”. Poster presentation at 23rd West Bengal Science and Technology Congress (WBSTC) organized by Presidency University, Kolkata from February 28-29, 2016. 7. Bhattacharjee S, Bose P, Ghosh Roy S, Chakraborty A, Saha A. “Epstein–Barr Virus Nuclear Antigen 3C Targeted UPR-Autophagy Network: Transformation of B-Cell & Lymphomagenesis”. Poster presentation at one day International Seminar on "Current Thoughts in Cell Sciences" organized by Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, Kolkata on November 8, 2015. 8. Bhattacharjee S, Ghosh Roy S, Bose P, Saha A. “Understanding the Molecular Cross talk between Unfolded Protein Response and EBV pathogenesis in developing B-cell Lymphomas”. Poster presentation in ‘Wellcome Trust/ DBT India Alliance Annual Fellows' Meeting at Hotel Novotel Hyderabad Airport, Hyderabad, from November 5-6, 2015. 9. Saha A. Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach. Poster presentation in a One-day National Symposium on ‘Modern Trends in Biological Sciences’ held at Presidency University, Kolkata on 21st February, 2014, organized by “The Physiological Institute” (an old organization established in 1951 by Prof. Sachidananda Banerjee in the Department of Physiology, Presidency College). 10. Saha A. Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach. Poster presentation in ‘Young Investigator Meeting’ held at Ramoji Film City, Hyderabad on 8-12th February, 2014, organized by IndiaBioscience.org and NCBS, Bangalore, sponsored by Wellcome Trust DBT Alliance and EMBO. 11. Banerjee S, Lu J, Saha A, Cai Q, Jha HC, Dzeng RK, Robertson ES. EBNA3C stabilizes IRF4 to promote B cell transformation by downregulating IRF8. Poster presentation in ‘International Congress on Oncogenic Herpesviruses and Associated Diseases’ held at Philadelphia, Pennsylvania, USA on August 1-4, 2012, organized by Abarmson Cancer Center at Penn Medicine, Perelman School of Medicine at the University of Pennsylvania, Penn Dental Medicine and the Wistar Institute. 12. Jha HC, Upadhyay SK, Saha A, Cai Q, Banerjee S, Lu J, Mahadesh P AJ, Robertson ES. EBNA3C mediated stabilization of aurora kinase B contributes to oncogenesis. Poster presentation in ‘International Congress on Oncogenic Herpesviruses and Associated Diseases’ held at Philadelphia, Pennsylvania, USA on August 1-4, 2012, organized by Abarmson Cancer Center at Penn Medicine, Perelman School of Medicine at the University of Pennsylvania, Penn Dental Medicine and the Wistar Institute. Curriculum Vitae 3 Abhik Saha

13. Lu J, Verma SC, Cai Q, Saha A, Dzeng RK, Robertson ES. The role of RBP-Jκ and epigenetic modifications in KSHV infection of human primary cells. Poster presentation in ‘International Congress on Oncogenic Herpesviruses and Associated Diseases’ held at Philadelphia, Pennsylvania, USA on August 1-4, 2012, organized by Abarmson Cancer Center at Penn Medicine, Perelman School of Medicine at the University of Pennsylvania, Penn Dental Medicine and the Wistar Institute. 14. Saha A, Murakami M, Kumar P, Robertson ES. Epstein - Barr virus Nuclear Antigen 3C critically modulates ubiquitin-proteasome pathway to regulate p53-Mdm2 status in EBV infected cells. Poster presentation in ‘34th Annual International Herpesvirus Workshop’, held at Cornell University, Ithaca, NY, USA from Nov 7-10, 2008. 15. Saha A, Murakami M, Robertson ES. Epstein - Barr virus Nuclear Antigen 3C critically modulates ubiquitin- proteasome pathway to regulate p53-Mdm2 status in EBV infected cells. Poster presentation in ‘International Conference on EBV’, held at Guangzhou, China from July 25-31, 2009. 16. Saha A, Sharma A, Dhar A, Bhattacharya B, Roy S, DasGupta SK. Peptide inhibitors of Hsp16.3, a small molecular weight mycobacterial chaperone and virulence factor. Poster presentation (awarded first prize) in the International Conference on ‘Functional Genomics for Novel Vaccine and Drug Design against Mycobacterial Infection (VDMI)’, Feb. 10-11, 2005, held at Indian Institute of Technology (IIT), Kharagpur, India, jointly organized by Dept. of Biotechnology, IIT, Kharagpur, INDIA and University of Bergen, Bergen, Norway.

Manuscripts under preparation/ under review: 1. Bhattacharjee S, Bose P, Patel K, Ghosh Roy S, Gain C, Gowda H, Robertson ES and Saha A. Epstein-Barr virus Nuclear Antigen 3C Promotes B-Cell Lymphomagenesis by Upregulating Autophagy. (Submitted to PloS Pathogens). 2. Ghosh Roy S, Bose P, Bhattacharjee S, Gain C, Ghosh S, Saha A. Unfolded Protein Response Regulates EBV Induced B-cell Lymphomagenesis. (Manuscript under preparation) 3. Bose P, Bhattacharjee S, Biswas N, Saha A. Profiling of Autophagy Markers in Imatinib Resistant Chronic Myeloid Leukemia cells. (Manuscript under preparation)

Other Conferences Attended: 1. The Cell Press–TNQ India Distinguished Lectureship Series 2017. “Understanding Inherited Breast and Ovarian Cancer: From Gene Discovery to Precision Medicine and Public Health” by Prof. Mary-Claire King on February 28, 2017. 2. Global Education Summit: The Future of the Sciences and the Humanities: Seeking Complexity’; Bicentenary celebration of Presidency University, Kolkata on January 9-11, 2017. 3. One day National Symposium on “The World of Microbes: Pathogenesis, Environment and Evolution” to commemorate 100 years of Bose Institute at Bose Institute, Kolakta on October 17, 2016. 4. Weekly departmental colloquium at Presidency University, Kolkata by Dr. Soumen Roy, Bose Institute, Kolkata on "Physics in medicine and biology: From image processing and diagnostics to phage-bacteria interactions" on March 9, 2016. 5. “Brain Awareness Program – Brain Fair & Brain Storming Sessions” at Presidency University, Kolkata from February 29 – March 1, 2016. 6. Served as a ‘Session Chair’ on “Molecular Dissection of Man-Environment Interaction” at 23rd West Bengal Science and Technology Congress (WBSTC) organized by Presidency University, Kolkata from February 28-29, 2016. 7. “Make in India-Challenge Ahead” BIOCHEM-2016 organized by Dept. of Biochemistry, University of Calcutta at Ballygunge Science College, University of Calcutta, Kolkata from February 26-27, 2016. 8. Weekly departmental colloquium at Presidency University, Kolkata by Prof. Abhijit Chakraborti, Saha Institute of Nuclear Physics, Kolkata on "Clinical Proteomics: a Decade in a non-Clinical Set-up" on February 17, 2016. 9. “Global Biotechnology Summit, 2016, Celebrating Biotechnology: Destination India” organized by DBT, Govt. of India at Vigyan Bhavan, New Delhi on February 5-6, 2016. 10. Orientation Program (OP-112) organized by University Grants Commission, HRDC at University of Calcutta, Kolkata from December 1-30, 2015. 11. "Workshop on fundamentals of mass spectrometry for beginners" at Institute of Bioinformatics (IOB), Bangalore from October 07-09, 2015. 12. Microscope Workshop “Celltember” organized by GE Health care at Translational Health Science and Technology Institute (THSTI), Faridabad from September 23-24, 2015. 13. Served as a ‘Session Chair’ on 4th Annual conference of Molecular Pathology Association of India (MPAI), held at Novotel, Kolkata organized by Tata Medical Centre, Kolkata on February 14-15, 2015 Curriculum Vitae 4 Abhik Saha

14. National symposium on "Environmental Impact on Biodiversity and Plant Development" held on February 19 - 20, 2015 at Presidency University, Kolkata. 15. Public lecture by Ruchira Gupta on “As if Women Matter:Feminism Beyond Borders to Tackle Sex Trafficking” on February 19, 2015 at Presidency University, Kolkata. 16. Public lecture by Prof. Mriganka Sur, MIT, Boston on “Brain wiring and brain disorders” on January 13, 2015 at presidency University, Kolkata. 17. Public lecture by Prof. Abha Sur, MIT, Boston on “Recasting Science” on January 13, 2015 at presidency University, Kolkata. 18. Public lecture by Prof. Inder Verma, Salk Institute of Biological Sciences, California on “Cancer Stem Cells: Hierarchy Vs. Plasticity” on January 5, 2015 at presidency University, Kolkata. 19. Public lecture by Prof. S. R. Kulkarni, California Institute of Technology on “Astronomy on the Cusp: A Subject Driven by Progress in Technology” on January 5, 2015 at presidency University, Kolkata. 20. ‘2nd Ramanujan Conclave’, December 13-14, 2013, held at Pune, Jointly organized by DST, Govt. of India and IISER, Pune. 21. ‘10th Annual Symposium on Herpesviruses’, June 9, 2010, held at University of Pennsylvania School of Medicine, Philadelphia, PA, USA. 22. ‘The Henle Symposium’, organized by the Abramson Cancer Center Tumor Virology Program and the Department of Microbiology of University of Pennsylvania, September 22, 2008. 23. FAOBMB Satellite Symposium on “Regulation on gene expression” Dec. 5-6, 2003, held at Indian Institute of Chemical Biology (IICB), Kolkata, India, organized by Society of Biological Chemists, Kolkata, INDIA. 24. Workshop on “Modeling of Protein Structures and Interactions”, Feb. 27-28, 2002, held at Bose Institute, Kolkata, India, organized by Bioinformatics, Bose Institute, Calcutta, INDIA and funded by Dept. of Biotechnology, New Delhi, INDIA.

Invited or selected speaker: 1. Saha A. “Tumor Viruses: a tool to understand Cancer Biology" at Dept. of Microbiology, St. Xavier’s College, Kolkata on August 24, 2016. 2. Saha A. “Viruses and Human Cancers” at Orientation Program (OP-112) organized by University Grants Commission, HRDC at University of Calcutta, Kolkata on December 27, 2015. 3. Saha A. “Human tumor virus: a clue to dissect cancer biology” at the first joint meeting between Tata Medical Centre (TMC/TTCRC), Kolkata and Presidency University, Kolkata at TMC, Kolkata on November 14, 2015. 4. Saha A. “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach” at Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Mumbai, 2012. 5. Saha A. “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach” at National Center for Cell and Science (NCCS), Pune, 2012 6. Saha A. “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach” at National Institute of Immunology (NII), New Delhi, India, 2012. 7. Saha A. “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach” at Regional Centre for Biotechnology (RCB), Gurgaon, India, 2012. 8. Saha A. “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach” at Indian Institute of Chemical Biology (IICB), Kolkata, India, 2012. 9. Saha A. “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach” at Chittaranjan National Cancer Institute (CNCI), Kolkata, India, 2012. 10. Saha A. “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach” at Indian Institute of Science Education and Research, Bhopal (IISER-B), India, 2012. 11. Saha A. “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach” at Bose Institute, Kolkata, India, 2011. 12. Saha A. “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach” at Indian Institute of Science Education and Research, Kolkata (IISER-K), India, 2011. 13. Saha A, Robertson ES. “EBV Essential Antigen EBNA3C Blocks DNA Damage Induced E2F1 Mediated Apoptosis” on December 16, 2011 organized by Abramson Cancer Center ‘Tumor Virology Program’ and the Department of Microbiology of University of Pennsylvania. 14. Saha A, Robertson ES. “EBNA3C Facilitates G1-S Transition by Stabilizing and Enhancing the Function of Cyclin D1” on August 29, 2010 organized by Abramson Cancer Center ‘Tumor Virology Program’ and the Department of Microbiology of University of Pennsylvania. 15. Saha A, Robertson ES. “Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and Curriculum Vitae 5 Abhik Saha

degradation by deubiquitinating Mdm2” on August 23, 2009 organized by Abramson Cancer Center ‘Tumor Virology Program’ and the Department of Microbiology of University of Pennsylvania. 16. Saha A, Murakami M, Kumar P, Robertson ES. “Epstein Barr Virus Nuclear Antigen 3C Augments Mdm2- Mediated p53 Ubiquitination and Degradation by Deubiquitinating Mdm2” in ‘9th Annual Herpesvirus Symposium’ held at University of Pennsylvania School of Medicine, Philadelphia, PA, USA on June 15, 2009. 17. Sharma A, Saha A, Bhattacharjee S, Majumdar S, DasGupta SK. “Peptide mimotopes of TB antigens-novel tools for diagnosis and immunotherapeutics” in the symposium on ‘Recent Developments in Modern Biology’, May 19-21, 2006, held at Digha, INDIA, organized by Society of Biological Chemists, Calcutta, INDIA. 18. Saha A, Sharma A, Dhar A, Bhattacharya B, Roy S, DasGupta SK. “Peptide inhibitors of Hsp16.3, a small molecular weight mycobacterial chaperone and virulence factor” in One-day symposium on ‘Excitements in Modern Biology’, Sep. 24, 2005, held at Dept. of Biochemistry, Calcutta University, Kolkata, India, organized by Society of Biological Chemists, Kolkata, INDIA.

Meetings/Seminars/Conferences Organized: 1. Seminar by Prof. Usha Menon, University of College London, UK on “Ovarian cancer screening: the long journey” on March 30, 2016 in weekly departmental colloquium at Presidency University, Kolkata. 2. Seminar by Dr. Sangram Bagh, Saha Institute of Nuclear Physics, Kolkata on "Can we program a cell like an engineer programs a device?: Synthetic biology and its application in cellular robotics, programmed therapeutics and space travel" on March 2, 2016 in weekly departmental colloquium at Presidency University, Kolkata. 3. One-day symposium “Life Sciences Symposium” jointly sponsored by Wellcome Trust/ DBT India Alliance and Presidency University, Kolkata at Presidency University, Kolkata on February 23, 2016. 4. ‘By monthly’ meeting for "Kolkata Cancer Research Cluster" involving TTCRC/TMC, Presidency University, Bose Institute, NIBMG and TCG Life Sciences (TCGS) at Presidency University, Kolkata on January 27, 2016. 5. Seminar by Dr. Shubhankar Chatterjee, Central University of Himachal Pradesh on "Biological significance of microbe-microbe interactions: Metabolomics approach" on January 6, 2016 in weekly departmental colloquium at Presidency University, Kolkata. 6. Seminar by Prof. Suman Dhar, Jawaharlal Nehru University, New Delhi on "A Multidisciplinary approach to understand and inhibit DNA replication in human malaria parasite Plasmodium falciparum" on February 3, 2015. 7. National symposium on ‘Molecules to Systems’ at Presidency University from January 29 – 31, 2015, Sponsored by DBT-BUILDER program at Presidency University. 8. Seminar by Prof. Ranjan Sen, Center for DNA Fingerprinting and Diagnostics, Hyderabad, on "Regulations of Rho-dependent transcription termination in bacteria" on January 16, 2015.

Awards and recognition: A) National (list): 1. 2015 – Awarded ‘Wellcome Trust/DBT India Alliance Intermediate Fellowship’ by Department of Science & Technology, Government of India. 2. 2014 – Selected as Young Investigator at ‘Young Investigator Meeting, 2014’, organized by India BioScience and NCBS, Bangalore. 3. 2012 - Awarded ‘Ramanujan Fellowship’ by Department of Science & Technology, Government of India. 4. 2012 - Awarded ‘Senior Research Associateship’ (Scientists’ Pool Scheme) by Council of Scientific and Industrial Research (CSIR), Human Resource Development Group, Government of India. 5. 2001-2003 - Awarded ‘Junior Research Fellowship’ in a New Millennium Indian Technology Leadership Initiative (NMITLI) - CSIR, India sponsored project under the guidance of Dr. Sujoy K. DasGupta. 6. 2003-2006 - Awarded ‘Senior Research Fellowship’ in a New Millennium Indian Technology Leadership Initiative (NMITLI) - CSIR, India sponsored project under the guidance of Dr. Sujoy K. DasGupta. 7. 2005 - Awarded first prize in Poster presentation in the International Conference on ‘Functional Genomics for Novel Vaccine and Drug Design against Mycobacterial Infection (VDMI)’, held at Indian Institute of Technology (IIT), Kharagpur, India, jointly organized by Dept. of Biotechnology, IIT, Kharagpur, INDIA and University of Bergen, Bergen, Norway. 8. 2000 - Qualified Graduate Aptitude Test in Engineering (GATE), organized by Indian Institute of Technology (IIT), Kharagpur, Department of Education, and Ministry of Human Resources Development Government of India, with 93.96 Percentile score. All India Rank: 126.

B) International (list):

Curriculum Vitae 6 Abhik Saha

1. 2017 – Travel Award for “Early Career Scientists” by Royal Society, London, UK to attend the ‘Commonwealth Science Conference 2017’ at Singapore on June 13-16, 2017. 2. 2016 – Selected for ‘Poster Presentation’ in 17th international Symposium on EBV and associated diseases – Zurich, Switzerland, to be held on August 8-12, 2016. 3. 2016 – Selected for ‘Poster Presentation’ in 1st DELTAS Annual Meeting, Nairobi, Kenya, Africa to be held on July 5-6, 2016. 4. 2016 – Selected for ‘Poster Presentation’ in a two-day meeting on “Epidemiological Transition” at Nairobi, Kenya, Africa, jointly organized by The African Academy of Sciences and the Royal Society of Tropical Medicine and Hygiene to be held on July 7-8, 2016. 5. 2009 - Selected for ‘Oral Presentation’ in ‘9th Annual Herpesvirus Symposium’ held at University of Pennsylvania School of Medicine, Philadelphia, PA, USA. 6. 2008 - Selected for ‘Poster Presentation’ in ‘34th Annual International Herpesvirus Workshop’, held at Cornell University, Ithaca, NY, USA. 7. 2007 - Awarded ‘Post Doctoral Fellowship’ at University of Pennsylvania, USA in a National Institutes of Health (NIH) sponsored project.

Synergistic Activities:  Teaching: M.Sc Biotechnology and Biological Sciences - Molecular Biology, Genetics, Recombinant DNA Technology, Microbiology and Genomics theory and lab sessions since November 1, 2012.  Outreach: Invited Paper-Setter, Examiner, Moderator, External evaluator of M.Sc curriculum in various College/Universities - Presidency University, Tripura University, and St. Xavier’s College).  Centre-in-Charge: M.Sc Biotechnology Examinations 2012-2013 at Presidency University, Kolkata  Convener: 2014-15, ‘Integrative Biology’ PhD Committee, Dept. of Biological Sciences, Presidency University, Kolkata.  Member: Departmental PhD Committee and Institutional Biosafety Committee (IBSC), Department of Biological Sciences, Presidency University, Kolkata.  Joint Coordinator: DBT-BUILDER program for establishment of Central Instrumentation Research Facility (2014-15).  Invited Peer Reviewer: Future Microbiology; Infectious Agents and Cancer.  Member of Professional Societies: Society of Biological Chemists, India and The American Society for Microbiology.

Training Students/Scholars:  2014- : Ms. Shaoni Bhattacharjee, DST INSPIRE Fellow, working as PhD Scholar.  2013-16: Ms. Sryeshi Chandra, BSc, Biological Sciences. Selected for PhD program at National Brain Research Centre (NBRC), Manesar, Haryana, INDIA.  2015-16: Trained two Biological Sciences MSc. students Mr. Syamantak Ghosh and Ms. Oindrila Som as a part of their course curriculum for one whole semester (6-months). They are still working in my lab as trainees and preparing for competitive exams.  2014-15: Trained two Biological Sciences MSc. students Mr. Shatadru Ghosh Roy and Ms. Priyanka Bose as a part of their course curriculum for one whole semester (6-months). Later they have joined as project fellows in my lab.  2013-14: Trained three MSc. Biotechnology students Ms. Arifa Akbar, Ms. Koyeli Das and Ms. Pratiti Nath as a part of their course curriculum.  2012-13: Trained three MSc. Biotechnology students Ms. Poulami Tapadar, Mr. Sayantan Joardar and Ms. Wahida Rahman as a part of their course curriculum. Both Poulami and Wahida are PhD scholars at Presidency University, Kolkata. Poulami received DST-INSPIRE fellowship.  2011-12: Ms. Lise Morizur was one of the best summer trainees worked with me during my postdoctoral tenure at University of Pennsylvania, USA and eventually she was authored in one of my work published in PloS Pathogens, 2012.  2001-2007: Trained several summer-trainees, JRFs during PhD-tenure at Bose Institute, Kolkata

Research Grant/Extramural Support:  Principal Investigator: Wellcome Trust/DBT IA Intermediated fellowship sponsored project entitled “Understanding the Molecular Crosstalk between Unfolded Protein Response and EBV pathogenesis in Curriculum Vitae 7 Abhik Saha

developing B-cell Lymphomas”. Total amount: Rs. 3,58,38,792.00 (5 years; 2015-2020).  Principal Investigator: Department of Biotechnology (DBT), Govt. of India sponsored project entitled “Targeting Autophagy- Apoptosis Network as a Potential Therapeutic Strategy against Chronic Myeloid Leukemia”. Total amount: Rs. 61,43,000.00 (3 years; 2013-2016).  Principal Investigator: Ramanujan Fellowship, Department of Science & Technology (DST), Govt. of India sponsored project entitled “Targeting Apoptosis-Autophagy Network in Virus Associated Human Cancers – A Therapeutic Approach”. Total amount: Rs. 86,00,000.00 (5 years; 2013-2018). Relinquished on July 2015 due to acceptance of Wellcome Trust/DBT IA Intermediate fellowship.  Principal Investigator: Department of Biotechnology (DBT), Govt. of India sponsored project entitled "Support to establish DBT- Boost to Presidency University Interdisciplinary Life science Departments for Education and Research (BUILDER) program". Total amount: Rs. 4,94,85,767.00 (1 year; 2014-2015).

Curriculum Vitae 8