MARCH 21 • 2014 PUBLISHED FOR THE USC HEALTH SCIENCES CAMPUS COMMUNITY VOLUME 1 • NUMBER 6

Symposium Lasker Lecturers shed light on major breakthroughs highlights By Amy E. Hamaker Keck School of Medicine key stem cell of USC students and faculty gathered to learn more about advances genetic cancer therapy and neurotransmitter release in the By Ellin Kavanagh brain at the 2014 Lasker Lec- and Cristy Lytal tures Program, held on March USC stem cell 4 at Mayer Auditorium. researchers discussed Richard H. Scheller, PhD, the promise of executive vice president, regenerative medicine research and early develop- Steve Cohn Steve and cellular therapies ment at Genentech, and Lasker Lecturers Thomas C. Südhof (left) and Richard H. Scheller (center) speak with Keck School of Medicine — from curing HIV to Thomas C. Südhof, MD, Dean Carmen A. Puliafito at the Keck School on March 4. building organs such as Avram Goldstein Professor kidneys and intestines and professor of molecular the public and advocating for medical center has hosted flatlined for the last 10 years, — at The Saban and cellular physiology at support of medical research. both the Albert Lasker Basic resulting in a 25 percent loss in Research Institute of Stanford University School of Its awards program recognizes Medical Research and Clini- purchasing power,” she said. Children’s Hospital Medicine, were co-winners contributions of those who cal Award recipients.” (The “We’re thrilled that the Lasker Los Angeles Annual of the 2013 Albert Lasker have made major advances in clinical award recipients will Foundation and Keck School Symposium, held on Basic Medical Research the understanding, diagnosis, speak at the Health Sciences of Medicine are collaborating Feb. 21. Award for their work over the treatment, cure or prevention Campus on April 10.) on this very special event.” The panel of course of two decades on the of human disease. Increasing awareness of Scheller’s lecture, “The speakers included mechanisms that underlie “We’re here today for a research translation is vital War on Cancer 2014,” fo- investigators from USC, neurotransmitter release. celebration of science,” said in today’s funding climate, cused on gene mutations that Children’s Hospital The Lasker Founda- Keck School Dean Carmen added Clair Pomeroy, MD, have been found to initiate Los Angeles (CHLA), tion’s mission is to foster the A. Puliafito, MD, MBA, who MBA, president of the or increase tumor growth, Children’s Hospital prevention and treatment of welcomed attendees. “This is Albert and Mary Lasker and the promising regulators of Philadelphia, the disease and disabilities by the first time in the history of Foundation, during her and inhibitors that are being University of Colorado honoring excellence in basic the Albert and Mary Lasker welcoming remarks. tested to impede that growth. and City of Hope. and clinical science, educating Foundation that an academic “The NIH budget has See LASKER, page 2 Several of the presenters are also participants in USC Stem Cell, Ron Smith, former chair of the Department of Ophthalmology, 71 a collaborative, multidisciplinary By Sara Reeve ophthalmology,” said Keck awards for his achievements, initiative working to Ronald E. Smith, MD, for- School Dean Carmen A. including a prestigious Gold translate the potential of mer chair of the Department Puliafito, MD, MBA. “He Medal from the Internation- stem cell research to the of Ophthalmology at the was a pioneering researcher, al Uveitis Study Group. clinical imperative of Keck School of Medicine a compassionate clinician “The world has lost an regenerative medicine. of USC, died on Monday, and an inspiring leader. He international innovator in eye D. Brent Polk, MD, March 17. He was 71. He will be missed.” care and research,” said Tom director of The Saban led the department from He had gained inter- Jackiewicz, MPH, senior Research Institute and 1995 until retiring in 2013, national prominence in vice president and CEO for chair of pediatrics at the and was one of the founding his field and was a former USC Health. “The founda- Keck School of Medi- members of the department, president of the American tion Ron Smith helped to cine of USC, welcomed having joined USC in 1975. Academy of Ophthalmol- establish here at USC lives speakers and guests. “Ron Smith helped ogy and former chair of the on through a lasting legacy “This is an exciting establish USC as a local American Board of Ophthal- of research, clinical innova- Ron Smith, former chair of the and fast-moving field,” and national powerhouse in mology. Smith earned many See SMITH, page 4 Department of Ophthalmology he said, “where the promise of lifesaving stem cell therapy, organ regeneration and tissue engineering are quickly becoming a reality.” Andrew McMahon, PhD, keynote speaker and head of USC Stem Cell, announced a call for proposals for free small molecule screens, which allow researchers to test the effectiveness of 3,000 potential drugs to treat various diseases. Pluth Photos/Kim HELPING HANDS FOR SORE BODIES — More than 180 volunteers from The screenings will take the Keck School of Medicine Department of Emergency Medicine — led by place at The Choi Family Sean O. Henderson, chair of the department, and department physicians Therapeutic Screening Clare Roepke and Dhara Amin — turned out to offer aid at the LA Marathon Facility, located at the Eli on March 9. Medical personnel and volunteers assisted more than 2,000 and Edythe Broad CIRM runners for various ailments along the 26.2-mile route. Left, Ramin Tabatabai, Center for Regenerative assistant clinical professor of emergency medicine, helps a runner in distress Medicine and Stem Cell at the finish line medical tent. Above left, Glenn Ault, LA Marathon Medical Research at USC. Commissioner and associate professor of clinical surgery at the Keck School, is See STEM CELL, page 4 interviewed by KTLA about the medical service provided by the USC physicians and nurses. Above right, racers walk away from the finish line. MARCH 21 • 2014 Keck School holds steady in U.S. News & World Report ranking

By Sherri Snelling crease from 34th in the 2013 rankings. school was among the first medical schools across America. U.S. News & World Report released “The Keck School is proud to be schools to adopt “Introduction to USC’s Division of Biokinesiology its annual “Best Graduate Schools in the top 20 percent of nationally Clinical Medicine” courses for first- and Physical Therapy and Division of Guidebook 2015” today showing the ranked medical schools thanks to the year students to give them real-world Occupational Therapy were ranked Keck School of Medicine of USC ranks focus and contributions of our faculty, experience in patient care from the No. 1 in the last ranking for those 31st in research among 153 medical staff and students,” said Carmen A. start of medical school. The school is disciplines, which took place in 2012. schools nationwide. The new rankings Puliafito, MD, MBA, dean of the also home to Health, Technology and Both divisions are housed within the appear online and will be published in Keck School of Medicine. “I attribute Education (HTE@USC), an innova- Ostrow School of Dentistry of USC. the guidebook available in April. this recognition to our recruitment of tive educational program developed The USC School of Pharmacy was Founded in 1885, the Keck School is transformative clinician researchers in 2010 that facilitates cross-disci- ranked 10th. the oldest medical school in Southern and innovative administrators and plinary education for medical and The health rankings in physical California, and is part of Keck Medi- staff. This ranking underscores our engineering students to work jointly therapy, occupational therapy and cine of USC, one of the nation’s leading position as one of the best American on solutions to health care problems. pharmacy are based solely on the re- academic medical centers. This year’s medical schools in research.” In 1970, the Keck School led the sults of peer assessment surveys sent ranking remains steady at 31, the same The Keck School is a national movement toward the use of the to deans, other administrators and/or ranking the Keck School of Medicine leader in medical education with an “standardized patient” for medical faculty at accredited degree programs held in the 2014 rankings and an in- integrated hands-on curriculum. The training, an idea that has taken root at or schools in each discipline. David Berman, distinguished emeritus professor, pharmacology teacher, 96

By Amy E. Hamaker his PhD in Pharmacology cology to first- and second- keeps you young — you David A. Berman, PhD, at USC. He joined USC’s year students by being pick up on their energy a distinguished emeri- faculty in 1952, receiv- rehired annually — hence and excitement,” he said, tus professor of cell and ing more than 45 teaching his “emeritus” designation. in a Keck Medicine magazine neurobiology at the Keck awards during his tenure. He officially retired in June article in January 2012. School of Medicine of USC He also sponsored several 2012. “It has always been a and a fixture on the USC curriculum additions, includ- The David A. Berman special moment when a Health Sciences Campus ing “Medicine in History, Pharmacology Achievement student would come to me, for 60 years, passed away Literature and Art.” Award was established in introduce him or herself and on Saturday, March 8. He When Berman turned 70 his honor in 1997, and is say, ‘My mom or dad was in was 96. during the 1980s, USC fac- presented annually to an your class.’” Berman earned his bach- ulty members were required outstanding pharmacology Berman is survived by his elor’s degree and master’s to retire. Berman was able to student. wife Miriam, two daughters degree in Pharmacy and continue teaching pharma- “Being with students David A. Berman and three grandchildren.

HOSPITALS ARE GOOD LASKER: Pioneering NEIGHBORS — Keck Hospital of USC and USC Norris Cancer Hospital proved they’re good research in bioscience neighbors in the Los Angeles community by matching funds Continued from Page 1 raised in the 2013 USC Good For example, according to Scheller, 40 to 60 percent of melanoma Neighbors Campaign. Hospital patients have a BRAF V600 gene mutation; BRAF mutations employees raised $106,000 — an stimulate cell growth. Scheller cited research showing that the drug increase of 33 percent over 2012 — vemurafenib inhibits tumor growth. “We also found that adding a and the hospitals gave a matching Mek inhibitor [chemicals or drugs that inhibit certain enzymes along gift of $100,000. Pictured, Sanjit signaling pathways] partway through treatment increased the dura- Mahanti, executive administrator, tion of tumor inhibition by two to three times,” he said. hospital performance, presents Scheller also described some gene mutations in metastatic an oversized check to Craig Keys, disease that are extremely difficult to treat. “In the genomic associate senior vice president for civic engagement, and Tom Sayles, landscape of somatic mutations in a lung tumor, we found that there senior vice president for university were over 50,000 point mutations and over 20 major genome rear- relations, during a USC basketball rangements,” Scheller said. “We wondered, why doesn’t the immune game on Feb. 27 at the Galen system recognize these cells as mutant and attack them? The answer Center. is that although T cells are programmed to find tumors, the tumor John McGillen itself turns off the T cell’s response. We’ve only recently begun to understand the mechanisms whereby this takes place.” Scheller described research that targets these tumors with the protein Anti-PD-L1, which inhibits tumor response so that the T cells can perform their functions. HSC News Next Issue: April 4 Südhof’s lecture, “The Mechanism of Neurotransmitter Release,” focused on the basic mechanisms that he and his team discovered about how neurotransmitter release between synapses happens that HSC News is published for the faculty, staff, students, volunteers and visitors in the University resulted in his Lasker Award. (Südhof also received the 2013 Nobel of Southern California’s Health Sciences Campus community. It is written and produced by the Prize in Physiology or Medicine for discoveries of machinery regulat- Health Sciences Public Relations and Marketing staff. Permission to reprint articles is available ing vesicle traffic.) upon request. No artwork may be reproduced without the artist’s consent. Neurotransmitters are chemicals that transmit signals across a synapse between neurons. “Twenty-five years ago, not a single Associate Vice President, Health Sciences Public Relations and Marketing: synapse component had been molecularly described,” said Südhof. Deborah S. Fullerton “Today we understand the structure and know how the machinery Executive Director of Creative Services: Tom DeSanto works. This is work at a very fundamental level of biology.” Synapses are the fundamental computational units of the brain, Assistant Director of Publications: Sara Reeve Südhof explained, and although synapses differ in properties, all synapses operate by the same principle: An action potential invades Editor: Jon Nalick the presynaptic nerve terminal, an influx of presynaptic calcium ions Contributors: Amy E. Hamaker, Ellin Kavanagh, Kim Pluth, Leslie Ridgeway, Sherri Snelling triggers neurotransmitter release, and then those neurotransmitters and Alison Trinidad bind to postsynaptic receptors and provoke an electrical signal. Synaptic transmission happens extremely quickly, said Südhof. Vice President, Public Relations and Marketing: Brenda Maceo “Three processes enable this speed: synaptic vesicle fusion, the triggering of that fusion through calcium and the fact that the Phone: (323) 442-2830 Fax: (323) 442-2832 calcium influx is localized right next to vesicles that are ready to Email: [email protected] Web: theweekly.usc.edu fuse — any distance between the calcium channel and the vesicle release sites would result in neurotransmitter release blockage.” $500,000 gift supports research to discover why powerful cancer drugs fail

By Sara Reeve ally, and we study why it fails — the to raise awareness nationwide and fund In a lab in the USC Norris pathways that allow the cancer cells research that can lead to breakthroughs Comprehensive Cancer Center, to circumvent it,” said Ladner at the in childhood cancer treatment. Anthony El-Khoueiry, MD, director dedication of his lab in honor of Moore “We see a lot of children struggling of the Phase 1 Drug Development for Kids, held on Feb. 7. “We identi- with cancer, and we see the work Program at USC Norris, told a crowd fied a key resistance mechanism, an that these scientists are doing — it’s of donors and scientists one simple enzyme called dUTPase, and that’s just something we’re meant to be fact: “With the right support, things what we’ve been trying to inhibit.” part of,” said Robert Moore at a can move very fast.” Ladner told attendees he has dedi- reception following the dedication In this instance, the right support cated much of his research career to this of the Ladner lab. “We’re pleased is a $500,000 gift from the Moore for effort, and that it is only now that this that we could do this with USC and Kids Foundation, and the things that hard work is beginning to pay off. “What Dr. Ladner. We just can’t say enough can move fast are the research efforts we’ve achieved in the last 12 months about the work he’s doing. There are of Robert Ladner, PhD, assistant has been more than we achieved in the children we know who are fighting professor of pathology at the Keck previous 10 years,” he said. the good fight, but they need these School of Medicine of USC. Ladner’s Flanked by Niki and C. L. Max Nikias, philan- Buffalo, N.Y.-based Moore for Kids, scientists to do what they do, and we lab studies how and why the common thropist Robert Moore (center) appears at a founded by philanthropists Kristi and wanted to play our part. Our goal is to chemotherapy agent fluoropyrimidine recent USC women’s basketball game to show Robert Moore, supports work to ease raise an additional $500,000 for USC support for the research of Robert Ladner. 5-fluorouracil (5-FU) fails in some the suffering of children due to illness Norris.” patients undergoing treatment, and and adversity. Their recent gift to USC Moore for Kids is a 501c(3) orga- whether new therapeutic agents can “We take the drug 5-FU, which Norris is the first in their new program, nization and is dedicated to raising stop that failure. we know fails in everybody eventu- the Torpedo Project, the aim of which is awareness for the goodness of giving. Annual Scholarship Gala raises record amount for medical scholarships

By Amy E. Hamaker location at the Jonathan Club. music from the 1960s. The weather was a balmy Special guest Andrew Or- The gala had the largest 80 degrees at Town & Gown don, MD (’79), best known number of individual spon- of USC on the evening of as a co-host of the Emmy sorships of any previous gala, March 8 — a lovely setting award-winning syndicated and raised nearly $325,000 to celebrate and raise funds talk show The Doctors, served — almost quadrupling previ- for medical scholarship at as the event’s emcee. A ous raised amounts. Funds USC at the Keck Scholar- cocktail reception was held will help support medical ship Gala. in Town & Gown’s court- scholarships. More than 250 people at- yard and foyer, while guests Along with the Keck tended the event, co-produced strolled among silent auction Medical Center of USC, the by the Salerni Collegium tables. USC Institute of Urology Cohn Photography Steve Santop/ Ziva From left at the gala are: Lisa Lerner; Gala Committee Chairs Carmel Alumni Association, and by During the event, 20 and the USC Office of Di- Gardner and Donna Ford; and Sylvia Kast. Medical Faculty, Friends & Keck School students were versity, several Keck School Family, which is celebrating awarded with their medical departments sponsored the • Medicine • Radiology its 70th anniversary this year. scholarships and featured in event, including: • Neurology • Surgery This was the first year that a celebratory video. Musi- • Anesthesiology • Obstetrics and Gynecology Funds raised will help to the gala was held at Town & cal group Walk Like a Man • Emergency Medicine • Orthopaedics support medical scholarships Gown, rather than its previous inspired dancing with classic • Family Medicine • Otolaryngology for Keck School students. Frank Jobe, Keck School physician, inventor of surgery, 88

Frank Jobe, MD, a clinical professor of elbow, connecting the humerus to the ulna. It his long career, serving as the medical director for orthopaedics at the Keck School of Medicine of can be injured through repetitive stress or from the PGA Tour & Senior PGA Tour, and consulting USC who was best known as the originator of trauma. Jobe transplanted a tendon from John’s with the , Los Angeles Tommy John elbow surgery that helped preserve right wrist to his left elbow. Following surgery Kings and of Anaheim. The the careers of a number of Major League and recovery, John went on to have a successful Hall of Fame honored Jobe during a Baseball pitchers, passed away on March 7. He pitching career. ceremony in July 2013 for his contributions to was 88. Jobe also developed a shoulder repair procedure the sport. During his time as an orthopaedic specialist with that produced less trauma to tissue, which he “Frank Jobe was an inspiration to all doctors the , Jobe first performed ulnar performed for the first time on Dodgers pitcher and for his commitment to orthopaedic medicine and collateral ligament (UCL) reconstruction on pitcher Cy Young Award winner . his innovative techniques for helping professional Tommy John, who was injured during a game Jobe received his medical degree from Loma athletes recover from previously devastating injury,” against the Montreal Expos in 1974. Previously, Linda University, and performed his internship and said Carmen A. Puliafito, MD, MBA, dean of the this surgery had been performed on polio patients residency in orthopaedics at LAC+USC Medical Keck School of Medicine. “His techniques will to improve mobility, but had not been tried on Center. He became the Dodgers’ orthopaedic doctor continue to serve as inspiration for generations of athletes. in 1968. surgeons to follow.” The UCL is located on the inside of the Jobe continued his work with athletes during See JOBE, page 4 MARCH 21 • 2014

JOBE: Physician pioneered key orthopaedic techniques in sports medicine

Continued from page 3 Society for Sports Medicine, Orthopaedic Surgery, said In a 2008 photo, Frank Jobe, Jobe was also the founder president and secretary of Jobe “was not only a superb a former clinical professor and medical director of the the clinician but he was men- of orthopaedics at the Keck Biomechanics Laboratory at Physicians Association, tor to many of the leaders School of Medicine of USC and the pioneer of Tommy Centinela Hospital Medical and program director of in sports medicine today. John elbow restoration Center in Los Angeles, and the Western Orthopedic Our hope is that one day he surgery, watches a Los co-founder of the Kerlan- Association. will be inducted into the Angeles Dodgers vs. San Jobe Orthopaedic Clinic. Jay Lieberman, MD, Baseball Hall of Fame in Diego Padres game at He served as chairman of professor and chair of the recognition of his contribu- Dodger Stadium in Los the American Orthopedic Keck School Department of tions to baseball.” Angeles. LA Dodgers Jon Soo Hoo/

SMITH: Contributions to ophthalmology will live on

Calendar of Events Continued from page 1 Native Medical Center in Anchorage. tion and education that have touched so many He practiced at USC for more than three other leaders in this field. His contributions to decades, where he pursued his longstand- Wednesday, March 26 4:30 p.m. Jane Anne Nohl Division of Hematology medicine will live on.” ing clinical and research interests in external Noon. The Saban Research and Center for the Study Smith graduated from Johns Hopkins disease, cornea and uveitis. Institute Seminar Series of Blood Diseases Lecture. University School of Medicine in 1967. After “During his term as chair, Smith led the Seminar. “Novel Insights “Genetic Modification completing his residency at the Wilmer Eye department to new heights,” said Rohit in Transcriptome and of T Cell for Cancer Institute at Johns Hopkins, he completed Varma, MD, MPH, chair of the Department of Metabolic Remodeling of Immunotherapy,” Stanley a fellowship in uveitis, cornea and external Ophthalmology and director of the USC Eye Failing Hearts,” Yibin Wang, R. Riddell, University of UCLA. Saban Research Washington. Harlyne J. disease at the Francis I. Proctor Foundation Institute. “He helped make the department Building, First Floor Norris Cancer Research for Research in Ophthalmology, University of one of the top 10 departments of ophthalmol- Auditorium, CHLA. Info: Tower, LG-503/504. Info: California Medical Center at San Francisco. ogy in the United States, and it grew in its Cathy Bergren, (323) 865- Harleen Gill, (323) 361- He returned to Wilmer as chief resident, fol- research programs, clinical care and educa- 8626, [email protected] 3913, [email protected] lowed by two years in the U.S. Public Health tional endeavors. His loss leaves a huge hole Noon – 2 p.m. Center for Friday, March 28 Service as an ophthalmologist for the Alaska in our hearts and in our lives.” Excellence in Research Seminar. “NIH Grants: Noon. Jane Anne Nohl STEM CELL: Symposium highlights innovative research Strategies to Get Funded,” Division of Hematology and Silvia da Costa, USC. NML Center for the Study of Blood West Conference Room. Diseases Lecture. “Cancer Continued from page 1 Paula Cannon, PhD, asso- cardiac vasculature and heart Info: research.usc.edu/for- and the Immune System at McMahon also shared his ciate professor of molecular regeneration after injury. investigators/training the Threshold — Again,” research about the genera- microbiology, pediatrics, and The event featured a pre- Stanley R. Riddell, University tion and regeneration of the biochemistry & molecular sentation of CHLA’s Pasa- of Washington. LAC+USC Thursday, March 27 kidney and its promise for Medical Center, IPT, C2J104, biology at the Keck School dena Guild Endowed Chair preventing chronic kidney and part of The Saban in Developmental Biology 9 a.m. – 4 p.m. KSOM Dept. of Conference Room B, 1200 N. Radiology, HTE@USC, Viterbi State St., Los Angeles. Info: disease, a condition that Institute, offered additional and Regenerative Medicine Information Technology Cathy Bergren, (323) 865- affects one in 10 adults in research results, including to David Warburton, DSc, Symposium. “Integrating 3913, [email protected] the United States. As a key gene therapy that could po- director of the Developmen- Advances in Imaging & member of the USC Stem tentially confer immunity to tal Biology and Regenerative Engineering Technologies: A Saturday, March 29 Theme-Focused Technology Cell Kidney Disease Team, HIV to patients’ blood stem Medicine program at The Collaboration,” various 7 a.m. – 5 p.m. Keck School he is collaborating with cells. Cannon noted that she Saban Research Institute, speakers, USC. Aresty of Medicine of USC Office Laura Perin, PhD, assistant will begin human clinical and professor of pediatrics Auditorium. Info and RSVP: of Continuing Medical professor of urology and trials later this year. and surgery at the Keck Education. “Diagnosis and Bhushan Desai, (213) 359- part of The Saban Research Ellen Lien, MS, PhD, School. “The future doesn’t 7015, [email protected] or Treatment of Hepatobiliary tinyurl.com/ke4wu62 and Pancreatic Neoplasms: Institute, who spoke about assistant professor of surgery just happen,” said War- State of the Art in 2014,” the therapeutic potential of at the Keck School and part burton during his keynote Noon. USC Institute for various speakers. Hilton amniotic stem cell injections of The Saban Institute, speech. “Someone has to go Global Health Lecture. “An Pasadena, 168 S. Los Robles in treating these patients. discussed her research about into the lab and invent it.” AIDS-Free Generation: Ave., Pasadena. Info: www. Scott Fraser, PhD, Provost Which Generation Might usc.edu/cme That Be?” Stephen Lewis, Professor of Biological Sci- AIDS-Free World. TCC ences, Biomedical Engineer- USC Health Sciences Monday, March 31 Public Relations and Marketing Non-Profit Organization 450. Info and RSVP: www. ing and Pediatrics at USC, 1975 Zonal Ave. KAM 400 U.S. POSTAGE PAID University of Southern California globalhealth.usc.edu/ Noon. KSOM Research and co-director of the new Los Angeles, CA 90033 stephenlewis Seminar Series Seminar. Translational Biomedical “Systems Genetics Noon. Southern California Approach to Cardiovascular Imaging Lab (TBIL) at The Research Center for ALPD and Metabolic Traits,” A. Saban Research Institute, & Cirrhosis Seminar. Jake Lusis, UCLA. Aresty spoke about the goal of “Deconstructing Pancreas Auditorium. Info: Mary TBIL: To bring together Development Using Stem Jane Chua, (323) 442-7732, Cells,” Maike Sander, [email protected]. clinicians and engineers — University of California, San edu those who know what needs Diego. McKibben Lecture to be built and those who Hall, Room 156. Info: Asma Thursday, April 3 know how to build things Deras, (323) 442-3121, [email protected] — to create innovative, 5:30 p.m. Orthopaedic image-based solutions for Surgery Grand Rounds. 4 p.m. USC Diabetes & Obesity “Recent Developments challenges in medicine and Research Institute Seminar. in Ankle Syndesmotic the basic sciences. “Proinsulin-Transferrin Fusion Injuries,”Michael J. Tracy Grikscheit, MD, Protein as a Long-Acting and Gardner, MD, Washington assistant professor of surgery at Liver-Targeted Insulin Analog,” University School Wei-Chiang Shen, USC. MCH of Medicine. Aresty the Keck School, presented her 256. Info: Christina Ayala, Auditorium. Info and RSVP: notable early success in creating (323) 442-2500, trujillc@usc. Sylvia Suarez, (323) 226- tissue-engineered human [email protected], dori.usc. 7204 [email protected] edu intestine, providing hope for premature infants and others with digestive tract problems. Notice: Calendar submissions must be received at least 10 days before an issue’s publication date to be considered. Please note that timely submission does In case of an emergency... not guarantee an item will be printed. Entries must include day, date, time, title of talk, first and last name Call the Emergency Information Phone: (213) 740-9233 The emergency telephone system can of speaker, affiliation of speaker, location and a phone handle 1,400 simultaneous calls. It also has a backup system on the East Coast. number or email address for information. Visit the USC Web: http://emergency.usc.edu This page will be activated in case of an emergen- Submit calendar items at tinyurl.com/calendar-hsc. cy. Backup Web servers on the East Coast will function if the USC servers are incapacitated.