Nucleic Acids Research

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R.T.Walker, Birmningham, UK M.J.Gait, Cambridge, UK R.B.Hallick, Tucson, AZ, USA R.J.Roberts, Beverly, MA, USA H.J.Gross, Wurzburg, Germany S.Linn, Berkeley, CA, USA K.Calame, New York, NY, USA R.I.Gumport, Urbana, IL, USA R.T.Simpson, Bethesda, MD, USA I.C.Eperon, Leicester, UK Editorial board

A.Bairoch, Geneva, Switzerland W.Guschlbauer, Gif-sur-Yvette, France E.Ohtsuka, Sapporo, Japan M.Beato, Marburg, Germany D.Hawley, Eugene, OR, USA M.Paule, Fort Collins, CO, USA M.Belfort, Albany, NY, USA R.T.Hay, St Andrews, UK S.E.V.Phillips, Leeds, UK A.P.Bird, Edinburgh, UK J.E.Hearst, Berkeley, CA, USA J.M.Rosen, Houston, TX, USA J.L.Bos, Utrecht, The Netherlands C.Helene, Paris, France C.W.Schmid, Davis, CA, USA H.Cedar, Jerusalem, Israel A.J.Jeffreys, Leicester, UK P.M.Sharp, Dublin, Eire D.A.Clayton, Stanford, CA, USA S.-H.Kim, Berkeley, CA, USA Y.Shimura, Kyoto, Japan A.Das, Farmington, CT, USA R.Krumlauf, London, UK D.Soll, New Haven, CT, USA M.L.DePamphilis, Nutley, NJ, USA A.Lamond, Heidelberg, Germany S.Spadari, Pavia, Italy M.P.Deutscher, Farmington, CT, USA C.J.Leaver, Oxford, UK K.Sprague, Eugene, OR, USA W.Dynan, Boulder, CO, USA D.M.J.Lilley, Dundee, UK G.Stormo, Boulder, CO, USA F.Eckstein, Gottingen, Germany J.T.Lis, Ithaca, NY, USA R.H.Symons, Adelaide, Australia J.D.Engel, Evanston, IL, USA R.Luhrmann, Marburg, Germany H.F.Tabak, Amsterdam, P.T.Englund, Baltimore, MD, USA N.C.Martin, Louisville, KY, USA 7he Netherlands D.J.Finnegan, Edinburgh, UK M.McClelland, La Jolla, CA, USA I.Tinoco, Jr, Berkeley, CA, USA D.Gallwitz, Gottingen, Germany W.R.McClure, Pittsburgh, PA, USA D.J.Weatherall, Oxford, UK M.Gellert, Bethesda, MD, USA R.McMacken, Baltimore, MD, USA A.M.Weiner, New Haven, CT, USA B.E.Griffin, London, UK M.Muramatsu, Saitama, Japan G.Zon, Foster City, CA, USA W.Gruissem, Berkeley, CA, USA J.R.Nevins, Durham, NC, USA Editorial and Production

Joy Walker, UK Editorial Office Susan Jefferies, Production Editor Carol Cook, US Editorial Office Sarah Brennan, Production Assistant, Jaqueline Grainger, Production Assistant

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Cover: The a subunit of E. coli DNA polymerase III holoenzyme completely encircles DNA. The dimer interface is present in this view over the top of the duplex. Author index 2961

Ace,C.I. 2907 Fukuhara,H. 2947 Koller,C.A. 2952 Rock,D.L. 2840 Aerne,B.L. 2948 Gao,X. 2867 Kornstadt,U. 2815 Roy,C. 2845 Arkov,A.L. 2891 Geiger,A. 2899 Korolev,S.V. 2891 Salas,M. 2861 Baader,C.D. 2948 Glasser,A.-L. 2949 Krimer,D.B. 2873 Santomenna,L.D. 2931 Beekman,J.M. 2789 Goudie,K.B. 2931 Kutish,G.F. 2940 Schaper,F. 2881 Berta,P. 2943 Goz6,C. 2943 Lalu,K. 2959 Schmid,V. 2948 Bhat,K.S. 2939 Green,M.R. 2907 Latchman,D.S. 2946 Schuchert,P. 2948 Bogdanov,A. 2853 Guig6,R. 2837 Laval,J. 2899 Sczakiel,G. 2809 Boiteux,S. 2899 Hancock,J.M. 2823 Lemaigre,F.P. 2907 Seliger,H. 2899 Brimacombe,R. 2853 Harris,L.J. 2921 LeMoullac,B. 2945 Shu,H.-H. 2951 Cammarano,P. 2942 Hauser,H. 2881 Lindstrom,K. 2959 Skoultchi,A.I. 2873 Castaing,B. 2899 Heitzler,J. 2949 Lingner,J. 2917 Sommer,S.S. 2953 Chadeneau,C. 2945 Hershko,A. 2950 Londei,P. 2942 Sor,F. 2947 Cheng,G. 2873 Hogan,M.E. 2789 Lu,Z. 2940 Stuart,K. 2951 Colberg-Poley,A.M. 2931 Homann,M. 2809 Luhrmann,R. 2815 Sussman,M.D. 2940 Coulson,J.M. 2957 Hsiao,K. 2921 Manley,J.L. 2815 Tabler,M. 2809 Creti,R. 2942 Huang,L. 2867 Melekhovets,Y.F. 2941 Tenney,D.J. 2931 Denis,M.G. 2945 Ing,N.H. 2789 Morrison,S.G. 2939 Troitsky,A.V. 2941 Desgres,J. 2949 Jacobs,H.T. 2801 Murphy,M. 2789 Tsai,M.-J. 2789 Dirheimer,G. 2949 Jayaraman,K. 2789 Nehls,P. 2899 Tzortzakaki,S. 2809 Dokudovskaya,S. 2853 Junke,N. 2853 Nuez,B. 2861 Walls,M.A. 2921 Dontsova,O. 2853 Kafri,T. 2950 O'Malley,B.W. 2789 Waterborg,J.H. 2913 Drissi,R. 2947 Kaijalainen,S. 2959 Paynton,C. 2953 Wil1,C.L. 2815 Duff,G.W. 2944 Karhunen,P.J. 2959 Poulat,F. 2943 Woppmann,A. 2815 Dutton,C.M. 2953 Keith,G. 2949 Prabhu,V.V. 2797 Yang,Z. 2831 El Adlouni,C. 2949 Keller,W. 2917 Qureshi,S.A. 2801 Zelwer,C. 2899 Engel,J.D. 2831 Kessler,D.J. 2789 Razin,A. 2950 Zendegui,J.G. 2789 Fickett,J.W. 2837 Khan,I.M. 2957 Ring,C.J.A. 2946 Zuo,P. 2815 Fix,C. 2949 Kirchhoff,S. 2881 Rinke-Appel,J. 2853 Forsburg,S.L. 2955 Kisselev,L.L. 2891 Rittner,K. 2809 Francis,S.E. 2944 Kohli,V. 2952 Robertson,A.J. 2913 Instructions to Authors

Please read these instructions carefully and follow them strictly to ensure that Chromosome assignment papers where only cytological data are presented are the review and publication of your paper is as efficient as possible. Please note not acceptable. Likewise, simple NMR assignment papers are not acceptable. that on submission all manuscripts must be accompanied by a manuscript submittal Only those that present new information not previously available from other form, a copy of which can be found at the end of these instructions. methods are considered. Manuscripts dealing with small molecule-nucleic acid interactions are considered ondy if they present substantial new information relevant SCOPE OF THE JOURNAL to nucleic acid structure. NucleicAcids Research provides rapid publication for papers on physical, chemical, Computer papers will only be considered if they describe new applications or biochemical and biological asects ofnucleic acids, and proteins involved in nucleic novel algorithms relevant to nucleic acid sequence demination or analysis. Small acid metabolism interactions. improvements in existing programs or variations of well-established algorithms will generally not be suitable. ORGANIZATION OF THE JOURNAL Manuscripts dealing with computer analysis of already published sequences will be considered if new and interesting findings emerge. Papers are listed under: Surveys & Sunmaries, Molecular Biology, Enzymology, Chemistry, Genome Structure and Mapping, Computational Biology, Structural For The Record Biology, Methods and For The Record Several areas of research are suitable for presentation in this section. (1) Sequence data: This is limited to the description of sequences of genes whose Surveys & Summaries ( - 8-10 printed ) products are relevant to nucleic acid metabolism and interactions. Suctul RNAs This section is intended to provide a format for brief reviews. The section heading and their genes are appropriate. The sequence must be complete and code for is deliberately chosen so that material not normally acceptable in a fonnal review an identified product. Flanking regions should be included in the data deposited article can be presented. where available. The Journal will not print the actual sequence but it must have Full-length papers (8 printed pages) been submitted to the Data Library as indicated by an accession number. Papers in to annotation that placed in the Molecular Biology, Enzymology, must contain information about the sequence addition the This section includes papers to database. that information Chemistry, Genome Structure and Mapping, Computational Biology, Structural has been submitted the sequence Typically might include a discussion of the broader significance of the sequence or features Biology and Methods headings. contained within it. Such information might have been gained either by For The Record (normally 1 printed page) experimentation or by computer analysis. A copy of the sequence deposited with This section contains data not appropriate for publication as a full paper but which the Data Library should be available for the referees and in the case of DNA are of use to other scientists. It is not intended for preliminary publication of sequences should be accompanied by a letter indicating that both strands have data which will eventually be published elsewhere or for information that would been sequenced with appropriate overlapping sequence runs. Sequences of be better included as parts of full-length papers. Publication of papers in this section pseudogenes are not acceptable. takes place within 6 weeks. Sequences not accompanied by a Data Library accession number will be retured to the authors. CRITERIA FOR ACCEPTANCE (2) Protein and nucleic acid sequence motifs: New motifs that represent signals in DNA or RNA will be considered. Modifications to previously described motifs Full-length papers must include a demonstration of increased utility. Protein sequence motifs are The Journal can only publish a fraction of the manuscripts it receives. For this limited to those present in the proteins relevant to nucleic acid metabolism and reason, the Editors insist that all manuscripts considered for publication must interactions. present some novel development and meet the critena of originality, timeliness, (3) Methods: This includes useful improvements on existng methods. However, significance and scientific excellence. Technical progress has greatly increased authors are advised that, due to intense competition for publication in this section, the ease of obtaining new sequence information-the Editors will consider only only those manuscripts reporting developments of the highest originality and those manuscripts in which new sequences are accompanied by complementary usefulness will be published and trivial or obvious variations on established nmehods data with relevance to genomic organization, transcription, RNA processing, are unacceptable. In all cases the method described should be in sufficient detail expression and genetic analysis; the reported sequence must shed significant new for it to be reproduced. Supplementary data may be supplied at submission to light on basic questions of structural or functional interest. Sequences of cDNAs indicate that the method has been fully tested. Descriptions of new vectors are or genes whose products are not relevant to nucleic acids are not acceptable. not acceptable. Manuscripts describing comparative sequence analysis will only be considered (4) NMR assignment data. ifthe genes are of relevance to nucleic acid metabolism or interactions and some (5) New restriction enzymes: this includes enzymes with novel specificities. new important findings must also emerge from the comparison. Manuscripts Usually isoschizomers will not be suitable, unless they differ significantly from dealing with the characterization of promoters or other regulatory elements will other known enzymes. only be considered if careful characterization of the element and significant new insights into regulatory mechanisms can be demonstrated. Sequences of genes NUMBERS & ATOMIC COORDINATES for well-studied RNAs (as well as the RNA sequences themselves) are not ACCESSION acceptable unless of unusual interest. Also, it is unnecessary and usually undesirable Authors should be aware that all new sequence information, including that which to print all the sequence. Provided that the sequence is available for the referees extends a previously determined sequence already present in the database (and and has been deposited in the databank, only those parts relevant to the discussion which already has an accession number) must be submitted to the Data Library of the results will be printed. for a new accession number. This number must be provided when submitting Methods papers are considered only if an outmanding and potentially very useful the manuscript. For details see Volume 21 (1). advance is clearly domented. Otherwis, the Editors prefer that such infomation Nucleotide sequence data reported in Nucleic Acids Research with an EMBL be included in the 'Methods' section of a paper presenting new data of interest. database accession number can be retrieved electronically from the EMBL File Such new methods can be highlighted and listed separately in the Table of Contents Server. This is a free service which can be used by anyone who has access to (see Vol. 19, issue no. 18). Except in extraordinary cases, manuscripts presenting electronic mail networks. For example, to get the sequence with the accession construction of cloning vehicles or clone banks, preparation of monoclonal number X12399, a mail message should be sent to the Internet address antibodies, or those describing routine syntheses of oligonucleotides or [email protected] including the following line: oligonucleotide analogues are not published unless accompanied by novel biological GET NUC:X12399 applications. The requested data will be returned automatically via electronic mail. More Genome mapping: for prokaryotic genomes only complete chromosome maps introductory documentation can be obtained by including the line: will be considered. For higher organisms, unless extraordinary circumstances HELP prevail, genome structure and mapping papers should introduce new technical The Journal now requires that atomic coordinates for crystal structures should advances or should describe a complete intron-exon structure for a gene relevant be deposited with a databa prior to manuscript submission. Aropriat databse to nucleic acid metabolism and interactions. are as follows. Nucleosides, nucleotides and other small molecules: Cambridge Crystallographic Data Centre (CCDC). Proteins, polypeptides etc.: Protein Data Disk submission Bank (PDB). Oligonucleotides: CCDC or PDB. For details on deposition of data Full-length papers will be automatically typeset from disk. It is important that see Volume 20 (1). the final copy of your paper is checked carefully because spelling mistakes, inconsistencies and errors will be faithfully translated into the typeset copy. 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COMMENTARIES Positional cloning uncovers a new old oncogene A.-M.Frischauf 847 Malignant hyperthermia hots up! K.Johnson 849 ORIGINAL ARTICLES Mutations in the RET proto-oncogene are associated H.Donis-Keller, S.Dou, D.Chi, K.M.Carlson, 851 with MEN 2A and FMTC K.Toshima, T.C.Lairmore, J.R.Howe, J.F.Moley, P.Goodfellow and S.A.Wells, Jr Exclusion of ma Iant hyperthermia susceptibility R.Sudbrak, A.Golla, K.Hogan, P.Powers, R.Gregg, 857 (MHS) from a putative MHS2 locus on chromosome I.Du Chesne, F.Lehmann-Horn and T.Deufel 17q and of the cal, (31, and y subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect Genetic mapping of the (1- and -y-subunits of the D.E.Iles, B.Segers, R.C.A.Sengers, K.Monsieurs, 863 human skeletal muscle L-type voltage-dependent calcium L.Heytens, P.J.Halsall, P.M.Hopkins, F.R.Ellis, channel on chromosome 17q and exclusion as candidate J.L.Hall-Curran, A.D.Stewart and B.Wieringa genes for malint hyperthermia susceptibility Autosomal dominant supravalvular aortic stenosis: T.M.Olson, V.V.Michels, N.M.Lindor, 869 localization to chromosome 7 G.M.Pastores, J.L.Weber, D.J.Schaid, D.J.Driscoll, R.H.Feldt and S.N.Thibodeau Exclusion of the involvement of all known Retinitis R.Kumar-Singh, G.J.Farrar, F.Mansergh, P.Kenna, 875 Pigmentosa loci in the disease present in a family of S.Bhattacharya, A.Gal and P.Humphries Irish origin provides evidence for a sixth autosomal dominant locus (RP8) Mapping the Von Hippel-Lindau disease tumour F.M.Richards, M.E.Phipps, F.Latif, M.Yao, 879 suppressor gene: identification of germline deletions by P.A.Crossey, K.Foster, W.M.Linehan, N.A.Affara, pulsed field gel electrophoresis M.I.Lerman, B.Zbar, M.A.Ferguson-Smith and E.R.Maher Mapping of the distal boundary of the X-inactivation K.A.Leppig, C.J.Brown, S.L.Bressler, K.Gustashaw, 883 center in a rearranged X chromosome from a female R.A.Pagon, H.F.Willard and C.M.Disteche expressing XIST Construction of cosmid contigs and high-resolution J.Zuo, C.Robbins, S.Baharloo, D.R.Cox 889 restriction mapping of the Huntington disease region of and R.M.Myers human chromosome 4 A transcription map of the region containing the J.M.Rommens, B.Lin, G.B.Hutchinson, S.E.Andrew, 901 Huntington disease gene Y.P.Goldberg, M.L.Glaves, R.Graham, V.Lai, J.McArthur, J.Nasir, J.Theilmann, H.McDonald, M.Kalchman, L.A.Clarke, K.Schappert and M.R.Hayden A microsatellite-based index map of human chromosome M.Litt, P.Kramer, X.Y.Hauge, J.L.Weber, Z.Wang, 909 11 P.J.Wilkie, M.S.Holt, S.Mishra, H.Donis-Keller, L.Warnich, A.E.Retief, C.Jones and J.Weissenbach PAX6 mutations in aniridia I.M.Hanson, A.Seawright, K.Hardman, S.Hodgson, 915 D.Zaletayev, G.Fekete and V.van Heyningen Cloning of the breakpoints of a submicroscopic deletion V.Greger, E.Woolf and M.Lalande 921 in an Angelnan syndrome patient Identical APC exon 15 mutations result in a variable P.Paul, T.Letteboer, L.Gelbert, J.Groden, R.White 925 phenotype in familial adenomatous polyposis and M.J.Coppes Molecular definition of the extreme size polymorphism C.Lackner, J.C.Cohen and H.H.Hobbs 933 in apolipoprotein(a) Human Molecular Genetics Contents (continued) Volume 2 number 7 July 1993

Characterization of the human fumarylacetoacetate Y.Labelle, D.Phaneuf, B.Leclerc and R.M.Tanguay 941 hydrolase gene and identification of a missense mutation abolishing enzymatic activity The genes for X-linked ocular albinism (OA1) and M.C.Wapenaar, M.T.Bassi, L.Schaefer, A.Grillo, 947 microphthaimia with linear skin defects (MLS): cloning G.B.Ferrero, A.C.Chinault, A.Ballabio and characterization of the critical regions and H.Y.Zoghbi Discordant phenotype of two overlapping deletions N.G.Pasteris, B.J.Trask, S.Sheldon and J.L.Gorski 953 involving the PAX3 gene in chromosome 2q35 Genomic organization of the sequence coding for L.Pereira, M.D'Alessio, F.Ramirez, J.R.Lynch, 961 fibriflin, the defective gene product in Marfan syndrome B.Sykes, T.Pangifinan and J.Bonadio Paired STSs amplified from radiation hybrids, and C.M.McConville, P.J.Byrd, H.J.Ambrose, 969 from associated YACs, identify highly polymorphic loci T.Stankovic, Y.Ziv, A.Bar-Shira, L.Vanagaite, flanking the ataxia telangiectasia locus on chromosome G.Rotman, Y.Shiloh, G.T.Gillett, J.H.Riley 11q22-23 and A.M.R.Taylor Identification of germiin mutations in the RB1 gene by V.Blanquet, C.Turleau, M.-S.Gross, M.Goossens 975 denaturant gradient gel electrophoresis and polymerase and C.Besmond chain reaction direct sequencing Molecular analysis of British facioscapulohumeral M.Upadhyaya, P.Jardine, J.Maynard, J.Farnham, 981 dystrophy families for 4q DNA rearrangements M.Sarfarazi, C.Wijmenga, J.E.Hewitt, R.Frants, P.S.Harper and P.W.Lunt An alternatively-spliced mRNA in the carboxy terminus D.H.Gutmann, L.B.Andersen, J.L.Cole, M.Swaroop 989 of the neurofibromatosis type 1 (NFI) gene is expressed and F.S.Collins in muscle The state of DNA methylation in the promoter and exon A.Behn-Krappa and W.Doerfler 993 1 regions of the human gene for the interieukin-2 receptor a chain (IL-2Ra) in various cell types Characterization of a human cil-antitrypsin null allele V.E.Laubach, W.J.Ryan and M.Brantly 1001 involving aberrant mRNA splicing Haplotype analysis to determine the position of a M.Ramsay, R.Williamson, X.Estivill, 1007 mutation among closely linked DNA markers B.J.Wainwright, M.-F.Ho, S.Halford, J.Kere, E.Savilahti, A.de la Chapelle, M.Schwartz, M.Schwartz, M.Super, P.Farndon, C.Harding, L.Meredith, L.Al-Jader, C.Ferec, M.Claustres, T.Casals, V.Nunes, P.Gasparini, A.Savoia, P.F.Pignatti, G.Novelli, M.Bennarelli, B.Dallapiccola, L.Kalaydjieva and P.J.Scambler Microsatellite haplotypes for cystic fibrosis: mutation N.Morral, V.Nunes, T.Casals, M.Chill6n, 1015 frameworks and evoluationary tracers J.Gimdnez, J.Bertranpetit and X.Estivill Variation of short tandem repeats within and between W.J.Wall, R.Williamson, M.Petrou, D.Papaioannou 1023 populations and B.H.Parkin Functional complementation in mouse-human radiation K.Komatsu, T.Ohta, Y.Jinno, N.Niikawa 1031 hybrids assigns the putative murine scid gene to the and Y.Okumura pericentric region of human chromosome 8 SHORT REPORTS A physical map of the C6 and C7 complement M.J.Hobart, B.A.Fernie, R.G.DiScipio 1035 component gene region on chromosome 5pl3 and P.J.Lachmann Non-conservation of a catalytic residue in a dipeptidyl N.Yokotani, K.Doi, R.J.Wenthold and K.Wada 1037 aminopeptidase IV-related protein encoded by a gene on human chromosome 7 Human Molecular Genetics Contents (continued) Volume 2 number 7 July 1993

An exonic point mutation creates a MaeII site in the J.-M.Lobaccaro, S.Lumbroso, R.Ktari, R.Dumas 1041 androgen receptor gene of a family with complete and C.Sultan androgen insensitivity syndrome MUTATION REPORTS Sequencing of exons 16 and 17 of the 3-amyloid J.Johnston, L.Lilius, K.Axelman, R.Cowburn, 1045 precursor protein gene fails to identify new mutations in K.Johansson, M.Viitanen, B.Winblad and L.Lannfelt Swedish Alzheimer's disease patients A dinucleotide deletion (-AGA115) in the tyrosinase W.S.Oetting, J.P.Fryer and R.A.King 1047 gene responsible for type I-A (tyrosinase negative) oculocutaneous albinism in a Pakistani individual A 4 basepair deletion in exon 4 of the human Y.Ma, M.-S.Liu, H.Zhang, I.J.Forsythe, 1049 lipoprotein lipase gene results in type I J.D.Brunzell and M.R.Hayden hyperlipoproteinemia Mutation analysis in patients with the typical form of J.P.Davies, B.G.Winchester and S.Malcolm 1051 Anderson- Fabry disease A missense mutation (178Cvts- Tyr) and two neutral G.Marchetti, M.Ferrati, P.Patracchini, R.Redaelli 1055 dimorphisms (1"5His and 3 3Ser) in the human and F.Bernardi coagulation factor VII gene A new disease-causing mutation in the GAP-related F.Anglani, A.Murgia, S.Bedin, E.Bresin, F.Bernardi, 1057 domain of the NF1 gene M.Clementi and R.Tenconi A novel missense mutation in the phenylalanine P.Guldberg, H.C.Lou, K.F.Henriksen, I.Mikkelsen, 1061 hydroxylase gene of a homozygous Pakistani patient B.Olsen, B.Holck and F.Guttler with non-PKU hyperphenylalaninemia An 8-bp deletion in exon B of the iduronate-2-sulphate S.Goldenfum, S.Malcolm and B.Winchester 1063 sulphatase gene in a case of Hunter disease A novel nonsense mutation, W846XI (amber J.P.Cheadle, L.N.Al-Jader and A.L.Meredith 1067 termination), in exon 14a of the cystic fibrosis transmembrane conductance regulator (CFTR) gene Human erythropoietic protoporphyria: identification of Y.Nakahashi, H.Miyazaki, Y.Kadota, Y.Naitoh, 1069 a mutation at the splice donor site of intron 7 causing K.Inoue, M.Yamamoto, N.Hayashi and S.Taketani exon 7 skipping of the ferrochelatase gene Identification of three rare frameshift mutations in exon F.Chevalier-Porst, M.Mathieu and D.Bozon 1071 13 of the cystic fibrosis gene: 1918delGC, 2118de14 and 2372del8 A new mutation causing inherited growth hormone Y.Igarashi, M.Ogawa, T.Kamijo, N.Iwatani, 1073 deficiency: a compound heterozygote of a 6.7 kb Y.Nishi, H.Kohno, T.Masumura and J.Koga deletion and a two base deletion in the third exon of the GH-1 gene A new mutation of exon 5 of the P53 gene in breast N.Carrere, R.M.Leblanc, J.Begueret, P.Blouin 1075 cancer and A.Cheyrou DNA MARKERS AND POLYMORPHISMS Dinucleotide repeat polymorphisms at the D4S126 and D.A.Tagle, K.L.Blanchard-McQuate, J.Valdes, 1077 D4S114 loci L.Castilla and F.S.Collins Dinucleotide repeat polymorphism at the DXS1146 locus H.-K.Hong, R.Giorda, M.Trucco and A.Chakravarti 1078 The detection of a VNTR at the Huntington disease L.Carlock and T.Vo 1079 genetic marker D4S10 A TaqI site identifies the *A allele at the ACP1 locus G.F.Sensabaugh and K.A.Lazaruk 1079 Human Molecular Genetics Contents (continued) Volume 2 number 7 July 1993

Tetranucleotide repeat polymorphism at D17S846 maps W.L.Flejter, J.F.Kukowska-Latallo, S.Kiousis, 1080 within 40 kb of GAS at 17ql2-q22 S.C.Chandrasekharappa, S.E.King and J.S.Chamberlain Human BgIlBclI RFLP recognized by 3' region of Y.Ding, D.R.Reed and R.A.Price 1080 human MAP 2 gene probe Dinucleotide repeat polymorphism at the human H.Dollfus, J.-M.Rozet, M.A.Musarella, J.Kaplan 1081 recoverin RCVI gene locus on chromosome 17p and A.Munnich Dinucleotide repeat polymorphism at the D11S982E H.Xiao, S.E.Ide, C.R.Merril 1081 locus and M.H.Polymeropoulos BanI and PvuU polymorphisms in intron 2 of selectin E P.K.Powers and J.E.Hixson 1082 (SELE) Dinucleotide repeat polymorphism at the locus D13S231 L.Saksova', H.-C.Hennies and A.Reis 1082 A microsatellite polymorphism at the THRB locus P.M.Brett, G.Melmer, M.M.Robertson 1083 and H.M.D.Gurling A compound nucleotide repeat in the neurofibromatosis L.B.Andersen, S.A.Tarle, D.A.Marchuk, E.Legius 1083 (NFl) gene and F.S.Collins An EcoRI polymorphism in the AMLI gene D.J.Birn, T.W.McKeithan and G.Nucifora 1084 A dintide repeat polymorphism in the human H.C.Watkins, C.A.MacRae, L.Thierfelder, 1084 LAMB2 gene on chromosome lq W.J.McKenna, C.E.Seidman and J.G.Seidman Dinucleotide repeat polymorphism at the D6S348 locus M.S.Kansara and R.S.Athwal 1085 Two consecutive dinucleotide repeats constitute an B.C.Byth and D.W.Cox 1085 informative marker at the c-antichymotysin (AACT) locus A PstI polymorphism in the 3' end of the human type M.L.Delbridge and J.A.Savige 1086 IV coilagen alpha 3 chain (COL4A3) gene A CA dinucleotide polymorphism at D17S107 D.F.Barker, K.Nguyen and P.R.Fain 1086 (17ql2-q24) Tetranudeotide repeat polymorphism at the D8S344 K.Ward, R.Riley, J.Lu, M.Robertson and L.Nelson 1087 locus Length polymorphsim within a complex dinucleotide M.D.Briggs and D.H.Cohn 1087 repeat in the human decorin (DCN) gene NEW HUMAN DNA POLYMORPHISMS New human DNA polymorphisms submitted to the 1089 genome data base Author index 1095