Anti-P2RY6 Antibody (ARG65793)

Product datasheet [email protected]

ARG65793 Package: 100 μl anti-P2RY6 antibody Store at: -20°C

Summary

Product Description Rabbit Polyclonal antibody recognizes P2RY6

Tested Reactivity Hu

Predict Reactivity Ms, Rat

Tested Application IHC-P, WB

Host Rabbit

Clonality Polyclonal

Isotype IgG

Target Name P2RY6

Antigen Species Human

Immunogen Synthetic peptide of Human P2RY6.

Conjugation Un-conjugated

Alternate Names P2Y purinoceptor 6; P2Y6

Application Instructions

Application table Application Dilution

IHC-P 1:50 - 1:200

WB 1:500 - 1:2000

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Positive Control WB: Human brain malignant glioma tissue; IHC-P: Human ovarian cancer and Human lung cancer.

Calculated Mw 36 kDa

Properties

Form Liquid

Purification Affinity purification with immunogen.

Buffer PBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol.

Preservative 0.05% Sodium azide

Stabilizer 40% Glycerol

Concentration 1.1 mg/ml

Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. www.arigobio.com 1/3 Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links GeneID: 5031 Human

Swiss-port # Q15077 Human

Gene Symbol P2RY6

Gene Full Name pyrimidinergic receptor P2Y, G-protein coupled, 6

Background The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

Function Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. [UniProt]

Images

ARG65793 anti-P2RY6 antibody IHC-P image

Immunohistochemistry: Paraffin-embedded Human ovarian cancer tissue stained with ARG65793 anti-P2RY6 antibody (left) at 1:40 dilution, or the same antibody pre-incubated with antigen (right). (Original magnification: X200) .

ARG65793 anti-P2RY6 antibody WB image

Western blot: 40 µg of Human brain malignant glioma tissue lysate stained with ARG65793 anti-P2RY6 antibody at 1:550 dilution.

www.arigobio.com 2/3 ARG65793 anti-P2RY6 antibody IHC-P image

Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG65793 anti-P2RY6 antibody (left) at 1:40 dilution, or the same antibody pre-incubated with antigen (right). (Original magnification: X200) .