27 8 Endocrine-Related P L M Dahia et al. Metastatic pheochromocytomas/ 27:8 T41–T52 Cancer paragangliomas THEMATIC REVIEW HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES Metastatic pheochromocytomas and paragangliomas: proceedings of the MEN2019 workshop Patricia L M Dahia1, Roderick Clifton-Bligh2, Anne-Paule Gimenez-Roqueplo3,4, Mercedes Robledo5,6 and Camilo Jimenez7 1Division of Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA 2Department of Endocrinology, Royal North Shore Hospital, Northern Clinical School, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia 3Université de Paris, INSERM, PARCC, Paris, France 4AP-HP, Hôpital Européen Georges Pompidou, Genetics Department, Paris, France 5Human Cancer Genetics Program, Spanish National Cancer Research Center, Madrid, Spain 6Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain 7Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Correspondence should be addressed to P L M Dahia:
[email protected] This paper is part of a thematic section on current knowledge and future research opportunities in hereditary endocrine tumours, as discussed at MEN2019: 16th International Workshop on Multiple Endocrine Neoplasia, 27–29 March 2019, Houston, TX, USA. This meeting was sponsored by Endocrine-Related Cancer Abstract Key Words Pheochromocytomas and paragangliomas (PPGLs) are adrenal or extra-adrenal f pheochromocytomas autonomous nervous system-derived tumors. Most PPGLs are benign, but approximately f paragangliomas 15% progress with metastases (mPPGLs). mPPGLs are more likely to occur in patients f metastatic with large pheochromocytomas, sympathetic paragangliomas, and norepinephrine- f mutation secreting tumors.