andtheirReceptors Discover more Text Colour Key toConjugations: ......

Conjugation Phycoerythrin FITC at abcam.com/chemokines Text Colour ...... Conjugation Unconjugated Bioti

Chemokines Alpha Chemokines(CXC) calcium concentrationandenzymereleaseinmonocytes. cysteines (C-C).Thisfamilyofchemokinesinducechangesinintracellular by twoadjacent Beta chemokinesaresecretedproteinscharacterized Beta Chemokines(CC) and otherenzymes. ofmyloperoxidase the release with degradation, chemoattractants andactivators,including amino acid(C-X-C). act Alpha chemokines primarilyonneutrophilsas by one the firsttwocysteineresiduesinaminoacidsequence familyischaracterizedbytheseparationof The alpha Alpha Chemokines (CXC) foundonthesurfacesoftheirtargetcells. that areselectively receptors, chemokine receptors called transmembrane with Gprotein-linked effects byinteracting invertebrates. Theseproteinsexerttheirbiological for other described been have but none bacteria, some and viruses vertebrates, some all in found are Chemokines or development. maintenance normal processesoftissue of cellsduring the migration in controlling homeostatic andareinvolved others areconsidered site ofinfection,while to promotecellsoftheimmunesystema an immuneresponse during and canbeinduced pro-inflammatory Some chemokinesareconsidered cells; theyarechemoattractantcytokines. shape. Thenameisderivedfromtheirabilitytoinducedirectedchemotaxisinnearbyresponsive that arekeytoformingtheir3-dimensional locations in conserved of fourcysteineresidues 8-10 kDainsize),andthepresence approximately are a family of Chemokines small .Theyareclassifiedaccordingto shared structuralcharacteristicssuchassmallsize(theyareall CXCL1 Chemokine CXCL16 CXCL15 CXCL14 CXCL13 CXCL12 CXCL11 CXCL10 CXCL9 CXCL8 CXCL7 CXCL6 CXCL5 CXCL4 CXCL3 CXCL2 B6 Small inducible Lungkine Bolekine chemokine) / kidney-expressed BRAK (breastand BCA-1 SDF-1 I-TAC IP-10 MIG IL8 NAP-2 GCP-2 ENA-78 PF-4 (MIP2 GRO- (MIP2 GRO- (MIP2 GRO- Alternative name g b a a g b a /MGSA /KC) /MGSA /KC) /MGSA /KC) / b g b a

. mammary epithelialcells,endothelialactivatedmonocytes,macrophagesand Inducible neutrophilchemoattractantfactor.Detectedinmammaryfibroblasts, Role /expression cells andnaturalkillerTcell bound moleculeorasolublechemokine.Chemoattractantforseveralsubsetsof T inflammatory cytokinesIFNgammaandTNFalpha.Expressedasacellsurface lymphoid organsandbycellsfoundintheredpulpofspleen,responseto the such asatherogenesis.ProducedbydendriticcellsfoundintheTcellzonesof low densitylipoprotein,suggestingthatitmaybeinvolvedinpathophysiologies Acts asascavengerreceptoronmacrophages,whichspecificallybindstooxidized a specificcellsurfacereceptorhasnotyetbeenfound. a lesserextentincertainfetaltissues.Nohumanhomologhasbeenidentifiedand murine ,andcanalsobefoundinothermucosalendocrineorgans to Recruits neutrophilsduringlunginflammation.Itisabundantinepithelialcellsof the , possiblyasaresultofitsabilitytoblockendothelialcellchemotaxis. of thesecellsandcanstimulatethemigrationactivatedNKcells.Alsoinhibits implicated inhoming prostaglandin-E2. Alsoapotentchemoattractantandactivatorofdendriticcells.Itis and canactivatethesecellsinthepresenceofaninflammatorymediator from manyestablishedtumorcelllines/cancers.Achemoattractantformonocytes Constitutively expressedatthemRNAlevelincertainnormaltissuesbutabsent the homingofBlymphocytestofollicles. cells expressingBurkitt’slymphomareceptor1(BLR1).Itmaythereforefunctionin ), apparentlybystimulatingcalciuminfluxinto,andchemotaxisof, Preferentially promotesthemigrationofBlymphocytes(comparedtoTcellsand Strongly expressedinthefolliclesofspleen,lymphnodes,andPeyer’spatches. progression. very importantfactorincarcinogenesisandtheneovascularisationlinkedtotumor plays animportantroleinangiogenesisbyrecruitingendothelialprogenitorcells.A fetal livertobonemarrowandtheformationoflargebloodvessels.Inadulthoodit entry. Duringembryogenesis,CXCL12directsmigrationofhematopoieticcellsfrom A strongchemoattractantforlymphocytes.BindingtoitsreceptorinhibitsHIV1 Induced byIFNgammaandbeta. pancreas andliverastrocytesatmoderatelevelsinthymus,spleenlung. skin immuneresponses.Expressedathighlevelsinperipheralbloodleukocytes, play animportantroleinCNSdiseaseswhichinvolveTcellrecruitmentand neutrophils ormonocytes.InducescalciumreleaseinactivatedTcells.Itmay Chemoattractant forinterleukin-activatedTcellsbutnotunstimulatedcells, regulation ofangiogenicactivityincancer. cutaneous Tcelllymphomaandchronichepatitis.Stronglysuggestedinthe Involved inavarietyofinflammatorypathologiessuchasHIVencephalitis, ranging fromneutrophilstohepatocytes,endothelialcellsandkeratinocytes. hematopoietic progenitorproliferation.Producedbyawidevarietyofcelltypes Chemoattractant forCD4 murine cells. of colonyformationhematopoieticprogenitors.HumanCXCL9isactiveon of tumorgrowth,angiogenesisandinhibition chemoattracts Th1lymphocytesandalsoexertsotheractivitiesincludinginhibition Produced bystimulatedmonocytes,macrophagesandendothelialcells.Selectively in cancerandidiopathicpulmonaryfibrosis. suggested roleintheregulationofangiogenicactivity factor. Attractsneutrophils,,andT-cells(butnotmonocytes).Strongly response to inflammatory stimulus. A chemoattractant and also a potent angiogenic Major mediatorofinflammatoryresponse,secretedbyseveralcelltypesin plasminogen activatorbysynovialcells. and sulfatedglycosaminoglycan.Alsostimulatesformationsecretionof accumulation, prostaglandinE2secretionandsynthesisofhyaluronicacid processes includingDNAsynthesis,mitosis,glycolysis,intracellularcAMP Potent chemoattractantandactivatorofneutrophils.Stimulatesvariouscellular Neutrophil recruitmenttoinflammatorysites. concomitantly withCXCL8inresponsetostimulationIL1orTNFalpha. Chemoattractant forneutrophilsandinvolvedintheiractivation.Produced Expressed byfibroblasts.Inducedbacteriallipopolysaccharides. and woundrepair. chemoattractant forneutrophilsandfibroblasts.Probablyhasaroleininflammation inhibiting localantithrombinIIIactivityandpromotingcoagulation.Strong heparin likemoleculesontheendothelialsurfaceofbloodvessels,thereby Released fromalphagranulesofactivatedplatelets,bindstoheparin.Neutralizes affects endothelialcellsinanautocrinefashion. Induces chemotacticactivityinneutrophils.Mayplayaroleinflammationand Promotes neutrophilandbasophilchemotaxisdegranulation. + T cells and inhibits early normal and leukemic Tcellsandinhibitsearlynormalleukemic between theconservedcysteineresidues)nearN-terminal. CX3C cysteinemotif(3aminoacids Delta chemokinescontainaunique Delta Chemokines(CX3C) extended C-terminus. and havean found intheCCandCXCchemokines normally residues (Csubfamily)lacktwoofthefourinvariantcysteine Gamma chemokines Gamma Chemokines(C) ab9905, Abcam antibodies (CXCL15 ) (CXCL15 protein) ab49907 ab46010, ab33178, ab9975 ab9797, ab18919 ab9955, ab26946 ab9938, ab9720, ab10769, ab9554, ab9923 ab9802, ab9561, ab9843 ab9950, ab56320

ab25903 ab8099 ab17703 ab17520 ab17694 ab49735 ab17678 , ab46008 ab27369 ab14040

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unknown Unknown CXCR5 CXCR4 (CD183b) CXCR3 betaisoform (CD183b) CXCR3 betaisoform (CD183b) CXCR3 betaisoform (IL8RB), DARC CXCR1 (IL8RA),CXCR2 CXCR2 (IL8RB) CXCR2 (IL8RB) CXCR1 (IL8RA), CXCR2 (IL8RB) (CD183b) CXCR3 betaisoform CXCR2 (IL8RB) CXCR2 (IL8RB) CXCR2 (IL8RB) Main receptors CX3CL1 Chemokine Delta Chemokines(CX3C) Beta Chemokines(CC) CCL28 CCL27 CCL26 CCL25 CCL24 CCL23 CCL22 CCL21 CCL20 CCL19 CCL18 CCL17 CCL16 CCL15 CCL14 CCL13 CCL12 CCL11 CCL9/10 CCL8 CCL7 CCL6 CCL5 CCL4 CCL3L1 CCL3 CCL2 XCR1.XCR1 receptor chemokine CCL1 Chemokine e MEC CTAK /ILC(ESkine) Eotaxin-3 TECK MPIF-2 /Eotaxin-2 CK MPIF-1 /MIP-3 ABCD-1 MDC /STCP-1 / Exodus 2 6Ckine /SLC Exodus 1 MIP-3 Exodus 3 MIP-3 PARC /AMAC-1 MIP-4 /DC-CK1 TARC /ABCD-2 HCC-4 /LEC MIP-1 HCC-2 /LKN-1 HCC-1 MCP-4 MCP-5 Eotaxin MIP-1 MCP-2 MCP-3 C-10 /MRP-2 RANTES duplication, MIP-1 LAG-1 duplication LD78 MIP-1 MCP-1 /MCAF(JE) Scya1 1-309 (TCA-3), Alternative name Neurotactine Fractalkine / Alternative name b -8 b a b d g a gene gene MRP-2 /MIP-5 / ELC / /ELC / LARC/ /LARC/ /LD78 a b extracutaneous epithelialtissues,includingdiversemucosalorgans. mobilization inadose-dependentmannerandmayplayrolethephysiologyof Chemoattractant forrestingCD4orCD8Tcellsandeosinophils.Itinducescalcium homing oflymphocytestocutaneoussites. Attracts skin-associatedmemoryTlymphocytes.CCL27mayplayaroleinmediating basophils. that havebeenstimulatedwiththecytokineIL4.Chemoattractantforeosinophilsand Expressed byseveraltissuesincludingheart,lungandovaryin endothelial cells inactive onperipheralbloodlymphocytesandneutrophils. Chemoattractant fordendriticcells,thymocytesandactivatedmacrophages,butis formation inmyleloidprogenitorcells. weakly expressedinactivatedmonocytesandTlymphocytes.Inhibitscolony Like CCL11,activatesandattractseosinophilsbasophils.CCL24mRNAis adult bonemarrowandplacenta. skeletal muscleandpancreas.TherearemoderatelevelsofCCL23infetalliver, proliferation ofmyeloidprogenitorcellsandishighlyexpressedinadultlung,liver, Chemoattractant formonocytes,restingTlymphocytesandneutrophils.Inhibits inflammatory sitesandotheraspectsoftheirphysiology. resting Tlymphocytes.Mayplayaroleinthetrafficking of activatedTlymphocytesto and dendriticcells.Ithasnochemoattractantactivityfor , neutrophilsor Chemoattractant fornaturalkillercells,chronicallyactivatedTlymphocytes, the cytokinefamily). cells. CCL21isaknownreceptorforsmallinduciblecytokineA19(anothermemberof chemokine (ELC)receptor,CCR7.ChemoattractantforthymocytesandactivatedT organs, integrin-mediatedlymphocyteadhesion,andmayactviatheEBI1ligand Research indicatesthatCCL21influenceslymphocytehomingtosecondarylymphoid anddendriticcellstowardsepithelialcells. be involvedinformationandfunctionofthemucosallymphoidtissuesbyattracting CCL20 inhibitsproliferationofmyeloidprogenitorsincolonyformationassays.Itmay Chemoattractant that attracts lymphocytesandneutrophils,butnotmonocytes. human Tandhematopoieticprogenitorcells. anti-inflammatory cytokineIL10.Attractsculturedhumanlymphcytes,dendriticcells, can bestronglyup-regulatedbyinflammatorysignalsordown-regulatedthe Constitutively expressedinvariouslymphoidtissues.Thelevelofexpression lymph nodes,placenta,andbonemarrow. be involvedinBcellmigrationintolymphnodes.Expressedathighlevelslung, humoral andcell-mediatedimmunity.SomeevidencesuggeststhatCCL18mayalso attracts naiveTcells,CD4 A chemoattractantforlymphocytesbutnotmonocytesorgranulocytes.Specifically,it cell developmentinthethymusaswelltraffickingandactivationofmatureTcells. to chemokinereceptorsCCR4andCCR8.ThisplaysimportantrolesinT Chemoattractant forTlymphocytesbutnotmonocytesorgranulocytes.CCL17binds of myeloidprogenitorcells.ItsexpressionisupregulatedbyIL10. shows apotentmyelosuppressiveactivityandsuppressesproliferation Chemoattractant forlymphocytesandmonocytesbutnotneutrophils.Italso is thoughttoactthroughtheCCR1receptorbutalsobindsCCR3. Induces changesinintracellularcalciumconcentrationmonocytes.CCL15 in varioustissuesincludingspleen,bonemarrow,liver,muscleandgut. exhibiting 46%aminoacidhomologytoCCL3andCCL4.Expressed Produced asaprecursorwhichisprocessedtogeneratematureactiveprotein monocytes andTlymphocytes. Similar toCCL7.Powerfuleosinophilchemoattractant.Induceschemotaxisof not activeonmouseneutrophils. Exhibits onlyaweakresponseonmouseeosinophilsathighconcentrationsandis A strongchemoattractantforhumanmonocytesandmurineperitonealmacrophages. eosinophils. Mayplayafundamentalroleinthedevelopmentofallergicresponses. Regulates therecruitmentandactivationofinflammatoryleukocytes,particularly cause ofDubin-Johnsonsyndrome. been observedinasubsetofcisplatinresistantcelllines.DefectsCCL9/10arethe the MRPfamilyofmultidrugresistancerelatedproteins,anditsoverexpressionhas cellular cisplatintransporter,withhighestexpressioninliver.CCL9/10isamemberof Mediates hepatobiliaryexcretionofnumerousorganicanionsandmayfunctionasa intestine andperipheralbloodcells. to inflammatoryhostresponsesandisfoundinthehighestconcentrationsmall Chemoattractant formonocytes,lymphocytes,basophilsandeosinophils.Important degrades componentsoftheextracellularmatrix. The proteinisan Secreted chemokinewhichattractsmacrophagesduringinflammationandmetastasis. activated Tcelllines,expressionofCCL6isgreatlyreduced. stimulated withthecytokineGM-CSFandcanbeinducedinmouselungbyIL13.In differentiation. CCL6ishighlyexpressedinbonemarrowculturesthathavebeen and macrophagelineages,canbeinducedunderconditionssuitableformyeloidcell Chemoattractant onlyexpressedinrodents.Inmice,cellsfromneutrophil suppressive factorsproducedbyCD8 release ofhistaminefrombasophilsandactivateseosinophils.OnethemajorHIV Chemoattractant formonocytes,memoryThelpercellsandeosinophils.Itcausesthe T cells. Chemoattractant andadhesi mediates bothleukocytemigrationandadhesion. by inflammatorysignals.Itsreceptor,CX3CR1,aspecificreceptorforCX3CL1, kidney, skeletalmuscleandtestis.Up-regulatedinendothelialcellsmicroglia Leukocyte chemoattractantexpressedinvarioustissuesincludingbrain,heart,lung, Role / expression in vivo substrate of matrix metalloproteinase 2, an enzyme which substrateofmatrixmetalloproteinase2,anenzymewhich + andCD8 + + T cells and thus may play a role in both Tcellsandthusmayplayaroleinboth T cells. Tcells.

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ab25088, Abcam antibodies ab36692, ab37326 ab36771 ab2164, ab2164 ab10370, ab62306 ab9929, ab62138 ab53002, ab10379 ab10364, ab10350 ab9349, ab9829 ab9351, ab9831 ab9849, ab9816, ab30975 ab626, ab14531, ab14528, ab55752 ab9558, ab18938, ab9737 ab8018, ab3373 ab10392, ab9681, ab10351, ab33835 ab9679, ab9675, ab10384 ab36129 ab9673, ab62137 ab21554 ab7202, Abcam antibodies ab17439

ab17514 ab12749 ab17551 ab25904 ab12732 ab11455 ab17424

ab17707 ab39627

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CX3R1 Main receptors CCR10, CCR3 CCR3,CCR2,CCR10 CCR3 CCR9 CCR3 CCR1 CCR4 CCR7 CCR6 CCR7 unknown CCR4, DARC CCR1 CCR1, CCR3 CCR1 CCR11 CCR1, CCR2,CCR3, CCR2 CCR3 CCR1 CCR11 CCR1, CCR2,CCR5, CCR1, CCR2,CCR3 CCR1, CCR2,CCR3 CCR5, DARC CCR1, CCR3,CCR4, CCR1, CCR5 binding protein2 CCR5, Chemokine CCR1, CCR5 CCR2 CCR8, CCR11,DARC Main receptors CX3CR1 Chemokine CCR11 CCR10 CCR9 CCR8 CCR7 CCR6 CCR5 CCR4 CCR3 CCR2 CCR1 Chemokine CXCR5 CXCR4 beta isoform CXCR3 CXCR2 CXCR1 Chemokine Other Chemokinereceptors Delta Chemokinereceptors Beta Chemokinereceptors Alpha Chemokinereceptors Gamma Chemokines(C) XCL2 XCL1 Chemokine DARC Chemokine

SCM-1b Lymphotactin Alternative name Alternative name CD192 CD191 Alternative name CD183b IL8RB IL8RA Alternative name Alternative name cells. Induceschemotaxisofcellsexpressingth Predominantly expressedinactivatedTcells.Alsofoundatlowlevelsunstimulated regulator oflymphocytemotilityandadhesionduringacuteallograftrejection. is exertedonmonocytesorneutrophils.IthasrecentlybeenshownthatXCL1akey and NKcells,indicatingapossiblemessengerroleinTcellchemoattraction.Noactivity cells (absentinCD4 Expression isrestrictedtoactivatedCD8 Role / expression can be inhibited by binding of CX3CL1. Also implicated in tumor . can beinhibitedbybindingofCX3CL1.Alsoimplicatedintumormetastasis. and isaco-receptorforHIV12envelopefusionvirusinfection,which migration andadhesion.ReceptorforthenoveltransmembranemoleculeCX3CL1 Expressed inavarietyofhumantissuesandcelllineswhereitmediatesleukocyte Role / expression including CCL13,CCL8,andCCL2.AlsobindsCCL11. Specifically bindsthemonocytechemoattractantproteinfamilyofchemokines, monocytes atthenucleotidelevel. in humans.Someexpressioncanbefoundthebrain,,lymphnodeand CCL28. AssociatedwithTh2lymphocytes,foundpredominantlyinthethymus, Receptor fortheskin-associatedchemokineCCL27aswellnovel different segmentsofthegastrointestinaltract. colon suggestsaroleinthefunctionalspecializationofimmuneresponses The differentialexpressionofCCR9byTlymphocytesthesmallintestineand majority ofbeta-chemokinefamilymembersbutspecificfunctionremainsunknown. the developmentandgrowthof vascular tumors.Thisreceptorappearstobindthe chemokine-driven recirculationofleukocytesandpossiblechemokineeffectson Expressed inarangeoftissuesandhematopoieticcells.Functions and Tcells, and atlowerlevelsinperipheralbloodleukocytes. expression hasbeenreportedinspleenandthymus,naturalkillercells,monocytes the antigenicchallengesitesandspecializedareasoflymphoidtissues.CCR8 apoptosis. CCR8maycontributetotheproperpositioning of activatedTcells within its ligandssuggestaroleintheregulationofmonocytechemotaxisandthymiccell This receptorispreferentiallyexpressedinthethymus.Studiesofthisand this receptor. lymphocytes. ThechemokineCCL19hasbeenreportedtobeaspecificligandof dendritic cellmaturationandisthoughttobeamediatorofEBVeffectsonB shown tocontrolthemigrationofmemoryTcellsinflamedtissues,stimulate Expressed inlymphoidtissuesandactivatedBTlymphocytes,hasbeen antigen drivenBcelldifferentiation. inflammatory andimmunologicalresponses.ImportantforBlineagematuration it mayregulatethemigrationandrecruitmentofdendriticTcellsduring Preferentially expressedbyimmaturedendriticcellsandmemoryTwhere disease. lymphocytes. Majorco-receptorimplicatedinsusceptibilitytoHIV1infectionand cells, CD34 Expressed onseveralcelltypesincludingperipheralblood-deriveddendritic functional responsivenesstothymus-andactivation-regulated chemokine. TCR andCD28engagement.ActivatedTh1cellsup-regulateCCR4expression receptors, theexpressionofCCR4andCCR8istransientlyincreasedfollowing CCR4 ispreferentiallyexpressedonTh2-typecells.Incontrasttootherchemokine key roleinallergicdiseasesandisaco-receptorforHIV12. by competingforthebindingofCCL11/CCL24toCCR3.CCR3isthoughtplaya The agonistsforCXCR3(CXCL9,CXCL10,CXCL11)actasantagonistsCCR3 basophils, Th2cells,CD34 these tissues,CCR3isexpressedinspecificcell types, includingeosinophils, kidney, liver,lymphnode,placenta,skin,spleen,thymus,thyroid and uterus.Within Receptor forCCL11andCCL24.Expressedinblood,brain,lung,bonemarrow, mediate monocytechemotaxis. several monocytechemoattractantproteins(CCL2,CCL7,CCL13)whichspecifically basophils inhumans,andalsoperitonealmacrophagesmice.Itisareceptorfor Expressed onthesurfaceofmonocytes,activatedmemoryTcells,Bcellsand T cellswithinthelymphocytepool. suggestion thatthischemokinereceptorisrestrictedtomemory Expressed onperipheralbloodlymphocytesandmonocytes.There is some Role / expression in lymphnodesaswellspleen. Specifically expressedinBurkitt’slymphomaandlymphatictissues,suchasfollicles umbilical cordendothelialcells. Highly expressedinbrain,heart,whitebloodcells,vascularendothelialcellsand B cellsandNKcells). Predominantly expressedonTlymphocytes,andalsootherlymphocytes(some Expressed onneutrophils. Expressed onneutrophils. Role / expression vivax and CCL17.Itisalsothereceptorforhumanmalariaparasites A non-specificreceptorformanychemokinessuchasCXCL8,CXCL1,CCL5,CCL2 Role / expression and Plasmodium knowlesi + hematopoietic progenitor cells and certain activated / memory Th1 hematopoieticprogenitorcellsandcertainactivated/memoryTh1 + T cells). Produced by lymphocytes and acts on both lymphocytes Tcells).Producedbylymphocytes and actsonbothlymphocytes + hematopoetic progenitors, keratinocytes and mast cells. hematopoeticprogenitors,keratinocytesandmastcells. . It is also responsible for the Duffy blood group . ItisalsoresponsiblefortheDuffyblood group + T cells and other class I MHC restricted T TcellsandotherclassIMHCrestricted Plasmodium Plasmodium ab8021, ab7200 Abcam antibodies ab1660, ab32564 ab3904, ab30718 ab1662, ab38567 ab1663, ab32399 ab1657, ab1659, ab13168 ab1673, ab32048 ab1669, ab59550 ab1667, ab32512 ab32144, ab1668 ab13240 ab1681, Abcam antibodies ab12965, ab19017 ab2074, ab1671 ab10402 ab14935, ab13018, Abcam antibodies ab40821, ab58965 Abcam antibodies ab51795, ab9955 Abcam antibodies ab25790 ab38998 ab38989

, ,

Main receptors Main receptors ab39007 ab38991 Main receptors Main receptors XCR1 Main receptors , ab8042 , ab8042

000_13_ABC