1st International Meeting on Respiratory Pathogens (IMRP) 2015 ƒ "Epidemiological Evaluation of Infants and Young ƒ "Multi-strain Antibody Response following Acute Children with Laboratory-Confirmed Respiratory Influenza A: Implications for Seroepidemiology" Furama RiverFront, Singapore Syncytial Virus Infection in England, 2010-2014" [ASN105] [ASN045] Stacy Todd (Liverpool School of Tropical Medicine) (UK) Organised by International Society for Influenza and other Respiratory Virus Diseases (ISIRV) Rachel Reeves (Farr Institute of Health Informatics Research) (UK) ƒ "Mycobacterium tuberculosis Acetyltransferase Day 1 (Wednesday, 2 September 15) reduces the oxidative stress response through 08:00 AM Registration (Foyer) & Poster Setup (Jupiter Room) expression of peroxisomal membrane transporter 09:00 AM Venus protein" [ASN012] Welcome Address by IMRP Chairperson Geetanjali Ganguli (KIIT University) (India) A/Prof Vernon Lee 3:45 PM Teabreak Opening Remarks by ISIRV Chairperson 4:00 PM Venus I/II Venus III A/Prof Lance Jennings Parallel Session 4 Parallel Session 3 Opening Remarks by Guest-of-Honour “Evolution and Molecular Epidemiology of “Advances in Respiratory Pathogen Vaccines” A/Prof Benjamin Ong Respiratory Infections” Director of Medical Services, Ministry Of Health, Singapore Chairperson: Dr Jean-Michel Heraud Chairperson: A/Prof Gavin Smith 09:30 AM Keynote Address (Institut Pasteur) (Madagascar) (Duke-NUS Medical School) (Singapore) “Global Health Responses to Emerging Threats and the BRAVE Initiative” ƒ “Clinical Assessment of Simian Adenovirus ƒ “Bioinformatics of respiratory pathogens: From Dr Sylvie Briand (World Health Organization) ChAdOx1 Expressing Conserved Influenza A sequence to structure to molecular mechanisms” 10:15 AM Teabreak Antigens in a Prime:Boost Regimen with MVA” [Invited Speaker] 10:45 AM Plenary I [ASN010] Dr Sebastian Maurer-Stroh (A*STAR Bioinformatics “Emerging Respiratory Viruses of Concern” Lynda Coughlan (University of Oxford) (UK) Institute) (Singapore) Prof Malik Peiris (University of Hong Kong) (Hong Kong) ƒ “Cellular immune responses after live attenuated ƒ “Selective Bottlenecks Shape Evolutionary Pathways 11:15 AM Plenary II influenza vaccination in children, a clinical trial” Taken During Mammalian Adaptation Of A 1918- “Emerging Issues among Respiratory Bacteria” [ASN189] Like Avian Influenza Virus” [ASN037] Prof David Murdoch (University of Otago) (New Zealand) Kristin Greve-Isdahl Mohn (University of Bergen) Louise Moncla (University of Wisconsin-Madison) (US) 11:45 AM Mercury Room (Norway) Lunch Session on Ebola ƒ “Development of a Universal Live-Attenuated ƒ "Predicting The Antigenic Evolution Of Pandemic Chairperson: A/Prof Teo Yik Ying (CIDER) (Singapore) Influenza H1N1 Vaccine Strain” [ASN011] H1N1 Influenza Virus In Humans Using ƒ “Advances in Ebola Virus Vaccines” Ke Xu (Institut Pasteur of Shanghai) (China) Diversifying Selection Analysis" [ASN087] Prof Frederick Hayden (University of Virginia) (US) Alexandra Lee (J. Craig Venter Institute) (US) ƒ “Host jump of emerging viruses: Flu, MERS-CoV and Ebola” ƒ "Quantifying Protection Against Influenza Virus ƒ "Genetic Drift of Hemagglutinin (HA) of Influenza A/Prof Yi Shi (Chinese Academy of Sciences) (China) Infection Measured By Hemagglutination-inhibition A(H3N2) Viruses Circulating in Cameroon Between ƒ “Clinical care of patients with Ebola Virus Disease” Assays In Vaccine Trials" [ASN098] 2010 and 2013" [ASN086] A/Prof Robert Fowler (University of Toronto) (Canada) Xiahong Zhao (Saw Swee Hock School of Public Health) Richard Njouom (Centre Pasteur of Cameroon) ƒ “Clinical Management of Ebola Virus Disease Patients in the U.S. and Europe” (Singapore) (Cameroon) A/Prof Timothy Uyeki (US Centers for Disease Control and Prevention) (US) ƒ “Molecular Epidemiology and Clinical ƒ “First description of arenaviruses endemic to ƒ “Ebola: Lessons for S.E. Asia” Characterization of Influenza B among Pediatric Southeast Asia with evidence of human respiratory Prof Richard Coker (London School of Hygiene and Tropical Medicine & National University of Singapore) (Singapore) Acute Respiratory Infection in Central Vietnam disease” [ASN073] 1:30 PM Venus I/II Venus III during 2007-2013 seasons” [ASN199] Philippe Buchy (GlaxoSmithKline Vaccines Asia Pacific) Parallel Session 1 Parallel Session 2 Keisuke Yoshihara (Nagasaki University) (Japan) (Singapore) “Burden and Epidemiology of Acute Respiratory “Immunology of Respiratory Pathogens (including 6:00 PM Jupiter Room Venus III Infections” Disease Pathogenesis and Host Dynamics)” Expert Dialogue on Infection Control Chairperson: Dr Nikki Shindo Chairperson: Prof Menno de Jong “Evidence-based Measures for Personal Protective (World Health Organization) (Switzerland) (University of Amsterdam) (Netherlands) Equipment and Hygiene for Healthcare Workers and ƒ “Epidemiology of Influenza in a household cohort ƒ “Protective immunity in the human airway against the Public against Respiratory Infections” study” [Invited Speaker] respiratory viral infections” [Invited Speaker] (Limited Slots Available) Prof Ben Cowling (University of Hong Kong) (Hong Dr Chris Chiu (Imperial College London) (UK) Chairperson: Dr Hsu Li Yang (Mount Elizabeth Novena Poster Session I with Authors Kong) Hospital) (Singapore) (Networking Drinks) ƒ “Community-Acquired Pneumonia and Etiologies in ƒ “Immunology of influenza and pneumococcal ƒ Dr Nikki Shindo (World Health Organization) the Hospitalized Setting” [Invited Speaker] disease” [Invited Speaker] (Switzerland) Dr Seema Jain (US Centers for Disease Control and Prof Lau Yu Lung (University of Hong Kong) (Hong ƒ A/Prof Timothy Uyeki (US Centers for Disease Control Prevention) (US) Kong) and Prevention) (US) ƒ "Clinical Presentations and Risk Factors for Mortality ƒ "Influenza Virus and Respiratory Syncytial Virus ƒ A/Prof Brenda Ang (Tan Tock Seng Hospital) of Severe Influenza Infections in a Tertiary Care Infections in Immunocompetent and (Singapore) Hospital, Singapore, 2011–2014" [ASN024] Immunocompromised Patients and Ferrets" 7:30 PM Appreciation Dinner (Invited Speakers Only) Hanley Ho (Tan Tock Seng Hospital) (Singapore) [ASN178] 9:00 PM End of Day 1 Koert Stittelaar (Viroclinics Biosciences) (Netherlands) ƒ "Clusters of human infections with avian influenza ƒ "Cell Cycle Independent Role of Cyclin D3 in Host A(H7N9) in China, March 2013 – November 2014" Restriction of Influenza Virus Infection" [ASN068] [ASN121] Ying Fan (University of Hong Kong Pasteur Research Pole) Bo Liu (Chinese Center for Disease Prevention and Control) (Hong Kong) (China) Day 2 (Thursday, 3 September 15) 08:00 AM Registration (Foyer) & Poster Setup (Jupiter Room) 1:45 PM Venus I/II Venus III 08:30 AM Venus Parallel Session 7 Parallel Session 8 “Surveillance Systems and Public Health Prevention “AVG Session – Clinical Management of SARI / Plenary III Strategies” ALRIs including Critical Care” “A Vaccine Surrogate for the Prevention of RSV Disease” Dr JoAnn A. Suzich (MedImmune) (US) Chairperson: Dr Daniel Jernigan (US Centers for Disease Chairperson: Prof Lau Yu Lung Control and Prevention) (US) (University of Hong Kong) (Hong Kong) 09:00 AM Plenary IV ƒ ƒ “New Anti-viral Therapies for RVIs” “Surveillance and Vaccination Strategies of “Clinical Management of SARI Immuno-modulatory Prof Frederick Hayden (University of Virginia) (US) Respiratory Infectious Diseases in China: Success and Therapies” [Invited Speaker] 09:30 AM Teabreak Challenges” [Invited Speaker] Prof David Hui (Chinese University of Hong Kong) (Hong Dr Luzhao Feng (Chinese Center for Disease Control and Kong) 09:45 AM Venus I/II Venus III Prevention) (China) Parallel Session 5 Parallel Session 6 ƒ "Human, Environmental and Animal Surveillance of ƒ “Advances in Critical Care in Severe Acute “AVG Session – Treatment Options for Respiratory “New Advances in Diagnostics” Influenza A(H5N1) Virus in Cambodian Live Poultry Respiratory Infections” [Invited Speaker] Infections” Markets" [ASN138] A/Prof William A. Fischer (University of North Chairperson: A/Prof Lance Jennings Co-Chairpersons: Prof Nelson Lee & Srey Viseth Horm (Institute Pasteur de Cambodia) Carolina Chapel Hill) (US) (Canterbury Health Laboratories & University of Otago) (New A/Prof Aeron Hurt (Cambodia) Zealand) ƒ "Human And Non-human Influenza Surveillance In ƒ "Enterovirus D68, cause of severe respiratory disease ƒ “Treatment options for influenza virus infections” ƒ “GABRIEL study: case-control pneumonia Uganda From 2008 To 2014 - A One Health in children and association with acute flaccid paralysis [Invited Speaker] multicenter pilot study” [Invited Speaker] Approach" [ASN038] cases, Norway 2014" [ASN059] Prof Nelson Lee (Chinese University of Hong Kong) Dr Glaucia Paranhos Baccalà (Fondation Merieux) Derrick Mimbe (Makerere University Walter Reed Karoline Bragstad (Norwegian Institute of Public Health) (Hong Kong) (France) Project) (Uganda) (Norway) ƒ “Influenza antivirals - resistance and new ƒ “Aetiology of childhood pneumonia: experience from compounds” [Invited Speaker] the PERCH study” [Invited Speaker] ƒ “Clinical Severity of Human Infections of Avian ƒ "Enterovirus D68 and Other Enterovirus Genotypes A/Prof Aeron Hurt (Peter Doherty Institute for Infection Prof David Murdoch (University of Otago) (New Influenza A(H7N9) Across Three Epidemics in Identified in South African Patients Hospitalized with and Immunity) (Australia) Zealand) Mainland China” [ASN220] Severe Acute Respiratory Illness, 2009-2011" ƒ “Safety And Pharmacokinetics In Healthy Volunteers ƒ “Influenza Virus RNA In Aerosols In Patient Peng Wu (University of Hong Kong) (Hong Kong) [ASN057] Of The Anti-RSV Antiviral AK0529” [ASN062] Rooms” [ASN111] Orienka Hellferscee (National Institute for Stephen Toovey (Ark Biosciences) (Switzerland) Nancy Hiu Lan Leung (The University of Hong Kong) Communicable Diseases) (South Africa) (Hong Kong) ƒ “Haemophilus haemolyticus: differentiation from ƒ "A novel nontoxic antiviral compound for late ƒ ƒ "Development of an Iminosugar-Based Therapeutic “Influenza Virus And RSV ViroSpot™ Assays For NTHi and role in the respiratory tract” [ASN225] treatment of RSV and other respiratory infections" as a Broad Spectrum Antiviral" [ASN164] Direct Monitoring Of Phenotypic Resistance And Janessa Pickering (University of Western Australia) [ASN182] Virus Neutralization” [ASN131] Aruna Sampath (Unither Virology LLC) (US) (Australia) Andrej Egorov (HSC Development) (Russia) Carel Van Baalen (Viroclinics Biosciences) (Netherlands) 3:30 PM Teabreak ƒ ƒ “Therapeutic Antibodies Against Influenza A and “New Antiviral Inhibitors to Influenza 3:45 PM Venus Influenza B” [ASN204] Neuraminidase Revealed by Mass Spectrometry” Plenary V Man-Wah Tan (Genentech Inc) (US) [ASN208] “The science and practice of public health preparedness against directly transmissible respiratory Kevin Downard (University of New South Wales) pathogens” (Australia) Prof Gabriel Leung (University of Hong Kong) (Hong Kong) ƒ "Effectiveness of a Patient-Based Health Education 4:15 PM Intervention in Reducing Antibiotic Use For Acute ISIRV Annual General Meeting Upper Respiratory Tract Infections in the Private Sector Primary Care Setting in Singapore" [ASN048] 5:00 PM Jupiter Room Mercury Room Magdalene Lee (Yong Loo Lin School of Medicine) Bioinformatics Workshop (Singapore) ƒ 11:45 AM Mercury Room Live Demo on Virus Pathogen Resource and Influenza Research Database Lunch Session on MERS-CoV Poster Session II with Authors (J. Craig Venter Institute) (US) Chairperson: A/Prof Vernon Lee (National University of Singapore) (Singapore) (Networking Drinks) ƒ Live Demo on FluSurver in Global Initiative for ƒ “MERS: history and options for intervention” Sharing All Influenza Data (GISAID) Prof Ab Osterhaus (University of Veterinary Medicine Hannover, Foundation) (Germany) (A*STAR Bioinformatics Institute) (Singapore) ƒ “Epidemiology and Transmission of MERS” 7:00 PM End of Day 2 Dr Maria Van Kerkhove (Institut Pasteur) (France) ƒ “Unravelling the key drivers of MERS-CoV transmission” A/Prof Simon Cauchemez (Institut Pasteur) (France) ƒ "MERS CoV Outbreak in South Korea" A/Prof Yeon-Sook Kim (Chungnam National University Hospital) (S. Korea) ƒ "Results of povidone-iodine against Ebola, MERS, SARS and Influenza confirms new model virus, MVA virus, in EN14476 testing standard" A/Prof Maren Eggers (Laboratory Enders & Partners Stuttgart) (Germany) Day 3 (Friday, 4 September 15) 08:30 AM Venus 1:45 PM Venus I/II Venus III Plenary VI Special Track Parallel Session 10 “The World's Response to Ebola” “Updates on Respiratory Diseases for Policy Makers “Respiratory Pathogen Co-infections (Viral-bacterial Dame Barbara Stocking (Murray Edwards College, Cambridge) (UK) – Part 2” and Viral-viral Interactions)” 09:00 AM Plenary VII Chairperson: Prof Peter Horby Co-Chairpersons: Dr Jon McCullers & “Disease modelling to inform outbreak control” (University of Oxford) (UK) Prof Dennis Metzger Prof Neil Ferguson (Imperial College London) (UK) ƒ “Enterovirus D68 in 2014 – what happened in ƒ “Glycosylation of the influenza virus HA mediates 09:30 AM Teabreak Europe” [Invited Speaker] severity of secondary bacterial pneumonia” [Invited 10:00 AM Venus I/II Venus III Dr Pasi Penttinen (European Centre for Disease Speaker] Prevention and Control) (Sweden) Dr Jon McCullers (University of Tennessee Health Science Special Track Parallel Session 9 Center & Le Bonheur Children’s Hospital) (US) “Updates on Respiratory Diseases for Policy Makers “Modelling the Spread of Respiratory Pathogens” ƒ ƒ – Part 1” “Antimicrobial Resistance: Impact on Respiratory “Synergy Between Influenza Virus and Tract Infections” Pneumococcus” [Invited Speaker] Chairperson: Prof Paul A. Tambyah Chairperson: A/Prof Simon Cauchemez (National University of Singapore) (Singapore) (Institut Pasteur) (France) Dr Hsu Li Yang (Mount Elizabeth Novena Hospital) Prof Dennis Metzger (Albany Medical College) (US) (Singapore) ƒ “International collaborative networks for the study of ƒ “Use of a Multi-Strain SIR Model May Allow ƒ “One Health Preparedness and Interventions for ƒ "The Impact Of HIV On The Burden And Severity emerging respiratory infections” Advance Forecasting of Seasonal Influenza Pandemic Influenza” Of Influenza Illness In Malawian Adults: The BASH- Prof Peter Horby (University of Oxford) (UK) Epidemics” [ASN014] FLU Study" [ASN133] Mike Jackson (Group Health Cooperative) (US) Dr Ruben Donis (US Centers for Disease Control and Prevention) (US) Antonia Ho (Malawi-Liverpool-Wellcome Trust Clinical ƒ “Vaccine Preventable Respiratory Diseases” ƒ "Using Simple Mathematical Models to Understand Research Programme) (Malawi) Prof Leo Yee Sin (Tan Tock Seng Hospital) (Singapore) the Within-Host Dynamics of Influenza A Virus ƒ ƒ Infection: From Theory to Clinical Implications" “Bat-borne Zoonotic Respiratory Pathogens: How "Household Transmission Of Influenza Virus From [ASN106] Much Do We Know?” HIV-infected And HIV-uninfected Index Cases, South Africa, 2013-2014" [ASN166] Christoforos Hadjichrysanthou (Imperial College Prof Wang Linfa (Duke-NUS Medical School) London) (UK) (Singapore) Akhona Tshangela (National Institute for Communicable Diseases) (South Africa) ƒ “Respiratory diseases surveillance and preparedness ƒ "Global Contact Matrices For The Socio- ƒ ƒ in Indonesia” Demographic Spread Of Infectious Diseases" “Public Health Emergencies: Security & Ethics” “Irregular Seasonality of Influenza-like Illness in a Tropical Urban Setting” [ASN212] Prof Tjandra Yoga Aditama (Indonesian Ministry of [ASN154] Dr Voo Teck Chuan (National University of Singapore) Health) (Indonesia) Kiesha Prem (Saw Swee Hock School of Public Health) (Singapore) Maciej Boni (Oxford University Clinical Research Unit) (Singapore) (Viet Nam) 3:45 PM Teabreak ƒ “Tackling TB, Influenza and MERS in Singapore” ƒ "Assessing School Closure in Urban Singapore Using A/Prof Jeffrey Cutter (Singapore Ministry of Health) the GeoDEMOS Individual Based Modelling 4:00 PM Venus (Singapore) Platform" [ASN146] Plenary VIII Joel Koo (Saw Swee Hock School of Public Health) “How do we detect and respond to the next emerging respiratory infection?” (Singapore) Prof David Heymann (Public Health England) (UK) ƒ “Impact and cost-effectiveness of interventions” ƒ "Individual and population trajectories of influenza 4:30 PM Awards Presentation & Closing Remarks A/Prof Vernon Lee (National University of Singapore) antibody titers over multiple seasons in tropical 4:45 PM End of Day 3 (Singapore) Singapore" [ASN151] Alex Cook (National University of Singapore) (Singapore) 12:00 NN Mercury Room Lunch Session on Vaccines Against Influenza Chairperson: A/Prof Gavin Smith (Duke-NUS Medical School) (Singapore) ƒ "Seasonality of Influenza in Tropical and Subtropical Asia: Implications for Vaccination Timing" Dr Siddhartha Saha (US Centers for Disease Control and Prevention, India Office) (India) ƒ "Influenza B Virus Epidemiology and Burden in Asia Pacific: The Role of Quadrivalent Vaccines" Prof Ben Cowling (University of Hong Kong) (Hong Kong) ƒ "Seasonal influenza vaccine policy and implementation in Asia Pacific Countries: challenges and way forward" Prof John Tam (Hong Kong Polytechnic University) (Hong Kong)