Recognition of Cytoplasmic RNA Results in Cathepsin-Dependent Inflammasome Activation and in Human Macrophages This information is current as of October 2, 2021. Johanna Rintahaka, Niina Lietzén, Tiina Öhman, Tuula A. Nyman and Sampsa Matikainen J Immunol 2011; 186:3085-3092; Prepublished online 21 January 2011;

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Supplementary http://www.jimmunol.org/content/suppl/2011/01/24/jimmunol.100205 Material 1.DC1 http://www.jimmunol.org/ References This article cites 57 articles, 18 of which you can access for free at: http://www.jimmunol.org/content/186/5/3085.full#ref-list-1

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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2011 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology

Recognition of Cytoplasmic RNA Results in Cathepsin-Dependent Inflammasome Activation and Apoptosis in Human Macrophages

Johanna Rintahaka,* Niina Lietze´n,† Tiina O¨ hman,† Tuula A. Nyman,† and Sampsa Matikainen* dsRNA is an important pathogen-associated molecular pattern that is primarily recognized by cytosolic pattern-recognition receptors of the innate-immune system during virus infection. This recognition results in the activation of inflammasome- associated caspase-1 and apoptosis of infected cells. In this study, we used high-throughput proteomics to identify secretome, the global pattern of secreted , in human primary macrophages that had been activated through the cytoplasmic dsRNA- recognition pathway. The secretome analysis revealed cytoplasmic dsRNA-recognition pathway-induced secretion of several exosome-associated proteins, as well as basal and dsRNA-activated secretion of lysosomal protease cathepsins and cysteine pro- Downloaded from tease inhibitors (cystatins). Inflammasome activation was almost completely abolished by cathepsin inhibitors in response to dsRNA stimulation, as well as encephalomyocarditis virus and vesicular stomatitis virus infections. Interestingly, Western blot analysis showed that the mature form of cathepsin D, but not cathepsin B, was secreted simultaneously with IL-18 and inflam- masome components ASC and caspase-1 in cytoplasmic dsRNA-stimulated cells. Furthermore, small interfering RNA-mediated silencing experiments confirmed that cathepsin D has a role in inflammasome activation. Caspase-1 activation was followed by proteolytic processing of caspase-3, indicating that inflammasome activation precedes apoptosis in macrophages that had recog- http://www.jimmunol.org/ nized cytoplasmic RNA. Like inflammasome activation, apoptosis triggered by dsRNA stimulation and virus infection was effectively blocked by cathepsin inhibition. In conclusion, our results emphasize the importance of cathepsins in the innate immune response to virus infection. The Journal of Immunology, 2011, 186: 3085–3092.

nnate immune reaction against viral infection begins with endolysosomal compartments of human macrophages (4). In ad- recognition of the virus by specific pattern-recognition re- dition to TLRs, viral RNA is detected by cytoplasmic RIG-I–like ceptors (PRRs) (1). Macrophages are the central players of receptors (RLRs), such as RIG-I and MDA-5 (5, 6). RIG-I detects I by guest on October 2, 2021 innate immunity, and their PRRs detect the presence of pathogen- ssRNA bearing 59 triphosphate and/or short dsRNA molecules associated molecular patterns (PAMPs) and damage-associated mo- with certain sequence or nucleotide preferences (7–9), whereas lecular patterns (DAMPs) (2, 3). This recognition results in pro- MDA-5 is specialized to detect long dsRNA strands (.1kbin duction of antiviral and proinflammatory cytokines, recruitment of length) (10, 11). In macrophages, activation of RIG-I and MDA-5 other inflammatory cells, and, often, apoptosis of the virus-infected induces strong antiviral cytokine response, and recent data also cell. A successful innate-immune reaction also provides a firm connect RLRs to the activation of apoptosis of virus-infected cells basis for the activation of adaptive-immune responses. (12, 13). Several cytoplasmic and membrane-bound PRRs participate in IL-1b and IL-18 are important proinflammatory cytokines that innate-immune recognition of virus infection. TLR8 and TLR3 are produced during virus infection (13–15). IL-1b and IL-18 are detect endocytosed ssRNA or dsRNA molecules, respectively, in synthesized as immature forms: pro–IL-1b and pro–IL-18. Cys- teine protease caspase-1 cleaves these proforms to biologically *Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, active equivalents that are secreted via unconventional - 00250 Helsinki, Finland; and †Protein Chemistry Research Group, Institute of Bio- secretion pathways (16, 17). In parallel, caspase-1 is activated technology, University of Helsinki, 00014 Helsinki, Finland by cytosolic PRRs in a protein complex called inflammasome Received for publication June 21, 2010. Accepted for publication December 15, (18). NLRP3-inflammasome is the most studied caspase-1–acti- 2010. vating molecular platform; it is activated by various heterogeneous This work was supported by grants from the Research Council for Biosciences and DAMPs and PAMPs. The DAMPs include, for example, extra- Environment of the Academy of Finland, the Sigrid Juselius Foundation, and the Helsinki Graduate Program in Biotechnology and Molecular Biology. cellular ATP and crystalline monosodium urate (19, 20). In ad- Address correspondence and reprint requests to Dr. Sampsa Matikainen, Unit of Excel- dition to these endogenous stimuli, NLRP3-inflammasome is acti- lence for Immunotoxicology, Finnish Institute of Occupational Health, Topeliuksenkatu vated by exogenous stimuli, including asbestos, silica, aluminum 41 a A, 00250 Helsinki, Finland. E-mail address: sampsa.matikainen@ttl.fi adjuvant (21, 22), fungal toxins (23), b-glucans (24), and viral The online version of this article contains supplemental material. infections (25–27). Because these activators are chemically and Abbreviations used in this article: CatIII, cathepsin inhibitor III; DAMP, damage- structurally different, they probably are indirectly recognized by associated molecular pattern; EMCV, encephalomyocarditis virus; MOI, multiplicity of infection; PAMP, pathogen-associated molecular pattern; poly-IC, polyinosinic- the NLRP3-inflammasome. It is more likely that they activate in- polycytidylic acid; poly-IC-t, transfected polyinosinic-polycytidylic acid; PRR, flammasome by inducing changes in endogenous molecules that pattern-recognition receptor; RLR, RIG-I–like receptor; t-Bid, truncated form of are then recognized as danger signals (28). Potassium efflux and Bid; VSV, vesicular stomatitis virus. production of reactive oxygen species are common features as- Copyright Ó 2011 by The American Association of Immunologists, Inc. 0022-1767/11/$16.00 sociated with NLRP3-inflammasome activation, and it was re- www.jimmunol.org/cgi/doi/10.4049/jimmunol.1002051 3086 CATHEPSIN-DEPENDENT ACTIVATION OF INFLAMMASOME, APOPTOSIS cently shown that thioredoxin-interacting protein links oxidative Amicon Ultra-15 centrifugal filter devices, with a cut-off of 10,000 nom- stress to inflammasome activation (29, 30). inal m.w. limit (Millipore, Bedford, MA). Equal volumes of the concen- Cathepsins are lysosomal proteases that have many immuno- trated cell-culture media were separated on 15% SDS-PAGE. Western blot analysis for total-cell lysates and secreted proteins was carried out as logical activities. Cathepsin B and D are functionally closely re- described earlier (13). Primary Abs were purchased as follows: ASC lated and are the most abundant in this protein family (31–33). polyclonal Ab from Millipore; caspase p20 from Sigma-Aldrich; caspase-3 Maturation of these proteases proceeds through several steps. p19/17 and Bid from Cell Signaling Technology (Danvers, MA); caspase-1 Mature cathepsin B is found as a single-chain form (29 kDa) and p10 (C-20) and cathepsin B from Calbiochem, and cathepsin D (C-20) from Santa Cruz Biotechnology (Santa Cruz, CA). To confirm equal as a two-chain form (25 and 4 kDa) of active enzyme (34). Active loading and transfer onto membranes between the samples, membranes cathepsin D is produced through two successive cleavages of were stripped in 0.2 M NaOH for 5 min, washed in PBS-Tween 0.05% preproenzyme, resulting in formation of a two-chain mature en- three times, and stained with ready-to-use SYPRO Ruby Protein Blot zyme (14-kDa L chain and 34-kDa H chain) in lysosomes (33). Stain, according to the manufacturer’s instructions (Sigma-Aldrich). The Recently, cytoplasmic leakage of cathepsin B was associated with major basally expressed protein band is shown as a loading control. inflammasome activation (29). Secretome characterization We studied the role of cathepsins in the innate-immune re- For secretome characterization, cell-culture supernatants were first col- sponse to cytoplasmic dsRNA in human macrophages. We provide lected and concentrated with Amicon Ultra-15 centrifugal filter devices evidence that cathepsins have a central role in the activation (Millipore), as above, followed by protein purification using a 2-D Clean-Up of inflammasome and apoptosis in response to the cytoplasmic- Kit (GE Healthcare, Pittsburgh, PA). Next, proteins were separated using recognition pathway. SDS-PAGE and visualized with silver staining. For protein identification, whole gel lanes were cut into 30 pieces of equal size, proteins were in-gel

digested with trypsin, and the resulting peptides were analyzed by nanoLC- Downloaded from MS/MS, as described previously (35). The liquid chromatography-tandem Materials and Methods Human macrophages, cell stimulations, and viruses Human macrophages were differentiated from isolated blood monocytes of healthy blood donors obtained from the Finnish Red Cross Blood Transfusion Service (Helsinki, Finland), as described previously (14).

Macrophages were transfected with a mimetic of dsRNA, polyinosinic- http://www.jimmunol.org/ polycytidylic acid (poly-IC), at 10 mg/ml (Sigma-Aldrich, St. Louis, MO) using Lipofectamine 2000 transfection reagent (Invitrogen Life Techno- logies, Paisley, U.K.), according to the manufacturer’s instructions. Vesic- ular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV) were used at a multiplicity of infection (MOI) of 1, and were described pre- viously (35). Cathepsin B inhibitor Ca-074 Me ([L-3-trans-(propylcarba- moyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline methyl ester), cathepsin inhibitor III (CatIII; Z-Phe-Gly-NHO-Bz-pOMe), and cysteine protease inhibitor Est [(2S,3S)-trans-epoxysuccinyl-L-laucylamodo-3-methylbutane ethyl ester] (also known as E-64d) were purchased from Calbiochem (San Diego, CA). Each sample was obtained and pooled from three separate by guest on October 2, 2021 blood donors, and the results are representatives of three independently and similarly done experiments.

Small interfering RNA experiments After 5 d of cell culture in 12-well plates, macrophages were transfected with 100 nM nontargeting control siRNA (AllStars Negative Control siRNA, Qiagen, Hilden, Germany) and with 50 nM each of two cathepsin D siRNAs (final concentration = 100 nM) (Qiagen) by using HiPerFect Transfection Reagent (Qiagen), according to the manufacturer’s instruction. After 4 h of siRNA treatment, fresh macrophage media were added to the cells. On the following day, the cells were left unstimulated or were transfected with poly-IC for 8 h, after which the cell-culture supernatants were collected, and total proteins were isolated for ELISA and Western blot analyses, respectively.

Quantitative real-time PCR Total RNAwas isolated using an RNeasy Plus Mini Kit (Qiagen) and reverse transcribed with a High Capacity cDNA Reverse kit (Applied Biosystems, Foster City, CA), according to the manufacturers’ instructions. Quantitative real-time PCR was performed with an ABI PRISM 7500 Sequence Detection System applying TaqMan chemistry and Predeveloped TaqMan assay primers and probes (Applied Biosystems) and PerfeCTa qPCR FastMix (Quanta Biosciences, Gaithersburg, MD). The Sequence detector system version 1.4 software was used to develop the real-time PCR data (Applied Biosystems). The relative -expression differences were calculated with the comparative ΔΔCt method, as described earlier (36). The results are expressed as relative units, which is a fold change in FIGURE 1. Inflammasome activation precedes apoptosis in human that is normalized to an endogenous reference gene (18S macrophages activated through the cytoplasmic dsRNA-recognition path- rRNA) and is relative to nontemplate control containing molecular-grade way. Human primary macrophages were stimulated with Lipofectamine water instead of a cDNA sample. alone or in complex with poly-IC-t at 10 mg/ml for the indicated times, after which cell-culture media were collected for IL-18 ELISA measurements (A), Western blot analysis and total-cell lysates (B) and concentrated cell-culture media (C) were pre- Total-cell lysates were prepared as previously described (13). To analyze pared for Western blot analysis with Abs against IL-18, caspase-1 p10 and secreted proteins, cell-culture media were collected and concentrated with p20, ASC, and caspase-3 p19/17. The Journal of Immunology 3087

FIGURE 2. Secretome characterization of macro- phages activated through the cytoplasmic dsRNA- recognition pathway. A, Human macrophages were stimulated with Lipofectamine alone or in complex with poly-IC-t for 6 and 18 h. Then, cell-culture supernatants were concentrated, and proteins were precipitated, separated using SDS-PAGE, and visual- ized with silver staining. For protein identification, whole gel lanes were cut into 30 pieces of equal size, proteins were in-gel digested with trypsin, and the resulting peptides were analyzed by nanoLC-MS/MS. After 6 h of stimulation, we identified 219 and 291 proteins from control and poly-IC-t samples, respec- tively; after 18 h stimulation, we identified 167 and 424 proteins from control and poly-IC-t samples,

respectively. The Venn diagrams show the overlap Downloaded from between protein identification in control and dsRNA- stimulated samples, as well as the overlap in dsRNA- stimulated samples with different time points. The identified proteins included several Ras-related pro- teins (B), as well as cathepsins and cystatins (C). http://www.jimmunol.org/

mass spectrometry data were searched with in-house Mascot version 2.2 IL-18 secretion at 3 h after transfection, and the greatest levels of through ProteinPilot 3.0 interface against the SwissProt database (version IL-18 were seen at 12 and 18 h after stimulation (Fig. 1A). In 56.12). The search criteria for Mascot searches were human-specific tax- accordance with ELISA data, Western blot analysis of intracel-

onomy, trypsin digestion with one missed cleavage allowed, carbamido- by guest on October 2, 2021 methyl modification of cysteine as a fixed modification, and oxidation of lular proteins showed a progressive decrease in constitutively pro- methionine as a variable modification. All of the reported protein identi- duced pro–IL-18, as well as accumulation of biologically active fications were statistically significant (p , 0.05). forms of 18-kDa IL-18 and caspase-1 p10 beginning at 3 h after cytoplasmic dsRNA stimulation (Fig. 1B). Obvious intracellular Apoptosis assay formation of activated caspase-3, caspase-3 p19/17, and its The percentage of apoptotic cells was assayed with APOPercentage Ap- cleavage product IL-18 p16/15 was seen at 6 h after stimulation optosis Assay, according to the manufacturer’s guidelines (Biocolor Life Science Assays, County Antrim, U.K.). Photographs were taken with an Olympus DP70 Digital microscope camera, connected to an Olympus IX71 light microscope, and using software DP Controller (version 2.2.1.227) and DP Manager (2.2.1.195) (Center Valley, PA). The stained and unstained cells were manually counted, and the percentage of apo- ptotic cells was calculated.

ELISA measurements The concentrations of secreted IL-18 were analyzed by ELISA, according to the manufacturers’ instructions (Human Medical and Biological Labora- tories, Nagoya, Japan; Bender MedSystems, Vienna, Austria).

Results Inflammasome activation precedes apoptosis in human macrophages during innate-immune recognition of dsRNA We previously showed that cytoplasmic dsRNA recognition results in activation of inflammasome and apoptosis in human macro- phages (13). These events are associated with caspase-1– and caspase-3–mediated processing of pro–IL-18 to biologically active FIGURE 3. Secretion of cathepsin B and D in response to dsRNA (IL-18 p18) and inactive (IL-18 p15/16) forms of this cytokine, transfection. Human macrophages were stimulated with Lipofectamine respectively. To analyze the kinetics of inflammasome activation, alone or in complex with cytoplasmic dsRNA (poly-IC-t) at 10 mg/ml for poly-IC, a mimetic of dsRNA, was transfected into of 1, 3, 6, 12, or 18 h, after which cell lysates (A) and concentrated cell human macrophages, and IL-18 concentration was measured from culture media (B) were prepared for Western blot analysis with Abs against cell-culture media with ELISA. Cytoplasmic dsRNA induced cathepsin B and D. 3088 CATHEPSIN-DEPENDENT ACTIVATION OF INFLAMMASOME, APOPTOSIS with dsRNA (Fig. 1B). Two isoforms of ASC, the central com- Secretome characterization of macrophages activated through ponent of inflammasomes, were constitutively present in human cytoplasmic dsRNA-recognition pathway macrophages, and the expression of both isoforms was slightly Most proteins are secreted through a conventional protein-secre- enhanced in response to dsRNA transfection (Fig. 1B). tion pathway. These proteins contain N-terminal leader signal pep- In addition to processing of proinflammatory cytokines, inflam- tides that direct their transport to the plasma membrane through masome activation is associated with the secretion of its central the endoplasmic reticulum–Golgi pathway (37). Our current and components. To characterize dsRNA-induced inflammasome ac- previous data showed that inflammasome-associated caspase-1 is tivation further, we collected cell-culture supernatants, concen- activated in response to the cytosolic dsRNA-recognition pathway trated them, and performed Western blot analysis of extracellular in human macrophages. Keller et al. (38) showed that active proteins. In accordance with the presented data (Fig. 1A,1B), cyto- caspase-1 is a regulator of unconventional protein secretion of plasmic dsRNA elicited secretion of IL-18 p18, caspase-1 p20, leaderless proteins. To get a global overview of dsRNA-induced and ASC 6 h after stimulation (Fig. 1C). In conclusion, our re- protein secretion in macrophages, we used a combination of pro- sults showed that cytoplasmic dsRNA-induced inflammasome tein separation by SDS-PAGE followed by high-throughput pro- activation precedes apoptosis: caspase-1 activation and IL-18 se- tein identification using liquid chromatography-tandem mass cretion occurred earlier than did activation of caspase-3 and for- spectrometry. At 6 h, we identified 219 and 291 proteins from cell- mation of biologically inactive IL-18 fragments. culture supernatants of control and dsRNA-stimulated macro- Downloaded from http://www.jimmunol.org/

FIGURE 4. Cathepsins are essential for inflamma- some activation in response to cytoplasmic dsRNA stimulation. Human macrophages were left untreated or were treated with Ca-074 Me (25 mM), Est (50 or by guest on October 2, 2021 150 mM), or CatIII (50 or 150 mM) for 0.5 h before poly-IC-t stimulation for 8 h, after which cell-culture media and total cell lysates were collected. A, C, and D, IL-18 secretion was analyzed with ELISA. B, Concentrated cell-culture media were prepared for Western blot analysis with caspase-1 p20- and ASC- specific Abs. E and F, The cells were preincubated with or without Ca-074 Me (20 mM) for 0.5 h before cytoplasmic dsRNA stimulation. Total RNA was extracted at 8 h, and the expression of IFN-b and IL-29 was analyzed with quantitative RT-PCR, as described in Materials and Methods. G and H, Human primary macrophages were subjected to control and cathepsin D specific-siRNAs (100 nM) for 24 h, after which the cells were stimulated or not with cytoplasmic dsRNA for 8 h. Subsequently, cell-culture media were col- lected, and total protein lysates were prepared for IL-18 ELISA measurement and Western blot analysis with cathepsin B- and cathepsin D-specific Abs, re- spectively. The Journal of Immunology 3089 phages, respectively (Fig. 2A, Supplemental Tables I, II). At 18 h dramatically prevented secretion of biologically active forms of after dsRNA transfection, we detected 424 proteins from cell- IL-18 (Fig. 4A), ASC, and caspase-1 p20 in response to dsRNA culture supernatants compared with 167 proteins from control-cell stimulation (Fig. 4B). Similarly, Est and CatIII clearly decreased supernatants (Fig. 2A, Supplemental Tables III, IV). This shows dsRNA-induced IL-18 secretion in human macrophages (Fig. 4C, that activation of the cytoplasmic RNA-recognition pathway 4D). To study whether the antiviral cytokine response is regulated clearly induces protein secretion by 6 h, with more robust protein by cathepsins, macrophages were transfected with dsRNA in the secretion at 18 h. Our data showed that dsRNA stimulation of absence or presence of Ca-074 Me for 8 h, after which RNA was macrophages activates conventional and unconventional protein- extracted for quantitative RT-PCR analysis. Ca-074 Me had little secretion pathways. The unconventionally secreted proteins detec- effect on IFN-b and IL-29 mRNA expression in response to ted at 18 h after dsRNA stimulation included cystatin A, galectin-3, dsRNA stimulation (Fig. 4E,4F). IL-1R antagonist, macrophage migration inhibitory factor, and We used the siRNA technique to study the specific role of ca- thioredoxin (38, 39). Interestingly, dsRNA stimulation of macro- thepsin D in inflammasome activation. The human primary mac- phages also activated secretion of several exosome-associated rophages were treated with control siRNA and cathepsin D-specific proteins, including , ADP ribosylation factor 4, clathrin, heat siRNAs for 24 h, after which the cells were left unstimulated or shock proteins, , integrins, Ras-related proteins, , were stimulated with cytoplasmic dsRNA for 8 h. Silencing of and 14-3-3 proteins (40). Ras-related proteins secreted in response cathepsin D reduced cytoplasmic dsRNA-induced IL-18 secretion to dsRNA stimulation included Rab-1A, Rab-7a, Rab-10, Rab11B, (Fig. 4G). Western blot analysis confirmed that cathepsin D pro- Rab13, and Rap-1b (Fig. 2B). Furthermore, the identified proteins tein expression was strongly decreased in cathepsin D siRNA- contained several lysosomal proteins, including cathepsin B, D, S, treated macrophages, whereas cathepsin B protein expression was and Z (Fig. 2C). Cathepsin B was identified at 18 h after dsRNA not affected (Fig. 4H). In conclusion, our results suggested that Downloaded from stimulation, whereas was identified only from the con- cathepsins are crucial for efficient inflammasome activation, but trol samples. Cathepsins D and S were identified from cell-culture not for the expression of antiviral cytokines, in response to cyto- supernatants collected from control and dsRNA-stimulated mac- plasmic dsRNA stimulation in human macrophages. rophages. In addition to cathepsins, secretion of cystatins, a family Cathepsins are required for the progression of apoptosis of cysteine protease inhibitors (41), was seen (Fig. 2C). Secretion of cystatin A and B was detected at 6 and 18 h after dsRNA stim- In addition to inflammasome activation, cathepsins are involved http://www.jimmunol.org/ ulation. In contrast to cystatins A and B, cystatin C was also found in programmed cell death (apoptosis) (32, 44). We previously in the cell-culture supernatants of control cells. showed that the cytoplasmic dsRNA-recognition pathway acti- vates caspase-3 (13). We used the APOPercentage assay to further Secretion of cathepsin B and D in response to dsRNA demonstrate the activation of apoptosis in dsRNA-treated macro- transfection phages. The assay clearly demonstrated activation of apoptosis in Secretome analysis suggested major changes in secretion of macrophages that were transfected with dsRNA at 18 h (Fig. 5A). cathepsins and their regulators in macrophages activated through the cytoplasmic dsRNA-recognition pathway. To characterize their by guest on October 2, 2021 regulation in response to dsRNA stimulation in more detail, ca- thepsin B and D protein expression and secretion were analyzed in human macrophages by Western blotting. In the intracellular protein fraction, two mature forms of cathepsin B (29 and 25 kDa) were detected in control and cytoplasmic dsRNA-stimulated cells (Fig. 3A). There was a minor decrease in the levels of both forms of cathepsin B beginning at 3 h after cytoplasmic dsRNA stimu- lation. With cathepsin D, a clear decrease in 52-kDa procathepsin D was observed by 3 h after dsRNA transfection, and the intermediate-sized 46-kDa form was seen at 6 and 12 h after dsRNA stimulation. Mature 34-kDa cathepsin D was constantly present in the intracellular fraction, and dsRNA stimulation had no effect on its levels. In the extracellular-protein fraction, proca- thepsin D (52 kDa) was constitutively secreted in human primary macrophages, and dsRNA transfection had little effect on its secretion (Fig. 3B). Secretion of mature cathepsin B and interme- diate-sized 46-kDa cathepsin D occurred at 12 h after dsRNA transfection. Interestingly, secretion of mature 34-kDa cathepsin D into extracellular medium was seen 6 h after dsRNA stimulation (Fig. 3B). Importantly, the secretion of mature 34-kDa cathepsin D was simultaneous with the secretion of inflammasome components FIGURE 5. Cathepsins are required for the progression of apoptosis in ASC and caspase-1 (Fig. 1C). dsRNA-stimulated macrophages. Human macrophages were stimulated in the presence or absence of Ca-074 Me (25 mM) for 0.5 h and then left Cathepsins are essential for inflammasome activation untreated or treated with cytoplasmic dsRNA for 18 h and stained with APOPercentage Apoptosis Assay. A, Representative photographs of control Inflammasome activation has been connected to cytoplasmic (upper panel) and dsRNA-transfected (lower panel) cells (original magni- leakage of cathepsins in response to crystalline structures and fication 3100). B, The apoptotic (purple) and non-apoptotic cells were microbial infections (42, 43). Thus, we next analyzed the possible counted, and the percentage of apoptotic cells was calculated. C and D,The role of cathepsins in cytoplasmic dsRNA-induced inflammasome cells were left unexposed or were exposed to Ca-074 Me and poly-IC-t for 8 activation and antiviral cytokine response with cathepsin inhib- h, as above, and total protein lysates were prepared for Western blot analysis itors Ca-074 Me, a Ca-074–derivate Est, and CatIII. Ca-074 Me with caspase-3 p19/17 and Bid-specific Abs. 3090 CATHEPSIN-DEPENDENT ACTIVATION OF INFLAMMASOME, APOPTOSIS

Furthermore, Ca-074 Me significantly reduced the percentage their recognition of viruses relies on PRRs. PRRs detect dsRNA, of apoptotic cells (from 45 to 13%) during cytoplasmic dsRNA which is the most important PAMP formed during viral infection. stimulation (Fig. 5B). Similarly, Western blot analysis showed In the present work, we used a high-throughput proteomics ap- that Ca-074 Me clearly inhibited cytoplasmic dsRNA-induced proach to characterize secretome, the global pattern of secreted pro- caspase-3 activation, the hallmark of apoptosis, as well as com- teins, of macrophages activated through the cytoplasmic dsRNA- pletely inhibited dsRNA-induced formation of the truncated var- recognition pathway. The proteomic analysis revealed that dsRNA iant of Bid (t-Bid), which promotes apoptosis by permeating the stimulation of macrophages activates conventional and uncon- outer mitochondrial membrane with other proapoptotic proteins, ventional protein-secretion pathways in human macrophages. such as Bax and/or Bad (32) (Fig. 5C,5D). Especially, exosome-associated proteins were enriched in cell- culture supernatants of macrophages that were transfected with Cathepsins are essential for inflammasome activation and dsRNA. Secretome data also revealed secretion of lysosomal ca- apoptosis triggered by EMCV and VSV infection thepsin proteases and cysteine protease inhibitors (cystatins) in A Picornaviridae EMCV and a Rhabdoviridae VSV are detected macrophages that were activated through the cytoplasmic RNA- by MDA-5 and RIG-I, respectively (7). These RLR-dependent recognition pathway. Finally, we provide evidence that cathe- cytoplasmic RNA-recognition pathways are connected to inflam- psins are essential for inflammasome activation and apoptosis in masome activation and apoptosis (12, 13, 45). To study whether response to dsRNA stimulation and viral infection. cathepsins are important for inflammasome activation and apo- IL-1b and IL-18 are proinflammatory cytokines that are es- ptosis in response to RNA virus infection, macrophages were left sential for the initiation and maintenance of inflammation (16). untreated or were treated with Ca-074 Me for 0.5 h. After this, the IL-1b and IL-18 lack N-terminal leader signal peptides; thus, cells were left uninfected or were infected with EMCV or VSV at they are released from macrophages via an unconventional protein- Downloaded from an MOI of 1 for 8 or 16 h, and IL-18 secretion and activation of secretion pathway (46). Cysteine protease caspase-1 processes apoptosis were studied, respectively. Ca-074 Me inhibited EMCV- their proforms into their biologically active equivalents in a cyto- and VSV-induced IL-18 secretion (Fig. 6A,6B). Similarly, Ca-074 plasmic molecular structure called inflammasome (18). After this Me clearly abolished EMCV- and VSV-induced caspase-3 acti- processing step, the biologically active forms of IL-1b and IL-18 vation and formation of t-Bid (Fig. 6C,6D). In conclusion, our are secreted by poorly defined mechanisms. The molecular com- results showed that activation of apoptosis during viral infections position of the activated inflammasome varies, depending on the http://www.jimmunol.org/ is dependent on cathepsins. virus that infects the cell, but it contains at least caspase-1 and a member of a pyrin domain family protein ASC. Picornaviruses, Discussion such as EMCV, and long-cytoplasmic dsRNA stretches activate Innate immunity against viruses includes production of antiviral caspase-1 and NLRP3-inflammasome via MDA-5, whereas VSV and proinflammatory cytokines and induction of apoptosis. Mac- triggers caspase-1 independently of NLRP3 via RIG-I (45). In all rophages are the central players in the innate-immune system, and cases, the specific mechanisms that activate inflammasomes are by guest on October 2, 2021

FIGURE 6. Cathepsins are essential for in- flammasome activation and apoptosis during EMCV and VSV infection. A and B,Human macrophages were left untreated or were treated with Ca-074 Me (25 mM) for 0.5 h before in- fection with EMCV or VSV at an MOI of 1 for 8 h. After 8 h of infection, cell-culture super- natants were collected, and secretion of IL-18 was measured by ELISA. C and D, The cells were left untreated or were treated with Ca-074 Me (45 mM) for 0.5 h before infection with EMCV or VSV at an MOI of 1 for 16 h. Then total-cell lysates were prepared for Western blot analysis with caspase-3 p19/17 and Bid-specific Abs. The Journal of Immunology 3091 not fully understood. Our data showed that a mimetic of long- cysteine protease inhibitors, including cystatin A, B, and C) (41). cytoplasmic dsRNA, transfected poly-IC (poly-IC-t), activates Our data showed that cystatins are secreted simultaneously with inflammasome, which was observed as the appearance of active cathepsins in macrophages that are activated through the dsRNA- caspase-1 and intracellular accumulation of biologically active IL- recognition pathway. Thus, cystatins may bind to cathepsin B and 18. This all coincided with the onset of IL-18 secretion (Fig. 1). limit its extralysosomal functions. Interestingly, More importantly, caspase-3 was activated with delayed kinetics does not encode aspartate-specific protease inhibitors, which could compared with caspase-1 (Fig. 1B), indicating that inflammasome antagonize functions of cathepsin D (55); moreover, cathepsin D activation preceded the initiation of apoptosis in macrophages is able to inactivate cystatins (56, 57). Importantly, we found that that had been activated through the cytosolic dsRNA-recognition cathepsin D was secreted earlier than cathepsin B in dsRNA- pathway. stimulated cells. Thus, it may be possible that the prior release of Membrane transfer is a common mode of intercellular com- cathepsin D ensures cathepsin B-mediated inflammasome activa- munication between immune cells. Exosome secretion is a form of tion and apoptosis. The balance between the actions of cystatins membrane transfer that is activated by various environmental and lysosomal leakage of cathepsins is likely important for the signals, including TLR activation and/or stress conditions (40). progression of both of these innate-immune reactions. Our secretome analysis revealed secretion of several exosome- In our experiments, inflammasome activation in response to associated proteins, including actin, ADP ribosylation factor 4, dsRNA stimulation, as well as EMCV and VSV infection, was clathrin, heat shock proteins, histones, integrins, Ras-related pro- completely abolished by cathepsin inhibitor Ca-074 Me. Ca-074 teins, tubulin, and 14-3-3 proteins, in response to dsRNA stimu- Me is a cell-permeable and irreversible inhibitor of intracellular lation. Of these Ras-related proteins, Rab-1A, Rab-7a, Rab-10, cathepsins, and its primary target is cathepsin B. In addition to Rab11B, Rab13, and Rap-1b are especially interesting because Ca-074 Me, a Ca-074-derivate Est and cathepsin inhibitor CatIII Downloaded from they are involved in protein transport and secretion (47). In- clearly reduced inflammasome activation. We found that secretion terestingly, secretome analysis showed that Rab-1A, Rab-13, and of the mature form of cathepsin D, but not that of cathepsin B, Rap-1b secretion was already seen at 6 h after dsRNA trans- occurred simultaneously with inflammasome components ASC fection, and it was associated with secretion of inflammasome and caspase-1. Interestingly, silencing of cathepsin D with siRNAs components. It was recently shown that another member of the reduced dsRNA-induced IL-18 secretion (Fig. 4G), demonstrating RabGTPase family (Rab39a) binds caspase-1 and is involved in a role for cathepsin D in inflammasome activation. It is likely that http://www.jimmunol.org/ caspase-1–dependent secretion of IL-1b in response to LPS cathepsins have redundant functions, and knockdown of a single stimulation (48). Clearly, further studies are needed to clarify the cathepsin does not result in complete inhibition of inflammasome role of Ras-related proteins in IL-1b and IL-18 secretion during activation, as was also shown in our study. In conclusion, our re- viral infections. sults suggest an important role for cathepsins in the innate-immune Lysosomes are acidic organelles in which different metabolic response to virus infection, but further studies are required to end products and contents of late endosomes and phagosomes are show the precise role of different cathepsins in inflammasome degraded. In addition to inflammasome activation, moderate ly- activation and apoptosis. sosomal damage leads to apoptosis. It is possible that the acidic by guest on October 2, 2021 environment and the action of hydrolases produce apoptotic sig- Acknowledgments nals that induce apoptosis when released into cytoplasm. Cathep- We thank Dr. Jesper Melchjorsen for kindly providing EMCV and VSV. sins are the best-studied class of lysosomal hydrolases. Cathepsin B and D are closely related cysteine- and aspartate-specific pro- Disclosures teases, respectively, and they were shown to promote programmed The authors have no financial conflicts of interest. cell death (apoptosis) (44, 49). Reactive oxygen species-mediated translocation of cathepsins from lysosomes to cytoplasm is an early event in apoptosis; it occurs before loss of mitochondrial References membrane potential, release of cytochrome c, and activation of 1. Wilkins, C., and M. Gale, Jr. 2010. Recognition of viruses by cytoplasmic sensors. Curr. Opin. Immunol. 22: 41–47. the apoptotic caspase cascade (50, 51). Our results showed that in- 2. Takeuchi, O., and S. Akira. 2010. Pattern recognition receptors and in- hibition of cathepsin activity with Ca-074 Me clearly reduced the flammation. 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Goodbourn, pletely inhibited formation of t-Bid in response to dsRNA mimetic and R. E. Randall. 2004. The V proteins of paramyxoviruses bind the IFN- and viral stimuli (Figs. 5D,6C,6D). t-Bid promotes mitochondrial inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta pro- outer membrane permeabilization and the mitochondrial apoptosis moter. Proc. Natl. Acad. Sci. USA 101: 17264–17269. 7. Kato, H., O. Takeuchi, S. Sato, M. Yoneyama, M. Yamamoto, K. Matsui, pathway, as described above (52). Our results suggested that ly- S. Uematsu, A. Jung, T. Kawai, K. J. Ishii, et al. 2006. Differential roles of sosomal cathepsins function upstream of mitochondrial damage MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441: 101– to activate apoptosis during virus infection. 105. 8. Pichlmair, A., O. Schulz, C. P. Tan, T. I. Naslund, P. Liljestrom, F. Weber, and E. Cathepsin B and D have versatile immunological functions S. C. Reis. 2006. RIG-I-mediated antiviral responses to single-stranded RNA (i.e., they are involved in MHC class II-mediated Ag presentation bearing 59-phosphates. Science 314: 997–1001. 9. Hornung, V., J. Ellegast, S. Kim, K. Brzozka, A. Jung, H. Kato, H. Poeck, S. and TLR signaling) (53, 54). Cathepsin research has been com- Akira, K. K. Conzelmann, M. Schlee, et al. 2006. 59-Triphosphate RNA is the plicated by their functional redundancy, as exemplified by ca- ligand for RIG-I. Science 314: 994–997. thepsin knockout studies in mice (31, 53). Under normal condi- 10. Gitlin, L., W. Barchet, S. Gilfillan, M. Cella, B. Beutler, R. A. Flavell, M. S. Diamond, and M. Colonna. 2006. Essential role of mda-5 in type I IFN tions, lysosomal proteases are scarcely found outside cells, and responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis their activities are controlled intracellularly (i.e., by endogenous picornavirus. Proc. Natl. Acad. Sci. USA 103: 8459–8464. 3092 CATHEPSIN-DEPENDENT ACTIVATION OF INFLAMMASOME, APOPTOSIS

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Mascot Search Results

User : Email : Search title : Database : SwissProt 57.12 (513877 sequences; 180750753 residues) Taxonomy : Homo sapiens (human) (20329 sequences) Timestamp : 12 Feb 2010 at 15:18:50 GMT Enzyme : Trypsin Fixed modifications : Carbamidomethyl (C) Variable modifications : Oxidation (M) Mass values : Monoisotopic Protein Mass : Unrestricted Peptide Mass Tolerance : ± 0.2 Da Fragment Mass Tolerance: ± 0.2 Da Max Missed Cleavages : 1 Instrument type : ESI-QUAD-TOF Number of queries : 68593 Protein hits : P13645|K1C10_HUMAN , type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 P35908|K22E_HUMAN Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 P35527|K1C9_HUMAN Keratin, type I cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 P04264|K2C1_HUMAN Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 P02533|K1C14_HUMAN Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 P08779|K1C16_HUMAN Keratin, type I cytoskeletal 16 OS=Homo sapiens GN=KRT16 PE=1 SV=4 P13647|K2C5_HUMAN Keratin, type II cytoskeletal 5 OS=Homo sapiens GN=KRT5 PE=1 SV=3 P04259|K2C6B_HUMAN Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 P02768|ALBU_HUMAN Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 P02538|K2C6A_HUMAN Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 Q04695|K1C17_HUMAN Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 P13646|K1C13_HUMAN Keratin, type I cytoskeletal 13 OS=Homo sapiens GN=KRT13 PE=1 SV=4 O95678|K2C75_HUMAN Keratin, type II cytoskeletal 75 OS=Homo sapiens GN=KRT75 PE=1 SV=2 Q7Z3Y7|K1C28_HUMAN Keratin, type I cytoskeletal 28 OS=Homo sapiens GN=KRT28 PE=1 SV=1 P60709|ACTB_HUMAN Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 Q86Y46|K2C73_HUMAN Keratin, type II cytoskeletal 73 OS=Homo sapiens GN=KRT73 PE=1 SV=1 P02649|APOE_HUMAN Apolipoprotein E OS=Homo sapiens GN=APOE PE=1 SV=1 P08727|K1C19_HUMAN Keratin, type I cytoskeletal 19 OS=Homo sapiens GN=KRT19 PE=1 SV=3 Q7Z3Y8|K1C27_HUMAN Keratin, type I cytoskeletal 27 OS=Homo sapiens GN=KRT27 PE=1 SV=1 P61626|LYSC_HUMAN Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 Q01546|K22O_HUMAN Keratin, type II cytoskeletal 2 oral OS=Homo sapiens GN=KRT76 PE=1 SV=1 Q7Z3Z0|K1C25_HUMAN Keratin, type I cytoskeletal 25 OS=Homo sapiens GN=KRT25 PE=1 SV=1 Q7RTS7|K2C74_HUMAN Keratin, type II cytoskeletal 74 OS=Homo sapiens GN=KRT74 PE=1 SV=2 Q5XKE5|K2C79_HUMAN Keratin, type II cytoskeletal 79 OS=Homo sapiens GN=KRT79 PE=1 SV=1 Q7Z3Y9|K1C26_HUMAN Keratin, type I cytoskeletal 26 OS=Homo sapiens GN=KRT26 PE=1 SV=2 P81605|DCD_HUMAN Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 Q2M2I5|K1C24_HUMAN Keratin, type I cytoskeletal 24 OS=Homo sapiens GN=KRT24 PE=1 SV=1 P08670|VIME_HUMAN OS=Homo sapiens GN=VIM PE=1 SV=4 Q99456|K1C12_HUMAN Keratin, type I cytoskeletal 12 OS=Homo sapiens GN=KRT12 PE=1 SV=1 P19013|K2C4_HUMAN Keratin, type II cytoskeletal 4 OS=Homo sapiens GN=KRT4 PE=1 SV=4 Q6S8J3|POTEE_HUMAN POTE domain family member E OS=Homo sapiens GN=POTEE PE=1 SV=3 P31025|LCN1_HUMAN Lipocalin-1 OS=Homo sapiens GN=LCN1 PE=1 SV=1 P12035|K2C3_HUMAN Keratin, type II cytoskeletal 3 OS=Homo sapiens GN=KRT3 PE=1 SV=2 P12036|NFH_HUMAN heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 Q92764|KRT35_HUMAN Keratin, type I cuticular Ha5 OS=Homo sapiens GN=KRT35 PE=2 SV=4 P05783|K1C18_HUMAN Keratin, type I cytoskeletal 18 OS=Homo sapiens GN=KRT18 PE=1 SV=2 O76013|KRT36_HUMAN Keratin, type I cuticular Ha6 OS=Homo sapiens GN=KRT36 PE=1 SV=1 P36222|CH3L1_HUMAN Chitinase-3-like protein 1 OS=Homo sapiens GN=CHI3L1 PE=1 SV=2 P08729|K2C7_HUMAN Keratin, type II cytoskeletal 7 OS=Homo sapiens GN=KRT7 PE=1 SV=4 Q86YZ3|HORN_HUMAN Hornerin OS=Homo sapiens GN=HRNR PE=1 SV=2 P02787|TRFE_HUMAN Serotransferrin OS=Homo sapiens GN=TF PE=1 SV=2 P04075|ALDOA_HUMAN Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2 Q3SY84|K2C71_HUMAN Keratin, type II cytoskeletal 71 OS=Homo sapiens GN=KRT71 PE=1 SV=2 P60174|TPIS_HUMAN Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=2 Q14CN4|K2C72_HUMAN Keratin, type II cytoskeletal 72 OS=Homo sapiens GN=KRT72 PE=1 SV=2 Q7Z794|K2C1B_HUMAN Keratin, type II cytoskeletal 1b OS=Homo sapiens GN=KRT77 PE=1 SV=2 P14780|MMP9_HUMAN Matrix metalloproteinase-9 OS=Homo sapiens GN=MMP9 PE=1 SV=3 P63104|1433Z_HUMAN 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 P06396|GELS_HUMAN OS=Homo sapiens GN=GSN PE=1 SV=1 Q8N1N4|K2C78_HUMAN Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=1 SV=2 P06733|ENOA_HUMAN Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 Q5D862|FILA2_HUMAN -2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 P13796|PLSL_HUMAN Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=5 P04406|G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 P07355|ANXA2_HUMAN A2 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 P11142|HSP7C_HUMAN Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 P14618|KPYM_HUMAN Pyruvate kinase isozymes M1/M2 OS=Homo sapiens GN=PKM2 PE=1 SV=4 P00338|LDHA_HUMAN L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 P12814|ACTN1_HUMAN Alpha--1 OS=Homo sapiens GN=ACTN1 PE=1 SV=2 P54652|HSP72_HUMAN Heat shock-related 70 kDa protein 2 OS=Homo sapiens GN=HSPA2 PE=1 SV=1 P09467|F16P1_HUMAN Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=4 P17066|HSP76_HUMAN Heat shock 70 kDa protein 6 OS=Homo sapiens GN=HSPA6 PE=1 SV=2 P25774|CATS_HUMAN Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 Q9BYX7|ACTBM_HUMAN Beta-actin-like protein 3 OS=Homo sapiens GN=ACTBL3 PE=1 SV=1 P07737|PROF1_HUMAN -1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 P29401|TKT_HUMAN Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 O43933|PEX1_HUMAN Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 P08238|HS90B_HUMAN Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4 Q562R1|ACTBL_HUMAN Beta-actin-like protein 2 OS=Homo sapiens GN=ACTBL2 PE=1 SV=2 O43707|ACTN4_HUMAN Alpha-actinin-4 OS=Homo sapiens GN=ACTN4 PE=1 SV=2 P31946|1433B_HUMAN 14-3-3 protein beta/alpha OS=Homo sapiens GN=YWHAB PE=1 SV=3 P52790|HXK3_HUMAN Hexokinase-3 OS=Homo sapiens GN=HK3 PE=1 SV=2 P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5

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Q13231|CHIT1_HUMAN Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 P61981|1433G_HUMAN 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 P07195|LDHB_HUMAN L-lactate dehydrogenase B chain OS=Homo sapiens GN=LDHB PE=1 SV=2 P62988|UBIQ_HUMAN Ubiquitin OS=Homo sapiens GN=RPS27A PE=1 SV=1 P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3 P68871|HBB_HUMAN Hemoglobin subunit beta OS=Homo sapiens GN=HBB PE=1 SV=2 P28072|PSB6_HUMAN Proteasome subunit beta type-6 OS=Homo sapiens GN=PSMB6 PE=1 SV=4 P17900|SAP3_HUMAN Ganglioside GM2 activator OS=Homo sapiens GN=GM2A PE=1 SV=4 Q6ZMR3|LDH6A_HUMAN L-lactate dehydrogenase A-like 6A OS=Homo sapiens GN=LDHAL6A PE=2 SV=1 P08758|ANXA5_HUMAN OS=Homo sapiens GN=ANXA5 PE=1 SV=2 Q9H299|SH3L3_HUMAN SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 P41219|PERI_HUMAN OS=Homo sapiens GN=PRPH PE=1 SV=2 P17661|DESM_HUMAN OS=Homo sapiens GN=DES PE=1 SV=3 P21333|FLNA_HUMAN -A OS=Homo sapiens GN=FLNA PE=1 SV=4 P26038|MOES_HUMAN Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 P02751|FINC_HUMAN Fibronectin OS=Homo sapiens GN=FN1 PE=1 SV=3 P40121|CAPG_HUMAN Macrophage-capping protein OS=Homo sapiens GN=CAPG PE=1 SV=1 P09486|SPRC_HUMAN SPARC OS=Homo sapiens GN=SPARC PE=1 SV=1 P13797|PLST_HUMAN Plastin-3 OS=Homo sapiens GN=PLS3 PE=1 SV=4 P31146|COR1A_HUMAN Coronin-1A OS=Homo sapiens GN=CORO1A PE=1 SV=4 P52566|GDIR2_HUMAN Rho GDP-dissociation inhibitor 2 OS=Homo sapiens GN=ARHGDIB PE=1 SV=3 P01023|A2MG_HUMAN Alpha-2-macroglobulin OS=Homo sapiens GN=A2M PE=1 SV=2 P01009|A1AT_HUMAN Alpha-1-antitrypsin OS=Homo sapiens GN=SERPINA1 PE=1 SV=3 O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens GN=IDH1 PE=1 SV=2 P23528|COF1_HUMAN Cofilin-1 OS=Homo sapiens GN=CFL1 PE=1 SV=3 P00918|CAH2_HUMAN Carbonic anhydrase 2 OS=Homo sapiens GN=CA2 PE=1 SV=2 P49913|CAMP_HUMAN Cathelicidin antimicrobial peptide OS=Homo sapiens GN=CAMP PE=1 SV=1 P60900|PSA6_HUMAN Proteasome subunit alpha type-6 OS=Homo sapiens GN=PSMA6 PE=1 SV=1 Q96PE2|ARHGH_HUMAN Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 Q14533|KRT81_HUMAN Keratin, type II cuticular Hb1 OS=Homo sapiens GN=KRT81 PE=1 SV=2 P02786|TFR1_HUMAN Transferrin receptor protein 1 OS=Homo sapiens GN=TFRC PE=1 SV=2 P40925|MDHC_HUMAN Malate dehydrogenase, cytoplasmic OS=Homo sapiens GN=MDH1 PE=1 SV=4 P61769|B2MG_HUMAN Beta-2-microglobulin OS=Homo sapiens GN=B2M PE=1 SV=1 Q3B8N2|LEG9B_HUMAN Galectin-9B OS=Homo sapiens GN=LGALS9B PE=2 SV=3 Q6DKI2|LEG9C_HUMAN Galectin-9C OS=Homo sapiens GN=LGALS9C PE=2 SV=1 P02788|TRFL_HUMAN Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 P05109|S10A8_HUMAN Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 P37802|TAGL2_HUMAN Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 P78386|KRT85_HUMAN Keratin, type II cuticular Hb5 OS=Homo sapiens GN=KRT85 PE=1 SV=1 Q05639|EF1A2_HUMAN Elongation factor 1-alpha 2 OS=Homo sapiens GN=EEF1A2 PE=1 SV=1 P19971|TYPH_HUMAN Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2 P60660|MYL6_HUMAN light polypeptide 6 OS=Homo sapiens GN=MYL6 PE=1 SV=2 Q8TF72|SHRM3_HUMAN Protein Shroom3 OS=Homo sapiens GN=SHROOM3 PE=1 SV=1 P10599|THIO_HUMAN Thioredoxin OS=Homo sapiens GN=TXN PE=1 SV=3 P62805|H4_HUMAN H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 O00299|CLIC1_HUMAN Chloride intracellular channel protein 1 OS=Homo sapiens GN=CLIC1 PE=1 SV=4 P62937|PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens GN=PPIA PE=1 SV=2 P28065|PSB9_HUMAN Proteasome subunit beta type-9 OS=Homo sapiens GN=PSMB9 PE=1 SV=2 P15259|PGAM2_HUMAN Phosphoglycerate mutase 2 OS=Homo sapiens GN=PGAM2 PE=1 SV=3 Q9H4G4|GAPR1_HUMAN Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens GN=GLIPR2 PE=1 SV=3 Q58FF8|H90B2_HUMAN Putative heat shock protein HSP 90-beta 2 OS=Homo sapiens GN=HSP90AB2P PE=1 SV=2 P58546|MTPN_HUMAN Myotrophin OS=Homo sapiens GN=MTPN PE=1 SV=2 O75366|AVIL_HUMAN Advillin OS=Homo sapiens GN=AVIL PE=1 SV=2 P09327|VILI_HUMAN Villin-1 OS=Homo sapiens GN=VIL1 PE=1 SV=4 P67936|TPM4_HUMAN alpha-4 chain OS=Homo sapiens GN=TPM4 PE=1 SV=3 P62258|1433E_HUMAN 14-3-3 protein epsilon OS=Homo sapiens GN=YWHAE PE=1 SV=1 P06703|S10A6_HUMAN Protein S100-A6 OS=Homo sapiens GN=S100A6 PE=1 SV=1 P25311|ZA2G_HUMAN Zinc-alpha-2-glycoprotein OS=Homo sapiens GN=AZGP1 PE=1 SV=1 Q14019|COTL1_HUMAN Coactosin-like protein OS=Homo sapiens GN=COTL1 PE=1 SV=3 P22392|NDKB_HUMAN Nucleoside diphosphate kinase B OS=Homo sapiens GN=NME2 PE=1 SV=1 P06454|PTMA_HUMAN Prothymosin alpha OS=Homo sapiens GN=PTMA PE=1 SV=2 P69905|HBA_HUMAN Hemoglobin subunit alpha OS=Homo sapiens GN=HBA1 PE=1 SV=2 Q08043|ACTN3_HUMAN Alpha-actinin-3 OS=Homo sapiens GN=ACTN3 PE=1 SV=2 P35609|ACTN2_HUMAN Alpha-actinin-2 OS=Homo sapiens GN=ACTN2 PE=1 SV=1 P01034|CYTC_HUMAN Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1 O00391|QSOX1_HUMAN Sulfhydryl oxidase 1 OS=Homo sapiens GN=QSOX1 PE=1 SV=3 Q5VSK2|MRC1L_HUMAN Macrophage mannose receptor 1-like protein 1 OS=Homo sapiens GN=MRC1L1 PE=2 SV=1 Q5T749|KPRP_HUMAN Keratinocyte proline-rich protein OS=Homo sapiens GN=KPRP PE=1 SV=1 P35241|RADI_HUMAN OS=Homo sapiens GN=RDX PE=1 SV=1 P26447|S10A4_HUMAN Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1 Q06830|PRDX1_HUMAN Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 P00491|PNPH_HUMAN Purine nucleoside phosphorylase OS=Homo sapiens GN=NP PE=1 SV=2 Q58FF7|H90B3_HUMAN Putative heat shock protein HSP 90-beta-3 OS=Homo sapiens GN=HSP90AB3P PE=5 SV=1 P09960|LKHA4_HUMAN Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 O75083|WDR1_HUMAN WD repeat-containing protein 1 OS=Homo sapiens GN=WDR1 PE=1 SV=4 P31944|CASPE_HUMAN Caspase-14 OS=Homo sapiens GN=CASP14 PE=1 SV=2 P08123|CO1A2_HUMAN Collagen alpha-2(I) chain OS=Homo sapiens GN=COL1A2 PE=1 SV=6 Q9NZK5|CECR1_HUMAN Adenosine deaminase CECR1 OS=Homo sapiens GN=CECR1 PE=1 SV=2 P05090|APOD_HUMAN Apolipoprotein D OS=Homo sapiens GN=APOD PE=1 SV=1 P14136|GFAP_HUMAN Glial fibrillary acidic protein OS=Homo sapiens GN=GFAP PE=1 SV=1 P23381|SYWC_HUMAN Tryptophanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=WARS PE=1 SV=2 P16035|TIMP2_HUMAN Metalloproteinase inhibitor 2 OS=Homo sapiens GN=TIMP2 PE=1 SV=2 P78417|GSTO1_HUMAN Glutathione S-transferase omega-1 OS=Homo sapiens GN=GSTO1 PE=1 SV=2 P55072|TERA_HUMAN Transitional endoplasmic reticulum ATPase OS=Homo sapiens GN=VCP PE=1 SV=4 P09382|LEG1_HUMAN Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 Q01518|CAP1_HUMAN Adenylyl cyclase-associated protein 1 OS=Homo sapiens GN=CAP1 PE=1 SV=4 Q96QA5|GSDMA_HUMAN Gasdermin-A OS=Homo sapiens GN=GSDMA PE=2 SV=3 O15511|ARPC5_HUMAN Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens GN=ARPC5 PE=1 SV=3 Q9H4B7|TBB1_HUMAN Tubulin beta-1 chain OS=Homo sapiens GN=TUBB1 PE=1 SV=1

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P07339|CATD_HUMAN Cathepsin D OS=Homo sapiens GN=CTSD PE=1 SV=1 P11021|GRP78_HUMAN 78 kDa glucose-regulated protein OS=Homo sapiens GN=HSPA5 PE=1 SV=2 Q15648|MED1_HUMAN Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens GN=MED1 PE=1 SV=4 P01876|IGHA1_HUMAN Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 P00558|PGK1_HUMAN Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 PE=1 SV=3 Q96K76|UBP47_HUMAN Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens GN=USP47 PE=1 SV=2 P28066|PSA5_HUMAN Proteasome subunit alpha type-5 OS=Homo sapiens GN=PSMA5 PE=1 SV=3 P61916|NPC2_HUMAN Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 P15153|RAC2_HUMAN Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens GN=RAC2 PE=1 SV=1 P60763|RAC3_HUMAN Ras-related C3 botulinum toxin substrate 3 OS=Homo sapiens GN=RAC3 PE=1 SV=1 Q08379|GOGA2_HUMAN Golgin subfamily A member 2 OS=Homo sapiens GN=GOLGA2 PE=1 SV=2 P59998|ARPC4_HUMAN Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens GN=ARPC4 PE=1 SV=3 P31949|S10AB_HUMAN Protein S100-A11 OS=Homo sapiens GN=S100A11 PE=1 SV=2 P02654|APOC1_HUMAN Apolipoprotein C-I OS=Homo sapiens GN=APOC1 PE=1 SV=1 Q99497|PARK7_HUMAN Protein DJ-1 OS=Homo sapiens GN=PARK7 PE=1 SV=2 P05089|ARGI1_HUMAN Arginase-1 OS=Homo sapiens GN=ARG1 PE=1 SV=2 P16070|CD44_HUMAN CD44 antigen OS=Homo sapiens GN=CD44 PE=1 SV=2 Q8TER0|SNED1_HUMAN Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens GN=SNED1 PE=1 SV=2 P37837|TALDO_HUMAN Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 Q5D1E8|ZC12A_HUMAN Ribonuclease ZC3H12A OS=Homo sapiens GN=ZC3H12A PE=1 SV=1 Q96CB9|NSUN4_HUMAN Putative methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 PE=1 SV=2 P59665|DEF1_HUMAN Neutrophil defensin 1 OS=Homo sapiens GN=DEFA1 PE=1 SV=1 Q9Y490|TLN1_HUMAN -1 OS=Homo sapiens GN=TLN1 PE=1 SV=3 P15336|ATF2_HUMAN Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens GN=ATF2 PE=1 SV=4 P02452|CO1A1_HUMAN Collagen alpha-1(I) chain OS=Homo sapiens GN=COL1A1 PE=1 SV=4 P11413|G6PD_HUMAN Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens GN=G6PD PE=1 SV=4 P60903|S10AA_HUMAN Protein S100-A10 OS=Homo sapiens GN=S100A10 PE=1 SV=2 P63218|GBG5_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens GN=GNG5 PE P15924|DESP_HUMAN OS=Homo sapiens GN=DSP PE=1 SV=3 Q04917|1433F_HUMAN 14-3-3 protein eta OS=Homo sapiens GN=YWHAH PE=1 SV=4 P27348|1433T_HUMAN 14-3-3 protein theta OS=Homo sapiens GN=YWHAQ PE=1 SV=1 P06744|G6PI_HUMAN Glucose-6-phosphate isomerase OS=Homo sapiens GN=GPI PE=1 SV=4 Q9NQP4|PFD4_HUMAN Prefoldin subunit 4 OS=Homo sapiens GN=PFDN4 PE=1 SV=1 O00626|CCL22_HUMAN C-C motif chemokine 22 OS=Homo sapiens GN=CCL22 PE=1 SV=1 O95359|TACC2_HUMAN Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens GN=TACC2 PE=1 SV=3 Q02413|DSG1_HUMAN Desmoglein-1 OS=Homo sapiens GN=DSG1 PE=1 SV=1 Q00610|CLH1_HUMAN Clathrin heavy chain 1 OS=Homo sapiens GN=CLTC PE=1 SV=5 O43150|ASAP2_HUMAN Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens GN=AS Q9UBR2|CATZ_HUMAN Cathepsin Z OS=Homo sapiens GN=CTSZ PE=1 SV=1 Q15050|RRS1_HUMAN Ribosome biogenesis regulatory protein homolog OS=Homo sapiens GN=RRS1 PE=1 SV=2 Q9NW13|RBM28_HUMAN RNA-binding protein 28 OS=Homo sapiens GN=RBM28 PE=1 SV=3 Q96R72|OR4K3_HUMAN Olfactory receptor 4K3 OS=Homo sapiens GN=OR4K3 PE=3 SV=3 P05107|ITB2_HUMAN Integrin beta-2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 P08571|CD14_HUMAN Monocyte differentiation antigen CD14 OS=Homo sapiens GN=CD14 PE=1 SV=2 Q9H0J4|QRIC2_HUMAN Glutamine-rich protein 2 OS=Homo sapiens GN=QRICH2 PE=1 SV=1 P28838|AMPL_HUMAN Cytosol aminopeptidase OS=Homo sapiens GN=LAP3 PE=1 SV=3 Q9NZT1|CALL5_HUMAN -like protein 5 OS=Homo sapiens GN=CALML5 PE=1 SV=2 Q07617|SPAG1_HUMAN Sperm-associated antigen 1 OS=Homo sapiens GN=SPAG1 PE=1 SV=3 Q9UP38|FZD1_HUMAN Frizzled-1 OS=Homo sapiens GN=FZD1 PE=1 SV=2 Q13029|PRDM2_HUMAN PR domain zinc finger protein 2 OS=Homo sapiens GN=PRDM2 PE=1 SV=3 O95202|LETM1_HUMAN LETM1 and EF-hand domain-containing protein 1, mitochondrial OS=Homo sapiens GN=LETM1 PE=1 S Q9UPQ9|TNR6B_HUMAN Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens GN=TNRC6B PE=1 SV=4 Q0VG06|FP100_HUMAN Fanconi anemia-associated protein of 100 kDa OS=Homo sapiens GN=FAAP100 PE=1 SV=2 P10451|OSTP_HUMAN Osteopontin OS=Homo sapiens GN=SPP1 PE=1 SV=1 P30486|1B48_HUMAN HLA class I histocompatibility antigen, B-48 alpha chain OS=Homo sapiens GN=HLA-B PE=2 SV=1 P30504|1C04_HUMAN HLA class I histocompatibility antigen, Cw-4 alpha chain OS=Homo sapiens GN=HLA-C PE=1 SV=1 O60296|TRAK2_HUMAN Trafficking -binding protein 2 OS=Homo sapiens GN=TRAK2 PE=1 SV=2

Select Summary Report

Format As Select Summary (protein hits) Help Significance threshold p< 0.05 Max. number of hits AUTO Standard scoring %$#"! MudPIT scoring %$#"! Ions score or expect cut-off 0 Show sub-sets 0 Show pop-ups %$#"! Suppress pop-ups %$#"! Sort unassigned Decreasing Score Require bold red 

1. P13645|K1C10_HUMAN Mass: 59020 Score: 11607 Queries matched: 651 emPAI: 7.49 Keratin, type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 R.LAADDFR.L 20206 20207 20208 20209 20210 20211 20212 20213 20672 405.2299 808.4453 808.4330 0.0123 0 47 0.0011 1 R.LASYLDK.V 20569 20571 587 20584 20590 20593 594 20603 2062 24284 424.2305 846.4465 846.4447 0.0018 0 28 0.12 1 K.SEITELR.R 24282 24283 32368 466.7653 931.5160 931.3705 0.1455 0 5 20 7 K.NHEEEMK.D 32366 34206 483.7423 965.4701 965.4494 0.0207 1 10 4.5 1 R.DYSKYYK.T 34205 10544 35579 497.2549 992.4952 992.4927 0.0026 0 55 0.00018 1 K.YENEVALR.Q 35566 35568 35569 35571 35572 35574 35575 3557 35677 498.2725 994.5304 994.5123 0.0181 1 36 0.013 1 K.IKEWYEK.H 35649 35651 11413 35654 35655 35656 35657 35658 36192 502.2861 1002.5576 1002.5458 0.0119 1 41 0.0043 1 K.SEITELRR.N 36143 36144 36148 36149 11749 36153 36154 3615 37532 516.3061 1030.5976 1030.5910 0.0065 0 38 0.0083 1 R.VLDELTLTK.A 12623 37535 38610 524.7972 1047.5799 1047.5713 0.0087 1 24 0.22 1 R.LAADDFRLK.Y 38607 38609 38611 38612 39616 532.8131 1063.6117 1063.6026 0.0091 1 63 3e-005 1 R.LASYLDKVR.A 39604 39605 39606 39607 39608 39609 39610 3961 41130 545.7668 1089.5190 1089.5237 -0.0046 0 (54) 0.00024 1 K.VTMQNLNDR.L 14358 41127 41128 14359 41129 41131 14360 4113 41959 553.7641 1105.5137 1105.5186 -0.0049 0 63 2.7e-005 1 K.VTMQNLNDR.L 41958 41960 41961 41962 41963 41964 41965 419 42267 555.2549 1108.4953 1108.4825 0.0128 0 40 0.0049 1 K.DAEAWFNEK.S 42237 42238 42239 42241 42242 42243 42244 4224 42541 559.7604 1117.5062 1117.5013 0.0049 0 53 0.00026 1 K.HGNSHQGEPR.D 42540 44829 583.3018 1164.5890 1164.5775 0.0115 0 68 8.5e-006 1 R.LENEIQTYR.S 44803 44804 44805 44806 16413 44808 44809 4481 45701 594.3582 1186.7018 1186.6921 0.0096 1 41 0.0044 1 R.RVLDELTLTK.A 45695 45696 45697 45698 16985 46326 601.3203 1200.6260 1200.6098 0.0161 0 64 2e-005 1 R.QSVEADINGLR.R 17292 46318 17293 46319 46320 46321 17295 4

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47777 617.8501 1233.6856 1233.6717 0.0139 1 60 5.1e-005 1 R.LKYENEVALR.Q 47743 47751 47753 47754 47756 47757 47759 477 47942 619.3088 1236.6029 1236.5775 0.0255 1 54 0.0002 1 R.KDAEAWFNEK.S 47936 47937 47938 47940 47941 48954 631.8153 1261.6160 1261.5899 0.0262 0 98 8.5e-009 1 R.SLLEGEGSSGGGGR.G 48923 48924 48925 48926 48927 48928 4893 50701 434.2115 1299.6127 1299.5877 0.0250 1 (42) 0.0031 1 K.NHEEEMKDLR.N 50689 50690 50691 50692 5701 50693 50694 506 51318 658.7997 1315.5849 1315.5826 0.0023 1 54 0.0002 1 K.NHEEEMKDLR.N 51310 51311 51312 51313 51314 51315 51317 513 8257 453.2396 1356.6969 1356.7110 -0.0141 1 20 1.3 1 R.QSVEADINGLRR.V 52726 8258 52728 8259 8260 52729 52730 5273 52982 683.3373 1364.6600 1364.6320 0.0280 0 80 4.4e-007 1 R.SQYEQLAEQNR.K 52952 52953 52954 52955 52956 52957 52958 52 53476 691.3292 1380.6438 1380.6408 0.0030 0 115 1.3e-010 1 R.ALEESNYELEGK.I 53468 53469 53470 53471 53472 53473 53474 5 53775 695.8415 1389.6684 1389.6736 -0.0051 0 81 3.2e-007 1 K.QSLEASLAETEGR.Y 19624 19625 19626 19627 19628 53776 53777 54752 717.8969 1433.7793 1433.7626 0.0167 1 40 0.0041 1 K.IRLENEIQTYR.S 54745 54746 54747 54748 54749 10295 54750 54 55531 747.3638 1492.7131 1492.7270 -0.0139 1 78 7.5e-007 1 R.SQYEQLAEQNRK.D 55532 55533 55534 55535 55536 55537 55538 5 55578 499.2400 1494.6982 1494.6910 0.0071 1 12 2.4 1 K.SSSSGSVGESSSKGPR.Y 56089 775.3398 1548.6650 1548.6700 -0.0050 0 128 5.5e-012 1 R.SGGGGGGGGCGGGGGVSSLR.I 56086 56087 56088 56090 56091 560 57086 854.3949 1706.7753 1706.7649 0.0104 0 112 2.2e-010 1 K.GSLGGGFSSGGFSGGSFSR.G 57077 57078 57079 57080 57081 57082 58373 998.9832 1995.9519 1995.9636 -0.0117 0 111 2.5e-010 1 K.ELTTEIDNNIEQISSYK.S 59243 1041.9904 2081.9661 2081.9575 0.0086 0 136 6.5e-013 1 R.AETECQNTEYQQLLDIK.I 59242 59244 19878 738.0348 2211.0827 2211.0906 -0.0079 1 24 0.11 1 K.SKELTTEIDNNIEQISSYK.S 19887

2. P35908|K22E_HUMAN Mass: 65678 Score: 11317 Queries matched: 617 emPAI: 8.03 Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 22335 416.2547 830.4949 830.4862 0.0087 0 56 0.00017 1 R.SLVGLGGTK.S 2055 2072 2079 2083 2085 2088 2090 2091 22315 20 6504 439.2291 876.4437 876.4315 0.0122 1 23 0.69 1 R.GRGGGGGGFR.G 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 K.YEDEINK.R 30827 30828 30831 30834 8520 30836 30837 30839 30 34513 487.2705 972.5265 972.5240 0.0025 0 41 0.0046 1 K.IEISELNR.V 10825 10832 10837 10839 10841 10844 10845 10846 35641 497.7951 993.5756 993.5607 0.0149 0 66 1.4e-005 1 R.LQGEIAHVK.K 35617 35618 35619 35620 11392 35621 35622 35623 35720 498.7643 995.5140 995.5148 -0.0008 1 46 0.0012 1 R.GEHALKDAR.N 35719 35721 35722 35723 35941 501.2807 1000.5468 1000.5301 0.0167 1 25 0.2 1 K.AQEREQIK.T 35913 35917 35924 35928 35931 35936 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 K.LLEGEECR.M 36289 36290 36291 36293 36294 36295 36296 36297 37232 513.7903 1025.5660 1025.5505 0.0155 1 35 0.013 1 R.HGDSLKEIK.I 37226 37230 37233 37234 37242 12829 519.2744 1036.5342 1036.5189 0.0153 0 50 0.0023 1 R.YLDGLTAER.T 12824 37853 37854 12825 37855 12826 37856 37857 12838 519.7622 1037.5098 1037.5029 0.0069 1 38 0.0078 1 K.KYEDEINK.R 12839 37881 37994 521.2861 1040.5576 1040.5502 0.0074 0 39 0.0059 1 K.VDPEIQNVK.A 37977 37980 37982 37989 37996 38002 39767 533.7638 1065.5131 1065.5090 0.0041 1 55 0.00015 1 K.YEDEINKR.T 39764 39766 39769 39770 39771 39772 39773 39774 39825 534.7563 1067.4980 1067.4957 0.0023 0 42 0.0029 1 K.DVDNAYMIK.V 39826 39827 39828 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 40990 544.3152 1086.6158 1086.6033 0.0125 1 5 20 3 R.EQIKTLNNK.F 42094 554.2745 1106.5344 1106.5356 -0.0012 0 63 2.8e-005 1 K.AQYEEIAQR.S 42081 42083 42085 42088 42089 42090 42091 42092 42889 561.8372 1121.6598 1121.6557 0.0041 1 41 0.0049 1 R.LQGEIAHVKK.Q 42882 42885 42886 42887 42888 42890 42891 428 42986 563.2707 1124.5267 1124.5067 0.0201 1 11 4.2 6 M.SCQISCKSR.G 43005 43168 566.2618 1130.5090 1130.5026 0.0064 0 63 2.8e-005 1 R.STSSFSCLSR.H 43162 43163 43164 43165 43166 15616 43167 1561 43294 567.2917 1132.5689 1132.5546 0.0143 1 55 0.00017 1 R.KLLEGEECR.M 43273 43274 43276 43277 43278 43279 43280 43281 15762 570.2774 1138.5403 1138.5328 0.0074 0 40 0.013 1 R.DYQELMNVK.L 15761 43681 43683 15769 45933 597.3198 1192.6251 1192.6088 0.0163 0 55 0.00014 1 K.YEELQVTVGR.H 45929 45930 17095 45931 45932 17096 17097 46205 599.2915 1196.5683 1196.5422 0.0261 0 63 2.4e-005 1 K.GGSISGGGYGSGGGK.H 46198 46199 46200 46201 17199 46202 4620 46622 604.8218 1207.6291 1207.6085 0.0207 0 90 5.3e-008 1 R.TAAENDFVTLK.K 17576 46607 17577 46608 17578 17579 17580 46 48673 627.8137 1253.6129 1253.6001 0.0129 0 104 2.1e-009 1 R.GFSSGSAVVSGGSR.R 48648 48649 48651 48652 48653 48654 48655 3581 424.8217 1271.4433 1271.5421 -0.0987 1 7 12 1 -.MSCQISCKSR.G 50151 429.8855 1286.6346 1286.6037 0.0309 1 29 0.058 1 R.RSTSSFSCLSR.H 50139 18739 50140 50141 50142 50143 50144 501 51427 660.8020 1319.5894 1319.5756 0.0138 0 97 1e-008 1 R.HGGGGGGFGGGGFGSR.S 51405 51407 51408 51410 51412 51413 514 51793 665.3302 1328.6458 1328.6320 0.0138 0 73 2.6e-006 1 K.NVQDAIADAEQR.G 51784 51785 51786 51787 51788 51789 19274 51 51806 665.3746 1328.7346 1328.7187 0.0159 0 81 4.3e-007 1 R.NLDLDSIIAEVK.A 51800 51801 51802 51803 51805 51807 51808 51 51954 668.8622 1335.7098 1335.7034 0.0064 1 40 0.0047 1 R.TAAENDFVTLKK.D 51952 51953 51955 51957 51958 7430 7432 519 53263 686.3583 1370.7021 1370.7041 -0.0020 0 82 3e-007 1 K.LNDLEEALQQAK.E 19528 53264 53265 53266 53267 53792 696.3482 1390.6819 1390.6728 0.0091 1 82 2.7e-007 1 R.SKEEAEALYHSK.Y 53785 53786 53787 53788 53789 53790 53791 53 54275 470.9108 1409.7107 1409.7012 0.0095 1 31 0.031 1 R.GFSSGSAVVSGGSRR.S 54261 54262 54265 54266 54267 54268 5426 55126 730.9134 1459.8121 1459.7922 0.0199 0 102 2.9e-009 1 K.VDLLNQEIEFLK.V 55124 55125 55329 738.4114 1474.8083 1474.7780 0.0303 0 93 1.9e-008 1 R.FLEQQNQVLQTK.W 55294 55297 55299 55300 55301 19910 55302 55 56393 794.8548 1587.6951 1587.6761 0.0189 0 75 1.4e-006 1 R.GGSSSGGGYGSGGGGSSSVK.G 56388 56389 56390 56391 56392 56394 57299 870.8619 1739.7092 1739.6983 0.0109 0 145 9.6e-014 1 R.GSSSGGGYSSGSSSYGSGGR.Q 57288 57289 57290 57291 57292 57293 57308 871.3778 1740.7411 1740.7412 -0.0002 0 112 1.8e-010 1 R.GGSGGGGSISGGGYGSGGGSGGR.Y 57307 57309 57310 57311 60220 758.0190 2271.0351 2271.0325 0.0027 1 16 0.58 1 R.TSQNSELNNMQDLVEDYKK.K 60221

3. P35527|K1C9_HUMAN Mass: 62255 Score: 9316 Queries matched: 430 emPAI: 4.38 Keratin, type I cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15877 572.3275 571.3202 571.3442 -0.0240 0 0 1.6e+002 6 K.IGLGGR.G 20672 405.2299 808.4453 808.4330 0.0123 0 47 0.0011 1 R.LASYLDK.V 20569 20571 587 20584 20590 20593 594 20603 2062 21170 406.7549 811.4953 811.4916 0.0038 1 30 0.046 1 K.KGPAAIQK.N 685 21097 21159 21160 21168 29426 449.2153 896.4161 896.4062 0.0099 0 41 0.0036 1 R.MTLDDFR.I 7684 29412 7685 29413 29414 7687 29415 7688 7689 31023 457.2147 912.4147 912.4011 0.0136 0 (21) 0.44 1 R.MTLDDFR.I 31014 31015 8594 8597 31017 31018 8598 31019 859 34040 481.7542 961.4938 961.4828 0.0110 1 39 0.008 1 K.SLEDTKNR.Y 34035 34036 34038 34902 491.7240 981.4335 981.4265 0.0071 0 62 3e-005 1 R.FSSSGGGGGGGR.F 34899 34907 34909 34910 39230 530.7871 1059.5596 1059.5560 0.0035 0 41 0.0054 1 K.TLLDIDNTR.M 13507 13508 13509 13510 13511 13512 13513 1351 39653 533.2573 1064.5000 1064.4920 0.0079 0 (57) 0.00011 1 K.STMQELNSR.L 39641 39642 39643 39644 39645 39646 39647 3964 13741 533.7532 1065.4919 1065.4913 0.0006 0 (36) 0.014 1 K.FEMEQNLR.Q 13743 39766 39767 39770 39773 39774 39775 39777 40702 541.2558 1080.4971 1080.4870 0.0102 0 58 8.5e-005 1 K.STMQELNSR.L 40693 40695 40696 40697 40698 40699 40700 4070 40742 541.7553 1081.4961 1081.4862 0.0098 0 38 0.0084 1 K.FEMEQNLR.Q 40730 40731 40732 40733 40734 40735 40738 4073 41443 548.2850 1094.5555 1094.5396 0.0159 1 20 0.48 1 K.IQDWYDKK.G 42747 561.2961 1120.5775 1120.5764 0.0011 0 56 0.00013 1 R.QEYEQLIAK.N 42741 42742 15251 15252 42746 15253 42748 1525 44414 579.3074 1156.6001 1156.5836 0.0165 0 75 1.5e-006 1 R.QGVDADINGLR.Q 16225 44400 44402 16226 44404 44405 44406 1 45801 595.8100 1189.6054 1189.6013 0.0041 0 70 5.9e-006 1 R.QVLDNLTMEK.S 45802 17037 45803 17038 45804 46482 603.8049 1205.5953 1205.5962 -0.0008 0 (52) 0.0003 1 R.QVLDNLTMEK.S 46477 17456 46479 46480 46481 46483 46484 464 47599 616.8096 1231.6046 1231.5906 0.0141 0 122 3e-011 1 R.SGGGGGGGLGSGGSIR.S 47570 47573 47574 47575 47577 47578 47 47827 618.2771 1234.5395 1234.5215 0.0181 0 94 1.7e-008 1 R.FSSSSGYGGGSSR.V 47800 47802 47803 47804 47805 47806 47807 50923 654.3413 1306.6680 1306.6703 -0.0023 1 (17) 0.89 1 R.IKFEMEQNLR.Q 50924 50927 19066 51589 662.3435 1322.6724 1322.6652 0.0072 1 48 0.00065 1 R.IKFEMEQNLR.Q 51580 51581 51582 51583 51584 51585 51586 515

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52519 450.9094 1349.7065 1349.6800 0.0265 1 28 0.074 1 K.IGLGGRGGSGGSYGR.G 52508 52510 52511 52512 52513 52514 525 56366 793.8892 1585.7638 1585.7583 0.0055 0 100 3.9e-009 1 K.VQALEEANNDLENK.I 56358 56359 56360 56361 56362 56363 5636 57494 896.3620 1790.7095 1790.7205 -0.0110 0 163 1.3e-015 1 R.GGSGGSYGGGGSGGGYGGGSGSR.G 57491 57492 57493 57495 57496 5 57826 613.3220 1836.9441 1836.9581 -0.0141 0 34 0.014 1 R.HGVQELEIELQSQLSK.K 57857 926.4546 1850.8946 1850.9196 -0.0250 1 76 7.4e-007 1 K.TLNDMRQEYEQLIAK.N 57893 934.4611 1866.9076 1866.9145 -0.0070 1 (37) 0.0067 1 K.TLNDMRQEYEQLIAK.N 61205 837.3800 2509.1182 2509.1245 -0.0063 0 77 4.4e-007 1 K.EIETYHNLLEGGQEDFESSGAGK.I 61206 61207 61208 61209 67255 1075.1031 3222.2875 3222.2744 0.0131 0 75 1e-007 1 R.GGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGGGSGK.S

4. P04264|K2C1_HUMAN Mass: 66170 Score: 9285 Queries matched: 623 emPAI: 10.07 Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19681 704.3763 703.3690 703.3752 -0.0062 0 30 0.076 1 R.LDSELK.N 20149 401.7271 801.4396 801.4344 0.0051 1 24 0.28 1 R.EREQIK.S 20150 20173 402.7111 803.4076 803.4025 0.0052 0 22 0.5 1 R.SEIDNVK.K 20172 20174 20175 20176 22375 416.7508 831.4870 831.4814 0.0056 0 51 0.00063 1 K.SISISVAR.G 22367 22368 22369 22370 22371 22372 22373 22374 27851 437.7486 873.4826 873.4920 -0.0093 0 59 9.6e-005 1 R.SLVNLGGSK.S 27852 27854 27855 27856 27857 27858 27859 27860 7576 448.3191 894.6236 894.4519 0.1717 1 0 1.5e+002 4 R.RTTSSSTR.R 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 K.YEDEINK.R 30827 30828 30831 30834 8520 30836 30837 30839 30 32362 466.7591 931.5037 931.4974 0.0063 1 27 0.11 1 R.SEIDNVKK.Q 32359 32360 32361 32363 32364 32365 32366 32367 33034 473.2538 944.4930 944.4927 0.0004 1 25 0.2 1 R.GENALKDAK.N 34513 487.2705 972.5265 972.5240 0.0025 0 41 0.0046 1 K.IEISELNR.V 10825 10832 10837 10839 10841 10844 10845 10846 35804 500.2330 998.4514 998.4379 0.0135 0 50 0.00051 1 K.DVDGAYMTK.V 35787 35788 35789 35790 35791 35792 35793 35794 36579 508.2274 1014.4403 1014.4328 0.0075 0 (34) 0.025 1 K.DVDGAYMTK.V 36573 12179 36574 36575 36576 36577 36578 36580 37671 517.2733 1032.5320 1032.5087 0.0232 0 61 4.4e-005 1 R.TLLEGEESR.M 37639 37640 37641 37642 12701 37643 37644 12703 39700 533.2739 1064.5333 1064.5138 0.0195 0 64 2e-005 1 K.AQYEDIAQK.S 39654 39657 39659 39662 39663 39665 39670 39671 39767 533.7638 1065.5131 1065.5090 0.0041 1 55 0.00015 1 K.YEDEINKR.T 39764 39766 39769 39770 39771 39772 39773 39774 40075 537.3043 1072.5940 1072.5876 0.0064 1 39 0.008 1 R.LRSEIDNVK.K 40031 40034 40045 40051 40060 40063 40064 40078 41287 546.7568 1091.4990 1091.4956 0.0035 0 86 1.2e-007 1 R.GSGGGSSGGSIGGR.G 41283 41284 41285 41286 41288 41289 43011 563.2772 1124.5399 1124.5349 0.0050 0 68 8.4e-006 1 K.AEAESLYQSK.Y 42979 42984 42985 42988 42990 42991 42992 429 43055 564.2839 1126.5533 1126.5329 0.0204 1 79 6.7e-007 1 K.KDVDGAYMTK.V 43043 43045 43046 43047 43049 43050 43724 571.2653 1140.5161 1140.5121 0.0040 0 (33) 0.022 1 R.DYQELMNTK.L 43723 43725 43726 43727 43728 43729 43730 43731 43753 572.2729 1142.5313 1142.5278 0.0036 1 (54) 0.00024 1 K.KDVDGAYMTK.V 43756 43758 43759 43760 43761 43762 43765 44302 576.7910 1151.5675 1151.5458 0.0217 1 45 0.0015 1 R.NKYEDEINK.R 16151 44289 44290 44291 44292 44293 44294 44295 44396 579.2720 1156.5295 1156.5070 0.0225 0 36 0.014 1 R.DYQELMNTK.L 44389 44390 44391 44392 44393 44394 44395 45120 588.3064 1174.5983 1174.5942 0.0041 1 54 0.00022 1 R.VDQLKSDQSR.L 45119 45162 45408 590.3156 1178.6165 1178.5931 0.0234 0 64 1.9e-005 1 K.YEELQITAGR.H 45371 16776 45374 45375 16780 45376 16784 4537 49120 633.3256 1264.6367 1264.6299 0.0068 0 73 2.5e-006 1 R.TNAENEFVTIK.K 49108 49109 49110 49111 49112 49113 49114 491 49627 639.3375 1276.6604 1276.6259 0.0345 1 31 0.038 1 K.SDQSRLDSELK.N 49612 49613 49615 49616 49617 49618 49620 49 50674 650.7664 1299.5183 1299.5224 -0.0040 0 79 4.7e-007 1 K.NMQDMVEDYR.N 50675 18990 18991 50677 50681 50790 651.8677 1301.7209 1301.6939 0.0270 1 41 0.0034 1 R.NSKIEISELNR.V 50777 50797 651.8702 1301.7258 1301.7078 0.0179 0 78 6.6e-007 1 R.SLDLDSIIAEVK.A 50774 50775 50776 50778 50779 50780 50781 50 51307 658.7688 1315.5231 1315.5173 0.0058 0 (41) 0.0031 1 K.NMQDMVEDYR.N 51308 51855 666.7747 1331.5349 1331.5122 0.0227 0 (41) 0.0035 1 K.NMQDMVEDYR.N 51850 51851 51852 51853 51854 52215 670.8455 1339.6765 1339.6619 0.0146 1 78 8e-007 1 K.SKAEAESLYQSK.Y 52190 52191 52192 52193 52194 52195 52196 52 19453 679.3526 1356.6906 1356.6885 0.0021 0 61 0.00012 1 K.LNDLEDALQQAK.E 19454 19455 19457 19458 19586 692.3709 1382.7272 1382.6830 0.0442 0 71 1.2e-005 1 K.SLNNQFASFIDK.V 19584 19585 19588 19591 19593 19598 19599 1 53852 697.3707 1392.7268 1392.7249 0.0019 1 92 3e-008 1 R.TNAENEFVTIKK.D 53841 53843 53844 53845 53846 53855 53856 53 54482 711.3669 1420.7192 1420.7310 -0.0118 1 2 27 1 K.RTNAENEFVTIK.K 19912 738.3999 1474.7853 1474.7416 0.0437 0 50 0.0011 1 K.WELLQQVDTSTR.T 19905 19907 19909 55329 738.4114 1474.8083 1474.7780 0.0303 0 93 1.9e-008 1 R.FLEQQNQVLQTK.W 55294 55297 55299 55300 55301 19910 55302 55 55888 508.6015 1522.7827 1522.7813 0.0014 1 4 16 1 R.LLRDYQELMNTK.L 56464 800.4201 1598.8257 1598.8264 -0.0007 1 70 3.8e-006 1 K.NKLNDLEDALQQAK.E 14451 546.9629 1637.8668 1637.8525 0.0143 1 32 0.022 1 K.SLNNQFASFIDKVR.F 14452 14454 14455 56814 829.4023 1656.7901 1656.7856 0.0045 0 116 9.3e-011 1 R.SGGGFSSGSAGIINYQR.R 56810 56811 56812 56813 56815 57141 858.9225 1715.8304 1715.8438 -0.0134 0 119 4.3e-011 1 K.QISNLQQSISDAEQR.G 57142 57143 57144 57145 57146 57147 5714 57333 876.4127 1750.8108 1750.8195 -0.0087 1 42 0.0025 1 R.GSGGGSSGGSIGGRGSSSGGVK.S 57332 57334 57335 57336 57337 573 57404 883.3777 1764.7408 1764.7275 0.0133 0 140 3.2e-013 1 R.FSSCGGGGGSFGAGGGFGSR.S 57405 57406 58546 673.2971 2016.8695 2016.8768 -0.0073 1 24 0.092 1 R.LDSELKNMQDMVEDYR.N 58547 59211 693.9773 2078.9100 2078.9075 0.0025 1 16 0.59 1 R.GGSGGGGGGSSGGRGSGGGSSGGSIGGR.G 59210 60283 762.7210 2285.1412 2285.1175 0.0237 1 47 0.0005 1 K.AEAESLYQSKYEELQITAGR.H 60778 795.3321 2382.9744 2382.9447 0.0297 0 97 2.6e-009 1 R.GGGGGGYGSGGSSYGSGGGSYGSGGGGGGGR.G

5. P02533|K1C14_HUMAN Mass: 51872 Score: 5533 Queries matched: 353 emPAI: 3.61 Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 R.LAADDFR.T 20206 20207 20208 20209 20210 20211 20212 20213 2 20672 405.2299 808.4453 808.4330 0.0123 0 47 0.0011 1 R.LASYLDK.V 20569 20571 587 20584 20590 20593 594 20603 20624 22392 417.2251 832.4356 832.4290 0.0066 0 29 0.09 1 K.SEISELR.R 22393 2253 22395 22396 8864 460.2250 918.4354 918.4123 0.0231 0 2 1.8e+002 2 K.DYSPYFK.T 35251 494.7751 987.5357 987.5349 0.0008 1 5 19 1 K.TIEDLRNK.I 35421 495.2797 988.5449 988.5301 0.0148 1 22 0.39 1 K.SEISELRR.T 35351 35358 35359 35364 35365 35368 35370 35372 36039 501.7337 1001.4529 1001.4488 0.0041 0 47 0.0014 1 R.QFTSSSSMK.G 11701 37379 515.3034 1028.5922 1028.5866 0.0057 0 38 0.0087 1 R.VLDELTLAR.A 12476 12517 12518 12520 12521 12522 12523 37842 518.7696 1035.5246 1035.5250 -0.0004 1 9 6.5 3 K.IRDWYQR.Q 37843 37860 519.2692 1036.5239 1036.5189 0.0050 0 1 43 9 K.YETELNLR.M 39616 532.8131 1063.6117 1063.6026 0.0091 1 63 3e-005 1 R.LASYLDKVR.A 39604 39605 39606 39607 39608 39609 39610 39611 41130 545.7668 1089.5190 1089.5237 -0.0046 0 (54) 0.00024 1 K.VTMQNLNDR.L 14358 41127 41128 14359 41129 41131 14360 41133 41959 553.7641 1105.5137 1105.5186 -0.0049 0 63 2.7e-005 1 K.VTMQNLNDR.L 41958 41960 41961 41962 41963 41964 41965 4196 42007 553.7937 1105.5728 1105.5550 0.0178 0 81 4.1e-007 1 R.ISSVLAGGSCR.A 41988 41989 41990 41991 41992 41993 41994 14 42877 561.7955 1121.5764 1121.5717 0.0048 0 39 0.0067 1 R.LEQEIATYR.R 45056 586.7645 1171.5145 1171.5186 -0.0040 0 22 0.34 1 K.DAEEWFFTK.T 47058 610.8098 1219.6051 1219.5932 0.0119 0 67 1.2e-005 1 K.ASLENSLEETK.G 47057 47059 48184 621.7767 1241.5389 1241.5458 -0.0069 0 35 0.017 1 K.NHEEEMNALR.G 48793 629.7859 1257.5573 1257.5408 0.0165 0 (32) 0.032 1 K.NHEEEMNALR.G 48791 48792 49208 633.8510 1265.6875 1265.6615 0.0260 1 32 0.032 1 R.TKYETELNLR.M 49718 639.8010 1277.5874 1277.5783 0.0091 0 79 6.3e-007 1 K.GSCGIGGGIGGGSSR.I 49710 18674 49711 49712 49713 49714 4971 50733 651.3414 1300.6683 1300.6510 0.0173 0 83 2.1e-007 1 R.ALEEANADLEVK.I 50709 50710 50711 50712 50713 50714 50716 18

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52820 681.3469 1360.6792 1360.6834 -0.0042 0 101 3.8e-009 1 R.EVATNSELVQSGK.S 52817 52818 52819 19474 52821 52822 52823 5 53451 690.3605 1378.7063 1378.7204 -0.0141 1 30 0.05 1 K.TRLEQEIATYR.R 53449 54545 713.3605 1424.7063 1424.6896 0.0168 0 65 1.5e-005 1 R.APSTYGGGLSVSSSR.F 54536 54537 54539 54540 54541 54542 5454 54732 717.3641 1432.7137 1432.7157 -0.0020 1 35 0.016 1 K.ASLENSLEETKGR.Y 54734 10284 54791 719.8628 1437.7110 1437.6922 0.0188 1 31 0.034 1 R.ILNEMRDQYEK.M 54789 54790 55027 727.8588 1453.7030 1453.6871 0.0159 1 (28) 0.074 1 R.ILNEMRDQYEK.M 55021 55022 55024 55026 55028 55029 60400 770.3691 2308.0856 2308.0567 0.0289 0 17 0.5 1 R.LLEGEDAHLSSSQFSSGSQSSR.D

6. P08779|K1C16_HUMAN Mass: 51578 Score: 4625 Queries matched: 321 emPAI: 3.33 Keratin, type I cytoskeletal 16 OS=Homo sapiens GN=KRT16 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 R.LAADDFR.T 20206 20207 20208 20209 20210 20211 20212 20213 20672 405.2299 808.4453 808.4330 0.0123 0 47 0.0011 1 R.LASYLDK.V 20569 20571 587 20584 20590 20593 594 20603 2062 22392 417.2251 832.4356 832.4290 0.0066 0 13 3.6 3 R.SEVTELR.R 22393 22395 22396 8864 460.2250 918.4354 918.4123 0.0231 0 2 1.8e+002 2 K.DYSPYFK.T 35251 494.7751 987.5357 987.5349 0.0008 1 5 19 1 K.TIEDLRNK.I 35358 495.2707 988.5268 988.5301 -0.0034 1 22 0.4 1 R.SEVTELRR.V 35359 35362 35365 35367 35368 35370 35372 3537 36039 501.7337 1001.4529 1001.4488 0.0041 0 47 0.0014 1 R.QFTSSSSMK.G 11701 37379 515.3034 1028.5922 1028.5866 0.0057 0 38 0.0087 1 R.VLDELTLAR.T 12476 12517 12518 12520 12521 12522 12523 37386 515.7195 1029.4245 1029.5243 -0.0998 0 2 34 4 K.YEHELALR.Q 37842 518.7696 1035.5246 1035.5250 -0.0004 1 9 6.5 3 K.IRDWYQR.Q 37843 39616 532.8131 1063.6117 1063.6026 0.0091 1 63 3e-005 1 R.LASYLDKVR.A 39604 39605 39606 39607 39608 39609 39610 3961 41130 545.7668 1089.5190 1089.5237 -0.0046 0 (54) 0.00024 1 K.VTMQNLNDR.L 14358 41127 41128 14359 41129 41131 14360 4113 41959 553.7641 1105.5137 1105.5186 -0.0049 0 63 2.7e-005 1 K.VTMQNLNDR.L 41958 41960 41961 41962 41963 41964 41965 419 42007 553.7937 1105.5728 1105.5550 0.0178 0 81 4.1e-007 1 R.ISSVLAGGSCR.A 41988 41989 41990 41991 41992 41993 41994 14 42877 561.7955 1121.5764 1121.5717 0.0048 0 39 0.0067 1 R.LEQEIATYR.R 44391 579.2647 1156.5148 1156.4706 0.0441 0 0 49 9 R.DQYEQMAEK.N 46326 601.3203 1200.6260 1200.6099 0.0161 0 2 32 8 R.QTVEADVNGLR.R 47058 610.8098 1219.6051 1219.5932 0.0119 0 67 1.2e-005 1 K.ASLENSLEETK.G 47057 47059 48146 621.3012 1240.5878 1240.5870 0.0008 0 36 0.01 1 K.NHEEEMLALR.G 48145 48772 629.3110 1256.6073 1256.5819 0.0255 0 (21) 0.4 1 K.NHEEEMLALR.G 48803 420.5654 1258.6743 1258.6669 0.0073 1 28 0.064 1 R.TKYEHELALR.Q 2599 48837 630.7903 1259.5660 1259.5630 0.0030 0 67 9.4e-006 1 R.EVFTSSSSSSSR.Q 48834 48835 48838 48839 48841 48846 48847 49718 639.8010 1277.5874 1277.5783 0.0091 0 79 6.3e-007 1 K.GSCGIGGGIGGGSSR.I 49710 18674 49711 49712 49713 49714 497 50733 651.3414 1300.6683 1300.6510 0.0173 0 83 2.1e-007 1 R.ALEEANADLEVK.I 50709 50710 50711 50712 50713 50714 50716 1 52080 669.8493 1337.6841 1337.6575 0.0265 0 54 0.00017 1 R.APSTYGGGLSVSSR.F 52076 52078 52079 52081 52733 453.2457 1356.7152 1356.7110 0.0043 1 13 2.3 1 R.QTVEADVNGLRR.V 52739 53451 690.3605 1378.7063 1378.7204 -0.0141 1 30 0.05 1 K.TRLEQEIATYR.R 53449 53686 693.3960 1384.7775 1384.6768 0.1007 1 5 16 3 R.KNHEEEMLALR.G 53675 54137 703.3555 1404.6965 1404.6845 0.0121 0 85 1.4e-007 1 K.EVASNSELVQSSR.S 54136 54138 54732 717.3641 1432.7137 1432.7157 -0.0020 1 35 0.016 1 K.ASLENSLEETKGR.Y 54734 10284 59357 1052.4902 2102.9659 2102.9539 0.0120 0 72 1.5e-006 1 R.GQTGGDVNVEMDAAPGVDLSR.I 59431 707.3556 2119.0451 2119.0393 0.0058 1 61 2.5e-005 1 K.TEELNKEVASNSELVQSSR.S 59432 59433

7. P13647|K2C5_HUMAN Mass: 62568 Score: 3456 Queries matched: 380 emPAI: 2.77 Keratin, type II cytoskeletal 5 OS=Homo sapiens GN=KRT5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20711 405.7090 809.4035 809.4032 0.0004 0 25 0.17 1 R.QSSVSFR.S 20712 20715 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 28689 442.7295 883.4445 883.4400 0.0045 0 39 0.0059 1 R.TSFTSVSR.S 28684 28685 28686 28687 28688 28690 28691 28692 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.V 30598 30601 30603 30604 30605 30606 30607 30609 3 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 K.YEDEINK.R 30827 30828 30831 30834 8520 30836 30837 30839 30 31482 458.7649 915.5152 915.5025 0.0127 1 20 0.58 3 R.AEIDNVKK.Q 31480 32552 469.7549 937.4952 937.4869 0.0083 0 22 0.31 1 R.SLYNLGGSK.R 32547 32548 32549 32550 32553 33036 473.2575 944.5005 944.5039 -0.0034 1 33 0.038 1 R.GRLDSELR.N 9851 33035 33038 33039 33040 33048 33049 33053 3 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 K.LLEGEECR.L 36289 36290 36291 36293 36294 36295 36296 36297 36597 508.2396 1014.4646 1014.4552 0.0094 0 30 0.061 1 K.HEISEMNR.M 36598 36686 508.7729 1015.5311 1015.5298 0.0013 0 37 0.012 1 R.QLDSIVGER.G 12205 12206 36688 36689 36693 36701 36703 36704 37219 513.7346 1025.4546 1025.4488 0.0059 0 22 0.3 1 K.DVDAAYMNK.V 37440 516.2360 1030.4575 1030.4502 0.0073 0 (18) 0.94 1 K.HEISEMNR.M 37439 37562 516.7744 1031.5343 1031.5247 0.0096 1 25 0.22 1 R.TEEREQIK.T 37560 37561 37563 39061 529.3056 1056.5967 1056.5927 0.0040 1 14 2.3 1 R.LRAEIDNVK.K 39767 533.7638 1065.5131 1065.5090 0.0041 1 55 0.00015 1 K.YEDEINKR.T 39764 39766 39769 39770 39771 39772 39773 39774 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 40990 544.3152 1086.6158 1086.6033 0.0125 1 5 20 3 R.EQIKTLNNK.F 41336 547.2600 1092.5054 1092.5199 -0.0145 0 38 0.0077 1 K.AQYEEIANR.S 14469 14470 14471 14478 41333 41334 41338 41341 41440 547.8134 1093.6121 1093.5880 0.0242 1 42 0.0033 1 R.SLYNLGGSKR.I 14565 41425 14566 41426 14567 41427 41428 4142 42392 556.2954 1110.5763 1110.5669 0.0094 0 69 6.4e-006 1 R.ISISTSGGSFR.N 14969 42382 42384 42385 42386 14971 14972 423 43294 567.2917 1132.5689 1132.5546 0.0143 1 55 0.00017 1 R.KLLEGEECR.L 43273 43274 43276 43277 43278 43279 43280 43281 43774 572.3223 1142.6301 1142.6183 0.0119 0 38 0.0092 1 K.LAELEEALQK.A 15868 43771 15875 44302 576.7910 1151.5675 1151.5458 0.0217 1 45 0.0015 1 K.NKYEDEINK.R 16151 44289 44290 44291 44292 44293 44294 44295 44357 578.2733 1154.5320 1154.5277 0.0042 0 26 0.12 1 R.EYQELMNTK.L 45991 597.8007 1193.5868 1193.5676 0.0192 0 76 1.3e-006 1 K.YEELQQTAGR.H 45970 45971 45972 45973 45974 45976 45977 4597 17330 602.3237 1202.6328 1202.6295 0.0033 0 21 1.7 1 K.WTLLQEQGTK.T 17323 48651 627.8051 1253.5956 1253.6113 -0.0156 1 10 5.1 2 R.QSSVSFRSGGSR.S 48649 48652 48653 48655 48657 48660 48661 48 18717 641.8233 1281.6321 1281.6275 0.0046 0 34 0.017 1 R.TTAENEFVMLK.K 49914 50612 649.8194 1297.6242 1297.6224 0.0018 0 (31) 0.04 1 R.TTAENEFVM LK.K 51806 665.3746 1328.7346 1328.7187 0.0159 0 81 4.3e-007 1 R.NLDLDSIIAEVK.A 51800 51801 51802 51803 51805 51807 51808 51 53365 458.8887 1373.6442 1373.6357 0.0085 1 12 2.9 1 R.NTKHEISEMNR.M 53529 461.2661 1380.7764 1380.7110 0.0654 1 0 41 4 R.ISISTSGGSFRNR.F 54245 705.8403 1409.6660 1409.6722 -0.0061 0 81 3e-007 1 R.VSLAGACGVGGYGSR.S 54242 54244 54246 54247 54248 54249 5425 54285 705.8699 1409.7253 1409.7151 0.0102 0 64 1.8e-005 1 R.SFSTASAITPSVSR.T 54277 10132 476.2500 1425.7282 1425.7173 0.0108 1 19 2.6 1 R.TTAENEFVMLKK.D 19800

8. P04259|K2C6B_HUMAN Mass: 60315 Score: 3203 Queries matched: 313 emPAI: 3.21 Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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22129 414.2147 826.4148 826.4185 -0.0037 0 0 46 1 R.SEIDHVK.K 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.V 30598 30601 30603 30604 30605 30606 30607 30609 3 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 K.YEDEINK.R 30827 30828 30831 30834 8520 30836 30837 30839 30 33036 473.2575 944.5005 944.5039 -0.0034 1 33 0.038 1 R.GRLDSELR.N 9851 33035 33038 33039 33040 33048 33049 33053 3 33486 478.2687 954.5229 954.5134 0.0095 1 22 0.28 1 R.SEIDHVKK.Q 34195 483.2557 964.4969 964.4839 0.0131 1 39 0.0067 1 R.RGFSANSAR.L 34181 10538 34191 34192 34194 34197 34453 486.7609 971.5072 971.5036 0.0036 0 27 0.14 1 K.QEIAEINR.M 36042 501.7662 1001.5179 1001.5141 0.0037 1 20 0.72 2 R.AEEREQIK.T 36043 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 K.LLEGEECR.L 36289 36290 36291 36293 36294 36295 36296 36297 37219 513.7346 1025.4546 1025.4488 0.0059 0 22 0.3 1 K.DVDAAYMNK.V 37225 513.7741 1025.5337 1025.5142 0.0195 0 70 4.2e-006 1 R.SGFSSISVSR.S 37221 37222 37223 37224 37875 519.3028 1036.5910 1036.5665 0.0245 1 28 0.087 1 R.SLYGLGGSKR.I 37866 37867 37868 37870 37871 37872 37874 39767 533.7638 1065.5131 1065.5090 0.0041 1 55 0.00015 1 K.YEDEINKR.T 39764 39766 39769 39770 39771 39772 39773 39774 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 40990 544.3152 1086.6158 1086.6033 0.0125 1 5 20 3 R.EQIKTLNNK.F 42094 554.2745 1106.5344 1106.5356 -0.0012 0 63 2.8e-005 1 K.AQYEEIAQR.S 42081 42083 42085 42088 42089 42090 42091 42092 43294 567.2917 1132.5689 1132.5546 0.0143 1 55 0.00017 1 R.KLLEGEECR.L 43273 43274 43276 43277 43278 43279 43280 43281 44302 576.7910 1151.5675 1151.5458 0.0217 1 45 0.0015 1 K.NKYEDEINK.R 16151 44289 44290 44291 44292 44293 44294 44295 45408 590.3156 1178.6165 1178.5931 0.0234 0 64 1.9e-005 1 K.YEELQITAGR.H 45371 16776 45374 45375 16780 45376 16784 4537 17330 602.3237 1202.6328 1202.6295 0.0033 0 21 1.7 1 K.WTLLQEQGTK.T 17323 17826 611.8198 1221.6251 1221.6241 0.0010 0 30 0.053 1 R.TAAENEFVTLK.K 47174 51304 658.3551 1314.6956 1314.6891 0.0065 1 60 5.2e-005 1 R.NTKQEIAEINR.M 51305 51806 665.3746 1328.7346 1328.7187 0.0159 0 81 4.3e-007 1 R.NLDLDSIIAEVK.A 51800 51801 51802 51803 51805 51807 51808 51 52527 450.9146 1349.7221 1349.7191 0.0030 1 29 0.057 1 R.TAAENEFVTLKK.D 52524 52738 679.3691 1356.7236 1356.7249 -0.0013 1 35 0.017 1 K.NKLEGLEDALQK.A 54154 704.3618 1406.7090 1406.7041 0.0048 0 79 5.4e-007 1 K.ADTLTDEINFLR.A 54153 54524 712.8232 1423.6319 1423.6263 0.0056 0 45 0.0014 1 R.GSGGLGGACGGAGFGSR.S 54523 54525 19751 54768 718.3730 1434.7314 1434.7315 -0.0001 0 58 7.7e-005 1 R.ATGGGLSSVGGGSSTIK.Y 10917 488.1874 1461.5404 1461.7133 -0.1729 1 1 1.7e+002 2 R.NMQDLVEDLKNK.Y 56451 799.8929 1597.7712 1597.7519 0.0193 0 97 7.3e-009 1 R.ISIGGGSCAISGGYGSR.A 56449 56450 56452 56855 556.5967 1666.7682 1666.7594 0.0087 1 43 0.0018 1 R.SRGSGGLGGACGGAGFGSR.S

9. P02768|ALBU_HUMAN Mass: 71317 Score: 3015 Queries matched: 274 emPAI: 5.54 Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 27969 438.2599 874.5053 874.5025 0.0028 1 18 0.99 1 R.LSQRFPK.A 27959 27962 27965 27970 27973 27984 27985 27986 28145 440.7294 879.4443 879.4338 0.0105 0 50 0.00055 1 K.AEFAEVSK.L 28127 28128 28129 28130 28131 28132 28133 28134 31858 464.2536 926.4927 926.4861 0.0066 0 37 0.01 1 K.YLYEIAR.R 9146 9151 31855 31857 31861 31862 31863 31864 318 32399 467.2649 932.5152 932.5113 0.0039 0 31 0.052 1 K.LCTVATLR.E 32390 32392 32395 32397 32401 32403 32580 470.7295 939.4444 939.4410 0.0034 0 34 0.022 1 K.DDNPNLPR.L 32581 32582 32583 32584 32585 32604 33151 474.2712 946.5279 946.5270 0.0009 1 17 1.3 1 R.LKCASLQK.F 33879 480.7865 959.5585 959.5552 0.0033 0 48 0.00099 1 K.FQNALLVR.Y 33864 33871 33872 33874 33875 33876 33877 33878 34966 492.7475 983.4804 983.4811 -0.0007 0 49 0.00067 1 K.TYETTLEK.C 34958 34959 11211 34960 34967 34968 34970 11213 35905 500.8068 999.5990 999.5964 0.0026 0 64 2.4e-005 1 K.QTALVELVK.H 11646 11647 11648 11649 36081 501.7874 1001.5601 1001.5506 0.0096 1 32 0.036 1 K.TPVSDRVTK.C 36056 36067 36068 36092 36547 507.3038 1012.5930 1012.5917 0.0014 0 24 0.21 1 K.LVAASQAALGL.- 36550 12165 36551 36762 509.2738 1016.5330 1016.5291 0.0039 0 24 0.22 1 K.SLHTLFGDK.L 36759 12222 36789 38943 528.3026 1054.5907 1054.5811 0.0096 1 23 0.24 1 K.KYLYEIAR.R 40165 537.7794 1073.5443 1073.5353 0.0090 1 58 0.0001 1 K.LDELRDEGK.A 40137 40138 40141 40147 40149 40154 40155 40157 40269 538.2568 1074.4989 1074.4917 0.0073 0 17 1.2 1 R.NECFLQHK.D 40287 14111 542.3048 1082.5950 1082.5872 0.0078 1 4 43 7 K.YLYEIARR.H 43126 564.8570 1127.6994 1127.6914 0.0080 1 54 0.0002 1 K.KQTALVELVK.H 15569 43125 43127 43128 43664 569.7529 1137.4913 1137.4907 0.0006 0 51 0.00035 1 K.CCTESLVNR.R 43751 571.3498 1140.6851 1140.6866 -0.0015 1 36 0.013 1 K.KLVAASQAALGL.- 43747 43752 44082 575.3012 1148.5878 1148.5686 0.0192 1 28 0.082 1 R.DAHKSEVAHR.F 44088 575.3099 1148.6052 1148.6077 -0.0025 0 40 0.0052 1 K.LVNEVTEFAK.T 16046 16047 16048 16049 16051 16052 16053 1605 46210 599.3520 1196.6894 1196.5495 0.1399 1 1 34 1 K.DVCKNYAEAK.D 47465 613.8129 1225.6112 1225.5979 0.0134 1 50 0.00052 1 R.FKDLGEENFK.A 17861 47464 47466 47467 47468 50855 653.3190 1304.6234 1304.6104 0.0130 0 52 0.00029 1 K.ECCEKPLLEK.S 52327 671.8251 1341.6356 1341.6275 0.0081 0 79 5.2e-007 1 K.AVMDDFAAFVEK.C 19348 52756 679.8196 1357.6246 1357.6224 0.0022 0 (50) 0.00043 1 K.AVM DDFAAFVEK.C 53254 686.2906 1370.5666 1370.5595 0.0071 0 76 9.3e-007 1 K.AAFTECCQAADK.A 53245 53246 53247 53248 53249 53250 53251 53 54739 717.7728 1433.5310 1433.5261 0.0049 0 67 4.7e-006 1 R.ETYGEMADCCAK.Q 54740 54863 722.3300 1442.6455 1442.6347 0.0108 0 81 3.7e-007 1 K.YICENQDSISSK.L 54850 54851 54852 54853 54854 54855 54856 54 54964 725.7672 1449.5199 1449.5210 -0.0011 0 (63) 8.4e-006 1 R.ETYGEMADCCAK.Q 11069 489.9539 1466.8398 1466.8358 0.0040 1 22 0.24 1 R.RHPDYSVVLLLR.L 55655 749.7911 1497.5676 1497.5712 -0.0035 0 98 3e-009 1 K.TCVADESAENCDK.S 55651 55652 55653 55654 55656 55657 55658 5 55666 750.3155 1498.6165 1498.6246 -0.0080 1 55 0.00011 1 K.ADDKETCFAEEGK.K 55767 756.4257 1510.8368 1510.8355 0.0013 0 41 0.0031 1 K.VPQVSTPTLVEVSR.N 55765 55766 12000 55768 55769 55771 56049 516.2742 1545.8007 1545.7894 0.0112 1 30 0.042 1 K.LKECCEKPLLEK.S 56048 56050 56051 12572 56052 56053 56054 56126 776.7968 1551.5791 1551.5905 -0.0113 0 72 1.4e-006 1 K.CCAAADPHECYAK.V 56673 547.3205 1638.9397 1638.9305 0.0092 1 49 0.0004 1 K.KVPQVSTPTLVEVSR.N 56671 14500 14501 14502 56672 14515 1451 56809 829.3810 1656.7474 1656.7453 0.0021 0 89 4.1e-008 1 K.QNCELFEQLGEYK.F 58012 637.6509 1909.9309 1909.9244 0.0065 0 29 0.036 1 R.RPCFSALEVDETYVPK.E 58372 666.3159 1995.9258 1995.9221 0.0037 1 33 0.015 1 R.NECFLQHKDDNPNLPR.L 58701 682.3795 2044.1167 2044.0881 0.0286 0 35 0.0091 1 K.VFDEFKPLVEEPQNLIK.Q 62415 647.0367 2584.1177 2584.1105 0.0072 1 4 6.2 1 K.VHTECCHGDLLECADDRADLAK.Y

10. P02538|K2C6A_HUMAN Mass: 60293 Score: 2887 Queries matched: 315 emPAI: 3.47 Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22129 414.2147 826.4148 826.4185 -0.0037 0 0 46 1 R.SEIDHVK.K 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.V 30598 30601 30603 30604 30605 30606 30607 30609 3 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 K.YEDEINK.R 30827 30828 30831 30834 8520 30836 30837 30839 30 33036 473.2575 944.5005 944.5039 -0.0034 1 33 0.038 1 R.GRLDSELR.G 9851 33035 33038 33039 33040 33048 33049 33053 3 33486 478.2687 954.5229 954.5134 0.0095 1 22 0.28 1 R.SEIDHVKK.Q

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34195 483.2557 964.4969 964.4839 0.0131 1 39 0.0067 1 R.RGFSANSAR.L 34181 10538 34191 34192 34194 34197 34453 486.7609 971.5072 971.5036 0.0036 0 27 0.14 1 K.QEIAEINR.M 36042 501.7662 1001.5179 1001.5141 0.0037 1 20 0.72 2 R.AEEREQIK.T 36043 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 K.LLEGEECR.L 36289 36290 36291 36293 36294 36295 36296 36297 36501 506.7598 1011.5051 1011.4985 0.0066 0 55 0.00016 1 R.SGFSSVSVSR.S 36496 36497 36498 36499 36500 36502 36503 3650 36686 508.7729 1015.5311 1015.5298 0.0013 0 37 0.012 1 R.QLDSIVGER.G 12205 12206 36688 36689 36693 36701 36703 36704 37219 513.7346 1025.4546 1025.4488 0.0059 0 22 0.3 1 K.DVDAAYMNK.V 37875 519.3028 1036.5910 1036.5665 0.0245 1 28 0.087 1 R.SLYGLGGSKR.I 37866 37867 37868 37870 37871 37872 37874 39767 533.7638 1065.5131 1065.5090 0.0041 1 55 0.00015 1 K.YEDEINKR.T 39764 39766 39769 39770 39771 39772 39773 39774 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 40990 544.3152 1086.6158 1086.6033 0.0125 1 5 20 3 R.EQIKTLNNK.F 42094 554.2745 1106.5344 1106.5356 -0.0012 0 63 2.8e-005 1 K.AQYEEIAQR.S 42081 42083 42085 42088 42089 42090 42091 42092 43294 567.2917 1132.5689 1132.5546 0.0143 1 55 0.00017 1 R.KLLEGEECR.L 43273 43274 43276 43277 43278 43279 43280 43281 44302 576.7910 1151.5675 1151.5458 0.0217 1 45 0.0015 1 K.NKYEDEINK.R 16151 44289 44290 44291 44292 44293 44294 44295 44817 583.2977 1164.5808 1164.5775 0.0034 0 55 0.00014 1 K.YEELQVTAGR.H 44807 44812 44814 44815 44819 44824 44837 17211 599.3449 1196.6753 1196.5383 0.1370 0 4 44 6 R.GMQDLVEDFK.N 17215 17330 602.3237 1202.6328 1202.6295 0.0033 0 21 1.7 1 K.WTLLQEQGTK.T 17323 17826 611.8198 1221.6251 1221.6241 0.0010 0 30 0.053 1 R.TAAENEFVTLK.K 47174 51304 658.3551 1314.6956 1314.6891 0.0065 1 60 5.2e-005 1 R.NTKQEIAEINR.M 51305 51806 665.3746 1328.7346 1328.7187 0.0159 0 81 4.3e-007 1 R.NLDLDSIIAEVK.A 51800 51801 51802 51803 51805 51807 51808 51 52527 450.9146 1349.7221 1349.7191 0.0030 1 29 0.057 1 R.TAAENEFVTLKK.D 52524 52738 679.3691 1356.7236 1356.7249 -0.0013 1 35 0.017 1 K.NKLEGLEDALQK.A 54154 704.3618 1406.7090 1406.7041 0.0048 0 79 5.4e-007 1 K.ADTLTDEINFLR.A 54153 54524 712.8232 1423.6319 1423.6263 0.0056 0 45 0.0014 1 R.GSGGLGGACGGAGFGSR.S 54523 54525 19751 54946 724.3950 1446.7755 1446.7678 0.0077 0 65 1.6e-005 1 R.AIGGGLSSVGGGSSTIK.Y 54944 54945 54947 56451 799.8929 1597.7712 1597.7519 0.0193 0 97 7.3e-009 1 R.ISIGGGSCAISGGYGSR.A 56449 56450 56452 56855 556.5967 1666.7682 1666.7594 0.0087 1 43 0.0018 1 R.SRGSGGLGGACGGAGFGSR.S

11. Q04695|K1C17_HUMAN Mass: 48361 Score: 2462 Queries matched: 209 emPAI: 1.83 Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 R.LAADDFR.T 20206 20207 20208 20209 20210 20211 20212 20213 2 20672 405.2299 808.4453 808.4330 0.0123 0 47 0.0011 1 R.LASYLDK.V 20569 20571 587 20584 20590 20593 594 20603 20624 22392 417.2251 832.4356 832.4290 0.0066 0 29 0.09 1 K.SEISELR.R 22393 2253 22395 22396 34627 487.7642 973.5138 973.5080 0.0058 0 18 0.93 1 R.TIEELQNK.I 34628 35421 495.2797 988.5449 988.5301 0.0148 1 22 0.39 1 K.SEISELRR.T 35351 35358 35359 35364 35365 35368 35370 35372 35576 497.2542 992.4938 992.4927 0.0011 0 9 7.2 7 K.FETEQALR.L 35583 35584 37379 515.3034 1028.5922 1028.5866 0.0057 0 38 0.0087 1 R.VLDELTLAR.A 12476 12517 12518 12520 12521 12522 12523 37756 517.7642 1033.5139 1033.4975 0.0164 0 64 2.5e-005 1 R.LSGGLGAGSCR.L 37750 37751 37752 37755 37757 37842 518.7696 1035.5246 1035.5250 -0.0004 1 9 6.5 3 K.IRDWYQR.Q 37843 39379 531.7598 1061.5050 1061.4924 0.0126 0 40 0.0061 1 K.ATMQNLNDR.L 39378 39616 532.8131 1063.6117 1063.6026 0.0091 1 63 3e-005 1 R.LASYLDKVR.A 39604 39605 39606 39607 39608 39609 39610 39611 42877 561.7955 1121.5764 1121.5717 0.0048 0 39 0.0067 1 R.LEQEIATYR.R 48184 621.7767 1241.5389 1241.5458 -0.0069 0 35 0.017 1 K.NHEEEMNALR.G 48793 629.7859 1257.5573 1257.5408 0.0165 0 (32) 0.032 1 K.NHEEEMNALR.G 48791 48792 5850 435.2728 1302.7966 1302.6489 0.1477 0 1 1.8e+002 5 R.ADLEMQIENLK.E 52391 673.3509 1344.6872 1344.6772 0.0099 0 45 0.0015 1 R.ALEEANTELEVK.I 52392 52820 681.3469 1360.6792 1360.6834 -0.0042 0 101 3.8e-009 1 R.EVATNSELVQSGK.S 52817 52818 52819 19474 52821 52822 52823 5 53451 690.3605 1378.7063 1378.7204 -0.0141 1 30 0.05 1 K.TRLEQEIATYR.R 53449 54108 702.3049 1402.5953 1402.6688 -0.0735 0 10 3.9 2 K.ASLEGNLAETENR.Y 54105 54107 54791 719.8628 1437.7110 1437.6922 0.0188 1 31 0.034 1 R.ILNEMRDQYEK.M 54789 54790 55027 727.8588 1453.7030 1453.6871 0.0159 1 (28) 0.074 1 R.ILNEMRDQYEK.M 55021 55022 55024 55026 55028 55029

12. P13646|K1C13_HUMAN Mass: 49900 Score: 1639 Queries matched: 130 emPAI: 0.66 Keratin, type I cytoskeletal 13 OS=Homo sapiens GN=KRT13 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 R.LAADDFR.L 20206 20207 20208 20209 20210 20211 20212 20213 2 27539 436.1530 870.2914 870.4195 -0.1281 0 6 7.6 1 K.QSPASPER.D 27540 27570 6233 6236 6248 6251 32368 466.7653 931.5160 931.3705 0.1455 0 5 20 7 K.NHEEEMK.E 32366 33870 480.7647 959.5148 959.4924 0.0224 0 8 9.7 9 R.SLLEGQDAK.M 36773 509.2765 1016.5385 1016.5614 -0.0229 1 6 17 2 K.TEITELRR.T 12219 38610 524.7972 1047.5799 1047.5713 0.0087 1 24 0.22 1 R.LAADDFRLK.Y 38607 38609 38611 38612 14874 552.7362 1103.4578 1103.5393 -0.0815 0 1 47 3 K.ITMQNLNDR.L 42877 561.7955 1121.5764 1121.5717 0.0048 0 39 0.0067 1 R.LEQEIATYR.S 46326 601.3203 1200.6260 1200.6098 0.0161 0 64 2e-005 1 R.QSVEADINGLR.R 17292 46318 17293 46319 46320 46321 17295 463 50733 651.3414 1300.6683 1300.6510 0.0173 0 83 2.1e-007 1 R.ALEEANADLEVK.I 50709 50710 50711 50712 50713 50714 50716 18 8257 453.2396 1356.6969 1356.7110 -0.0141 1 20 1.3 1 R.QSVEADINGLRR.V 52726 8258 52728 8259 8260 52729 52730 52731 53451 690.3605 1378.7063 1378.7204 -0.0141 1 30 0.05 1 K.TRLEQEIATYR.S 53449 54236 705.4225 1408.8303 1408.6868 0.1436 0 3 18 1 K.EVSTNTAMIQTSK.T

13. O95678|K2C75_HUMAN Mass: 59809 Score: 1417 Queries matched: 201 emPAI: 0.62 Keratin, type II cytoskeletal 75 OS=Homo sapiens GN=KRT75 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 3580 424.8217 847.6288 847.4400 0.1888 0 3 30 6 R.GLGGSGSSVK.F 29146 445.2373 888.4601 888.4916 -0.0316 1 4 25 2 R.AEIDSVKK.Q 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.V 30598 30601 30603 30604 30605 30606 30607 30609 3 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 R.YEDEINK.R 30827 30828 30831 30834 8520 30836 30837 30839 30 32941 472.2932 942.5718 942.5246 0.0472 1 4 23 1 R.GRLEAELR.N 36042 501.7662 1001.5179 1001.5141 0.0037 1 20 0.72 2 R.AEEREQIK.T 36043 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 K.LLEGEECR.L 36289 36290 36291 36293 36294 36295 36296 36297 37219 513.7346 1025.4546 1025.4488 0.0059 0 22 0.3 1 K.DVDAAYMNK.V 37908 520.3046 1038.5946 1038.5094 0.0852 0 4 22 2 R.ISSAGASFGSR.S 39767 533.7638 1065.5131 1065.5090 0.0041 1 55 0.00015 1 R.YEDEINKR.T 39764 39766 39769 39770 39771 39772 39773 39774 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 40990 544.3152 1086.6158 1086.6033 0.0125 1 5 20 3 R.EQIKTLNNK.F 43294 567.2917 1132.5689 1132.5546 0.0143 1 55 0.00017 1 R.KLLEGEECR.L 43273 43274 43276 43277 43278 43279 43280 43281

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44817 583.2977 1164.5808 1164.5775 0.0034 0 55 0.00014 1 K.YEELQVTAGR.H 44807 44812 44814 44815 44819 44824 44837 19180 660.8570 1319.6994 1319.7085 -0.0091 1 3 22 2 R.TAAENEFVALKK.D 51806 665.3746 1328.7346 1328.7187 0.0159 0 81 4.3e-007 1 R.NLDLDSIIAEVK.A 51800 51801 51802 51803 51805 51807 51808 51 52968 683.3277 1364.6408 1364.6354 0.0054 1 10 4.3 3 R.NTKQEISEMNR.M 52956 52957 52958 52959 52960 52961 52962 52

14. Q7Z3Y7|K1C28_HUMAN Mass: 51191 Score: 1390 Queries matched: 146 emPAI: 0.53 Keratin, type I cytoskeletal 28 OS=Homo sapiens GN=KRT28 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 R.LAADDFR.L 20206 20207 20208 20209 20210 20211 20212 20213 2 32368 466.7653 931.5160 931.3705 0.1455 0 5 20 7 K.NHEEEMK.A 32366 34033 481.7393 961.4641 961.4254 0.0387 0 19 0.77 1 R.GLDHDYSR.Y 38610 524.7972 1047.5799 1047.5713 0.0087 1 24 0.22 1 R.LAADDFRLK.Y 38607 38609 38611 38612 14091 541.3012 1080.5879 1080.4836 0.1043 0 1 1e+002 2 K.GFGSGSPGNSSK.D 41130 545.7668 1089.5190 1089.5237 -0.0046 0 (54) 0.00024 1 K.VTMQNLNDR.L 14358 41127 41128 14359 41129 41131 14360 41133 41959 553.7641 1105.5137 1105.5186 -0.0049 0 63 2.7e-005 1 K.VTMQNLNDR.L 41958 41960 41961 41962 41963 41964 41965 4196 42267 555.2549 1108.4953 1108.4825 0.0128 0 40 0.0049 1 K.DAEAWFNEK.S 42237 42238 42239 42241 42242 42243 42244 42245 47942 619.3088 1236.6029 1236.5775 0.0255 1 54 0.0002 1 R.KDAEAWFNEK.S 47936 47937 47938 47940 47941

15. P60709|ACTB_HUMAN Mass: 42052 Score: 1365 Queries matched: 109 emPAI: 2.03 Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18752 644.3690 643.3618 643.3653 -0.0035 0 18 2.4 1 R.LDLAGR.D 18746 20080 400.7793 799.5440 799.5280 0.0160 1 28 0.096 1 K.RGILTLK.Y 20071 20072 20073 20075 20076 20078 30496 453.2357 904.4567 904.4436 0.0131 1 28 0.099 1 K.CDVDIRK.D 31681 462.2932 922.5718 922.5600 0.0118 1 25 0.16 1 K.IIAPPERK.Y 31673 31676 31677 31678 31680 34766 488.7267 975.4389 975.4410 -0.0021 0 66 1.6e-005 1 K.AGFAGDDAPR.A 11014 34762 34763 34764 34765 34767 34768 347 11537 499.7568 997.4990 997.4790 0.0200 0 (19) 0.62 1 R.DLTDYLMK.I 11534 36558 507.7536 1013.4926 1013.4739 0.0187 0 24 0.22 1 R.DLTDYLMK.I 36557 37848 518.8400 1035.6653 1035.6440 0.0213 1 22 0.32 1 K.IKIIAPPER.K 37847 12816 43237 566.7655 1131.5165 1131.5197 -0.0032 0 62 3.3e-005 1 R.GYSFTTTAER.E 43236 43238 43239 43240 43241 43242 43243 4324 44533 581.3237 1160.6328 1160.6111 0.0218 0 58 9.7e-005 1 K.EITALAPSTMK.I 44515 44516 44518 44521 44524 44537 44541 45029 586.2867 1170.5588 1170.5638 -0.0050 0 24 0.21 1 R.HQGVMVGMGQK.D 45031 45235 589.3178 1176.6210 1176.6060 0.0150 0 (32) 0.035 1 K.EITALAPSTMK.I 45234 45239 46250 599.7789 1197.5433 1197.5150 0.0284 0 57 0.00011 1 K.DSYVGDEAQSK.R 46240 17249 46241 46242 46243 46244 46245 462 46255 599.8613 1197.7080 1197.6982 0.0098 0 16 1.3 1 R.AVFPSIVGRPR.H 10 46257 46258 46380 602.3015 1202.5884 1202.5536 0.0348 0 (16) 1.5 1 R.HQGVMVGMGQK.D 52589 677.8203 1353.6261 1353.6161 0.0100 1 69 6.1e-006 1 K.DSYVGDEAQSKR.G 52585 52586 52588 52590 52592 52594 55814 506.2547 1515.7422 1515.6954 0.0468 0 43 0.0021 1 K.QEYDESGPSIVHR.K 12072 57488 895.9609 1789.9073 1789.8846 0.0227 0 111 2.9e-010 1 K.SYELPDGQVITIGNER.F 57489 17183 599.2413 1794.7020 1794.7764 -0.0744 0 1 76 2 M.DDDIAALVVDNGSGMCK.A 58209 652.0394 1953.0965 1953.0571 0.0394 0 26 0.06 1 R.VAPEEHPVLLTEAPLNPK.A 18998 18999 19000 58210

16. Q86Y46|K2C73_HUMAN Mass: 59457 Score: 1207 Queries matched: 149 emPAI: 0.35 Keratin, type II cytoskeletal 73 OS=Homo sapiens GN=KRT73 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 9255 465.3230 928.6314 928.4767 0.1548 1 0 69 1 M.SRQFTYK.S 10370 480.2756 958.5365 958.4971 0.0394 0 1 1.3e+002 2 K.VDALDGEIK.F 35941 501.2807 1000.5468 1000.5301 0.0167 1 25 0.2 1 R.AQEREQIK.V 35913 35917 35924 35928 35931 35936 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 K.LLEGEECR.M 36289 36290 36291 36293 36294 36295 36296 36297 40138 537.7670 1073.5194 1073.5829 -0.0635 1 4 22 10 R.LDSELRSVR.E 40196 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 42110 554.2803 1106.5461 1106.5720 -0.0259 1 52 0.00038 2 R.AQYEEIARK.S 42081 42083 42085 42088 42089 42090 42091 42092 43269 566.8202 1131.6258 1131.6036 0.0222 0 42 0.0035 1 K.FQELQLAAGR.H 43294 567.2917 1132.5689 1132.5546 0.0143 1 55 0.00017 1 R.KLLEGEECR.M 43273 43274 43276 43277 43278 43279 43280 43281 19453 679.3526 1356.6906 1356.7249 -0.0343 0 26 0.33 2 R.NLDLDSIIAEVR.A 19454 19457 19458 16843 591.2555 1770.7447 1770.9013 -0.1566 1 1 1.2e+002 2 K.GLSGGFSSRSLYSLGGAR.S 17680 608.3260 1821.9562 1821.7952 0.1610 0 0 1.3e+002 4 K.GGFSGCSAVLSGGSSSSYR.A

17. P02649|APOE_HUMAN Mass: 36246 Score: 1204 Queries matched: 75 emPAI: 2.26 Apolipoprotein E OS=Homo sapiens GN=APOE PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21447 409.1998 816.3851 816.3878 -0.0027 0 21 0.6 1 R.AQAWGER.L 827 830 831 21450 21676 412.7556 823.4967 823.5028 -0.0061 1 29 0.064 1 R.LASHLRK.L 21769 24974 428.2471 854.4796 854.3262 0.1533 0 2 28 2 R.MEEMGSR.T 29078 443.7699 885.5252 885.4668 0.0584 0 5 19 1 K.ELQAAQAR.L 32149 465.7611 929.5076 929.4971 0.0106 0 34 0.023 1 R.QWAGLVEK.V 32142 33274 474.7706 947.5266 947.5188 0.0077 0 60 6.6e-005 1 R.LAVYQAGAR.E 33265 33266 33267 33268 33269 33270 33271 33272 34263 484.7764 967.5382 967.5451 -0.0069 0 48 0.00068 1 R.LGPLVEQGR.V 34264 34265 10610 34266 10612 10614 34267 34268 37688 517.2833 1032.5520 1032.5352 0.0168 0 57 0.00013 1 R.LQAEAFQAR.L 37670 37675 37676 37678 37679 37680 37682 37683 41912 552.8225 1103.6305 1103.6199 0.0106 1 30 0.061 1 K.RLAVYQAGAR.E 41909 42432 557.8051 1113.5957 1113.5778 0.0179 0 64 2.1e-005 1 K.LEEQAQQIR.L 42430 42431 46864 607.8543 1213.6940 1213.6778 0.0161 1 66 1.3e-005 1 R.LSKELQAAQAR.L 47170 611.7642 1221.5138 1221.5118 0.0020 0 67 1.1e-005 1 R.LGADMEDVCGR.L 47169 47172 51222 657.3642 1312.7138 1312.7099 0.0039 1 81 3.9e-007 1 R.AKLEEQAQQIR.L 51218 51219 51220 51221 51223 51224 51225 512 51621 662.8553 1323.6961 1323.6414 0.0547 1 2 27 5 R.ALMDETMKELK.A 55638 749.4056 1496.7966 1496.7947 0.0020 0 60 4.4e-005 1 R.AATVGSLAGQPLQER.A 55637 56564 810.9079 1619.8012 1619.7904 0.0108 0 96 1.1e-008 1 K.VQAAVGTSAAPVPSDNH.- 56560 56561 56562 56563 57239 865.9327 1729.8508 1729.8370 0.0138 0 70 4.1e-006 1 K.SELEEQLTPVAEETR.A 59322 698.3635 2092.0688 2092.0324 0.0364 1 13 1.7 1 K.AYKSELEEQLTPVAEETR.A

18. P08727|K1C19_HUMAN Mass: 44065 Score: 1132 Queries matched: 122 emPAI: 0.50 Keratin, type I cytoskeletal 19 OS=Homo sapiens GN=KRT19 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 R.LAADDFR.T 20206 20207 20208 20209 20210 20211 20212 20213 2 20672 405.2299 808.4453 808.4330 0.0123 0 47 0.0011 1 R.LASYLDK.V 20569 20571 587 20584 20590 20593 594 20603 20624

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35576 497.2542 992.4938 992.4927 0.0011 0 9 7.2 7 K.FETEQALR.M 35583 35584 37379 515.3034 1028.5922 1028.5866 0.0057 0 38 0.0087 1 R.VLDELTLAR.T 12476 12517 12518 12520 12521 12522 12523 39616 532.8131 1063.6117 1063.6026 0.0091 1 63 3e-005 1 R.LASYLDKVR.A 39604 39605 39606 39607 39608 39609 39610 39611 39973 537.2853 1072.5561 1072.5876 -0.0316 0 6 17 4 K.ILGATIENSR.I 14874 552.7362 1103.4578 1103.5393 -0.0815 0 1 47 3 K.LTMQNLNDR.L 42877 561.7955 1121.5764 1121.5717 0.0048 0 39 0.0067 1 R.LEQEIATYR.S 46733 605.8007 1209.5868 1209.5778 0.0090 1 4 18 6 R.KDAEAWFTSR.T 51307 658.7688 1315.5231 1315.7095 -0.1865 1 7 8 4 R.DKILGATIENSR.I 57765 913.9114 1825.8082 1825.9336 -0.1255 1 1 23 6 R.FGPGVAFRAPSIHGGSGGR.G 60661 471.5994 2352.9607 2353.1087 -0.1480 1 1 9.5 1 K.QGPGPSRDYSHYYTTIQDLR.D

19. Q7Z3Y8|K1C27_HUMAN Mass: 50420 Score: 1095 Queries matched: 122 emPAI: 0.54 Keratin, type I cytoskeletal 27 OS=Homo sapiens GN=KRT27 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 32368 466.7653 931.5160 931.3705 0.1455 0 5 20 7 K.NHEEEMK.A 32366 34033 481.7393 961.4641 961.4254 0.0387 0 19 0.77 1 R.GLDHDYSR.Y 39632 532.8196 1063.6247 1063.5662 0.0585 0 47 0.00099 2 R.LASYLENVR.A 39604 39605 39606 39607 39608 39609 39610 39611 41130 545.7668 1089.5190 1089.5237 -0.0046 0 (54) 0.00024 1 K.VTMQNLNDR.L 14358 41127 41128 14359 41129 41131 14360 41133 41959 553.7641 1105.5137 1105.5186 -0.0049 0 63 2.7e-005 1 K.VTMQNLNDR.L 41958 41960 41961 41962 41963 41964 41965 4196 42267 555.2549 1108.4953 1108.4825 0.0128 0 40 0.0049 1 R.DAEAWFNEK.S 42237 42238 42239 42241 42242 42243 42244 42245 18542 633.3020 1264.5894 1264.5836 0.0058 1 6 43 1 R.RDAEAWFNEK.S 51818 665.8418 1329.6691 1329.6412 0.0279 0 73 2.5e-006 1 R.ALEEANADLEQK.I

20. P61626|LYSC_HUMAN Mass: 16982 Score: 1034 Queries matched: 57 emPAI: 6.81 Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20795 406.1958 810.3770 810.3694 0.0076 0 (42) 0.0029 1 R.LGMDGYR.G 20790 20791 20792 648 20794 20797 22125 414.1914 826.3683 826.3643 0.0040 0 47 0.00092 1 R.LGMDGYR.G 22120 22121 22122 22123 1696 22124 22127 30835 455.7135 909.4125 909.4015 0.0110 0 32 0.029 1 R.QYVQGCGV.- 30830 30832 32734 471.6942 941.3739 941.3701 0.0037 0 13 2.3 1 R.YWCNDGK.T 32733 32735 34226 484.2456 966.4766 966.4705 0.0061 1 24 0.19 1 K.RLGMDGYR.G 10560 34856 491.2258 980.4371 980.4312 0.0060 0 45 0.0017 1 R.ATNYNAGDR.S 34853 34854 34855 34857 34858 34943 492.2405 982.4663 982.4654 0.0009 1 (21) 0.38 1 K.RLGM DGYR.G 37910 520.3056 1038.5966 1038.5934 0.0032 1 27 0.12 1 R.VVRDPQGIR.A 37903 12886 37907 37912 12894 52905 682.3489 1362.6832 1362.6788 0.0044 0 (40) 0.0049 1 R.GISLANWMCLAK.W 53450 690.3466 1378.6786 1378.6737 0.0049 0 45 0.0014 1 R.GISLANWM CLAK.W 54076 700.8527 1399.6908 1399.6732 0.0176 0 93 2.5e-008 1 R.STDYGIFQINSR.Y 54063 54064 54065 54066 54067 54068 54069 54 65688 976.4548 2926.3425 2926.3735 -0.0311 0 50 0.00015 1 K.TPGAVNACHLSCSALLQDNIADAVACAK.R

21. Q01546|K22O_HUMAN Mass: 66400 Score: 1021 Queries matched: 174 emPAI: 0.55 Keratin, type II cytoskeletal 2 oral OS=Homo sapiens GN=KRT76 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 221 24353 425.2015 848.3884 848.4352 -0.0468 0 2 36 1 R.SAVVSGSSR.M 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.V 30598 30601 30603 30604 30605 30606 30607 30609 30 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 K.YEDEINK.R 30827 30828 30831 30834 8520 30836 30837 30839 308 35941 501.2807 1000.5468 1000.5301 0.0167 1 25 0.2 1 K.AQEREQIK.T 35913 35917 35924 35928 35931 35936 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 K.LLEGEECR.M 36289 36290 36291 36293 36294 36295 36296 36297 3 37219 513.7346 1025.4546 1025.4488 0.0058 0 12 2.7 2 K.DVDAAFMNK.V 12838 519.7622 1037.5098 1037.5029 0.0069 1 38 0.0078 1 K.KYEDEINK.R 12839 37881 39767 533.7638 1065.5131 1065.5090 0.0041 1 55 0.00015 1 K.YEDEINKR.T 39764 39766 39769 39770 39771 39772 39773 39774 3 13862 536.3226 1070.6306 1070.6084 0.0222 1 4 55 3 R.LRAEIENVK.K 13854 39895 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 40990 544.3152 1086.6158 1086.6033 0.0125 1 5 20 3 R.EQIKTLNNK.F 43294 567.2917 1132.5689 1132.5546 0.0143 1 55 0.00017 1 R.KLLEGEECR.M 43273 43274 43276 43277 43278 43279 43280 43281 15762 570.2774 1138.5403 1138.5328 0.0074 0 40 0.013 1 R.DYQELMNVK.L 15761 43681 43683 15769 44421 579.3367 1156.6588 1156.6452 0.0137 0 10 4.6 3 K.LQDLQTALQK.A 44689 582.2542 1162.4938 1162.5652 -0.0713 1 2 31 5 R.GEMALKDANAK.L 47485 614.3092 1226.6039 1226.5489 0.0550 0 4 18 10 K.SMQDLVEDFK.K

22. Q7Z3Z0|K1C25_HUMAN Mass: 49858 Score: 881 Queries matched: 90 emPAI: 0.34 Keratin, type I cytoskeletal 25 OS=Homo sapiens GN=KRT25 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 34033 481.7393 961.4641 961.4254 0.0387 0 19 0.77 1 R.GLDHDYSR.Y 41130 545.7668 1089.5190 1089.5237 -0.0046 0 (54) 0.00024 1 K.VTMQNLNDR.L 14358 41127 41128 14359 41129 41131 14360 41133 41959 553.7641 1105.5137 1105.5186 -0.0049 0 63 2.7e-005 1 K.VTMQNLNDR.L 41958 41960 41961 41962 41963 41964 41965 4196 42267 555.2549 1108.4953 1108.4825 0.0128 0 40 0.0049 1 R.DAEAWFNEK.S 42237 42238 42239 42241 42242 42243 42244 42245 42439 558.2932 1114.5719 1114.5982 -0.0263 1 7 11 1 K.KVLEEVDQR.S 18542 633.3020 1264.5894 1264.5836 0.0058 1 6 43 1 R.RDAEAWFNEK.S

23. Q7RTS7|K2C74_HUMAN Mass: 58229 Score: 827 Queries matched: 110 emPAI: 0.20 Keratin, type II cytoskeletal 74 OS=Homo sapiens GN=KRT74 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19410 676.3853 675.3780 675.3439 0.0341 0 2 47 4 K.VDSLDK.E 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 221 35941 501.2807 1000.5468 1000.5301 0.0167 1 25 0.2 1 R.AQEREQIK.V 35913 35917 35924 35928 35931 35936 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 K.LLEGEECR.M 36289 36290 36291 36293 36294 36295 36296 36297 3 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 42872 561.7754 1121.5361 1121.5941 -0.0580 1 11 4.3 2 R.SLYSLGGNRR.I 42859 42865 43294 567.2917 1132.5689 1132.5546 0.0143 1 55 0.00017 1 R.KLLEGEECR.M 43273 43274 43276 43277 43278 43279 43280 43281 19460 679.8531 1357.6916 1357.7089 -0.0172 0 11 3.5 1 R.DLDLDSIIAEVR.M 19462

24. Q5XKE5|K2C79_HUMAN Mass: 58059 Score: 792 Queries matched: 136 emPAI: 0.55 Keratin, type II cytoskeletal 79 OS=Homo sapiens GN=KRT79 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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16201 578.3512 577.3439 577.2820 0.0620 0 4 55 2 K.TSSQR.Y 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.V 30598 30601 30603 30604 30605 30606 30607 30609 3 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 K.YEDEINK.H 30827 30828 30831 30834 8520 30836 30837 30839 30 33036 473.2575 944.5005 944.5039 -0.0034 1 33 0.038 1 R.GRLDSELR.N 9851 33035 33038 33039 33040 33048 33049 33053 3 38908 528.2573 1054.5001 1054.5156 -0.0155 1 3 28 1 K.HGDNLRDTK.N 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 40990 544.3152 1086.6158 1086.6033 0.0125 1 5 20 3 R.EQIKTLNNK.F 42228 554.8058 1107.5970 1107.5884 0.0086 1 7 9.6 4 K.TTTVKTSSQR.Y 15762 570.2774 1138.5403 1138.5328 0.0074 0 40 0.013 1 R.DYQELMNVK.L 15761 43681 43683 15769 44302 576.7910 1151.5675 1151.5458 0.0217 1 45 0.0015 1 K.NKYEDEINK.H 16151 44289 44290 44291 44292 44293 44294 44295 48185 621.8053 1241.5960 1241.7092 -0.1132 1 2 30 7 K.GGPVSAGTSILRK.T 51806 665.3746 1328.7346 1328.7187 0.0159 0 81 4.3e-007 1 R.NLDLDSIIAEVK.A 51800 51801 51802 51803 51805 51807 51808 51

25. Q7Z3Y9|K1C26_HUMAN Mass: 52620 Score: 742 Queries matched: 64 emPAI: 0.15 Keratin, type I cytoskeletal 26 OS=Homo sapiens GN=KRT26 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 34211 483.7550 965.4954 965.5043 -0.0089 1 5 16 7 M.SFRLSGGSR.R 41130 545.7668 1089.5190 1089.5237 -0.0046 0 (54) 0.00024 1 K.VTMQNLNDR.L 14358 41127 41128 14359 41129 41131 14360 41133 41959 553.7641 1105.5137 1105.5186 -0.0049 0 63 2.7e-005 1 K.VTMQNLNDR.L 41958 41960 41961 41962 41963 41964 41965 4196 57706 911.9119 1821.8092 1821.8792 -0.0700 0 6 9.2 1 R.LSGGGTGFVAGNVCVGSGAR.S 57701 57702 57704 57705 57707 57710

26. P81605|DCD_HUMAN Mass: 11391 Score: 738 Queries matched: 43 emPAI: 1.45 Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7846 450.2765 898.5385 898.5600 -0.0215 1 0 2.2e+002 3 K.AVGGLGKLGK.D 43090 564.7607 1127.5067 1127.5207 -0.0139 0 69 7.1e-006 1 K.ENAGEDPGLAR.Q 43091 43092 43093 43094 43095 43096 43097 430 44505 581.2858 1160.5570 1160.5561 0.0009 0 37 0.011 1 K.DAVEDLESVGK.G 44503 44507 44508 44509 44510 44511 16336 445 55089 730.3847 1458.7549 1458.7566 -0.0017 1 46 0.0011 1 K.LGKDAVEDLESVGK.G 55090 55091

27. Q2M2I5|K1C24_HUMAN Mass: 55567 Score: 726 Queries matched: 78 emPAI: 0.14 Keratin, type I cytoskeletal 24 OS=Homo sapiens GN=KRT24 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 R.LAADDFR.L 20206 20207 20208 20209 20210 20211 20212 20213 2 8646 457.7615 913.5085 913.3712 0.1373 0 5 18 1 R.GSGFCGSSR.F 31250 31262 31307 8663 31327 31337 31349 32368 466.7653 931.5160 931.3705 0.1455 0 5 20 7 K.NHEEEMK.N 32366 38610 524.7972 1047.5799 1047.5713 0.0087 1 24 0.22 1 R.LAADDFRLK.Y 38607 38609 38611 38612 41234 546.2921 1090.5696 1090.6135 -0.0439 1 4 23 1 R.LANYLDKVR.A 46326 601.3203 1200.6260 1200.6098 0.0161 0 64 2e-005 1 R.QSVEADINGLR.K 17292 46318 17293 46319 46320 46321 17295 463

28. P08670|VIME_HUMAN Mass: 53676 Score: 703 Queries matched: 101 emPAI: 1.39 Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18780 645.3504 644.3431 644.3493 -0.0062 0 0 1.6e+002 1 R.LDLER.K 4315 429.7255 857.4364 857.4719 -0.0355 1 7 16 9 K.ARVEVER.D 26412 435.7390 869.4634 869.4283 0.0351 0 1 37 1 R.FANYIDK.V 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.I 30598 30601 30603 30604 30605 30606 30607 30609 3 31238 457.7372 913.4598 913.4505 0.0093 0 23 0.31 1 R.SYVTTSTR.T 31239 31240 32348 466.7458 931.4770 931.4610 0.0160 0 33 0.03 1 K.LLEGEESR.I 9328 9329 32342 9330 32345 32346 37124 512.2663 1022.5181 1022.5033 0.0149 0 49 0.00065 1 R.QQYESVAAK.N 37118 37121 37122 37125 37126 37128 38423 523.7857 1045.5568 1045.5226 0.0342 0 15 2 1 K.LQEEMLQR.E 13389 529.3397 1056.6648 1056.5134 0.1513 1 4 59 2 K.EEMARHLR.E 13359 39217 530.7749 1059.5353 1059.5197 0.0157 0 43 0.0032 1 R.QVDQLTNDK.A 39215 39216 39218 39267 530.7964 1059.5782 1059.5560 0.0222 1 49 0.00082 1 R.KLLEGEESR.I 39219 39220 39221 39224 39238 39241 40353 538.7635 1075.5124 1075.4968 0.0157 0 23 0.3 1 R.DNLAEDIMR.L 41009 544.7799 1087.5453 1087.5258 0.0195 0 59 7e-005 1 R.QDVDNASLAR.L 41000 41002 41003 41005 41006 41007 41008 4101 41359 547.2809 1092.5472 1092.5200 0.0272 0 51 0.00039 1 K.FADLSEAANR.N 41347 41350 41353 41354 14489 41356 41357 4135 15260 561.3076 1120.6006 1120.5764 0.0242 0 19 2.7 1 R.EYQDLLNVK.M 15263 48647 627.7992 1253.5838 1253.5598 0.0240 0 43 0.0022 1 R.LGDLYEEEMR.E 50155 644.3446 1286.6747 1286.6579 0.0169 1 61 3.8e-005 1 R.QVDQLTNDKAR.V 50153 50157 51021 655.3285 1308.6425 1308.5986 0.0439 0 6 12 1 K.NLQEAEEWYK.S 54666 714.8694 1427.7241 1427.7045 0.0197 0 53 0.00024 1 R.SLYASSPGGVYATR.S 54667 55585 499.2749 1494.8028 1494.7790 0.0238 0 5 14 1 R.TYSLGSALRPSTSR.S 12428 513.9818 1538.9235 1538.9032 0.0203 1 21 0.25 1 K.ILLAELEQLKGQGK.S 57467 592.9671 1775.8795 1775.8550 0.0244 1 5 10 1 K.FADLSEAANRNNDALR.Q 57824 612.9483 1835.8230 1835.7922 0.0308 0 18 0.51 1 R.DGQVINETSQHHDDLE.- 57821 57822 57823

29. Q99456|K1C12_HUMAN Mass: 53592 Score: 696 Queries matched: 95 emPAI: 0.31 Keratin, type I cytoskeletal 12 OS=Homo sapiens GN=KRT12 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18360 630.3987 629.3914 629.3497 0.0418 0 9 21 1 R.TPGLSR.R 18337 20672 405.2299 808.4453 808.4330 0.0123 0 47 0.0011 1 R.LASYLDK.V 20569 20571 587 20584 20590 20593 594 20603 20624 20 12844 519.7867 1037.5589 1037.4625 0.0964 0 0 47 2 K.SQAQSTDSSK.D 13475 530.2954 1058.5762 1058.5972 -0.0209 0 43 0.0086 1 R.VLDELTLTR.T 13455 39616 532.8131 1063.6117 1063.6026 0.0091 1 63 3e-005 1 R.LASYLDKVR.A 39604 39605 39606 39607 39608 39609 39610 39611 3 44825 583.3001 1164.5857 1164.6026 -0.0169 0 32 0.033 2 R.LELEIETYR.R 44803 44804 44805 44806 44808 44809 44810 44811 4

30. P19013|K2C4_HUMAN Mass: 57649 Score: 680 Queries matched: 65 emPAI: 0.06 Keratin, type II cytoskeletal 4 OS=Homo sapiens GN=KRT4 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21443 408.7500 815.4854 815.4388 0.0465 0 8 12 4 R.AEIENIK.K 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 36230 502.3056 1002.5967 1002.4982 0.0985 0 6 14 5 K.QLDTLGNDK.G 37562 516.7744 1031.5343 1031.5247 0.0096 1 25 0.22 1 R.TEEREQIK.L 37560 37561 37563 42094 554.2745 1106.5344 1106.5356 -0.0012 0 63 2.8e-005 1 R.AQYEEIAQR.S 42081 42083 42085 42088 42089 42090 42091 42092

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49484 635.7871 1269.5597 1269.5772 -0.0175 0 1 36 1 R.GAFSSVSMSGGAGR.C 19453 679.3526 1356.6906 1356.7249 -0.0343 0 26 0.33 2 R.NLDLDSIIAEVR.A 19454 19457 19458 9530 469.3287 1404.9642 1404.7976 0.1666 1 1 54 2 K.LALDIEIATYRK.L

31. Q6S8J3|POTEE_HUMAN Mass: 122882 Score: 676 Queries matched: 87 emPAI: 0.13 POTE ankyrin domain family member E OS=Homo sapiens GN=POTEE PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15337 562.2869 561.2796 561.2758 0.0038 0 2 50 8 K.EAQSK.R 18752 644.3690 643.3618 643.3653 -0.0035 0 18 2.4 1 R.LDLAGR.E 18746 20080 400.7793 799.5440 799.5280 0.0160 1 28 0.096 1 K.RGILTLK.Y 20071 20072 20073 20075 20076 20078 34766 488.7267 975.4389 975.4410 -0.0021 0 66 1.6e-005 1 K.AGFAGDDAPR.A 11014 34762 34763 34764 34765 34767 34768 347 35240 494.3042 986.5938 986.5947 -0.0008 1 3 32 4 R.KDLIVMLR.D 36150 502.2786 1002.5426 1002.5896 -0.0470 1 (0) 57 10 R.KDLIVMLR.D 40521 539.7555 1077.4965 1077.4938 0.0027 0 2 36 3 K.LTSEEESQR.F 41637 551.2963 1100.5781 1100.5210 0.0570 1 10 4.9 1 K.GSENGQPEKR.S 42097 554.2755 1106.5365 1106.5277 0.0087 0 9 6.7 6 K.MSQELEINK.D 42081 42083 42088 42089 42090 42091 42092 42093 45675 593.8244 1185.6343 1185.5989 0.0353 1 3 24 2 R.LKGSENGQPEK.R 46255 599.8613 1197.7080 1197.6982 0.0098 0 16 1.3 1 R.AVFPSIVGRPR.Q 46240 10 46257 46258 971 411.2236 1230.6489 1230.6390 0.0098 1 1 1.2e+002 3 R.CQLNVLDNKK.R 47587 616.8051 1231.5956 1231.5260 0.0696 0 5 18 4 R.QQGMMGGMHQK.E 47573 47585 47599 55270 737.8653 1473.7161 1473.6947 0.0214 0 4 17 1 K.ISSENSNPEQELK.L 55814 506.2547 1515.7422 1515.6954 0.0468 0 43 0.0021 1 K.QEYDESGPSIVHR.K 12072 57488 895.9609 1789.9073 1789.8846 0.0227 0 111 2.9e-010 1 K.SYELPDGQVITIGNER.F 57489

32. P31025|LCN1_HUMAN Mass: 19409 Score: 564 Queries matched: 48 emPAI: 0.72 Lipocalin-1 OS=Homo sapiens GN=LCN1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 27594 436.2654 870.5162 870.5076 0.0087 0 17 1.3 1 K.HVAYIIR.S 6220 27578 27584 27585 27586 27592 27593 27598 27 6485 438.7540 875.4935 875.4899 0.0037 0 15 2.2 1 K.VTMLISGR.C 45654 593.3366 1184.6586 1184.6765 -0.0179 0 62 3.5e-005 1 R.GLSTESILIPR.Q 16954 45655 45656 45658 45659 45660 45661 16 51453 661.3186 1320.6226 1320.6197 0.0029 0 43 0.0026 1 K.NNLEALEDFEK.A 19185 19186 19187 19188 19190 19191 19192 514 52077 669.8393 1337.6640 1337.6099 0.0540 1 35 0.016 1 K.TDEPGKYTADGGK.H

33. P12035|K2C3_HUMAN Mass: 64636 Score: 540 Queries matched: 134 emPAI: 0.56 Keratin, type II cytoskeletal 3 OS=Homo sapiens GN=KRT3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19681 704.3763 703.3690 703.3752 -0.0062 0 30 0.076 1 R.LDSELK.N 20367 404.2356 806.4566 806.4068 0.0498 1 5 21 2 -.MSRQASK.T 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 221 24353 425.2015 848.3884 848.4352 -0.0468 0 2 36 1 R.SAVVSGSSR.M 27821 437.2668 872.5191 872.4967 0.0224 1 3 39 8 R.AEIEGVKK.Q 27810 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.V 30598 30601 30603 30604 30605 30606 30607 30609 30 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 K.YEDEINK.R 30827 30828 30831 30834 8520 30836 30837 30839 308 31555 459.2740 916.5334 916.4978 0.0356 1 0 68 2 R.GRLDSELK.N 10850 487.2672 972.5198 972.5240 -0.0041 0 5 70 8 K.SEIIELNR.M 35941 501.2807 1000.5468 1000.5301 0.0167 1 25 0.2 1 K.AQEREQIK.T 35913 35917 35924 35928 35931 35936 12838 519.7622 1037.5098 1037.5029 0.0069 1 38 0.0078 1 K.KYEDEINK.R 12839 37881 39767 533.7638 1065.5131 1065.5090 0.0041 1 55 0.00015 1 K.YEDEINKR.T 39764 39766 39769 39770 39771 39772 39773 39774 3 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 40990 544.3152 1086.6158 1086.6033 0.0125 1 5 20 3 R.EQIKTLNNK.F 41351 547.2718 1092.5291 1092.5200 0.0091 0 15 1.7 2 R.AQYEDIAQR.S 14470 14471 14478 41334 41336 41338 41343 41344 41470 549.2536 1096.4925 1096.4898 0.0028 0 1 40 5 K.TSGGGSQGFSGR.S 15762 570.2774 1138.5403 1138.5328 0.0074 0 40 0.013 1 R.DYQELMNVK.L 15761 43681 43683 15769 17826 611.8198 1221.6251 1221.6241 0.0010 0 30 0.053 1 R.TAAENEFVTLK.K 47174 52527 450.9146 1349.7221 1349.7191 0.0030 1 29 0.057 1 R.TAAENEFVTLKK.D 52524 66396 512.5489 3069.2500 3069.4019 -0.1519 0 5 1.8 1 R.TLYDAELSQMQSHISDTSVVLSMDNNR.S

34. P12036|NFH_HUMAN Mass: 112639 Score: 526 Queries matched: 60 emPAI: 0.10 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 30292 451.2551 900.4957 900.4665 0.0292 1 4 26 1 K.TPAKEEAR.S 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 K.LLEGEECR.I 36289 36290 36291 36293 36294 36295 36296 36297 3 37557 516.7687 1031.5229 1031.4996 0.0233 1 3 33 10 R.QRSELEDR.H 40986 544.3042 1086.5937 1086.5557 0.0381 1 5 19 1 K.EEAKSPAEVK.S 15260 561.3076 1120.6006 1120.5764 0.0242 0 19 2.7 1 R.EYQDLLNVK.M 15263 43294 567.2917 1132.5689 1132.5546 0.0143 1 55 0.00017 1 R.KLLEGEECR.I 43273 43274 43276 43277 43278 43279 43280 43281 52449 674.8346 1347.6546 1347.6816 -0.0270 1 2 37 7 R.DALKCDVTSALR.E

35. Q92764|KRT35_HUMAN Mass: 51635 Score: 428 Queries matched: 49 emPAI: 0.07 Keratin, type I cuticular Ha5 OS=Homo sapiens GN=KRT35 PE=2 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 K.LAADDFR.T 20206 20207 20208 20209 20210 20211 20212 20213 2 35251 494.7751 987.5357 987.5600 -0.0243 1 5 19 1 R.TIEELQKK.T 38610 524.7972 1047.5799 1047.6077 -0.0277 1 6 14 5 R.LAGYLEKVR.H 14478 547.2553 1092.4959 1092.4870 0.0090 0 2 1.2e+002 4 K.ETMQSLNDR.L 48197 622.3662 1242.7178 1242.6568 0.0610 0 4 16 3 R.QLVESDINGLR.R 9401 467.3052 1398.8937 1398.7579 0.1357 1 12 6.3 1 R.QLVESDINGLRR.I

36. P05783|K1C18_HUMAN Mass: 48029 Score: 428 Queries matched: 50 emPAI: 0.08 Keratin, type I cytoskeletal 18 OS=Homo sapiens GN=KRT18 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 R.LAADDFR.V 20206 20207 20208 20209 20210 20211 20212 20213 20 2458 419.3118 836.6091 836.4392 0.1699 0 0 1.2e+002 4 R.LASYLDR.V 38501 523.8044 1045.5942 1045.5404 0.0538 0 0 56 1 K.VIDDTNITR.L 14445 546.8143 1091.6141 1091.6087 0.0054 1 12 3.4 1 R.LASYLDRVR.S 14478 547.2553 1092.4959 1092.4870 0.0090 0 2 1.2e+002 4 K.ETMQSLNDR.L

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2443 419.2321 1254.6745 1254.6278 0.0467 1 2 1.2e+002 8 R.VKYETELAMR.Q 48689

37. O76013|KRT36_HUMAN Mass: 53354 Score: 428 Queries matched: 48 emPAI: 0.07 Keratin, type I cuticular Ha6 OS=Homo sapiens GN=KRT36 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20224 404.2094 806.4042 806.3923 0.0119 0 60 6.6e-005 1 K.LAADDFR.T 20206 20207 20208 20209 20210 20211 20212 20213 2 4609 431.3183 860.6221 860.4716 0.1505 1 1 1.5e+002 1 R.DGKVISSR.E 46361 601.7904 1201.5662 1201.6190 -0.0528 0 4 20 10 K.ADLEAQVESLK.E 59090 414.0397 2065.1620 2065.0375 0.1245 1 3 11 4 R.SVGSCRVPSLAGAAGYISSAR.S 59064

38. P36222|CH3L1_HUMAN Mass: 42998 Score: 428 Queries matched: 51 emPAI: 1.12 Chitinase-3-like protein 1 OS=Homo sapiens GN=CHI3L1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 782 408.2336 814.4526 814.4701 -0.0176 0 16 4.2 4 K.SVPPFLR.T 21345 791 21371 21389 802 24956 428.2460 854.4774 854.4722 0.0052 1 2 28 5 K.NRNPNLK.T 25814 433.2587 864.5028 864.5069 -0.0041 1 12 3.2 1 K.SKVQYLK.D 25832 25838 30446 452.2752 902.5359 902.5225 0.0134 0 19 0.9 1 R.FPLTNAIK.D 30408 30422 30443 31617 461.2597 920.5048 920.5080 -0.0031 1 30 0.065 1 K.VQYLKDR.Q 31622 8931 31624 12070 506.2448 1010.4749 1010.5106 -0.0357 1 1 1.4e+002 7 K.EMKAEFIK.E 41172 545.8127 1089.6109 1089.6005 0.0104 0 (14) 2.4 1 K.LVMGIPTFGR.S 41175 41205 42013 553.8159 1105.6173 1105.5954 0.0219 0 16 1.4 1 K.LVMGIPTFGR.S 42012 45038 586.3393 1170.6641 1170.6972 -0.0331 0 16 1.4 1 K.QLLLSAALSAGK.V 46672 403.8787 1208.6142 1208.6051 0.0091 0 29 0.062 1 R.GTTGHHSPLFR.G 46669 46671 46674 46675 46676 46677 46678 46750 606.3196 1210.6246 1210.6081 0.0165 0 56 0.00012 1 K.VTIDSSYDIAK.I 17612 46747 46748 46749 46972 609.3522 1216.6898 1216.6816 0.0082 0 60 5.3e-005 1 R.ILGQQVPYATK.G 46964 46968 46969 46970 46971 46973 46975 47545 410.9095 1229.7066 1229.6768 0.0298 1 19 0.7 1 R.DKQHFTTLIK.E 54784 719.8134 1437.6122 1437.5831 0.0291 0 91 2.9e-008 1 R.EGDGSCFPDALDR.F 54782 54783 56580 812.8786 1623.7426 1623.7165 0.0261 0 59 4.7e-005 1 K.GNQWVGYDDQESVK.S

39. P08729|K2C7_HUMAN Mass: 51430 Score: 422 Queries matched: 145 emPAI: 0.32 Keratin, type II cytoskeletal 7 OS=Homo sapiens GN=KRT7 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.L 30598 30601 30603 30604 30605 30606 30607 30609 3 32348 466.7458 931.4770 931.4610 0.0160 0 33 0.03 1 K.LLEGEESR.L 9328 9329 32342 9330 32345 32346 35789 500.2247 998.4349 998.4379 -0.0030 0 25 0.17 3 K.DVDAAYMSK.V 35787 35790 35792 35793 35794 35795 35796 35798 36579 508.2274 1014.4403 1014.4328 0.0075 0 (9) 8.6 4 K.DVDAAYMSK.V 36573 12179 36574 36575 36576 36577 36578 36580 39267 530.7964 1059.5782 1059.5560 0.0222 1 49 0.00082 1 R.KLLEGEESR.L 39219 39220 39221 39224 39238 39241 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 43055 564.2839 1126.5533 1126.5328 0.0204 1 24 0.2 2 K.KDVDAAYMSK.V 43043 43045 43046 43049 43050 43758 572.2782 1142.5418 1142.5278 0.0141 1 (24) 0.24 3 K.KDVDAAYMSK.V 43753 43756 43759 43760 43761 43762 43765 201 401.2143 1200.6212 1200.5986 0.0226 0 3 1.3e+002 1 K.LEAAIAEAEER.G 46842 607.2555 1212.4965 1212.5333 -0.0368 0 4 15 1 R.SMQDVVEDFK.N 47053 610.7846 1219.5547 1219.6448 -0.0901 0 2 37 1 R.TAAENEFVVLK.K 9530 469.3287 1404.9642 1404.7976 0.1666 1 1 54 2 K.LALDIEIATYRK.L

40. Q86YZ3|HORN_HUMAN Mass: 283140 Score: 407 Queries matched: 35 emPAI: 0.11 Hornerin OS=Homo sapiens GN=HRNR PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10476 482.3027 962.5908 962.4530 0.1379 1 9 17 1 R.SGQSSRGER.H 42982 563.2694 1124.5241 1124.5210 0.0031 1 59 5.6e-005 1 R.SSSRGPYESR.S 42981 42986 42994 42996 42997 43005 43680 570.2653 1138.5161 1138.5003 0.0157 0 73 2.1e-006 1 R.GSGSGQSPSYGR.H 43679 966 411.2224 1230.6454 1230.6568 -0.0114 0 3 70 1 R.GSLKPGTESISR.R 923 975 53932 698.3224 1394.6302 1394.6175 0.0128 0 36 0.012 1 R.YGQQGSGSGQSPSR.G 53929 13039 521.3154 1560.9244 1560.7254 0.1990 1 2 1e+002 1 R.GRHGSGSGQSPGHGQR.G 56344 792.8577 1583.7008 1583.7077 -0.0069 0 73 1.8e-006 1 R.GPYESGSGHSSGLGHR.E 56343 56345 56346 56347 56348 56349 563 57322 583.2730 1746.7971 1746.7670 0.0300 0 18 0.58 1 R.GSGSGQSPSSGQHGTGFGR.S 57404 883.3777 1764.7408 1764.8000 -0.0592 1 2 18 3 R.QSSGHGRQGSGSGHSPSR.G 57652 603.5981 1807.7725 1807.7470 0.0255 0 51 0.00028 1 R.HGSSSGSSSSYGQHGSGSR.Q 57876 465.4503 1857.7722 1857.7739 -0.0017 0 3 13 1 R.HGSSSGSSSHYGQHGSGSR.Q 58176 649.9750 1946.9032 1946.8943 0.0088 0 47 0.00065 1 R.QSLGHGQHGSGSGQSPSPSR.G 58175 58177 58178 59443 708.3004 2121.8793 2121.8696 0.0097 0 37 0.0035 1 R.GEQHGSSSGSSSSYGQHGSGSR.Q

41. P02787|TRFE_HUMAN Mass: 79280 Score: 402 Queries matched: 36 emPAI: 0.65 Serotransferrin OS=Homo sapiens GN=TF PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18309 629.2378 628.2306 628.3656 -0.1351 0 6 23 1 K.AVGNLR.K 18305 34165 482.7751 963.5357 963.5250 0.0107 0 87 1.2e-007 1 R.APNHAVVTR.K 34162 34163 34164 34166 35881 500.7530 999.4915 999.4913 0.0002 0 12 3.4 1 K.YLGEEYVK.A 41293 546.8164 1091.6182 1091.6200 -0.0017 1 34 0.023 1 R.APNHAVVTRK.D 43013 563.2787 1124.5429 1124.6124 -0.0695 1 12 3.2 6 K.EACVHKILR.Q 42984 42985 42988 42993 43001 43004 43006 4300 44926 583.7947 1165.5748 1165.5840 -0.0092 0 43 0.0022 1 K.HQTVPQNTGGK.N 44923 46088 598.2818 1194.5490 1194.5452 0.0039 0 50 0.00043 1 K.DSGFQMNQLR.G 46746 606.2863 1210.5580 1210.5401 0.0180 0 (25) 0.15 1 K.DSGFQM NQLR.G 49533 637.3289 1272.6433 1272.6462 -0.0029 0 36 0.013 1 K.HSTIFENLANK.A 49976 642.2906 1282.5666 1282.5618 0.0047 0 34 0.019 1 K.EGYYGYTGAFR.C 51603 441.9019 1322.6840 1322.6401 0.0439 1 (4) 17 3 K.KDSGFQMNQLR.G 51591 51596 51602 52137 670.3083 1338.6020 1338.6350 -0.0330 1 4 17 5 K.KDSGFQMNQLR.G 53410 459.9062 1376.6967 1376.6936 0.0031 1 2 28 2 K.KSASDLTWDNLK.G 54375 708.3598 1414.7050 1414.7126 -0.0077 0 45 0.0014 1 K.SVIPSDGPSVACVK.K 56305 789.3331 1576.6517 1576.6504 0.0013 0 52 0.00022 1 R.FDEFFSEGCAPGSK.K 56370 529.6012 1585.7818 1585.7671 0.0147 0 59 5e-005 1 R.KPVEEYANCHLAR.A 57210 863.3834 1724.7523 1724.7597 -0.0074 0 58 4.8e-005 1 K.IECVSAETTEDCIAK.I 57679 606.6135 1816.8186 1816.7972 0.0214 0 10 3.3 1 R.EGTCPEAPTDECKPVK.W

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42. P04075|ALDOA_HUMAN Mass: 39851 Score: 374 Queries matched: 31 emPAI: 1.05 Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20116 401.2499 800.4852 800.4756 0.0096 0 38 0.011 1 R.ALQASALK.A 20108 20109 219 20110 20111 20117 32504 469.2408 936.4671 936.4552 0.0119 0 36 0.014 1 K.AAQEEYVK.R 32506 9531 32588 470.7457 939.4767 939.4774 -0.0006 0 53 0.00028 1 K.ELSDIAHR.I 32586 32587 32591 32592 34426 486.3049 970.5953 970.5811 0.0141 1 36 0.014 1 K.GGVVGIKVDK.G 34424 39641 533.2468 1064.4791 1064.5039 -0.0248 1 1 42 9 K.DGADFAKWR.C 39830 534.8053 1067.5961 1067.5723 0.0238 1 16 1.3 1 K.KELSDIAHR.I 41360 547.2850 1092.5555 1092.5563 -0.0008 1 51 0.0004 1 K.AAQEEYVKR.A 41363 43251 566.7970 1131.5794 1131.5706 0.0088 0 58 8.5e-005 1 R.ALANSLACQGK.Y 43247 43248 51860 666.8543 1331.6941 1331.6932 0.0009 0 79 6.6e-007 1 K.GILAADESTGSIAK.R 51859 51861 51862 52328 671.8648 1341.7150 1341.7041 0.0109 0 29 0.06 1 K.ADDGRPFPQVIK.S 56723 549.6151 1645.8236 1645.8019 0.0217 1 14 1.5 1 R.LQSIGTENTEENRR.F 56722

43. Q3SY84|K2C71_HUMAN Mass: 57727 Score: 339 Queries matched: 71 emPAI: 0.13 Keratin, type II cytoskeletal 71 OS=Homo sapiens GN=KRT71 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 221 33317 476.2363 950.4580 950.5185 -0.0605 0 4 22 4 R.SLYSLGGVR.S 33318 10127 33328 10403 481.2290 960.4435 960.5240 -0.0805 1 1 89 3 K.GSSLSAPSKK.T 35686 498.2922 994.5698 994.4971 0.0727 1 6 11 1 R.DVVEDYKK.R 35941 501.2807 1000.5468 1000.5301 0.0167 1 25 0.2 1 R.AQEREQIK.A 35913 35917 35924 35928 35931 35936 40125 537.3250 1072.6355 1072.4794 0.1561 1 6 15 1 -.MSRQFTCK.S 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 41591 551.2810 1100.5475 1100.5938 -0.0463 1 10 5.2 1 R.LDSELRNVR.D 41581 41582 41592 41594 41598 41600 41609 14770 43269 566.8202 1131.6258 1131.6036 0.0222 0 42 0.0035 1 K.FQELQLAAGR.H 44689 582.2542 1162.4938 1162.5652 -0.0713 1 1 45 9 R.KLLESEECR.M 50833 652.8503 1303.6860 1303.6732 0.0128 1 7 8.9 2 K.NTKNEISELTR.L

44. P60174|TPIS_HUMAN Mass: 26938 Score: 336 Queries matched: 15 emPAI: 1.51 Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24401 425.7349 849.4552 849.4596 -0.0044 0 28 0.097 1 K.VVFEQTK.V 24402 43575 569.3029 1136.5911 1136.5648 0.0263 0 52 0.00035 1 K.IAVAAQNCYK.V 15714 47720 617.7960 1233.5775 1233.5949 -0.0174 0 85 1.5e-007 1 K.SNVSDAVAQSTR.I 47721 47722 47753 48893 630.8259 1259.6372 1259.6357 0.0015 1 31 0.045 1 K.LDEREAGITEK.V 48834 48846 49544 637.8371 1273.6597 1273.6666 -0.0069 1 47 0.001 1 K.VIADNVKDWSK.V 51687 663.8411 1325.6677 1325.6649 0.0028 0 90 4.6e-008 1 R.IIYGGSVTGATCK.E 51686 55169 733.8581 1465.7017 1465.7161 -0.0144 0 26 0.093 1 K.TATPQQAQEVHEK.L

45. Q14CN4|K2C72_HUMAN Mass: 56470 Score: 330 Queries matched: 89 emPAI: 0.14 Keratin, type II cytoskeletal 72 OS=Homo sapiens GN=KRT72 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 221 35941 501.2807 1000.5468 1000.5301 0.0167 1 25 0.2 1 R.AQEREQIK.A 35913 35917 35924 35928 35931 35936 36646 508.2835 1014.5525 1014.5934 -0.0409 1 1 51 10 R.SLALSAAARR.G 37219 513.7346 1025.4546 1025.4488 0.0059 0 22 0.3 1 K.DVDAAYMNK.V 40767 541.8107 1081.6068 1081.5920 0.0148 1 53 0.00026 1 K.FASFIDKVR.F 40736 40744 40750 40751 40752 40753 40754 40755 44308 577.2737 1152.5329 1152.5662 -0.0334 0 14 2 1 K.AEAETLYQTK.I 44306 44307 44309 44312 44313 44314 44315 4431 44689 582.2542 1162.4938 1162.5652 -0.0713 1 1 45 9 R.KLLESEECR.M 47053 610.7846 1219.5547 1219.6448 -0.0901 0 2 37 1 R.TAAENEFVVLK.K 19460 679.8531 1357.6916 1357.7089 -0.0172 0 11 3.5 1 R.DLDLDSIIAEVR.A 19462 53150 684.8444 1367.6743 1367.6932 -0.0189 1 20 0.41 1 K.SKAEAETLYQTK.I 53120 53123 53124 53127 53130 53134 53135 531

46. Q7Z794|K2C1B_HUMAN Mass: 61935 Score: 322 Queries matched: 64 emPAI: 0.42 Keratin, type II cytoskeletal 1b OS=Homo sapiens GN=KRT77 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22145 414.2243 826.4341 826.4225 0.0116 0 28 0.082 1 K.FASFIDK.V 1701 22131 22133 22134 22137 22138 22140 22141 22 30840 455.7202 909.4258 909.4079 0.0178 0 28 0.091 1 K.YEDEINK.R 30827 30828 30831 30834 8520 30836 30837 30839 30 34227 484.2457 966.4768 966.4658 0.0110 0 30 0.053 1 K.DVDAAYVSK.V 34224 34228 35824 500.2656 998.5167 998.5872 -0.0706 1 1 44 3 K.EELARLLR.D 39267 530.7964 1059.5782 1059.5196 0.0586 0 49 0.00082 1 R.QLLEGEESR.M 39219 39220 39221 39224 39238 39241 39767 533.7638 1065.5131 1065.5090 0.0041 1 55 0.00015 1 K.YEDEINKR.T 39764 39766 39769 39770 39771 39772 39773 39774 41847 552.7856 1103.5566 1103.5645 -0.0078 0 1 46 7 R.EQIMVLNNK.F 42755 561.3071 1120.5996 1120.5876 0.0119 0 25 0.19 2 R.TQYELIAQR.S 42750 42756 43141 565.3174 1128.6203 1128.6502 -0.0299 1 10 5.2 2 R.LQAEISNVKK.Q 45306 589.8236 1177.6327 1177.6091 0.0236 0 28 0.089 1 K.YQELQITAGR.H 50200 645.3350 1288.6555 1288.6445 0.0110 0 10 5.4 1 R.QVDLLSAEQMR.Q 50855 653.3190 1304.6234 1304.6394 -0.0160 0 (9) 5.4 3 R.QVDLLSAEQMR.Q 53582 691.8547 1381.6948 1381.6725 0.0223 1 80 4.1e-007 1 R.SKDEAEALYQTK.Y

47. P14780|MMP9_HUMAN Mass: 79492 Score: 290 Queries matched: 16 emPAI: 0.44 Matrix metalloproteinase-9 OS=Homo sapiens GN=MMP9 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11946 504.2792 503.2719 503.2816 -0.0097 1 0 1.1e+002 1 R.SGRGK.M 21440 408.7103 815.4061 815.3960 0.0101 0 23 0.41 1 K.AQMVDPR.S 33761 480.2108 958.4070 958.3967 0.0103 0 33 0.032 1 K.AYFCQDR.F 34791 489.2604 976.5061 976.4978 0.0084 0 23 0.34 1 R.AVIDDAFAR.A 11034 40889 542.7740 1083.5334 1083.5237 0.0097 0 34 0.019 1 R.FQTFEGDLK.W 42458 559.2366 1116.4587 1116.4506 0.0081 0 30 0.056 1 R.SYSACTTDGR.S 42894 561.8499 1121.6853 1121.5717 0.1136 1 5 16 8 R.KLDSVFEER.L 44305 576.8745 1151.7344 1151.7278 0.0066 0 57 8.1e-005 1 K.SLGPALLLLQK.Q 44304 45718 595.2444 1188.4742 1188.4717 0.0025 0 38 0.0086 1 K.EYSTCTSEGR.G 18192 623.2611 1244.5076 1244.5972 -0.0895 1 0 1.1e+002 8 R.YGYTRVAEMR.G 52393 673.3794 1344.7442 1344.7402 0.0040 0 47 0.00089 1 R.QSTLVLFPGDLR.T 7700

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54808 720.9140 1439.8135 1439.8096 0.0039 0 102 2.4e-009 1 K.LGLGADVAQVTGALR.S 57051 851.4504 1700.8863 1700.8832 0.0031 0 88 5.7e-008 1 K.QLSLPETGELDSATLK.A

48. P63104|1433Z_HUMAN Mass: 27899 Score: 275 Queries matched: 15 emPAI: 1.15 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 30673 454.2644 906.5143 906.5174 -0.0031 0 33 0.033 1 R.NLLSVAYK.N 30674 30676 30679 10816 487.1846 972.3546 972.5240 -0.1694 1 6 53 4 M.DKNELVQK.A 42225 554.7760 1107.5374 1107.5495 -0.0121 0 19 0.61 1 K.EMQPTHPIR.L 49782 640.3248 1278.6351 1278.6456 -0.0105 1 51 0.00036 1 R.YLAEVAAGDDKK.G 49781 49783 49785 50832 652.8449 1303.6752 1303.6772 -0.0020 0 43 0.0023 1 K.FLIPNASQAESK.V 55720 752.8890 1503.7634 1503.7780 -0.0146 1 71 3.3e-006 1 R.VVSSIEQKTEGAEK.K 55721 56072 774.8565 1547.6985 1547.7063 -0.0078 0 95 1.5e-008 1 K.SVTEQGAELSNEER.N 56073

49. P06396|GELS_HUMAN Mass: 86043 Score: 272 Queries matched: 30 emPAI: 0.40 Gelsolin OS=Homo sapiens GN=GSN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13494 530.3097 529.3024 529.3224 -0.0200 0 9 26 1 R.VVQGK.E 17773 610.3182 609.3109 609.3347 -0.0238 0 5 36 1 R.AVQHR.E 19390 675.3531 674.3458 674.2983 0.0475 0 3 78 1 K.EDAANR.K 22545 420.2247 838.4348 838.3756 0.0593 0 0 46 2 K.MDAHPPR.L 24289 847.5113 846.5040 846.3831 0.1209 0 9 11 2 K.QANTEER.K 24403 425.7481 849.4817 849.4709 0.0108 1 60 6.6e-005 1 K.KGGVASGFK.H 27900 437.7747 873.5347 873.5284 0.0064 1 31 0.064 1 R.LKATQVSK.G 28327 441.7340 881.4534 881.4494 0.0040 0 32 0.032 1 K.TASDFITK.M 28328 29102 444.2538 886.4930 886.4872 0.0058 0 62 5e-005 1 K.TGAQELLR.V 29101 31233 457.2965 912.5784 912.5757 0.0027 1 13 2.8 1 R.RTPITVVK.Q 31235 35812 500.2521 998.4897 998.4893 0.0004 0 10 5 1 R.GASQAGAPQGR.V 35826 40135 537.7616 1073.5086 1073.5101 -0.0016 0 23 0.29 1 R.EGGQTAPASTR.L 40525 539.7676 1077.5206 1077.5091 0.0115 0 30 0.061 1 R.YIETDPANR.D 40522 1215 412.2293 1233.6662 1233.6102 0.0560 1 2 85 1 K.RYIETDPANR.D 48683 627.8558 1253.6971 1253.6880 0.0091 1 5 14 2 K.AGKEPGLQIWR.V 49113 633.3198 1264.6251 1264.7027 -0.0775 1 3 24 4 K.AALKTASDFITK.M 49573 638.3672 1274.7197 1274.7095 0.0102 0 39 0.0055 1 K.HVVPNEVVVQR.L 49570 49571 51375 660.3495 1318.6844 1318.6881 -0.0037 0 59 6.6e-005 1 K.AGALNSNDAFVLK.T 51376 19148 52478 675.3253 1348.6360 1348.6371 -0.0011 1 7 10 1 R.YIETDPANRDR.R 52479 57799 915.4919 1828.9692 1828.9571 0.0121 0 66 7.8e-006 1 K.QTQVSVLPEGGETPLFK.Q

50. Q8N1N4|K2C78_HUMAN Mass: 57629 Score: 246 Queries matched: 91 emPAI: 0.21 Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25934 433.7842 865.5539 865.3786 0.1753 0 3 29 3 -.M SLSPCR.A 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.V 30598 30601 30603 30604 30605 30606 30607 30609 306 33231 474.3501 946.6857 946.5018 0.1839 1 10 3.2 3 R.MAKQNLAR.L 33256 36235 502.7557 1003.4969 1003.4934 0.0034 0 40 0.0062 1 R.TQETQEIR.T 36292 503.2397 1004.4648 1004.4597 0.0051 0 47 0.0013 1 R.LLEGEECR.M 36289 36290 36291 36293 36294 36295 36296 36297 36 36427 504.2734 1006.5323 1006.5195 0.0128 1 20 0.57 1 R.ARYEEIAR.S 36428 36430 40163 537.7778 1073.5411 1073.5400 0.0011 1 10 5.4 2 M.SLSPCRAQR.G 40139 40142 40143 40145 40146 40148 40150 40151 4 16992 594.8443 1187.6741 1187.6510 0.0231 1 19 0.58 1 R.LQSQTENLKK.Q 53388 688.8641 1375.7136 1375.7711 -0.0575 1 0 43 3 R.ATLENDFVVLKK.D

51. P06733|ENOA_HUMAN Mass: 47481 Score: 244 Queries matched: 22 emPAI: 0.98 Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20201 403.7381 805.4616 805.4446 0.0170 0 0 64 1 K.YNQLLR.I 30094 450.2862 898.5579 898.5488 0.0092 0 29 0.062 1 K.TIAPALVSK.K 30091 30092 30095 30096 30484 452.7448 903.4750 903.4549 0.0201 0 36 0.016 1 R.IEEELGSK.A 33842 480.2833 958.5520 958.5348 0.0172 1 30 0.058 1 R.NFRNPLAK.- 33867 480.7537 959.4929 959.4924 0.0006 0 12 4.2 4 K.LNVTEQEK.I 11940 504.2679 1006.5213 1006.4940 0.0274 0 28 0.3 1 K.SCNCLLLK.V 37281 514.3147 1026.6148 1026.6437 -0.0289 1 3 26 1 K.TIAPALVSKK.L 37671 517.2733 1032.5320 1032.4771 0.0549 1 12 3.7 4 K.TGAPCRSER.L 14160 542.8319 1083.6491 1083.6223 0.0269 1 3 25 1 -.MSILKIHAR.E 41033 544.8100 1087.6054 1087.5873 0.0181 1 27 0.12 1 K.KLNVTEQEK.I 43772 572.3174 1142.6202 1142.6084 0.0118 0 53 0.00025 1 R.IGAEVYHNLK.N 43770 43773 43777 54139 703.8699 1405.7253 1405.7089 0.0163 0 60 4e-005 1 R.GNPTVEVDLFTSK.G 54555 713.3746 1424.7346 1424.7187 0.0158 0 77 8.6e-007 1 R.YISPDQLADLYK.S 56636 817.4241 1632.8336 1632.8141 0.0195 0 93 1.8e-008 1 K.VNQIGSVTESLQACK.L 14997 556.9869 1667.9390 1667.7746 0.1644 1 1 28 3 K.IDKLMIEMDGTENK.S

52. Q5D862|FILA2_HUMAN Mass: 249296 Score: 236 Queries matched: 13 emPAI: 0.03 Filaggrin-2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15214 560.3396 559.3324 559.3190 0.0133 1 10 11 2 R.TAGRR.G 15151 15205 41222 546.2599 1090.5052 1090.4792 0.0260 0 1 41 5 K.SSGFGQHESR.S 41421 547.7542 1093.4938 1093.4710 0.0228 0 28 0.085 1 K.QDGECGTLSK.G 51406 660.7864 1319.5583 1319.5630 -0.0046 0 67 9.7e-006 1 R.FSNSSSSNEFSK.C 51409 51411 51415 51416 19179 51424 55866 761.3757 1520.7368 1520.7141 0.0227 1 4 16 5 K.QDGECGTLSKGELK.E

53. P13796|PLSL_HUMAN Mass: 70815 Score: 234 Queries matched: 33 emPAI: 0.75 Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20803 406.2139 810.4132 810.4058 0.0074 0 29 0.054 1 K.YAISMAR.K 22179 414.2428 826.4711 826.4007 0.0705 0 (21) 0.41 1 K.YAISMAR.K 22122 1726 22164 22170 1738 22171 22180 32801 471.7751 941.5356 941.5334 0.0021 0 14 1.9 1 R.VNKPPYPK.L 35616 497.7654 993.5163 993.5131 0.0032 0 20 0.57 1 K.IGNFSTDIK.D

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11538 499.7647 997.5148 997.5120 0.0028 0 3 24 3 R.ISFDEFIK.I 41037 545.2459 1088.4772 1088.4557 0.0215 0 24 0.25 1 K.ALENDPDCR.H 41035 41036 15063 559.2963 1116.5780 1116.5750 0.0030 0 10 22 1 K.AACLPLPGYR.V 42465 15444 563.8226 1125.6307 1125.6295 0.0012 1 6 12 2 K.IKVPVDWNR.V 43488 568.3150 1134.6155 1134.6033 0.0122 0 20 0.6 1 R.QFVTATDVVR.G 43484 43493 45615 591.8057 1181.5968 1181.5928 0.0040 1 37 0.0088 1 K.SSSISSFKDPK.I 17992 617.3368 1232.6591 1232.6765 -0.0174 0 2 1.1e+002 2 K.IGLFADIELSR.N 47705 47831 618.2788 1234.5430 1234.5434 -0.0004 0 56 0.00012 1 R.AECMLQQAER.L 51620 442.2310 1323.6711 1323.6670 0.0040 1 16 1.1 1 K.IGNFSTDIKDSK.A 53578 691.8046 1381.5946 1381.5853 0.0092 0 48 0.00066 1 R.GSVSDEEMMELR.E 54198 705.3447 1408.6749 1408.6656 0.0093 0 83 2.3e-007 1 K.LENCNYAVELGK.N 54197 19931 751.8795 1501.7444 1501.7446 -0.0002 0 28 0.07 1 K.MINLSVPDTIDER.T 56356 793.4319 1584.8492 1584.8399 0.0093 0 28 0.059 1 R.VYALPEDLVEVNPK.M 56538 539.9341 1616.7804 1616.7641 0.0163 1 40 0.0045 1 K.TENLNDDEKLNNAK.Y 56931 838.4223 1674.8300 1674.8326 -0.0025 0 77 6.9e-007 1 K.FSLVGIGGQDLNEGNR.T

54. P04406|G3P_HUMAN Mass: 36201 Score: 226 Queries matched: 24 emPAI: 0.49 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20187 403.2246 804.4347 804.4243 0.0104 0 28 0.1 1 K.VGVNGFGR.I 20185 377 20188 20189 26356 435.2658 868.5170 868.5018 0.0152 0 11 3.9 2 K.VIPELNGK.L 26174 26363 26365 39662 533.2637 1064.5128 1064.5839 -0.0711 1 2 36 7 K.AGAHLQGGAKR.V 16205 578.3699 1154.7252 1154.6659 0.0593 1 1 96 1 K.VVKQASEGPLK.G 54308 706.3895 1410.7644 1410.7831 -0.0186 0 43 0.0019 1 R.GALQNIIPASTGAAK.A 19713 54309 54310 54312 19715 54313 5431 19952 765.9001 1529.7857 1529.7872 -0.0015 0 41 0.0029 1 R.VPTANVSVVDLTCR.L 57818 917.4661 1832.9177 1832.9124 0.0053 0 101 2.5e-009 1 K.IISNASCTTNCLAPLAK.V

55. P07355|ANXA2_HUMAN Mass: 38808 Score: 222 Queries matched: 23 emPAI: 0.45 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20424 404.7421 807.4697 807.4603 0.0094 0 25 0.18 1 R.SVPHLQK.V 20423 20425 22158 414.2300 826.4454 826.4337 0.0116 1 8 8.6 1 K.VFDRYK.S 22139 6383 437.3128 872.6111 872.5517 0.0594 1 5 32 4 R.KLMVALAK.G 12765 518.2718 1034.5291 1034.5219 0.0072 0 1 1.6e+002 2 K.WISIMTER.S 12812 518.7808 1035.5471 1035.5349 0.0122 1 21 0.48 1 R.DLYDAGVKR.K 14267 544.3064 1086.5983 1086.5921 0.0062 0 2 1.2e+002 10 R.DALNIETAIK.T 40931 42381 556.2849 1110.5552 1110.5458 0.0094 0 59 6.1e-005 1 R.QDIAFAYQR.R 42378 42379 42380 42383 14971 47174 611.8032 1221.5919 1221.5877 0.0042 0 56 0.00013 1 K.TPAQYDASELK.A 47713 617.3868 1232.7590 1232.5893 0.1697 0 4 19 1 -.MSTVHEILCK.L 48210 622.8187 1243.6228 1243.6156 0.0072 0 52 0.00035 1 R.TNQELQEINR.V 48206 48207 48208 48209

56. P11142|HSP7C_HUMAN Mass: 71082 Score: 216 Queries matched: 21 emPAI: 0.43 Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25451 429.7355 857.4564 857.4494 0.0070 0 24 0.3 1 R.GTLDPVEK.A 25459 25460 32964 472.7661 943.5176 943.5161 0.0015 0 25 0.22 1 K.VCNPIITK.L 32968 33003 35350 495.2658 988.5171 988.5189 -0.0018 1 34 0.023 1 R.LSKEDIER.M 35355 35379 35387 35389 36796 509.2849 1016.5552 1016.5614 -0.0062 1 36 0.017 1 K.ITITNDKGR.L 36794 45488 590.8174 1179.6203 1179.6135 0.0068 1 36 0.013 1 K.VQVEYKGETK.S 45487 46264 600.3418 1198.6691 1198.6670 0.0021 0 35 0.018 1 K.DAGTIAGLNVLR.I 46262 47494 614.8212 1227.6279 1227.6207 0.0072 0 39 0.0075 1 K.VEIIANDQGNR.T 55456 744.3569 1486.6992 1486.6940 0.0052 0 97 8.1e-009 1 R.TTPSYVAFTDTER.L 55453 65598 486.1206 2910.6802 2910.5267 0.1535 0 2 3.2 1 R.NVLIFDLGGGTFDVSILTIEDGIFEVK.S

57. P14618|KPYM_HUMAN Mass: 58470 Score: 197 Queries matched: 20 emPAI: 0.45 Pyruvate kinase isozymes M1/M2 OS=Homo sapiens GN=PKM2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22797 420.7745 839.5344 839.5229 0.0115 0 4 17 4 R.APIIAVTR.N 22793 33402 477.2800 952.5454 952.4726 0.0728 0 3 27 1 K.IENHEGVR.R 36880 510.2652 1018.5159 1018.5083 0.0076 0 28 0.1 1 K.GDYPLEAVR.M 36884 14129 542.3605 1082.7065 1082.6448 0.0618 1 1 59 1 K.GPEIRTGLIK.G 42563 559.8144 1117.6142 1117.5979 0.0163 1 57 9.8e-005 1 K.GSGTAEVELKK.G 42576 43746 571.3187 1140.6229 1140.6026 0.0203 0 27 0.11 1 R.GDLGIEIPAEK.V 43741 43743 15835 15846 46208 599.3486 1196.6826 1196.6401 0.0425 0 42 0.0031 1 R.LDIDSPPITAR.N 46199 49277 634.3325 1266.6505 1266.6060 0.0445 1 0 41 4 K.EMIKSGMNVAR.L 50394 647.3904 1292.7662 1292.7097 0.0565 1 1 36 1 K.VFLAQKMMIGR.C 52785 680.3598 1358.7051 1358.6976 0.0074 0 87 1.1e-007 1 R.NTGIICTIGPASR.S 52789 53908 465.6084 1393.8034 1393.7677 0.0357 1 15 1.2 1 K.IISKIENHEGVR.R

58. P00338|LDHA_HUMAN Mass: 36950 Score: 188 Queries matched: 14 emPAI: 0.34 L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8630 457.3187 912.6229 912.5756 0.0472 0 23 0.41 1 K.LVIITAGAR.Q 43400 567.7904 1133.5663 1133.5564 0.0099 0 59 6.9e-005 1 K.VTLTSEEEAR.L 43391 43396 43397 43398 43401 48323 624.8103 1247.6061 1247.5928 0.0133 0 66 1.3e-005 1 R.VIGSGCNLDSAR.F 48320 48322 49092 632.8479 1263.6812 1263.6711 0.0102 0 33 0.026 1 K.QVVESAYEVIK.L 19317 669.3700 2005.0881 2005.0774 0.0107 0 2 71 2 K.ITVVGVGAVGMACAISILMK.D 19318 669.3902 2005.1487 2005.0774 0.0713 0 (2) 71 1 K.ITVVGVGAVGMACAISILMK.D 19324

59. P12814|ACTN1_HUMAN Mass: 103563 Score: 188 Queries matched: 12 emPAI: 0.23 Alpha-actinin-1 OS=Homo sapiens GN=ACTN1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21817 413.2313 824.4481 824.4392 0.0089 0 23 0.26 1 R.LDHLAEK.F 42440 558.2941 1114.5736 1114.5618 0.0118 1 16 1.5 1 K.ATLPDADKER.L 42445 50387 647.3844 1292.7541 1292.7452 0.0089 0 63 2.2e-005 1 R.LAILGIHNEVSK.I 51645 442.5607 1324.6604 1324.6483 0.0120 1 55 0.00013 1 R.RDQALTEEHAR.Q

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52075 669.8150 1337.6154 1337.6034 0.0120 0 27 0.1 1 K.GISQEQMNEFR.A 19444 677.9021 1353.7897 1353.5983 0.1914 0 (0) 43 1 K.GISQEQMNEFR.A 53698 693.8607 1385.7069 1385.7667 -0.0598 0 8 6.6 2 R.VGWEQLLTTIAR.T 54676 715.3895 1428.7643 1428.7572 0.0071 0 68 6.5e-006 1 R.TINEVENQILTR.D 56011 769.3939 1536.7732 1536.7671 0.0061 0 54 0.00015 1 R.FAIQDISVEETSAK.E 56146 781.3774 1560.7402 1560.7242 0.0160 0 40 0.0043 1 R.ELPPDQAEYCIAR.M 16579 587.2977 1758.8714 1758.8458 0.0256 0 5 51 1 K.MLDAEDIVGTARPDEK.A

60. P54652|HSP72_HUMAN Mass: 70263 Score: 187 Queries matched: 21 emPAI: 0.23 Heat shock-related 70 kDa protein 2 OS=Homo sapiens GN=HSPA2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 30206 450.7752 899.5359 899.5076 0.0283 0 11 4 1 R.VVSEGGKPK.V 30195 7877 36796 509.2849 1016.5552 1016.5614 -0.0062 1 36 0.017 1 K.ITITNDKGR.L 36794 41224 546.2638 1090.5130 1090.4639 0.0491 1 14 2.5 1 K.SEDEANRDR.V 41226 14382 41228 41231 41232 45488 590.8174 1179.6203 1179.6135 0.0068 1 36 0.013 1 K.VQVEYKGETK.T 45487 46495 603.8129 1205.6112 1205.5750 0.0361 0 8 8.4 5 R.MVSHLAEEFK.R 47494 614.8212 1227.6279 1227.6207 0.0072 0 39 0.0075 1 K.VEIIANDQGNR.T 47507 615.3683 1228.7220 1228.6776 0.0444 0 5 18 2 K.DAGTITGLNVLR.I 17883 17885 55456 744.3569 1486.6992 1486.6940 0.0052 0 97 8.1e-009 1 R.TTPSYVAFTDTER.L 55453 65598 486.1206 2910.6802 2910.5267 0.1535 0 2 3.2 1 K.NVLIFDLGGGTFDVSILTIEDGIFEVK.S

61. P09467|F16P1_HUMAN Mass: 37190 Score: 180 Queries matched: 25 emPAI: 0.96 Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18324 630.3501 629.3428 629.3497 -0.0069 1 1 90 2 K.KSPNGK.L 22342 416.2658 830.5171 830.4974 0.0197 1 29 0.086 1 K.AISSAVRK.A 22338 22339 22340 2180 28467 442.2017 882.3889 882.3905 -0.0017 0 15 1.4 1 R.FVMEEGR.K 35648 498.2552 994.4959 994.4906 0.0053 1 40 0.0047 1 R.FVMEEGRK.A 35647 35650 35653 36482 506.2956 1010.5767 1010.4855 0.0912 1 (2) 31 1 R.FVMEEGRK.A 12071 44409 579.3043 1156.5941 1156.5764 0.0177 0 35 0.018 1 K.IYSLNEGYAK.D 44397 44399 44401 44403 48334 417.2155 1248.6248 1248.5921 0.0326 0 9 6.2 1 R.YVGSMVADVHR.T 54999 727.3498 1452.6851 1452.6885 -0.0034 0 71 3.3e-006 1 K.DFDPAVTEYIQR.K 55001 56487 535.9662 1604.8767 1604.8522 0.0245 0 22 0.21 1 K.EAVLDVIPTDIHQR.A 56624 543.9368 1628.7887 1628.7642 0.0245 1 40 0.0044 1 K.STDEPSEKDALQPGR.N 56623 59836 734.0738 2199.1997 2199.1648 0.0349 1 34 0.01 1 R.KAGIAHLYGIAGSTNVTGDQVK.K

62. P17066|HSP76_HUMAN Mass: 71440 Score: 172 Queries matched: 14 emPAI: 0.16 Heat shock 70 kDa protein 6 OS=Homo sapiens GN=HSPA6 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 30206 450.7752 899.5359 899.5076 0.0283 0 11 4 1 R.VVSEGGKPK.V 30195 7877 30349 451.7470 901.4795 901.4756 0.0038 0 21 0.61 1 R.STLEPVEK.A 35350 495.2658 988.5171 988.5189 -0.0018 1 21 0.49 2 R.LSKEEVER.M 35355 35387 35389 36796 509.2849 1016.5552 1016.5614 -0.0062 1 36 0.017 1 K.ITITNDKGR.L 36794 44367 578.3540 1154.6934 1154.6772 0.0163 1 0 40 3 R.VVSEGGKPKVR.V 47494 614.8212 1227.6279 1227.6207 0.0072 0 39 0.0075 1 R.VEILANDQGNR.T 55456 744.3569 1486.6992 1486.6940 0.0052 0 97 8.1e-009 1 R.TTPSYVAFTDTER.L 55453

63. P25774|CATS_HUMAN Mass: 38099 Score: 164 Queries matched: 12 emPAI: 0.33 Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7183 444.2622 886.5098 886.4548 0.0549 1 2 1.6e+002 1 K.TYGKQYK.E 33516 478.7679 955.5213 955.5087 0.0126 0 45 0.0016 1 K.GPVSVGVDAR.H 33512 33513 35781 499.7533 997.4920 997.4869 0.0051 0 9 5.8 1 K.YTELPYGR.E 38744 525.3204 1048.6262 1048.5223 0.1039 1 1 47 1 R.EKGCVTEVK.Y 13744 533.7789 1065.5433 1065.5396 0.0037 0 17 0.95 1 R.HPSFFLYR.S 46477 603.8018 1205.5890 1205.6153 -0.0263 1 0 49 3 R.NITYKSNPNR.I 46886 608.2844 1214.5541 1214.5455 0.0086 0 63 2.6e-005 1 K.GIDSDASYPYK.A 46887 46904 56264 784.9296 1567.8446 1567.8318 0.0128 1 62 2.5e-005 1 K.EAVANKGPVSVGVDAR.H

64. Q9BYX7|ACTBM_HUMAN Mass: 42331 Score: 163 Queries matched: 10 emPAI: 0.19 Beta-actin-like protein 3 OS=Homo sapiens GN=ACTBL3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15337 562.2869 561.2796 561.2758 0.0038 0 2 50 8 K.EAQSK.R 18752 644.3690 643.3618 643.3653 -0.0035 0 18 2.4 1 R.LDLAGR.E 18746 45744 595.3200 1188.6254 1188.6424 -0.0170 0 13 3.1 1 K.EITALAPSIMK.I 45740 51215 657.3151 1312.6156 1312.5475 0.0682 0 4 17 2 R.HQGMMEGMHQK.E 55814 506.2547 1515.7422 1515.6954 0.0468 0 43 0.0021 1 K.QEYDESGPSIVHR.K 12072 57488 895.9609 1789.9073 1789.8846 0.0227 0 111 2.9e-010 1 K.SYELPDGQVITIGNER.F 57489

65. P07737|PROF1_HUMAN Mass: 15216 Score: 159 Queries matched: 9 emPAI: 2.13 Profilin-1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6392 437.7718 873.5289 873.5358 -0.0068 0 42 0.0047 1 K.TLVLLMGK.E 37130 512.2846 1022.5547 1022.5509 0.0038 0 45 0.0015 1 K.EGVHGGLINK.K 44235 576.3331 1150.6516 1150.6458 0.0057 1 43 0.0025 1 K.EGVHGGLINKK.C 46844 607.3242 1212.6338 1212.6139 0.0199 0 38 0.0074 1 K.DSPSVWAAVPGK.T 47002 406.9095 1217.7066 1217.7053 0.0012 1 7 12 1 K.TDKTLVLLMGK.E 53456 690.3712 1378.7278 1378.7093 0.0186 0 57 0.0001 1 K.STGGAPTFNVTVTK.T 53452 53453 53454

66. P29401|TKT_HUMAN Mass: 68519 Score: 158 Queries matched: 17 emPAI: 0.70 Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16631 588.2841 587.2768 587.3755 -0.0987 1 4 77 7 K.IATRK.A 21545 411.2309 820.4472 820.4443 0.0029 0 31 0.051 1 K.AYGQALAK.L 24086 422.2401 842.4657 842.4610 0.0047 0 20 0.62 1 R.DAIAQAVR.G 24088

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25495 430.2552 858.4958 858.4923 0.0035 1 10 7.1 1 K.VGDKIATR.K 31473 458.2895 914.5644 914.5549 0.0095 1 35 0.018 1 R.KLILDSAR.A 31479 458.7602 915.5057 915.5025 0.0032 0 43 0.0029 1 K.AVELAANTK.G 31634 461.7391 921.4636 921.4630 0.0006 0 0 48 9 R.MPSLPSYK.V 32804 471.7863 941.5581 941.5545 0.0035 0 44 0.0023 1 R.SGKPAELLK.M 33291 475.2766 948.5386 948.5392 -0.0006 1 49 0.00083 1 R.KAYGQALAK.L 34838 489.7986 977.5826 977.5658 0.0168 0 22 0.36 1 K.HQPTAIIAK.T 43141 565.3174 1128.6203 1128.6251 -0.0048 1 44 0.0023 1 K.LQALKDTANR.L 46308 600.8171 1199.6197 1199.6186 0.0011 1 14 2.1 1 K.NSTFSEIFKK.E 49081 422.2291 1263.6654 1263.6459 0.0195 0 26 0.11 1 K.ISSDLDGHPVPK.Q 4774 432.2843 1293.8310 1293.7768 0.0542 1 7 66 1 R.VPRSGKPAELLK.M 57945 942.9638 1883.9131 1883.9153 -0.0022 0 41 0.0027 1 R.SVPTSTVFYPSDGVATEK.A 58553 674.0279 2019.0618 2019.0636 -0.0018 0 33 0.014 1 K.ILATPPQEDAPSVDIANIR.M

67. O43933|PEX1_HUMAN Mass: 143804 Score: 158 Queries matched: 53 emPAI: 0.05 Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24319 424.7464 847.4782 847.4763 0.0019 1 12 4.4 1 K.GSGKSTLAK.A 24306 24307 24308 24315 24323 24326 24333 31235 457.2987 912.5829 912.5756 0.0073 0 8 9.1 2 K.TLLAGVIAR.E 39641 533.2468 1064.4791 1064.5358 -0.0567 1 45 0.0018 2 K.GMMKELQTK.Q 39642 39643 39644 39645 39646 39647 39648 39649 3 40702 541.2558 1080.4971 1080.5307 -0.0336 1 (41) 0.0041 2 K.GMMKELQTK.Q 40693 40695 40696 40697 40698 40699 40700 40701 4 41341 547.2645 1092.5144 1092.5564 -0.0419 0 1 40 8 K.YIGASEQAVR.D 41470 549.2536 1096.4925 1096.5257 -0.0331 1 (7) 8.7 1 K.GMMKELQTK.Q 41469 53252 686.2898 1370.5650 1370.6062 -0.0412 1 5 12 8 K.IRSDHNEEDEK.A 53245 9401 467.3052 1398.8937 1398.8235 0.0702 0 3 48 2 K.NIFLLSPNLLQK.T

68. P08238|HS90B_HUMAN Mass: 83554 Score: 144 Queries matched: 23 emPAI: 0.30 Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22257 415.2634 828.5123 828.5221 -0.0098 0 25 0.22 1 R.ALLFIPR.R 1952 25555 432.2213 862.4279 862.4218 0.0061 0 3 36 3 R.EMLQQSK.I 10148 476.2835 950.5524 950.4570 0.0954 0 0 1.8e+002 2 R.ADHGEPIGR.G 36450 505.2662 1008.5179 1008.5062 0.0117 1 17 1 1 K.AKFENLCK.L 38234 523.2900 1044.5654 1044.5927 -0.0273 1 9 7.7 4 K.VEKVTISNR.L 38188 38190 38232 38279 38334 38341 44206 576.2901 1150.5656 1150.5506 0.0150 0 28 0.083 1 K.YIDQEELNK.T 44205 18160 621.8597 1241.7048 1241.6979 0.0069 0 55 0.00016 1 K.ADLINNLGTIAK.S 48333 625.3148 1248.6149 1248.6098 0.0051 0 49 0.00066 1 K.EQVANSAFVER.V 19394 675.3751 1348.7356 1348.7272 0.0084 0 31 0.14 1 R.TLTLVDTGIGMTK.A 19500 683.4052 1364.7958 1364.7221 0.0737 0 (3) 49 1 R.TLTLVDTGIGMTK.A 53023 53829 696.8113 1391.6080 1391.5883 0.0197 1 (1) 33 6 R.DNSTMGYMMAKK.H 9209 464.9341 1391.7804 1391.5883 0.1921 1 1 31 3 R.DNSTMGYMMAKK.H 55783 757.4047 1512.7949 1512.7784 0.0165 0 77 8.4e-007 1 R.GVVDSEDLPLNISR.E 57999 955.9353 1909.8561 1910.0374 -0.1813 1 1 26 8 K.KHLEINPDHPIVETLR.Q

69. Q562R1|ACTBL_HUMAN Mass: 42318 Score: 141 Queries matched: 27 emPAI: 0.53 Beta-actin-like protein 2 OS=Homo sapiens GN=ACTBL2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18752 644.3690 643.3618 643.3653 -0.0035 0 18 2.4 1 R.LDLAGR.D 18746 30496 453.2357 904.4567 904.4436 0.0131 1 28 0.099 1 K.CDVDIRK.D 31681 462.2932 922.5718 922.5600 0.0118 1 25 0.16 1 K.IIAPPERK.Y 31673 31676 31677 31678 31680 11537 499.7568 997.4990 997.4790 0.0200 0 (19) 0.62 1 R.DLTDYLMK.I 11534 36558 507.7536 1013.4926 1013.4739 0.0187 0 24 0.22 1 R.DLTDYLMK.I 36557 37848 518.8400 1035.6653 1035.6440 0.0213 1 22 0.32 1 K.IKIIAPPER.K 37847 12816 16281 580.2626 1158.5107 1158.5305 -0.0198 0 3 60 1 R.GYNFTTTAER.E 45029 586.2867 1170.5588 1170.5638 -0.0050 0 24 0.21 1 R.HQGVMVGMGQK.D 45031 46380 602.3015 1202.5884 1202.5536 0.0348 0 (16) 1.5 1 R.HQGVMVGMGQK.D 57488 895.9609 1789.9073 1789.8846 0.0227 0 111 2.9e-010 1 R.SYELPDGQVITIGNER.F 57489 58209 652.0394 1953.0965 1953.0571 0.0394 0 26 0.06 1 R.VAPDEHPILLTEAPLNPK.I 18998 18999 19000 58210

70. O43707|ACTN4_HUMAN Mass: 105245 Score: 141 Queries matched: 14 emPAI: 0.23 Alpha-actinin-4 OS=Homo sapiens GN=ACTN4 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21050 406.2591 810.5037 810.4963 0.0074 0 16 1.2 1 K.VQQLVPK.R 21817 413.2313 824.4481 824.4392 0.0089 0 23 0.26 1 R.LDHLAEK.F 7530 447.7769 893.5392 893.5334 0.0058 0 35 0.018 1 R.EAILAIHK.E 30967 456.2585 910.5024 910.4872 0.0152 0 12 3.1 1 R.IAESNHIK.L 31694 462.7150 923.4155 923.5552 -0.1397 1 2 28 6 R.LPKPERGK.M 36316 503.2613 1004.5080 1004.4961 0.0119 0 4 26 8 K.TIQEMQQK.L 37375 515.2988 1028.5830 1028.5291 0.0540 0 3 26 2 R.TIPWLEDR.V 44460 580.2942 1158.5739 1158.5629 0.0110 1 30 0.052 1 K.STLPDADRER.E 44459 44462 53698 693.8607 1385.7069 1385.7667 -0.0598 0 8 6.6 2 R.VGWEQLLTTIAR.T 54676 715.3895 1428.7643 1428.7572 0.0071 0 68 6.5e-006 1 R.TINEVENQILTR.D 56011 769.3939 1536.7732 1536.7671 0.0061 0 54 0.00015 1 R.FAIQDISVEETSAK.E 56146 781.3774 1560.7402 1560.7242 0.0160 0 40 0.0043 1 R.ELPPDQAEYCIAR.M

71. P31946|1433B_HUMAN Mass: 28179 Score: 131 Queries matched: 11 emPAI: 0.66 14-3-3 protein beta/alpha OS=Homo sapiens GN=YWHAB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7978 452.2556 902.4966 902.5073 -0.0106 0 26 0.36 1 R.VISSIEQK.T 30673 454.2644 906.5143 906.5174 -0.0031 0 33 0.033 1 R.NLLSVAYK.N 30674 30676 30679 12179 508.2210 1014.4274 1014.4150 0.0124 0 1 1.2e+002 6 R.YDDMAAAMK.A 42225 554.7760 1107.5374 1107.5495 -0.0121 0 19 0.61 1 K.EMQPTHPIR.L 45613 591.7813 1181.5480 1181.5564 -0.0084 0 39 0.0063 1 R.YLSEVASGDNK.Q 56445 799.8633 1597.7120 1597.7332 -0.0212 0 73 2.1e-006 1 K.AVTEQGHELSNEER.N 56446 56447

72. P52790|HXK3_HUMAN Mass: 100616 Score: 122 Queries matched: 14 emPAI: 0.16

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Hexokinase-3 OS=Homo sapiens GN=HK3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 33377 477.2660 952.5174 952.5090 0.0084 0 35 0.016 1 R.GQASPAPAVR.M 33400 37284 514.7661 1027.5177 1027.5047 0.0130 0 20 0.52 1 R.NVAGVPGDSGR.M 38266 523.2939 1044.5732 1044.5676 0.0056 1 4 24 8 K.GLRGEASSLR.M 38210 38221 38261 13156 38331 38766 525.8048 1049.5949 1049.5869 0.0080 0 47 0.0011 1 R.FSSLVAATVR.E 45707 594.8404 1187.6662 1187.6550 0.0112 0 57 9.9e-005 1 R.LLEETLAPFR.L 49207 633.8369 1265.6592 1265.6476 0.0116 1 2 27 1 R.HVAVLDEDRGR.V 49253 54874 722.3810 1442.7474 1442.7551 -0.0077 0 58 7.3e-005 1 R.AAQLCGAGVAAVVEK.I

73. P07900|HS90A_HUMAN Mass: 85006 Score: 122 Queries matched: 17 emPAI: 0.24 Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21439 408.2640 814.5134 814.5065 0.0069 0 32 0.038 1 R.ALLFVPR.R 25555 432.2213 862.4279 862.4218 0.0061 0 3 36 3 R.EMLQQSK.I 34368 486.2682 970.5218 970.6076 -0.0858 1 2 37 3 R.ALLFVPRR.A 36316 503.2613 1004.5080 1004.5576 -0.0496 1 9 7.3 1 K.IMKDILEK.K 44206 576.2901 1150.5656 1150.5506 0.0150 0 28 0.083 1 K.YIDQEELNK.T 44205 45008 584.7949 1167.5752 1167.5632 0.0120 0 30 0.05 1 K.LGIHEDSQNR.K 45009 18160 621.8597 1241.7048 1241.6979 0.0069 0 55 0.00016 1 K.ADLINNLGTIAK.S 4918 432.8784 1295.6134 1295.6582 -0.0448 1 3 22 1 K.LGIHEDSQNRK.K 5289 50551 19394 675.3751 1348.7356 1348.7272 0.0084 0 31 0.14 1 R.TLTIVDTGIGMTK.A 19500 683.4052 1364.7958 1364.7221 0.0737 0 (3) 49 1 R.TLTIVDTGIGMTK.A 53023 55783 757.4047 1512.7949 1512.7784 0.0165 0 77 8.4e-007 1 R.GVVDSEDLPLNISR.E 56144 780.8870 1559.7595 1559.8155 -0.0559 1 3 20 2 R.ELISNSSDALDKIR.Y

74. Q13231|CHIT1_HUMAN Mass: 52219 Score: 122 Queries matched: 7 emPAI: 0.32 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 36041 501.7635 1001.5125 1001.4930 0.0195 0 30 0.067 1 K.ADGLYPNPR.E 11747 502.2723 1002.5300 1002.5862 -0.0562 0 18 3.1 1 R.YPLIQTLR.Q 37765 518.2936 1034.5726 1034.5509 0.0217 0 16 1.3 1 R.QTFVNSAIR.F 41913 553.2489 1104.4833 1104.4658 0.0174 0 54 0.00021 1 R.SSFYSCAAGR.L 42442 558.2955 1114.5764 1114.5771 -0.0007 0 19 0.73 1 K.VTGHNSPLYK.R 45030 586.2915 1170.5684 1170.5517 0.0167 0 47 0.0011 1 R.SFTLASSSDTR.V 54915 722.8845 1443.7544 1443.7358 0.0186 0 74 1.9e-006 1 R.VGAPATGSGTPGPFTK.E

75. P61981|1433G_HUMAN Mass: 28456 Score: 121 Queries matched: 13 emPAI: 0.87 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7978 452.2556 902.4966 902.5073 -0.0106 0 26 0.36 1 R.VISSIEQK.T 30673 454.2644 906.5143 906.5174 -0.0031 0 33 0.033 1 R.NLLSVAYK.N 30674 30676 30679 10090 475.2949 948.5752 948.4764 0.0988 0 3 1.1e+002 2 R.ATVVESSEK.A 34411 486.2781 970.5416 970.5560 -0.0143 1 2 34 1 R.EQLVQKAR.L 12179 508.2210 1014.4274 1014.4150 0.0124 0 1 1.2e+002 6 R.YDDMAAAMK.N 40671 540.7789 1079.5433 1079.5499 -0.0066 0 40 0.0055 1 R.YLAEVATGEK.R 43389 567.7743 1133.5341 1133.5353 -0.0012 0 37 0.011 1 K.AYSEAHEISK.E 47892 412.8883 1235.6430 1235.6510 -0.0080 1 14 1.7 1 R.YLAEVATGEKR.A 56682 822.3940 1642.7734 1642.7798 -0.0064 0 58 5.5e-005 1 K.NVTELNEPLSNEER.N 56681

76. P07195|LDHB_HUMAN Mass: 36900 Score: 119 Queries matched: 6 emPAI: 0.21 L-lactate dehydrogenase B chain OS=Homo sapiens GN=LDHB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 31019 457.2103 912.4060 912.5757 -0.1696 0 15 1.8 1 K.IVVVTAGVR.Q 33841 480.2832 958.5518 958.5447 0.0071 0 32 0.036 1 R.GLTSVINQK.L 33806 48323 624.8103 1247.6061 1247.5928 0.0133 0 66 1.3e-005 1 R.VIGSGCNLDSAR.F 48320 48322

77. P62988|UBIQ_HUMAN Mass: 8560 Score: 118 Queries matched: 12 emPAI: 3.77 Ubiquitin OS=Homo sapiens GN=RPS27A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13786 534.3135 1066.6125 1066.6135 -0.0010 0 32 0.1 1 K.ESTLHLVLR.L 40718 541.2861 1080.5576 1080.5451 0.0125 0 25 0.16 1 R.TLSDYNIQK.E 40713 40715 40716 7408 446.2338 1335.6797 1335.7986 -0.1190 1 1 1.9e+002 3 K.ESTLHLVLRLR.G 55889 762.4006 1522.7867 1522.7740 0.0127 1 47 0.00073 1 K.IQDKEGIPPDQQR.L 55890 55891 55892 55893 57483 894.4778 1786.9411 1786.9200 0.0211 0 67 7.2e-006 1 K.TITLEVEPSDTIENVK.A

78. P52209|6PGD_HUMAN Mass: 53619 Score: 115 Queries matched: 9 emPAI: 0.22 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20114 401.2497 800.4848 800.4756 0.0092 0 6 16 5 K.VVGAQSLK.E 24895 427.8198 853.6249 853.6113 0.0137 1 16 0.83 2 R.RIILLVK.A 34969 492.7503 983.4861 983.4713 0.0149 1 20 0.52 1 K.FQFDGDKK.S 11947 504.2805 1006.5465 1006.5447 0.0018 1 19 2.6 1 K.SFLEDIRK.A 42738 561.2884 1120.5621 1120.5400 0.0221 0 20 0.53 1 K.VDDFLANEAK.G 45882 596.8054 1191.5963 1191.5772 0.0191 0 54 0.00021 1 K.AGQAVDDFIEK.L 8766 459.2686 1374.7840 1374.7541 0.0300 1 6 66 1 K.VVGAQSLKEMVSK.L 53972 466.9208 1397.7407 1397.7303 0.0104 1 7 8.8 2 K.FQDTDGKHLLPK.I 56400 796.4173 1590.8201 1590.8002 0.0199 0 83 1.8e-007 1 K.GILFVGSGVSGGEEGAR.Y

79. P68871|HBB_HUMAN Mass: 16102 Score: 114 Queries matched: 8 emPAI: 1.38 Hemoglobin subunit beta OS=Homo sapiens GN=HBB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 32371 466.7665 931.5184 931.5127 0.0057 0 40 0.0066 1 K.SAVTALWGK.V 33356 476.7593 951.5041 951.5025 0.0016 0 33 0.027 1 M.VHLTPEEK.S 18612 637.8678 1273.7211 1273.7183 0.0028 0 25 0.15 1 R.LLVVYPWTQR.F 3713

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51269 657.8385 1313.6625 1313.6575 0.0050 0 51 0.00034 1 K.VNVDEVGGEALGR.L 51268 53443 689.8560 1377.6974 1377.6929 0.0046 0 65 1.7e-005 1 K.EFTPPVQAAYQK.V 67622 666.9501 3329.7141 3329.6431 0.0710 1 1 9.4 2 R.LLVVYPWTQRFFESFGDLSTPDAVM GNPK.V

80. P28072|PSB6_HUMAN Mass: 25570 Score: 110 Queries matched: 5 emPAI: 0.32 Proteasome subunit beta type-6 OS=Homo sapiens GN=PSMB6 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9386 467.2787 932.5428 932.5113 0.0315 0 2 78 2 -.MAATLLAAR.G 9374 40815 542.2783 1082.5421 1082.5356 0.0065 0 57 9.9e-005 1 R.TTTGSYIANR.V 40814 42447 558.3198 1114.6251 1114.5982 0.0269 0 55 0.00016 1 R.LAAIAESGVER.Q

81. P17900|SAP3_HUMAN Mass: 21281 Score: 110 Queries matched: 9 emPAI: 0.39 Ganglioside GM2 activator OS=Homo sapiens GN=GM2A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21423 408.2536 814.4926 814.4800 0.0126 0 16 1.8 1 K.VDLVLEK.E 7526 447.7391 893.4636 893.4494 0.0141 0 12 3.7 1 K.EGTYSLPK.S 7525 36419 503.7779 1005.5413 1005.5342 0.0071 0 57 0.00011 1 R.IESVLSSSGK.R 44682 581.8358 1161.6571 1161.6353 0.0218 1 59 7.3e-005 1 R.IESVLSSSGKR.L 44664 8907 460.4906 1378.4500 1378.6162 -0.1663 0 5 12 1 R.TYGLPCHCPFK.E 8906 8908

82. Q6ZMR3|LDH6A_HUMAN Mass: 36826 Score: 109 Queries matched: 5 emPAI: 0.10 L-lactate dehydrogenase A-like 6A OS=Homo sapiens GN=LDHAL6A PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 48323 624.8103 1247.6061 1247.5928 0.0133 0 66 1.3e-005 1 R.VIGSGCNLDSAR.F 48320 48322 54187 705.3342 1408.6539 1408.6735 -0.0196 1 5 14 6 K.DPEQWENVHKK.V 54194

83. P08758|ANXA5_HUMAN Mass: 35971 Score: 107 Queries matched: 9 emPAI: 0.49 Annexin A5 OS=Homo sapiens GN=ANXA5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 29233 447.2452 892.4758 892.4654 0.0104 0 29 0.075 1 R.QEISAAFK.T 11671 501.2799 1000.5452 1000.5917 -0.0464 0 25 0.63 1 K.VLTEIIASR.T 36561 507.7651 1013.5156 1013.5069 0.0087 0 26 0.14 1 R.LYDAYELK.H 43062 564.2876 1126.5607 1126.6896 -0.1289 0 0 45 5 K.LIVALMKPSR.L 44359 578.2933 1154.5721 1154.5680 0.0041 0 53 0.00025 1 K.GAGTDDHTLIR.V 44358 44360 45058 586.8292 1171.6439 1171.6747 -0.0308 0 6 13 2 R.MLVVLLQANR.D 50229 645.8137 1289.6129 1289.6326 -0.0196 0 1 35 10 K.NFATSLYSMIK.G

84. Q9H299|SH3L3_HUMAN Mass: 10488 Score: 106 Queries matched: 6 emPAI: 0.92 SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 38980 528.7753 1055.5360 1055.5248 0.0113 0 51 0.0005 1 R.VYSTSVTGSR.E 13336 38978 38979 46345 401.2400 1200.6982 1200.5921 0.1061 1 5 16 5 R.DEMRALAGNPK.A 50833 652.8503 1303.6860 1303.6732 0.0128 1 43 0.0027 1 R.EIKSQQSEVTR.I

85. P41219|PERI_HUMAN Mass: 53732 Score: 106 Queries matched: 23 emPAI: 0.14 Peripherin OS=Homo sapiens GN=PRPH PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17298 601.3194 600.3121 600.3231 -0.0110 0 7 14 1 R.LPSER.L 30484 452.7448 903.4750 903.4661 0.0089 1 22 0.46 3 R.LEEETRK.R 30787 455.2478 908.4810 908.3658 0.1153 0 1 42 1 K.QEMNESR.R 32348 466.7458 931.4770 931.4610 0.0160 0 33 0.03 1 K.LLEGEESR.I 9328 9329 32342 9330 32345 32346 13389 529.3397 1056.6648 1056.5134 0.1513 1 4 59 2 K.EEMARHLR.E 13359 39267 530.7964 1059.5782 1059.5560 0.0222 1 49 0.00082 1 R.KLLEGEESR.I 39219 39220 39221 39224 39238 39241 42432 557.8051 1113.5957 1113.6142 -0.0185 1 10 5.9 10 R.ELELLGRER.D 42440 558.2941 1114.5736 1114.5870 -0.0134 0 3 29 4 R.DGLAEDLAALK.Q 51021 655.3285 1308.6425 1308.5986 0.0439 0 6 12 1 K.NLQEAEEWYK.S 56428 797.8826 1593.7506 1593.8324 -0.0817 1 7 6.9 10 K.IESLMDEIEFLKK.L

86. P17661|DESM_HUMAN Mass: 53560 Score: 106 Queries matched: 26 emPAI: 0.22 Desmin OS=Homo sapiens GN=DES PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18780 645.3504 644.3431 644.3493 -0.0062 0 0 1.6e+002 1 R.IDLER.R 30793 455.2488 908.4831 908.4022 0.0809 0 3 29 3 K.GTNDSLMR.Q 32348 466.7458 931.4770 931.4610 0.0160 0 33 0.03 1 K.LLEGEESR.I 9328 9329 32342 9330 32345 32346 35907 500.8146 999.6147 999.5600 0.0547 0 13 3 9 K.LQEEIQLK.E 39267 530.7964 1059.5782 1059.5560 0.0222 1 49 0.00082 1 R.KLLEGEESR.I 39219 39220 39221 39224 39238 39241 15260 561.3076 1120.6006 1120.5764 0.0242 0 19 2.7 1 R.EYQDLLNVK.M 15263 46600 604.3498 1206.6851 1206.6642 0.0209 1 6 13 1 K.TVMIKTIETR.D 51224 657.3699 1312.7253 1312.5903 0.1350 1 4 17 10 R.QAKQEMMEYR.H 51223 51225 57271 868.9666 1735.9187 1735.7948 0.1240 1 7 7.4 1 -.MSQAYSSSQRVSSYR.R 57270 57276

87. P21333|FLNA_HUMAN Mass: 283301 Score: 104 Queries matched: 36 emPAI: 0.04 Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13313 528.3279 527.3206 527.3067 0.0139 0 8 16 1 K.VQGPK.G 24184 423.1798 844.3451 844.4290 -0.0839 0 3 39 1 R.AVPTGDASK.C 24216 31729 463.2543 924.4939 924.5505 -0.0565 1 0 45 5 R.AVGRGLQPK.G 32512 469.2562 936.4978 936.4916 0.0061 1 12 2.9 1 R.VKETADFK.V 34374 486.2694 970.5242 970.5600 -0.0358 0 1 48 2 R.LLGWIQNK.L 35274 494.7830 987.5515 987.5349 0.0166 1 26 0.16 1 K.KGEITGEVR.M 35267 36545 507.2959 1012.5772 1012.5665 0.0106 1 25 0.14 1 K.VKAEGPGLSR.T 36514 37454 516.2797 1030.5448 1030.5155 0.0293 1 22 0.38 1 K.VTANNDKNR.T 37446 37448 37449 37450 37451 37452 37456 3745 13219 525.2782 1048.5418 1048.5375 0.0043 0 (9) 17 9 R.LSPFMADIR.D 13713 533.2910 1064.5675 1064.5325 0.0351 0 9 25 3 R.LSPFMADIR.D

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40549 540.2836 1078.5526 1078.5520 0.0007 0 62 3.4e-005 1 R.VNVGAGSHPNK.V 40555 41433 547.8048 1093.5949 1093.5404 0.0546 1 2 29 5 K.AEISFEDRK.D 14565 14684 550.2803 1098.5460 1098.5669 -0.0209 0 24 0.56 1 K.GTVEPQLEAR.G 42228 554.8058 1107.5970 1107.6037 -0.0066 0 18 0.74 1 R.ALTQTGGPHVK.A 52937 682.9048 1363.7950 1363.6984 0.0966 1 1 33 2 K.VDVGKDQEFTVK.S 52935 54675 715.3702 1428.7258 1428.7110 0.0148 0 62 3.1e-005 1 K.AFGPGLQGGSAGSPAR.F

88. P26038|MOES_HUMAN Mass: 67892 Score: 104 Queries matched: 39 emPAI: 0.53 Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20710 405.7025 809.3904 809.3919 -0.0015 0 32 0.031 1 K.SGYLAGDK.L 2161 416.3030 830.5914 830.4359 0.1556 1 18 5.9 5 R.QGNTKQR.I 2139 2155 22351 2167 2183 2192 2197 2198 22366 220 22397 417.2434 832.4722 832.4694 0.0028 0 21 0.53 1 K.ESPLLFK.F 7150 444.2542 886.4939 886.4872 0.0067 0 14 11 1 K.EALLQASR.D 29254 447.7736 893.5325 893.5375 -0.0049 0 8 8.4 1 R.LFFLQVK.E 31483 458.7698 915.5251 915.5138 0.0113 1 53 0.00033 1 K.VTAQDVRK.E 33145 474.2557 946.4968 946.4906 0.0062 0 34 0.024 1 R.ISQLEMAR.Q 34064 482.2526 962.4906 962.4855 0.0051 0 (19) 0.71 1 R.ISQLEM AR.Q 34196 483.2583 964.5021 964.4978 0.0043 1 10 5.7 1 R.NISFNDKK.F 34198 35176 494.2603 986.5061 986.5032 0.0028 0 35 0.018 1 R.ALELEQER.K 35177 35183 38229 523.2896 1044.5647 1044.5563 0.0084 0 13 3.2 1 K.ALTSELANAR.D 39466 532.2642 1062.5138 1062.5015 0.0123 1 23 0.29 1 R.EKEELMER.L 40210 537.7956 1073.5767 1073.5716 0.0051 1 24 0.26 1 R.AQSEAEKLAK.E 40226 40550 540.2852 1078.5558 1078.5546 0.0012 0 10 5.3 1 R.EDAVLEYLK.I 14260 544.3018 1086.5890 1086.6801 -0.0911 1 17 3.7 1 K.FVIKPIDKK.A 42446 558.3072 1114.5998 1114.5982 0.0016 1 9 7.3 3 R.ALELEQERK.R 42455 558.8162 1115.6178 1115.6186 -0.0008 1 17 0.98 1 R.LKQIEEQTK.K 43769 572.3149 1142.6153 1142.6043 0.0109 1 23 0.29 1 R.RALELEQER.K 16869 591.8020 1181.5894 1181.5869 0.0024 0 25 0.16 1 K.APDFVFYAPR.L 47546 616.3070 1230.5994 1230.5840 0.0154 0 47 0.0012 1 K.AQQELEEQTR.R 47638 617.2941 1232.5736 1232.5673 0.0063 0 24 0.21 1 K.ESEAVEWQQK.A 47891 412.8752 1235.6037 1235.5935 0.0103 1 8 8 1 K.YGDFNKEVHK.S 53423 689.8145 1377.6144 1377.6380 -0.0236 1 7 8.3 1 K.QMERAMLENEK.K 55720 752.8890 1503.7634 1503.7529 0.0106 1 6 12 3 K.ALTSELANARDESK.K

89. P02751|FINC_HUMAN Mass: 266034 Score: 100 Queries matched: 17 emPAI: 0.07 Fibronectin OS=Homo sapiens GN=FN1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17481 604.3189 603.3116 603.2612 0.0504 0 5 57 2 R.DGQER.D 20384 404.7217 807.4289 807.4239 0.0050 0 11 4.8 1 R.AQITGYR.L 20385 22197 414.7547 827.4947 827.4865 0.0083 0 22 0.39 1 R.TIKPDVR.S 4315 429.7255 857.4364 857.4243 0.0121 0 26 0.17 1 R.SDTVPSPR.D 25450 27624 436.7399 871.4652 871.4664 -0.0013 0 29 0.079 1 K.VFAVSHGR.E 11417 498.2849 994.5552 994.4944 0.0608 1 4 52 2 R.EDRVPHSR.N 39603 532.7774 1063.5402 1063.5298 0.0104 0 36 0.014 1 R.VGDTYERPK.D 42339 555.7799 1109.5451 1109.5353 0.0098 0 18 0.77 1 R.STTPDITGYR.I 45090 587.7875 1173.5604 1173.4478 0.1126 0 6 14 8 K.QHDMGHMMR.C 6550 440.2766 1317.8079 1317.6387 0.1692 0 9 20 1 K.GEWTCKPIAEK.C 51609 441.9089 1322.7050 1322.7055 -0.0005 0 23 0.23 1 K.LGVRPSQGGEAPR.E 51614 54098 701.3401 1400.6656 1400.6585 0.0070 0 2 31 7 K.HYQINQQWER.T 55146 731.4031 1460.7916 1460.7835 0.0081 0 48 0.00067 1 R.VPGTSTSATLTGLTR.G 56039 772.3937 1542.7729 1542.7566 0.0163 0 42 0.0023 1 R.SYTITGLQPGTDYK.I

90. P40121|CAPG_HUMAN Mass: 38779 Score: 98 Queries matched: 10 emPAI: 0.45 Macrophage-capping protein OS=Homo sapiens GN=CAPG PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18971 650.3247 649.3174 649.3799 -0.0625 0 9 19 2 K.LYQVK.G 18973 18975 18980 8732 458.7627 915.5109 915.5025 0.0083 0 20 0.57 1 K.TSTGAPAAIK.K 37013 510.7689 1019.5232 1019.5399 -0.0168 0 43 0.0029 1 K.ANAQAAALYK.V 37030 38120 522.8190 1043.6234 1043.5975 0.0259 1 19 0.62 1 K.TSTGAPAAIKK.L 51371 659.3001 1316.5857 1316.5732 0.0125 0 50 0.00054 1 K.EGNPEEDLTADK.A 52528 451.2208 1350.6405 1350.6204 0.0201 0 31 0.036 1 K.YQEGGVESAFHK.T

91. P09486|SPRC_HUMAN Mass: 35465 Score: 97 Queries matched: 5 emPAI: 0.35 SPARC OS=Homo sapiens GN=SPARC PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 32151 465.7653 929.5161 929.5070 0.0091 1 6 18 2 K.DIDKDLVI.- 46888 608.3175 1214.6204 1214.6118 0.0086 0 39 0.007 1 K.LHLDYIGPCK.Y 17672 54465 710.3908 1418.7670 1418.7518 0.0152 0 58 7.4e-005 1 R.LEAGDHPVELLAR.D 56289 525.9677 1574.8813 1574.8529 0.0284 1 33 0.022 1 K.RLEAGDHPVELLAR.D

92. P13797|PLST_HUMAN Mass: 71279 Score: 95 Queries matched: 13 emPAI: 0.16 Plastin-3 OS=Homo sapiens GN=PLS3 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18958 649.2474 648.2401 648.3265 -0.0864 0 0 1e+002 1 K.LGANM K.K 32801 471.7751 941.5356 941.5334 0.0021 0 14 1.9 1 K.VNKPPYPK.L 41037 545.2459 1088.4772 1088.4557 0.0215 0 24 0.25 1 K.ALENDPDCR.H 41035 41036 42584 560.2478 1118.4810 1118.5430 -0.0620 0 5 18 1 K.EANMPLPGYK.V 17992 617.3368 1232.6591 1232.6765 -0.0174 0 2 1.1e+002 2 K.IGLFADIELSR.N 47705 54198 705.3447 1408.6749 1408.6656 0.0093 0 83 2.3e-007 1 K.LENCNYAVELGK.H 54197 19931 751.8795 1501.7444 1501.7446 -0.0002 0 28 0.07 1 K.MINLSVPDTIDER.A 63639 445.7199 2668.2756 2668.3353 -0.0597 1 4 9 1 R.HVIPMNPNTDDLFKAVGDGIVLCK.M 63642

93. P31146|COR1A_HUMAN Mass: 51678 Score: 95 Queries matched: 8 emPAI: 0.32 Coronin-1A OS=Homo sapiens GN=CORO1A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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2350 418.7355 835.4565 835.4440 0.0125 0 16 1.6 1 R.AVFVSEGK.I 28580 442.2545 882.4944 882.4712 0.0232 0 32 0.032 1 R.HVFGQPAK.A 29252 447.7568 893.4990 893.4971 0.0019 0 10 5 1 K.ILTTGFSR.M 33871 480.7803 959.5459 959.5076 0.0383 0 6 16 6 R.QVALWDTK.H 44421 579.3367 1156.6588 1156.6452 0.0137 0 37 0.011 1 K.LQATVQELQK.R 50115 643.3878 1284.7611 1284.7401 0.0209 1 67 8e-006 1 R.KLQATVQELQK.R 50644 650.3940 1298.7735 1298.5747 0.1987 1 0 41 3 K.ESQRGM GYMPK.R 55685 751.8662 1501.7178 1501.7009 0.0170 0 36 0.01 1 R.AAPEASGTPSSDAVSR.L

94. P52566|GDIR2_HUMAN Mass: 23031 Score: 93 Queries matched: 4 emPAI: 0.36 Rho GDP-dissociation inhibitor 2 OS=Homo sapiens GN=ARHGDIB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3939 428.2549 854.4952 854.4974 -0.0022 0 1 1e+002 1 K.APNVVVTR.L 34211 483.7550 965.4954 965.4719 0.0235 0 42 0.003 1 K.YVQHTYR.T 51143 656.3609 1310.7073 1310.7082 -0.0009 0 53 0.00025 1 K.TLLGDGPVVTDPK.A 51144

95. P01023|A2MG_HUMAN Mass: 164614 Score: 92 Queries matched: 23 emPAI: 0.12 Alpha-2-macroglobulin OS=Homo sapiens GN=A2M PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11673 501.2811 500.2738 500.3071 -0.0333 0 1 1.6e+002 5 K.GGIVR.T 20196 403.7106 805.4066 805.3970 0.0096 0 2 41 3 K.GPTQEFK.K 20194 22195 414.7356 827.4567 827.4501 0.0066 0 26 0.15 1 K.SDIAPVAR.L 22194 28671 442.2840 882.5534 882.5538 -0.0004 0 5 16 3 R.DLKPAIVK.V 28666 7289 445.2373 888.4601 888.4552 0.0049 0 4 92 6 K.SLNEEAVK.K 36413 503.7426 1005.4707 1005.4628 0.0079 0 14 2.5 6 K.FQVDNNNR.L 36417 36795 509.2846 1016.5547 1016.5502 0.0045 1 30 0.065 1 K.SLNEEAVKK.D 14156 542.7610 1083.5075 1083.6077 -0.1002 0 3 26 1 K.GHFSISIPVK.S 42454 558.8044 1115.5943 1115.5975 -0.0032 0 1 39 10 R.QTVSWAVTPK.S 42681 560.8243 1119.6339 1119.6288 0.0051 0 5 16 1 K.SIYKPGQTVK.F 15236 43402 567.7973 1133.5800 1133.5750 0.0050 0 35 0.018 1 R.SASNMAIVDVK.M 18297 628.3268 1254.6390 1254.6357 0.0033 0 25 0.46 1 K.AIGYLNTGYQR.Q 18321 630.3057 1258.5968 1258.5652 0.0316 0 20 1.7 1 R.VGFYESDVMGR.G 48797 49504 636.8343 1271.6540 1271.6656 -0.0116 0 46 0.0013 1 R.VTAAPQSVCALR.A 49505 53829 696.8113 1391.6080 1391.7523 -0.1443 1 0 37 10 K.KLSFYYLIMAK.G 12559 515.9405 1544.7997 1544.7947 0.0050 0 36 0.01 1 R.LVHVEEPHTETVR.K

96. P01009|A1AT_HUMAN Mass: 46878 Score: 92 Queries matched: 18 emPAI: 0.36 Alpha-1-antitrypsin OS=Homo sapiens GN=SERPINA1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24626 426.7564 851.4983 851.4865 0.0118 0 30 0.049 1 R.SASLHLPK.L 28018 439.7517 877.4889 877.4909 -0.0020 1 18 0.9 1 K.FLEDVKK.L 29143 444.7571 887.4997 887.4964 0.0033 0 25 0.21 1 K.AVLTIDEK.G 31633 461.7208 921.4270 921.4192 0.0078 0 7 9.9 5 K.FLENEDR.R 36435 504.7595 1007.5045 1007.4924 0.0121 0 39 0.0064 1 K.QINDYVEK.G 12200 508.3155 1014.6164 1014.6073 0.0091 0 6 36 1 K.SVLGQLGITK.V 36579 36582 36590 12180 12198 40530 539.7768 1077.5391 1077.5203 0.0188 1 17 1.1 1 K.FLENEDRR.S 40526 40528 43550 568.8135 1135.6124 1135.5873 0.0251 1 76 1.3e-006 1 K.KQINDYVEK.G 54455 710.3130 1418.6113 1418.6911 -0.0798 1 3 21 3 K.RLGMFNIQHCK.K 57470 593.9399 1778.7980 1778.7609 0.0372 0 2 22 1 K.TDTSHHDQDHPTFNK.I 57818 917.4661 1832.9177 1832.9156 0.0021 0 1 31 5 K.VFSNGADLSGVTEEAPLK.L

97. O75874|IDHC_HUMAN Mass: 46915 Score: 89 Queries matched: 12 emPAI: 0.17 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens GN=IDH1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20306 404.2259 806.4372 806.4286 0.0085 1 10 6.3 1 K.RVEEFK.L 20256 31377 457.7893 913.5640 913.5596 0.0044 1 9 6.5 6 K.LGENLKIK.L 31355 31368 31376 31378 31381 40978 544.3005 1086.5864 1086.5710 0.0154 0 50 0.00069 1 R.ATDFVVPGPGK.V 40944 52276 671.3462 1340.6778 1340.6684 0.0093 0 65 1.6e-005 1 K.TVEAEAAHGTVTR.H 52273

98. P23528|COF1_HUMAN Mass: 18719 Score: 89 Queries matched: 7 emPAI: 0.21 Cofilin-1 OS=Homo sapiens GN=CFL1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21316 408.2286 814.4426 814.3895 0.0531 0 3 32 1 K.MIYASSK.D 766 36238 502.7855 1003.5564 1003.5186 0.0379 1 6 15 7 K.SSTPEEVKK.R 14816 551.7754 1101.5362 1101.6030 -0.0668 0 5 19 6 M.ASGVAVSDGVIK.V 51978 669.3246 1336.6346 1336.6187 0.0159 0 50 0.00043 1 R.YALYDATYETK.E 51976 51977

99. P00918|CAH2_HUMAN Mass: 29285 Score: 87 Queries matched: 6 emPAI: 0.44 Carbonic anhydrase 2 OS=Homo sapiens GN=CA2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 32469 468.2328 934.4511 934.4509 0.0002 0 19 0.73 1 K.GGPLDGTYR.L 32470 34979 492.7908 983.5671 983.5764 -0.0093 0 52 0.00032 1 K.VGSAKPGLQK.V 34980 45012 585.2656 1168.5167 1168.5149 0.0018 0 39 0.0055 1 K.SADFTNFDPR.G 45014

100. P49913|CAMP_HUMAN Mass: 19517 Score: 84 Queries matched: 9 emPAI: 0.43 Cathelicidin antimicrobial peptide OS=Homo sapiens GN=CAMP PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7071 443.7400 885.4655 885.4668 -0.0013 0 28 0.11 1 R.AIDGINQR.S 7070 7072 7074 31703 463.2252 924.4358 924.4301 0.0058 0 58 6.7e-005 1 R.SSDANLYR.L 31701 31704 9113 54518 711.8889 1421.7632 1421.6868 0.0765 1 0 41 5 K.RCMGTVTLNQAR.G

101. P60900|PSA6_HUMAN Mass: 27838 Score: 83 Queries matched: 2 emPAI: 0.29 Proteasome subunit alpha type-6 OS=Homo sapiens GN=PSMA6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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46996 609.8309 1217.6472 1217.6438 0.0034 1 42 0.0039 1 R.GKDCAVIVTQK.K 50114 643.3672 1284.7198 1284.7150 0.0048 0 62 2.6e-005 1 K.AINQGGLTSVAVR.G

102. Q96PE2|ARHGH_HUMAN Mass: 223645 Score: 83 Queries matched: 110 emPAI: 0.02 Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7280 445.1355 444.1282 444.2696 -0.1414 0 1 80 2 K.AIGGK.K 28791 442.7670 883.5194 883.5127 0.0068 0 27 0.093 1 K.LADILSPR.L 6952 6966 28747 28748 28749 28750 28751 28752 28 32240 466.2664 930.5183 930.5287 -0.0104 0 2 38 10 K.EARPAFLK.F 34696 488.2785 974.5425 974.5107 0.0319 0 0 57 5 R.QEMVIEVK.A 38544 524.2901 1046.5656 1046.5873 -0.0216 1 5 18 9 R.QVFEKIQR.M 39391 531.8155 1061.6163 1061.5539 0.0624 0 4 26 1 R.MLAGSDAIIR.Q 17038 595.8146 1189.6146 1189.6091 0.0055 0 1 40 4 R.SPSFGAGEGLLR.S 50630 650.3894 1298.7642 1298.6215 0.1427 1 0 42 4 R.AEPEEPGATRSR.A 51670 442.5897 1324.7474 1324.6519 0.0955 0 1 32 3 R.TLMQGYMQPLK.Q 55276 492.5808 1474.7205 1474.6630 0.0575 0 3 20 5 R.EAGHFWDPQNFK.S 55273 55279 15347 562.2949 1683.8628 1683.8805 -0.0177 0 0 1.4e+002 1 R.APLSPTGLGQGHTGHVR.F

103. Q14533|KRT81_HUMAN Mass: 56875 Score: 81 Queries matched: 44 emPAI: 0.21 Keratin, type II cuticular Hb1 OS=Homo sapiens GN=KRT81 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20804 406.2152 810.4159 810.4276 -0.0117 0 5 14 1 R.FAAFIDK.V 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.L 30598 30601 30603 30604 30605 30606 30607 30609 30 34502 487.2651 972.5156 972.4876 0.0280 0 13 3.1 1 R.LLEGEEQR.L 34497 10832 10844 10846 10849 10851 10855 10863 34629 487.7674 973.5202 973.5080 0.0122 0 29 0.074 1 R.LTAEVENAK.C 34626 34630 13741 533.7532 1065.4919 1065.5971 -0.1052 1 9 6.4 3 R.FAAFIDKVR.F 47171 611.7706 1221.5266 1221.4932 0.0335 0 54 0.00019 1 R.EAECVEADSGR.L 19180 660.8570 1319.6994 1319.7085 -0.0091 1 3 22 2 R.ATAENEFVALKK.D

Proteins matching the same set of peptides: O43790|KRT86_HUMAN Mass: 55120 Score: 81 Queries matched: 44 Keratin, type II cuticular Hb6 OS=Homo sapiens GN=KRT86 PE=1 SV=1 P78385|KRT83_HUMAN Mass: 55928 Score: 81 Queries matched: 44 Keratin, type II cuticular Hb3 OS=Homo sapiens GN=KRT83 PE=1 SV=2

104. P02786|TFR1_HUMAN Mass: 85274 Score: 79 Queries matched: 9 emPAI: 0.14 Transferrin receptor protein 1 OS=Homo sapiens GN=TFRC PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20193 403.6945 805.3744 805.3719 0.0025 0 13 3.1 1 K.DGFQPSR.S 20383 404.7003 807.3860 807.3875 -0.0015 0 1 42 6 R.DLNQYR.A 35152 493.7767 985.5388 985.5345 0.0043 0 7 13 1 K.LVHANFGTK.K 41441 548.2734 1094.5323 1094.5244 0.0079 0 42 0.0033 1 R.LTTDFGNAEK.T 46396 602.8235 1203.6325 1203.6248 0.0078 0 51 0.00041 1 K.LLNENSYVPR.E 46398 46931 609.2748 1216.5350 1216.5360 -0.0010 0 25 0.17 1 R.EEPGEDFPAAR.R 55175 734.9073 1467.8001 1467.8045 -0.0044 0 35 0.011 1 R.SSGLPNIPVQTISR.A 58101 485.0057 1935.9937 1935.9942 -0.0005 0 1 25 2 K.DFEDLYTPVNGSIVIVR.A

105. P40925|MDHC_HUMAN Mass: 36631 Score: 78 Queries matched: 12 emPAI: 0.22 Malate dehydrogenase, cytoplasmic OS=Homo sapiens GN=MDH1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23185 421.7583 841.5021 841.5385 -0.0364 1 4 20 8 R.AKAQIALK.L 26409 435.7194 869.4242 869.4178 0.0064 0 34 0.019 1 K.AICDHVR.D 31481 458.7638 915.5129 915.5025 0.0104 0 47 0.0013 1 K.LGVTANDVK.N 31475 31476 31477 31478 31527 36440 505.2551 1008.4957 1008.5273 -0.0316 1 0 48 5 R.KLSSAMSAAK.A 45292 589.3487 1176.6829 1176.6503 0.0327 1 1 39 1 K.IFKSQGAALDK.Y 54100 701.4069 1400.7993 1400.7334 0.0660 0 2 23 1 K.DLDVAILVGSM PR.R 57333 876.4127 1750.8108 1750.8777 -0.0670 1 0 34 6 K.EVGVYEALKDDSWLK.G

106. P61769|B2MG_HUMAN Mass: 13820 Score: 77 Queries matched: 11 emPAI: 0.65 Beta-2-microglobulin OS=Homo sapiens GN=B2M PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21207 407.2283 812.4421 812.3123 0.1298 0 2 29 1 K.DEYACR.V 21442 408.7444 815.4742 815.4654 0.0088 1 25 0.25 1 K.IVKWDR.D 3296 423.2503 844.4860 844.4402 0.0458 1 5 64 1 K.NGERIEK.V 3276 24203 42881 561.8159 1121.6172 1121.6193 -0.0021 0 45 0.0019 1 R.VNHVTLSQPK.I 42883 42884 44034 574.7861 1147.5576 1147.5509 0.0067 0 32 0.036 1 K.VEHSDLSFSK.D 44035 55821 506.9354 1517.7843 1517.7726 0.0118 1 26 0.097 1 R.IEKVEHSDLSFSK.D

107. Q3B8N2|LEG9B_HUMAN Mass: 39977 Score: 77 Queries matched: 4 emPAI: 0.20 Galectin-9B OS=Homo sapiens GN=LGALS9B PE=2 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 33282 475.2428 948.4711 948.4665 0.0046 0 40 0.0066 1 R.FDENAVVR.N 35137 493.7757 985.5369 985.4730 0.0639 1 3 28 4 K.GRWGPEER.K 54408 708.8108 1415.6071 1415.6140 -0.0069 0 61 3.2e-005 1 R.FEDGGYVVCNTR.Q 60642 470.6500 2348.2136 2348.2001 0.0135 1 1 19 2 K.VMVNGSLFVQYFHRVPFHR.V

108. Q6DKI2|LEG9C_HUMAN Mass: 40064 Score: 77 Queries matched: 4 emPAI: 0.20 Galectin-9C OS=Homo sapiens GN=LGALS9C PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 32249 466.2699 930.5252 930.4195 0.1057 0 3 36 1 K.GTWGPEER.K 33282 475.2428 948.4711 948.4665 0.0046 0 40 0.0066 1 R.FDENAVVR.N 54408 708.8108 1415.6071 1415.6140 -0.0069 0 61 3.2e-005 1 R.FEDGGYVVCNTR.Q 60642 470.6500 2348.2136 2348.2001 0.0135 1 1 19 2 K.VMVNGSLFVQYFHRVPFHR.V

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109. P02788|TRFL_HUMAN Mass: 80014 Score: 75 Queries matched: 10 emPAI: 0.15 Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24562 426.7162 851.4179 851.4137 0.0041 0 26 0.12 1 K.DSAIGFSR.V 32476 468.2569 934.4992 934.5349 -0.0356 0 24 0.24 1 R.VPSHAVVAR.S 32475 37004 510.7543 1019.4941 1019.5036 -0.0095 0 52 0.00039 1 R.DGAGDVAFIR.E 37007 12262 40047 537.2997 1072.5847 1072.5084 0.0764 1 3 34 6 K.KSCHTAVDR.T 40019 40023 14650 549.3034 1096.5922 1096.4978 0.0944 0 4 72 1 R.YYGYTGAFR.C

110. P05109|S10A8_HUMAN Mass: 10885 Score: 72 Queries matched: 9 emPAI: 0.87 Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24846 427.2487 852.4829 852.3726 0.1103 0 6 12 1 K.SHEESHK.E 4739 432.2390 862.4635 862.4470 0.0166 0 2 2.3e+002 2 -.MLTELEK.A 34062 482.2464 962.4783 962.4722 0.0060 0 43 0.003 1 K.GNFHAVYR.D 34059 34063 3596 424.9106 1271.7099 1271.6874 0.0225 0 10 5 1 K.ALNSIIDVYHK.Y 54475 711.3611 1420.7076 1420.7020 0.0056 0 31 0.032 1 K.LLETECPQYIR.K 54473 54507

111. P37802|TAGL2_HUMAN Mass: 22548 Score: 72 Queries matched: 6 emPAI: 0.60 Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21516 410.7254 819.4363 819.4239 0.0124 0 29 0.083 1 R.GPAYGLSR.E 21518 34863 491.2793 980.5440 980.5152 0.0288 0 12 3.3 1 K.DVGRPQPGR.E 11156 17707 608.3647 1214.7149 1214.6805 0.0344 0 31 0.094 1 R.TLMNLGGLAVAR.D 49780 640.3044 1278.5942 1278.5840 0.0102 0 57 9.2e-005 1 R.NFSDNQLQEGK.N

112. P78386|KRT85_HUMAN Mass: 57306 Score: 72 Queries matched: 38 emPAI: 0.13 Keratin, type II cuticular Hb5 OS=Homo sapiens GN=KRT85 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20804 406.2152 810.4159 810.4276 -0.0117 0 5 14 1 R.FAAFIDK.V 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.L 30598 30601 30603 30604 30605 30606 30607 30609 30 13741 533.7532 1065.4919 1065.5971 -0.1052 1 9 6.4 3 R.FAAFIDKVR.F 47053 610.7846 1219.5547 1219.6448 -0.0901 0 2 37 1 R.ATAENEFVVLK.K 47171 611.7706 1221.5266 1221.4932 0.0335 0 54 0.00019 1 R.EAECVEADSGR.L 50950 654.3994 1306.7842 1306.6564 0.1278 1 4 17 1 R.IAVGGFRAGSCGR.S 19073 50951 50953 50954 54106 702.2979 1402.5811 1402.6259 -0.0448 1 5 12 10 R.SSSFSCGSSRSVR.F

113. Q05639|EF1A2_HUMAN Mass: 50780 Score: 72 Queries matched: 15 emPAI: 0.15 Elongation factor 1-alpha 2 OS=Homo sapiens GN=EEF1A2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17931 616.3624 615.3552 615.3704 -0.0152 1 1 1.7e+002 5 K.LKAER.E 18017 617.3717 616.3644 616.3544 0.0100 1 4 41 2 K.NVEKK.S 29253 447.7570 893.4994 893.4858 0.0136 1 9 6.4 1 R.TIEKFEK.E 29251 31634 461.7391 921.4636 921.4920 -0.0284 1 2 35 2 K.RYDEIVK.E 10924 488.2586 974.5025 974.5437 -0.0411 0 10 26 2 R.LPLQDVYK.I 37215 513.3180 1024.6214 1024.6030 0.0185 0 33 0.022 1 K.IGGIGTVPVGR.V 12409 37205 37207 37213 42655 560.8132 1119.6119 1119.5924 0.0195 0 42 0.0031 1 K.STTTGHLIYK.C 42654 49516 637.2446 1272.4746 1272.5180 -0.0434 0 13 1.8 1 K.MDSTEPAYSEK.R 19127 657.3119 1312.6093 1312.6816 -0.0722 1 0 1.2e+002 1 K.GSFKYAWVLDK.L

114. P19971|TYPH_HUMAN Mass: 50323 Score: 71 Queries matched: 12 emPAI: 0.15 Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20158 402.2167 802.4188 802.4185 0.0003 0 28 0.1 1 R.LSEADIR.G 38544 524.2901 1046.5656 1046.4815 0.0842 0 6 13 4 R.ALCSGSPAER.R 38955 528.3534 1054.6923 1054.5407 0.1516 0 4 15 1 R.GLGHTGGTLDK.L 13292 38954 13320 40890 542.7850 1083.5555 1083.5309 0.0247 0 32 0.033 1 R.DGPALSGPQSR.A 40871 40875 46889 608.3260 1214.6375 1214.6255 0.0120 0 69 7.4e-006 1 R.VAAALDDGSALGR.F 46902 54590 713.4489 1424.8832 1424.7987 0.0845 0 1 25 5 R.LGVGAELLVDVGQR.L

115. P60660|MYL6_HUMAN Mass: 17090 Score: 71 Queries matched: 4 emPAI: 0.50 Myosin light polypeptide 6 OS=Homo sapiens GN=MYL6 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 35688 498.2972 994.5798 994.5811 -0.0014 0 46 0.0014 1 R.HVLVTLGEK.M 11438 11442 52595 677.8701 1353.7257 1353.7252 0.0005 0 51 0.00042 1 R.ALGQNPTNAEVLK.V

116. Q8TF72|SHRM3_HUMAN Mass: 218125 Score: 70 Queries matched: 23 emPAI: 0.02 Protein Shroom3 OS=Homo sapiens GN=SHROOM3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18348 630.3819 629.3747 629.3609 0.0138 1 4 71 2 R.LGERR.R 20158 402.2167 802.4188 802.4548 -0.0361 0 24 0.28 2 R.ISESVLR.D 21594 412.7353 823.4561 823.4552 0.0009 1 10 4.6 7 K.GSYKTLR.L 30833 455.7110 909.4075 909.4933 -0.0858 1 5 16 2 R.AKWAHAAR.E 32355 466.7493 931.4839 931.4723 0.0117 1 43 0.0028 1 R.SSPATADKR.Q 32343 32347 32349 32350 32351 32352 32353 32354 3 11421 498.2961 994.5777 994.4719 0.1058 1 3 58 1 K.RSYSEPEK.M 11423 44085 575.3058 1148.5971 1148.6302 -0.0331 0 9 6.8 1 R.SDVLAGPVHVR.S 44083 44084 49784 640.3299 1278.6453 1278.6680 -0.0227 1 5 14 1 R.KAAPDLGSHLDR.Q 50036 642.3885 1282.7624 1282.6993 0.0631 1 5 12 4 R.RDLELGAPVASR.S

117. P10599|THIO_HUMAN Mass: 12015 Score: 70 Queries matched: 7 emPAI: 0.77 Thioredoxin OS=Homo sapiens GN=TXN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 30724 454.7371 907.4597 907.4399 0.0198 0 42 0.003 1 K.VGEFSGANK.E 2576 420.2318 1257.6736 1257.6816 -0.0080 1 3 86 2 K.EKLEATINELV.-

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51943 668.8316 1335.6487 1335.6306 0.0181 0 48 0.00069 1 K.TAFQEALDAAGDK.L 51952 51955 51958 51961

118. P62805|H4_HUMAN Mass: 11360 Score: 68 Queries matched: 7 emPAI: 1.47 Histone H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11946 504.2792 503.2719 503.2816 -0.0097 1 0 1.1e+002 1 M.SGRGK.G 35460 495.2943 988.5741 988.5706 0.0036 0 26 0.17 1 K.VFLENVIR.D 43390 567.7752 1133.5358 1133.5353 0.0006 0 51 0.00046 1 R.DAVTYTEHAK.R 16841 590.8165 1179.6184 1179.6135 0.0049 0 35 0.016 1 R.ISGLIYEETR.G 51645 442.5607 1324.6604 1324.7463 -0.0859 0 14 1.9 2 R.DNIQGITKPAIR.R 51670 51694 663.8909 1325.7673 1325.6901 0.0772 0 6 9.8 1 K.TVTAMDVVYALK.R

119. O00299|CLIC1_HUMAN Mass: 27248 Score: 66 Queries matched: 5 emPAI: 0.48 Chloride intracellular channel protein 1 OS=Homo sapiens GN=CLIC1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 33525 479.2401 956.4656 956.4715 -0.0060 0 21 0.49 1 R.YLSNAYAR.E 33526 40521 539.7555 1077.4965 1077.5026 -0.0061 0 22 0.34 1 K.IGNCPFSQR.L 51766 664.8214 1327.6282 1327.6368 -0.0086 0 43 0.0024 1 K.NSNPALNDNLEK.G 51765

120. P62937|PPIA_HUMAN Mass: 18229 Score: 64 Queries matched: 5 emPAI: 0.21 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens GN=PPIA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 48296 624.3265 1246.6384 1246.6227 0.0157 1 47 0.0011 1 K.KITIADCGQLE.- 48293 53458 690.3742 1378.7339 1378.7496 -0.0158 1 22 0.3 1 R.VSFELFADKVPK.T 53457 57804 611.3113 1830.9120 1830.9039 0.0081 1 2 23 3 K.SIYGEKFEDENFILK.H

121. P28065|PSB9_HUMAN Mass: 23364 Score: 63 Queries matched: 2 emPAI: 0.16 Proteasome subunit beta type-9 OS=Homo sapiens GN=PSMB9 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10246 477.7835 953.5524 953.4930 0.0594 0 1 35 3 R.AGAPTGDLPR.A 35940 501.2799 1000.5452 1000.5302 0.0150 0 63 2.9e-005 1 R.VSAGEAVVNR.V

122. P15259|PGAM2_HUMAN Mass: 28919 Score: 63 Queries matched: 12 emPAI: 0.45 Phosphoglycerate mutase 2 OS=Homo sapiens GN=PGAM2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 34677 488.2494 974.4843 974.4855 -0.0012 0 46 0.0018 1 K.AMEAVAAQGK.A 34678 10995 39120 530.2756 1058.5366 1058.5509 -0.0143 0 25 0.17 1 R.HYGGLTGLNK.A 39128 41764 552.2461 1102.4776 1102.5804 -0.1028 1 10 6 3 R.KAMEAVAAQGK.A 41748 41761 41766 44153 575.8375 1149.6604 1149.6618 -0.0014 0 34 0.021 1 R.VLIAAHGNSLR.G 44148 17038 595.8146 1189.6146 1189.6125 0.0022 1 2 31 2 K.AMEAVAAQGKAK.-

Proteins matching the same set of peptides: P18669|PGAM1_HUMAN Mass: 28900 Score: 63 Queries matched: 12 Phosphoglycerate mutase 1 OS=Homo sapiens GN=PGAM1 PE=1 SV=2

123. Q9H4G4|GAPR1_HUMAN Mass: 17322 Score: 62 Queries matched: 1 emPAI: 0.22 Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens GN=GLIPR2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 48587 627.3103 1252.6061 1252.6048 0.0014 0 62 3.1e-005 1 K.ASASDGSSFVVAR.Y

124. Q58FF8|H90B2_HUMAN Mass: 44492 Score: 62 Queries matched: 6 emPAI: 0.27 Putative heat shock protein HSP 90-beta 2 OS=Homo sapiens GN=HSP90AB2P PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 36450 505.2662 1008.5179 1008.5062 0.0117 1 17 1 1 K.AKFENLCK.F 44206 576.2901 1150.5656 1150.5506 0.0150 0 28 0.083 1 K.YIDQEELNK.T 44205 1168 412.2204 1233.6394 1233.5724 0.0670 1 0 1.4e+002 1 K.EISDGKAEEEK.G 18160 621.8597 1241.7048 1241.6979 0.0069 0 55 0.00016 1 K.ADLINNLGTIAK.F 12412 513.3088 1536.9046 1536.7282 0.1764 1 0 1.1e+002 2 R.YFSVEEYVSRMK.E

125. P58546|MTPN_HUMAN Mass: 13058 Score: 61 Queries matched: 1 emPAI: 0.30 Myotrophin OS=Homo sapiens GN=MTPN PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 57324 874.4322 1746.8499 1746.8424 0.0075 0 61 2.8e-005 1 K.GPDGLTAFEATDNQAIK.A

126. O75366|AVIL_HUMAN Mass: 92312 Score: 60 Queries matched: 7 emPAI: 0.04 Advillin OS=Homo sapiens GN=AVIL PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24403 425.7481 849.4817 849.4015 0.0802 0 60 6.6e-005 1 K.QGGVASGMK.H 33275 474.7728 947.5310 947.5440 -0.0130 1 6 17 10 K.IAKVFQDK.F 33270 33272 44687 582.2497 1162.4849 1162.6499 -0.1650 1 6 13 1 K.QLFQKWSVK.D 45377 590.2996 1178.5846 1178.6044 -0.0197 1 20 0.54 1 R.KGNAEPDPPVR.L 18996 652.0202 1953.0387 1952.9513 0.0874 1 1 24 1 K.TYEQLKEELGDAAAIMR.I

127. P09327|VILI_HUMAN Mass: 93093 Score: 60 Queries matched: 5 emPAI: 0.04 Villin-1 OS=Homo sapiens GN=VIL1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17773 610.3182 609.3109 609.3347 -0.0238 0 5 36 1 R.AVQHR.E 24403 425.7481 849.4817 849.4378 0.0438 1 60 6.6e-005 1 R.KGGVASGMK.H 4193 428.7751 855.5356 855.3722 0.1633 0 0 52 8 K.HANEEEK.K 5768 434.8732 1301.5977 1301.6472 -0.0495 0 1 40 2 K.LMEVMNHVLGK.R 19513 684.3730 2050.0971 2049.9538 0.1433 1 3 62 1 K.GGVASGMKHVETNSYDVQR.L

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128. P67936|TPM4_HUMAN Mass: 28619 Score: 58 Queries matched: 12 emPAI: 0.28 Tropomyosin alpha-4 chain OS=Homo sapiens GN=TPM4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17603 605.3507 604.3435 604.2816 0.0618 0 1 1.1e+002 5 K.EAETR.A 29246 447.7392 893.4639 893.4606 0.0033 1 16 1.4 1 R.KYEEVAR.K 29245 36646 508.2835 1014.5525 1014.5094 0.0431 0 27 0.13 1 K.AEGDVAALNR.R 36599 42265 555.2547 1108.4948 1108.4819 0.0130 1 2 29 5 K.AADESERGMK.V 42235 42753 561.3041 1120.5937 1120.5876 0.0061 1 8 8.4 5 R.AEFAERTVAK.L 49502 636.8188 1271.6231 1271.6469 -0.0238 1 56 0.00012 1 R.EKAEGDVAALNR.R 52276 671.3462 1340.6778 1340.6459 0.0318 1 18 0.75 2 K.SLEAASEKYSEK.E 53036 683.7992 1365.5838 1365.7027 -0.1189 1 23 0.21 1 K.YEEEIKLLSDK.L 55343 492.8942 1475.6608 1475.6739 -0.0131 1 18 0.81 1 K.LEEAEKAADESER.G

129. P62258|1433E_HUMAN Mass: 29326 Score: 58 Queries matched: 8 emPAI: 0.28 14-3-3 protein epsilon OS=Homo sapiens GN=YWHAE PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 26003 434.2602 866.5058 866.4432 0.0626 1 3 25 4 K.MIREYR.Q 28496 442.2426 882.4707 882.4381 0.0325 1 (2) 30 1 K.M IREYR.Q 30673 454.2644 906.5143 906.5174 -0.0031 0 33 0.033 1 R.NLLSVAYK.N 30674 30676 30679 45998 597.8049 1193.5953 1193.5928 0.0025 0 41 0.0037 1 K.EAAENSLVAYK.A 17110

130. P06703|S10A6_HUMAN Mass: 10230 Score: 58 Queries matched: 8 emPAI: 0.94 Protein S100-A6 OS=Homo sapiens GN=S100A6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7402 446.2204 890.4262 890.4167 0.0095 0 22 1.6 1 R.LMEDLDR.N 31394 458.2535 914.4925 914.4821 0.0104 0 56 0.00017 1 K.LQDAEIAR.L 31392 31396 31401 35907 500.8146 999.6147 999.5964 0.0183 1 26 0.16 2 K.ELKELIQK.E 35904 35906

131. P25311|ZA2G_HUMAN Mass: 34079 Score: 57 Queries matched: 4 emPAI: 0.11 Zinc-alpha-2-glycoprotein OS=Homo sapiens GN=AZGP1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18355 630.3941 629.3869 629.3497 0.0372 0 4 64 1 K.NILDR.Q 43060 564.2861 1126.5575 1126.5618 -0.0043 0 45 0.0016 1 R.AGEVQEPELR.G 43058 15473

132. Q14019|COTL1_HUMAN Mass: 16049 Score: 57 Queries matched: 6 emPAI: 0.91 Coactosin-like protein OS=Homo sapiens GN=COTL1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 397 403.7311 805.4476 805.4446 0.0030 0 36 0.018 1 R.AAYNLVR.D 32450 467.7543 933.4941 933.4920 0.0022 0 34 0.026 1 K.EVVQNFAK.E 32448 32449 34055 481.7802 961.5459 961.5444 0.0015 1 42 0.0041 1 K.TGTDKTLVK.E 35594 497.2677 992.5209 992.5291 -0.0082 1 26 0.15 1 K.EFVISDRK.E

133. P22392|NDKB_HUMAN Mass: 17401 Score: 57 Queries matched: 2 emPAI: 0.49 Nucleoside diphosphate kinase B OS=Homo sapiens GN=NME2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 38776 526.2531 1050.4916 1050.4917 -0.0001 0 48 0.00071 1 R.GDFCIQVGR.N 39844 535.2941 1068.5737 1068.5564 0.0173 0 33 0.028 1 R.NIIHGSDSVK.S

Proteins matching the same set of peptides: O60361|NDK8_HUMAN Mass: 15690 Score: 57 Queries matched: 2 Putative nucleoside diphosphate kinase OS=Homo sapiens GN=NME2P1 PE=5 SV=1

134. P06454|PTMA_HUMAN Mass: 12196 Score: 55 Queries matched: 1 emPAI: 0.32 Prothymosin alpha OS=Homo sapiens GN=PTMA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 56172 783.3143 1564.6141 1564.6376 -0.0235 1 55 9.5e-005 1 R.AAEDDEDDDVDTKK.Q

135. P69905|HBA_HUMAN Mass: 15305 Score: 54 Queries matched: 8 emPAI: 1.48 Hemoglobin subunit alpha OS=Homo sapiens GN=HBA1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 861 409.7224 817.4301 817.4334 -0.0033 0 15 2.1 1 R.VDPVNFK.L 21487 868 39882 536.2819 1070.5492 1070.5471 0.0021 0 25 0.16 1 R.MFLSFPTTK.T 40992 544.3155 1086.6164 1086.6186 -0.0021 1 22 0.4 1 K.LRVDPVNFK.L 40994 45036 586.3380 1170.6615 1170.6608 0.0006 1 38 0.0086 1 M.VLSPADKTNVK.A 55906 510.5866 1528.7379 1528.7270 0.0109 0 33 0.02 1 K.VGAHAGEYGAEALER.M

136. Q08043|ACTN3_HUMAN Mass: 103917 Score: 54 Queries matched: 17 emPAI: 0.04 Alpha-actinin-3 OS=Homo sapiens GN=ACTN3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20231 404.2104 806.4062 806.4286 -0.0224 1 16 1.6 3 R.KLEDFR.D 20221 20224 449 483 24455 425.7761 849.5377 849.4167 0.1210 1 7 12 9 K.WDMVRK.L 24431 24439 51447 660.9114 1319.8083 1319.6470 0.1613 0 3 19 1 K.GLSQEQLNEFR.A 51444 51445 52139 670.3099 1338.6052 1338.5333 0.0719 0 6 11 9 K.QNGMMEPDDFR.A 52129 52131 52132 52141 56011 769.3939 1536.7732 1536.7671 0.0061 0 54 0.00015 1 R.FAIQDISVEETSAK.E

137. P35609|ACTN2_HUMAN Mass: 104358 Score: 54 Queries matched: 16 emPAI: 0.04 Alpha-actinin-2 OS=Homo sapiens GN=ACTN2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20231 404.2104 806.4062 806.4286 -0.0224 1 16 1.6 3 K.KLEDFR.D 20221 20224 449 483 28140 440.7265 879.4385 879.4702 -0.0316 0 7 11 3 K.ALDYIASK.G 28141 28143 28145 28153 39082 529.7100 1057.4054 1057.5040 -0.0986 0 3 26 1 K.ATLPEADGER.Q 48204 622.3848 1242.7550 1242.6357 0.1193 0 1 31 3 R.HRPDLIDYSK.L 55462 744.3875 1486.7604 1486.7317 0.0287 0 2 29 3 R.NVNIQNFHTSWK.D 55458 56011 769.3939 1536.7732 1536.7671 0.0061 0 54 0.00015 1 R.FAIQDISVEETSAK.E

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67050 530.6309 3177.7419 3177.5764 0.1655 1 1 7.8 1 R.SSIQITGALEDQMNQLKQYEHNIINYK.N

138. P01034|CYTC_HUMAN Mass: 16017 Score: 54 Queries matched: 5 emPAI: 0.55 Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 40670 540.7356 1079.4567 1079.4454 0.0112 0 51 0.00039 1 K.ASNDMYHSR.A 17859 613.8044 1225.5943 1225.5979 -0.0036 0 22 0.34 1 R.ALDFAVGEYNK.A 17860 17862 57633 600.9731 1799.8974 1799.8836 0.0139 1 6 9.4 1 R.LVGGPMDASVEEEGVRR.A

139. O00391|QSOX1_HUMAN Mass: 83324 Score: 54 Queries matched: 9 emPAI: 0.09 Sulfhydryl oxidase 1 OS=Homo sapiens GN=QSOX1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18799 646.3486 645.3413 645.3810 -0.0396 0 0 1.6e+002 1 R.LSGLTR.E 21288 407.7442 813.4738 813.4749 -0.0010 0 1 44 1 K.IAPTVWK.L 32148 465.7607 929.5068 929.5004 0.0064 0 6 16 1 R.VPVLMESR.S 42434 557.8165 1113.6184 1113.6142 0.0042 0 37 0.012 1 R.VLNTEANVVR.K 42435 17168 598.8569 1195.6991 1195.5873 0.1118 0 3 22 9 K.LEEIDGFFAR.N 49472 635.7801 1269.5457 1269.7153 -0.1696 1 1 32 1 R.RVLNTEANVVR.K 52703 678.8416 1355.6686 1355.6721 -0.0035 0 42 0.0032 1 R.LAGAPSEDPQFPK.V 52704

140. Q5VSK2|MRC1L_HUMAN Mass: 168904 Score: 52 Queries matched: 14 emPAI: 0.04 Macrophage mannose receptor 1-like protein 1 OS=Homo sapiens GN=MRC1L1 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2342 418.7001 835.3857 835.3858 -0.0001 0 10 5.6 1 R.DALTTCR.K 3170 422.2097 842.4048 842.3956 0.0092 0 2 1.3e+002 8 K.SSYSLMR.Q 29430 449.2158 896.4171 896.4174 -0.0003 0 11 3.8 2 R.GYICQTR.S 32279 466.2753 930.5360 930.4671 0.0689 1 3 32 2 K.NWQEARK.A 10407 481.2395 960.4644 960.4699 -0.0054 0 10 12 1 K.SCVSLNPGK.N 34160 482.7557 963.4969 963.4808 0.0161 1 12 3.3 1 R.DALTTCRK.E 39839 535.2791 1068.5437 1068.5465 -0.0028 0 8 7.5 1 K.SALTWHQAR.K 40358 538.7952 1075.5759 1075.5662 0.0097 0 34 0.02 1 R.LITASGSYHK.L 40357 46032 597.8521 1193.6896 1193.5353 0.1544 0 3 23 1 R.YTNWAADEPK.L 46027 46051 46863 607.8256 1213.6366 1213.6190 0.0175 0 36 0.014 1 R.SQGPEIVEVEK.G 58368 499.8209 1995.2547 1995.0677 0.1870 1 0 6 1 R.NDAQSAYFIGLLISLDKK.F

Proteins matching the same set of peptides: P22897|MRC1_HUMAN Mass: 168870 Score: 52 Queries matched: 14 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1

141. Q5T749|KPRP_HUMAN Mass: 67172 Score: 52 Queries matched: 38 emPAI: 0.11 Keratinocyte proline-rich protein OS=Homo sapiens GN=KPRP PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9241 465.2556 928.4967 928.5607 -0.0640 1 12 6.7 1 R.RLQLFPR.S 9245 9250 34176 483.2342 964.4539 964.4614 -0.0075 0 (15) 2 1 R.SEPIYNSR.C 34179 34180 34182 34183 34186 34187 34188 34189 34 38538 524.2825 1046.5505 1046.5444 0.0062 0 16 1.4 1 R.CPPPAPRPR.L 41150 545.7804 1089.5462 1089.5349 0.0113 0 15 2 1 R.RPISSCSQR.R 41151 15250 561.2880 1120.5615 1120.5625 -0.0010 1 23 1.1 1 R.RSEPIYNSR.C 42735 42737 42739 42744 42745 46983 609.7935 1217.5724 1217.5533 0.0192 0 35 0.02 1 R.IEISSPCCPR.Q 46982 47376 613.3143 1224.6140 1224.6146 -0.0006 0 28 0.076 1 R.GRPAVCQPQGR.F 829 47375 47377 47378 47379 47380 47381 47382 4 55664 500.2566 1497.7480 1497.7358 0.0122 1 6 9.4 1 R.RLDQCPESPLQR.C

142. P35241|RADI_HUMAN Mass: 68635 Score: 51 Queries matched: 22 emPAI: 0.11 Radixin OS=Homo sapiens GN=RDX PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20252 404.2151 806.4156 806.3592 0.0563 0 9 7.2 1 K.QAADQM K.N 2161 416.3030 830.5914 830.4359 0.1556 1 18 5.9 5 R.QGNTKQR.I 2139 2155 22351 2167 2183 2192 2197 2198 22366 2206 29254 447.7736 893.5325 893.5375 -0.0049 0 8 8.4 1 R.LFFLQVK.E 34196 483.2583 964.5021 964.4978 0.0043 1 10 5.7 1 R.NISFNDKK.F 34198 36166 502.2830 1002.5514 1002.4981 0.0532 1 3 29 3 K.EEAERLEK.E 39466 532.2642 1062.5138 1062.5015 0.0123 1 23 0.29 1 R.EKEELMER.L 14260 544.3018 1086.5890 1086.6801 -0.0911 1 17 3.7 1 K.FVIKPIDKK.A 41015 544.7869 1087.5592 1087.5873 -0.0280 1 1 54 5 R.AAEEAKSAIAK.Q 16869 591.8020 1181.5894 1181.5869 0.0024 0 25 0.16 1 K.APDFVFYAPR.L 47546 616.3070 1230.5994 1230.6204 -0.0210 1 47 0.0012 1 K.AQKELEEQTR.K

143. P26447|S10A4_HUMAN Mass: 11949 Score: 51 Queries matched: 8 emPAI: 0.77 Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22337 416.2552 830.4959 830.4861 0.0098 1 17 1.4 1 K.LNKSELK.E 24309 424.6958 847.3770 847.3932 -0.0162 0 4 29 6 -.MACPLEK.A 7366 445.7537 889.4929 889.4909 0.0020 0 21 0.47 1 R.ELPSFLGK.R 7367 38524 523.8071 1045.5997 1045.5920 0.0077 1 13 3.1 1 R.ELPSFLGKR.T 39679 533.2671 1064.5195 1064.5251 -0.0055 1 43 0.0025 1 K.RTDEAAFQK.L 14318 544.8232 1087.6319 1087.6237 0.0082 1 37 0.013 1 K.SELKELLTR.E 14317

144. Q06830|PRDX1_HUMAN Mass: 22324 Score: 50 Queries matched: 13 emPAI: 0.37 Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21508 410.2222 818.4299 818.4134 0.0165 0 20 0.61 1 R.SVDETLR.L 21501 21504 21506 7206 444.7632 887.5119 887.4389 0.0731 1 1 53 10 K.SKEYFSK.Q 34850 490.7729 979.5313 979.5239 0.0074 0 24 0.22 1 K.IGHPAPNFK.A 34849 11118 42128 554.3103 1106.6060 1106.5972 0.0088 0 46 0.0015 1 R.TIAQDYGVLK.A 42122 42125 46187 598.8293 1195.6441 1195.6237 0.0203 0 26 0.13 1 R.LVQAFQFTDK.H 19471 680.3812 1358.7479 1358.7922 -0.0443 1 4 51 1 R.GLFIIDDKGILR.Q

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145. P00491|PNPH_HUMAN Mass: 32325 Score: 50 Queries matched: 3 emPAI: 0.12 Purine nucleoside phosphorylase OS=Homo sapiens GN=NP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 43666 569.7929 1137.5713 1137.5778 -0.0065 0 50 0.00048 1 K.ANHEEVLAAGK.Q 43667 44638 581.8235 1161.6325 1161.5163 0.1162 1 2 37 1 R.GPNDERFGDR.F

146. Q58FF7|H90B3_HUMAN Mass: 68624 Score: 49 Queries matched: 12 emPAI: 0.05 Putative heat shock protein HSP 90-beta-3 OS=Homo sapiens GN=HSP90AB3P PE=5 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 292 402.2327 802.4508 802.4701 -0.0193 0 11 24 1 R.ALLFSPR.R 25555 432.2213 862.4279 862.4218 0.0061 0 3 36 3 R.EMLQQSK.I 38234 523.2900 1044.5654 1044.5927 -0.0273 1 9 7.7 4 K.VEKVTISNR.L 38188 38190 38232 38279 38334 38341 48333 625.3148 1248.6149 1248.6098 0.0051 0 49 0.00066 1 K.EQVANSAFVER.V 53829 696.8113 1391.6080 1391.5883 0.0197 1 (1) 33 6 R.DNSTMGYMMAKK.H 9209 464.9341 1391.7804 1391.5883 0.1921 1 1 31 3 R.DNSTMGYMMAKK.H

147. P09960|LKHA4_HUMAN Mass: 69868 Score: 48 Queries matched: 8 emPAI: 0.11 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 29405 448.7659 895.5172 895.4916 0.0256 1 1 38 3 R.LFGEKFR.H 33109 473.2905 944.5664 944.5807 -0.0143 0 14 2.9 1 R.APLPLGHIK.R 35079 493.2848 984.5550 984.5604 -0.0054 0 14 2 1 K.VVINGQEVK.Y 40744 541.7564 1081.4983 1081.5120 -0.0137 0 9 6.5 3 K.DFLYSYFK.D 40740 43389 567.7743 1133.5341 1133.5757 -0.0416 1 0 53 4 K.AYVEKFSYK.S 44741 582.7899 1163.5652 1163.5611 0.0041 0 28 0.073 1 K.TFGETHPFTK.L 51768 664.8485 1327.6825 1327.6806 0.0019 0 44 0.0018 1 R.AILPCQDTPSVK.L

148. O75083|WDR1_HUMAN Mass: 66836 Score: 48 Queries matched: 12 emPAI: 0.18 WD repeat-containing protein 1 OS=Homo sapiens GN=WDR1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20066 400.7392 799.4639 799.4552 0.0087 0 31 0.048 1 R.IAVVGEGR.E 20068 123 28596 442.2589 882.5032 882.4633 0.0399 0 (1) 34 1 R.YTSLMLR.D 29111 444.2600 886.5055 886.5124 -0.0069 0 23 0.39 1 K.VINSVDIK.Q 30070 450.2753 898.5360 898.4582 0.0778 0 8 7.5 1 R.YTSLMLR.D 29976 32344 466.7435 931.4725 931.4512 0.0213 0 19 0.71 1 K.FTIGDHSR.F 33354 476.7495 951.4845 951.4662 0.0183 0 31 0.044 1 R.DYSGQGVVK.L 41693 551.7671 1101.5195 1101.5131 0.0065 0 31 0.05 1 K.YEYQPFAGK.I 43898 573.3212 1144.6278 1144.6241 0.0038 0 18 0.9 1 K.VFASLPQVER.G 50855 653.3190 1304.6234 1304.6612 -0.0378 1 8 8.2 7 K.IKDIAWTEDSK.R

149. P31944|CASPE_HUMAN Mass: 27947 Score: 48 Queries matched: 8 emPAI: 0.14 Caspase-14 OS=Homo sapiens GN=CASP14 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 798 408.2430 814.4715 814.3279 0.1435 0 3 73 1 K.YDMSGAR.L 21304 34159 482.7545 963.4945 963.4774 0.0172 0 29 0.065 1 K.FQQAIDSR.E 44360 578.2940 1154.5734 1154.5754 -0.0019 1 3 24 8 R.QLRFESTMK.R 44451 579.8196 1157.6247 1157.6040 0.0207 0 33 0.03 1 K.TNPEIQSTLR.K 16247 44449 44450

150. P08123|CO1A2_HUMAN Mass: 129723 Score: 48 Queries matched: 21 emPAI: 0.09 Collagen alpha-2(I) chain OS=Homo sapiens GN=COL1A2 PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22785 420.7409 839.4673 839.4614 0.0059 0 24 0.22 1 R.GVVGPQGAR.G 24565 426.7401 851.4655 851.4613 0.0042 0 29 0.067 1 R.VGAPGPAGAR.G 32948 472.7153 943.4160 943.4546 -0.0386 0 3 36 4 R.AGVM GPPGSR.G 34969 492.7503 983.4861 983.4746 0.0115 0 5 15 7 -.MLSFVDTR.T 13046 521.3568 1040.6990 1040.5614 0.1375 1 1 98 1 R.GAAGIPGGKGEK.G 39707 533.2795 1064.5444 1064.5839 -0.0396 1 2 33 6 R.GRVGAPGPAGAR.G 41444 548.2875 1094.5604 1094.5581 0.0023 1 18 0.68 1 R.GPRGDQGPVGR.T 45018 585.3626 1168.7106 1168.5877 0.1229 0 9 5.8 4 R.GEPGNIGFPGPK.G 16485 47250 612.3132 1222.6119 1222.6055 0.0064 1 46 0.0013 1 R.GPAGPSGPAGKDGR.T 47840 618.2909 1234.5673 1234.6054 -0.0381 0 12 2.8 1 R.GEAGAAGPAGPAGPR.G 47796 50004 642.3793 1282.7441 1282.6378 0.1063 1 0 39 5 R.GSPGSRGLPGADGR.A 62947 437.2256 2617.3101 2617.2633 0.0467 1 4 7.9 1 R.GSPGERGEVGPAGPNGFAGPAGAAGQPGAK.G 62949 62950 62951 62953 63066 439.5994 2631.5524 2631.3976 0.1549 0 3 2.7 1 R.TLLLLAVTLCLATCQSLQEETVR.K 64422 458.7568 2746.4968 2746.4991 -0.0023 1 1 12 1 K.GAAGLPGVAGAPGLPGPRGIPGPVGAAGATGAR.G 64817 469.7252 2812.3075 2812.4468 -0.1393 1 1 13 2 K.GEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGK.G

151. Q9NZK5|CECR1_HUMAN Mass: 59180 Score: 47 Queries matched: 4 emPAI: 0.13 Adenosine deaminase CECR1 OS=Homo sapiens GN=CECR1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 32097 465.2698 928.5251 928.5130 0.0121 0 34 0.024 1 R.IGHGFALSK.H 34210 483.7546 965.4947 965.4818 0.0129 0 13 2.2 1 K.TYQEVAQK.F 50170 644.3698 1286.7250 1286.7194 0.0056 1 34 0.019 1 R.SKDVAVIAESIR.M 50141

152. P05090|APOD_HUMAN Mass: 21547 Score: 47 Queries matched: 11 emPAI: 0.39 Apolipoprotein D OS=Homo sapiens GN=APOD PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 27574 436.2588 870.5030 870.4923 0.0107 0 19 0.77 1 K.VLNQELR.A 27563 27575 27587 37758 517.7737 1033.5329 1033.5193 0.0136 0 23 0.27 1 K.IPTTFENGR.C 50275 646.7890 1291.5634 1291.5901 -0.0267 0 (4) 17 1 K.MTVTDQVNCPK.L 50961 654.8039 1307.5931 1307.5850 0.0082 0 43 0.0023 1 K.MTVTDQVNCPK.L 6317 6318 50967 50970

153. P14136|GFAP_HUMAN Mass: 49907 Score: 47 Queries matched: 43 emPAI: 0.07

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Glial fibrillary acidic protein OS=Homo sapiens GN=GFAP PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15906 572.3539 571.3466 571.3693 -0.0227 0 3 43 4 R.NIVVK.T 17278 600.4642 599.4569 599.3391 0.1178 0 2 36 1 R.LGPGTR.L 17275 18780 645.3504 644.3431 644.3493 -0.0062 0 0 1.6e+002 1 R.LDLER.K 30624 453.7452 905.4758 905.4607 0.0152 0 37 0.014 1 R.FLEQQNK.A 30598 30601 30603 30604 30605 30606 30607 30609 3 35132 493.7755 985.5365 985.5192 0.0173 0 3 33 1 R.ELQEQLAR.Q 14257 544.3011 1086.5876 1086.5669 0.0207 1 3 87 1 R.KLLEGEENR.I 41748 552.2359 1102.4573 1102.5254 -0.0681 0 7 11 5 R.QEADEATLAR.L 41749 41760 41764 279 402.2169 1203.6290 1203.6645 -0.0355 1 7 68 1 R.NIVVKTVEMR.D 47546 616.3070 1230.5994 1230.5741 0.0253 1 4 20 6 R.QAKHEANDYR.R 9530 469.3287 1404.9642 1404.7976 0.1666 1 1 54 2 K.LALDIEIATYRK.L 56150 781.9254 1561.8363 1561.7770 0.0594 0 1 30 4 R.QLQSLTCDLESLR.G 57586 898.4121 1794.8095 1794.9264 -0.1169 1 2 19 5 R.VDFSLAGALNAGFKETR.A

154. P23381|SYWC_HUMAN Mass: 53474 Score: 47 Queries matched: 15 emPAI: 0.07 Tryptophanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=WARS PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21733 412.7601 823.5056 823.3712 0.1344 0 1 38 5 K.AAAGEDYK.A 25583 432.2665 862.5184 862.4450 0.0735 0 4 24 5 R.GIFFSHR.D 4781 4784 4788 27973 438.2611 874.5075 874.4872 0.0204 1 6 17 4 R.SLKAGNASK.D 6447 6452 27965 32368 466.7653 931.5160 931.4862 0.0298 0 17 1.1 2 K.EVTDEIVK.E 32363 32366 34473 486.7712 971.5278 971.5189 0.0089 0 16 1.7 1 K.HVTFNQVK.G 46272 600.3765 1198.7385 1198.6454 0.0931 1 0 45 5 K.MLVSLKMSYK.A 54118 702.8578 1403.7009 1403.6892 0.0117 1 47 0.00094 1 K.AGNASKDEIDSAVK.M

155. P16035|TIMP2_HUMAN Mass: 25067 Score: 47 Queries matched: 1 emPAI: 0.15 Metalloproteinase inhibitor 2 OS=Homo sapiens GN=TIMP2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 56597 813.9059 1625.7973 1625.7937 0.0036 1 47 0.00083 1 R.GAAPPKQEFLDIEDP.-

156. P78417|GSTO1_HUMAN Mass: 27833 Score: 46 Queries matched: 14 emPAI: 0.14 Glutathione S-transferase omega-1 OS=Homo sapiens GN=GSTO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17613 606.3024 605.2951 605.2769 0.0182 0 5 21 1 M.SGESAR.S 9120 463.7104 925.4063 925.4116 -0.0053 0 4 19 2 R.FCPFAER.T 40558 540.3068 1078.5991 1078.6135 -0.0144 0 22 0.34 1 R.HEVININLK.N 41040 545.2719 1088.5293 1088.5390 -0.0097 0 14 2.3 1 K.LLPDDPYEK.A 42873 561.7760 1121.5375 1121.5499 -0.0124 1 4 23 8 -.MSGESARSLGK.G 42859 46837 606.7823 1211.5501 1211.5605 -0.0104 0 46 0.001 1 K.LNECVDHTPK.L 51433 660.8406 1319.6667 1319.6834 -0.0167 0 28 0.078 1 K.GSAPPGPVPEGSIR.I 51434 51436 19180 9482 469.2889 1404.8448 1404.8201 0.0247 1 8 20 1 K.GIRHEVININLK.N 9485 9486

157. P55072|TERA_HUMAN Mass: 89950 Score: 46 Queries matched: 117 emPAI: 0.04 Transitional endoplasmic reticulum ATPase OS=Homo sapiens GN=VCP PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21499 410.2095 818.4045 818.4650 -0.0606 0 1 49 3 K.GDIFLVR.G 27263 435.7744 869.5341 869.5195 0.0146 1 9 5.4 3 R.VVRNNLR.V 26427 26455 26466 26487 26498 26510 26517 26571 265 30492 453.2258 904.4371 904.4250 0.0121 0 29 0.088 1 R.SVSDNDIR.K 33331 476.2439 950.4733 950.4709 0.0025 1 15 1.7 1 R.KAFEEAEK.N 34036 481.7498 961.4850 961.4716 0.0134 0 8 9.2 6 R.ESIESEIR.R 34040 34943 492.2405 982.4663 982.4944 -0.0281 1 3 28 9 K.THGEVERR.I 35611 994.4584 993.4511 993.5066 -0.0555 1 6 24 1 R.GGMRAVEFK.V 35610 13234 526.2709 1050.5273 1050.5168 0.0105 0 (5) 34 1 K.MDELQLFR.G 13783 534.3103 1066.6061 1066.5117 0.0944 0 5 42 2 K.MDELQLFR.G 13793 40291 538.2698 1074.5250 1074.5305 -0.0055 0 17 1.1 1 K.LAGESESNLR.K 42453 558.7636 1115.5126 1115.4956 0.0170 0 46 0.0014 1 R.GGNIGDGGGAADR.V

158. P09382|LEG1_HUMAN Mass: 15048 Score: 46 Queries matched: 6 emPAI: 0.99 Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 38011 521.2945 1040.5745 1040.5614 0.0131 1 35 0.014 1 R.VRGEVAPDAK.S 38005 40349 538.7433 1075.4721 1075.4683 0.0039 0 39 0.0065 1 K.DGGAWGTEQR.E 55425 496.2393 1485.6960 1485.6783 0.0177 0 16 1.1 1 K.DSNNLCLHFNPR.F 55424 14672 549.9292 1646.7658 1646.7471 0.0187 0 24 0.19 1 R.FNAHGDANTIVCNSK.D

159. Q01518|CAP1_HUMAN Mass: 52222 Score: 45 Queries matched: 11 emPAI: 0.07 Adenylyl cyclase-associated protein 1 OS=Homo sapiens GN=CAP1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3256 423.2009 844.3872 844.4290 -0.0418 0 5 64 1 K.EIGGDVQK.H 8401 454.7355 907.4564 907.5239 -0.0675 1 2 36 1 K.THKNPALK.A 41223 546.2618 1090.5091 1090.5077 0.0015 0 2 37 3 M.ADM QNLVER.L 16588 587.3187 1172.6229 1172.6401 -0.0172 1 3 90 2 K.ISKEIGGDVQK.H 46838 606.8539 1211.6933 1211.6761 0.0172 1 8 7.9 1 K.KEPAVLELEGK.K 47844 618.3109 1234.6073 1234.5863 0.0210 0 45 0.0014 1 K.NSLDCEIVSAK.S 1540 413.2371 1236.6896 1236.6938 -0.0042 1 5 37 1 K.NPALKAQSGPVR.S 1555 56482 401.9975 1603.9609 1603.7810 0.1799 1 (1) 26 2 -.MADMQNLVERLER.A 56559 540.8746 1619.6021 1619.7759 -0.1739 1 5 6 5 -.MADMQNLVERLER.A 56565 540.9969 1619.9688 1619.7759 0.1929 1 (0) 27 1 -.MADM QNLVERLER.A

160. Q96QA5|GSDMA_HUMAN Mass: 49633 Score: 45 Queries matched: 5 emPAI: 0.08 Gasdermin-A OS=Homo sapiens GN=GSDMA PE=2 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 32555 469.7580 937.5015 937.6324 -0.1309 1 6 11 9 K.KILPVQLK.L 33790 480.2666 958.5187 958.5083 0.0103 0 51 0.00054 1 K.ALETLQER.K 33767 33772

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39707 533.2795 1064.5444 1064.5767 -0.0323 1 2 35 8 R.KSTLFWGAR.Y

161. O15511|ARPC5_HUMAN Mass: 16367 Score: 45 Queries matched: 1 emPAI: 0.24 Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens GN=ARPC5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13824 535.8184 1069.6223 1069.6244 -0.0021 0 45 0.0017 1 K.ALAAGGVGSIVR.V

162. Q9H4B7|TBB1_HUMAN Mass: 50865 Score: 44 Queries matched: 7 emPAI: 0.07 Tubulin beta-1 chain OS=Homo sapiens GN=TUBB1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20412 404.7347 807.4549 807.3399 0.1151 0 1 42 4 R.EEYPDR.I 13793 534.3221 1066.6296 1066.4536 0.1761 0 14 5.6 1 R.NTMAACDLR.R 13783 13795 40445 539.2822 1076.5499 1076.5250 0.0249 1 18 0.94 1 K.IREEYPDR.I 43775 572.3251 1142.6355 1142.6270 0.0085 0 44 0.002 1 K.LAVNMVPFPR.L 46569 604.3113 1206.6081 1206.5597 0.0484 1 3 24 4 R.NTMAACDLRR.G

163. P07339|CATD_HUMAN Mass: 45037 Score: 44 Queries matched: 7 emPAI: 0.08 Cathepsin D OS=Homo sapiens GN=CTSD PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21517 410.7280 819.4415 819.4239 0.0176 0 39 0.0089 1 R.VGFAEAAR.L 21519 32396 467.2634 932.5122 932.5080 0.0043 1 15 2 1 R.VGFAEAARL.- 38121 523.2438 1044.4730 1044.5968 -0.1237 0 10 6 3 K.QPGITFIAAK.F 13713 533.2910 1064.5675 1064.5390 0.0286 0 20 2.3 1 K.LSPEDYTLK.V 46766 606.3648 1210.7150 1210.7186 -0.0036 1 2 28 2 R.IPLHKFTSIR.R 46789

164. P11021|GRP78_HUMAN Mass: 72402 Score: 43 Queries matched: 5 emPAI: 0.11 78 kDa glucose-regulated protein OS=Homo sapiens GN=HSPA5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7107 443.7709 885.5272 885.5284 -0.0011 1 15 2.1 1 R.NTVVPTKK.S 35098 493.7635 985.5124 985.5080 0.0044 0 17 1.1 1 R.LTPEEIER.M 37668 517.2723 1032.5300 1032.5451 -0.0151 1 2 36 9 K.LGGKLSSEDK.E 45836 596.3205 1190.6265 1190.6295 -0.0030 0 28 0.082 1 K.VYEGERPLTK.D 47494 614.8212 1227.6279 1227.6207 0.0072 0 39 0.0075 1 R.VEIIANDQGNR.I

165. Q15648|MED1_HUMAN Mass: 169342 Score: 41 Queries matched: 82 emPAI: 0.02 Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens GN=MED1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 29067 443.7670 885.5195 885.4556 0.0639 0 3 31 1 K.ATNAGPLDK.I 29014 29030 29079 29081 32407 467.2700 932.5255 932.4563 0.0692 1 2 40 3 R.TPSNDGKSK.D 32400 32405 11713 501.7911 1001.5676 1001.5692 -0.0015 1 11 5.6 4 K.LVRQVMEK.R 39876 536.2480 1070.4815 1070.6335 -0.1520 0 1 48 4 K.KPSLTAVIDK.L 41143 545.7771 1089.5397 1089.5488 -0.0091 0 (9) 7.6 2 K.VTSLPAMTDR.L 41127 41128 14359 41129 41130 41131 14360 41133 41959 553.7641 1105.5137 1105.5438 -0.0301 0 17 1.3 3 K.VTSLPAMTDR.L 41958 41960 41964 41967 41968 41970 41971 41972 42118 554.2835 1106.5525 1106.4727 0.0798 0 35 0.019 3 K.AQGETEESEK.L 42081 42083 42085 42088 42089 42090 42091 42092 47791 618.2521 1234.4896 1234.5677 -0.0780 1 5 14 3 M.KAQGETEESEK.L 12303 511.3205 1530.9396 1530.7638 0.1758 0 2 64 1 K.NSSQSGGKPGSSPITK.H

166. P01876|IGHA1_HUMAN Mass: 38486 Score: 40 Queries matched: 7 emPAI: 0.32 Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17306 601.3483 600.3411 600.3595 -0.0184 0 0 67 1 K.DVLVR.W 21488 409.7596 817.5046 817.3970 0.1076 0 3 35 2 R.VAAEDWK.K 32276 466.2747 930.5347 930.5386 -0.0038 0 24 0.28 1 K.TPLTATLSK.S 32245 32589 470.7458 939.4771 939.4774 -0.0003 0 26 0.12 1 K.SAVQGPPER.D 32590 53374 688.3178 1374.6210 1374.6126 0.0084 0 39 0.006 1 K.TFTCTAAYPESK.T

167. P00558|PGK1_HUMAN Mass: 44985 Score: 40 Queries matched: 10 emPAI: 0.17 Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20531 405.2179 808.4212 808.4079 0.0134 0 37 0.012 1 K.YAEAVTR.A 20510 28707 442.7403 883.4660 883.4439 0.0220 0 14 2.1 1 K.ELNYFAK.A 28816 34624 487.7437 973.4728 973.4505 0.0223 0 22 0.39 1 R.FHVEEEGK.G 37554 516.7445 1031.4745 1031.4594 0.0151 0 28 0.091 1 K.DCVGPEVEK.A 44463 580.2995 1158.5845 1158.5669 0.0176 1 25 0.17 1 R.FHVEEEGKGK.D 48389 625.3618 1248.7091 1248.6747 0.0343 1 5 17 1 -.MSLSNKLTLDK.L 48410 14282 544.3329 1629.9768 1629.8760 0.1008 1 2 1e+002 1 K.VADKIQLINNMLDK.V

168. Q96K76|UBP47_HUMAN Mass: 158538 Score: 39 Queries matched: 63 emPAI: 0.02 Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens GN=USP47 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3306 423.2762 844.5379 844.3788 0.1592 0 4 82 1 K.THGGSSGSR.G 24189 29313 448.2268 894.4391 894.3939 0.0452 0 6 12 1 K.QVMMENK.L 29278 29292 29314 30484 452.7448 903.4750 903.4185 0.0565 0 9 7.8 8 R.ELEEQEK.R 31629 461.2818 920.5491 920.4426 0.1066 0 11 4.8 1 R.WKPSEMK.L 31610 31626 31628 31630 34629 487.7674 973.5202 973.5444 -0.0242 1 2 38 4 R.ITQEDIKK.T 37130 512.2846 1022.5547 1022.5801 -0.0253 0 6 15 8 K.FLLDAVFAK.G 44297 576.7870 1151.5595 1151.5645 -0.0050 1 38 0.0075 1 R.QNIFDEMKK.K 16151 44289 44290 44291 44292 44293 44294 44295 4 44609 581.3571 1160.6996 1160.6149 0.0847 1 2 37 3 K.RAIETTDVTR.S 49011 632.2734 1262.5322 1262.6765 -0.1443 1 10 4.4 2 K.SMSQLAVLSRR.W 48995 52194 670.8357 1339.6568 1339.7459 -0.0891 1 19 0.54 2 R.QSKEELIPQLR.E 52190 52191 52192 52193 52195 52197 52198 5219 53800 464.5700 1390.6881 1390.7126 -0.0245 0 3 21 3 R.VLCIIQDTTNSK.T

169. P28066|PSA5_HUMAN Mass: 26565 Score: 39 Queries matched: 1 emPAI: 0.14

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Proteasome subunit alpha type-5 OS=Homo sapiens GN=PSMA5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 39460 532.2600 1062.5054 1062.5094 -0.0040 0 39 0.007 1 R.GVNTFSPEGR.L

170. P61916|NPC2_HUMAN Mass: 16902 Score: 39 Queries matched: 5 emPAI: 0.23 Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21559 412.2108 822.4070 822.4123 -0.0053 0 5 16 1 K.SEYPSIK.L 21558 7205 444.7605 887.5065 887.4389 0.0676 0 1 50 1 K.TYSYLNK.L 36684 508.7546 1015.4947 1015.5121 -0.0174 0 34 0.027 1 K.SGINCPIQK.D 36685

171. P15153|RAC2_HUMAN Mass: 21814 Score: 39 Queries matched: 4 emPAI: 0.18 Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens GN=RAC2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17617 606.3301 605.3228 605.3207 0.0021 0 1 53 1 -.M QAIK.C 37965 521.2752 1040.5359 1040.5437 -0.0078 0 12 3.1 1 R.AVLCPQPTR.Q 48136 620.8066 1239.5986 1239.5918 0.0069 0 39 0.006 1 K.YLECSALTQR.G 54588 713.4476 1424.8807 1424.7558 0.1249 1 1 23 5 R.AVLCPQPTRQQK.R

172. P60763|RAC3_HUMAN Mass: 21764 Score: 39 Queries matched: 4 emPAI: 0.18 Ras-related C3 botulinum toxin substrate 3 OS=Homo sapiens GN=RAC3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17617 606.3301 605.3228 605.3207 0.0021 0 1 53 1 -.MQAIK.C 18453 632.3247 631.3174 631.3541 -0.0367 0 7 40 1 R.EIGSVK.Y 18501 48136 620.8066 1239.5986 1239.5918 0.0069 0 39 0.006 1 K.YLECSALTQR.G

173. Q08379|GOGA2_HUMAN Mass: 112217 Score: 39 Queries matched: 59 emPAI: 0.03 Golgin subfamily A member 2 OS=Homo sapiens GN=GOLGA2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14351 545.3129 544.3056 544.2605 0.0451 0 1 2e+002 9 R.EGSPR.D 3389 424.2787 846.5429 846.4269 0.1160 0 7 20 1 R.ALQGAMEK.L 3323 3351 3375 3441 25474 429.7555 857.4964 857.4719 0.0245 1 2 43 7 R.GQLKEQR.V 36177 502.2846 1002.5546 1002.5345 0.0200 1 39 0.0079 1 K.SELEEKLR.V 36143 36148 36149 11749 36153 36154 36156 36157 36 13423 529.7843 1057.5541 1057.5880 -0.0339 1 2 43 1 R.ALSQNRELK.E 41284 546.7531 1091.4916 1091.4731 0.0186 0 8 7.9 7 K.EGESEDLASR.L 41285 41288 41289 42654 560.8107 1119.6069 1119.6288 -0.0218 1 3 30 9 R.DALRLELYK.N 50796 651.8696 1301.7246 1301.6324 0.0922 0 12 3.1 4 K.SQEAQSLQQQR.D 50774 50775 50776 50780 50783 50784 50785 5078 51819 665.8557 1329.6969 1329.6313 0.0656 0 8 7.5 6 R.AAELWGEQAEAR.R 12524 515.3116 1542.9129 1542.7824 0.1304 0 9 23 1 R.DNPTAQQIM QLLR.E

174. P59998|ARPC4_HUMAN Mass: 19768 Score: 39 Queries matched: 6 emPAI: 0.19 Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens GN=ARPC4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12043 505.2904 1008.5663 1008.5392 0.0271 0 11 16 1 R.AENFFILR.R 36437 42124 554.3085 1106.6024 1106.5832 0.0192 0 13 2.8 1 R.HNKPEVEVR.S 17185 599.2463 1196.4781 1196.4963 -0.0182 1 3 52 2 K.FMRFM MMR.A 49370 634.8859 1267.7571 1267.7500 0.0072 0 39 0.0058 1 K.ELLLQPVTISR.N 63472 532.8904 2659.4155 2659.2992 0.1163 0 0 16 1 R.KPVEGYDISFLITNFHTEQMYK.H

175. P31949|S10AB_HUMAN Mass: 11847 Score: 38 Queries matched: 6 emPAI: 0.78 Protein S100-A11 OS=Homo sapiens GN=S100A11 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 36877 510.2545 1018.4943 1018.4931 0.0013 0 34 0.026 1 K.ISSPTETER.C 36878 36879 39214 530.7571 1059.4996 1059.4873 0.0124 0 1 48 3 K.DGYNYTLSK.T 43742 571.3016 1140.5886 1140.5887 -0.0001 1 27 0.1 1 K.NQKDPGVLDR.M 55375 493.9162 1478.7268 1478.7041 0.0227 1 13 2.2 1 K.YAGKDGYNYTLSK.T

176. P02654|APOC1_HUMAN Mass: 9326 Score: 38 Queries matched: 2 emPAI: 0.43 Apolipoprotein C-I OS=Homo sapiens GN=APOC1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 36228 502.3034 1002.5922 1002.5709 0.0213 1 38 0.0087 1 R.IKQSELSAK.M 36230

177. Q99497|PARK7_HUMAN Mass: 20050 Score: 38 Queries matched: 12 emPAI: 0.69 Protein DJ-1 OS=Homo sapiens GN=PARK7 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25925 433.7619 865.5092 865.5022 0.0071 0 28 0.083 1 K.VTTHPLAK.D 25927 27865 437.7551 873.4956 873.4920 0.0037 0 8 13 2 K.DGLILTSR.G 28489 442.2410 882.4674 882.6014 -0.1340 1 4 18 1 K.RALVILAK.G 28681 44448 579.8116 1157.6086 1157.6040 0.0046 1 35 0.017 1 K.EILKEQENR.K 56817 553.3023 1656.8851 1656.8618 0.0233 1 14 1.6 1 K.VTVAGLAGKDPVQCSR.D 56819 553.9474 1658.8203 1658.8185 0.0018 1 18 0.62 1 R.DVVICPDASLEDAKK.E 57088 854.3959 1706.7773 1706.7855 -0.0082 0 2 21 2 K.GAEEMETVIPVDVMR.R 57078 15757 57090

178. P05089|ARGI1_HUMAN Mass: 34884 Score: 38 Queries matched: 11 emPAI: 0.11 Arginase-1 OS=Homo sapiens GN=ARG1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 41837 552.3283 1102.6420 1102.6386 0.0033 0 38 0.01 1 R.TIGIIGAPFSK.G 41835 48150 621.3406 1240.6666 1240.6776 -0.0110 1 23 0.22 1 R.GGVEEGPTVLRK.A 50114 643.3672 1284.7198 1284.6350 0.0848 0 3 21 3 R.DVDPGEHYILK.T 51812 665.3815 1328.7484 1328.7299 0.0185 1 6 12 4 K.ASEQLAGKVAEVK.K 51803 51805 51806 51807 51809 56820 830.4198 1658.8251 1658.8338 -0.0087 1 11 2.9 2 K.TLGIKYFSMTEVDR.L

179. P16070|CD44_HUMAN Mass: 82017 Score: 38 Queries matched: 7 emPAI: 0.09

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CD44 antigen OS=Homo sapiens GN=CD44 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19823 718.4168 717.4095 717.3406 0.0690 0 3 41 2 R.NDVTGGR.R 30658 454.2211 906.4276 906.4117 0.0160 0 28 0.087 1 R.TEAADLCK.A 30656 30657 12711 517.2823 1032.5501 1032.5393 0.0108 0 27 0.5 1 R.FAGVFHVEK.N 61340 421.0456 2520.2298 2520.2948 -0.0649 1 2 16 1 K.ALSIGFETCRYGFIEGHVVIPR.I 61362

180. Q8TER0|SNED1_HUMAN Mass: 158206 Score: 37 Queries matched: 40 emPAI: 0.02 Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens GN=SNED1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12735 517.3003 516.2930 516.3020 -0.0089 0 5 58 1 K.AATVR.S 17137 598.3475 597.3402 597.3850 -0.0448 0 3 56 1 R.ALLPGK.R 20680 405.2313 808.4481 808.4443 0.0038 0 34 0.02 2 K.LASYTVR.D 20565 20569 20571 587 20584 20590 20593 594 20603 20 36878 510.2598 1018.5050 1018.4753 0.0297 0 8 9.2 4 R.EATDPAMLR.R 44460 580.2942 1158.5739 1158.5815 -0.0076 1 7 13 2 R.EATDPAMLRR.A 45103 588.2840 1174.5535 1174.5764 -0.0229 1 (0) 50 8 R.EATDPAMLRR.A 16757 589.3338 1176.6530 1176.6251 0.0279 1 5 63 1 R.FGGSPSKAATVR.S 16762 16764 52530 676.3443 1350.6740 1350.5293 0.1447 0 1 36 4 R.SPCVNGGTCEDR.D

181. P37837|TALDO_HUMAN Mass: 37688 Score: 37 Queries matched: 13 emPAI: 0.21 Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22094 413.7755 825.5364 825.5324 0.0040 0 27 0.094 1 K.LVPVLSAK.A 22095 22099 30660 454.2232 906.4318 906.4593 -0.0275 1 1 45 6 -.M SSSPVKR.Q 11519 499.2887 996.5629 996.5063 0.0567 0 6 31 2 K.TIVM GASFR.N 40194 537.7855 1073.5564 1073.5353 0.0211 0 12 3.9 1 K.LGGSQEDQIK.N 40157 40161 40172 40186 47641 617.3067 1232.5989 1232.5925 0.0064 0 38 0.0085 1 K.SYEPLEDPGVK.S 52830 681.3542 1360.6937 1360.6874 0.0063 1 4 22 7 K.KSYEPLEDPGVK.S 52840

182. Q5D1E8|ZC12A_HUMAN Mass: 66285 Score: 36 Queries matched: 13 emPAI: 0.06 Ribonuclease ZC3H12A OS=Homo sapiens GN=ZC3H12A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9107 463.2739 924.5332 924.4552 0.0780 0 2 1e+002 1 K.EQASVYTK.L 9120 463.7104 925.4063 925.3964 0.0100 0 5 14 1 R.VVCYDDR.F 31779 32345 466.7451 931.4756 931.5491 -0.0735 0 4 23 10 K.ILVFTPSR.R 32342 32348 39220 530.7811 1059.5476 1059.6441 -0.0965 1 36 0.015 3 K.KILVFTPSR.R 39219 39221 39224 39238 39241 39267

183. Q96CB9|NSUN4_HUMAN Mass: 43631 Score: 36 Queries matched: 690 emPAI: 0.09 Putative methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 26826 435.7654 869.5162 869.4971 0.0191 0 33 0.026 1 R.VDLATVPR.R 26408 26413 26414 26416 26418 26420 26421 26422 26430 32149 465.7611 929.5076 929.4970 0.0106 1 21 0.47 2 K.KWAATEPK.F 32142

184. P59665|DEF1_HUMAN Mass: 10536 Score: 36 Queries matched: 3 emPAI: 0.38 Neutrophil defensin 1 OS=Homo sapiens GN=DEFA1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 35096 493.7555 985.4965 985.5015 -0.0050 0 25 0.2 1 R.IPACIAGER.R 11254 42459 559.2604 1116.5063 1116.5022 0.0041 0 36 0.014 1 R.YGTCIYQGR.L

Proteins matching the same set of peptides: P59666|DEF3_HUMAN Mass: 10580 Score: 36 Queries matched: 3 Neutrophil defensin 3 OS=Homo sapiens GN=DEFA3 PE=1 SV=1

185. Q9Y490|TLN1_HUMAN Mass: 271766 Score: 36 Queries matched: 14 emPAI: 0.01 Talin-1 OS=Homo sapiens GN=TLN1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18046 618.3373 617.3300 617.3748 -0.0448 0 3 61 3 K.LISSAK.Q 18895 647.3928 646.3855 646.3286 0.0569 0 5 47 3 R.AVGDASK.R 20187 403.2246 804.4347 804.4164 0.0183 0 6 17 7 R.AIADMLR.A 20367 404.2356 806.4566 806.4286 0.0280 0 5 21 2 R.QFVQSAK.E 33064 473.2653 944.5160 944.5225 -0.0065 1 4 29 9 R.RAIADMLR.A 33039 36513 507.2568 1012.4990 1012.4937 0.0053 0 36 0.012 1 R.SAQPASAEPR.Q 38102 522.7771 1043.5397 1043.5110 0.0287 0 5 17 4 K.ALDYYMLR.N 39717 533.3090 1064.6034 1064.5138 0.0895 0 2 32 2 K.TSTPEDFIR.M 40855 542.7407 1083.4668 1083.6652 -0.1984 0 0 45 6 K.AVASAAAALVLK.A 15784 570.7896 1139.5646 1139.5935 -0.0288 0 4 19 4 R.ALEATTEHIR.Q 45531 591.2803 1180.5461 1180.5216 0.0245 1 2 34 5 K.ECVM RVDEK.T 18729 642.3914 1282.7682 1282.7972 -0.0290 1 2 67 4 K.AVASAAAALVLKAK.S 51351 658.8242 1315.6337 1315.6732 -0.0394 0 10 4.9 2 R.QEDVIATANLSR.R

186. P15336|ATF2_HUMAN Mass: 54789 Score: 36 Queries matched: 6 emPAI: 0.07 Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens GN=ATF2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 39679 533.2671 1064.5195 1064.4631 0.0565 0 36 0.014 2 K.DCPVTAMQK.K 13705 39687 39695 39696 39705

187. P02452|CO1A1_HUMAN Mass: 139853 Score: 35 Queries matched: 12 emPAI: 0.03 Collagen alpha-1(I) chain OS=Homo sapiens GN=COL1A1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13485 530.3005 529.2932 529.2609 0.0324 0 1 69 1 R.GGPGSR.G 14235 544.2784 543.2711 543.2653 0.0058 0 15 5.9 9 R.GDAGPK.G 14264 14299 24484 426.2214 850.4282 850.4185 0.0098 0 22 0.31 1 R.GFSGLDGAK.G 27684 436.7602 871.5058 871.4148 0.0910 1 11 5.6 2 K.GDRGDAGPK.G 33050 473.2636 944.5127 944.4312 0.0816 0 10 7.2 1 K.QGPSGASGER.G 33084 40871 542.7548 1083.4950 1083.4945 0.0005 0 0 48 10 R.EGAPGAEGSPGR.D

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41055 545.3000 1088.5854 1088.5727 0.0127 0 35 0.017 1 R.GVQGPPGPAGPR.G 15041 558.3444 1114.6742 1114.5367 0.1375 1 3 69 1 K.GADGSPGKDGVR.G 51868 667.8537 1333.6928 1333.6739 0.0190 1 19 0.56 1 K.GPAGERGSPGPAGPK.G

188. P11413|G6PD_HUMAN Mass: 59675 Score: 35 Queries matched: 6 emPAI: 0.06 Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens GN=G6PD PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25556 432.2248 862.4350 862.4185 0.0165 0 17 1.4 1 K.LPDAYER.L 28326 441.7264 881.4382 881.4283 0.0099 0 2 27 4 K.QSEPFFK.A 30085 450.2771 898.5397 898.5348 0.0049 1 19 0.57 1 K.RNELVIR.V 43249 566.7948 1131.5750 1131.5560 0.0190 0 35 0.017 1 K.GYLDDPTVPR.G 43237 43239

189. P60903|S10AA_HUMAN Mass: 11310 Score: 35 Queries matched: 1 emPAI: 0.35 Protein S100-A10 OS=Homo sapiens GN=S100A10 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 41545 550.2712 1098.5279 1098.5710 -0.0431 1 35 0.017 1 K.FAGDKGYLTK.E

190. P63218|GBG5_HUMAN Mass: 7428 Score: 35 Queries matched: 10 emPAI: 0.56 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens GN=GNG5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 30360 451.7541 901.4937 901.4869 0.0068 0 35 0.023 1 K.VSQAAADLK.Q 9083 462.7444 923.4743 923.4382 0.0361 0 6 13 5 M.SGSSSVAAMK.K 35825 500.2656 998.5167 998.5873 -0.0706 1 3 27 1 R.LEAGLNRVK.V 40992 544.3155 1086.6164 1086.4685 0.1479 0 5 20 5 -.MSGSSSVAAMK.K 40989 40994 46266 600.3537 1198.6928 1198.5686 0.1242 1 6 12 1 -.MSGSSSVAAMKK.V 17689 608.3442 1214.6739 1214.5635 0.1104 1 (1) 1.2e+002 1 -.MSGSSSVAAMKK.V 46877 11516 499.2842 1494.8307 1494.8630 -0.0323 1 1 93 1 K.VVQQLRLEAGLNR.V

191. P15924|DESP_HUMAN Mass: 334021 Score: 35 Queries matched: 87 emPAI: 0.03 Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17942 616.3867 615.3794 615.3704 0.0091 0 2 83 7 R.NLTIR.S 18037 618.3273 617.3200 617.3384 -0.0184 0 6 48 1 K.TELQK.A 18355 630.3941 629.3869 629.3497 0.0372 0 4 64 1 K.NLIDR.E 24169 422.7144 843.4142 843.4086 0.0055 0 25 0.24 1 R.AESGPDLR.Y 3193 28526 442.2455 882.4765 882.4521 0.0245 0 7 9.7 2 R.FLSEMLK.S 28652 8027 452.3224 902.6303 902.5371 0.0932 1 4 36 2 K.IRAMTIAK.L 30599 453.7333 905.4521 905.4454 0.0067 0 31 0.053 1 K.STLEAETR.V 30592 30597 30600 30602 31480 458.7637 915.5129 915.5389 -0.0260 1 7 12 3 R.SLKEQAIK.I 32604 470.7942 939.5738 939.5865 -0.0127 0 7 11 3 R.SNKPIILR.A 32585 32591 33120 473.7556 945.4966 945.5243 -0.0277 1 1 52 10 K.KQVQTSQK.N 33318 476.2363 950.4581 950.4345 0.0236 0 4 24 5 K.AEFQEEAK.R 33653 479.7533 957.4921 957.5243 -0.0322 1 4 23 2 K.VLEQDKAR.L 35901 500.7788 999.5430 999.4998 0.0432 0 11 4.6 2 R.QRPYGSHR.E 35916 501.2662 1000.5179 1000.5414 -0.0234 1 3 32 6 R.NQLDRLSR.E 36572 507.8015 1013.5884 1013.5505 0.0378 0 2 37 9 K.QQLEVELR.Q 37124 512.2663 1022.5181 1022.4525 0.0657 0 8 8 2 K.ACGSEIMQK.K 38205 523.2871 1044.5597 1044.5564 0.0033 0 7 11 3 R.GIVDSITGQR.L 38140 38146 38151 38187 38194 38229 13252 527.2312 1052.4478 1052.4557 -0.0078 1 0 1.1e+002 2 K.RTASEDSCK.R 39141 530.2873 1058.5600 1058.5468 0.0132 0 2 33 1 R.SQLQISNNR.T 41094 545.3168 1088.6190 1088.6124 0.0066 1 1 51 1 R.INTLGRMIR.A 42118 554.2835 1106.5525 1106.5356 0.0169 1 8 9.8 10 K.AEFQEEAKR.R 42089 42090 42094 42095 42096 42105 42106 42111 42537 559.7245 1117.4345 1117.4393 -0.0048 0 0 44 6 -.MSCNGGSHPR.I 43184 566.2702 1130.5259 1130.5469 -0.0210 0 3 29 8 R.GIHNSIGDYR.W 43161 15648 43543 568.3311 1134.6477 1134.5517 0.0961 0 1 47 3 K.ANSSATETINK.L 15762 570.2774 1138.5403 1138.6597 -0.1195 0 24 0.51 2 R.AELIVQPELK.Y 15761 43681 43683 43684 15764 15769 45021 585.7750 1169.5354 1169.5313 0.0041 0 19 0.59 1 R.YEVTSGGGGTSR.M 45022 47055 610.7962 1219.5779 1219.5680 0.0098 0 14 2.3 1 R.ETQSQLETER.S 47054 48197 622.3662 1242.7178 1242.6932 0.0247 1 4 16 3 K.LKVQEQELTR.L 49977 642.3402 1282.6659 1282.5976 0.0683 1 10 4.6 2 K.DMLANFRGSEK.Y 4580 430.8991 1289.6756 1289.6575 0.0181 0 9 5.9 1 K.NTLTQTTENLR.R 4501 4510 4516 4523 4524 4531 4536 4539 4541 4 50351 647.3596 1292.7046 1292.5415 0.1631 1 2 32 1 R.DANSENCNKNK.F 5792 434.8859 1301.6358 1301.6840 -0.0483 1 2 29 9 K.VTQLTDRWQR.I 51818 665.8418 1329.6691 1329.6888 -0.0197 1 3 25 8 R.GAGSIAGASASPKEK.Y 19743 710.4054 1418.7963 1418.6612 0.1350 1 2 71 1 R.QCEKENLGWQK.L 54463 10653 485.2434 1452.7083 1452.6732 0.0350 0 1 1e+002 6 K.TGSQYDIQDAIDK.G 55308 738.3968 1474.7790 1474.8143 -0.0354 1 6 11 8 R.FQNSLKELQLQK.Q 59090 414.0397 2065.1620 2065.0125 0.1495 1 0 21 6 K.SLVSWHYCMIDIEKIR.A

192. Q04917|1433F_HUMAN Mass: 28372 Score: 34 Queries matched: 6 emPAI: 0.13 14-3-3 protein eta OS=Homo sapiens GN=YWHAH PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7978 452.2556 902.4966 902.5073 -0.0106 0 26 0.36 1 R.VISSIEQK.T 30673 454.2644 906.5143 906.5174 -0.0031 0 33 0.033 1 R.NLLSVAYK.N 30674 30676 30679 46010 597.8145 1193.6145 1193.6292 -0.0147 1 19 0.61 1 R.YLAEVASGEKK.N

193. P27348|1433T_HUMAN Mass: 28032 Score: 34 Queries matched: 9 emPAI: 0.29 14-3-3 protein theta OS=Homo sapiens GN=YWHAQ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7978 452.2556 902.4966 902.5073 -0.0106 0 26 0.36 1 R.VISSIEQK.T 30673 454.2644 906.5143 906.5174 -0.0031 0 33 0.033 1 R.NLLSVAYK.N 30674 30676 30679 35368 495.2736 988.5327 988.5189 0.0138 1 9 7.9 4 R.EKVESELR.S 35407 42225 554.7760 1107.5374 1107.5495 -0.0121 0 19 0.61 1 K.EMQPTHPIR.L 55954 511.5931 1531.7574 1531.7114 0.0460 0 3 22 1 K.AVTEQGAELSNEER.N

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194. P06744|G6PI_HUMAN Mass: 63335 Score: 34 Queries matched: 9 emPAI: 0.12 Glucose-6-phosphate isomerase OS=Homo sapiens GN=GPI PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24187 423.1828 844.3510 844.3926 -0.0417 0 5 24 3 K.SPEDLER.L 24191 24194 3264 24560 426.7117 851.4089 851.4137 -0.0048 0 17 1 1 K.INYTEGR.A 24563 38634 524.8277 1047.6408 1047.5746 0.0662 1 1 43 2 R.M LVDLAKSR.G 46999 609.8344 1217.6543 1217.6404 0.0138 0 34 0.025 1 K.HFVALSTNTTK.V 64274 455.5981 2727.5452 2727.3517 0.1934 1 3 5.6 1 K.DRFNHFSLTLNTNHGHILVDYSK.N

195. Q9NQP4|PFD4_HUMAN Mass: 15419 Score: 34 Queries matched: 6 emPAI: 0.25 Prefoldin subunit 4 OS=Homo sapiens GN=PFDN4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21170 406.7549 811.4953 811.3932 0.1022 1 8 6.5 2 -.MAATMKK.A 21168 39326 531.2952 1060.5759 1060.5876 -0.0117 1 1 41 1 R.NTSRITELK.E 51819 665.8557 1329.6969 1329.7391 -0.0422 1 34 0.019 1 R.ITELKEEIEVK.K 51820 51821

196. O00626|CCL22_HUMAN Mass: 10802 Score: 34 Queries matched: 4 emPAI: 0.37 C-C motif chemokine 22 OS=Homo sapiens GN=CCL22 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21483 409.2604 816.5063 816.4970 0.0093 1 11 5.4 1 R.YRLPLR.V 33136 473.7698 945.5251 945.5317 -0.0066 1 2 41 6 K.MILNKLSQ.- 41771 552.2651 1102.5157 1102.5077 0.0080 1 34 0.025 1 R.DKEICADPR.V 41772

197. O95359|TACC2_HUMAN Mass: 311632 Score: 33 Queries matched: 22 emPAI: 0.01 Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens GN=TACC2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19680 702.4013 701.3940 701.3708 0.0232 0 3 40 1 R.VDALER.T 249 401.7009 801.3872 801.3981 -0.0108 0 6 19 5 K.AVSSADPR.A 27793 437.2567 872.4989 872.4716 0.0274 0 7 13 3 R.TLSAQTPR.S 6341 27797 6370 27810 27813 27816 27821 27830 437.2731 872.5317 872.4828 0.0489 1 8 12 2 K.AGAGRSAVGK.D 27817 32377 467.2336 932.4527 932.4815 -0.0288 0 12 3.8 2 K.STDSVPISK.S 9995 474.2815 946.5484 946.4542 0.0942 1 2 1.4e+002 2 K.DAPRVMDK.V 33790 480.2666 958.5187 958.5447 -0.0260 1 33 0.029 2 R.AEIITKER.E 33767 13157 523.2952 1044.5759 1044.5312 0.0447 1 7 30 1 K.NQEGKVNTR.R 38147 4627 431.8934 1292.6584 1292.6468 0.0116 1 4 20 2 K.ICDELIAKMGK.S 52475 675.2380 1348.4614 1348.6293 -0.1679 0 4 9.9 1 K.TIAQMIEDEQR.E 54865 722.3334 1442.6523 1442.7015 -0.0492 1 4 16 4 R.DHPSSHSAQPPRK.G 56429 797.8877 1593.7607 1593.7747 -0.0139 1 9 4.3 4 K.APSESARGPPGPTDGAK.V

198. Q02413|DSG1_HUMAN Mass: 114670 Score: 33 Queries matched: 9 emPAI: 0.03 Desmoglein-1 OS=Homo sapiens GN=DSG1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 32457 467.7701 933.5256 933.4152 0.1105 1 3 30 6 R.EGEDNSKR.N 10621 484.7900 967.5654 967.3964 0.1691 1 5 16 1 R.NSMRECR.E 10629 38934 528.2710 1054.5274 1054.4753 0.0521 0 2 35 1 K.EQYNMLGGK.Y 38904 14381 546.2659 1090.5172 1090.4713 0.0459 0 16 5.6 1 R.EMQDLGGGER.M 15142 560.2904 1118.5662 1118.5568 0.0094 0 13 11 1 R.ESSNVVVTER.V 42586 56831 554.9240 1661.7503 1661.7580 -0.0077 0 33 0.017 1 K.IHSDCAANQQVTYR.I

199. Q00610|CLH1_HUMAN Mass: 193260 Score: 33 Queries matched: 13 emPAI: 0.04 Clathrin heavy chain 1 OS=Homo sapiens GN=CLTC PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24653 427.2192 852.4238 852.4164 0.0075 0 5 14 2 K.YIQAACK.T 25470 429.7458 857.4770 857.4719 0.0051 1 1 54 1 R.TPDTIRR.F 31692 462.7052 923.3958 923.4535 -0.0577 0 5 15 3 R.VMEYINR.L 13061 522.2759 1042.5373 1042.4356 0.1018 0 2 1.1e+002 7 R.ENPYYDSR.V 39141 530.2873 1058.5600 1058.5720 -0.0120 1 2 38 2 K.TGQIKEVER.I 39838 535.2782 1068.5419 1068.5386 0.0034 0 24 0.2 1 R.AHIAQLCEK.A 43747 571.3279 1140.6412 1140.6615 -0.0203 1 1 39 10 K.GILRTPDTIR.R 45305 589.7862 1177.5578 1177.6343 -0.0765 1 2 37 7 K.EGQFKDIITK.V 19299 667.8259 1333.6373 1333.6262 0.0111 0 29 0.056 1 K.IYIDSNNNPER.F 10589 484.3077 1449.9012 1449.7365 0.1647 1 0 93 1 R.LDHTRAVNYFSK.V 14280 544.3287 1629.9642 1629.7787 0.1855 0 0 1.7e+002 2 K.FNALFAQGNYSEAAK.V 60689 1178.5149 2355.0152 2355.2119 -0.1967 1 4 9 1 R.AHMGMFTELAILYSKFKPQK.M 60695

200. O43150|ASAP2_HUMAN Mass: 112835 Score: 33 Queries matched: 23 emPAI: 0.03 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens GN=ASAP2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 33853 480.7444 959.4742 959.4825 -0.0082 0 2 45 3 R.ELGVHYSR.M 34541 487.2760 972.5374 972.5240 0.0135 0 33 0.034 2 K.EIISEVQR.M 10832 10837 10839 10841 10844 10845 10846 34505 34 35889 500.7662 999.5179 999.6077 -0.0898 1 8 11 1 K.SQATKLKPK.R 40523 539.7631 1077.5116 1077.5051 0.0065 0 23 0.3 1 K.TNSVSVDGGSR.Q 65165 573.0727 2860.3271 2860.4463 -0.1192 0 1 14 1 R.GPVDLSATEALGPLSNAM VLQPPAPMPR.K

201. Q9UBR2|CATZ_HUMAN Mass: 34530 Score: 33 Queries matched: 26 emPAI: 0.11 Cathepsin Z OS=Homo sapiens GN=CTSZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 36467 505.7564 1009.4983 1009.4829 0.0155 0 33 0.025 1 R.VGDYGSLSGR.E 36464 36465 42404 556.3047 1110.5948 1110.5921 0.0028 1 22 0.32 2 R.IVTSTYKDGK.G 42382 42384 42385 42386 14972 42387 42388 42389 4

202. Q15050|RRS1_HUMAN Mass: 41225 Score: 33 Queries matched: 37 emPAI: 0.09 Ribosome biogenesis regulatory protein homolog OS=Homo sapiens GN=RRS1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24341 424.7543 847.4940 847.4334 0.0607 1 11 5.9 3 R.ATNKQMR.E 24324 24328 24332 24346 24348

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9730 472.2311 942.4476 942.5246 -0.0771 1 1 1.4e+002 5 R.VAKNELNR.L 35639 497.7946 993.5747 993.6083 -0.0336 1 33 0.029 2 K.LQRITVHK.E 35617 35619 35620 11392 35621 35622 35623 35625 46364 601.7999 1201.5853 1201.6190 -0.0337 0 10 5.3 3 M.EGQSVEELLAK.A 46369 47549 616.3468 1230.6791 1230.6390 0.0401 1 3 29 3 K.EELGRAMQVAK.V 9963 474.2722 1419.7949 1419.7504 0.0445 1 4 98 1 R.AMQVAKVSTASVGR.F

203. Q9NW13|RBM28_HUMAN Mass: 86198 Score: 33 Queries matched: 26 emPAI: 0.04 RNA-binding protein 28 OS=Homo sapiens GN=RBM28 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14262 544.3021 543.2949 543.3017 -0.0068 0 11 15 4 R.KPDGK.M 14239 14263 14299 14492 547.2780 546.2707 546.2649 0.0058 0 1 1e+002 5 K.AVDDK.Q 2115 416.2909 830.5673 830.4432 0.1241 1 10 32 1 R.KPDGKMR.G 2106 2107 22345 2208 2216 2217 3496 424.3237 846.6328 846.4382 0.1947 1 (10) 4.5 1 R.KPDGKMR.G 3443 3486 13456 530.2828 1058.5510 1058.5760 -0.0250 0 8 30 5 R.TVAVDWAVAK.D 39121 40672 540.7803 1079.5459 1079.5798 -0.0338 0 33 0.028 1 -.MAGLTLFVGR.L 40674 40675 40677 40680 50792 651.8682 1301.7218 1301.6980 0.0239 1 6 12 5 R.TVAVDWAVAKDK.Y 50781 19129 657.3915 1312.7684 1312.6510 0.1174 0 1 93 1 K.AEVEQVELPDGK.K 6517 439.8730 1316.5970 1316.7564 -0.1594 1 9 6 3 R.NLYLAREGLIR.A

204. Q96R72|OR4K3_HUMAN Mass: 35898 Score: 32 Queries matched: 29 emPAI: 0.10 Olfactory receptor 4K3 OS=Homo sapiens GN=OR4K3 PE=3 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 40143 537.7753 1073.5360 1073.5982 -0.0622 1 27 0.13 1 K.LSSHIFKSR.K 40139 40142 40145 40146 40148 40150 40151 40152 4

205. P05107|ITB2_HUMAN Mass: 87976 Score: 32 Queries matched: 21 emPAI: 0.09 Integrin beta-2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21265 407.2589 812.5032 812.5007 0.0024 0 12 2.9 1 K.LTEIIPK.S 6225 436.2275 870.4404 870.5287 -0.0882 1 7 30 1 K.KLGGDLLR.A 27554 27555 27618 6251 6257 6258 6262 6286 6292 630 38533 524.2548 1046.4950 1046.4815 0.0135 0 28 0.086 1 R.TTEGCLNPR.R 41037 545.2459 1088.4772 1088.5462 -0.0690 0 3 31 3 R.ALNEITESGR.I 44287 576.7574 1151.5003 1151.4877 0.0126 0 26 0.14 1 R.SSQELEGSCR.K 53749 694.8553 1387.6960 1387.6732 0.0228 0 12 3.2 2 K.LNFTGPGDPDSIR.C 53753 11293 494.9413 1481.8020 1481.7878 0.0142 0 24 0.16 1 R.VFLDHNALPDTLK.V 57012 564.6092 1690.8056 1690.7951 0.0105 0 12 2.3 1 R.SNEFDYPSVGQLAHK.L 66461 514.6628 3081.9331 3081.7446 0.1884 1 6 0.26 1 M.LGLRPPLLALVGLLSLGCVLSQECTKFK.V

206. P08571|CD14_HUMAN Mass: 40678 Score: 32 Queries matched: 8 emPAI: 0.09 Monocyte differentiation antigen CD14 OS=Homo sapiens GN=CD14 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25460 429.7401 857.4656 857.3879 0.0777 0 3 38 2 R.VDADADPR.Q 31000 456.7646 911.5147 911.4825 0.0322 0 34 0.017 1 R.ATVNPSAPR.C 30989 30998 34790 488.7548 975.4951 975.4808 0.0144 0 17 1.2 1 R.VLDLSCNR.L 36560 507.7588 1013.5030 1013.4890 0.0140 1 10 5.7 4 K.RVDADADPR.Q 36555 46353 401.2435 1200.7086 1200.6965 0.0121 1 7 9.2 1 R.LKELTLEDLK.I

207. Q9H0J4|QRIC2_HUMAN Mass: 181228 Score: 32 Queries matched: 36 emPAI: 0.02 Glutamine-rich protein 2 OS=Homo sapiens GN=QRICH2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17884 615.2488 614.2415 614.3864 -0.1448 1 3 64 5 K.AKLQR.Q 27862 437.7545 873.4945 873.4807 0.0137 0 10 7.9 4 R.VTVADIEK.E 27854 27856 27860 27873 27876 27878 27882 27883 27 28671 442.2840 882.5534 882.4784 0.0750 1 4 19 7 R.QQQPRAR.D 30843 455.7240 909.4334 909.4299 0.0035 0 1 44 4 K.MLMNIEK.V 31439 458.2621 914.5096 914.5185 -0.0089 1 2 38 6 K.ELKAGELR.L 31441 8709 32355 466.7493 931.4839 931.5451 -0.0611 1 32 0.037 2 K.SALATKVSR.V 32343 32347 32349 32350 32351 32352 32353 32354 3 11087 490.2702 978.5258 978.4692 0.0566 0 12 11 1 R.LLTEMDNK.L 11101 39835 534.8393 1067.6641 1067.5724 0.0917 0 0 41 5 R.GLVQPGVDQR.G 40994 544.3193 1086.6240 1086.5822 0.0419 1 3 28 6 K.QLLEDRWK.S 46208 599.3486 1196.6826 1196.6765 0.0061 1 0 41 3 K.LDRLELDPVK.Q

208. P28838|AMPL_HUMAN Mass: 56530 Score: 32 Queries matched: 6 emPAI: 0.07 Cytosol aminopeptidase OS=Homo sapiens GN=LAP3 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24391 425.2432 848.4719 848.4643 0.0075 0 5 22 1 R.FAEIIEK.N 16457 584.2980 1166.5814 1166.5754 0.0061 0 23 0.53 1 R.SAGACTAAAFLK.E 17962 616.8483 1231.6820 1231.6673 0.0147 0 2 32 2 K.GVLFASGQNLAR.Q 6521 440.2078 1317.6015 1317.6161 -0.0146 0 7 40 1 K.TIQVDNTDAEGR.L 6550 55896 763.4160 1524.8175 1524.7936 0.0238 0 32 0.028 1 K.GSPNANEPPLVFVGK.G

209. Q9NZT1|CALL5_HUMAN Mass: 15883 Score: 32 Queries matched: 8 emPAI: 0.55 Calmodulin-like protein 5 OS=Homo sapiens GN=CALML5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 32143 465.7555 929.4963 929.4930 0.0033 0 25 0.19 1 K.NLSEAQLR.K 32144 32145 32146 32150 39114 529.8049 1057.5952 1057.5880 0.0072 1 29 0.079 1 K.NLSEAQLRK.L 39115 60016 557.8295 2227.2889 2227.1089 0.1800 1 0 14 2 R.RAM AGLGQPLPQEELDAMIR.E

210. Q07617|SPAG1_HUMAN Mass: 104714 Score: 32 Queries matched: 5 emPAI: 0.04 Sperm-associated antigen 1 OS=Homo sapiens GN=SPAG1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19150 660.3649 659.3577 659.3490 0.0087 0 8 26 2 K.IDGDIK.S 34497 487.2541 972.4937 972.4512 0.0425 0 6 16 5 R.GQTPEAGADK.R 41157 545.8064 1089.5982 1089.5567 0.0416 1 3 32 1 R.ATTYKHQNK.L 44448 579.8116 1157.6086 1157.5928 0.0158 0 32 0.04 2 K.IEIQEVNEGK.E 47486 614.3132 1226.6119 1226.6767 -0.0648 1 4 17 5 R.FKMMLTLISK.G

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211. Q9UP38|FZD1_HUMAN Mass: 72423 Score: 31 Queries matched: 27 emPAI: 0.05 Frizzled-1 OS=Homo sapiens GN=FZD1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 42546 559.7700 1117.5255 1117.5000 0.0255 0 6 12 3 R.LAEEGSGDAGGR.R 56205 783.8875 1565.7605 1565.7878 -0.0273 0 31 0.032 1 K.VPSYLNYHFLGEK.D 56178 56179 56180 56183 56184 56185 56186 561

212. Q13029|PRDM2_HUMAN Mass: 191135 Score: 30 Queries matched: 13 emPAI: 0.02 PR domain zinc finger protein 2 OS=Homo sapiens GN=PRDM2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19244 663.3814 662.3741 662.3612 0.0129 1 3 72 2 K.NAFRR.M 20038 400.2241 798.4336 798.4236 0.0101 0 3 27 6 R.GLPEEVR.L 4476 430.7657 859.5168 859.5127 0.0041 1 1 57 1 K.SKAVLQSK.S 41973 553.7711 1105.5276 1105.5624 -0.0347 0 (3) 29 4 R.KPTTCMLQK.V 42885 561.8348 1121.6551 1121.5573 0.0978 0 6 15 6 R.KPTTCMLQK.V 45885 596.8249 1191.6352 1191.6611 -0.0259 1 4 20 3 K.RLNFSVELSK.M 46498 603.8153 1205.6161 1205.5975 0.0185 1 30 0.046 1 K.KVFGTHTNMR.R 46479 47621 616.8868 1231.7590 1231.7136 0.0455 1 2 32 1 K.AVLQSKSTLASK.K 52220 670.8464 1339.6782 1339.7208 -0.0426 1 1 37 7 K.AVAKNHSAQLSSK.T 53667 693.3061 1384.5976 1384.6987 -0.1011 1 4 16 2 K.QELKDFSYSLR.L 53669 60254 457.0550 2280.2387 2280.1750 0.0637 1 1 17 1 K.AEGTGKTPVQWESVLDLSVHK.K

213. O95202|LETM1_HUMAN Mass: 83986 Score: 30 Queries matched: 11 emPAI: 0.04 LETM1 and EF-hand domain-containing protein 1, mitochondrial OS=Homo sapiens GN=LETM1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3435 424.2946 846.5747 846.4018 0.1729 0 3 47 1 K.ELQAACR.A 24294 39678 533.2668 1064.5191 1064.5978 -0.0787 1 6 15 8 K.QVKHIPESK.L 39680 39697 40672 540.7803 1079.5459 1079.5910 -0.0450 1 30 0.044 2 R.FQLTMRLR.S 40674 40675 40677 40680 43148 565.7652 1129.5158 1129.6230 -0.1072 1 2 35 4 K.EKEELELLK.E

214. Q9UPQ9|TNR6B_HUMAN Mass: 194739 Score: 30 Queries matched: 23 emPAI: 0.02 Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens GN=TNRC6B PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6874 442.2370 882.4594 882.4308 0.0287 0 6 25 1 K.NSQGGPAPR.E 6917 10909 487.7953 973.5761 973.4716 0.1045 0 3 35 1 K.QPTGSDELK.I 34634 10905 37865 519.2860 1036.5575 1036.4383 0.1192 0 4 22 6 R.EEQLM EDK.K 43126 564.8570 1127.6994 1127.5683 0.1311 0 30 0.047 2 R.QQQEQQLAR.M 43125 43127 43128 46863 607.8256 1213.6366 1213.6013 0.0353 0 0 47 8 R.EPNLPTPMTSK.S 47369 613.2889 1224.5632 1224.5445 0.0187 0 3 26 2 K.M TSGVSQGEWK.Q 15702 568.3322 1701.9748 1701.9162 0.0586 0 4 48 2 R.GLHTPVQPLNSSPSLR.A 57751 913.9048 1825.7950 1825.9257 -0.1307 1 9 3.3 1 R.VAVPNGQPPSAARYMPR.E 57738 57750 57752 57765 57767 57770 5777 65089 570.6286 2848.1066 2848.2204 -0.1139 1 3 2 1 R.SSSSTGSEVGGQSTGSNHKAGSSDSHNSGR.R

215. Q0VG06|FP100_HUMAN Mass: 95526 Score: 30 Queries matched: 32 emPAI: 0.04 Fanconi anemia-associated protein of 100 kDa OS=Homo sapiens GN=FAAP100 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22268 415.7299 829.4452 829.4406 0.0046 1 30 0.079 1 K.AVDQRNK.A 22266 22267 22269 22270 22271 22272 22273 22274 2227 49224 633.8649 1265.7153 1265.6364 0.0789 0 4 19 1 R.EPGSQPAGPASLR.A 6319 436.8874 1307.6405 1307.6180 0.0225 0 2 32 2 R.DPVATFLETCR.E

216. P10451|OSTP_HUMAN Mass: 35572 Score: 30 Queries matched: 3 emPAI: 0.11 Osteopontin OS=Homo sapiens GN=SPP1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 34200 483.2648 964.5150 964.4978 0.0172 0 4 24 1 R.GDSVVYGLR.S 37874 519.2968 1036.5790 1036.4309 0.1481 0 0 49 7 K.QADSGSSEEK.Q 53702 694.3250 1386.6354 1386.6263 0.0091 0 30 0.042 1 R.ISHELDSASSEVN.-

217. P30486|1B48_HUMAN Mass: 40679 Score: 30 Queries matched: 7 emPAI: 0.09 HLA class I histocompatibility antigen, B-48 alpha chain OS=Homo sapiens GN=HLA-B PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6858 442.2261 882.4377 882.4195 0.0181 0 6 24 2 K.TNTQTYR.E 6861 28642 31737 463.2590 924.5034 924.5029 0.0005 1 7 8.4 1 K.LERADPPK.T 31738 34173 483.2243 964.4341 964.4250 0.0091 0 30 0.058 1 R.FDSDAASPR.E 34197

218. P30504|1C04_HUMAN Mass: 41368 Score: 30 Queries matched: 4 emPAI: 0.09 HLA class I histocompatibility antigen, Cw-4 alpha chain OS=Homo sapiens GN=HLA-C PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4478 430.7707 859.5269 859.4520 0.0748 1 3 36 4 -.MRVMAPR.T 34173 483.2243 964.4341 964.4250 0.0091 0 30 0.058 1 R.FDSDAASPR.G 34197 50129 643.8001 1285.5856 1285.6091 -0.0236 0 9 6.9 1 R.YFSTSVSWPGR.G

219. O60296|TRAK2_HUMAN Mass: 102268 Score: 30 Queries matched: 34 emPAI: 0.04 Trafficking kinesin-binding protein 2 OS=Homo sapiens GN=TRAK2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 35681 498.2742 994.5339 994.5811 -0.0472 1 30 0.05 2 K.LKEHVIEK.E 35651 11413 35654 35655 35656 35657 35658 35659 41054 545.2988 1088.5829 1088.5826 0.0004 0 2 34 1 R.LSIGESITNR.R 41041 41060 14698 550.3029 1098.5912 1098.5081 0.0831 0 1 1.2e+002 2 K.TETVTYEEK.E

Mascot: http://www.matrixscience.com/

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Mascot Search Results

User : Email : Search title : Database : SwissProt 57.12 (513877 sequences; 180750753 residues) Taxonomy : Homo sapiens (human) (20329 sequences) Timestamp : 12 Feb 2010 at 15:24:11 GMT Enzyme : Trypsin Fixed modifications : Carbamidomethyl (C) Variable modifications : Oxidation (M) Mass values : Monoisotopic Protein Mass : Unrestricted Peptide Mass Tolerance : ± 0.2 Da Fragment Mass Tolerance: ± 0.2 Da Max Missed Cleavages : 1 Instrument type : ESI-QUAD-TOF Number of queries : 15502 Protein hits : P13645|K1C10_HUMAN Keratin, type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 P04264|K2C1_HUMAN Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 P35908|K22E_HUMAN Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 P35527|K1C9_HUMAN Keratin, type I cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 P02533|K1C14_HUMAN Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 P08779|K1C16_HUMAN Keratin, type I cytoskeletal 16 OS=Homo sapiens GN=KRT16 PE=1 SV=4 P02768|ALBU_HUMAN Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 P13647|K2C5_HUMAN Keratin, type II cytoskeletal 5 OS=Homo sapiens GN=KRT5 PE=1 SV=3 P04259|K2C6B_HUMAN Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 Q04695|K1C17_HUMAN Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 P60709|ACTB_HUMAN Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 P08670|VIME_HUMAN Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 P02538|K2C6A_HUMAN Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 P13646|K1C13_HUMAN Keratin, type I cytoskeletal 13 OS=Homo sapiens GN=KRT13 PE=1 SV=4 P81605|DCD_HUMAN Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 Q86Y46|K2C73_HUMAN Keratin, type II cytoskeletal 73 OS=Homo sapiens GN=KRT73 PE=1 SV=1 P19013|K2C4_HUMAN Keratin, type II cytoskeletal 4 OS=Homo sapiens GN=KRT4 PE=1 SV=4 O95678|K2C75_HUMAN Keratin, type II cytoskeletal 75 OS=Homo sapiens GN=KRT75 PE=1 SV=2 P04075|ALDOA_HUMAN Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2 Q2M2I5|K1C24_HUMAN Keratin, type I cytoskeletal 24 OS=Homo sapiens GN=KRT24 PE=1 SV=1 P21333|FLNA_HUMAN Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 P06396|GELS_HUMAN Gelsolin OS=Homo sapiens GN=GSN PE=1 SV=1 P05783|K1C18_HUMAN Keratin, type I cytoskeletal 18 OS=Homo sapiens GN=KRT18 PE=1 SV=2 P08238|HS90B_HUMAN Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4 P00338|LDHA_HUMAN L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 P40121|CAPG_HUMAN Macrophage-capping protein OS=Homo sapiens GN=CAPG PE=1 SV=1 P13796|PLSL_HUMAN Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=5 P02649|APOE_HUMAN Apolipoprotein E OS=Homo sapiens GN=APOE PE=1 SV=1 Q5VSK2|MRC1L_HUMAN Macrophage mannose receptor 1-like protein 1 OS=Homo sapiens GN=MRC1L1 PE=2 SV=1 P07355|ANXA2_HUMAN Annexin A2 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 P15924|DESP_HUMAN Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 P63104|1433Z_HUMAN 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 P14618|KPYM_HUMAN Pyruvate kinase isozymes M1/M2 OS=Homo sapiens GN=PKM2 PE=1 SV=4 Q5VTE0|EF1A3_HUMAN Putative elongation factor 1-alpha-like 3 OS=Homo sapiens GN=EEF1AL3 PE=5 SV=1 P09467|F16P1_HUMAN Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=4 Q8N1N4|K2C78_HUMAN Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=1 SV=2 Q06830|PRDX1_HUMAN Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 P31025|LCN1_HUMAN Lipocalin-1 OS=Homo sapiens GN=LCN1 PE=1 SV=1 P26038|MOES_HUMAN Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 P02786|TFR1_HUMAN Transferrin receptor protein 1 OS=Homo sapiens GN=TFRC PE=1 SV=2 P11142|HSP7C_HUMAN Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 P61626|LYSC_HUMAN Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 P07195|LDHB_HUMAN L-lactate dehydrogenase B chain OS=Homo sapiens GN=LDHB PE=1 SV=2 P52566|GDIR2_HUMAN Rho GDP-dissociation inhibitor 2 OS=Homo sapiens GN=ARHGDIB PE=1 SV=3 P04083|ANXA1_HUMAN OS=Homo sapiens GN=ANXA1 PE=1 SV=2 P52790|HXK3_HUMAN Hexokinase-3 OS=Homo sapiens GN=HK3 PE=1 SV=2 P06733|ENOA_HUMAN Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 P60174|TPIS_HUMAN Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=2 P25311|ZA2G_HUMAN Zinc-alpha-2-glycoprotein OS=Homo sapiens GN=AZGP1 PE=1 SV=1 Q01469|FABP5_HUMAN Fatty acid-binding protein, epidermal OS=Homo sapiens GN=FABP5 PE=1 SV=3 P31146|COR1A_HUMAN Coronin-1A OS=Homo sapiens GN=CORO1A PE=1 SV=4 P54652|HSP72_HUMAN Heat shock-related 70 kDa protein 2 OS=Homo sapiens GN=HSPA2 PE=1 SV=1 P08107|HSP71_HUMAN Heat shock 70 kDa protein 1 OS=Homo sapiens GN=HSPA1A PE=1 SV=5 P23528|COF1_HUMAN Cofilin-1 OS=Homo sapiens GN=CFL1 PE=1 SV=3 P25774|CATS_HUMAN Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 P07737|PROF1_HUMAN Profilin-1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 Q14019|COTL1_HUMAN Coactosin-like protein OS=Homo sapiens GN=COTL1 PE=1 SV=3 P06703|S10A6_HUMAN Protein S100-A6 OS=Homo sapiens GN=S100A6 PE=1 SV=1 P04406|G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 P10599|THIO_HUMAN Thioredoxin OS=Homo sapiens GN=TXN PE=1 SV=3 P27348|1433T_HUMAN 14-3-3 protein theta OS=Homo sapiens GN=YWHAQ PE=1 SV=1 P31949|S10AB_HUMAN Protein S100-A11 OS=Homo sapiens GN=S100A11 PE=1 SV=2 O00299|CLIC1_HUMAN Chloride intracellular channel protein 1 OS=Homo sapiens GN=CLIC1 PE=1 SV=4 P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3 P62988|UBIQ_HUMAN Ubiquitin OS=Homo sapiens GN=RPS27A PE=1 SV=1 P40925|MDHC_HUMAN Malate dehydrogenase, cytoplasmic OS=Homo sapiens GN=MDH1 PE=1 SV=4 P61981|1433G_HUMAN 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 P00558|PGK1_HUMAN Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 PE=1 SV=3 P62258|1433E_HUMAN 14-3-3 protein epsilon OS=Homo sapiens GN=YWHAE PE=1 SV=1 P32119|PRDX2_HUMAN Peroxiredoxin-2 OS=Homo sapiens GN=PRDX2 PE=1 SV=5 P09382|LEG1_HUMAN Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 P29401|TKT_HUMAN Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3

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P18206|VINC_HUMAN OS=Homo sapiens GN=VCL PE=1 SV=4 P36222|CH3L1_HUMAN Chitinase-3-like protein 1 OS=Homo sapiens GN=CHI3L1 PE=1 SV=2 P05109|S10A8_HUMAN Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 Q04917|1433F_HUMAN 14-3-3 protein eta OS=Homo sapiens GN=YWHAH PE=1 SV=4 Q5D862|FILA2_HUMAN Filaggrin-2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 Q9Y490|TLN1_HUMAN Talin-1 OS=Homo sapiens GN=TLN1 PE=1 SV=3 P31946|1433B_HUMAN 14-3-3 protein beta/alpha OS=Homo sapiens GN=YWHAB PE=1 SV=3 P60660|MYL6_HUMAN Myosin light polypeptide 6 OS=Homo sapiens GN=MYL6 PE=1 SV=2 P07197|NFM_HUMAN Neurofilament medium polypeptide OS=Homo sapiens GN=NEFM PE=1 SV=3 Q16352|AINX_HUMAN Alpha- OS=Homo sapiens GN=INA PE=1 SV=2 P60763|RAC3_HUMAN Ras-related C3 botulinum toxin substrate 3 OS=Homo sapiens GN=RAC3 PE=1 SV=1 Q9H299|SH3L3_HUMAN SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 P37837|TALDO_HUMAN Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 Q8TF72|SHRM3_HUMAN Protein Shroom3 OS=Homo sapiens GN=SHROOM3 PE=1 SV=1 P26447|S10A4_HUMAN Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1 P46940|IQGA1_HUMAN Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens GN=IQGAP1 PE=1 SV=1 P05107|ITB2_HUMAN Integrin beta-2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 P15153|RAC2_HUMAN Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens GN=RAC2 PE=1 SV=1 P62942|FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens GN=FKBP1A PE=1 SV=2 P37802|TAGL2_HUMAN Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 P01040|CYTA_HUMAN Cystatin-A OS=Homo sapiens GN=CSTA PE=1 SV=1 P35241|RADI_HUMAN Radixin OS=Homo sapiens GN=RDX PE=1 SV=1 P16150|LEUK_HUMAN Leukosialin OS=Homo sapiens GN=SPN PE=1 SV=1 Q9NZT1|CALL5_HUMAN Calmodulin-like protein 5 OS=Homo sapiens GN=CALML5 PE=1 SV=2 P31944|CASPE_HUMAN Caspase-14 OS=Homo sapiens GN=CASP14 PE=1 SV=2 P00918|CAH2_HUMAN Carbonic anhydrase 2 OS=Homo sapiens GN=CA2 PE=1 SV=2 P31947|1433S_HUMAN 14-3-3 protein sigma OS=Homo sapiens GN=SFN PE=1 SV=1 P20702|ITAX_HUMAN Integrin alpha-X OS=Homo sapiens GN=ITGAX PE=1 SV=3 Q9BQE3|TBA1C_HUMAN Tubulin alpha-1C chain OS=Homo sapiens GN=TUBA1C PE=1 SV=1 P07339|CATD_HUMAN Cathepsin D OS=Homo sapiens GN=CTSD PE=1 SV=1 P11021|GRP78_HUMAN 78 kDa glucose-regulated protein OS=Homo sapiens GN=HSPA5 PE=1 SV=2 P04792|HSPB1_HUMAN Heat shock protein beta-1 OS=Homo sapiens GN=HSPB1 PE=1 SV=2 P11215|ITAM_HUMAN Integrin alpha-M OS=Homo sapiens GN=ITGAM PE=1 SV=2 O75083|WDR1_HUMAN WD repeat-containing protein 1 OS=Homo sapiens GN=WDR1 PE=1 SV=4 P62937|PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens GN=PPIA PE=1 SV=2 P15311|EZRI_HUMAN OS=Homo sapiens GN=EZR PE=1 SV=4 P13639|EF2_HUMAN Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4 O15511|ARPC5_HUMAN Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens GN=ARPC5 PE=1 SV=3 P06753|TPM3_HUMAN Tropomyosin alpha-3 chain OS=Homo sapiens GN=TPM3 PE=1 SV=1 P27482|CALL3_HUMAN Calmodulin-like protein 3 OS=Homo sapiens GN=CALML3 PE=1 SV=2 P08758|ANXA5_HUMAN Annexin A5 OS=Homo sapiens GN=ANXA5 PE=1 SV=2 Q02413|DSG1_HUMAN Desmoglein-1 OS=Homo sapiens GN=DSG1 PE=1 SV=1 P02787|TRFE_HUMAN Serotransferrin OS=Homo sapiens GN=TF PE=1 SV=2 P20930|FILA_HUMAN Filaggrin OS=Homo sapiens GN=FLG PE=1 SV=3 O75223|GGCT_HUMAN Gamma-glutamylcyclotransferase OS=Homo sapiens GN=GGCT PE=1 SV=1 P04080|CYTB_HUMAN Cystatin-B OS=Homo sapiens GN=CSTB PE=1 SV=2 P62805|H4_HUMAN Histone H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 P09960|LKHA4_HUMAN Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 P58546|MTPN_HUMAN Myotrophin OS=Homo sapiens GN=MTPN PE=1 SV=2 Q16555|DPYL2_HUMAN Dihydropyrimidinase-related protein 2 OS=Homo sapiens GN=DPYSL2 PE=1 SV=1 P47929|LEG7_HUMAN Galectin-7 OS=Homo sapiens GN=LGALS7 PE=1 SV=2 P19971|TYPH_HUMAN Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2 P14923|PLAK_HUMAN Junction OS=Homo sapiens GN=JUP PE=1 SV=3 Q86UX7|URP2_HUMAN Fermitin family homolog 3 OS=Homo sapiens GN=FERMT3 PE=1 SV=1 O43150|ASAP2_HUMAN Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens GN=AS Q01518|CAP1_HUMAN Adenylyl cyclase-associated protein 1 OS=Homo sapiens GN=CAP1 PE=1 SV=4 Q8TER0|SNED1_HUMAN Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens GN=SNED1 PE=1 SV=2 P60903|S10AA_HUMAN Protein S100-A10 OS=Homo sapiens GN=S100A10 PE=1 SV=2 P68871|HBB_HUMAN Hemoglobin subunit beta OS=Homo sapiens GN=HBB PE=1 SV=2 P06702|S10A9_HUMAN Protein S100-A9 OS=Homo sapiens GN=S100A9 PE=1 SV=1 P53396|ACLY_HUMAN ATP-citrate synthase OS=Homo sapiens GN=ACLY PE=1 SV=3 Q96C19|EFHD2_HUMAN EF-hand domain-containing protein D2 OS=Homo sapiens GN=EFHD2 PE=1 SV=1 P78417|GSTO1_HUMAN Glutathione S-transferase omega-1 OS=Homo sapiens GN=GSTO1 PE=1 SV=2 P63244|GBLP_HUMAN Guanine nucleotide-binding protein subunit beta-2-like 1 OS=Homo sapiens GN=GNB2L1 PE=1 SV=3 Q9BRF8|CPPED_HUMAN Calcineurin-like phosphoesterase domain-containing protein 1 OS=Homo sapiens GN=CPPED1 PE=1 P68366|TBA4A_HUMAN Tubulin alpha-4A chain OS=Homo sapiens GN=TUBA4A PE=1 SV=1 P12814|ACTN1_HUMAN Alpha-actinin-1 OS=Homo sapiens GN=ACTN1 PE=1 SV=2 Q99497|PARK7_HUMAN Protein DJ-1 OS=Homo sapiens GN=PARK7 PE=1 SV=2 P61088|UBE2N_HUMAN Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens GN=UBE2N PE=1 SV=1 P35579|MYH9_HUMAN Myosin-9 OS=Homo sapiens GN=MYH9 PE=1 SV=4 P09211|GSTP1_HUMAN Glutathione S-transferase P OS=Homo sapiens GN=GSTP1 PE=1 SV=2 P50395|GDIB_HUMAN Rab GDP dissociation inhibitor beta OS=Homo sapiens GN=GDI2 PE=1 SV=2 P29350|PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens GN=PTPN6 PE=1 SV=1 P48643|TCPE_HUMAN T-complex protein 1 subunit epsilon OS=Homo sapiens GN=CCT5 PE=1 SV=1 P25788|PSA3_HUMAN Proteasome subunit alpha type-3 OS=Homo sapiens GN=PSMA3 PE=1 SV=2 P07437|TBB5_HUMAN Tubulin beta chain OS=Homo sapiens GN=TUBB PE=1 SV=2 P61769|B2MG_HUMAN Beta-2-microglobulin OS=Homo sapiens GN=B2M PE=1 SV=1 Q00610|CLH1_HUMAN Clathrin heavy chain 1 OS=Homo sapiens GN=CLTC PE=1 SV=5 P13489|RINI_HUMAN Ribonuclease inhibitor OS=Homo sapiens GN=RNH1 PE=1 SV=2 P63218|GBG5_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens GN=GNG5 PE P55072|TERA_HUMAN Transitional endoplasmic reticulum ATPase OS=Homo sapiens GN=VCP PE=1 SV=4 Q15149|PLEC1_HUMAN -1 OS=Homo sapiens GN=PLEC1 PE=1 SV=3 P07602|SAP_HUMAN Proactivator polypeptide OS=Homo sapiens GN=PSAP PE=1 SV=2 Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 OS=Homo sapiens GN=CDC37 PE=1 SV=1 Q99832|TCPH_HUMAN T-complex protein 1 subunit eta OS=Homo sapiens GN=CCT7 PE=1 SV=2 Q14210|LY6D_HUMAN Lymphocyte antigen 6D OS=Homo sapiens GN=LY6D PE=1 SV=1 P25789|PSA4_HUMAN Proteasome subunit alpha type-4 OS=Homo sapiens GN=PSMA4 PE=1 SV=1 P15144|AMPN_HUMAN Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 P62826|RAN_HUMAN GTP-binding nuclear protein Ran OS=Homo sapiens GN=RAN PE=1 SV=3

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P22392|NDKB_HUMAN Nucleoside diphosphate kinase B OS=Homo sapiens GN=NME2 PE=1 SV=1 P06744|G6PI_HUMAN Glucose-6-phosphate isomerase OS=Homo sapiens GN=GPI PE=1 SV=4 P11413|G6PD_HUMAN Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens GN=G6PD PE=1 SV=4 P02654|APOC1_HUMAN Apolipoprotein C-I OS=Homo sapiens GN=APOC1 PE=1 SV=1 Q08554|DSC1_HUMAN Desmocollin-1 OS=Homo sapiens GN=DSC1 PE=1 SV=2 P28072|PSB6_HUMAN Proteasome subunit beta type-6 OS=Homo sapiens GN=PSMB6 PE=1 SV=4 P62913|RL11_HUMAN 60S ribosomal protein L11 OS=Homo sapiens GN=RPL11 PE=1 SV=2 P35580|MYH10_HUMAN Myosin-10 OS=Homo sapiens GN=MYH10 PE=1 SV=3 Q7Z406|MYH14_HUMAN Myosin-14 OS=Homo sapiens GN=MYH14 PE=1 SV=1 P08865|RSSA_HUMAN 40S ribosomal protein SA OS=Homo sapiens GN=RPSA PE=1 SV=4 O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens GN=IDH1 PE=1 SV=2 P30050|RL12_HUMAN 60S ribosomal protein L12 OS=Homo sapiens GN=RPL12 PE=1 SV=1 Q8TCU5|NMD3A_HUMAN Glutamate [NMDA] receptor subunit 3A OS=Homo sapiens GN=GRIN3A PE=1 SV=2 P09496|CLCA_HUMAN Clathrin light chain A OS=Homo sapiens GN=CLTA PE=1 SV=1 O00175|CCL24_HUMAN C-C motif chemokine 24 OS=Homo sapiens GN=CCL24 PE=1 SV=2 P29508|SPB3_HUMAN Serpin B3 OS=Homo sapiens GN=SERPINB3 PE=1 SV=2 O60234|GMFG_HUMAN Glia maturation factor gamma OS=Homo sapiens GN=GMFG PE=1 SV=1 P06899|H2B1J_HUMAN Histone H2B type 1-J OS=Homo sapiens GN=HIST1H2BJ PE=1 SV=3 Q15942|ZYX_HUMAN Zyxin OS=Homo sapiens GN=ZYX PE=1 SV=1 P15121|ALDR_HUMAN Aldose reductase OS=Homo sapiens GN=AKR1B1 PE=1 SV=3 P15104|GLNA_HUMAN Glutamine synthetase OS=Homo sapiens GN=GLUL PE=1 SV=4 O15078|CE290_HUMAN Centrosomal protein of 290 kDa OS=Homo sapiens GN=CEP290 PE=1 SV=2 Q5TZA2|CROCC_HUMAN Rootletin OS=Homo sapiens GN=CROCC PE=1 SV=1 Q9UNF0|PACN2_HUMAN Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens GN=PACSIN2 P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 OS=Homo sapiens GN=PDIA3 PE=1 SV=4 P22314|UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3 P08571|CD14_HUMAN Monocyte differentiation antigen CD14 OS=Homo sapiens GN=CD14 PE=1 SV=2 O00182|LEG9_HUMAN Galectin-9 OS=Homo sapiens GN=LGALS9 PE=1 SV=2 P01034|CYTC_HUMAN Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1 O60437|PEPL_HUMAN OS=Homo sapiens GN=PPL PE=1 SV=3 P15880|RS2_HUMAN 40S ribosomal protein S2 OS=Homo sapiens GN=RPS2 PE=1 SV=2 P84098|RL19_HUMAN 60S ribosomal protein L19 OS=Homo sapiens GN=RPL19 PE=1 SV=1 P02788|TRFL_HUMAN Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 O75635|SPB7_HUMAN Serpin B7 OS=Homo sapiens GN=SERPINB7 PE=2 SV=1 P01023|A2MG_HUMAN Alpha-2-macroglobulin OS=Homo sapiens GN=A2M PE=1 SV=2 P51153|RAB13_HUMAN Ras-related protein Rab-13 OS=Homo sapiens GN=RAB13 PE=1 SV=1 P62820|RAB1A_HUMAN Ras-related protein Rab-1A OS=Homo sapiens GN=RAB1A PE=1 SV=3 Q9P1U1|ARP3B_HUMAN Actin-related protein 3B OS=Homo sapiens GN=ACTR3B PE=1 SV=1 P01857|IGHG1_HUMAN Ig gamma-1 chain C region OS=Homo sapiens GN=IGHG1 PE=1 SV=1 P99999|CYC_HUMAN Cytochrome c OS=Homo sapiens GN=CYCS PE=1 SV=2 Q9P2D7|DYH1_HUMAN heavy chain 1, axonemal OS=Homo sapiens GN=DNAH1 PE=1 SV=3 Q15582|BGH3_HUMAN Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens GN=TGFBI PE=1 SV=1 P61224|RAP1B_HUMAN Ras-related protein Rap-1b OS=Homo sapiens GN=RAP1B PE=1 SV=1 P60866|RS20_HUMAN 40S ribosomal protein S20 OS=Homo sapiens GN=RPS20 PE=1 SV=1 O14818|PSA7_HUMAN Proteasome subunit alpha type-7 OS=Homo sapiens GN=PSMA7 PE=1 SV=1 P60900|PSA6_HUMAN Proteasome subunit alpha type-6 OS=Homo sapiens GN=PSMA6 PE=1 SV=1 Q5TFQ8|SIRBL_HUMAN Signal-regulatory protein beta-1 isoform 3 OS=Homo sapiens GN=SIRPB1 PE=1 SV=1 P01876|IGHA1_HUMAN Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 P25398|RS12_HUMAN 40S ribosomal protein S12 OS=Homo sapiens GN=RPS12 PE=1 SV=3 P12955|PEPD_HUMAN Xaa-Pro dipeptidase OS=Homo sapiens GN=PEPD PE=1 SV=3 P49773|HINT1_HUMAN Histidine triad nucleotide-binding protein 1 OS=Homo sapiens GN=HINT1 PE=1 SV=2 O00626|CCL22_HUMAN C-C motif chemokine 22 OS=Homo sapiens GN=CCL22 PE=1 SV=1 Q9H3K6|BOLA2_HUMAN BolA-like protein 2 OS=Homo sapiens GN=BOLA2 PE=1 SV=1 Q9HC38|GLOD4_HUMAN Glyoxalase domain-containing protein 4 OS=Homo sapiens GN=GLOD4 PE=1 SV=1 Q15121|PEA15_HUMAN Astrocytic phosphoprotein PEA-15 OS=Homo sapiens GN=PEA15 PE=1 SV=2 P30086|PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens GN=PEBP1 PE=1 SV=3 P22061|PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=1 SV=3 P50990|TCPQ_HUMAN T-complex protein 1 subunit theta OS=Homo sapiens GN=CCT8 PE=1 SV=4 P05089|ARGI1_HUMAN Arginase-1 OS=Homo sapiens GN=ARG1 PE=1 SV=2 Q8WVV4|POF1B_HUMAN Protein POF1B OS=Homo sapiens GN=POF1B PE=1 SV=2 P28062|PSB8_HUMAN Proteasome subunit beta type-8 OS=Homo sapiens GN=PSMB8 PE=1 SV=2 P15090|FABP4_HUMAN Fatty acid-binding protein, adipocyte OS=Homo sapiens GN=FABP4 PE=1 SV=3 P17900|SAP3_HUMAN Ganglioside GM2 activator OS=Homo sapiens GN=GM2A PE=1 SV=4 P02792|FRIL_HUMAN Ferritin light chain OS=Homo sapiens GN=FTL PE=1 SV=2 P0C0S5|H2AZ_HUMAN Histone H2A.Z OS=Homo sapiens GN=H2AFZ PE=1 SV=2 P30041|PRDX6_HUMAN Peroxiredoxin-6 OS=Homo sapiens GN=PRDX6 PE=1 SV=3 P38606|VATA_HUMAN V-type proton ATPase catalytic subunit A OS=Homo sapiens GN=ATP6V1A PE=1 SV=2 Q96PE2|ARHGH_HUMAN Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 P62906|RL10A_HUMAN 60S ribosomal protein L10a OS=Homo sapiens GN=RPL10A PE=1 SV=2 P14324|FPPS_HUMAN Farnesyl pyrophosphate synthetase OS=Homo sapiens GN=FDPS PE=1 SV=4 Q14315|FLNC_HUMAN Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 Q8WZ42|TITIN_HUMAN OS=Homo sapiens GN=TTN PE=1 SV=2 P30153|2AAA_HUMAN Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sa Q14847|LASP1_HUMAN LIM and SH3 domain protein 1 OS=Homo sapiens GN=LASP1 PE=1 SV=2 P47755|CAZA2_HUMAN F-actin-capping protein subunit alpha-2 OS=Homo sapiens GN=CAPZA2 PE=1 SV=3 P55854|SUMO3_HUMAN Small ubiquitin-related modifier 3 OS=Homo sapiens GN=SUMO3 PE=1 SV=2 P04040|CATA_HUMAN Catalase OS=Homo sapiens GN=CAT PE=1 SV=3 Q86WR0|CCD25_HUMAN Coiled-coil domain-containing protein 25 OS=Homo sapiens GN=CCDC25 PE=1 SV=2 Q9UPR0|PLCL2_HUMAN Inactive phospholipase C-like protein 2 OS=Homo sapiens GN=PLCL2 PE=1 SV=2 Q6ZR08|DYH12_HUMAN Dynein heavy chain 12, axonemal OS=Homo sapiens GN=DNAH12 PE=2 SV=2 P53675|CLH2_HUMAN Clathrin heavy chain 2 OS=Homo sapiens GN=CLTCL1 PE=1 SV=2 P30740|ILEU_HUMAN Leukocyte elastase inhibitor OS=Homo sapiens GN=SERPINB1 PE=1 SV=1 P28066|PSA5_HUMAN Proteasome subunit alpha type-5 OS=Homo sapiens GN=PSMA5 PE=1 SV=3 Q9Y4G6|TLN2_HUMAN Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 P59665|DEF1_HUMAN Neutrophil defensin 1 OS=Homo sapiens GN=DEFA1 PE=1 SV=1 P61916|NPC2_HUMAN Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 O43776|SYNC_HUMAN Asparaginyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=NARS PE=1 SV=1 P62993|GRB2_HUMAN Growth factor receptor-bound protein 2 OS=Homo sapiens GN=GRB2 PE=1 SV=1 Q6NSJ5|LRC8E_HUMAN Leucine-rich repeat-containing protein 8E OS=Homo sapiens GN=LRRC8E PE=2 SV=1

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Q92889|XPF_HUMAN DNA repair endonuclease XPF OS=Homo sapiens GN=ERCC4 PE=1 SV=3 P40926|MDHM_HUMAN Malate dehydrogenase, mitochondrial OS=Homo sapiens GN=MDH2 PE=1 SV=3 O00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens GN=PDE2A PE=1 SV=1 P58107|EPIPL_HUMAN Epiplakin OS=Homo sapiens GN=EPPK1 PE=1 SV=1 P59998|ARPC4_HUMAN Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens GN=ARPC4 PE=1 SV=3 Q92598|HS105_HUMAN Heat shock protein 105 kDa OS=Homo sapiens GN=HSPH1 PE=1 SV=1 Q14240|IF4A2_HUMAN Eukaryotic initiation factor 4A-II OS=Homo sapiens GN=EIF4A2 PE=1 SV=2 Q6ZN18|AEBP2_HUMAN Zinc finger protein AEBP2 OS=Homo sapiens GN=AEBP2 PE=1 SV=2 P21281|VATB2_HUMAN V-type proton ATPase subunit B, brain isoform OS=Homo sapiens GN=ATP6V1B2 PE=1 SV=3 O43707|ACTN4_HUMAN Alpha-actinin-4 OS=Homo sapiens GN=ACTN4 PE=1 SV=2 P28838|AMPL_HUMAN Cytosol aminopeptidase OS=Homo sapiens GN=LAP3 PE=1 SV=3 P06454|PTMA_HUMAN Prothymosin alpha OS=Homo sapiens GN=PTMA PE=1 SV=2 Q13835|PKP1_HUMAN -1 OS=Homo sapiens GN=PKP1 PE=1 SV=2 Q86VP6|CAND1_HUMAN Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens GN=CAND1 PE=1 SV=2 Q8N335|GPD1L_HUMAN Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens GN=GPD1L PE=1 SV=1 Q09666|AHNK_HUMAN Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens GN=AHNAK PE=1 SV=2 P12532|KCRU_HUMAN Creatine kinase U-type, mitochondrial OS=Homo sapiens GN=CKMT1A PE=1 SV=1 P61247|RS3A_HUMAN 40S ribosomal protein S3a OS=Homo sapiens GN=RPS3A PE=1 SV=2 O94788|AL1A2_HUMAN Retinal dehydrogenase 2 OS=Homo sapiens GN=ALDH1A2 PE=1 SV=3 P00352|AL1A1_HUMAN Retinal dehydrogenase 1 OS=Homo sapiens GN=ALDH1A1 PE=1 SV=2 Q5JNZ5|RS26L_HUMAN Putative 40S ribosomal protein S26-like 1 OS=Homo sapiens GN=RPS26P11 PE=5 SV=1 P02545|LMNA_HUMAN -A/C OS=Homo sapiens GN=LMNA PE=1 SV=1 Q11203|SIAT6_HUMAN CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase OS=Homo sapiens GN= A4D0S4|LAMB4_HUMAN Laminin subunit beta-4 OS=Homo sapiens GN=LAMB4 PE=2 SV=1 P49720|PSB3_HUMAN Proteasome subunit beta type-3 OS=Homo sapiens GN=PSMB3 PE=1 SV=2 O95336|6PGL_HUMAN 6-phosphogluconolactonase OS=Homo sapiens GN=PGLS PE=1 SV=2 P30046|DOPD_HUMAN D-dopachrome decarboxylase OS=Homo sapiens GN=DDT PE=1 SV=3 P25786|PSA1_HUMAN Proteasome subunit alpha type-1 OS=Homo sapiens GN=PSMA1 PE=1 SV=1 P55060|XPO2_HUMAN Exportin-2 OS=Homo sapiens GN=CSE1L PE=1 SV=3 Q9ULV4|COR1C_HUMAN Coronin-1C OS=Homo sapiens GN=CORO1C PE=1 SV=1 P22304|IDS_HUMAN Iduronate 2-sulfatase OS=Homo sapiens GN=IDS PE=1 SV=1 P62269|RS18_HUMAN 40S ribosomal protein S18 OS=Homo sapiens GN=RPS18 PE=1 SV=3 P46781|RS9_HUMAN 40S ribosomal protein S9 OS=Homo sapiens GN=RPS9 PE=1 SV=3 Q8NB37|PDDC1_HUMAN Parkinson disease 7 domain-containing protein 1 OS=Homo sapiens GN=PDDC1 PE=1 SV=1 P16949|STMN1_HUMAN OS=Homo sapiens GN=STMN1 PE=1 SV=3 Q8NEZ4|MLL3_HUMAN Histone-lysine N-methyltransferase MLL3 OS=Homo sapiens GN=MLL3 PE=1 SV=3 Q01968|OCRL_HUMAN Inositol polyphosphate 5-phosphatase OCRL-1 OS=Homo sapiens GN=OCRL PE=1 SV=3 O14523|C2C2L_HUMAN C2 domain-containing protein 2-like OS=Homo sapiens GN=C2CD2L PE=1 SV=3 Q96KP4|CNDP2_HUMAN Cytosolic non-specific dipeptidase OS=Homo sapiens GN=CNDP2 PE=1 SV=2 Q63HK5|TSH3_HUMAN Teashirt homolog 3 OS=Homo sapiens GN=TSHZ3 PE=1 SV=2

Select Summary Report

Format As Select Summary (protein hits) Help Significance threshold p< 0.05 Max. number of hits AUTO Standard scoring %$#"! MudPIT scoring %$#"! Ions score or expect cut-off 0 Show sub-sets 0 Show pop-ups %$#"! Suppress pop-ups %$#"! Sort unassigned Decreasing Score Require bold red 

1. P13645|K1C10_HUMAN Mass: 59020 Score: 7634 Queries matched: 412 emPAI: 2.61 Keratin, type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1710 404.1961 806.3776 806.3923 -0.0146 0 55 0.00018 1 R.LAADDFR.L 64 65 1700 1701 1702 1703 1704 1705 1706 1707 1708 1860 405.2101 808.4057 808.4330 -0.0273 0 47 0.001 1 R.LASYLDK.V 1859 1861 1863 1864 1865 1866 1867 1868 1869 1870 3748 424.2300 846.4455 846.4447 0.0009 0 49 0.00092 1 K.SEITELR.R 3723 3724 3725 3726 3727 3728 3729 3730 3731 3732 8076 497.2479 992.4813 992.4927 -0.0114 0 63 3.1e-005 1 K.YENEVALR.Q 8053 8054 8055 8056 8057 8058 8059 8060 8061 8062 8102 498.2580 994.5014 994.5123 -0.0110 1 36 0.011 1 K.IKEWYEK.H 8094 8095 8096 8097 8098 8099 8100 8101 8103 8104 8350 502.2723 1002.5301 1002.5458 -0.0157 1 28 0.1 1 K.SEITELRR.N 8337 8338 8339 8340 8341 8342 8343 8344 8345 8348 8920 516.2953 1030.5760 1030.5910 -0.0151 0 36 0.014 1 R.VLDELTLTK.A 8916 1330 1334 9818 532.8017 1063.5889 1063.6026 -0.0137 1 60 5.6e-005 1 R.LASYLDKVR.A 9810 9811 9812 9813 9814 9816 9817 10410 545.7462 1089.4778 1089.5237 -0.0458 0 (64) 2.3e-005 1 K.VTMQNLNDR.L 10411 10412 10413 10414 10415 10416 10417 10418 10624 553.7548 1105.4951 1105.5186 -0.0235 0 66 1.6e-005 1 K.VTMQNLNDR.L 10616 10617 10618 1418 10619 10620 10621 10622 10778 555.2368 1108.4591 1108.4825 -0.0234 0 64 1.7e-005 1 K.DAEAWFNEK.S 10768 10769 10770 10771 10772 10773 10774 10775 11754 583.2807 1164.5468 1164.5775 -0.0307 0 74 1.9e-006 1 R.LENEIQTYR.S 11750 11751 11752 11753 11755 11756 11757 1467 12322 601.3055 1200.5964 1200.6098 -0.0134 0 66 1.4e-005 1 R.QSVEADINGLR.R 12747 617.8239 1233.6333 1233.6717 -0.0384 1 50 0.00054 1 R.LKYENEVALR.Q 12745 12746 12748 12788 413.2022 1236.5848 1236.5775 0.0073 1 29 0.058 1 R.KDAEAWFNEK.S 13122 631.7898 1261.5650 1261.5899 -0.0249 0 95 1.6e-008 1 R.SLLEGEGSSGGGGR.G 13104 13105 13106 13107 13109 13110 13111 13535 434.2037 1299.5892 1299.5877 0.0014 1 (16) 1.2 1 K.NHEEEMKDLR.N 13719 439.5332 1315.5777 1315.5826 -0.0050 1 40 0.0054 1 K.NHEEEMKDLR.N 13718 13720 13721 14086 453.2367 1356.6882 1356.7110 -0.0228 1 14 1.9 1 R.QSVEADINGLRR.V 14083 14085 14119 683.2945 1364.5744 1364.6320 -0.0576 0 91 3.8e-008 1 R.SQYEQLAEQNR.K 14118 14120 14121 14122 14123 14124 14125 141 14237 691.3093 1380.6039 1380.6408 -0.0369 0 101 3.9e-009 1 R.ALEESNYELEGK.I 14228 14229 14230 14231 14232 14233 14234 14 14311 695.8351 1389.6557 1389.6736 -0.0179 0 82 3e-007 1 K.QSLEASLAETEGR.Y 14310 14554 478.9243 1433.7510 1433.7626 -0.0117 1 9 6.2 1 K.IRLENEIQTYR.S 14856 498.5801 1492.7186 1492.7270 -0.0084 1 49 0.00062 1 R.SQYEQLAEQNRK.D 14828 14829 14830 14832 14833 14834 14835 14 15032 775.3315 1548.6485 1548.6700 -0.0215 0 129 4.5e-012 1 R.SGGGGGGGGCGGGGGVSSLR.I

2. P04264|K2C1_HUMAN Mass: 66170 Score: 7414 Queries matched: 412 emPAI: 3.88 Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2599 416.7370 831.4594 831.4814 -0.0220 0 56 0.00019 1 K.SISISVAR.G 2587 2589 2590 2591 2592 2593 2595 2596 2597 2598 5269 437.7490 873.4835 873.4920 -0.0085 0 63 4.1e-005 1 R.SLVNLGGSK.S 5238 5239 5240 5241 5242 5243 5244 5245 5246 524 6842 466.7493 931.4841 931.4974 -0.0133 1 33 0.028 1 R.SEIDNVKK.Q 6840 7608 487.2601 972.5056 972.5240 -0.0184 0 55 0.00022 1 K.IEISELNR.V 7595 7596 7597 7598 7599 7600 7601 7602 7603 7604 8136 500.2212 998.4278 998.4379 -0.0101 0 55 0.00015 1 K.DVDGAYMTK.V 8133 8134 1252 8135 8137 8138 8139 8140

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8453 503.7473 1005.4801 1005.4224 0.0577 0 9 7.8 3 R.GGSGGGGGGSSGGR.G 8444 8452 8529 508.2208 1014.4270 1014.4328 -0.0058 0 (33) 0.029 1 K.DVDGAYMTK.V 8525 8526 8527 8528 8530 8977 517.2539 1032.4933 1032.5087 -0.0155 0 56 0.00016 1 R.TLLEGEESR.M 8959 8960 8961 8962 8964 8965 8966 8967 8968 89 9848 533.2551 1064.4957 1064.5138 -0.0181 0 63 2.8e-005 1 K.AQYEDIAQK.S 9822 9826 9827 9832 9834 9835 9836 9838 9839 984 9893 533.7607 1065.5069 1065.5090 -0.0021 1 49 0.00065 1 K.YEDEINKR.T 9885 9886 9888 9889 9890 9891 10055 537.2991 1072.5836 1072.5876 -0.0040 1 32 0.036 1 R.LRSEIDNVK.K 10012 10025 11088 563.2688 1124.5231 1124.5349 -0.0118 0 73 2.6e-006 1 K.AEAESLYQSK.Y 11061 11062 11063 11064 11065 11066 11067 110 11114 564.2644 1126.5143 1126.5329 -0.0185 1 61 4.2e-005 1 K.KDVDGAYMTK.V 11415 571.2554 1140.4962 1140.5121 -0.0159 0 (34) 0.018 1 R.DYQELMNTK.L 11411 11458 572.2705 1142.5264 1142.5278 -0.0013 1 (19) 0.71 1 K.KDVDGAYMTK.V 11596 576.7709 1151.5273 1151.5458 -0.0185 1 41 0.0042 1 R.NKYEDEINK.R 11594 11605 579.2554 1156.4961 1156.5070 -0.0109 0 48 0.00071 1 R.DYQELMNTK.L 11606 12026 590.2986 1178.5827 1178.5931 -0.0104 0 87 9.9e-008 1 K.YEELQITAGR.H 12000 12001 12002 12003 12004 12005 12006 1200 13170 633.3152 1264.6158 1264.6299 -0.0141 0 93 2.2e-008 1 R.TNAENEFVTIK.K 13145 13146 13147 13148 13149 13150 13151 131 13534 650.7611 1299.5076 1299.5224 -0.0148 0 59 4.1e-005 1 K.NMQDMVEDYR.N 13556 651.8525 1301.6905 1301.7078 -0.0173 0 87 8.6e-008 1 R.SLDLDSIIAEVK.A 13717 658.7518 1315.4890 1315.5173 -0.0283 0 (48) 0.00056 1 K.NMQDMVEDYR.N 13811 666.7376 1331.4606 1331.5122 -0.0515 0 (34) 0.0072 1 K.NMQDMVEDYR.N 13919 670.8299 1339.6453 1339.6619 -0.0166 1 84 2e-007 1 K.SKAEAESLYQSK.Y 13898 13899 13900 13901 13902 13903 13904 13 14084 679.3421 1356.6696 1356.6885 -0.0189 0 73 2.3e-006 1 K.LNDLEDALQQAK.E 14280 692.3561 1382.6977 1382.6830 0.0147 0 70 5.2e-006 1 K.SLNNQFASFIDK.V 1533 14346 465.2432 1392.7077 1392.7249 -0.0172 1 72 3e-006 1 R.TNAENEFVTIKK.D 14322 14324 14325 14326 14327 14328 14329 14 14723 738.3611 1474.7077 1474.7416 -0.0339 0 54 0.00018 1 K.WELLQQVDTSTR.T 14748 738.3871 1474.7595 1474.7780 -0.0184 0 97 8.1e-009 1 R.FLEQQNQVLQTK.W 14722 14725 14726 14727 14728 14729 14730 14 15156 829.3807 1656.7468 1656.7856 -0.0388 0 85 1.2e-007 1 R.SGGGFSSGSAGIINYQR.R

3. P35908|K22E_HUMAN Mass: 65678 Score: 6001 Queries matched: 315 emPAI: 1.84 Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 274 414.2153 826.4159 826.4225 -0.0066 0 36 0.024 1 K.FASFIDK.V 2405 2406 270 2408 2410 2411 2412 2413 2414 2415 2 2573 416.2472 830.4798 830.4862 -0.0063 0 56 0.00018 1 R.SLVGLGGTK.S 2545 2546 2547 2548 2549 2550 2551 2552 2553 255 7608 487.2601 972.5056 972.5240 -0.0184 0 55 0.00022 1 K.IEISELNR.V 7595 7596 7597 7598 7599 7600 7601 7602 7603 7604 8090 497.7673 993.5200 993.5607 -0.0407 0 54 0.00019 1 R.LQGEIAHVK.K 8089 8091 8092 8093 8412 503.2351 1004.4556 1004.4597 -0.0041 0 58 0.0001 1 K.LLEGEECR.M 8396 8397 8398 8399 8400 8401 8402 8403 8404 8405 8504 507.2990 1012.5835 1012.4140 0.1695 0 7 9.6 2 -.MSCQISCK.S 9070 519.2591 1036.5037 1036.5189 -0.0152 0 53 0.00023 1 R.YLDGLTAER.T 1343 9063 9064 9065 9066 9067 9068 9069 9071 907 9136 521.2749 1040.5352 1040.5502 -0.0150 0 1 42 2 K.VDPEIQNVK.A 9893 533.7607 1065.5069 1065.5090 -0.0021 1 49 0.00065 1 K.YEDEINKR.T 9885 9886 9888 9889 9890 9891 9898 534.7510 1067.4875 1067.4957 -0.0082 0 27 0.09 1 K.DVDNAYMIK.V 10743 554.2662 1106.5178 1106.5356 -0.0178 0 68 8.9e-006 1 K.AQYEEIAQR.S 10724 10725 10727 10728 10729 10730 10731 10733 10987 561.8143 1121.6141 1121.6557 -0.0416 1 10 5.4 2 R.LQGEIAHVKK.Q 11194 566.2561 1130.4976 1130.5026 -0.0051 0 55 0.00015 1 R.STSSFSCLSR.H 11174 11175 11176 11177 11178 11179 11180 1118 11226 567.2803 1132.5460 1132.5546 -0.0086 1 62 3.6e-005 1 R.KLLEGEECR.M 11222 11379 570.3302 1138.6459 1138.5328 0.1131 0 12 3 4 R.DYQELMNVK.L 12286 599.2905 1196.5664 1196.5422 0.0242 0 70 5.1e-006 1 K.GGSISGGGYGSGGGK.H 12260 12261 12262 12263 12264 12265 1226 12446 604.8036 1207.5926 1207.6085 -0.0158 0 71 4e-006 1 R.TAAENDFVTLK.K 12436 12437 12438 12439 12440 12442 12443 124 13006 627.7952 1253.5759 1253.6001 -0.0241 0 107 9e-010 1 R.GFSSGSAVVSGGSR.R 12991 12992 12993 12994 12995 12996 12997 13809 665.3093 1328.6040 1328.6320 -0.0280 0 41 0.0041 1 K.NVQDAIADAEQR.G 13836 446.2356 1335.6850 1335.7034 -0.0184 1 46 0.0012 1 R.TAAENDFVTLKK.D 13827 13828 13829 13830 13831 13832 13833 13 14318 464.5574 1390.6504 1390.6728 -0.0224 1 53 0.00025 1 R.SKEEAEALYHSK.Y 14313 14314 14315 14316 14317 14319 14748 738.3871 1474.7595 1474.7780 -0.0184 0 97 8.1e-009 1 R.FLEQQNQVLQTK.W 14722 14723 14725 14726 14727 14728 14729 14 15086 794.8380 1587.6615 1587.6761 -0.0146 0 89 4.2e-008 1 R.GGSSSGGGYGSGGGGSSSVK.G 15188 870.8391 1739.6636 1739.6983 -0.0347 0 129 2.2e-012 1 R.GSSSGGGYSSGSSSYGSGGR.Q

4. P35527|K1C9_HUMAN Mass: 62255 Score: 5749 Queries matched: 253 emPAI: 1.39 Keratin, type I cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1860 405.2101 808.4057 808.4330 -0.0273 0 47 0.001 1 R.LASYLDK.V 1859 1861 1863 1864 1865 1866 1867 1868 1869 1870 5875 449.1993 896.3840 896.4062 -0.0222 0 41 0.0034 1 R.MTLDDFR.I 5880 6333 457.2036 912.3927 912.4011 -0.0084 0 (33) 0.025 1 R.MTLDDFR.I 6317 6318 6319 6320 6321 6322 6323 6324 6325 6326 7523 484.2310 966.4475 966.4447 0.0028 0 28 0.074 1 K.IQDWYDK.K 7520 7521 7522 9660 530.7717 1059.5288 1059.5560 -0.0272 0 54 0.00027 1 K.TLLDIDNTR.M 9648 9649 9650 9651 9652 9653 9654 9655 9657 965 9824 533.2443 1064.4740 1064.4920 -0.0180 0 (55) 0.00017 1 K.STMQELNSR.L 9821 9823 9825 9828 9829 9830 9831 1375 9837 984 9893 533.7607 1065.5069 1065.4913 0.0156 0 8 7.8 8 K.FEMEQNLR.Q 9886 9888 9889 9890 9891 10058 537.7559 1073.4973 1073.5142 -0.0168 0 8 10 2 R.QFSSSYLSR.S 10224 541.2440 1080.4734 1080.4870 -0.0135 0 57 0.00011 1 K.STMQELNSR.L 10225 10954 561.2855 1120.5564 1120.5764 -0.0200 0 56 0.00015 1 R.QEYEQLIAK.N 10945 10946 10950 10951 10952 10953 10958 1095 11629 579.2926 1156.5706 1156.5836 -0.0131 0 86 1.3e-007 1 R.QGVDADINGLR.Q 11607 11609 11610 11611 11613 11614 11618 11 12098 595.8004 1189.5863 1189.6013 -0.0149 0 (54) 0.00023 1 R.QVLDNLTMEK.S 12100 12412 603.7978 1205.5810 1205.5962 -0.0152 0 65 1.6e-005 1 R.QVLDNLTMEK.S 12399 12401 12402 12403 12404 12405 12406 1491 12728 616.7958 1231.5771 1231.5906 -0.0135 0 111 3.9e-010 1 R.SGGGGGGGLGSGGSIR.S 12700 12701 12702 12703 12704 12705 127 12764 618.2550 1234.4954 1234.5215 -0.0261 0 105 1.5e-009 1 R.FSSSSGYGGGSSR.V 1507 12750 12751 12752 12753 12754 12755 12 13745 441.8872 1322.6398 1322.6652 -0.0254 1 23 0.23 1 R.IKFEMEQNLR.Q 13746 15084 793.8654 1585.7163 1585.7583 -0.0420 0 88 6.3e-008 1 K.VQALEEANNDLENK.I 15083 15212 896.3336 1790.6526 1790.7205 -0.0679 0 111 1.2e-010 1 R.GGSGGSYGGGGSGGGYGGGSGSR.G 15213 15214

5. P02533|K1C14_HUMAN Mass: 51872 Score: 4189 Queries matched: 232 emPAI: 1.47 Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1710 404.1961 806.3776 806.3923 -0.0146 0 55 0.00018 1 R.LAADDFR.T 64 65 1700 1701 1702 1703 1704 1705 1706 1707 1708 1860 405.2101 808.4057 808.4330 -0.0273 0 47 0.001 1 R.LASYLDK.V 1859 1861 1863 1864 1865 1866 1867 1868 1869 1870 2636 417.2104 832.4063 832.4290 -0.0227 0 30 0.065 1 K.SEISELR.R 6541 460.2102 918.4057 918.4123 -0.0066 0 21 0.52 1 K.DYSPYFK.T 6540 6542 7990 495.2598 988.5050 988.5301 -0.0252 1 28 0.1 1 K.SEISELRR.T 7984 7985 7986 7992 7993 7996 1319 515.2978 1028.5810 1028.5866 -0.0056 0 44 0.0081 1 R.VLDELTLAR.A 1308 8862 8882 1313 1315 1316 1317 8902 1320 9059 518.7686 1035.5227 1035.5250 -0.0022 1 14 2.1 1 K.IRDWYQR.Q 9818 532.8017 1063.5889 1063.6026 -0.0137 1 60 5.6e-005 1 R.LASYLDKVR.A 9810 9811 9812 9813 9814 9816 9817

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10410 545.7462 1089.4778 1089.5237 -0.0458 0 (64) 2.3e-005 1 K.VTMQNLNDR.L 10411 10412 10413 10414 10415 10416 10417 10418 10624 553.7548 1105.4951 1105.5186 -0.0235 0 66 1.6e-005 1 K.VTMQNLNDR.L 10616 10617 10618 1418 10619 10620 10621 10622 10655 553.7800 1105.5454 1105.5550 -0.0096 0 77 1.1e-006 1 R.ISSVLAGGSCR.A 10632 10646 10647 10648 10650 10651 10652 10 11605 579.2554 1156.4961 1156.5070 -0.0109 1 1 37 10 R.DQYEKMAEK.N 11799 584.3429 1166.6713 1166.6408 0.0306 0 3 25 1 K.VVSTHEQVLR.T 11839 586.7608 1171.5070 1171.5186 -0.0115 0 57 9.9e-005 1 K.DAEEWFFTK.T 1482 593.2833 1184.5520 1184.6877 -0.1357 1 5 46 4 R.RVLDELTLAR.A 12552 610.7985 1219.5824 1219.5932 -0.0108 0 72 3.1e-006 1 K.ASLENSLEETK.G 12548 12550 12551 13303 639.7903 1277.5660 1277.5783 -0.0123 0 89 6e-008 1 K.GSCGIGGGIGGGSSR.I 13296 13297 13298 13299 13300 13301 1330 13550 651.3254 1300.6363 1300.6510 -0.0147 0 96 1.2e-008 1 R.ALEEANADLEVK.I 13536 13537 13539 13540 13541 13542 13543 13 14102 681.3307 1360.6469 1360.6834 -0.0365 0 101 4.3e-009 1 R.EVATNSELVQSGK.S 14097 14098 14099 14100 14101 14103 14104 1 14515 713.3183 1424.6221 1424.6896 -0.0675 0 77 9.1e-007 1 R.APSTYGGGLSVSSSR.F 14516 14517 14518 14519 14520 14521 1452

6. P08779|K1C16_HUMAN Mass: 51578 Score: 3111 Queries matched: 212 emPAI: 1.48 Keratin, type I cytoskeletal 16 OS=Homo sapiens GN=KRT16 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1710 404.1961 806.3776 806.3923 -0.0146 0 55 0.00018 1 R.LAADDFR.T 64 65 1700 1701 1702 1703 1704 1705 1706 1707 1708 1860 405.2101 808.4057 808.4330 -0.0273 0 47 0.001 1 R.LASYLDK.V 1859 1861 1863 1864 1865 1866 1867 1868 1869 1870 2636 417.2104 832.4063 832.4290 -0.0227 0 16 1.7 4 R.SEVTELR.R 6541 460.2102 918.4057 918.4123 -0.0066 0 21 0.52 1 K.DYSPYFK.T 6540 6542 7984 495.2528 988.4911 988.5301 -0.0390 1 18 0.87 1 R.SEVTELRR.V 7986 7990 7992 7994 1319 515.2978 1028.5810 1028.5866 -0.0056 0 44 0.0081 1 R.VLDELTLAR.T 1308 8862 8882 1313 1315 1316 1317 8902 1320 9059 518.7686 1035.5227 1035.5250 -0.0022 1 14 2.1 1 K.IRDWYQR.Q 9818 532.8017 1063.5889 1063.6026 -0.0137 1 60 5.6e-005 1 R.LASYLDKVR.A 9810 9811 9812 9813 9814 9816 9817 10410 545.7462 1089.4778 1089.5237 -0.0458 0 (64) 2.3e-005 1 K.VTMQNLNDR.L 10411 10412 10413 10414 10415 10416 10417 10418 10537 548.7607 1095.5069 1095.5237 -0.0168 0 34 0.022 1 R.DAETWFLSK.T 10624 553.7548 1105.4951 1105.5186 -0.0235 0 66 1.6e-005 1 K.VTMQNLNDR.L 10616 10617 10618 1418 10619 10620 10621 10622 10655 553.7800 1105.5454 1105.5550 -0.0096 0 77 1.1e-006 1 R.ISSVLAGGSCR.A 10632 10646 10647 10648 10650 10651 10652 10 1482 593.2833 1184.5520 1184.6877 -0.1357 1 5 46 4 R.RVLDELTLAR.T 12324 401.2207 1200.6404 1200.6099 0.0305 0 5 15 3 R.QTVEADVNGLR.R 12325 12328 12329 12331 12552 610.7985 1219.5824 1219.5932 -0.0108 0 72 3.1e-006 1 K.ASLENSLEETK.G 12548 12550 12551 13083 630.7835 1259.5525 1259.5630 -0.0104 0 54 0.00019 1 R.EVFTSSSSSSSR.Q 13303 639.7903 1277.5660 1277.5783 -0.0123 0 89 6e-008 1 K.GSCGIGGGIGGGSSR.I 13296 13297 13298 13299 13300 13301 1330 13550 651.3254 1300.6363 1300.6510 -0.0147 0 96 1.2e-008 1 R.ALEEANADLEVK.I 13536 13537 13539 13540 13541 13542 13543 13 13884 669.8248 1337.6351 1337.6575 -0.0225 0 63 2.5e-005 1 R.APSTYGGGLSVSSR.F 13881 13883

7. P02768|ALBU_HUMAN Mass: 71317 Score: 2555 Queries matched: 197 emPAI: 1.37 Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5296 438.2463 874.4781 874.5025 -0.0243 1 15 2.5 1 R.LSQRFPK.A 5297 5298 5301 5378 440.7191 879.4237 879.4338 -0.0101 0 55 0.00018 1 K.AEFAEVSK.L 5356 5357 5358 5359 5360 5362 5363 5366 5368 536 6644 464.2468 926.4791 926.4861 -0.0070 0 45 0.0014 1 K.YLYEIAR.R 6606 6608 6609 6610 6612 6613 6614 6615 6616 6620 6853 467.2538 932.4930 932.5113 -0.0183 0 47 0.0014 1 K.LCTVATLR.E 6846 6848 6849 6850 6851 6852 6855 6856 6857 6858 6976 470.7188 939.4229 939.4410 -0.0180 0 54 0.00019 1 K.DDNPNLPR.L 6972 6973 6974 6975 6977 6978 6979 6981 6982 6983 7234 476.2175 950.4204 950.4345 -0.0141 0 28 0.1 1 K.DLGEENFK.A 1155 7241 7437 480.7753 959.5359 959.5552 -0.0193 0 56 0.00015 1 K.FQNALLVR.Y 7436 7438 7444 7874 492.7404 983.4663 983.4811 -0.0148 0 61 3.9e-005 1 K.TYETTLEK.C 7868 7869 7870 7871 7872 7873 7875 7876 7877 7878 8179 500.7945 999.5744 999.5964 -0.0220 0 65 2.1e-005 1 K.QTALVELVK.H 8176 8184 8498 507.2907 1012.5669 1012.5917 -0.0248 0 50 0.00047 1 K.LVAASQAALGL.- 8494 8496 8497 8499 8500 8501 8502 8503 8504 8 10074 537.7697 1073.5249 1073.5353 -0.0104 1 54 0.00027 1 K.LDELRDEGK.A 10060 1385 10062 10063 10064 10065 10067 10068 11376 569.7463 1137.4780 1137.4907 -0.0127 0 40 0.0044 1 K.CCTESLVNR.R 11501 575.2816 1148.5485 1148.6077 -0.0592 0 62 3.6e-005 1 K.LVNEVTEFAK.T 11500 11502 11503 11504 11505 11506 1461 11507 12667 409.5359 1225.5860 1225.5979 -0.0119 1 13 2.6 1 R.FKDLGEENFK.A 13570 435.8626 1304.5661 1304.6104 -0.0443 0 4 19 1 K.ECCEKPLLEK.S 14207 686.2640 1370.5134 1370.5595 -0.0461 0 79 3.3e-007 1 K.AAFTECCQAADK.A 14208 14209 14210 1532 14211 14212 14213 142 14635 722.3113 1442.6081 1442.6347 -0.0266 0 82 2.7e-007 1 K.YICENQDSISSK.L 1537 14628 14629 14630 14631 14632 14633 14 14865 749.7738 1497.5331 1497.5712 -0.0381 0 101 1.2e-009 1 K.TCVADESAENCDK.S 14863 14864 14866 14867 500.5379 1498.5918 1498.6246 -0.0328 1 42 0.0016 1 K.ADDKETCFAEEGK.K 15005 516.2544 1545.7413 1545.7894 -0.0482 1 13 1.9 1 K.LKECCEKPLLEK.S 15141 547.3085 1638.9036 1638.9305 -0.0268 1 53 0.00019 1 K.KVPQVSTPTLVEVSR.N 15138 15139 15140 15142

8. P13647|K2C5_HUMAN Mass: 62568 Score: 2134 Queries matched: 211 emPAI: 2.36 Keratin, type II cytoskeletal 5 OS=Homo sapiens GN=KRT5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1909 405.7086 809.4026 809.4032 -0.0005 0 53 0.00023 1 R.QSSVSFR.S 274 414.2153 826.4159 826.4225 -0.0066 0 36 0.024 1 K.FASFIDK.V 2405 2406 270 2408 2410 2411 2412 2413 2414 2415 2 5447 442.7214 883.4283 883.4400 -0.0116 0 40 0.0051 1 R.TSFTSVSR.S 5444 5446 5449 5450 6176 453.7254 905.4363 905.4607 -0.0244 0 49 0.00081 1 R.FLEQQNK.V 6169 6170 6171 6172 6173 6175 6178 6179 6180 6181 6924 469.7449 937.4752 937.4869 -0.0117 0 36 0.011 1 R.SLYNLGGSK.R 6920 6922 7112 473.2462 944.4778 944.5039 -0.0262 1 45 0.0023 1 R.GRLDSELR.N 7108 7109 7110 7111 7113 7114 7115 7116 7119 7120 7560 486.2382 970.4618 970.4720 -0.0102 0 36 0.014 1 K.FVSTTSSSR.K 8412 503.2351 1004.4556 1004.4597 -0.0041 0 58 0.0001 1 K.LLEGEECR.L 8396 8397 8398 8399 8400 8401 8402 8403 8404 8405 8532 508.2349 1014.4553 1014.4552 0.0001 0 11 5.2 1 K.HEISEMNR.M 8579 508.7705 1015.5264 1015.5298 -0.0034 0 49 0.00074 1 R.QLDSIVGER.G 8566 8567 8568 8569 8571 8572 8573 8574 8576 857 8827 513.7301 1025.4457 1025.4488 -0.0030 0 28 0.07 1 K.DVDAAYMNK.V 9893 533.7607 1065.5069 1065.5090 -0.0021 1 49 0.00065 1 K.YEDEINKR.T 9885 9886 9888 9889 9890 9891 10494 547.2550 1092.4954 1092.5199 -0.0245 0 62 3.2e-005 1 K.AQYEEIANR.S 10482 10486 10487 10488 10491 10492 10493 10495 10529 547.7601 1093.5057 1093.5880 -0.0823 1 4 18 5 R.SLYNLGGSKR.I 10805 556.2712 1110.5279 1110.5669 -0.0390 0 69 6e-006 1 R.ISISTSGGSFR.N 10806 10807 10808 10809 10810 10811 10812 142 11226 567.2803 1132.5460 1132.5546 -0.0086 1 62 3.6e-005 1 R.KLLEGEECR.L 11222 11460 572.3107 1142.6067 1142.6183 -0.0115 0 57 0.00012 1 K.LAELEEALQK.A 11596 576.7709 1151.5273 1151.5458 -0.0185 1 41 0.0042 1 K.NKYEDEINK.R 11594 12128 597.7878 1193.5611 1193.5676 -0.0065 0 92 3.3e-008 1 K.YEELQQTAGR.H 12111 12113 12114 12115 12116 12117 12118 1211 12340 602.3159 1202.6172 1202.6295 -0.0123 0 42 0.0033 1 K.WTLLQEQGTK.T 12339 12876 621.7780 1241.5414 1241.5564 -0.0150 0 64 2.1e-005 1 R.TEAESWYQTK.Y 12875 13002 627.7929 1253.5712 1253.6113 -0.0400 1 12 3 2 R.QSSVSFRSGGSR.S 12991 12993 12994 12995 12996 12997 13000 13 13314 641.8101 1281.6056 1281.6275 -0.0219 0 59 4.9e-005 1 R.TTAENEFVMLK.K

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14436 705.8576 1409.7007 1409.7151 -0.0144 0 68 6.5e-006 1 R.SFSTASAITPSVSR.T 14558 720.3491 1438.6835 1438.7053 -0.0217 0 79 5.7e-007 1 R.GLGVGFGSGGGSSSSVK.F 1318 515.2894 1542.8463 1542.7395 0.1068 1 1 1.5e+002 2 K.HEISEMNRMIQR.L

9. P04259|K2C6B_HUMAN Mass: 60315 Score: 2126 Queries matched: 179 emPAI: 1.31 Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 274 414.2153 826.4159 826.4225 -0.0066 0 36 0.024 1 K.FASFIDK.V 2405 2406 270 2408 2410 2411 2412 2413 2414 2415 2 5399 441.2389 880.4633 880.4654 -0.0021 0 36 0.012 1 R.SLYGLGGSK.R 5393 5394 5395 5396 5397 5398 5400 6176 453.7254 905.4363 905.4607 -0.0244 0 49 0.00081 1 R.FLEQQNK.V 6169 6170 6171 6172 6173 6175 6178 6179 6180 6181 7112 473.2462 944.4778 944.5039 -0.0262 1 45 0.0023 1 R.GRLDSELR.N 7108 7109 7110 7111 7113 7114 7115 7116 7119 7120 7587 486.7497 971.4849 971.5036 -0.0186 0 67 1.2e-005 1 K.QEIAEINR.M 7589 7590 7591 8412 503.2351 1004.4556 1004.4597 -0.0041 0 58 0.0001 1 K.LLEGEECR.L 8396 8397 8398 8399 8400 8401 8402 8403 8404 8405 8827 513.7301 1025.4457 1025.4488 -0.0030 0 28 0.07 1 K.DVDAAYMNK.V 8828 513.7575 1025.5005 1025.5142 -0.0137 0 76 1.3e-006 1 R.SGFSSISVSR.S 9893 533.7607 1065.5069 1065.5090 -0.0021 1 49 0.00065 1 K.YEDEINKR.T 9885 9886 9888 9889 9890 9891 10743 554.2662 1106.5178 1106.5356 -0.0178 0 68 8.9e-006 1 K.AQYEEIAQR.S 10724 10725 10727 10728 10729 10730 10731 10733 11226 567.2803 1132.5460 1132.5546 -0.0086 1 62 3.6e-005 1 R.KLLEGEECR.L 11222 11596 576.7709 1151.5273 1151.5458 -0.0185 1 41 0.0042 1 K.NKYEDEINK.R 11594 12026 590.2986 1178.5827 1178.5931 -0.0104 0 87 9.9e-008 1 K.YEELQITAGR.H 12000 12001 12002 12003 12004 12005 12006 1200 12340 602.3159 1202.6172 1202.6295 -0.0123 0 42 0.0033 1 K.WTLLQEQGTK.T 12339 12631 611.8139 1221.6132 1221.6241 -0.0109 0 16 1.2 1 R.TAAENEFVTLK.K 13991 450.9031 1349.6875 1349.7191 -0.0316 1 3 24 2 R.TAAENEFVTLKK.D 13990 14514 712.8068 1423.5990 1423.6263 -0.0273 0 60 4e-005 1 R.GSGGLGGACGGAGFGSR.S 14513

10. Q04695|K1C17_HUMAN Mass: 48361 Score: 1990 Queries matched: 161 emPAI: 0.95 Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1710 404.1961 806.3776 806.3923 -0.0146 0 55 0.00018 1 R.LAADDFR.T 64 65 1700 1701 1702 1703 1704 1705 1706 1707 1708 1860 405.2101 808.4057 808.4330 -0.0273 0 47 0.001 1 R.LASYLDK.V 1859 1861 1863 1864 1865 1866 1867 1868 1869 1870 2485 415.7113 829.4081 829.4658 -0.0577 1 2 43 8 K.KEPVTTR.Q 2636 417.2104 832.4063 832.4290 -0.0227 0 30 0.065 1 K.SEISELR.R 7667 487.7469 973.4793 973.5080 -0.0287 0 34 0.029 1 R.TIEELQNK.I 7668 7669 7670 7672 7677 7682 7729 7750 7751 7868 492.7301 983.4456 983.4924 -0.0467 0 10 5 10 R.QFTSSSSIK.G 7990 495.2598 988.5050 988.5301 -0.0252 1 28 0.1 1 K.SEISELRR.T 7984 7985 7986 7992 7993 7996 8055 497.2353 992.4560 992.4927 -0.0367 0 2 33 10 K.FETEQALR.L 8086 497.7145 993.4145 993.4192 -0.0047 0 29 0.063 1 R.DYSQYYR.T 8085 1319 515.2978 1028.5810 1028.5866 -0.0056 0 44 0.0081 1 R.VLDELTLAR.A 1308 8862 8882 1313 1315 1316 1317 8902 1320 9007 517.7421 1033.4696 1033.4975 -0.0279 0 34 0.022 1 R.LSGGLGAGSCR.L 9008 9009 9059 518.7686 1035.5227 1035.5250 -0.0022 1 14 2.1 1 K.IRDWYQR.Q 9747 531.8050 1061.5954 1061.4924 0.1030 0 2 42 2 K.ATMQNLNDR.L 9746 9818 532.8017 1063.5889 1063.6026 -0.0137 1 60 5.6e-005 1 R.LASYLDKVR.A 9810 9811 9812 9813 9814 9816 9817 11605 579.2554 1156.4961 1156.5070 -0.0109 1 1 37 10 R.DQYEKMAEK.N 1482 593.2833 1184.5520 1184.6877 -0.1357 1 5 46 4 R.RVLDELTLAR.A 13973 673.3302 1344.6458 1344.6772 -0.0314 0 68 7.5e-006 1 R.ALEEANTELEVK.I 13971 13972 13974 14102 681.3307 1360.6469 1360.6834 -0.0365 0 101 4.3e-009 1 R.EVATNSELVQSGK.S 14097 14098 14099 14100 14101 14103 14104 1 15158 553.9362 1658.7867 1658.8839 -0.0972 1 2 25 6 R.TIVEEVQDGKVISSR.E

11. P60709|ACTB_HUMAN Mass: 42052 Score: 1843 Queries matched: 104 emPAI: 2.03 Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1605 400.7674 799.5202 799.5280 -0.0078 1 25 0.21 1 K.RGILTLK.Y 1604 6154 453.2257 904.4369 904.4436 -0.0068 1 34 0.027 1 K.CDVDIRK.D 6152 6153 6586 462.2831 922.5516 922.5600 -0.0083 1 35 0.015 1 K.IIAPPERK.Y 6583 6584 6585 6587 6588 7783 488.7206 975.4266 975.4410 -0.0144 0 74 2.5e-006 1 K.AGFAGDDAPR.A 7764 7765 7766 7767 7768 7769 7770 7771 7772 77 8130 499.7475 997.4804 997.4790 0.0014 0 (35) 0.016 1 R.DLTDYLMK.I 8128 8129 8511 507.7357 1013.4567 1013.4739 -0.0172 0 44 0.0022 1 R.DLTDYLMK.I 8510 8512 8513 8514 8515 8516 8517 8518 8519 11210 566.7600 1131.5054 1131.5197 -0.0143 0 73 3e-006 1 R.GYSFTTTAER.E 11197 11198 11199 11200 11201 11202 11203 1120 11679 581.2971 1160.5797 1160.6111 -0.0314 0 60 5.1e-005 1 K.EITALAPSTMK.I 11678 11680 11681 11686 11878 589.2918 1176.5691 1176.6060 -0.0369 0 (44) 0.0022 1 K.EITALAPSTMK.I 11877 11879 11880 11881 11882 11883 12292 599.7454 1197.4761 1197.5150 -0.0388 0 60 4.4e-005 1 K.DSYVGDEAQSK.R 12293 12294 12295 12296 12298 12299 12301 123 12336 602.2798 1202.5450 1202.5536 -0.0086 0 35 0.017 1 R.HQGVMVGMGQK.D 12335 14058 677.7997 1353.5848 1353.6161 -0.0312 1 62 3.1e-005 1 K.DSYVGDEAQSKR.G 14057 14059 14060 14061 14925 506.2294 1515.6665 1515.6954 -0.0289 0 36 0.011 1 K.QEYDESGPSIVHR.K 14926 15226 652.0241 1953.0505 1953.0571 -0.0066 0 15 0.83 1 R.VAPEEHPVLLTEAPLNPK.A

Proteins matching the same set of peptides: P63261|ACTG_HUMAN Mass: 42108 Score: 1843 Queries matched: 104 Actin, cytoplasmic 2 OS=Homo sapiens GN=ACTG1 PE=1 SV=1

12. P08670|VIME_HUMAN Mass: 53676 Score: 1695 Queries matched: 127 emPAI: 2.35 Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4688 435.7164 869.4182 869.4283 -0.0101 0 35 0.014 1 R.FANYIDK.V 749 4685 750 4686 4687 751 4689 4690 4691 4692 469 6176 453.7254 905.4363 905.4607 -0.0244 0 49 0.00081 1 R.FLEQQNK.I 6169 6170 6171 6172 6173 6175 6178 6179 6180 6181 6456 457.7264 913.4383 913.4505 -0.0122 0 23 0.26 1 R.SYVTTSTR.T 6832 466.7351 931.4556 931.4610 -0.0055 0 54 0.00023 1 K.LLEGEESR.I 1091 6820 6821 6822 6823 6824 6825 6826 6829 6830 8765 512.2595 1022.5045 1022.5033 0.0013 0 60 4.9e-005 1 R.QQYESVAAK.N 8755 8758 8759 8760 8762 8763 8764 9423 523.7682 1045.5218 1045.5226 -0.0008 0 30 0.062 1 K.LQEEMLQR.E 9644 530.7576 1059.5006 1059.5197 -0.0190 0 58 0.00011 1 R.QVDQLTNDK.A 9641 9642 9643 9645 9646 9656 9662 9677 530.7805 1059.5464 1059.5560 -0.0096 1 58 0.00011 1 R.KLLEGEESR.I 9678 9680 10140 538.7491 1075.4837 1075.4968 -0.0131 0 43 0.0025 1 R.DNLAEDIMR.L 10303 544.7636 1087.5126 1087.5258 -0.0132 0 67 1.2e-005 1 R.QDVDNASLAR.L 10297 10298 10299 10300 10301 10302 10304 10458 546.7464 1091.4782 1091.4917 -0.0135 0 (33) 0.026 1 R.DNLAEDIM R.L 10522 547.2677 1092.5209 1092.5200 0.0009 0 87 1.1e-007 1 K.FADLSEAANR.N 10490 10500 10508 10509 10511 10512 10514 1051 10836 558.2833 1114.5521 1114.5618 -0.0097 0 48 0.00092 1 K.VELQELNDR.F 10833 10834 1424 10837 10962 561.2891 1120.5636 1120.5764 -0.0128 0 60 6e-005 1 R.EYQDLLNVK.M 10944 10949 10955 10956 10957 10960 10963 10964

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12990 627.7759 1253.5373 1253.5598 -0.0224 0 51 0.00034 1 R.LGDLYEEEMR.E 13282 635.7792 1269.5439 1269.5547 -0.0108 0 (44) 0.002 1 R.LGDLYEEEM R.E 13396 429.8891 1286.6456 1286.6579 -0.0123 1 9 6 1 R.QVDQLTNDKAR.V 13590 655.2859 1308.5573 1308.5986 -0.0413 0 32 0.025 1 K.NLQEAEEWYK.S 13741 662.2894 1322.5642 1322.6102 -0.0460 0 80 4.3e-007 1 R.EEAENTLQSFR.Q 13742 13743 13744 15085 529.9267 1586.7581 1586.7900 -0.0319 1 3 22 1 R.TNEKVELQELNDR.F 15220 612.9274 1835.7603 1835.7922 -0.0319 0 10 2.7 1 R.DGQVINETSQHHDDLE.- 15219

13. P02538|K2C6A_HUMAN Mass: 60293 Score: 1405 Queries matched: 179 emPAI: 1.61 Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 274 414.2153 826.4159 826.4225 -0.0066 0 36 0.024 1 K.FASFIDK.V 2405 2406 270 2408 2410 2411 2412 2413 2414 2415 2 5399 441.2389 880.4633 880.4654 -0.0021 0 36 0.012 1 R.SLYGLGGSK.R 5393 5394 5395 5396 5397 5398 5400 6176 453.7254 905.4363 905.4607 -0.0244 0 49 0.00081 1 R.FLEQQNK.V 6169 6170 6171 6172 6173 6175 6178 6179 6180 6181 7112 473.2462 944.4778 944.5039 -0.0262 1 45 0.0023 1 R.GRLDSELR.G 7108 7109 7110 7111 7113 7114 7115 7116 7119 7120 7587 486.7497 971.4849 971.5036 -0.0186 0 67 1.2e-005 1 K.QEIAEINR.M 7589 7590 7591 8412 503.2351 1004.4556 1004.4597 -0.0041 0 58 0.0001 1 K.LLEGEECR.L 8396 8397 8398 8399 8400 8401 8402 8403 8404 8405 8486 506.7458 1011.4771 1011.4985 -0.0215 0 53 0.00023 1 R.SGFSSVSVSR.S 8483 8484 8487 1288 8488 8489 8579 508.7705 1015.5264 1015.5298 -0.0034 0 49 0.00074 1 R.QLDSIVGER.G 8566 8567 8568 8569 8571 8572 8573 8574 8576 857 8827 513.7301 1025.4457 1025.4488 -0.0030 0 28 0.07 1 K.DVDAAYMNK.V 9893 533.7607 1065.5069 1065.5090 -0.0021 1 49 0.00065 1 K.YEDEINKR.T 9885 9886 9888 9889 9890 9891 10743 554.2662 1106.5178 1106.5356 -0.0178 0 68 8.9e-006 1 K.AQYEEIAQR.S 10724 10725 10727 10728 10729 10730 10731 10733 11226 567.2803 1132.5460 1132.5546 -0.0086 1 62 3.6e-005 1 R.KLLEGEECR.L 11222 11596 576.7709 1151.5273 1151.5458 -0.0185 1 41 0.0042 1 K.NKYEDEINK.R 11594 11765 583.2899 1164.5652 1164.5775 -0.0123 0 71 3.9e-006 1 K.YEELQVTAGR.H 11749 1466 11768 12268 599.2633 1196.5120 1196.5383 -0.0264 0 4 19 4 R.GMQDLVEDFK.N 12265 12269 12271 12276 12278 12340 602.3159 1202.6172 1202.6295 -0.0123 0 42 0.0033 1 K.WTLLQEQGTK.T 12339 12631 611.8139 1221.6132 1221.6241 -0.0109 0 16 1.2 1 R.TAAENEFVTLK.K 13991 450.9031 1349.6875 1349.7191 -0.0316 1 3 24 2 R.TAAENEFVTLKK.D 13990 14514 712.8068 1423.5990 1423.6263 -0.0273 0 60 4e-005 1 R.GSGGLGGACGGAGFGSR.S 14513 14652 724.3750 1446.7354 1446.7678 -0.0325 0 68 7.5e-006 1 R.AIGGGLSSVGGGSSTIK.Y

14. P13646|K1C13_HUMAN Mass: 49900 Score: 1053 Queries matched: 74 emPAI: 0.33 Keratin, type I cytoskeletal 13 OS=Homo sapiens GN=KRT13 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1710 404.1961 806.3776 806.3923 -0.0146 0 55 0.00018 1 R.LAADDFR.L 64 65 1700 1701 1702 1703 1704 1705 1706 1707 1708 2091 412.2176 822.4206 822.4487 -0.0281 0 46 0.0014 1 R.LASYLEK.V 2090 226 2092 2093 2095 768 436.2349 870.4553 870.4195 0.0358 0 5 47 6 K.QSPASPER.D 7435 480.7538 959.4930 959.4924 0.0006 0 1 55 9 R.SLLEGQDAK.M 12322 601.3055 1200.5964 1200.6098 -0.0134 0 66 1.4e-005 1 R.QSVEADINGLR.R 13550 651.3254 1300.6363 1300.6510 -0.0147 0 96 1.2e-008 1 R.ALEEANADLEVK.I 13536 13537 13539 13540 13541 13542 13543 13 14086 453.2367 1356.6882 1356.7110 -0.0228 1 14 1.9 1 R.QSVEADINGLRR.V 14083 14085

15. P81605|DCD_HUMAN Mass: 11391 Score: 958 Queries matched: 45 emPAI: 0.82 Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5995 450.2561 898.4977 898.5600 -0.0623 1 8 8.1 10 K.AVGGLGKLGK.D 5983 6008 6037 6044 6055 11156 564.7570 1127.4994 1127.5207 -0.0212 0 77 1.2e-006 1 K.ENAGEDPGLAR.Q 11139 11140 11141 11142 11143 11144 11145 111 11672 581.2741 1160.5337 1160.5561 -0.0224 0 57 0.00012 1 K.DAVEDLESVGK.G 11668 11669 11671 11673 11674 11675 11676 11

16. Q86Y46|K2C73_HUMAN Mass: 59457 Score: 606 Queries matched: 80 emPAI: 0.44 Keratin, type II cytoskeletal 73 OS=Homo sapiens GN=KRT73 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 274 414.2153 826.4159 826.4225 -0.0066 0 36 0.024 1 K.FASFIDK.V 2405 2406 270 2408 2410 2411 2412 2413 2414 2415 2 7542 485.2205 968.4265 968.4451 -0.0186 0 6 11 8 K.DVDAAYTSK.V 8412 503.2351 1004.4556 1004.4597 -0.0041 0 58 0.0001 1 K.LLEGEECR.M 8396 8397 8398 8399 8400 8401 8402 8403 8404 8405 10061 537.7636 1073.5127 1073.5829 -0.0702 1 1 47 2 R.LDSELRSVR.E 10733 554.2603 1106.5060 1106.5720 -0.0660 1 54 0.00021 1 R.AQYEEIARK.S 10724 10725 10727 10728 10729 10730 10731 10734 10998 562.2755 1122.5364 1122.5557 -0.0192 0 42 0.003 1 K.AEAEALYQTK.F 11226 567.2803 1132.5460 1132.5546 -0.0086 1 62 3.6e-005 1 R.KLLEGEECR.M 11222 12031 590.7914 1179.5682 1179.5996 -0.0314 1 4 22 8 R.AGGKGLSGGFSSR.S 14084 679.3421 1356.6696 1356.7249 -0.0553 0 33 0.022 2 R.NLDLDSIIAEVR.A

17. P19013|K2C4_HUMAN Mass: 57649 Score: 596 Queries matched: 57 emPAI: 0.28 Keratin, type II cytoskeletal 4 OS=Homo sapiens GN=KRT4 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2054 408.7366 815.4586 815.4388 0.0198 0 14 3.2 4 R.AEIENIK.K 274 414.2153 826.4159 826.4225 -0.0066 0 36 0.024 1 K.FASFIDK.V 2405 2406 270 2408 2410 2411 2412 2413 2414 2415 2 8008 495.7870 989.5594 989.5757 -0.0163 0 24 0.25 1 K.IISTTTLNK.R 10743 554.2662 1106.5178 1106.5356 -0.0178 0 68 8.9e-006 1 R.AQYEEIAQR.S 10724 10725 10727 10728 10729 10730 10731 10733 10998 562.2755 1122.5364 1122.5557 -0.0192 0 42 0.003 1 K.AEAEALYQTK.V 14084 679.3421 1356.6696 1356.7249 -0.0553 0 33 0.022 2 R.NLDLDSIIAEVR.A

18. O95678|K2C75_HUMAN Mass: 59809 Score: 500 Queries matched: 125 emPAI: 0.44 Keratin, type II cytoskeletal 75 OS=Homo sapiens GN=KRT75 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 274 414.2153 826.4159 826.4225 -0.0066 0 36 0.024 1 K.FASFIDK.V 2405 2406 270 2408 2410 2411 2412 2413 2414 2415 2 6176 453.7254 905.4363 905.4607 -0.0244 0 49 0.00081 1 R.FLEQQNK.V 6169 6170 6171 6172 6173 6175 6178 6179 6180 6181 6563 461.7349 921.4552 921.4920 -0.0368 0 (10) 6 3 R.SLYNLGGAK.R 6561 6566 6569 6570 6576 6579 8412 503.2351 1004.4556 1004.4597 -0.0041 0 58 0.0001 1 K.LLEGEECR.L 8396 8397 8398 8399 8400 8401 8402 8403 8404 8405 8451 503.7391 1005.4636 1005.4549 0.0087 0 7 12 9 K.QEISEMNR.M 8448 8452 8827 513.7301 1025.4457 1025.4488 -0.0030 0 28 0.07 1 K.DVDAAYMNK.V 9893 533.7607 1065.5069 1065.5090 -0.0021 1 49 0.00065 1 R.YEDEINKR.T 9885 9886 9888 9889 9890 9891 10189 540.3198 1078.6250 1078.5043 0.1207 0 2 35 6 K.AQYEDIANR.S 11226 567.2803 1132.5460 1132.5546 -0.0086 1 62 3.6e-005 1 R.KLLEGEECR.L 11222

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11615 579.2840 1156.5535 1156.6339 -0.0804 0 5 15 9 K.LVDLEEALQK.A 11765 583.2899 1164.5652 1164.5775 -0.0123 0 71 3.9e-006 1 K.YEELQVTAGR.H 11749 1466 11768 12247 599.2263 1196.4381 1196.5786 -0.1405 0 2 20 10 R.QSSITFQSGSR.R 12237 12239 12242 12246 14119 683.2945 1364.5744 1364.6354 -0.0610 1 11 3.8 4 R.NTKQEISEMNR.M 14118 14121 14122 14123 14125 14126 14128 141

19. P04075|ALDOA_HUMAN Mass: 39851 Score: 480 Queries matched: 30 emPAI: 0.88 Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1616 401.2357 800.4568 800.4756 -0.0188 0 45 0.0022 1 R.ALQASALK.A 1608 1611 1613 1615 1619 1620 3677 422.7679 843.5211 843.5178 0.0033 1 22 0.42 1 K.SKGGVVGIK.V 3676 6915 469.2302 936.4459 936.4552 -0.0093 0 23 0.26 1 K.AAQEEYVK.R 6914 6994 470.7433 939.4721 939.4774 -0.0052 0 47 0.0011 1 K.ELSDIAHR.I 6993 9194 522.7791 1043.5436 1043.5611 -0.0175 0 45 0.0018 1 R.QLLLTADDR.V 9192 9195 9828 533.2453 1064.4760 1064.5039 -0.0279 1 4 21 7 K.DGADFAKWR.C 10524 547.2805 1092.5465 1092.5563 -0.0098 1 60 5e-005 1 K.AAQEEYVKR.A 10525 11217 566.7846 1131.5547 1131.5706 -0.0159 0 66 1.3e-005 1 R.ALANSLACQGK.Y 11215 11216 11218 13814 666.8434 1331.6722 1331.6932 -0.0210 0 94 2.1e-008 1 K.GILAADESTGSIAK.R 13812 13813 13815 13945 448.2354 1341.6843 1341.7041 -0.0198 0 6 10 2 K.ADDGRPFPQVIK.S 15146 549.6035 1645.7886 1645.8019 -0.0133 1 22 0.23 1 R.LQSIGTENTEENRR.F 15147

20. Q2M2I5|K1C24_HUMAN Mass: 55567 Score: 441 Queries matched: 49 emPAI: 0.14 Keratin, type I cytoskeletal 24 OS=Homo sapiens GN=KRT24 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1710 404.1961 806.3776 806.3923 -0.0146 0 55 0.00018 1 R.LAADDFR.L 64 65 1700 1701 1702 1703 1704 1705 1706 1707 1708 9795 532.3738 1062.7331 1062.5379 0.1952 0 0 30 1 K.VLDDLTMTR.S 12322 601.3055 1200.5964 1200.6098 -0.0134 0 66 1.4e-005 1 R.QSVEADINGLR.K

21. P21333|FLNA_HUMAN Mass: 283301 Score: 419 Queries matched: 44 emPAI: 0.28 Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1904 405.2247 808.4348 808.4265 0.0083 0 23 0.3 1 K.YVICVR.F 2479 415.2366 828.4586 828.4705 -0.0119 0 18 1 1 K.AIVDGNLK.L 291 794 441.7701 881.5257 881.5334 -0.0078 0 28 0.078 1 K.AGVAPLQVK.V 6918 469.2515 936.4885 936.4916 -0.0031 1 27 0.098 1 R.VKETADFK.V 7247 476.7418 951.4691 951.4662 0.0030 0 46 0.0013 1 R.AEFTVETR.S 8458 504.2459 1006.4772 1006.4277 0.0495 0 2 36 10 R.DAEMPATEK.D 1283 504.2573 1006.5000 1006.5196 -0.0196 0 21 1.6 1 K.IQQNTFTR.W 8495 507.2866 1012.5586 1012.5665 -0.0079 1 38 0.0083 1 K.VKAEGPGLSR.T 8493 8908 516.2601 1030.5057 1030.5155 -0.0098 1 1 49 10 K.VTANNDKNR.T 9561 527.2446 1052.4746 1052.4775 -0.0029 0 40 0.0051 1 R.NDNDTFTVK.Y 9872 533.2633 1064.5121 1064.5325 -0.0203 0 16 1.2 2 R.LSPFMADIR.D 9859 9874 10155 540.2852 1078.5558 1078.5520 0.0039 0 34 0.022 1 R.VNVGAGSHPNK.V 10231 541.2645 1080.5145 1080.5451 -0.0306 1 1 43 6 K.DQEFTVKSK.G 1390 542.2585 1082.5025 1082.5284 -0.0259 0 31 0.1 1 K.SPFEVYVDK.S 10577 550.2646 1098.5146 1098.5669 -0.0523 0 41 0.0043 1 K.GTVEPQLEAR.G 1413 11602 578.3101 1154.6057 1154.6118 -0.0061 0 55 0.00013 1 K.IVGPSGAAVPCK.V 11773 584.2962 1166.5779 1166.5932 -0.0153 0 49 0.00064 1 K.VPVHDVTDASK.V 12267 599.2610 1196.5074 1196.5211 -0.0136 0 46 0.0012 1 R.DAPQDFHPDR.V 12237 12239 12240 12242 12246 12247 12248 1224 12661 613.2838 1224.5531 1224.5622 -0.0092 0 62 2.6e-005 1 R.EATTEFSVDAR.A 13411 645.8241 1289.6336 1289.6404 -0.0069 0 29 0.055 1 K.YGGQPVPNFPSK.L 13696 656.8353 1311.6561 1311.6783 -0.0222 0 38 0.0067 1 K.VEPGLGADNSVVR.F 14117 455.5707 1363.6901 1363.6984 -0.0082 1 0 43 1 K.VDVGKDQEFTVK.S 14541 715.3583 1428.7020 1428.7110 -0.0089 0 77 9.8e-007 1 K.AFGPGLQGGSAGSPAR.F 14553 717.8628 1433.7111 1433.7151 -0.0039 0 37 0.0094 1 R.ANLPQSFQVDTSK.A 15047 785.8916 1569.7686 1569.7999 -0.0313 0 79 5.9e-007 1 R.GAGTGGLGLAVEGPSEAK.M 15115 541.2628 1620.7665 1620.8988 -0.1322 1 2 25 3 K.HVGSRLYSVSYLLK.D 15153 826.9160 1651.8174 1651.8529 -0.0355 0 69 5e-006 1 K.VTAQGPGLEPSGNIANK.T 15167 419.9691 1675.8472 1675.7876 0.0596 1 2 23 3 K.AYVGQKSSFTVDCSK.A

22. P06396|GELS_HUMAN Mass: 86043 Score: 414 Queries matched: 34 emPAI: 0.40 Gelsolin OS=Homo sapiens GN=GSN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 338 420.1985 838.3825 838.4007 -0.0182 0 27 0.33 1 R.LFACSNK.I 2713 2714 3796 425.7318 849.4490 849.4709 -0.0219 1 20 0.59 1 K.KGGVASGFK.H 3791 3797 5282 437.7660 873.5175 873.5284 -0.0108 1 16 2 1 R.LKATQVSK.G 5412 441.7337 881.4529 881.4494 0.0035 0 48 0.0007 1 K.TASDFITK.M 5405 5406 5407 5408 5409 5410 5411 5621 444.2493 886.4840 886.4872 -0.0032 0 75 2.3e-006 1 K.TGAQELLR.V 5613 5615 5616 5617 5619 5620 5622 6454 457.2902 912.5659 912.5757 -0.0097 1 30 0.051 1 R.RTPITVVK.Q 6452 7428 480.2291 958.4436 958.5560 -0.1123 1 2 37 10 K.ATQVSKGIR.D 10153 539.7595 1077.5045 1077.5091 -0.0045 0 42 0.0038 1 R.YIETDPANR.D 10149 10152 11767 583.2935 1164.5724 1164.6073 -0.0349 1 4 21 8 R.LFACSNKIGR.F 13730 660.3457 1318.6769 1318.6881 -0.0112 0 62 3.1e-005 1 K.AGALNSNDAFVLK.T 13729 13988 450.5495 1348.6266 1348.6371 -0.0105 1 24 0.2 1 R.YIETDPANRDR.R 15164 555.9252 1664.7538 1664.7740 -0.0202 1 44 0.0013 1 K.DSQEEEKTEALTSAK.R

23. P05783|K1C18_HUMAN Mass: 48029 Score: 406 Queries matched: 70 emPAI: 0.08 Keratin, type I cytoskeletal 18 OS=Homo sapiens GN=KRT18 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1710 404.1961 806.3776 806.3923 -0.0146 0 55 0.00018 1 R.LAADDFR.V 64 65 1700 1701 1702 1703 1704 1705 1706 1707 1708 1 2652 419.2148 836.4151 836.4392 -0.0241 0 5 16 1 R.LASYLDR.V 10515 547.2604 1092.5063 1092.5563 -0.0500 1 13 2.6 3 R.AQYDELARK.N 10482 10486 10487 10491 10492 10493 10494 10495 13730 660.3457 1318.6769 1318.6629 0.0140 0 4 21 4 R.AQIFANTVDNAR.I

24. P08238|HS90B_HUMAN Mass: 83554 Score: 360 Queries matched: 22 emPAI: 0.54 Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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1907 405.6860 809.3574 809.3742 -0.0167 0 27 0.09 1 K.FENLCK.L 297 415.2475 828.4804 828.5221 -0.0418 0 19 1.5 1 R.ALLFIPR.R 296 5337 440.2252 878.4359 878.4167 0.0192 0 9 7.9 10 R.EMLQQSK.I 5692 446.2163 890.4181 890.4174 0.0007 0 21 0.58 1 K.FYEAFSK.N 5689 9101 520.2447 1038.4748 1038.4869 -0.0121 0 64 1.9e-005 1 R.YESLTDPSK.L 9103 9237 523.2732 1044.5319 1044.5927 -0.0608 1 3 29 9 K.VEKVTISNR.L 9220 9274 11584 576.2754 1150.5363 1150.5506 -0.0143 0 22 0.34 1 K.YIDQEELNK.T 11666 580.7836 1159.5527 1159.5761 -0.0233 0 44 0.0023 1 K.SIYYITGESK.E 12135 597.8227 1193.6308 1193.6404 -0.0096 0 31 0.041 1 K.IDIIPNPQER.T 12134 12879 621.8360 1241.6574 1241.6979 -0.0405 0 59 7e-005 1 K.ADLINNLGTIAK.S 12880 12881 12919 625.2864 1248.5583 1248.6098 -0.0515 0 73 2.5e-006 1 K.EQVANSAFVER.V 12923 13687 656.2675 1310.5204 1310.5626 -0.0422 0 62 2.3e-005 1 K.EDQTEYLEER.R 14143 683.3573 1364.7000 1364.7221 -0.0221 0 64 2e-005 1 R.TLTLVDTGIGM TK.A

25. P00338|LDHA_HUMAN Mass: 36950 Score: 356 Queries matched: 23 emPAI: 0.47 L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6447 457.2659 912.5173 912.5756 -0.0584 0 50 0.0005 1 K.LVIITAGAR.Q 6449 6450 6453 6455 6724 465.2855 928.5564 928.5746 -0.0182 0 9 7.6 7 K.FIIPNVVK.Y 6721 6723 8478 506.2286 1010.4426 1010.4669 -0.0243 0 53 0.00025 1 K.DYNVTANSK.L 8477 11321 567.7797 1133.5448 1133.5564 -0.0116 0 60 4.8e-005 1 K.VTLTSEEEAR.L 11315 11316 11317 1446 11318 11319 11320 12915 624.7895 1247.5644 1247.5928 -0.0284 0 67 1e-005 1 R.VIGSGCNLDSAR.F 12913 12914 12916 13140 632.8136 1263.6127 1263.6711 -0.0584 0 17 0.98 1 K.QVVESAYEVIK.L

26. P40121|CAPG_HUMAN Mass: 38779 Score: 353 Queries matched: 14 emPAI: 0.59 Macrophage-capping protein OS=Homo sapiens GN=CAPG PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6492 458.7484 915.4823 915.5025 -0.0202 0 39 0.0072 1 K.TSTGAPAAIK.K 6493 6495 6498 8689 510.7561 1019.4977 1019.5399 -0.0422 0 62 4e-005 1 K.ANAQAAALYK.V 8710 8717 8718 9204 522.8106 1043.6066 1043.5975 0.0091 1 31 0.04 1 K.TSTGAPAAIKK.L 13312 640.8048 1279.5950 1279.6078 -0.0128 0 49 0.00057 1 K.VSDATGQMNLTK.V 13723 659.2765 1316.5384 1316.5732 -0.0348 0 84 1.7e-007 1 K.EGNPEEDLTADK.A 13724 13725 13726

27. P13796|PLSL_HUMAN Mass: 70815 Score: 349 Queries matched: 25 emPAI: 1.15 Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1918 406.2039 810.3932 810.4058 -0.0126 0 31 0.037 1 K.YAISMAR.K 2407 414.2015 826.3884 826.4007 -0.0123 0 (22) 0.29 1 K.YAISM AR.K 5504 443.2253 884.4361 884.4505 -0.0144 0 33 0.027 1 K.VPVDWNR.V 7041 471.7723 941.5300 941.5334 -0.0034 0 40 0.0047 1 R.VNKPPYPK.L 7040 8088 497.7543 993.4940 993.5131 -0.0191 0 59 6.4e-005 1 K.IGNFSTDIK.D 9902 535.3005 1068.5864 1068.6179 -0.0315 0 5 15 2 K.LSPEELLLR.W 10311 545.2241 1088.4336 1088.4557 -0.0220 0 48 0.00092 1 K.ALENDPDCR.H 10312 10316 10319 10841 559.2826 1116.5506 1116.5750 -0.0243 0 30 0.062 1 K.AACLPLPGYR.V 11351 568.3019 1134.5892 1134.6033 -0.0142 0 55 0.00018 1 R.QFVTATDVVR.G 11349 11350 11515 575.7617 1149.5089 1149.5223 -0.0134 0 78 8.2e-007 1 R.EGESLEDLMK.L 11772 583.7564 1165.4982 1165.5172 -0.0190 0 (36) 0.012 1 R.EGESLEDLM K.L 12044 591.7917 1181.5687 1181.5928 -0.0241 1 38 0.0081 1 K.SSSISSFKDPK.I 1508 618.2692 1234.5239 1234.5434 -0.0195 0 37 0.034 1 R.AECMLQQAER.L 12972 626.2663 1250.5180 1250.5383 -0.0204 0 (24) 0.18 1 R.AECM LQQAER.L 13747 442.2269 1323.6589 1323.6670 -0.0082 1 19 0.53 1 K.IGNFSTDIKDSK.A 14435 705.3303 1408.6461 1408.6656 -0.0195 0 74 1.8e-006 1 K.LENCNYAVELGK.N 15102 539.9213 1616.7422 1616.7641 -0.0220 1 55 0.00013 1 K.TENLNDDEKLNNAK.Y 15100 15101

28. P02649|APOE_HUMAN Mass: 36246 Score: 345 Queries matched: 24 emPAI: 0.64 Apolipoprotein E OS=Homo sapiens GN=APOE PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 824 443.7572 885.4998 885.4668 0.0330 0 9 8.7 1 K.ELQAAQAR.L 5565 7208 474.7548 947.4950 947.5188 -0.0238 0 53 0.0003 1 R.LAVYQAGAR.E 7205 7206 7207 7209 7211 7536 484.7691 967.5236 967.5451 -0.0215 0 55 0.00014 1 R.LGPLVEQGR.V 1195 7535 7537 7538 7539 7540 7541 9001 517.2655 1032.5164 1032.5352 -0.0188 0 42 0.0035 1 R.LQAEAFQAR.L 8980 8991 8998 9000 9003 13709 657.3589 1312.7032 1312.7099 -0.0067 1 38 0.0077 1 R.AKLEEQAQQIR.L 15114 810.9026 1619.7907 1619.7904 0.0003 0 40 0.004 1 K.VQAAVGTSAAPVPSDNH.-

29. Q5VSK2|MRC1L_HUMAN Mass: 168904 Score: 329 Queries matched: 18 emPAI: 0.19 Macrophage mannose receptor 1-like protein 1 OS=Homo sapiens GN=MRC1L1 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2286 413.1947 824.3749 824.3817 -0.0068 0 20 0.52 1 K.TWFESR.D 4307 430.1954 858.3763 858.3905 -0.0143 0 10 8.2 1 K.SSYSLMR.Q 5412 441.7337 881.4529 881.3668 0.0862 0 8 8.5 8 K.DGYWADR.G 5407 5886 449.2153 896.4160 896.4174 -0.0014 0 27 0.1 1 R.GYICQTR.S 5882 7471 481.2305 960.4464 960.4699 -0.0235 0 43 0.0033 1 K.SCVSLNPGK.N 7472 10144 538.7857 1075.5568 1075.5662 -0.0094 0 35 0.016 1 R.LITASGSYHK.L 10820 557.2410 1112.4674 1112.4815 -0.0141 0 18 0.67 1 K.DYQYYFSK.E 10821 11840 586.8051 1171.5956 1171.6197 -0.0241 0 51 0.00042 1 R.ALGGDLASINNK.E 12112 597.7647 1193.5148 1193.5353 -0.0204 0 62 3.3e-005 1 R.YTNWAADEPK.L 27 403.1592 1206.4557 1206.5703 -0.1146 1 0 2.4e+002 5 K.YGKSSYSLMR.Q 12517 607.8090 1213.6034 1213.6190 -0.0156 0 78 7.9e-007 1 R.SQGPEIVEVEK.G 12518 13498 650.2927 1298.5708 1298.5925 -0.0217 0 74 1.7e-006 1 K.IYGTTDNLCSR.G 13499

Proteins matching the same set of peptides: P22897|MRC1_HUMAN Mass: 168870 Score: 329 Queries matched: 18 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1

30. P07355|ANXA2_HUMAN Mass: 38808 Score: 321 Queries matched: 27 emPAI: 0.74

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Annexin A2 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1853 404.7335 807.4525 807.4603 -0.0078 0 25 0.17 1 R.SVPHLQK.V 1852 1854 2650 419.2044 836.3943 836.3950 -0.0006 0 8 8.1 2 R.SEVDMLK.I 5227 437.2665 872.5185 872.5517 -0.0332 1 7 15 1 R.KLMVALAK.G 5234 5236 5377 440.7186 879.4227 879.4338 -0.0111 0 31 0.047 1 R.DLYDAGVK.R 5365 5367 9058 518.7614 1035.5082 1035.5349 -0.0267 1 34 0.024 1 R.DLYDAGVKR.K 10286 543.7425 1085.4704 1085.4778 -0.0074 0 45 0.0017 1 K.AYTNFDAER.D 10285 10287 10804 556.2711 1110.5276 1110.5458 -0.0182 0 41 0.0035 1 R.QDIAFAYQR.R 10811 12626 611.7891 1221.5636 1221.5877 -0.0241 0 59 6.4e-005 1 K.TPAQYDASELK.A 12625 12627 12628 12629 12890 622.8103 1243.6061 1243.6156 -0.0095 0 58 8.2e-005 1 R.TNQELQEINR.V 12884 12885 12886 12887 12888

31. P07900|HS90A_HUMAN Mass: 85006 Score: 320 Queries matched: 18 emPAI: 0.47 Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1907 405.6860 809.3574 809.3742 -0.0167 0 27 0.09 1 K.FENLCK.I 2049 408.2512 814.4878 814.5065 -0.0187 0 33 0.036 1 R.ALLFVPR.R 5337 440.2252 878.4359 878.4167 0.0192 0 9 7.9 10 R.EMLQQSK.I 7198 474.7145 947.4144 947.4389 -0.0244 0 15 1.7 1 K.FYEQFSK.N 7201 7989 495.2596 988.5047 988.5627 -0.0580 1 2 41 5 K.IMKDILEK.K 9101 520.2447 1038.4748 1038.4869 -0.0121 0 64 1.9e-005 1 R.YESLTDPSK.L 9103 11515 575.7617 1149.5089 1149.4673 0.0416 0 6 12 10 K.EVSDDEAEEK.E 11584 576.2754 1150.5363 1150.5506 -0.0143 0 22 0.34 1 K.YIDQEELNK.T 1509 618.2831 1234.5516 1234.5942 -0.0426 0 59 0.00023 1 K.DQVANSAFVER.L 12781 12879 621.8360 1241.6574 1241.6979 -0.0405 0 59 7e-005 1 K.ADLINNLGTIAK.S 12880 12881 13415 646.3194 1290.6242 1290.6303 -0.0061 0 49 0.00056 1 R.ELISNSSDALDK.I 13687 656.2675 1310.5204 1310.5626 -0.0422 0 62 2.3e-005 1 K.EDQTEYLEER.R 14143 683.3573 1364.7000 1364.7221 -0.0221 0 64 2e-005 1 R.TLTIVDTGIGMTK.A

32. P15924|DESP_HUMAN Mass: 334021 Score: 304 Queries matched: 62 emPAI: 0.30 Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1659 402.2198 802.4250 802.4225 0.0026 0 23 0.38 1 R.LWDLEK.Q 1857 405.2088 808.4031 808.4330 -0.0299 0 7 11 6 K.YSLVEAK.R 2073 410.2309 818.4472 818.4650 -0.0178 0 23 0.35 1 K.LVFDGLR.K 2083 411.2374 820.4603 820.4807 -0.0203 1 17 1.3 1 K.ILEYKR.Q 2588 416.7270 831.4394 831.4450 -0.0056 0 33 0.032 1 K.VTQLTDR.W 2649 418.7396 835.4645 835.4803 -0.0158 0 11 5.2 3 K.VSYVQLK.E 3750 424.2442 846.4738 846.4083 0.0656 0 17 1.4 1 K.QSLDDAAK.T 3754 4338 431.7537 861.4929 861.4920 0.0009 0 24 0.29 1 K.ISTISSVR.N 4339 431.7554 861.4961 861.4960 0.0001 0 25 0.21 1 R.GLVGIEFK.E 640 434.2314 866.4483 866.4572 -0.0089 0 5 61 1 R.FLSEMLK.S 5639 444.7250 887.4354 887.4348 0.0006 0 28 0.12 1 R.LEDELNR.A 5715 447.2338 892.4530 892.4654 -0.0124 0 32 0.039 1 R.VQYDLQK.A 6110 451.7432 901.4718 901.5120 -0.0402 0 1 57 7 K.LASLEELK.R 6168 453.7232 905.4318 905.4454 -0.0136 0 27 0.13 1 K.STLEAETR.V 6504 458.7736 915.5326 915.5389 -0.0063 1 39 0.0088 1 R.SLKEQAIK.I 6532 459.2445 916.4744 916.5229 -0.0485 1 7 12 9 K.LESEKAIK.E 6545 460.2441 918.4736 918.4811 -0.0075 0 11 5.2 1 K.NFVDPVTK.K 6734 465.7527 929.4908 929.4930 -0.0022 0 27 0.13 1 R.AQIDNLTR.E 6817 466.2596 930.5047 930.5750 -0.0702 1 4 24 5 K.TTLDKLLK.G 7004 470.7956 939.5767 939.5865 -0.0098 0 20 0.47 1 R.SNKPIILR.A 6994 7038 471.7656 941.5166 941.5294 -0.0129 0 54 0.0002 1 R.QVQNLVNK.S 7124 473.2677 944.5209 944.5291 -0.0082 0 27 0.15 1 K.LTVDSAIAR.D 7133 473.7631 945.5116 945.5243 -0.0128 1 17 1.2 1 K.KQVQTSQK.N 7130 7885 492.7539 983.4932 983.5036 -0.0104 0 30 0.049 1 K.NLHSEISGK.R 8186 501.2444 1000.4743 1000.5414 -0.0670 1 3 30 7 R.NQLDRLSR.E 8286 501.7588 1001.5029 1001.5142 -0.0112 0 20 0.7 1 K.VQEQELTR.L 8416 503.2657 1004.5168 1004.5291 -0.0123 0 34 0.027 1 K.FLDQNLQK.Y 8461 504.7363 1007.4581 1007.4560 0.0021 0 14 2.4 1 R.DLIDFDDR.Q 8485 506.7456 1011.4767 1011.4873 -0.0106 0 19 0.57 1 R.LQDTSSYAK.I 8583 509.2596 1016.5046 1016.5502 -0.0456 0 2 41 7 K.ISITEGIER.G 8737 511.7651 1021.5157 1021.5193 -0.0035 0 49 0.00063 1 K.YGDGIQLTR.S 9281 523.2791 1044.5437 1044.5564 -0.0127 0 44 0.0025 1 R.GIVDSITGQR.L 9285 9453 523.7707 1045.5269 1045.5767 -0.0498 1 6 16 3 R.ISTEEAIRK.G 9626 530.2757 1058.5369 1058.5468 -0.0099 0 34 0.021 1 R.SQLQISNNR.T 10009 537.2772 1072.5398 1072.5513 -0.0115 0 28 0.1 1 R.GAGSIAGASASPK.E 10113 538.2892 1074.5639 1074.5669 -0.0030 1 35 0.018 1 R.TVKDQDITR.F 10112 10202 540.3244 1078.6343 1078.5407 0.0937 1 3 23 1 R.LEYDDLRR.G 10180 10204 10747 554.2694 1106.5243 1106.5356 -0.0113 1 7 12 6 K.AEFQEEAKR.R 10739 10740 10931 561.2409 1120.4672 1120.6240 -0.1569 1 7 11 10 K.VSYVQLKER.C 11173 565.2990 1128.5834 1128.6026 -0.0192 0 52 0.00036 1 K.IEVLEEELR.L 11189 566.2525 1130.4904 1130.5469 -0.0565 0 10 4.9 6 R.GIHNSIGDYR.W 11182 11379 570.3302 1138.6459 1138.6597 -0.0139 0 41 0.004 1 R.AELIVQPELK.Y 11492 573.8055 1145.5965 1145.6292 -0.0327 0 31 0.039 1 R.LQSLTENLTK.E 11769 583.2983 1164.5821 1164.5775 0.0046 0 44 0.0022 1 K.IQSQFTDAQK.H 11835 585.7681 1169.5216 1169.5313 -0.0097 0 54 0.00017 1 R.YEVTSGGGGTSR.M 12070 593.8057 1185.5969 1185.6102 -0.0132 1 19 0.69 1 R.RAEENALQQK.A 12549 610.7916 1219.5685 1219.5680 0.0005 0 48 0.00082 1 R.ETQSQLETER.S 13011 627.7980 1253.5814 1253.5928 -0.0114 0 52 0.00028 1 K.AITGFDDPFSGK.T 13291 636.8358 1271.6571 1271.6470 0.0101 1 58 8.4e-005 1 R.RVEEDIQQQK.A 13373 642.3225 1282.6304 1282.5976 0.0328 1 26 0.12 2 K.DM LANFRGSEK.Y 13474 432.5539 1294.6399 1294.6405 -0.0006 1 19 0.57 1 R.LTYEIEDEKR.R 630

33. P63104|1433Z_HUMAN Mass: 27899 Score: 297 Queries matched: 21 emPAI: 0.89 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5647 445.2438 888.4730 888.4916 -0.0186 0 39 0.0087 1 R.VVSSIEQK.T 5648

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995 454.2564 906.4982 906.5174 -0.0192 0 28 0.19 1 R.NLLSVAYK.N 6216 6217 6218 997 11583 576.2665 1150.5185 1150.5506 -0.0321 0 3 24 7 R.YLAEVAAGDDK.K 12981 626.7832 1251.5519 1251.6394 -0.0875 1 10 4.1 4 K.KEMQPTHPIR.L 12982 12984 12986 12987 13308 640.3192 1278.6238 1278.6456 -0.0218 1 80 4.6e-007 1 R.YLAEVAAGDDKK.G 13309 13310 13563 652.8392 1303.6639 1303.6772 -0.0133 0 60 4.9e-005 1 K.FLIPNASQAESK.V 13561 13562 15030 774.8345 1547.6545 1547.7063 -0.0518 0 113 1.8e-010 1 K.SVTEQGAELSNEER.N 15031

34. P14618|KPYM_HUMAN Mass: 58470 Score: 294 Queries matched: 24 emPAI: 0.85 Pyruvate kinase isozymes M1/M2 OS=Homo sapiens GN=PKM2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2748 420.7632 839.5119 839.5229 -0.0110 0 32 0.029 1 R.APIIAVTR.N 2737 2747 2750 6854 467.2541 932.4936 932.5154 -0.0217 0 30 0.062 1 R.GIFPVLCK.D 8000 495.7537 989.4929 989.5029 -0.0101 0 53 0.00032 1 K.GSGTAEVELK.K 8683 510.2556 1018.4967 1018.5083 -0.0116 0 41 0.0055 1 K.GDYPLEAVR.M 8681 8682 1302 8684 10889 559.7939 1117.5732 1117.5979 -0.0247 1 71 4.5e-006 1 K.GSGTAEVELKK.G 11452 571.2949 1140.5752 1140.6026 -0.0274 0 54 0.0002 1 R.GDLGIEIPAEK.V 11422 11435 11448 11449 11450 12284 599.2838 1196.5530 1196.5747 -0.0217 0 39 0.0059 1 K.ITLDNAYMEK.C 12287 599.3114 1196.6083 1196.6401 -0.0318 0 81 4e-007 1 R.LDIDSPPITAR.N 12277 12289 12514 607.2883 1212.5620 1212.5696 -0.0076 0 (33) 0.022 1 K.ITLDNAYM EK.C 14095 680.3477 1358.6808 1358.6976 -0.0168 0 53 0.00027 1 R.NTGIICTIGPASR.S

35. Q5VTE0|EF1A3_HUMAN Mass: 50495 Score: 293 Queries matched: 31 emPAI: 0.53 Putative elongation factor 1-alpha-like 3 OS=Homo sapiens GN=EEF1AL3 PE=5 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2726 420.2242 838.4339 838.4436 -0.0097 0 26 0.11 1 K.EVSTYIK.K 2721 2728 4906 435.7640 869.5135 869.5334 -0.0200 0 27 0.096 1 K.QLIVGVNK.M 751 4688 4692 4846 4853 5039 5093 5722 447.7469 893.4792 893.4858 -0.0066 1 35 0.016 2 R.TIEKFEK.E 5721 6463 457.7755 913.5364 913.5597 -0.0233 0 42 0.0032 1 R.QTVAVGVIK.A 6462 6465 6909 468.7560 935.4975 935.5076 -0.0101 1 20 0.5 1 K.RYEEIVK.E 7527 484.2643 966.5140 966.5386 -0.0245 1 43 0.0024 1 K.EVSTYIKK.I 7529 1213 488.2734 974.5323 974.5437 -0.0114 0 21 2 1 R.LPLQDVYK.I 1211 1212 8819 513.3012 1024.5878 1024.6030 -0.0151 0 67 8.9e-006 1 K.IGGIGTVPVGR.V 8816 8817 8818 8820 8821 8823 10919 560.8028 1119.5910 1119.5924 -0.0014 0 50 0.0006 1 K.STTTGHLIYK.C 10918

Proteins matching the same set of peptides: P68104|EF1A1_HUMAN Mass: 50451 Score: 293 Queries matched: 31 Elongation factor 1-alpha 1 OS=Homo sapiens GN=EEF1A1 PE=1 SV=1

36. P09467|F16P1_HUMAN Mass: 37190 Score: 292 Queries matched: 18 emPAI: 0.62 Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5416 442.1997 882.3847 882.3905 -0.0058 0 39 0.0051 1 R.FVMEEGR.K 5414 5415 11616 579.2846 1156.5546 1156.5764 -0.0218 0 65 1.7e-005 1 K.IYSLNEGYAK.D 11608 11615 11617 11626 12921 417.2002 1248.5787 1248.5921 -0.0135 0 25 0.15 1 R.YVGSMVADVHR.T 12920 14655 727.3238 1452.6331 1452.6885 -0.0554 0 66 1e-005 1 K.DFDPAVTEYIQR.K 14656 14657 15128 543.9228 1628.7465 1628.7642 -0.0177 1 37 0.0087 1 K.STDEPSEKDALQPGR.N 15124 15125 15126 15127

37. Q8N1N4|K2C78_HUMAN Mass: 57629 Score: 288 Queries matched: 57 emPAI: 0.37 Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6176 453.7254 905.4363 905.4607 -0.0244 0 49 0.00081 1 R.FLEQQNK.V 6169 6170 6171 6172 6173 6175 6178 6179 6180 6181 6 7824 490.2566 978.4986 978.5022 -0.0036 0 55 0.00018 1 K.DVDGVFLSK.M 7823 8412 503.2351 1004.4556 1004.4597 -0.0041 0 58 0.0001 1 R.LLEGEECR.M 8396 8397 8398 8399 8400 8401 8402 8403 8404 8405 8539 508.2704 1014.5262 1014.5345 -0.0083 0 41 0.0051 1 K.VDELEAALR.M 8529 10998 562.2755 1122.5364 1122.5557 -0.0192 0 42 0.003 1 K.AEAEALYQTK.Y

38. Q06830|PRDX1_HUMAN Mass: 22324 Score: 276 Queries matched: 34 emPAI: 3.15 Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2067 410.2047 818.3949 818.4134 -0.0184 0 37 0.014 1 R.SVDETLR.L 2066 2068 2069 2070 208 2072 5630 444.7099 887.4051 887.4389 -0.0337 1 29 0.087 1 K.SKEYFSK.Q 5637 5638 6548 460.7406 919.4666 919.5015 -0.0349 0 40 0.0054 1 R.GLFIIDDK.G 6550 6990 470.7326 939.4506 939.4549 -0.0043 0 26 0.12 1 K.DISLSDYK.G 6980 6985 6991 7828 490.7584 979.5023 979.5239 -0.0217 0 33 0.029 1 K.IGHPAPNFK.A 7829 7830 10755 554.2914 1106.5682 1106.5972 -0.0290 0 48 0.00092 1 R.TIAQDYGVLK.A 10754 10756 10757 10758 10759 11744 582.7815 1163.5484 1163.5645 -0.0161 0 31 0.042 1 K.ATAVMPDGQFK.D 12231 598.8044 1195.5942 1195.6237 -0.0296 0 56 0.00013 1 R.LVQAFQFTDK.H 12232 12233 12234 12460 606.3291 1210.6435 1210.6670 -0.0234 0 47 0.00087 1 R.QITVNDLPVGR.S 12457 12458 12459

39. P31025|LCN1_HUMAN Mass: 19409 Score: 272 Queries matched: 28 emPAI: 1.06 Lipocalin-1 OS=Homo sapiens GN=LCN1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5155 436.2505 870.4865 870.5076 -0.0210 0 13 3.2 1 K.HVAYIIR.S 5151 5309 438.7445 875.4744 875.4899 -0.0154 0 46 0.0016 1 K.VTMLISGR.C 5307 5310 5312 5707 446.7445 891.4745 891.4848 -0.0103 0 (26) 0.18 1 K.VTMLISGR.C 5698 5701 5702 5704 5705 5706 5708 12062 593.3298 1184.6451 1184.6765 -0.0313 0 68 1e-005 1 R.GLSTESILIPR.Q 12058 12059 12060 12061 12063 12064 12065 120 13738 661.2986 1320.5826 1320.6197 -0.0371 0 59 5.2e-005 1 K.NNLEALEDFEK.A 13882 446.8753 1337.6041 1337.6099 -0.0058 1 17 0.9 1 K.TDEPGKYTADGGK.H

40. P26038|MOES_HUMAN Mass: 67892 Score: 270 Queries matched: 24 emPAI: 1.47 Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1908 405.7035 809.3925 809.3919 0.0005 0 36 0.012 1 K.SGYLAGDK.L 2566 416.2447 830.4748 830.4359 0.0390 1 14 3.2 9 R.QGNTKQR.I 2638 417.2347 832.4548 832.4694 -0.0146 0 29 0.075 1 K.ESPLLFK.F

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325 419.2006 836.3866 836.4028 -0.0162 0 13 9.2 1 R.NISFNDK.K 5618 444.2458 886.4770 886.4872 -0.0102 0 49 0.00086 1 K.EALLQASR.D 5724 447.7655 893.5164 893.5375 -0.0211 0 10 5.7 2 R.LFFLQVK.E 6497 458.7561 915.4976 915.5138 -0.0161 1 31 0.047 1 K.KVTAQDVR.K 7136 474.2445 946.4745 946.4906 -0.0161 0 41 0.0049 1 R.ISQLEMAR.Q 7477 481.2846 960.5546 960.5644 -0.0098 1 35 0.023 1 R.KESPLLFK.F 7483 482.2441 962.4736 962.4855 -0.0119 0 (31) 0.044 1 R.ISQLEM AR.Q 7516 483.2473 964.4800 964.4978 -0.0178 1 27 0.11 1 R.NISFNDKK.F 7794 488.7752 975.5358 975.5389 -0.0031 0 49 0.00082 1 K.QLFDQVVK.T 7940 494.2499 986.4852 986.5032 -0.0181 0 48 0.001 1 R.ALELEQER.K 7941 7942 9285 523.2804 1044.5463 1044.5563 -0.0100 0 33 0.028 1 K.ALTSELANAR.D 10154 540.2705 1078.5264 1078.5546 -0.0282 0 43 0.0025 1 R.EDAVLEYLK.I 10839 558.8037 1115.5928 1115.6186 -0.0258 1 36 0.012 1 R.LKQIEEQTK.K 12043 591.7836 1181.5527 1181.5869 -0.0343 0 37 0.01 1 K.APDFVFYAPR.L 12393 603.7679 1205.5213 1205.5598 -0.0385 0 47 0.00098 1 K.AQMVQEDLEK.T 12407 12698 616.2936 1230.5727 1230.5840 -0.0113 0 65 1.7e-005 1 K.AQQELEEQTR.R 12734 617.2758 1232.5371 1232.5673 -0.0302 0 60 5e-005 1 K.ESEAVEWQQK.A 14297 463.2267 1386.6582 1386.6851 -0.0269 1 16 0.99 1 K.AQQELEEQTRR.A

41. P02786|TFR1_HUMAN Mass: 85274 Score: 266 Queries matched: 23 emPAI: 0.29 Transferrin receptor protein 1 OS=Homo sapiens GN=TFRC PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1683 403.6963 805.3781 805.3719 0.0063 0 28 0.11 1 K.DGFQPSR.S 1682 1826 404.7028 807.3911 807.3875 0.0036 0 13 2.7 1 R.DLNQYR.A 1825 5168 436.7092 871.4039 871.4188 -0.0149 0 17 1.3 1 R.DAWGPGAAK.S 771 5173 5228 437.2666 872.5186 872.5331 -0.0145 0 19 0.92 1 K.LTVSNVLK.E 5235 6697 465.2710 928.5273 928.4978 0.0296 0 0 57 2 R.LAGTESPVR.E 6693 6908 468.7507 935.4869 935.5076 -0.0207 0 28 0.095 1 K.AVLGTSNFK.V 6910 7424 479.7888 957.5630 957.5859 -0.0228 0 44 0.0024 1 K.SGVGTALLLK.L 7425 10533 548.2737 1094.5328 1094.5244 0.0084 0 59 6.6e-005 1 R.LTTDFGNAEK.T 10532 12344 602.8138 1203.6131 1203.6248 -0.0116 0 43 0.0023 1 K.LLNENSYVPR.E 12345 12530 609.2698 1216.5250 1216.5360 -0.0110 0 25 0.14 1 R.EEPGEDFPAAR.R 12529 13401 644.8368 1287.6589 1287.6670 -0.0081 0 99 6.1e-009 1 K.DSAQNSVIIVDK.N 13400

42. P11142|HSP7C_HUMAN Mass: 71082 Score: 260 Queries matched: 21 emPAI: 0.75 Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1665 402.7198 803.4250 803.4389 -0.0139 0 32 0.054 1 K.ITITNDK.G 1667 4285 429.7270 857.4395 857.4494 -0.0100 0 29 0.1 1 R.GTLDPVEK.A 4282 4286 4287 4300 7102 472.7590 943.5035 943.5161 -0.0126 0 41 0.0057 1 K.VCNPIITK.L 7096 7988 495.2590 988.5034 988.5189 -0.0155 1 36 0.016 1 R.LSKEDIER.M 7991 8078 497.2494 992.4842 992.5178 -0.0336 0 41 0.0045 1 K.EIAEAYLGK.T 8585 509.2790 1016.5435 1016.5614 -0.0179 1 57 0.00012 1 K.ITITNDKGR.L 8588 12032 590.8039 1179.5933 1179.6135 -0.0202 1 37 0.011 1 K.VQVEYKGETK.S 12318 600.3244 1198.6342 1198.6670 -0.0328 0 59 5.9e-005 1 K.DAGTIAGLNVLR.I 12671 614.7982 1227.5819 1227.6207 -0.0388 0 76 1.4e-006 1 K.VEIIANDQGNR.T 12673 13727 660.2771 1318.5396 1318.5863 -0.0468 0 36 0.012 1 K.NSLESYAFNM K.A 14822 744.3423 1486.6700 1486.6940 -0.0240 0 52 0.00029 1 R.TTPSYVAFTDTER.L 15175 564.5704 1690.6893 1690.7183 -0.0290 0 15 0.93 1 K.STAGDTHLGGEDFDNR.M

43. P61626|LYSC_HUMAN Mass: 16982 Score: 253 Queries matched: 20 emPAI: 1.28 Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2399 414.1822 826.3499 826.3643 -0.0144 0 43 0.0022 1 R.LGMDGYR.G 2394 2395 2396 2397 2398 2400 2401 2403 2432 6239 455.6956 909.3767 909.4015 -0.0248 0 42 0.0035 1 R.QYVQGCGV.- 7034 471.6798 941.3450 941.3701 -0.0252 0 27 0.078 1 R.YWCNDGK.T 7033 9107 520.2841 1038.5536 1038.5934 -0.0398 1 16 1.4 1 R.VVRDPQGIR.A 9105 9106 9108 14424 700.8009 1399.5873 1399.6732 -0.0858 0 76 9.9e-007 1 R.STDYGIFQINSR.Y 14425 14426

44. P07195|LDHB_HUMAN Mass: 36900 Score: 249 Queries matched: 14 emPAI: 0.34 L-lactate dehydrogenase B chain OS=Homo sapiens GN=LDHB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6332 457.2035 912.3924 912.5757 -0.1832 0 19 0.7 2 K.IVVVTAGVR.Q 6324 6327 1017 1028 6451 7431 480.2666 958.5186 958.5447 -0.0261 0 55 0.00021 1 R.GLTSVINQK.L 7430 12915 624.7895 1247.5644 1247.5928 -0.0284 0 67 1e-005 1 R.VIGSGCNLDSAR.F 12913 12914 12916 14915 504.2618 1509.7637 1509.7675 -0.0037 1 55 0.00013 1 K.IVADKDYSVTANSK.I 14916

45. P52566|GDIR2_HUMAN Mass: 23031 Score: 243 Queries matched: 13 emPAI: 0.85 Rho GDP-dissociation inhibitor 2 OS=Homo sapiens GN=ARHGDIB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4026 428.2463 854.4781 854.4974 -0.0193 0 42 0.0028 1 K.APNVVVTR.L 4016 4023 4039 4040 4043 7518 483.7354 965.4563 965.4719 -0.0156 0 36 0.013 1 K.YVQHTYR.T 13692 656.3351 1310.6556 1310.7082 -0.0526 0 68 7.8e-006 1 K.TLLGDGPVVTDPK.A 13691 13693 13694 13695 15225 647.2638 1938.7697 1938.7967 -0.0270 0 29 0.022 1 K.APEPHVEEDDDDELDSK.L

46. P04083|ANXA1_HUMAN Mass: 38918 Score: 232 Queries matched: 32 emPAI: 0.44 Annexin A1 OS=Homo sapiens GN=ANXA1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6222 454.7187 907.4229 907.4399 -0.0170 0 27 0.097 1 R.ALYEAGER.R 6221 6224 1044 458.7415 915.4684 915.4848 -0.0163 0 38 0.0096 1 K.ILVALCGGN.- 6489 6500 6502 6503 6506 6507 6510 6511 6514 651 12509 607.2542 1212.4938 1212.5259 -0.0321 0 52 0.00026 1 K.DITSDTSGDFR.N 12510 12511 12512 13108 631.7799 1261.5453 1261.5939 -0.0485 0 72 3.1e-006 1 K.TPAQFDADELR.A 13117 13123

47. P52790|HXK3_HUMAN Mass: 100616 Score: 230 Queries matched: 14 emPAI: 0.24

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Hexokinase-3 OS=Homo sapiens GN=HK3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7249 477.2565 952.4984 952.5090 -0.0106 0 47 0.00091 1 R.GQASPAPAVR.M 8841 514.7549 1027.4952 1027.5047 -0.0095 0 29 0.069 1 R.NVAGVPGDSGR.M 9217 523.2668 1044.5191 1044.5676 -0.0485 1 5 19 9 K.GLRGEASSLR.M 9213 9231 9241 9257 9294 523.2831 1044.5517 1044.5750 -0.0232 0 (47) 0.001 1 R.GVAMVTAVAAR.L 9547 525.7860 1049.5574 1049.5869 -0.0296 0 48 0.00092 1 R.FSSLVAATVR.E 9705 531.2849 1060.5553 1060.5699 -0.0146 0 57 0.0001 1 R.GVAM VTAVAAR.L 10308 544.7870 1087.5594 1087.5808 -0.0214 0 90 5.5e-008 1 K.GAALVTAVACR.L 14653 724.8421 1447.6696 1447.6943 -0.0247 0 88 7.4e-008 1 R.FDASVDQASINPGK.Q 15190 583.9325 1748.7758 1748.9196 -0.1438 0 5 11 1 R.GLEELAVSVGVDGTLYK.L 15191

48. P06733|ENOA_HUMAN Mass: 47481 Score: 218 Queries matched: 33 emPAI: 0.58 Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1599 400.6902 799.3659 799.3752 -0.0093 0 22 0.4 1 K.YDLDFK.S 1610 401.2294 800.4443 800.4643 -0.0201 0 50 0.00074 1 K.EGLELLK.T 1614 1617 1618 1623 1695 403.7227 805.4308 805.4446 -0.0138 0 15 2.1 4 K.YNQLLR.I 1697 6065 450.2761 898.5377 898.5488 -0.0110 0 43 0.0023 1 K.TIAPALVSK.K 6057 6061 6062 6063 6064 6066 6067 6148 452.7332 903.4519 903.4549 -0.0030 0 40 0.0066 1 R.IEEELGSK.A 6141 6142 6143 6144 6145 6146 6147 7434 480.7492 959.4839 959.4924 -0.0084 0 52 0.00045 1 K.LNVTEQEK.I 7432 8459 504.2508 1006.4870 1006.4940 -0.0069 0 48 0.00087 1 K.SCNCLLLK.V 8457 1282 10307 544.7856 1087.5566 1087.5873 -0.0307 1 51 0.00046 1 K.KLNVTEQEK.I 10309 10310 11459 572.3029 1142.5913 1142.6084 -0.0171 0 1 43 6 R.IGAEVYHNLK.N

49. P60174|TPIS_HUMAN Mass: 26938 Score: 212 Queries matched: 10 emPAI: 0.93 Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3795 425.7287 849.4429 849.4596 -0.0168 0 32 0.045 1 K.VVFEQTK.V 3798 3799 11370 569.2890 1136.5635 1136.5648 -0.0013 0 34 0.022 1 K.IAVAAQNCYK.V 12742 617.7914 1233.5682 1233.5949 -0.0267 0 92 3e-008 1 K.SNVSDAVAQSTR.I 12743 13100 630.8136 1259.6126 1259.6357 -0.0231 1 23 0.25 1 K.LDEREAGITEK.V 13750 663.8284 1325.6421 1325.6649 -0.0228 0 76 1.2e-006 1 R.IIYGGSVTGATCK.E 14700 489.5753 1465.7040 1465.7161 -0.0121 0 21 0.33 1 K.TATPQQAQEVHEK.L 14699

50. P25311|ZA2G_HUMAN Mass: 34079 Score: 203 Queries matched: 11 emPAI: 0.23 Zinc-alpha-2-glycoprotein OS=Homo sapiens GN=AZGP1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10055 537.2991 1072.5836 1072.5625 0.0211 1 13 2.9 4 K.QDSQLQKAR.E 11133 564.2762 1126.5378 1126.5618 -0.0240 0 50 0.00051 1 R.AGEVQEPELR.G 11125 11128 11131 11132 11134 11135 11136 1113 14654 726.3242 1450.6338 1450.6762 -0.0424 0 72 2.5e-006 1 K.AYLEEECPATLR.K

51. Q01469|FABP5_HUMAN Mass: 15497 Score: 184 Queries matched: 11 emPAI: 0.96 Fatty acid-binding protein, epidermal OS=Homo sapiens GN=FABP5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6678 464.2795 926.5445 926.5549 -0.0104 0 40 0.0056 1 K.ELGVGIALR.K 6666 6669 6672 6674 8778 513.2191 1024.4236 1024.4462 -0.0226 0 73 2.3e-006 1 K.FEETTADGR.K 8776 8782 8808 13287 636.2708 1270.5271 1270.5864 -0.0593 0 58 6.4e-005 1 K.TTQFSCTLGEK.F 13288

52. P31146|COR1A_HUMAN Mass: 51678 Score: 180 Queries matched: 11 emPAI: 0.63 Coronin-1A OS=Homo sapiens GN=CORO1A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2648 418.7237 835.4328 835.4440 -0.0112 0 23 0.34 1 R.AVFVSEGK.I 5723 447.7487 893.4828 893.4971 -0.0143 0 25 0.18 1 K.ILTTGFSR.M 5720 6532 459.2445 916.4744 916.4865 -0.0122 0 24 0.29 1 R.LEETVQAK.- 7433 480.7423 959.4699 959.5076 -0.0377 0 39 0.0082 1 R.QVALWDTK.H 8829 513.8053 1025.5959 1025.6121 -0.0161 0 57 8.6e-005 1 R.DAGPLLISLK.D 8830 11375 569.7413 1137.4681 1137.4907 -0.0226 0 45 0.0015 1 R.DGGLICTSCR.D 11599 578.2245 1154.4344 1154.4662 -0.0318 0 57 7.2e-005 1 K.ADQCYEDVR.V 11633 579.3155 1156.6165 1156.6452 -0.0287 0 43 0.0025 1 K.LQATVQELQK.R 14889 751.8420 1501.6694 1501.7009 -0.0315 0 54 0.00017 1 R.AAPEASGTPSSDAVSR.L

53. P54652|HSP72_HUMAN Mass: 70263 Score: 179 Queries matched: 16 emPAI: 0.29 Heat shock-related 70 kDa protein 2 OS=Homo sapiens GN=HSPA2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1665 402.7198 803.4250 803.4389 -0.0139 0 32 0.054 1 K.ITITNDK.G 1667 4335 431.6849 861.3552 861.4014 -0.0462 0 5 22 5 R.MVQEAER.Y 6084 450.7700 899.5254 899.5076 0.0177 0 9 7.3 1 R.VVSEGGKPK.V 942 8585 509.2790 1016.5435 1016.5614 -0.0179 1 57 0.00012 1 K.ITITNDKGR.L 8588 10453 546.2601 1090.5057 1090.4639 0.0418 1 13 2.8 1 K.SEDEANRDR.V 10454 12032 590.8039 1179.5933 1179.6135 -0.0202 1 37 0.011 1 K.VQVEYKGETK.T 12399 603.7742 1205.5339 1205.5750 -0.0412 0 3 25 9 R.MVSHLAEEFK.R 12671 614.7982 1227.5819 1227.6207 -0.0388 0 76 1.4e-006 1 K.VEIIANDQGNR.T 12673 13748 442.5763 1324.7072 1324.6696 0.0375 1 4 19 7 K.MKEIAEAYLGGK.V 14822 744.3423 1486.6700 1486.6940 -0.0240 0 52 0.00029 1 R.TTPSYVAFTDTER.L 15175 564.5704 1690.6893 1690.7183 -0.0290 0 15 0.93 1 K.STAGDTHLGGEDFDNR.M

54. P08107|HSP71_HUMAN Mass: 70294 Score: 171 Queries matched: 15 emPAI: 0.23 Heat shock 70 kDa protein 1 OS=Homo sapiens GN=HSPA1A PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1607 401.2095 800.4044 800.4140 -0.0096 0 25 0.21 1 K.DNNLLGR.F 1665 402.7198 803.4250 803.4389 -0.0139 0 32 0.054 1 K.ITITNDK.G 1667 4324 430.7458 859.4771 859.4512 0.0259 1 9 8.7 9 K.DISQNKR.A 6107 451.7395 901.4644 901.4756 -0.0113 0 17 1.4 1 R.STLEPVEK.A 8354 502.2746 1002.5346 1002.5345 0.0001 1 22 0.36 1 R.LSKEEIER.M

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8585 509.2790 1016.5435 1016.5614 -0.0179 1 57 0.00012 1 K.ITITNDKGR.L 8588 11369 569.2734 1136.5322 1136.5462 -0.0140 1 23 0.25 1 K.YKAEDEVQR.E 12267 599.2610 1196.5074 1196.6877 -0.1803 0 3 24 6 K.DAGVIAGLNVLR.I 12342 602.7612 1203.5079 1203.5255 -0.0176 0 8 8.7 1 K.GGSGSGPTIEEVD.- 12671 614.7982 1227.5819 1227.6207 -0.0388 0 76 1.4e-006 1 K.VEIIANDQGNR.T 12673 12876 621.7780 1241.5414 1241.6979 -0.1565 1 4 21 7 R.STLEPVEKALR.D 14822 744.3423 1486.6700 1486.6940 -0.0240 0 52 0.00029 1 R.TTPSYVAFTDTER.L

55. P23528|COF1_HUMAN Mass: 18719 Score: 170 Queries matched: 10 emPAI: 0.21 Cofilin-1 OS=Homo sapiens GN=CFL1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6473 458.2453 914.4760 914.5073 -0.0312 0 26 0.16 1 K.NIILEEGK.E 1041 13591 437.2169 1308.6288 1308.6748 -0.0459 1 17 1 1 K.AVLFCLSEDKK.N 13593 13844 669.2933 1336.5721 1336.6187 -0.0466 0 65 1.4e-005 1 R.YALYDATYETK.E 13841 13842 13843 13845 13846

56. P25774|CATS_HUMAN Mass: 38099 Score: 170 Queries matched: 6 emPAI: 0.33 Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7262 478.7491 955.4837 955.5087 -0.0250 0 59 7.5e-005 1 K.GPVSVGVDAR.H 7261 7263 7264 8126 499.7330 997.4514 997.4869 -0.0355 0 30 0.052 1 K.YTELPYGR.E 12522 608.2653 1214.5161 1214.5455 -0.0294 0 72 3.5e-006 1 K.GIDSDASYPYK.A

57. P07737|PROF1_HUMAN Mass: 15216 Score: 170 Queries matched: 8 emPAI: 2.13 Profilin-1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5279 437.7638 873.5130 873.5358 -0.0227 0 38 0.01 1 K.TLVLLMGK.E 8767 512.2687 1022.5228 1022.5509 -0.0281 0 49 0.00062 1 K.EGVHGGLINK.K 8768 11586 576.3091 1150.6036 1150.6458 -0.0422 1 48 0.00087 1 K.EGVHGGLINKK.C 12515 607.2906 1212.5666 1212.6139 -0.0473 0 44 0.0018 1 K.DSPSVWAAVPGK.T 12513 14226 690.3293 1378.6441 1378.7093 -0.0652 0 71 3.8e-006 1 K.STGGAPTFNVTVTK.T 14227

58. Q14019|COTL1_HUMAN Mass: 16049 Score: 169 Queries matched: 15 emPAI: 1.95 Coactosin-like protein OS=Homo sapiens GN=COTL1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1693 403.7184 805.4223 805.4446 -0.0223 0 57 0.00014 1 R.AAYNLVR.D 1692 1694 1696 1698 4346 433.2103 864.4060 864.4341 -0.0282 0 5 19 1 K.EFVISDR.K 4345 4347 6897 467.7386 933.4626 933.4920 -0.0293 0 47 0.0013 1 K.EVVQNFAK.E 6896 6898 6899 8082 497.2526 992.4906 992.5291 -0.0384 1 28 0.082 1 K.EFVISDRK.E 8736 511.7454 1021.4762 1021.4968 -0.0206 0 40 0.0058 1 K.ELEEDFIK.S 11516 575.7804 1149.5462 1149.5917 -0.0455 1 56 0.00012 1 R.KELEEDFIK.S

59. P06703|S10A6_HUMAN Mass: 10230 Score: 169 Queries matched: 10 emPAI: 1.71 Protein S100-A6 OS=Homo sapiens GN=S100A6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5688 446.2055 890.3964 890.4167 -0.0204 0 (31) 0.057 1 R.LMEDLDR.N 6210 454.2071 906.3996 906.4117 -0.0120 0 40 0.006 1 R.LMEDLDR.N 6208 6209 6468 458.2402 914.4659 914.4821 -0.0162 0 59 8.7e-005 1 K.LQDAEIAR.L 6466 6467 6469 6470 8182 500.7969 999.5793 999.5964 -0.0171 1 27 0.12 1 K.ELKELIQK.E

60. P04406|G3P_HUMAN Mass: 36201 Score: 168 Queries matched: 23 emPAI: 0.49 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1674 403.2110 804.4074 804.4243 -0.0168 0 39 0.0087 1 K.VGVNGFGR.I 1673 1675 1676 1679 1921 406.2106 810.4066 810.4058 0.0008 0 10 5.2 1 K.LTGMAFR.V 1917 2475 415.2110 828.4073 828.4341 -0.0268 0 3 31 7 K.QASEGPLK.G 288 4644 435.2514 868.4882 868.5018 -0.0136 0 26 0.11 1 K.VIPELNGK.L 4531 4593 4608 6229 455.2067 908.3989 908.4828 -0.0839 0 5 16 9 K.AGAHLQGGAK.R 6236 9864 533.2598 1064.5050 1064.5839 -0.0789 1 1 38 7 K.AGAHLQGGAKR.V 11726 582.3113 1162.6080 1162.6458 -0.0378 1 6 13 1 R.LVTRAAFNSGK.V 14438 706.3706 1410.7266 1410.7831 -0.0564 0 40 0.0046 1 R.GALQNIIPASTGAAK.A 14439 14440 14441 14443 14992 765.8858 1529.7571 1529.7872 -0.0301 0 85 1.1e-007 1 R.VPTANVSVVDLTCR.L

61. P10599|THIO_HUMAN Mass: 12015 Score: 156 Queries matched: 13 emPAI: 1.36 Thioredoxin OS=Homo sapiens GN=TXN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6223 454.7194 907.4242 907.4399 -0.0157 0 58 8.7e-005 1 K.VGEFSGANK.E 6219 6225 8279 501.2885 1000.5624 1000.5441 0.0183 0 1 51 1 K.LEATINELV.- 11761 583.2863 1164.5581 1164.5775 -0.0194 1 56 0.00011 1 K.VGEFSGANKEK.L 13821 668.8018 1335.5891 1335.6306 -0.0415 0 66 9.9e-006 1 K.TAFQEALDAAGDK.L 13827 13828 13833 13836 13837 13839 13840

62. P27348|1433T_HUMAN Mass: 28032 Score: 150 Queries matched: 18 emPAI: 0.29 14-3-3 protein theta OS=Homo sapiens GN=YWHAQ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6133 452.2562 902.4979 902.5073 -0.0094 0 48 0.00099 1 R.VISSIEQK.T 6127 6130 6132 947 995 454.2564 906.4982 906.5174 -0.0192 0 28 0.19 1 R.NLLSVAYK.N 6216 6217 6218 997 7986 495.2546 988.4946 988.5189 -0.0243 1 9 7.1 2 R.EKVESELR.S 12981 626.7832 1251.5519 1251.6394 -0.0875 1 10 4.1 4 K.KEMQPTHPIR.L 12982 12984 12986 12987 14994 766.8458 1531.6770 1531.7114 -0.0344 0 94 1.7e-008 1 K.AVTEQGAELSNEER.N 14993

63. P31949|S10AB_HUMAN Mass: 11847 Score: 148 Queries matched: 9 emPAI: 1.37 Protein S100-A11 OS=Homo sapiens GN=S100A11 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8676 510.2382 1018.4619 1018.4931 -0.0312 0 49 0.00074 1 K.ISSPTETER.C 8677 8678 8679 8680

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9640 530.7451 1059.4757 1059.4873 -0.0115 0 42 0.0037 1 K.DGYNYTLSK.T 9637 9639 11444 571.2778 1140.5411 1140.5887 -0.0476 1 33 0.028 1 K.NQKDPGVLDR.M

64. O00299|CLIC1_HUMAN Mass: 27248 Score: 146 Queries matched: 6 emPAI: 0.69 Chloride intracellular channel protein 1 OS=Homo sapiens GN=CLIC1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7301 479.2305 956.4465 956.4715 -0.0250 0 39 0.0072 1 R.YLSNAYAR.E 7302 10150 539.7506 1077.4867 1077.5026 -0.0159 0 27 0.12 1 K.IGNCPFSQR.L 13313 641.3246 1280.6347 1280.6613 -0.0265 0 59 5.6e-005 1 K.GVTFNVTTVDTK.R 13807 664.8093 1327.6040 1327.6368 -0.0328 0 55 0.00015 1 K.NSNPALNDNLEK.G 13806

65. P52209|6PGD_HUMAN Mass: 53619 Score: 145 Queries matched: 18 emPAI: 0.31 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1632 401.2477 800.4808 800.4756 0.0052 0 25 0.22 1 K.VVGAQSLK.E 1621 1907 405.6860 809.3574 809.3556 0.0019 0 8 7.9 8 K.FQDTDGK.H 7212 474.7700 947.5255 947.5440 -0.0185 0 21 0.5 2 K.TIFQGIAAK.V 7868 492.7301 983.4456 983.4713 -0.0256 1 11 3.7 7 K.FQFDGDKK.S 10942 561.2649 1120.5151 1120.5400 -0.0249 0 38 0.0096 1 K.VDDFLANEAK.G 10926 10932 10936 10939 10941 10943 10950 1095 11354 568.7830 1135.5514 1135.5332 0.0182 0 36 0.012 1 R.YGPSLM PGGNK.E 12104 596.7805 1191.5465 1191.5772 -0.0307 0 68 8.1e-006 1 K.AGQAVDDFIEK.L 12105 12106

66. P62988|UBIQ_HUMAN Mass: 8560 Score: 144 Queries matched: 25 emPAI: 3.77 Ubiquitin OS=Homo sapiens GN=RPS27A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9102 520.2523 1038.4901 1038.5094 -0.0193 0 25 0.17 1 K.EGIPPDQQR.L 9105 9106 9897 534.3062 1066.5978 1066.6135 -0.0157 0 49 0.00065 1 K.ESTLHLVLR.L 10232 541.2654 1080.5163 1080.5451 -0.0288 0 48 0.00078 1 R.TLSDYNIQK.E 10226 10227 10228 10229 10230 10231 10233 10234 14948 508.5863 1522.7372 1522.7740 -0.0368 1 38 0.0066 1 K.IQDKEGIPPDQQR.L 14949 14950 14951 14952 14953

67. P40925|MDHC_HUMAN Mass: 36631 Score: 143 Queries matched: 10 emPAI: 0.34 Malate dehydrogenase, cytoplasmic OS=Homo sapiens GN=MDH1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2074 410.2402 818.4659 818.5014 -0.0355 1 15 2.2 3 K.ANVKIFK.S 2996 421.7452 841.4759 841.5385 -0.0626 1 0 50 5 R.AKAQIALK.L 6491 458.7468 915.4789 915.5025 -0.0236 0 57 0.00012 1 K.LGVTANDVK.N 6486 6487 6490 8826 513.7285 1025.4424 1025.4600 -0.0176 0 38 0.0079 1 K.ENFSCLTR.L 8825 11746 582.7945 1163.5745 1163.5935 -0.0190 0 55 0.00016 1 K.GEFVTTVQQR.G 11745

68. P61981|1433G_HUMAN Mass: 28456 Score: 143 Queries matched: 12 emPAI: 0.28 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6133 452.2562 902.4979 902.5073 -0.0094 0 48 0.00099 1 R.VISSIEQK.T 6127 6130 6132 947 995 454.2564 906.4982 906.5174 -0.0192 0 28 0.19 1 R.NLLSVAYK.N 6216 6217 6218 997 10213 540.7645 1079.5145 1079.5499 -0.0353 0 64 1.8e-005 1 R.YLAEVATGEK.R 10214

69. P00558|PGK1_HUMAN Mass: 44985 Score: 139 Queries matched: 17 emPAI: 0.90 Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1858 405.2097 808.4048 808.4079 -0.0031 0 42 0.0038 1 K.YAEAVTR.A 1856 1857 1890 5448 442.7229 883.4312 883.4439 -0.0128 0 39 0.0065 1 K.ELNYFAK.A 5445 5451 6149 452.7364 903.4583 903.4735 -0.0153 0 18 1.1 1 K.ALMDEVVK.A 6593 462.7103 923.4060 923.4171 -0.0111 0 32 0.032 1 K.FCLDNGAK.S 7216 475.2331 948.4517 948.4739 -0.0222 0 25 0.18 1 R.VDFNVPMK.N 7515 483.2358 964.4569 964.4688 -0.0119 0 (20) 0.63 1 R.VDFNVPM K.N 7663 487.7253 973.4361 973.4505 -0.0144 0 52 0.00045 1 R.FHVEEEGK.G 8951 516.7327 1031.4509 1031.4594 -0.0085 0 46 0.0015 1 K.DCVGPEVEK.A 8950 10539 549.3135 1096.6124 1096.6128 -0.0004 0 14 2 1 K.VLPGVDALSNI.- 12933 625.3345 1248.6544 1248.6747 -0.0203 1 3 26 1 -.MSLSNKLTLDK.L 12954

70. P62258|1433E_HUMAN Mass: 29326 Score: 138 Queries matched: 7 emPAI: 0.13 14-3-3 protein epsilon OS=Homo sapiens GN=YWHAE PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 995 454.2564 906.4982 906.5174 -0.0192 0 28 0.19 1 R.NLLSVAYK.N 6216 6217 6218 997 12125 597.7850 1193.5554 1193.5928 -0.0374 0 92 3.4e-008 1 K.EAAENSLVAYK.A 12129

71. P32119|PRDX2_HUMAN Mass: 22049 Score: 138 Queries matched: 11 emPAI: 0.61 Peroxiredoxin-2 OS=Homo sapiens GN=PRDX2 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 581 431.7417 861.4688 861.4960 -0.0272 0 15 2.2 1 R.GLFIIDGK.G 6594 462.7145 923.4144 923.4348 -0.0204 0 59 5.8e-005 1 K.TDEGIAYR.G 6595 7818 489.7550 977.4953 977.5182 -0.0229 0 31 0.042 1 K.ATAVVDGAFK.E 7816 7817 12460 606.3291 1210.6435 1210.6670 -0.0234 0 47 0.00087 1 R.QITVNDLPVGR.S 12457 12458 12459 14955 510.2351 1527.6836 1527.8158 -0.1321 1 0 36 2 M.ASGNARIGKPAPDFK.A

72. P09382|LEG1_HUMAN Mass: 15048 Score: 134 Queries matched: 11 emPAI: 2.97 Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5323 439.2466 876.4786 876.5069 -0.0283 0 31 0.047 1 K.SFVLNLGK.D 5324 5325 7534 484.7309 967.4472 967.4651 -0.0179 0 35 0.016 1 K.LPDGYEFK.F 7533 1348 521.2676 1040.5206 1040.5614 -0.0408 1 30 0.18 1 R.VRGEVAPDAK.S 9139 10139 538.7168 1075.4190 1075.4683 -0.0492 0 47 0.00095 1 K.DGGAWGTEQR.E 14815 496.2221 1485.6445 1485.6783 -0.0338 0 57 8e-005 1 K.DSNNLCLHFNPR.F 14814

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15148 549.9108 1646.7106 1646.7471 -0.0365 0 22 0.23 1 R.FNAHGDANTIVCNSK.D

73. P29401|TKT_HUMAN Mass: 68519 Score: 131 Queries matched: 19 emPAI: 0.37 Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2082 411.2254 820.4362 820.4443 -0.0081 0 23 0.33 1 K.AYGQALAK.L 3664 422.2295 842.4445 842.4610 -0.0165 0 32 0.044 1 R.DAIAQAVR.G 6478 458.2766 914.5386 914.5549 -0.0163 1 34 0.026 1 R.KLILDSAR.A 6479 6494 458.7522 915.4899 915.5025 -0.0126 0 46 0.0017 1 K.AVELAANTK.G 1043 6482 6483 6484 6487 6488 6919 469.7256 937.4366 937.4579 -0.0213 0 13 2.7 1 R.M PSLPSYK.V 7043 471.7840 941.5535 941.5545 -0.0011 0 16 1.4 1 R.SGKPAELLK.M 7042 7122 473.2630 944.5115 944.5179 -0.0064 0 49 0.00091 1 R.IIALDGDTK.N 7123 7222 475.2663 948.5180 948.5392 -0.0212 1 45 0.0019 1 R.KAYGQALAK.L 7819 489.7810 977.5474 977.5658 -0.0184 0 30 0.064 1 K.HQPTAIIAK.T 13464 432.2276 1293.6611 1293.7768 -0.1157 1 1 42 1 R.VPRSGKPAELLK.M

74. P18206|VINC_HUMAN Mass: 124292 Score: 130 Queries matched: 36 emPAI: 0.19 Vinculin OS=Homo sapiens GN=VCL PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1661 402.2208 802.4271 802.4371 -0.0100 0 11 5.4 1 R.ALIQCAK.D 1666 402.7249 803.4353 803.4389 -0.0035 0 24 0.28 1 R.ALASIDSK.L 2635 417.1996 832.3846 832.4113 -0.0267 0 19 0.87 1 K.VGELCAGK.E 5173 436.7445 871.4745 871.4763 -0.0018 0 35 0.019 1 K.GNDIIAAAK.R 5214 437.2409 872.4673 872.4603 0.0069 0 10 7.5 1 R.QILDEAGK.V 5389 440.7245 879.4344 879.4450 -0.0107 0 30 0.058 1 R.TDAGFTLR.W 6327 457.1984 912.3823 912.5141 -0.1317 0 6 14 2 R.AVANSRPAK.A 6320 6330 6331 6336 1018 6408 6435 6437 6451 6921 469.7353 937.4560 937.4505 0.0055 0 21 0.41 1 R.DYLIDGSR.G 8183 500.7992 999.5839 999.5964 -0.0125 0 21 0.45 1 R.IPTISTQLK.I 8189 501.2643 1000.5141 1000.5189 -0.0048 0 26 0.15 1 K.NQGIEEALK.N 10082 537.7983 1073.5821 1073.4890 0.0931 0 6 15 5 R.AANFENHSGK.L 10891 559.8054 1117.5963 1117.5979 -0.0016 0 56 0.00015 1 K.STVEGIQASVK.T 11775 584.3327 1166.6508 1166.5576 0.0932 0 8 6.9 1 R.LANVMMGPYR.Q 11782 11793 11803 584.3444 1166.6742 1166.5576 0.1166 0 (1) 41 7 R.LANVMMGPYR.Q 11837 585.8183 1169.6220 1169.6404 -0.0184 0 43 0.0021 1 R.ELTPQVVSAAR.I 13281 635.3280 1268.6414 1268.6725 -0.0310 0 67 8.6e-006 1 K.AVAGNISDPGLQK.S 13573 436.8754 1307.6042 1307.6279 -0.0237 0 2 31 5 K.MTGLVDEAIDTK.S 13578 13579 13582 13583 13584 13585 13918 670.8299 1339.6453 1339.6410 0.0043 1 3 24 8 K.RMALLMAEMSR.L 13971 673.3247 1344.6349 1344.6343 0.0006 1 3 27 9 K.IAELCDDPKER.D

75. P36222|CH3L1_HUMAN Mass: 42998 Score: 128 Queries matched: 5 emPAI: 0.29 Chitinase-3-like protein 1 OS=Homo sapiens GN=CHI3L1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5304 438.7253 875.4361 875.4461 -0.0099 0 4 30 8 K.IASNTQSR.R 6138 452.2667 902.5189 902.5225 -0.0036 0 23 0.31 1 R.FPLTNAIK.D 12456 606.3116 1210.6087 1210.6081 0.0006 0 56 0.00012 1 K.VTIDSSYDIAK.I 12533 609.3343 1216.6541 1216.6816 -0.0275 0 50 0.00047 1 R.ILGQQVPYATK.G 14556 719.7907 1437.5668 1437.5831 -0.0163 0 78 4.9e-007 1 R.EGDGSCFPDALDR.F

76. P05109|S10A8_HUMAN Mass: 10885 Score: 128 Queries matched: 11 emPAI: 1.56 Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2087 411.7074 821.4002 821.4072 -0.0070 0 30 0.058 1 K.GADVWFK.E 2086 5337 440.2252 878.4359 878.4419 -0.0060 0 22 0.35 1 -.MLTELEK.A 7482 482.2302 962.4459 962.4722 -0.0263 0 30 0.06 1 K.GNFHAVYR.D 13290 424.8896 1271.6471 1271.6874 -0.0403 0 31 0.04 1 K.ALNSIIDVYHK.Y 13292 14502 711.3333 1420.6520 1420.7020 -0.0500 0 70 4.4e-006 1 K.LLETECPQYIR.K 14501 14506 14509 14510

77. Q04917|1433F_HUMAN Mass: 28372 Score: 126 Queries matched: 18 emPAI: 0.28 14-3-3 protein eta OS=Homo sapiens GN=YWHAH PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6133 452.2562 902.4979 902.5073 -0.0094 0 48 0.00099 1 R.VISSIEQK.T 6127 6130 6132 947 995 454.2564 906.4982 906.5174 -0.0192 0 28 0.19 1 R.NLLSVAYK.N 6216 6217 6218 997 9892 533.7586 1065.5027 1065.5342 -0.0315 0 65 1.7e-005 1 R.YLAEVASGEK.K 9894 12124 597.7842 1193.5538 1193.6292 -0.0753 1 3 27 8 R.YLAEVASGEKK.N 12981 626.7832 1251.5519 1251.6030 -0.0511 0 10 4.1 4 K.EQMQPTHPIR.L 12982 12983 12986 12987

78. Q5D862|FILA2_HUMAN Mass: 249296 Score: 123 Queries matched: 7 emPAI: 0.03 Filaggrin-2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2647 418.2444 834.4743 834.4963 -0.0220 0 4 22 6 K.ELHPVLK.N 3987 427.2194 852.4243 852.3833 0.0410 0 0 47 6 K.LTMACNK.V 6683 464.7319 927.4492 927.4563 -0.0071 0 18 1 1 R.HGSSQVWK.H 7561 486.2421 970.4696 970.4832 -0.0136 0 44 0.0023 1 R.HGSSSVELR.E 13731 660.7707 1319.5269 1319.5630 -0.0361 0 67 7.8e-006 1 R.FSNSSSSNEFSK.C 13733 14941 761.3452 1520.6759 1520.7141 -0.0381 1 6 11 7 K.QDGECGTLSKGELK.E

79. Q9Y490|TLN1_HUMAN Mass: 271766 Score: 121 Queries matched: 30 emPAI: 0.10 Talin-1 OS=Homo sapiens GN=TLN1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1651 401.7000 801.3854 801.3981 -0.0126 0 14 3.1 4 R.DVDNALR.A 1653 401.7292 801.4439 801.4596 -0.0157 0 22 0.47 1 K.ILADATAK.M 1660 402.2204 802.4263 802.4436 -0.0173 0 8 10 1 K.VLVEDTK.V 1674 403.2110 804.4074 804.4164 -0.0089 0 12 4 3 R.AIADMLR.A 1675 1676 1679 4306 429.7542 857.4938 857.4971 -0.0033 0 8 10 1 R.AQVVSNLK.G 4308 430.2326 858.4507 858.5174 -0.0667 1 6 18 4 R.EGILKTAK.V

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581 431.7417 861.4688 861.4080 0.0609 0 13 3.4 2 K.AVEDEATK.G 4339 5156 436.2509 870.4872 870.4923 -0.0051 0 16 1.5 1 R.LQAAGNAVK.R 5175 436.7482 871.4818 871.4875 -0.0058 0 10 6.9 1 K.AVTQALNR.C 5173 5177 5684 445.7284 889.4423 889.4327 0.0096 0 3 35 8 K.ELIECAR.R 7149 474.2739 946.5332 946.4971 0.0361 0 1 45 2 K.ASSLIEEAK.K 7981 494.7850 987.5555 987.5600 -0.0045 0 48 0.0011 1 K.ALGDLISATK.A 8479 506.2436 1010.4727 1010.6236 -0.1509 1 9 6.5 4 K.KLEQLKPR.A 8926 516.3001 1030.5857 1030.6022 -0.0165 0 8 9.2 1 K.SIAAATSALVK.A 9870 533.2624 1064.5103 1064.5138 -0.0035 0 21 0.41 1 K.TSTPEDFIR.M 10253 542.7661 1083.5177 1083.6652 -0.1474 0 3 29 3 K.AVASAAAALVLK.A 10993 562.2380 1122.4615 1122.4975 -0.0360 0 3 25 2 K.CTQDLGNSTK.A 11393 570.7739 1139.5332 1139.5935 -0.0602 0 3 24 3 R.ALEATTEHIR.Q 11485 573.2935 1144.5725 1144.6088 -0.0363 0 35 0.016 1 K.EVANSTANLVK.T 12288 599.3149 1196.6152 1196.6401 -0.0249 0 23 0.24 1 K.ALSTDPAAPNLK.S 12630 611.7956 1221.5766 1221.5626 0.0140 0 42 0.0033 1 K.ALDGAFTEENR.A 12883 622.3303 1242.6460 1242.6568 -0.0108 0 60 4.1e-005 1 K.VLVQNAAGSQEK.L 13722 658.8152 1315.6158 1315.6732 -0.0574 0 11 3.9 4 R.QEDVIATANLSR.R 15172 562.9594 1685.8564 1685.9424 -0.0860 1 0 35 7 K.SIAAATSALVKAASAAQR.E

80. P31946|1433B_HUMAN Mass: 28179 Score: 118 Queries matched: 17 emPAI: 0.29 14-3-3 protein beta/alpha OS=Homo sapiens GN=YWHAB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6133 452.2562 902.4979 902.5073 -0.0094 0 48 0.00099 1 R.VISSIEQK.T 6127 6130 6132 947 995 454.2564 906.4982 906.5174 -0.0192 0 28 0.19 1 R.NLLSVAYK.N 6216 6217 6218 997 12041 591.7644 1181.5141 1181.5564 -0.0423 0 52 0.00031 1 R.YLSEVASGDNK.Q 12042 12981 626.7832 1251.5519 1251.6394 -0.0875 1 10 4.1 4 K.KEMQPTHPIR.L 12982 12984 12986 12987

81. P60660|MYL6_HUMAN Mass: 17090 Score: 117 Queries matched: 4 emPAI: 0.85 Myosin light polypeptide 6 OS=Homo sapiens GN=MYL6 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8107 498.2850 994.5554 994.5811 -0.0257 0 59 6.5e-005 1 R.HVLVTLGEK.M 8810 513.2462 1024.4779 1024.4978 -0.0199 0 40 0.0046 1 K.EAFQLFDR.T 14063 677.8524 1353.6903 1353.7252 -0.0349 0 65 1.6e-005 1 R.ALGQNPTNAEVLK.V 14062

82. P07197|NFM_HUMAN Mass: 102468 Score: 116 Queries matched: 22 emPAI: 0.04 Neurofilament medium polypeptide OS=Homo sapiens GN=NEFM PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2416 414.2117 826.4089 826.4225 -0.0136 0 5 14 5 R.FAGYIEK.V 2413 272 273 2422 2423 274 277 279 10962 561.2891 1120.5636 1120.5764 -0.0128 0 60 6e-005 1 R.EYQDLLNVK.M 10944 10949 10955 10956 10957 10960 10963 10964 1 13572 436.8747 1307.6022 1307.5113 0.0909 0 0 40 6 K.AGGEGGSEEEGSDK.G 1441 564.2679 1689.7818 1689.7668 0.0150 0 5 48 1 -.M SYTLDSLGNPSAYR.R

83. Q16352|AINX_HUMAN Mass: 55528 Score: 116 Queries matched: 18 emPAI: 0.07 Alpha-internexin OS=Homo sapiens GN=INA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10962 561.2891 1120.5636 1120.5764 -0.0128 0 60 6e-005 1 R.EYQDLLNVK.M 10944 10949 10955 10956 10957 10960 10963 10964 29 403.1614 1206.4624 1206.5251 -0.0627 1 3 1.5e+002 1 K.KEEEEEEASK.V 25 26 27 28 32 35

84. P60763|RAC3_HUMAN Mass: 21764 Score: 116 Queries matched: 7 emPAI: 0.63 Ras-related C3 botulinum toxin substrate 3 OS=Homo sapiens GN=RAC3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7232 475.7431 949.4716 949.4869 -0.0152 0 34 0.024 1 K.TVFDEAIR.A 7229 7230 7831 490.7671 979.5196 979.5525 -0.0329 0 44 0.002 1 R.AVLCPPPVK.K 12871 620.7897 1239.5648 1239.5918 -0.0270 0 64 1.8e-005 1 K.YLECSALTQR.G 12872 14927 506.5699 1516.6878 1516.8072 -0.1194 0 0 39 1 K.LAPITYPQGLAMAR.E

85. Q9H299|SH3L3_HUMAN Mass: 10488 Score: 115 Queries matched: 5 emPAI: 0.38 SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9574 528.7650 1055.5154 1055.5248 -0.0094 0 65 2e-005 1 R.VYSTSVTGSR.E 9569 9572 9573 12328 401.2250 1200.6531 1200.5921 0.0610 1 0 51 5 R.DEMRALAGNPK.A

86. P37837|TALDO_HUMAN Mass: 37688 Score: 114 Queries matched: 19 emPAI: 0.21 Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2392 413.7690 825.5234 825.5324 -0.0090 0 17 0.84 1 K.LVPVLSAK.A 2390 4341 432.2104 862.4062 862.4225 -0.0163 0 14 2.8 1 K.IYNYYK.K 4340 6837 466.7360 931.4573 931.4610 -0.0037 0 1 45 10 K.AAQASDLEK.I 10066 537.7651 1073.5156 1073.5353 -0.0197 0 55 0.00021 1 K.LGGSQEDQIK.N 10060 10063 10069 10073 10892 560.2756 1118.5366 1118.6084 -0.0718 1 9 7.9 6 K.FAADAVKLER.M 12738 617.2900 1232.5655 1232.5925 -0.0270 0 48 0.0007 1 K.SYEPLEDPGVK.S 12735 12736 12737 13520 650.3808 1298.7471 1298.6943 0.0529 1 0 39 8 K.IPGRVSTEVDAR.L 14105 681.3342 1360.6539 1360.6874 -0.0336 1 3 29 9 K.KSYEPLEDPGVK.S 14697 733.8204 1465.6262 1465.7413 -0.1151 1 9 4.6 3 R.VSTEVDARLSFDK.D 14867 500.5379 1498.5918 1498.6874 -0.0957 0 5 8.9 4 R.WLHNEDQMAVEK.L

87. Q8TF72|SHRM3_HUMAN Mass: 218125 Score: 113 Queries matched: 14 emPAI: 0.03 Protein Shroom3 OS=Homo sapiens GN=SHROOM3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1658 402.2155 802.4164 802.4548 -0.0384 0 33 0.034 2 R.ISESVLR.D 3658 422.2043 842.3941 842.4861 -0.0920 1 0 61 3 R.LTPEQKK.R 3789 425.7051 849.3956 849.4709 -0.0752 0 7 13 5 R.VLGATSFR.R 5213 437.2394 872.4643 872.5331 -0.0688 1 9 10 5 R.KEAVSLVK.G 6591 462.6991 923.3837 923.4573 -0.0737 1 4 21 7 R.SSSFAGGRR.L

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6827 466.7326 931.4507 931.4723 -0.0216 1 50 0.00063 1 R.SSPATADKR.Q 6828 6834 6836 6838 6839 6841 6921 469.7353 937.4560 937.4579 -0.0019 0 8 8 2 R.MFIGDLDK.V 12039 590.8603 1179.7060 1179.6499 0.0561 1 4 19 1 K.EAVSLVKGSYK.T

88. P26447|S10A4_HUMAN Mass: 11949 Score: 110 Queries matched: 12 emPAI: 2.14 Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2569 416.2453 830.4760 830.4861 -0.0101 1 34 0.028 1 K.LNKSELK.E 5687 445.7453 889.4760 889.4909 -0.0149 0 23 0.29 1 R.ELPSFLGK.R 5685 5686 6230 455.2139 908.4133 908.4239 -0.0106 0 47 0.0011 1 R.TDEAAFQK.L 6227 6228 6229 9820 533.2421 1064.4696 1064.4920 -0.0224 0 38 0.008 1 K.LMSNLDSNR.D 9860 533.2592 1064.5038 1064.5251 -0.0213 1 46 0.0014 1 K.RTDEAAFQK.L 9858 9868

89. P46940|IQGA1_HUMAN Mass: 189761 Score: 110 Queries matched: 25 emPAI: 0.08 Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens GN=IQGAP1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2434 414.2553 826.4960 826.5276 -0.0316 0 24 0.21 1 R.LIVDVIR.F 2522 415.7396 829.4647 829.4657 -0.0010 0 17 1.5 1 K.ELATLQR.Q 2517 5482 442.7559 883.4972 883.5855 -0.0883 1 3 25 3 K.IGLLVKNK.I 5487 6638 464.2450 926.4754 926.4419 0.0335 0 8 7.8 4 R.YLDELMK.L 6606 6608 6614 6616 6623 6627 6631 6632 6642 6648 6815 466.2501 930.4856 930.5022 -0.0165 0 33 0.033 1 K.TALQEEIK.S 8723 511.2535 1020.4925 1020.4910 0.0015 0 17 1 1 K.TCLDNLASK.G 8822 513.3053 1024.5959 1024.6029 -0.0070 0 63 2.5e-005 1 R.ALQSPALGLR.G 9947 536.7899 1071.5653 1071.5812 -0.0158 0 46 0.0018 1 K.LTELGTVDPK.N 10790 555.2403 1108.4660 1108.4706 -0.0047 0 0 40 10 R.LTAEEMDER.R 12409 603.7946 1205.5746 1205.6074 -0.0328 1 10 5.5 6 K.TCLDNLASKGK.V 12464 606.3495 1210.6844 1210.6532 0.0311 1 1 31 7 K.IPYGMRFIAK.V 12786 618.8170 1235.6194 1235.6510 -0.0315 0 44 0.0019 1 K.LQQTYAALNSK.A 786 440.2372 1317.6899 1317.6565 0.0334 0 1 1.5e+002 8 R.ALESGDVNTVWK.Q

90. P05107|ITB2_HUMAN Mass: 87976 Score: 109 Queries matched: 10 emPAI: 0.23 Integrin beta-2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2032 407.2499 812.4852 812.5007 -0.0155 0 28 0.075 1 K.LTEIIPK.S 2033 9516 524.2436 1046.4726 1046.4815 -0.0088 0 73 3e-006 1 R.TTEGCLNPR.R 10316 545.2753 1088.5361 1088.5462 -0.0101 0 43 0.0029 1 R.ALNEITESGR.I 10311 10312 10317 10319 11105 563.8011 1125.5876 1125.6142 -0.0266 0 35 0.015 1 K.LGAILTPNDGR.C 11456 572.2611 1142.5076 1142.5100 -0.0024 0 23 0.3 1 K.YISCAECLK.F

91. P15153|RAC2_HUMAN Mass: 21814 Score: 109 Queries matched: 7 emPAI: 0.62 Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens GN=RAC2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7232 475.7431 949.4716 949.4869 -0.0152 0 34 0.024 1 K.TVFDEAIR.A 7229 7230 9130 521.2734 1040.5323 1040.5437 -0.0114 0 30 0.044 1 R.AVLCPQPTR.Q 9119 12871 620.7897 1239.5648 1239.5918 -0.0270 0 64 1.8e-005 1 K.YLECSALTQR.G 12872

92. P62942|FKB1A_HUMAN Mass: 12000 Score: 105 Queries matched: 2 emPAI: 0.33 Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens GN=FKBP1A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13712 657.8112 1313.6079 1313.6576 -0.0497 0 66 1.1e-005 1 M.GVQVETISPGDGR.T 13713

93. P37802|TAGL2_HUMAN Mass: 22548 Score: 104 Queries matched: 8 emPAI: 1.19 Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2078 410.7128 819.4109 819.4239 -0.0129 0 36 0.016 1 R.GPAYGLSR.E 2076 2077 7832 491.2502 980.4859 980.5152 -0.0293 0 21 0.43 1 K.DVGRPQPGR.E 10151 539.7534 1077.4923 1077.5243 -0.0320 0 34 0.023 1 R.ENFQNWLK.D 12539 609.8113 1217.6081 1217.6187 -0.0105 0 34 0.022 1 K.NVIGLQM GTNR.G 12699 616.3288 1230.6430 1230.6754 -0.0324 0 40 0.0053 1 R.TLMNLGGLAVAR.D 13306 640.2838 1278.5530 1278.5840 -0.0311 0 49 0.00052 1 R.NFSDNQLQEGK.N

94. P01040|CYTA_HUMAN Mass: 11000 Score: 104 Queries matched: 31 emPAI: 1.53 Cystatin-A OS=Homo sapiens GN=CSTA PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3791 425.7204 849.4262 849.4596 -0.0334 0 38 0.009 1 K.LEAVQYK.T 3788 487 3792 7553 485.7725 969.5304 969.5495 -0.0190 0 26 0.11 1 K.VKPQLEEK.T 7548 7551 7552 1197 7554 7555 7556 7557 7558 9077 519.7213 1037.4281 1037.4666 -0.0384 1 36 0.012 1 K.NKDDELTGF.- 9078 9079 9081 9082 9083 9084 9085 9086 9087 9088 14076 678.8353 1355.6561 1355.7085 -0.0524 0 53 0.00025 1 K.TQVVAGTNYYIK.V

95. P35241|RADI_HUMAN Mass: 68635 Score: 103 Queries matched: 10 emPAI: 0.23 Radixin OS=Homo sapiens GN=RDX PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2566 416.2447 830.4748 830.4359 0.0390 1 14 3.2 9 R.QGNTKQR.I 325 419.2006 836.3866 836.4028 -0.0162 0 13 9.2 1 R.NISFNDK.K 5290 438.2340 874.4535 874.4548 -0.0014 0 12 4.6 1 K.ENPLQFK.F 5297 5724 447.7655 893.5164 893.5375 -0.0211 0 10 5.7 2 R.LFFLQVK.E 7516 483.2473 964.4800 964.4978 -0.0178 1 27 0.11 1 R.NISFNDKK.F 7794 488.7752 975.5358 975.5389 -0.0031 0 49 0.00082 1 K.QLFDQVVK.T 12043 591.7836 1181.5527 1181.5869 -0.0343 0 37 0.01 1 K.APDFVFYAPR.L 12698 616.2936 1230.5727 1230.6204 -0.0477 1 65 1.7e-005 1 K.AQKELEEQTR.K 13295 639.3147 1276.6149 1276.6445 -0.0296 1 4 19 2 K.SAIAKQAADQMK.N

96. P16150|LEUK_HUMAN Mass: 40297 Score: 102 Queries matched: 3 emPAI: 0.09

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Leukosialin OS=Homo sapiens GN=SPN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2059 408.7486 815.4827 815.4865 -0.0038 0 61 6.1e-005 1 R.TGALVLSR.G 2055 2057

97. Q9NZT1|CALL5_HUMAN Mass: 15883 Score: 102 Queries matched: 14 emPAI: 0.93 Calmodulin-like protein 5 OS=Homo sapiens GN=CALML5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6728 465.7456 929.4766 929.4930 -0.0164 0 35 0.019 1 K.NLSEAQLR.K 6725 6727 6729 6730 6731 6732 6733 6735 6736 8831 514.2366 1026.4586 1026.4770 -0.0184 0 25 0.15 1 R.VNYEEFAR.M 9622 529.7813 1057.5480 1057.5880 -0.0399 1 18 1 1 K.NLSEAQLRK.L 9604 12547 609.8230 1217.6315 1217.6404 -0.0089 0 73 2.7e-006 1 R.AGLEDLQVAFR.A

98. P31944|CASPE_HUMAN Mass: 27947 Score: 100 Queries matched: 10 emPAI: 0.66 Caspase-14 OS=Homo sapiens GN=CASP14 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7498 482.7343 963.4540 963.4774 -0.0234 0 34 0.023 1 K.FQQAIDSR.E 7497 7499 7500 7501 8737 511.7651 1021.5157 1021.5379 -0.0222 0 12 3.3 2 K.VYIIQACR.G 11660 579.7891 1157.5636 1157.6040 -0.0404 0 30 0.054 1 K.TNPEIQSTLR.K 11662 13393 429.5722 1285.6947 1285.6990 -0.0043 1 30 0.051 1 R.KTNPEIQSTLR.K 15038 782.3555 1562.6964 1562.7100 -0.0136 0 67 9.1e-006 1 R.DPTAEQFQEELEK.F

99. P00918|CAH2_HUMAN Mass: 29285 Score: 98 Queries matched: 10 emPAI: 0.84 Carbonic anhydrase 2 OS=Homo sapiens GN=CA2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6904 468.2151 934.4157 934.4509 -0.0351 0 34 0.023 1 K.GGPLDGTYR.L 6905 6906 7890 492.7896 983.5647 983.5764 -0.0117 0 23 0.29 1 K.VGSAKPGLQK.V 1232 494.2753 986.5361 986.5648 -0.0287 0 31 0.15 1 K.VVDVLDSIK.T 1233 11829 585.2499 1168.4853 1168.5149 -0.0296 0 42 0.0026 1 K.SADFTNFDPR.G 11830 13690 437.8796 1310.6169 1310.6467 -0.0298 0 20 0.46 1 R.QSPVDIDTHTAK.Y 13716 658.3337 1314.6528 1314.7031 -0.0503 0 39 0.0064 1 K.EPISVSSEQVLK.F

100. P31947|1433S_HUMAN Mass: 27871 Score: 96 Queries matched: 15 emPAI: 0.29 14-3-3 protein sigma OS=Homo sapiens GN=SFN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4285 429.7270 857.4395 857.5334 -0.0939 1 12 5.1 2 R.ASLIQKAK.L 4282 4300 6133 452.2562 902.4979 902.5073 -0.0094 0 48 0.00099 1 R.VLSSIEQK.S 6127 6130 6132 947 995 454.2564 906.4982 906.5174 -0.0192 0 28 0.19 1 R.NLLSVAYK.N 6216 6217 6218 997 10956 561.2861 1120.5575 1120.4569 0.1007 0 8 8 4 R.YEDMAAFMK.G 15004 516.2330 1545.6773 1545.6907 -0.0134 1 44 0.0016 1 K.SNEEGSEEKGPEVR.E

101. P20702|ITAX_HUMAN Mass: 128946 Score: 96 Queries matched: 13 emPAI: 0.12 Integrin alpha-X OS=Homo sapiens GN=ITGAX PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6537 459.7493 917.4839 917.4930 -0.0091 0 47 0.0012 1 R.IAGSQLSSR.L 6536 7517 483.7344 965.4543 965.4501 0.0042 0 13 2.2 3 K.ESHVAMHR.Y 7559 486.2262 970.4377 970.6063 -0.1685 0 3 25 6 K.ILIVITDGK.K 8005 495.7749 989.5353 989.5393 -0.0041 0 24 0.28 1 R.AQTTTVLEK.Y 8001 8720 510.7856 1019.5567 1019.5764 -0.0197 0 37 0.011 1 K.AVIFTQVSR.Q 10837 558.2851 1114.5557 1114.5982 -0.0425 1 18 0.94 6 K.DIQNQLKEK.I 10833 10834 11833 585.3014 1168.5882 1168.6023 -0.0140 0 48 0.00075 1 R.GGQVSVCPLPR.G 11834 11935 589.3306 1176.6466 1176.6152 0.0314 1 2 37 2 R.LFHASYGARR.D

102. Q9BQE3|TBA1C_HUMAN Mass: 50548 Score: 94 Queries matched: 4 emPAI: 0.15 Tubulin alpha-1C chain OS=Homo sapiens GN=TUBA1C PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6236 455.2489 908.4833 908.4967 -0.0134 1 45 0.0016 1 R.LSVDYGKK.S 6238 8546 508.2748 1014.5351 1014.5709 -0.0358 0 58 9.9e-005 1 K.DVNAAIATIK.T 8564

Proteins matching the same set of peptides: Q71U36|TBA1A_HUMAN Mass: 50788 Score: 94 Queries matched: 4 Tubulin alpha-1A chain OS=Homo sapiens GN=TUBA1A PE=1 SV=1 Q13748|TBA3C_HUMAN Mass: 50612 Score: 94 Queries matched: 4 Tubulin alpha-3C/D chain OS=Homo sapiens GN=TUBA3C PE=1 SV=3 P68363|TBA1B_HUMAN Mass: 50804 Score: 94 Queries matched: 4 Tubulin alpha-1B chain OS=Homo sapiens GN=TUBA1B PE=1 SV=1

103. P07339|CATD_HUMAN Mass: 45037 Score: 93 Queries matched: 26 emPAI: 0.17 Cathepsin D OS=Homo sapiens GN=CTSD PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2080 410.7197 819.4249 819.4239 0.0010 0 49 0.00089 1 R.VGFAEAAR.L 2075 2079 2081 9327 523.2904 1044.5662 1044.5968 -0.0306 0 0 56 8 K.QPGITFIAAK.F 9859 533.2590 1064.5034 1064.5390 -0.0355 0 38 0.0081 1 K.LSPEDYTLK.V 9872 9874 1376 12468 606.3507 1210.6868 1210.7186 -0.0318 1 5 13 1 R.IPLHKFTSIR.R 12462 12463 12465 12469 12470 12472 12474 12477

104. P11021|GRP78_HUMAN Mass: 72402 Score: 92 Queries matched: 8 emPAI: 0.05 78 kDa glucose-regulated protein OS=Homo sapiens GN=HSPA5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1157 476.2400 475.2327 475.2391 -0.0064 0 3 52 1 K.GTGNK.N 7933 493.7549 985.4953 985.5080 -0.0127 0 22 0.35 1 R.LTPEEIER.M 8982 517.2548 1032.4951 1032.5451 -0.0500 1 5 19 10 K.LGGKLSSEDK.E 8985 10077 537.7723 1073.5300 1073.5465 -0.0165 0 21 0.43 1 K.ITITNDQNR.L 10800 555.2667 1108.5188 1108.5764 -0.0576 1 4 19 5 K.ETAEAYLGKK.V 12671 614.7982 1227.5819 1227.6207 -0.0388 0 76 1.4e-006 1 R.VEIIANDQGNR.I 12673

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105. P04792|HSPB1_HUMAN Mass: 22826 Score: 89 Queries matched: 4 emPAI: 0.59 Heat shock protein beta-1 OS=Homo sapiens GN=HSPB1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1046 459.2507 916.4868 916.4866 0.0003 0 56 0.00056 1 K.DGVVEITGK.H 7005 471.2391 940.4637 940.4978 -0.0341 0 48 0.00078 1 R.AQLGGPEAAK.S 7015 10112 538.2750 1074.5355 1074.5669 -0.0315 0 37 0.01 1 R.QLSSGVSEIR.H

106. P11215|ITAM_HUMAN Mass: 128410 Score: 89 Queries matched: 18 emPAI: 0.12 Integrin alpha-M OS=Homo sapiens GN=ITGAM PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5437 442.2393 882.4640 882.4746 -0.0106 0 20 0.48 1 R.VCLHVQK.S 1215 489.2746 976.5346 976.4800 0.0546 0 13 14 1 K.AIMEFNPR.E 7879 492.7434 983.4722 983.5512 -0.0790 1 13 2.5 2 R.THTATGIRK.V 7870 7872 7873 7874 7876 7877 7878 7880 7882 7883 9109 520.3137 1038.6128 1038.6186 -0.0057 0 36 0.013 1 R.VQSLVLGAPR.Y 10291 543.8199 1085.6252 1085.6332 -0.0080 0 33 0.027 1 K.ILVVITDGEK.F 10832 558.2565 1114.4984 1114.5155 -0.0172 0 36 0.013 1 K.EFQNNPNPR.S 11833 585.3014 1168.5882 1168.6023 -0.0140 0 48 0.00075 1 R.GGQVSVCPLPR.G 11834

107. O75083|WDR1_HUMAN Mass: 66836 Score: 88 Queries matched: 14 emPAI: 0.18 WD repeat-containing protein 1 OS=Homo sapiens GN=WDR1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1600 400.7256 799.4366 799.4552 -0.0186 0 40 0.0059 1 R.IAVVGEGR.E 1602 1603 827 444.2553 886.4960 886.5124 -0.0163 0 25 0.93 1 K.VINSVDIK.Q 6003 450.2567 898.4989 898.4582 0.0407 0 5 17 1 R.YTSLMLR.D 6010 7244 476.7286 951.4426 951.4662 -0.0236 0 41 0.0037 1 R.DYSGQGVVK.L 7245 7261 478.7490 955.4835 955.5563 -0.0728 1 10 5.8 3 K.RIAVVGEGR.E 7262 7263 7264 10268 543.2763 1084.5381 1084.5699 -0.0318 0 6 15 2 K.SIQCLTVHK.N 10582 551.7617 1101.5089 1101.5131 -0.0042 0 38 0.0092 1 K.YEYQPFAGK.I

108. P62937|PPIA_HUMAN Mass: 18229 Score: 83 Queries matched: 5 emPAI: 1.62 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens GN=PPIA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3757 424.6937 847.3729 847.4076 -0.0347 0 30 0.063 1 K.TEWLDGK.H 9565 528.2568 1054.4990 1054.5335 -0.0345 0 36 0.014 1 R.VSFELFADK.V 11598 577.7742 1153.5338 1153.5655 -0.0317 0 32 0.029 1 K.FEDENFILK.H 12907 624.2986 1246.5826 1246.6227 -0.0401 1 57 0.0001 1 K.KITIADCGQLE.- 15001 513.2337 1536.6792 1536.7276 -0.0484 1 26 0.093 1 K.VKEGMNIVEAMER.F

109. P15311|EZRI_HUMAN Mass: 69484 Score: 83 Queries matched: 14 emPAI: 0.23 Ezrin OS=Homo sapiens GN=EZR PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2566 416.2447 830.4748 830.4359 0.0390 1 14 3.2 9 R.QGNTKQR.I 325 419.2006 836.3866 836.4028 -0.0162 0 13 9.2 1 R.NISFNDK.K 5290 438.2340 874.4535 874.4548 -0.0014 0 12 4.6 1 K.ENPLQFK.F 5297 5724 447.7655 893.5164 893.5375 -0.0211 0 10 5.7 2 K.LFFLQVK.E 5907 449.7094 897.4042 897.4192 -0.0149 0 18 0.72 1 K.SGYLSSER.L 6460 457.7568 913.4990 913.5232 -0.0243 0 46 0.0013 1 K.IALLEEAR.R 6497 458.7561 915.4976 915.5138 -0.0161 1 22 0.38 2 K.KVSAQEVR.K 7516 483.2473 964.4800 964.4978 -0.0178 1 27 0.11 1 R.NISFNDKK.F 7794 488.7752 975.5358 975.5389 -0.0031 0 49 0.00082 1 K.QLFDQVVK.T 7941 494.2535 986.4925 986.5032 -0.0107 0 11 4.6 3 R.ALQLEEER.K 7940 9907 535.8049 1069.5952 1069.6243 -0.0291 1 4 20 5 K.IALLEEARR.R 12043 591.7836 1181.5527 1181.5869 -0.0343 0 37 0.01 1 K.APDFVFYAPR.L

110. P13639|EF2_HUMAN Mass: 96246 Score: 83 Queries matched: 15 emPAI: 0.25 Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2651 419.2061 836.3976 836.4248 -0.0272 0 0 52 4 R.TILMMGR.Y 6246 456.2119 910.4093 910.4185 -0.0092 0 10 4.1 1 R.YFDPANGK.F 6560 461.7337 921.4529 921.4556 -0.0027 0 31 0.038 1 K.SDPVVSYR.E 6555 7543 485.2671 968.5197 968.5403 -0.0206 0 33 0.026 1 R.GGGQIIPTAR.R 7544 7545 8491 507.2536 1012.4927 1012.4938 -0.0011 0 26 0.13 1 K.GEGQLGPAER.A 1289 8832 514.2654 1026.5163 1026.6073 -0.0910 1 12 3.5 4 K.DKEGKPLLK.A 10456 546.2881 1090.5616 1090.5771 -0.0156 0 48 0.00096 1 M.VNFTVDQIR.A 10488 547.2526 1092.4906 1092.5274 -0.0368 0 11 4 1 R.IMGPNYTPGK.K 10614 553.2363 1104.4581 1104.6035 -0.1454 0 5 16 4 R.IKPVLMMNK.M 10765 554.3191 1106.6237 1106.6336 -0.0098 0 42 0.0037 1 R.VFSGLVSTGLK.V 10997 562.2683 1122.5221 1122.5591 -0.0370 0 29 0.061 1 K.STLTDSLVCK.A

111. O15511|ARPC5_HUMAN Mass: 16367 Score: 81 Queries matched: 5 emPAI: 0.24 Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens GN=ARPC5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7412 479.7400 957.4655 957.5607 -0.0952 1 8 8.5 5 K.DRAGSIVLK.V 9907 535.8049 1069.5952 1069.6244 -0.0292 0 61 4.1e-005 1 K.ALAAGGVGSIVR.V 9904 9905 9906

112. P06753|TPM3_HUMAN Mass: 32856 Score: 80 Queries matched: 37 emPAI: 0.39 Tropomyosin alpha-3 chain OS=Homo sapiens GN=TPM3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5717 447.7154 893.4162 893.4606 -0.0444 1 6 15 1 K.YEEVARK.L 5719 447.7300 893.4454 893.4606 -0.0153 1 20 0.6 1 R.KYEEVAR.K 7040 471.7681 941.5216 941.5658 -0.0441 1 5 15 7 K.VIENRALK.D 12882 622.3294 1242.6442 1242.6456 -0.0013 0 25 0.13 1 R.IQLVEEELDR.A 13722 658.8152 1315.6158 1315.6368 -0.0210 0 63 2.3e-005 1 K.AADAEAEVASLNR.R 14725 738.3655 1474.7164 1474.7701 -0.0537 1 24 0.17 2 K.MELQEIQLKEAK.H 14722 14726 14727 14728 14729 14730 14731 14

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14762 492.8845 1475.6318 1475.6739 -0.0422 1 36 0.01 1 K.LEEAEKAADESER.G

113. P27482|CALL3_HUMAN Mass: 16937 Score: 79 Queries matched: 2 emPAI: 0.51 Calmodulin-like protein 3 OS=Homo sapiens GN=CALML3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1677 403.2136 804.4127 804.4164 -0.0037 0 36 0.019 1 R.ELGTVMR.S 13715 657.8321 1313.6497 1313.6575 -0.0078 0 71 3.4e-006 1 R.SLGQNPTEAELR.D

114. P08758|ANXA5_HUMAN Mass: 35971 Score: 79 Queries matched: 7 emPAI: 0.49 Annexin A5 OS=Homo sapiens GN=ANXA5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5716 447.2342 892.4538 892.4654 -0.0116 0 44 0.0025 1 R.QEISAAFK.T 5713 6129 452.2515 902.4885 902.4821 0.0064 1 3 32 1 R.ADAETLRK.A 8285 501.2996 1000.5847 1000.5917 -0.0070 0 30 0.055 1 K.VLTEIIASR.T 8521 507.7475 1013.4804 1013.5069 -0.0266 0 25 0.19 1 R.LYDAYELK.H 8522 11601 578.2835 1154.5525 1154.5680 -0.0155 0 57 8.5e-005 1 K.GAGTDDHTLIR.V

115. Q02413|DSG1_HUMAN Mass: 114670 Score: 79 Queries matched: 4 emPAI: 0.07 Desmoglein-1 OS=Homo sapiens GN=DSG1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2056 408.7443 815.4741 815.4752 -0.0011 0 40 0.0079 1 K.LADISLGK.E 2058 2060 10892 560.2756 1118.5366 1118.5568 -0.0202 0 69 7e-006 1 R.ESSNVVVTER.V

116. P02787|TRFE_HUMAN Mass: 79280 Score: 78 Queries matched: 29 emPAI: 0.26 Serotransferrin OS=Homo sapiens GN=TF PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2404 414.1987 826.3828 826.3973 -0.0145 0 53 0.00026 1 K.NPDPWAK.N 2409 5237 437.7244 873.4343 873.4345 -0.0001 0 13 3.5 1 K.DSAHGFLK.V 7503 482.7662 963.5179 963.5250 -0.0071 0 31 0.047 1 R.APNHAVVTR.K 7817 489.7376 977.4605 977.4818 -0.0213 0 29 0.081 1 K.DGAGDVAFVK.H 7816 1242 499.2349 996.4553 996.4698 -0.0146 0 28 0.2 1 K.ASYLDCIR.A 1248 8157 500.7451 999.4756 999.4913 -0.0156 0 25 0.19 1 K.YLGEEYVK.A 8156 11068 563.2567 1124.4989 1124.6124 -0.1135 1 13 2.3 2 K.EACVHKILR.Q 11061 11062 11063 11065 11066 11069 11071 11072 13885 670.2889 1338.5633 1338.6350 -0.0717 1 4 17 5 K.KDSGFQMNQLR.G

117. P20930|FILA_HUMAN Mass: 435036 Score: 78 Queries matched: 29 emPAI: 0.03 Filaggrin OS=Homo sapiens GN=FLG PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7593 486.7778 971.5411 971.5512 -0.0101 1 11 5.3 2 R.KRPSSLER.R 8158 500.7492 999.4839 999.5573 -0.0734 1 11 4.6 2 K.RPSSLERR.N 10762 554.3141 1106.6137 1106.5065 0.1072 1 0 50 1 R.GQSGESSGRSR.S 10987 561.8143 1121.6141 1121.6193 -0.0052 1 33 0.031 1 R.KENLPISGHK.H 11656 579.7856 1157.5567 1157.6305 -0.0738 1 10 5.2 7 R.QKGQSGLVWR.H 11634 11636 11640 11642 11644 11645 11646 1164 12321 601.2910 1200.5674 1200.5775 -0.0101 0 63 2.7e-005 1 K.LAQAYYESTR.K 13639 655.3706 1308.7267 1308.6535 0.0732 0 4 18 1 R.HSLVGQGQSSGPR.T 13596 13603 13609 13626 13628 13810 443.8949 1328.6629 1328.6724 -0.0095 1 26 0.12 1 K.LAQAYYESTRK.E 13885 670.2889 1338.5633 1338.6025 -0.0391 1 5 14 3 R.HHEASSRADSSR.H 14865 749.7738 1497.5331 1497.6669 -0.1338 1 3 7.1 5 R.SDASHGHSGSRSASR.Q 14863 14864 14866 15033 518.2419 1551.7038 1551.6954 0.0084 1 5 12 1 K.GYSPTHREEEYGK.N

118. O75223|GGCT_HUMAN Mass: 21222 Score: 78 Queries matched: 6 emPAI: 0.65 Gamma-glutamylcyclotransferase OS=Homo sapiens GN=GGCT PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10726 554.2501 1106.4856 1106.5244 -0.0388 0 40 0.0058 1 K.AIEPNDYTGK.V 10731 10732 10742 13728 660.3234 1318.6322 1318.6405 -0.0083 0 21 0.44 1 K.ENGLPLEYQEK.L 14549 716.8336 1431.6526 1431.6841 -0.0315 0 67 7.9e-006 1 K.SNLNSLDEQEGVK.S

119. P04080|CYTB_HUMAN Mass: 11190 Score: 77 Queries matched: 6 emPAI: 0.36 Cystatin-B OS=Homo sapiens GN=CSTB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6589 462.6935 923.3724 923.4025 -0.0301 0 16 1.1 1 K.HDELTYF.- 6590 10996 562.2579 1122.5012 1122.5346 -0.0333 1 11 3.6 1 K.AKHDELTYF.- 10995 13752 663.8401 1325.6655 1325.6980 -0.0324 0 55 0.00014 1 K.SQVVAGTNYFIK.V 13751

120. P62805|H4_HUMAN Mass: 11360 Score: 77 Queries matched: 5 emPAI: 1.47 Histone H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7997 495.2855 988.5564 988.5706 -0.0142 0 21 0.47 1 K.VFLENVIR.D 11314 567.7591 1133.5036 1133.5353 -0.0317 0 44 0.0023 1 R.DAVTYTEHAK.R 12031 590.7914 1179.5682 1179.6135 -0.0453 0 56 0.00013 1 R.ISGLIYEETR.G 13748 442.5763 1324.7072 1324.7463 -0.0391 0 32 0.026 1 R.DNIQGITKPAIR.R 13749

121. P09960|LKHA4_HUMAN Mass: 69868 Score: 76 Queries matched: 5 emPAI: 0.11 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4336 431.7233 861.4320 861.4596 -0.0276 0 10 7.7 1 R.TLVWSEK.E 7927 493.2736 984.5327 984.5604 -0.0277 0 15 1.8 1 K.VVINGQEVK.Y 12419 604.3194 1206.6242 1206.6496 -0.0254 0 49 0.0006 1 K.LTYTAEVSVPK.E 13710 657.7683 1313.5220 1313.5372 -0.0152 0 52 0.00021 1 R.DGETPDPEDPSR.K 13808 664.8374 1327.6602 1327.6806 -0.0204 0 12 2.7 1 R.AILPCQDTPSVK.L

122. P58546|MTPN_HUMAN Mass: 13058 Score: 74 Queries matched: 1 emPAI: 0.30 Myotrophin OS=Homo sapiens GN=MTPN PE=1 SV=2

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15189 874.4013 1746.7880 1746.8424 -0.0544 0 74 1.3e-006 1 K.GPDGLTAFEATDNQAIK.A

123. Q16555|DPYL2_HUMAN Mass: 62711 Score: 74 Queries matched: 4 emPAI: 0.06 Dihydropyrimidinase-related protein 2 OS=Homo sapiens GN=DPYSL2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2032 407.2499 812.4852 812.4140 0.0711 0 6 12 3 K.TIEAHSR.M 8910 516.2655 1030.5165 1030.5407 -0.0242 0 74 2.4e-006 1 K.SSAEVIAQAR.K 8911 12984 626.7863 1251.5579 1251.7048 -0.1468 1 3 22 10 R.TTQRIVAPPGGR.A

124. P47929|LEG7_HUMAN Mass: 15123 Score: 73 Queries matched: 4 emPAI: 0.26 Galectin-7 OS=Homo sapiens GN=LGALS7 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4276 429.2333 856.4520 856.4556 -0.0035 0 15 2.2 1 R.GPGVPFQR.G 6241 455.7512 909.4879 909.5032 -0.0153 0 28 0.076 1 R.GLVPPNASR.F 6240 12797 619.8130 1237.6114 1237.6190 -0.0076 0 73 2.1e-006 1 R.LDTSEVVFNSK.E

125. P19971|TYPH_HUMAN Mass: 50323 Score: 72 Queries matched: 5 emPAI: 0.33 Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1658 402.2155 802.4164 802.4185 -0.0020 0 35 0.022 1 R.LSEADIR.G 9515 524.2434 1046.4722 1046.4815 -0.0093 0 37 0.011 1 R.ALCSGSPAER.R 10252 542.7636 1083.5127 1083.5309 -0.0182 0 33 0.025 1 R.DGPALSGPQSR.A 12523 608.3099 1214.6053 1214.6255 -0.0202 0 56 0.00015 1 R.VAAALDDGSALGR.F 13710 657.7683 1313.5220 1313.6762 -0.1542 0 4 15 7 R.MLAAQGVDPGLAR.A

126. P14923|PLAK_HUMAN Mass: 82434 Score: 72 Queries matched: 9 emPAI: 0.25 Junction plakoglobin OS=Homo sapiens GN=JUP PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2028 406.7799 811.5452 811.5531 -0.0079 0 33 0.019 1 R.LVQLLVK.A 3744 424.2274 846.4401 846.4447 -0.0045 0 47 0.0015 1 R.NLSDVATK.Q 5311 438.7503 875.4860 875.4865 -0.0005 0 13 3.3 1 K.LLWTTSR.V 8132 499.7924 997.5702 997.5808 -0.0106 0 28 0.088 1 R.LAEPSQLLK.S 10082 537.7983 1073.5821 1073.5903 -0.0082 0 39 0.0076 1 K.AAMIVNQLSK.K 10296 544.3201 1086.6257 1086.6437 -0.0180 0 40 0.0058 1 R.LNYGIPAIVK.L 12323 401.2202 1200.6388 1200.6649 -0.0261 1 1 40 7 K.MAVRLADGLQK.M 12784 412.8614 1235.5623 1235.5782 -0.0159 1 21 0.34 1 R.ISEDKNPDYR.K 12785

127. Q86UX7|URP2_HUMAN Mass: 76475 Score: 72 Queries matched: 6 emPAI: 0.27 Fermitin family homolog 3 OS=Homo sapiens GN=FERMT3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5152 436.2454 870.4762 870.4923 -0.0161 0 32 0.04 1 K.IVEQINR.K 5332 439.7301 877.4457 877.4657 -0.0200 0 47 0.0011 1 K.YGILADAR.L 6090 451.2330 900.4515 900.4817 -0.0303 0 25 0.2 1 K.AGDALWLR.F 8361 502.7449 1003.4753 1003.4862 -0.0109 0 20 0.55 1 K.ETTLSYYK.S 8848 514.7963 1027.5781 1027.5914 -0.0133 0 31 0.043 1 R.IDLAVGDVVK.T 10969 561.2943 1120.5740 1120.5876 -0.0136 0 49 0.00075 1 R.LTQLYEQAR.W

128. O43150|ASAP2_HUMAN Mass: 112835 Score: 71 Queries matched: 32 emPAI: 0.03 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens GN=ASAP2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7523 484.2310 966.4475 966.5359 -0.0884 1 4 20 6 K.LQPSPNRR.E 7597 487.2511 972.4876 972.5240 -0.0364 0 45 0.0019 2 K.EIISEVQR.M 7595 7596 7598 7599 7600 7601 7602 7603 7604 7605 7 8169 500.7876 999.5606 999.6077 -0.0471 1 1 53 1 K.SQATKLKPK.R 9047 518.3099 1034.6053 1034.5032 0.1021 0 1 45 4 K.EEALNNAFK.G 9054

129. Q01518|CAP1_HUMAN Mass: 52222 Score: 71 Queries matched: 9 emPAI: 0.15 Adenylyl cyclase-associated protein 1 OS=Homo sapiens GN=CAP1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2175 412.7421 823.4697 823.3712 0.0985 0 1 38 2 R.GYADSPSK.A 316 416.2809 830.5472 830.3593 0.1880 0 5 1.1e+002 1 K.HVSDDMK.T 5161 436.2562 870.4979 870.5175 -0.0195 0 15 1.9 1 K.VPTISINK.T 5154 5452 442.7424 883.4702 883.4803 -0.0102 0 15 1.4 1 K.QVAYIYK.C 10254 542.7911 1083.5677 1083.5812 -0.0135 0 32 0.032 1 K.EPAVLELEGK.K 12515 607.2906 1212.5666 1212.5557 0.0109 1 7 8.7 3 K.HVSDDMKTHK.N 12780 618.2860 1234.5575 1234.5863 -0.0288 0 67 9.7e-006 1 K.NSLDCEIVSAK.S 12847 619.8613 1237.7080 1237.5431 0.1649 0 1 33 1 -.MADMQNLVER.L

130. Q8TER0|SNED1_HUMAN Mass: 158206 Score: 70 Queries matched: 50 emPAI: 0.05 Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens GN=SNED1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1865 405.2145 808.4145 808.4443 -0.0298 0 36 0.014 2 K.LASYTVR.D 1859 1860 1861 1863 1864 1866 1867 1868 1869 1870 18 3669 422.2403 842.4660 842.3923 0.0737 0 4 23 5 R.AGDVYYR.E 6543 460.2313 918.4480 918.4043 0.0437 0 32 0.04 1 R.DQATDVDR.S 6544 8677 510.2396 1018.4646 1018.4753 -0.0108 0 9 7.5 7 R.EATDPAMLR.R 8676 8678 8679

131. P60903|S10AA_HUMAN Mass: 11310 Score: 70 Queries matched: 2 emPAI: 0.35 Protein S100-A10 OS=Homo sapiens GN=S100A10 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10578 550.2689 1098.5233 1098.5710 -0.0477 1 54 0.00019 1 K.FAGDKGYLTK.E 10579

132. P68871|HBB_HUMAN Mass: 16102 Score: 69 Queries matched: 2 emPAI: 0.54

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Hemoglobin subunit beta OS=Homo sapiens GN=HBB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7246 476.7414 951.4682 951.5025 -0.0343 0 36 0.013 1 M.VHLTPEEK.S 13714 657.8217 1313.6289 1313.6575 -0.0287 0 62 3e-005 1 K.VNVDEVGGEALGR.L

133. P06702|S10A9_HUMAN Mass: 13291 Score: 68 Queries matched: 10 emPAI: 1.17 Protein S100-A9 OS=Homo sapiens GN=S100A9 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5322 439.2341 876.4535 876.4705 -0.0170 0 20 0.57 1 K.DLQNFLK.K 7562 486.2452 970.4759 970.4872 -0.0113 0 29 0.073 1 R.LTWASHEK.M 7559 8417 503.2713 1004.5280 1004.5655 -0.0375 1 40 0.0057 1 K.DLQNFLKK.E 8419 503.2879 1004.5613 1004.5655 -0.0041 1 37 0.011 1 R.KDLQNFLK.K 8418 13499 650.2980 1298.5815 1298.5781 0.0034 1 2 26 5 -.MTCKMSQLER.N 14658 485.8971 1454.6694 1454.7154 -0.0460 0 31 0.037 1 K.LGHPDTLNQGEFK.E 14659 15146 549.6035 1645.7886 1645.7844 0.0043 0 2 26 7 K.QLSFEEFIMLMAR.L

134. P53396|ACLY_HUMAN Mass: 121674 Score: 67 Queries matched: 14 emPAI: 0.06 ATP-citrate synthase OS=Homo sapiens GN=ACLY PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2166 412.7406 823.4666 823.3316 0.1350 0 2 28 2 K.NM ADAMR.K 5268 437.7490 873.4834 873.4709 0.0126 0 10 7.2 4 K.EAGVFVPR.S 5259 5271 5275 5276 5277 5278 5283 5284 5285 6118 451.7453 901.4760 901.4869 -0.0109 0 46 0.0017 1 R.LGQEATVGK.A 6211 454.2116 906.4086 906.4447 -0.0361 0 22 0.35 1 R.YQDTPGVK.M 6549 460.7407 919.4668 919.4763 -0.0095 0 50 0.00052 1 R.FGGALDAAAK.M

135. Q96C19|EFHD2_HUMAN Mass: 26794 Score: 67 Queries matched: 17 emPAI: 0.30 EF-hand domain-containing protein D2 OS=Homo sapiens GN=EFHD2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7623 487.2654 972.5162 972.5352 -0.0191 0 26 0.15 1 K.VQAINVSSR.F 13136 631.8087 1261.6029 1261.6402 -0.0373 0 67 9.6e-006 1 R.LSEIDVSSEGVK.G 13104 13107 13109 13111 13112 13114 13115 13

136. P78417|GSTO1_HUMAN Mass: 27833 Score: 66 Queries matched: 6 emPAI: 0.47 Glutathione S-transferase omega-1 OS=Homo sapiens GN=GSTO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6602 463.7054 925.3963 925.4116 -0.0153 0 36 0.011 1 R.FCPFAER.T 10313 545.2650 1088.5155 1088.5390 -0.0235 0 25 0.19 1 K.LLPDDPYEK.A 10315 12505 404.8549 1211.5429 1211.5605 -0.0176 0 22 0.31 1 K.LNECVDHTPK.L 13736 660.8316 1319.6487 1319.6834 -0.0346 0 42 0.0032 1 K.GSAPPGPVPEGSIR.I 13734

137. P63244|GBLP_HUMAN Mass: 35511 Score: 65 Queries matched: 2 emPAI: 0.11 Guanine nucleotide-binding protein subunit beta-2-like 1 OS=Homo sapiens GN=GNB2L1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12102 596.7695 1191.5243 1191.5520 -0.0277 0 45 0.0018 1 R.DETNYGIPQR.A 12103

138. Q9BRF8|CPPED_HUMAN Mass: 35896 Score: 65 Queries matched: 4 emPAI: 0.22 Calcineurin-like phosphoesterase domain-containing protein 1 OS=Homo sapiens GN=CPPED1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3675 422.7514 843.4883 843.5066 -0.0183 0 43 0.0035 1 R.VVVVTAEK.I 3673 7137 474.2469 946.4793 946.5124 -0.0331 0 20 0.63 1 R.TLAAFPAEK.E 12519 607.8340 1213.6534 1213.6666 -0.0132 0 48 0.0009 1 R.LTEQAVQAINK.L

139. P68366|TBA4A_HUMAN Mass: 50634 Score: 65 Queries matched: 5 emPAI: 0.15 Tubulin alpha-4A chain OS=Homo sapiens GN=TUBA4A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6236 455.2489 908.4833 908.4967 -0.0134 1 45 0.0016 1 R.LSVDYGKK.S 6238 9901 535.2935 1068.5724 1068.5815 -0.0091 0 32 0.029 1 K.EIIDPVLDR.I 13884 669.8248 1337.6351 1337.7667 -0.1316 1 2 31 3 K.EIIDPVLDRIR.K 13883

140. P12814|ACTN1_HUMAN Mass: 103563 Score: 64 Queries matched: 6 emPAI: 0.11 Alpha-actinin-1 OS=Homo sapiens GN=ACTN1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2316 413.2289 824.4432 824.4392 0.0040 0 33 0.022 1 R.LDHLAEK.F 2305 7213 474.7809 947.5472 947.5440 0.0032 0 7 12 2 K.SIVNYKPK.I 10835 558.2815 1114.5485 1114.5618 -0.0133 1 33 0.024 1 K.ATLPDADKER.L 11227 567.2995 1132.5845 1132.5659 0.0186 1 1 46 9 K.AETAANRICK.V 14056 677.7909 1353.5672 1353.5983 -0.0311 0 40 0.004 1 K.GISQEQMNEFR.A

141. Q99497|PARK7_HUMAN Mass: 20050 Score: 64 Queries matched: 9 emPAI: 0.69 Protein DJ-1 OS=Homo sapiens GN=PARK7 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2048 408.2500 814.4855 814.4913 -0.0058 0 29 0.085 1 K.VTVAGLAGK.D 4367 433.7449 865.4752 865.5022 -0.0269 0 32 0.034 1 K.VTTHPLAK.D 5258 437.7455 873.4765 873.4920 -0.0154 0 47 0.0014 1 K.DGLILTSR.G 5418 442.2204 882.4261 882.6014 -0.1753 1 3 24 1 K.RALVILAK.G 10793 555.2433 1108.4720 1108.6241 -0.1521 1 8 7.3 6 K.VTTHPLAKDK.M 10787 10797 15157 553.2903 1656.8491 1656.8618 -0.0127 1 30 0.036 1 K.VTVAGLAGKDPVQCSR.D 15158 553.9362 1658.7867 1658.8185 -0.0318 1 10 3.4 1 R.DVVICPDASLEDAKK.E

142. P61088|UBE2N_HUMAN Mass: 17184 Score: 64 Queries matched: 3 emPAI: 0.50 Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens GN=UBE2N PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2688 419.7296 837.4446 837.4054 0.0392 0 6 14 4 R.LYAMNNI.- 9060 518.8045 1035.5944 1035.6328 -0.0384 0 24 0.21 1 R.LLAEPVPGIK.A

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1487 602.2979 1202.5813 1202.5891 -0.0078 0 64 8.1e-005 1 K.TNEAQAIETAR.A

143. P35579|MYH9_HUMAN Mass: 227646 Score: 64 Queries matched: 21 emPAI: 0.10 Myosin-9 OS=Homo sapiens GN=MYH9 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1608 401.2220 800.4294 800.4140 0.0153 0 8 12 9 K.QLAAENR.L 1847 404.7252 807.4358 807.4491 -0.0133 0 35 0.017 1 R.TVGQLYK.E 2520 415.7342 829.4539 829.4545 -0.0006 0 34 0.034 1 K.GALALEEK.R 2715 420.2098 838.4051 838.4007 0.0044 0 16 1.2 1 R.NCAAYLK.L 2721 4308 430.2326 858.4507 858.4447 0.0060 0 15 2.1 1 R.GELANEVK.V 6086 451.2179 900.4212 900.4916 -0.0704 0 2 45 7 R.EEILAQAK.E 6131 452.2549 902.4952 902.5073 -0.0121 0 15 2 1 K.ASITALEAK.I 6530 459.2312 916.4477 916.4614 -0.0136 0 36 0.018 1 K.DLEGLSQR.H 6597 462.7442 923.4739 923.4865 -0.0126 0 29 0.062 1 R.VVFQEFR.Q 6594 6598 7149 474.2739 946.5332 946.4971 0.0361 1 1 45 2 K.KTLEEEAK.T 7425 479.7908 957.5671 957.4403 0.1268 0 8 10 9 K.ADGAEAKPAE.- 7472 481.2376 960.4606 960.4777 -0.0171 0 6 18 6 R.NTNPNFVR.C 1280 503.3634 1004.7123 1004.5185 0.1938 1 9 29 1 K.QRSM AVAAR.K 8480 506.2523 1010.4901 1010.4048 0.0852 0 3 26 5 R.QEEEMM AK.E 10459 546.7749 1091.5353 1091.5499 -0.0146 0 42 0.0031 1 K.FDQLLAEEK.T 12108 597.2996 1192.5846 1192.6088 -0.0242 0 22 0.31 1 K.ALELDSNLYR.I 12351 603.3149 1204.6152 1204.6339 -0.0187 0 21 0.4 1 K.TDLLLEPYNK.Y 13159 633.3082 1264.6018 1264.6333 -0.0315 1 5 15 6 K.LQEMEGTVKSK.Y

144. P09211|GSTP1_HUMAN Mass: 23569 Score: 64 Queries matched: 3 emPAI: 0.16 Glutathione S-transferase P OS=Homo sapiens GN=GSTP1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11352 568.7693 1135.5240 1135.5696 -0.0456 0 51 0.00037 1 K.ASCLYGQLPK.F 11353 11355

145. P50395|GDIB_HUMAN Mass: 51087 Score: 64 Queries matched: 4 emPAI: 0.15 Rab GDP dissociation inhibitor beta OS=Homo sapiens GN=GDI2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6177 453.7259 905.4373 905.4494 -0.0121 0 22 0.41 1 R.TFEGIDPK.K 6167 6923 469.7436 937.4727 937.4869 -0.0142 0 47 0.00092 1 K.LYSESLAR.Y 8851 515.2628 1028.5111 1028.5179 -0.0068 0 45 0.0019 1 K.VTEGSFVYK.G

146. P29350|PTN6_HUMAN Mass: 67918 Score: 63 Queries matched: 53 emPAI: 0.05 Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens GN=PTPN6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2243 412.7461 823.4777 823.3317 0.1461 0 12 3.2 1 K.VMCEGGR.Y 2115 2134 2138 2145 2146 2151 2155 2156 2171 2178 7103 472.7595 943.5044 943.5338 -0.0294 0 4 28 1 K.LEVLQSQK.G 8186 501.2444 1000.4743 1000.4937 -0.0194 0 63 2.8e-005 1 R.VNAADIENR.V 12314 599.7880 1197.5614 1197.5989 -0.0375 0 25 0.17 1 K.NQLLGPDENAK.T

147. P48643|TCPE_HUMAN Mass: 60089 Score: 63 Queries matched: 3 emPAI: 0.13 T-complex protein 1 subunit epsilon OS=Homo sapiens GN=CCT5 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6596 462.7265 923.4385 923.4600 -0.0215 0 33 0.027 1 R.FSELTAEK.L 10497 547.2553 1092.4961 1092.5200 -0.0239 0 50 0.00051 1 R.IADGYEQAAR.V 12379 603.3307 1204.6468 1204.6121 0.0347 1 2 34 1 R.GGNKMIIEEAK.R

148. P25788|PSA3_HUMAN Mass: 28643 Score: 63 Queries matched: 3 emPAI: 0.13 Proteasome subunit alpha type-3 OS=Homo sapiens GN=PSMA3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6543 460.2313 918.4480 918.5035 -0.0556 1 8 11 5 K.RLFNVDR.H 6544 12532 609.3113 1216.6080 1216.6411 -0.0332 0 63 2.7e-005 1 K.AVENSSTAIGIR.C

149. P07437|TBB5_HUMAN Mass: 50095 Score: 63 Queries matched: 5 emPAI: 0.15 Tubulin beta chain OS=Homo sapiens GN=TUBB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8840 514.7536 1027.4926 1027.5121 -0.0194 0 56 0.00014 1 K.TAVCDIPPR.G 8842 9821 533.2423 1064.4700 1064.4201 0.0498 0 4 20 10 K.NMMAACDPR.H 1375 13544 651.3186 1300.6226 1300.6299 -0.0073 0 32 0.029 1 R.ISVYYNEATGGK.Y

150. P61769|B2MG_HUMAN Mass: 13820 Score: 62 Queries matched: 5 emPAI: 0.65 Beta-2-microglobulin OS=Homo sapiens GN=B2M PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2053 408.7278 815.4410 815.4654 -0.0243 1 12 4.6 1 K.IVKWDR.D 10986 561.8030 1121.5914 1121.6193 -0.0279 0 51 0.00047 1 R.VNHVTLSQPK.I 10988 11496 574.7610 1147.5075 1147.5509 -0.0435 0 37 0.0098 1 K.VEHSDLSFSK.D 14929 506.9283 1517.7630 1517.7726 -0.0095 1 8 7.4 1 R.IEKVEHSDLSFSK.D

151. Q00610|CLH1_HUMAN Mass: 193260 Score: 61 Queries matched: 10 emPAI: 0.04 Clathrin heavy chain 1 OS=Homo sapiens GN=CLTC PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2377 413.2447 824.4748 824.4796 -0.0048 0 17 0.96 1 R.IAAYLFK.G 2436 414.7368 827.4590 827.4177 0.0413 0 14 2.5 3 R.AVNYFSK.V 5499 443.2043 884.3940 884.4028 -0.0088 0 22 0.31 1 R.AYEFAER.C 5501 5684 445.7284 889.4423 889.4505 -0.0082 0 6 16 5 K.LDASESLR.K 6922 469.7405 937.4665 937.4756 -0.0091 0 26 0.13 1 K.EAIDSYIK.A 1349 522.2241 1042.4336 1042.4356 -0.0020 0 21 1.3 1 R.ENPYYDSR.V 9624 530.2560 1058.4975 1058.5720 -0.0745 1 1 45 5 K.TGQIKEVER.I 12045 592.7529 1183.4912 1183.5002 -0.0089 0 31 0.038 1 K.EVCFACVDGK.E 1527 667.8075 1333.6004 1333.6262 -0.0258 0 60 5e-005 1 K.IYIDSNNNPER.F

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152. P13489|RINI_HUMAN Mass: 51766 Score: 61 Queries matched: 3 emPAI: 0.15 Ribonuclease inhibitor OS=Homo sapiens GN=RNH1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2544 416.2299 830.4452 830.4498 -0.0046 0 24 0.27 1 R.ELALGSNK.L 7478 481.7405 961.4664 961.4903 -0.0239 0 37 0.013 1 R.DLCGIVASK.A 11499 575.2543 1148.4940 1148.5132 -0.0192 0 47 0.0011 1 R.LDDCGLTEAR.C

153. P63218|GBG5_HUMAN Mass: 7428 Score: 61 Queries matched: 1 emPAI: 0.56 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens GN=GNG5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6114 451.7444 901.4743 901.4869 -0.0126 0 61 6.3e-005 1 K.VSQAAADLK.Q

154. P55072|TERA_HUMAN Mass: 89950 Score: 60 Queries matched: 137 emPAI: 0.08 Transitional endoplasmic reticulum ATPase OS=Homo sapiens GN=VCP PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 327 419.2873 836.5601 836.5232 0.0369 0 26 0.4 1 K.AIGVKPPR.G 5050 435.7681 869.5217 869.5195 0.0022 1 13 2.6 1 R.VVRNNLR.V 4701 4704 4707 4708 4750 4766 4772 4787 4794 4795 47 8124 499.3034 996.5922 996.6444 -0.0522 1 6 13 4 R.VAILKANLR.K 8303 501.7791 1001.5437 1001.5215 0.0221 0 7 13 1 K.EM VELPLR.H 10111 538.2649 1074.5152 1074.5305 -0.0153 0 44 0.0021 1 K.LAGESESNLR.K 10888 559.7805 1117.5465 1117.5727 -0.0262 1 5 17 5 R.ESIESEIRR.E 10890 12878 621.8046 1241.5946 1241.6252 -0.0306 0 43 0.0028 1 R.EVDIGIPDATGR.L

155. Q15149|PLEC1_HUMAN Mass: 533462 Score: 60 Queries matched: 96 emPAI: 0.03 Plectin-1 OS=Homo sapiens GN=PLEC1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1534 692.3732 691.3659 691.3323 0.0336 0 15 2.5 1 R.VAEMSR.A 2436 414.7368 827.4590 827.4865 -0.0274 0 14 2.3 2 R.VAQLLER.W 5228 437.2666 872.5186 872.4967 0.0219 0 8 12 3 R.LTVNEAVK.E 5230 437.2691 872.5236 872.4352 0.0885 0 5 25 1 K.QVAEEAAR.L 5234 5317 439.1998 876.3850 876.4705 -0.0855 0 7 13 1 K.ATVSAPFGK.F 6000 450.2566 898.4987 898.5348 -0.0361 1 9 6.4 9 R.RDVQLIR.S 6006 6028 6037 6093 451.2488 900.4831 900.5644 -0.0813 0 4 26 4 R.SSIAGLLLK.A 6094 451.2570 900.4994 900.5029 -0.0034 0 13 3.2 1 K.LAAIGEATR.L 6116 451.7449 901.4752 901.4869 -0.0117 0 8 10 1 R.LTVDEAVR.A 6110 6117 451.7449 901.4752 901.4253 0.0498 0 6 19 10 K.ELQNAGDR.L 6126 451.7666 901.5187 901.4869 0.0318 0 2 49 7 K.GLVEDTLR.Q 6163 453.6998 905.3851 905.4753 -0.0902 1 5 22 1 K.SM IIDRR.S 6241 455.7512 909.4879 909.5760 -0.0881 0 20 0.52 2 K.AVVQLKPR.H 6240 6477 458.2751 914.5356 914.5185 0.0171 0 26 0.16 3 K.GLLSAEVAR.L 6538 459.7499 917.4852 917.4971 -0.0119 0 31 0.046 1 R.VPVDVAYR.R 7760 488.2612 974.5079 974.4304 0.0775 0 10 7 5 R.AAEEAEEAR.V 7824 490.2566 978.4986 978.4692 0.0295 0 7 12 5 R.VQMEELSK.L 7990 495.2598 988.5050 988.5441 -0.0391 0 8 9.3 7 R.SELELTLGK.L 8542 508.2717 1014.5288 1014.5458 -0.0170 0 35 0.019 1 R.LSVAAQEAAR.L 8756 512.2464 1022.4782 1022.5648 -0.0866 0 8 8.1 9 R.SLSAIYLEK.L 8757 8761 9624 530.2560 1058.4975 1058.5356 -0.0382 0 36 0.013 1 R.GTQGAEEVLR.A 9647 530.7617 1059.5089 1059.5084 0.0005 0 30 0.07 1 R.VLADPSDDTK.G 9996 537.2749 1072.5352 1072.6029 -0.0677 0 10 7 3 K.SLLAWQSLR.R 9952 9980 9983 9989 9992 9997 10006 10014 10018 10415 545.7573 1089.5000 1089.5740 -0.0740 0 (13) 2.7 4 R.AEMEVLLASK.A 10410 10412 10418 10420 1403 10421 10423 1418 553.7508 1105.4870 1105.5689 -0.0819 0 15 1.8 3 R.AEMEVLLASK.A 10617 10619 10620 10621 10622 10623 10627 10630 10655 553.7800 1105.5454 1105.6720 -0.1266 1 11 4.7 7 R.LHERLVAIR.T 10646 10652 10654 10943 561.2695 1120.5245 1120.5261 -0.0016 1 4 23 3 R.AEEDAQRFR.K 11197 566.7453 1131.4759 1131.4655 0.0105 0 15 1.9 2 R.GYFSEEMNR.V 11198 11201 11202 11203 11204 11205 11206 11207 1 11459 572.3029 1142.5913 1142.5931 -0.0018 0 7 10 1 R.LQAEEVAQQK.S 11481 573.2731 1144.5316 1144.5585 -0.0269 1 2 37 2 R.RQVQDESQR.K 1464 580.7491 1159.4837 1159.4604 0.0233 0 1 41 3 R.GYFDEEMNR.V 11725 582.3048 1162.5951 1162.5288 0.0664 0 9 6 3 R.QLEMSAEAER.L 12017 590.2945 1178.5744 1178.5601 0.0143 1 3 27 6 R.DLDKADSMIR.L 12011 12661 613.2838 1224.5531 1224.5847 -0.0316 1 2 29 9 R.HGERDVEVER.W 12882 622.3294 1242.6442 1242.6680 -0.0238 1 5 14 3 R.LQLEATERQR.G 13513 650.3775 1298.7404 1298.7063 0.0341 1 2 27 2 R.RPVAMVM PARR.T 13721 439.5345 1315.5817 1315.5615 0.0202 1 1 36 4 R.RGYFDEEMNR.V 1527 667.8075 1333.6004 1333.7605 -0.1601 0 3 24 5 R.IISLETYNLLR.E 14292 462.2247 1383.6521 1383.7470 -0.0949 1 6 12 3 K.AQAEVEGLGKGVAR.L

156. P07602|SAP_HUMAN Mass: 59899 Score: 59 Queries matched: 5 emPAI: 0.13 Proactivator polypeptide OS=Homo sapiens GN=PSAP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2646 418.2303 834.4459 834.4599 -0.0140 0 36 0.017 1 K.LVGYLDR.N 2644 2645 5351 440.2425 878.4705 878.4354 0.0351 1 5 20 7 K.MCSKLPK.S 13688 656.2819 1310.5493 1310.5965 -0.0472 0 39 0.0057 1 K.GCSFLPDPYQK.Q

157. Q16543|CDC37_HUMAN Mass: 44953 Score: 59 Queries matched: 1 emPAI: 0.08 Hsp90 co-chaperone Cdc37 OS=Homo sapiens GN=CDC37 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9576 528.7840 1055.5535 1055.5723 -0.0188 0 59 7.1e-005 1 R.LQAEAQQLR.K

158. Q99832|TCPH_HUMAN Mass: 59842 Score: 59 Queries matched: 51 emPAI: 0.06 T-complex protein 1 subunit eta OS=Homo sapiens GN=CCT7 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2005 406.2528 810.4910 810.4963 -0.0053 0 12 2.8 1 K.ALEIIPR.Q 7118 473.2513 944.4880 944.5291 -0.0410 0 59 9e-005 1 R.TATQLAVNK.I 9225 523.2706 1044.5267 1044.5200 0.0067 0 8 9.7 10 R.STVDAPTAAGR.G 9217 9220 9238 9247 9261 9270

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9248 523.2743 1044.5340 1044.5199 0.0140 1 12 3.9 8 K.AEKDNAEIR.V 9211 9218 9219 9222 9223 9224 9229 9230 9233 9239 10592 552.2952 1102.5758 1102.5805 -0.0047 1 23 0.33 2 R.GMDKLIVDGR.G 10603 552.7703 1103.5261 1103.6339 -0.1078 0 3 28 9 K.QQLLIGAYAK.A 362 420.2416 1257.7029 1257.6426 0.0603 1 13 7.8 1 R.STVDAPTAAGRGR.G 339 340 342 343 344 345 348 349 350 351 352 357

159. Q14210|LY6D_HUMAN Mass: 13848 Score: 57 Queries matched: 1 emPAI: 0.28 Lymphocyte antigen 6D OS=Homo sapiens GN=LY6D PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8904 515.7694 1029.5242 1029.5455 -0.0213 0 57 0.00012 1 K.TTNTVEPLR.G

160. P25789|PSA4_HUMAN Mass: 29750 Score: 56 Queries matched: 3 emPAI: 0.27 Proteasome subunit alpha type-4 OS=Homo sapiens GN=PSMA4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6125 451.7577 901.5009 901.5233 -0.0224 0 39 0.0096 1 K.VEIATLTR.E 6111 8458 504.2459 1006.4772 1006.5084 -0.0312 0 48 0.00094 1 R.TTIFSPEGR.L

161. P15144|AMPN_HUMAN Mass: 109870 Score: 56 Queries matched: 10 emPAI: 0.07 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5573 443.7542 885.4939 885.5032 -0.0093 0 16 1.6 3 K.IQTQLQR.D 6092 451.2420 900.4694 900.4916 -0.0222 0 35 0.022 1 R.ALEQALEK.T 1170 479.2367 956.4589 956.5403 -0.0814 0 4 54 3 K.QASNGVLIR.I 7303 8510 507.7346 1013.4547 1013.5869 -0.1323 0 4 24 4 R.SIQLPTTVR.D 9639 530.7434 1059.4723 1059.5423 -0.0700 1 5 21 3 -.MAKGFYISK.S 9640 10249 542.7350 1083.4553 1083.4655 -0.0101 0 4 20 8 R.SEYMEGNVR.K 10938 561.2500 1120.4854 1120.5989 -0.1135 0 6 14 10 R.DHSAIPVINR.A 13280 635.2717 1268.5288 1268.5269 0.0018 0 46 0.00092 1 K.DNEETGFGSGTR.A

162. P62826|RAN_HUMAN Mass: 24579 Score: 56 Queries matched: 4 emPAI: 0.33 GTP-binding nuclear protein Ran OS=Homo sapiens GN=RAN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8558 508.2799 1014.5452 1014.5710 -0.0258 0 41 0.0049 1 K.LVLVGDGGTGK.T 8561 8562 12516 607.7805 1213.5464 1213.5979 -0.0515 0 36 0.013 1 K.NLQYYDISAK.S

163. P22392|NDKB_HUMAN Mass: 17401 Score: 55 Queries matched: 9 emPAI: 0.22 Nucleoside diphosphate kinase B OS=Homo sapiens GN=NME2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 280 414.7534 827.4922 827.5116 -0.0194 0 9 7 3 R.GLVGEIIK.R 9548 526.2310 1050.4475 1050.4917 -0.0442 0 52 0.00031 1 R.GDFCIQVGR.N 9549 9551 9556 9900 535.2712 1068.5278 1068.5564 -0.0286 0 26 0.14 1 R.NIIHGSDSVK.S 13968 448.9097 1343.7074 1343.7561 -0.0487 0 13 2.4 1 R.TFIAIKPDGVQR.G 13967 13969

164. P06744|G6PI_HUMAN Mass: 63335 Score: 54 Queries matched: 8 emPAI: 0.19 Glucose-6-phosphate isomerase OS=Homo sapiens GN=GPI PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1681 403.2261 804.4377 804.4415 -0.0038 0 38 0.011 1 R.M LVDLAK.S 3678 423.1917 844.3688 844.3926 -0.0238 0 26 0.2 1 K.SPEDLER.L 3912 426.7124 851.4103 851.4137 -0.0034 0 25 0.15 1 K.INYTEGR.A 7137 474.2469 946.4793 946.4430 0.0363 0 7 11 2 K.DVMPEVNK.V 7174 9189 522.2815 1042.5484 1042.5659 -0.0174 0 43 0.0028 1 R.SNTPILVDGK.D 9155 1387 538.7449 1075.4752 1075.5332 -0.0580 0 2 38 8 K.NLVTEDVMR.M

165. P11413|G6PD_HUMAN Mass: 59675 Score: 54 Queries matched: 16 emPAI: 0.13 Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens GN=G6PD PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4342 432.2106 862.4066 862.4185 -0.0119 0 26 0.18 1 K.LPDAYER.L 5403 441.7145 881.4145 881.4283 -0.0138 0 20 0.52 1 K.QSEPFFK.A 5697 446.6989 891.3833 891.4086 -0.0253 0 17 1.3 1 K.EPFGTEGR.G 10707 553.8215 1105.6283 1105.4961 0.1322 0 1 42 1 R.GPTEADELMK.R 10696 11214 566.7748 1131.5350 1131.5560 -0.0210 0 44 0.0023 1 K.GYLDDPTVPR.G 11197 11199 11200 11201 11204 11205 11206 11209 11498 574.7894 1147.5642 1147.5873 -0.0231 0 31 0.04 1 R.VQPNEAVYTK.M 12899 623.8034 1245.5923 1245.6023 -0.0100 1 5 15 3 R.GPTEADELMKR.V

166. P02654|APOC1_HUMAN Mass: 9326 Score: 54 Queries matched: 1 emPAI: 0.43 Apolipoprotein C-I OS=Homo sapiens GN=APOC1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8359 502.2842 1002.5539 1002.5709 -0.0170 1 54 0.00022 1 R.IKQSELSAK.M

167. Q08554|DSC1_HUMAN Mass: 101406 Score: 54 Queries matched: 4 emPAI: 0.07 Desmocollin-1 OS=Homo sapiens GN=DSC1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5217 437.2562 872.4979 872.5080 -0.0100 1 1 63 3 K.DGKTAILR.Q 8362 502.7454 1003.4762 1003.5008 -0.0246 0 27 0.13 1 K.VNLEECLK.S 10249 542.7350 1083.4553 1083.4655 -0.0102 0 38 0.0077 1 K.DTGDIFCTR.S 15170 561.9402 1682.7987 1682.8112 -0.0125 0 40 0.0039 1 K.VTATDLDEPDTLHTR.L

168. P28072|PSB6_HUMAN Mass: 25570 Score: 54 Queries matched: 1 emPAI: 0.15 Proteasome subunit beta type-6 OS=Homo sapiens GN=PSMB6 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10245 542.2655 1082.5164 1082.5356 -0.0192 0 54 0.00022 1 R.TTTGSYIANR.V

169. P62913|RL11_HUMAN Mass: 20468 Score: 53 Queries matched: 5 emPAI: 0.41

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60S ribosomal protein L11 OS=Homo sapiens GN=RPL11 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2524 416.2095 830.4044 830.4385 -0.0341 0 42 0.0047 1 K.AEEILEK.G 308 7259 478.2496 954.4847 954.5069 -0.0223 0 6 11 7 K.IAVHCTVR.G 7483 482.2441 962.4736 962.4855 -0.0119 1 15 2 2 R.ISKEEAMR.W 7761 488.2657 974.5168 974.5437 -0.0268 0 37 0.013 1 K.YDGIILPGK.-

170. P35580|MYH10_HUMAN Mass: 229827 Score: 52 Queries matched: 10 emPAI: 0.03 Myosin-10 OS=Homo sapiens GN=MYH10 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1847 404.7252 807.4358 807.4491 -0.0133 0 35 0.017 1 R.TVGQLYK.E 2715 420.2098 838.4051 838.4007 0.0044 0 16 1.2 1 R.NCAAYLK.L 2721 434 421.7504 841.4862 841.5134 -0.0272 1 3 25 6 R.AAANKLVR.R 3784 425.2251 848.4356 848.4756 -0.0400 1 6 14 5 R.FKANLEK.N 7472 481.2376 960.4606 960.4777 -0.0171 0 6 18 6 R.NTNPNFVR.C 10459 546.7749 1091.5353 1091.5499 -0.0146 0 42 0.0031 1 K.FDQLLAEEK.S 10832 558.2565 1114.4984 1114.5618 -0.0634 0 5 19 8 K.EEELQGALAR.G 11667 581.2535 1160.4925 1160.5859 -0.0934 1 12 3.2 3 K.AMVNKDDIQK.M 12971 626.2225 1250.4305 1250.6255 -0.1950 1 5 7.7 1 R.ASRDEIFAQSK.E

171. Q7Z406|MYH14_HUMAN Mass: 228889 Score: 52 Queries matched: 8 emPAI: 0.03 Myosin-14 OS=Homo sapiens GN=MYH14 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1847 404.7252 807.4358 807.4491 -0.0133 0 35 0.017 1 R.TVGQLYK.E 2715 420.2098 838.4051 838.4007 0.0044 0 16 1.2 1 R.NCAAYLK.L 2721 5645 444.7494 887.4842 887.4461 0.0381 1 7 15 2 R.AVEERER.A 6531 459.2434 916.4722 916.4250 0.0472 0 13 3.2 1 R.LGEEDAGAR.A 1294 508.2461 1014.4776 1014.5458 -0.0681 1 4 60 6 R.AEAAEKLQR.A 10459 546.7749 1091.5353 1091.5499 -0.0146 0 42 0.0031 1 K.FDQLLAEEK.A 11454 571.7614 1141.5082 1141.6203 -0.1121 1 2 36 6 R.AEELRAQLGR.K

172. P08865|RSSA_HUMAN Mass: 32947 Score: 51 Queries matched: 4 emPAI: 0.24 40S ribosomal protein SA OS=Homo sapiens GN=RPSA PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6299 456.7651 911.5156 911.5440 -0.0284 0 41 0.0033 1 R.LLVVTDPR.A 6316 9704 531.2646 1060.5147 1060.5587 -0.0439 0 11 4.4 1 M.SGALDVLQMK.E 12338 602.3063 1202.5980 1202.6408 -0.0428 0 36 0.014 1 K.FAAATGATPIAGR.F

173. O75874|IDHC_HUMAN Mass: 46915 Score: 51 Queries matched: 4 emPAI: 0.17 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens GN=IDH1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 69 404.2119 806.4093 806.4286 -0.0193 1 22 2.4 2 K.RVEEFK.L 6464 457.7779 913.5412 913.5596 -0.0184 1 8 9.2 3 K.LGENLKIK.L 10295 544.2930 1086.5714 1086.5710 0.0004 0 35 0.021 1 R.ATDFVVPGPGK.V 14557 719.8501 1437.6856 1437.6987 -0.0131 0 40 0.0047 1 K.VEITYTPSDGTQK.V

174. P30050|RL12_HUMAN Mass: 17979 Score: 51 Queries matched: 4 emPAI: 0.21 60S ribosomal protein L12 OS=Homo sapiens GN=RPL12 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5402 441.2709 880.5273 880.5382 -0.0109 0 47 0.00083 1 K.IGPLGLSPK.K 792 5401 793

175. Q8TCU5|NMD3A_HUMAN Mass: 126525 Score: 51 Queries matched: 646 emPAI: 0.03 Glutamate [NMDA] receptor subunit 3A OS=Homo sapiens GN=GRIN3A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3485 421.7542 841.4938 841.4446 0.0492 0 33 0.024 1 R.AEALWPR.D 2858 2859 2864 2868 2869 2876 2877 2878 2882 2883 2886 6490 458.7464 915.4781 915.5502 -0.0720 1 8 11 6 R.GLSGSIRVK.G

176. P09496|CLCA_HUMAN Mass: 27174 Score: 50 Queries matched: 2 emPAI: 0.30 Clathrin light chain A OS=Homo sapiens GN=CLTA PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5712 447.2036 892.3927 892.4113 -0.0186 0 15 2 1 R.LCDFNPK.S 7974 494.7495 987.4844 987.4985 -0.0141 0 58 0.00011 1 R.LEALDANSR.K

177. O00175|CCL24_HUMAN Mass: 13467 Score: 49 Queries matched: 2 emPAI: 0.29 C-C motif chemokine 24 OS=Homo sapiens GN=CCL24 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9098 519.7742 1037.5339 1037.5506 -0.0167 0 40 0.0048 1 R.VVSYQLSSR.S 9099

178. P29508|SPB3_HUMAN Mass: 44594 Score: 49 Queries matched: 5 emPAI: 0.17 Serpin B3 OS=Homo sapiens GN=SERPINB3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 579 431.2534 860.4921 860.5007 -0.0086 0 8 39 1 K.VLEIPYK.G 4344 432.7389 863.4633 863.4752 -0.0120 0 26 0.15 1 K.LLTEFNK.S 6603 463.7285 925.4423 925.4393 0.0031 0 24 0.17 1 K.STDAYELK.I 6837 466.7360 931.4573 931.4512 0.0062 0 38 0.0091 1 K.AATYHVDR.S 9903 535.7756 1069.5367 1069.5556 -0.0189 0 40 0.0057 1 K.TNSILFYGR.F

Proteins matching the same set of peptides: P48594|SPB4_HUMAN Mass: 44997 Score: 49 Queries matched: 5 Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2

179. O60234|GMFG_HUMAN Mass: 16961 Score: 49 Queries matched: 4 emPAI: 0.23 Glia maturation factor gamma OS=Homo sapiens GN=GMFG PE=1 SV=1

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6150 453.2235 904.4323 904.4695 -0.0371 0 21 0.5 1 R.FVVYSYK.Y 8300 501.7766 1001.5386 1001.5757 -0.0371 0 50 0.00065 1 R.LVQTAELTK.V 8295 1267

180. P06899|H2B1J_HUMAN Mass: 13896 Score: 49 Queries matched: 5 emPAI: 0.28 Histone H2B type 1-J OS=Homo sapiens GN=HIST1H2BJ PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2051 408.7203 815.4260 815.4501 -0.0241 0 24 0.32 1 R.EIQTAVR.L 2052 7251 477.3006 952.5867 952.5957 -0.0090 0 48 0.00086 1 R.LLLPGELAK.H 7250 1195 484.7587 967.5029 967.5338 -0.0310 1 5 16 8 K.AVTKYTSAK.-

Proteins matching the same set of peptides: P57053|H2BFS_HUMAN Mass: 13936 Score: 49 Queries matched: 5 Histone H2B type F-S OS=Homo sapiens GN=H2BFS PE=1 SV=2 O60814|H2B1K_HUMAN Mass: 13882 Score: 49 Queries matched: 5 Histone H2B type 1-K OS=Homo sapiens GN=HIST1H2BK PE=1 SV=3

181. Q15942|ZYX_HUMAN Mass: 62436 Score: 48 Queries matched: 1 emPAI: 0.06 Zyxin OS=Homo sapiens GN=ZYX PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10143 538.7848 1075.5551 1075.5662 -0.0111 0 48 0.00094 1 R.GPPASSPAPAPK.F

182. P15121|ALDR_HUMAN Mass: 36230 Score: 48 Queries matched: 4 emPAI: 0.22 Aldose reductase OS=Homo sapiens GN=AKR1B1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5703 446.7398 891.4651 891.4814 -0.0163 0 29 0.082 1 K.VAIDVGYR.H 6097 451.2704 900.5261 900.5393 -0.0131 0 45 0.0024 1 K.TTAQVLIR.F 9104 520.2568 1038.4990 1038.5168 -0.0178 0 10 5.9 1 K.LIQYCQSK.G 10837 558.2851 1114.5557 1114.6209 -0.0652 0 11 4.2 9 K.MPILGLGTWK.S

183. P15104|GLNA_HUMAN Mass: 42665 Score: 47 Queries matched: 3 emPAI: 0.29 Glutamine synthetase OS=Homo sapiens GN=GLUL PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7265 478.7635 955.5124 955.5199 -0.0075 0 35 0.015 1 R.RPAETNLR.H 8087 497.7505 993.4864 993.5018 -0.0155 0 33 0.024 1 K.YIEEAIEK.L 1266 501.7508 1001.4871 1001.4930 -0.0059 0 31 0.048 1 R.DIVEAHYR.A

184. O15078|CE290_HUMAN Mass: 290892 Score: 47 Queries matched: 38 emPAI: 0.01 Centrosomal protein of 290 kDa OS=Homo sapiens GN=CEP290 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1653 401.7292 801.4439 801.4344 0.0095 0 4 28 4 K.ILAENSR.K 1657 402.2049 802.3953 802.4185 -0.0232 0 47 0.0016 1 R.EISDIAR.R 2520 415.7342 829.4539 829.4909 -0.0369 1 11 6 9 K.LKAELEK.L 3695 423.2659 844.5171 844.4906 0.0266 0 1 54 4 R.EIEILTK.E 3796 425.7318 849.4490 849.3902 0.0588 0 11 5.5 7 K.QLEEGMK.E 3797 3806 425.7508 849.4871 849.4344 0.0527 0 9 7.7 1 R.LQFAESR.G 5279 437.7638 873.5130 873.4192 0.0938 0 11 5.4 7 K.NAQLDADK.S 6495 458.7534 915.4923 915.4774 0.0149 1 2 44 9 K.QLEQKDR.E 7130 473.7532 945.4918 945.4767 0.0151 0 22 0.36 1 K.EQVESINK.E 7132 7666 487.7357 973.4569 973.5192 -0.0623 1 3 33 8 K.KVSQDLER.Q 7831 490.7671 979.5196 979.4280 0.0915 0 6 13 5 K.LGNESSMDK.A 8586 509.2855 1016.5563 1016.4999 0.0564 1 1 47 10 K.AVSDADRQR.I 9163 522.2595 1042.5044 1042.6022 -0.0978 0 18 1 1 K.ITVLQVNEK.S 9161 9162 9164 9165 9166 9168 9169 9174 9180 9181 9182 522.2705 1042.5265 1042.5771 -0.0506 0 16 1.3 2 R.LAEQNILSR.D 9171 9178 10372 545.3055 1088.5965 1088.5172 0.0793 1 4 24 1 K.EMQKDPDVK.G 10533 548.2737 1094.5328 1094.5828 -0.0500 1 12 3.2 4 R.ITQSLMKMK.A 11243 567.3116 1132.6086 1132.5248 0.0838 0 0 51 1 K.EIESLEEER.L 11583 576.2665 1150.5185 1150.5540 -0.0355 0 8 8.5 2 K.MTVQLEETGK.R 12205 598.3211 1194.6276 1194.5550 0.0726 1 4 20 4 K.LGNESSMDKAK.K 13956 672.3907 1342.7669 1342.8071 -0.0403 1 0 41 6 K.LKGLEELISTLK.D 14316 464.5550 1390.6433 1390.7667 -0.1234 1 0 44 5 K.KSITNSDIVSISK.K 14501 711.3241 1420.6336 1420.7423 -0.1087 0 2 25 7 K.EAHLNVQQIVDR.H

185. Q5TZA2|CROCC_HUMAN Mass: 228787 Score: 46 Queries matched: 23 emPAI: 0.02 Rootletin OS=Homo sapiens GN=CROCC PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 457 422.7318 843.4491 843.4450 0.0041 0 23 0.37 1 R.LEQEVAR.Q 6168 453.7232 905.4318 905.4454 -0.0136 0 9 8.9 2 R.TLSEEATR.L 6460 457.7568 913.4990 913.5232 -0.0243 0 46 0.0013 1 K.LALLEEAR.T 1090 466.2681 930.5217 930.5022 0.0195 0 12 12 2 K.AEVAEALTK.A 8199 501.2746 1000.5346 1000.5553 -0.0207 1 6 16 1 R.LEKQNLEK.D 8233 8241 8255 11627 579.2907 1156.5668 1156.6200 -0.0532 1 13 2.5 2 R.LLEDARDGLR.R 11609 11610 11613 11618 11619 11623 11624 1162 12631 611.8139 1221.6132 1221.6387 -0.0255 1 2 33 4 K.TALSEKLMGTR.H 12737 617.2891 1232.5636 1232.6434 -0.0798 1 2 29 9 K.ASLDKELMAQK.L 499 426.2333 1275.6781 1275.6605 0.0176 0 0 1.1e+002 1 R.SASLAQVNAMLR.E 13505 650.3741 1298.7336 1298.7194 0.0142 1 2 29 4 K.EQKLALLEEAR.T 14544 477.9423 1430.8050 1430.7551 0.0498 1 1 35 1 K.ELMAQKLVQAER.E

186. Q9UNF0|PACN2_HUMAN Mass: 56046 Score: 46 Queries matched: 8 emPAI: 0.07 Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens GN=PACSIN2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7240 476.2313 950.4480 950.4457 0.0023 1 6 14 1 K.EAEDGFRK.A 1171 479.2570 956.4994 956.5542 -0.0548 0 14 5.7 1 R.EVLLEVQK.H 7428 480.2291 958.4436 958.4720 -0.0283 0 46 0.0015 1 R.AADAVEDLR.W 11830 585.2589 1168.5032 1168.5070 -0.0038 0 (2) 34 6 K.ASLMNDDFEK.I

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12067 593.3397 1184.6649 1184.5019 0.1630 0 7 12 2 K.ASLMNDDFEK.I 12061 12063 12068

187. P30101|PDIA3_HUMAN Mass: 57146 Score: 46 Queries matched: 1 emPAI: 0.07 Protein disulfide-isomerase A3 OS=Homo sapiens GN=PDIA3 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12101 596.2901 1190.5657 1190.5931 -0.0274 0 46 0.0012 1 R.LAPEYEAAATR.L

188. P22314|UBA1_HUMAN Mass: 118858 Score: 45 Queries matched: 11 emPAI: 0.03 Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1350 522.2471 521.2398 521.2268 0.0131 0 7 15 1 K.ACSGK.F 2034 407.2603 812.5060 812.5120 -0.0059 0 4 21 3 K.NIILGGVK.A 3952 426.7408 851.4670 851.4059 0.0612 0 2 31 1 -.MSSSPLSK.K 3931 3938 3942 3970 6818 466.2645 930.5145 930.5208 -0.0063 0 13 3.6 1 K.SIPICTLK.N 12967 625.7834 1249.5523 1249.5575 -0.0051 0 45 0.0014 1 R.AENYDIPSADR.H 13400 644.8303 1287.6460 1287.6493 -0.0033 0 13 2.5 4 R.LDQPMTEIVSR.V 13401

189. P08571|CD14_HUMAN Mass: 40678 Score: 45 Queries matched: 2 emPAI: 0.09 Monocyte differentiation antigen CD14 OS=Homo sapiens GN=CD14 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4285 429.7270 857.4395 857.3879 0.0516 0 4 30 6 R.VDADADPR.Q 6254 456.7455 911.4764 911.4825 -0.0061 0 45 0.0014 1 R.ATVNPSAPR.C

190. O00182|LEG9_HUMAN Mass: 39835 Score: 45 Queries matched: 2 emPAI: 0.09 Galectin-9 OS=Homo sapiens GN=LGALS9 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2425 414.2203 826.4260 826.4661 -0.0401 0 18 0.83 1 R.NLPTINR.L 7215 475.2301 948.4456 948.4665 -0.0209 0 45 0.002 1 R.FDENAVVR.N

191. P01034|CYTC_HUMAN Mass: 16017 Score: 44 Queries matched: 3 emPAI: 0.24 Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6250 456.7225 911.4304 911.5665 -0.1361 1 5 13 1 R.ALQVVRAR.K 6251 12666 613.7913 1225.5681 1225.5979 -0.0298 0 44 0.0018 1 R.ALDFAVGEYNK.A

192. O60437|PEPL_HUMAN Mass: 205124 Score: 44 Queries matched: 32 emPAI: 0.02 Periplakin OS=Homo sapiens GN=PPL PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2495 415.7208 829.4271 829.4545 -0.0273 0 16 2.1 2 R.VAALAEEK.S 2492 2493 2510 2518 5302 438.2557 874.4967 874.4144 0.0823 0 3 37 5 R.AVQDSAER.A 5634 444.7134 887.4123 887.4712 -0.0590 1 17 1.3 1 R.ELDDLKR.L 5626 5628 5629 5631 5632 5635 5812 448.2439 894.4731 894.4745 -0.0014 1 0 49 3 -.MNSLFRK.R 6306 456.7670 911.5194 911.5189 0.0005 1 27 0.084 1 R.RGPQVEVK.E 7568 486.2564 970.4982 970.5560 -0.0577 1 3 27 2 R.ARLQSPATK.V 8004 495.7741 989.5336 989.4890 0.0446 1 15 1.8 3 R.TRVEDTNR.K 8006 8007 8907 516.2555 1030.4964 1030.5043 -0.0079 0 44 0.0022 1 R.ASQEEQIAR.K 9181 522.2698 1042.5250 1042.5771 -0.0521 1 8 8.1 9 K.VDVANRLEK.S 9161 9162 9164 9165 9166 9168 9169 9174 9188 9916 536.2486 1070.4827 1070.6335 -0.1508 1 5 18 4 K.LAALEKAEVK.E 15097 402.4756 1605.8734 1605.8250 0.0484 1 2 24 1 K.QEEELSFLQDKLK.R

193. P15880|RS2_HUMAN Mass: 31590 Score: 44 Queries matched: 2 emPAI: 0.12 40S ribosomal protein S2 OS=Homo sapiens GN=RPS2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8815 513.2843 1024.5541 1024.5917 -0.0376 0 44 0.0018 1 R.GTGIVSAPVPK.K 8811

194. P84098|RL19_HUMAN Mass: 23565 Score: 44 Queries matched: 5 emPAI: 0.16 60S ribosomal protein L19 OS=Homo sapiens GN=RPL19 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5695 446.2443 890.4739 890.5007 -0.0268 1 3 30 6 M.SMLRLQK.R 1231 493.7507 985.4868 985.5192 -0.0324 0 44 0.0023 1 K.LLADQAEAR.R 9639 530.7434 1059.4723 1059.6175 -0.1452 1 7 14 2 K.EEIIKTLSK.E 9637 9640

195. P02788|TRFL_HUMAN Mass: 80014 Score: 44 Queries matched: 3 emPAI: 0.05 Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3913 426.7133 851.4120 851.4137 -0.0017 0 1 39 10 K.DSAIGFSR.V 1169 478.7783 955.5420 955.5563 -0.0143 1 0 52 6 K.RKPVTEAR.S 8685 510.7466 1019.4786 1019.5036 -0.0250 0 44 0.0024 1 R.DGAGDVAFIR.E

196. O75635|SPB7_HUMAN Mass: 43163 Score: 43 Queries matched: 2 emPAI: 0.09 Serpin B7 OS=Homo sapiens GN=SERPINB7 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8333 502.2350 1002.4554 1002.5094 -0.0540 0 43 0.0026 1 K.ADLSGIASGGR.L 8334

197. P01023|A2MG_HUMAN Mass: 164614 Score: 43 Queries matched: 8 emPAI: 0.05 Alpha-2-macroglobulin OS=Homo sapiens GN=A2M PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1689 403.7069 805.3993 805.3970 0.0022 0 8 11 4 K.GPTQEFK.K 2435 414.7308 827.4470 827.4501 -0.0031 0 17 1.3 1 K.SDIAPVAR.L 5550 443.7161 885.4176 885.4345 -0.0168 0 36 0.017 1 K.YGAATFTR.T 8447 503.7347 1005.4549 1005.4628 -0.0079 0 16 1.3 1 K.FQVDNNNR.L 10592 552.2952 1102.5758 1102.5982 -0.0224 0 36 0.017 1 R.SSGSLLNNAIK.G

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12672 614.8098 1227.6051 1227.6142 -0.0091 1 1 51 4 K.MLERSNHVSR.T 13026 628.3611 1254.7076 1254.6357 0.0719 0 3 22 3 K.AIGYLNTGYQR.Q 15102 539.9213 1616.7422 1616.8410 -0.0988 0 0 36 4 R.TEVSSNHVLIYLDK.V

198. P51153|RAB13_HUMAN Mass: 22988 Score: 43 Queries matched: 3 emPAI: 0.17 Ras-related protein Rab-13 OS=Homo sapiens GN=RAB13 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2475 415.2110 828.4073 828.4018 0.0056 0 27 0.14 1 R.FFETSAK.S 9935 536.3107 1070.6069 1070.6336 -0.0267 0 43 0.0026 1 K.LLLIGDSGVGK.T 13555 651.8243 1301.6340 1301.6364 -0.0024 0 1 37 10 K.LQVWDTAGQER.F

199. P62820|RAB1A_HUMAN Mass: 22891 Score: 43 Queries matched: 5 emPAI: 0.17 Ras-related protein Rab-1A OS=Homo sapiens GN=RAB1A PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7998 495.7500 989.4855 989.4818 0.0037 0 9 8.2 1 R.TITSSYYR.G 7999 9935 536.3107 1070.6069 1070.6336 -0.0267 0 43 0.0026 1 K.LLLIGDSGVGK.S 12534 609.7964 1217.5783 1217.5823 -0.0040 1 4 21 4 K.RMGPGATAGGAEK.S 12538

200. Q9P1U1|ARP3B_HUMAN Mass: 48090 Score: 43 Queries matched: 4 emPAI: 0.08 Actin-related protein 3B OS=Homo sapiens GN=ACTR3B PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2039 408.2268 814.4390 814.4297 0.0093 0 2 45 10 K.VVDQAQR.R 7135 474.2314 946.4482 946.4720 -0.0237 0 43 0.003 1 R.LSEELSGGR.I 8344 502.2677 1002.5209 1002.4593 0.0616 0 2 39 10 R.HNPVFGVMS.- 12663 613.3031 1224.5916 1224.6503 -0.0587 1 7 10 4 K.KFVIDVGYER.F

201. P01857|IGHG1_HUMAN Mass: 36596 Score: 43 Queries matched: 2 emPAI: 0.10 Ig gamma-1 chain C region OS=Homo sapiens GN=IGHG1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2699 419.7533 837.4921 837.4960 -0.0039 0 14 1.8 1 K.ALPAPIEK.T 12071 593.8184 1185.6222 1185.6394 -0.0172 0 43 0.0028 1 K.GPSVFPLAPSSK.S

202. P99999|CYC_HUMAN Mass: 11855 Score: 43 Queries matched: 3 emPAI: 0.33 Cytochrome c OS=Homo sapiens GN=CYCS PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1699 403.7350 805.4555 805.4698 -0.0142 1 22 0.44 1 K.KYIPGTK.M 2097 412.2296 822.4446 822.4673 -0.0227 0 14 2.1 1 K.M IFVGIK.K 14540 714.8213 1427.6280 1427.6681 -0.0401 0 43 0.0024 1 K.TGQAPGYSYTAANK.N

203. Q9P2D7|DYH1_HUMAN Mass: 497704 Score: 42 Queries matched: 189 emPAI: 0.01 Dynein heavy chain 1, axonemal OS=Homo sapiens GN=DNAH1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3658 422.2043 842.3941 842.3592 0.0349 0 2 41 2 R.YQTMER.I 4893 435.7638 869.5129 869.5083 0.0047 0 26 0.12 1 R.VVQANALR.K 4701 4704 4708 4728 4737 4742 4745 4747 4750 4751 4 6689 465.2502 928.4858 928.5341 -0.0483 1 42 0.0036 1 K.IPSEKLSR.I 6716 10213 540.7645 1079.5145 1079.5910 -0.0764 0 (0) 48 9 R.AMQRPPPGVK.L 10537 548.7607 1095.5069 1095.5859 -0.0790 0 7 9.5 3 R.AMQRPPPGVK.L 11599 578.2245 1154.4344 1154.6230 -0.1886 1 8 5.6 9 K.MTIEPPRGVR.A 11602 578.3101 1154.6057 1154.7023 -0.0966 1 4 17 2 R.LVGLEERIVK.V 11838 586.2954 1170.5763 1170.6179 -0.0416 1 (3) 26 6 K.M TIEPPRGVR.A 14145 684.2899 1366.5653 1366.6663 -0.1010 1 4 14 5 R.DFLRSM ENAIR.F 14146 456.5443 1366.6111 1366.7568 -0.1457 1 0 39 1 K.GIPERLVGLEER.I 15028 516.5943 1546.7611 1546.7773 -0.0162 1 2 27 2 R.M SQNLLRQADLDK.F

204. Q15582|BGH3_HUMAN Mass: 75261 Score: 42 Queries matched: 6 emPAI: 0.05 Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens GN=TGFBI PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2061 409.2342 816.4537 816.4593 -0.0055 0 12 4 1 R.VLTDELK.H 2699 419.7533 837.4921 837.4821 0.0100 1 4 19 2 R.ALPPRER.S 4313 430.2401 858.4657 858.4923 -0.0266 1 7 15 4 R.SRLLGDAK.E 6689 465.2502 928.4858 928.4978 -0.0120 0 42 0.0036 1 K.IPSETLNR.I 7845 492.2706 982.5267 982.5447 -0.0180 0 8 7.4 10 R.ILGDPEALR.D 7867

205. P61224|RAP1B_HUMAN Mass: 21040 Score: 42 Queries matched: 2 emPAI: 0.18 Ras-related protein Rap-1b OS=Homo sapiens GN=RAP1B PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7929 493.2941 984.5736 984.5968 -0.0232 0 42 0.0032 1 K.LVVLGSGGVGK.S 1229

Proteins matching the same set of peptides: P62834|RAP1A_HUMAN Mass: 21316 Score: 42 Queries matched: 2 Ras-related protein Rap-1A OS=Homo sapiens GN=RAP1A PE=1 SV=1

206. P60866|RS20_HUMAN Mass: 13478 Score: 42 Queries matched: 2 emPAI: 0.29 40S ribosomal protein S20 OS=Homo sapiens GN=RPS20 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3709 423.7110 845.4075 845.4429 -0.0354 0 30 0.085 1 K.VCADLIR.G 12912 416.5533 1246.6381 1246.6670 -0.0289 0 42 0.0032 1 K.TPVEPEVAIHR.I

207. O14818|PSA7_HUMAN Mass: 28041 Score: 42 Queries matched: 12 emPAI: 0.29 Proteasome subunit alpha type-7 OS=Homo sapiens GN=PSMA7 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8567 508.7541 1015.4937 1015.5410 -0.0474 1 12 4.4 4 K.LQDERTVR.K 8566 8568 8569 8571 8572 8573 8576 8578 10255 542.7956 1083.5766 1083.5811 -0.0045 0 33 0.026 1 K.ILNPEEIEK.Y

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10581 550.7959 1099.5772 1099.6237 -0.0465 0 35 0.017 1 K.ALLEVVQSGGK.N 10882 559.3149 1116.6152 1116.6073 0.0079 1 2 38 1 K.NIELAVM RR.D

208. P60900|PSA6_HUMAN Mass: 27838 Score: 42 Queries matched: 1 emPAI: 0.14 Proteasome subunit alpha type-6 OS=Homo sapiens GN=PSMA6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13391 643.3590 1284.7035 1284.7150 -0.0115 0 42 0.0029 1 K.AINQGGLTSVAVR.G

209. Q5TFQ8|SIRBL_HUMAN Mass: 43674 Score: 42 Queries matched: 2 emPAI: 0.09 Signal-regulatory protein beta-1 isoform 3 OS=Homo sapiens GN=SIRPB1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7484 482.2696 962.5246 962.5284 -0.0038 0 42 0.0039 1 R.VTTVSDLTK.R 7763 488.7101 975.4056 975.4985 -0.0929 0 8 10 4 K.SGAGTELSVR.A

210. P01876|IGHA1_HUMAN Mass: 38486 Score: 42 Queries matched: 4 emPAI: 0.10 Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6817 466.2596 930.5047 930.5386 -0.0339 0 14 2.7 1 K.TPLTATLSK.S 6819 1090 6992 470.7353 939.4560 939.4774 -0.0214 0 42 0.0033 1 K.SAVQGPPER.D

211. P25398|RS12_HUMAN Mass: 14905 Score: 42 Queries matched: 2 emPAI: 0.26 40S ribosomal protein S12 OS=Homo sapiens GN=RPS12 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9895 533.7801 1065.5456 1065.5931 -0.0475 0 42 0.0034 1 K.TALIHDGLAR.G 10644 553.7638 1105.5131 1105.5624 -0.0493 0 9 7.3 6 K.VVGCSCVVVK.D

212. P12955|PEPD_HUMAN Mass: 55311 Score: 42 Queries matched: 2 emPAI: 0.07 Xaa-Pro dipeptidase OS=Homo sapiens GN=PEPD PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1586 400.2182 798.4218 798.4236 -0.0018 0 42 0.0038 1 R.IDEPGLR.S 6551 460.7511 919.4877 919.5127 -0.0250 0 8 8.8 1 K.AVYEAVLR.S

213. P49773|HINT1_HUMAN Mass: 13907 Score: 42 Queries matched: 1 emPAI: 0.28 Histidine triad nucleotide-binding protein 1 OS=Homo sapiens GN=HINT1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6213 454.2145 906.4144 906.4447 -0.0303 0 42 0.0042 1 K.IIFEDDR.C

214. O00626|CCL22_HUMAN Mass: 10802 Score: 42 Queries matched: 4 emPAI: 0.37 C-C motif chemokine 22 OS=Homo sapiens GN=CCL22 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2062 409.2449 816.4753 816.4970 -0.0217 1 18 1 1 R.YRLPLR.V 7133 473.7631 945.5116 945.5317 -0.0201 1 11 4.5 9 K.MILNKLSQ.- 7132 10587 552.2495 1102.4844 1102.5077 -0.0233 1 42 0.0042 1 R.DKEICADPR.V

215. Q9H3K6|BOLA2_HUMAN Mass: 10281 Score: 41 Queries matched: 1 emPAI: 0.39 BolA-like protein 2 OS=Homo sapiens GN=BOLA2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10294 544.2740 1086.5334 1086.5458 -0.0124 0 41 0.0048 1 K.TLTPDQWAR.E

216. Q9HC38|GLOD4_HUMAN Mass: 35170 Score: 41 Queries matched: 23 emPAI: 0.11 Glyoxalase domain-containing protein 4 OS=Homo sapiens GN=GLOD4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7227 475.7340 949.4534 949.4691 -0.0157 0 41 0.0045 1 R.IAFSCPQK.E 9996 537.2749 1072.5352 1072.6128 -0.0777 0 16 1.4 1 K.VTLAVSDLQK.S 1382 9950 9955 9966 9967 9968 9975 9980 9982 9984

217. Q15121|PEA15_HUMAN Mass: 15088 Score: 41 Queries matched: 2 emPAI: 0.26 Astrocytic phosphoprotein PEA-15 OS=Homo sapiens GN=PEA15 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11972 589.7577 1177.5009 1177.5350 -0.0341 0 41 0.0048 1 K.ISEEDELDTK.L 15166 419.7804 1675.0927 1674.9192 0.1735 1 3 3.4 1 R.QPSEEEIIKLAPPPK.K

218. P30086|PEBP1_HUMAN Mass: 21158 Score: 40 Queries matched: 6 emPAI: 0.18 Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens GN=PEBP1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5540 443.2644 884.5142 884.5331 -0.0189 0 22 0.31 1 K.VLTPTQVK.N 5504 5524 5539 6916 469.2409 936.4672 936.4916 -0.0244 0 37 0.0098 1 K.LYEQLSGK.- 6917

219. P22061|PIMT_HUMAN Mass: 24806 Score: 40 Queries matched: 5 emPAI: 0.15 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7036 471.7616 941.5085 941.5294 -0.0209 0 40 0.0054 1 R.VQLVVGDGR.M 9660 530.7717 1059.5288 1059.5197 0.0091 0 6 16 7 K.DDPTLLSSGR.V 9649 9657 9681

220. P50990|TCPQ_HUMAN Mass: 60153 Score: 40 Queries matched: 4 emPAI: 0.06 T-complex protein 1 subunit theta OS=Homo sapiens GN=CCT8 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 810 443.2458 884.4770 884.5080 -0.0310 0 11 9.4 2 K.TVGATALPR.L 7816 489.7362 977.4579 977.5004 -0.0426 0 3 26 8 K.APGFAQMLK.E 9833 533.2458 1064.4770 1064.5139 -0.0369 0 40 0.0053 1 R.AVDDGVNTFK.V 12913 624.7853 1247.5560 1247.5968 -0.0408 0 3 23 2 K.VADMALHYANK.Y

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221. P05089|ARGI1_HUMAN Mass: 34884 Score: 40 Queries matched: 2 emPAI: 0.11 Arginase-1 OS=Homo sapiens GN=ARG1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10596 552.3164 1102.6183 1102.6386 -0.0203 0 23 0.28 1 R.TIGIIGAPFSK.G 10825 557.2994 1112.5842 1112.5826 0.0016 0 40 0.0052 1 R.GGVEEGPTVLR.K

222. Q8WVV4|POF1B_HUMAN Mass: 69508 Score: 40 Queries matched: 10 emPAI: 0.05 Protein POF1B OS=Homo sapiens GN=POF1B PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6438 457.2601 912.5056 912.4011 0.1045 0 6 15 1 R.TYSGPMNK.V 1022 6359 6389 1034 1036 8582 509.2565 1016.4985 1016.5039 -0.0054 0 1 49 3 R.SQLNQYHK.D 11505 575.2959 1148.5772 1148.6554 -0.0782 0 5 15 6 R.LVLSTFSNIR.E 12109 597.3249 1192.6353 1192.6452 -0.0099 0 26 0.11 1 K.LTTYPQTTIR.K 12897 623.3212 1244.6278 1244.6513 -0.0236 0 40 0.0054 1 K.VVQALDPFNSR.E

223. P28062|PSB8_HUMAN Mass: 30677 Score: 40 Queries matched: 8 emPAI: 0.12 Proteasome subunit beta type-8 OS=Homo sapiens GN=PSMB8 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9917 536.2493 1070.4841 1070.5543 -0.0701 0 14 2.2 3 M.ALLDVCGAPR.G 9908 9910 9911 9915 9916 9918 10534 548.2812 1094.5478 1094.5720 -0.0242 0 40 0.0051 1 R.ASAGSYISALR.V

224. P15090|FABP4_HUMAN Mass: 14824 Score: 40 Queries matched: 1 emPAI: 0.26 Fatty acid-binding protein, adipocyte OS=Homo sapiens GN=FABP4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6907 468.2298 934.4450 934.4872 -0.0423 0 40 0.0071 1 K.EVGVGFATR.K

225. P17900|SAP3_HUMAN Mass: 21281 Score: 39 Queries matched: 4 emPAI: 0.39 Ganglioside GM2 activator OS=Homo sapiens GN=GM2A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2047 408.2439 814.4733 814.4800 -0.0067 0 22 0.39 1 K.VDLVLEK.E 2043 5718 447.7267 893.4387 893.4494 -0.0107 0 23 0.25 1 K.EGTYSLPK.S 8455 503.7643 1005.5140 1005.5342 -0.0202 0 43 0.0026 1 R.IESVLSSSGK.R

226. P02792|FRIL_HUMAN Mass: 20064 Score: 39 Queries matched: 2 emPAI: 0.19 Ferritin light chain OS=Homo sapiens GN=FTL PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2641 417.7353 833.4561 833.4647 -0.0086 0 39 0.0085 1 R.ALFQDIK.K 2642

227. P0C0S5|H2AZ_HUMAN Mass: 13545 Score: 39 Queries matched: 4 emPAI: 0.66 Histone H2A.Z OS=Homo sapiens GN=H2AFZ PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3811 425.7552 849.4959 849.5184 -0.0225 0 28 0.11 1 R.HLQLAIR.G 7101 472.7537 943.4928 943.5240 -0.0311 0 37 0.014 1 R.AGLQFPVGR.I 7100 7105

Proteins matching the same set of peptides: P0C0S8|H2A1_HUMAN Mass: 14083 Score: 39 Queries matched: 4 Histone H2A type 1 OS=Homo sapiens GN=HIST1H2AG PE=1 SV=2 Q6FI13|H2A2A_HUMAN Mass: 14087 Score: 39 Queries matched: 4 Histone H2A type 2-A OS=Homo sapiens GN=HIST2H2AA3 PE=1 SV=3 Q7L7L0|H2A3_HUMAN Mass: 14113 Score: 39 Queries matched: 4 Histone H2A type 3 OS=Homo sapiens GN=HIST3H2A PE=1 SV=3 Q9BTM1|H2AJ_HUMAN Mass: 14011 Score: 39 Queries matched: 4 Histone H2A.J OS=Homo sapiens GN=H2AFJ PE=1 SV=1 Q71UI9|H2AV_HUMAN Mass: 13501 Score: 39 Queries matched: 4 Histone H2A.V OS=Homo sapiens GN=H2AFV PE=1 SV=3 Q96KK5|H2A1H_HUMAN Mass: 13898 Score: 39 Queries matched: 4 Histone H2A type 1-H OS=Homo sapiens GN=HIST1H2AH PE=1 SV=3 Q96QV6|H2A1A_HUMAN Mass: 14225 Score: 39 Queries matched: 4 Histone H2A type 1-A OS=Homo sapiens GN=HIST1H2AA PE=1 SV=3 P04908|H2A1B_HUMAN Mass: 14127 Score: 39 Queries matched: 4 Histone H2A type 1-B/E OS=Homo sapiens GN=HIST1H2AB PE=1 SV=2 P16104|H2AX_HUMAN Mass: 15135 Score: 39 Queries matched: 4 Histone H2A.x OS=Homo sapiens GN=H2AFX PE=1 SV=2 Q16777|H2A2C_HUMAN Mass: 13980 Score: 39 Queries matched: 4 Histone H2A type 2-C OS=Homo sapiens GN=HIST2H2AC PE=1 SV=4 P20671|H2A1D_HUMAN Mass: 14099 Score: 39 Queries matched: 4 Histone H2A type 1-D OS=Homo sapiens GN=HIST1H2AD PE=1 SV=2 Q93077|H2A1C_HUMAN Mass: 14097 Score: 39 Queries matched: 4 Histone H2A type 1-C OS=Homo sapiens GN=HIST1H2AC PE=1 SV=3 Q99878|H2A1J_HUMAN Mass: 13928 Score: 39 Queries matched: 4 Histone H2A type 1-J OS=Homo sapiens GN=HIST1H2AJ PE=1 SV=3

228. P30041|PRDX6_HUMAN Mass: 25133 Score: 39 Queries matched: 10 emPAI: 0.33 Peroxiredoxin-6 OS=Homo sapiens GN=PRDX6 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6174 453.7247 905.4349 905.4607 -0.0258 0 41 0.0055 1 R.NFDEILR.V 1040 458.2325 914.4504 914.4862 -0.0358 0 2 1.1e+002 7 R.VATPVDWK.D 1284 504.2613 1006.5080 1006.5488 -0.0408 0 22 1.3 1 R.VVFVFGPDK.K 9067 519.2574 1036.5003 1036.5342 -0.0339 1 10 5.5 4 K.YLRYTPQP.- 1343 9064 9069 9072 9073 1345

229. P38606|VATA_HUMAN Mass: 68660 Score: 38 Queries matched: 4 emPAI: 0.11 V-type proton ATPase catalytic subunit A OS=Homo sapiens GN=ATP6V1A PE=1 SV=2

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5503 443.2246 884.4345 884.4392 -0.0046 0 14 2.2 1 R.LASFYER.A 5502 6122 451.7471 901.4796 901.4981 -0.0185 0 30 0.077 1 R.GVNVSALSR.D 7480 481.7739 961.5333 961.5444 -0.0111 0 35 0.018 1 K.TVISQSLSK.Y

230. Q96PE2|ARHGH_HUMAN Mass: 223645 Score: 38 Queries matched: 52 emPAI: 0.02 Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5476 442.7546 883.4947 883.5127 -0.0180 0 32 0.032 1 K.LADILSPR.L 5454 5455 5456 5457 5458 5459 5460 5461 5462 5463 5 10928 561.2386 1120.4626 1120.5149 -0.0523 1 2 36 6 R.DGGFEPEKSR.Q 11496 574.7610 1147.5075 1147.6601 -0.1526 0 19 0.71 2 K.VGALLVQSFSK.D 13905 670.8210 1339.6275 1339.7361 -0.1085 1 0 42 6 K.LLERWSGGPGLR.E 13941 671.3331 1340.6517 1340.6468 0.0048 0 10 5.2 5 R.TLM QGYMQPLK.Q 14499 708.8146 1415.6147 1415.7117 -0.0970 1 20 0.45 3 K.GASQATNRENIQK.A 14724 492.5775 1474.7107 1474.6630 0.0478 0 3 22 7 R.EAGHFWDPQNFK.S 14721

231. P62906|RL10A_HUMAN Mass: 24987 Score: 38 Queries matched: 4 emPAI: 0.15 60S ribosomal protein L10a OS=Homo sapiens GN=RPL10A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2002 406.2466 810.4787 810.4963 -0.0176 0 28 0.076 1 R.ILGPGLNK.A 2004 7517 483.7344 965.4543 965.4818 -0.0275 0 38 0.0077 1 R.DTLYEAVR.E 8626 509.7914 1017.5682 1017.5706 -0.0024 1 1 49 2 K.VDEVKSTIK.F

232. P14324|FPPS_HUMAN Mass: 48758 Score: 38 Queries matched: 3 emPAI: 0.08 Farnesyl pyrophosphate synthetase OS=Homo sapiens GN=FDPS PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6837 466.7360 931.4573 931.4359 0.0214 0 2 35 8 K.QDADSLQR.A 8335 502.2540 1002.4934 1002.4982 -0.0047 0 38 0.0098 1 K.IGTDIQDNK.C 8333

233. Q14315|FLNC_HUMAN Mass: 293407 Score: 38 Queries matched: 25 emPAI: 0.03 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2479 415.2366 828.4586 828.4705 -0.0119 0 18 1 1 K.AIVDGNLK.L 291 5392 440.7433 879.4720 879.4484 0.0237 1 0 55 6 R.M KESITR.R 1283 504.2573 1006.5000 1006.5196 -0.0196 0 21 1.6 1 K.IQQNTFTR.W 9561 527.2446 1052.4746 1052.4775 -0.0029 0 40 0.0051 1 K.NDNDTFTVK.Y 10096 538.2531 1074.4916 1074.6073 -0.1158 1 11 4.9 4 R.VKVYGPGVEK.T 10083 10084 10087 10088 10089 10091 10092 10093 13714 657.8217 1313.6289 1313.6285 0.0003 0 6 11 5 R.APSGNEEPCLLK.R 14431 704.3359 1406.6573 1406.7266 -0.0694 1 7 7.9 1 R.VNVGEGSHPERVK.V

234. Q8WZ42|TITIN_HUMAN Mass: 3843119 Score: 37 Queries matched: 183 emPAI: 0.00 Titin OS=Homo sapiens GN=TTN PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1569 790.5872 789.5799 789.4232 0.1567 1 4 26 6 K.DVTAKEK.E 1566 1572 1574 1618 401.2387 800.4629 800.4756 -0.0127 1 6 17 8 K.KGDQILK.Q 1683 403.6963 805.3781 805.4446 -0.0665 0 22 0.46 2 K.TAFVNVR.V 1682 1689 1900 405.2206 808.4267 808.4443 -0.0176 0 6 13 7 K.GTIYSLR.I 1874 2144 412.7369 823.4592 823.4552 0.0040 0 3 23 8 R.APTPSPVR.S 2316 413.2289 824.4432 824.4756 -0.0324 0 8 7.1 5 R.LHVETVK.I 2496 415.7213 829.4280 829.5385 -0.1105 1 12 4.4 5 K.IRISITK.R 2649 418.7396 835.4645 835.4010 0.0635 1 3 34 8 R.WTKCNK.K 2777 421.2162 840.4179 840.4817 -0.0638 1 0 47 1 R.VNRDPIK.A 431 421.7485 841.4824 841.4406 0.0418 1 3 29 3 R.RSPTPER.T 3148 421.7489 841.4833 841.4657 0.0176 0 1 42 8 K.IAGSPEIR.V 3913 426.7133 851.4120 851.4753 -0.0633 0 7 9.3 5 K.TTATFIAK.V 3998 427.2432 852.4718 852.4341 0.0377 1 7 9.3 3 R.FSKTENK.I 4065 428.2541 854.4937 854.4974 -0.0037 1 1 34 4 K.VPEVQKR.V 4042 4077 4088 558 4279 429.7224 857.4303 857.3589 0.0714 0 4 27 5 K.TYTCDAK.D 4289 4291 572 430.2358 858.4570 858.4559 0.0011 0 3 1.1e+002 2 K.QGIDLASR.A 612 432.3116 862.6086 862.4912 0.1174 0 5 97 1 K.KPEAPPPK.V 593 616 617 5154 436.2501 870.4857 870.5109 -0.0252 1 16 1.4 1 K.VPMKPKR.V 5213 437.2394 872.4643 872.5120 -0.0477 0 7 14 7 R.NTILWVK.E 5214 437.2409 872.4673 872.5443 -0.0771 1 5 21 8 K.IKTTLAAR.I 5216 437.2509 872.4871 872.5079 -0.0208 1 6 20 7 K.ELIQSRK.Y 5246 437.7414 873.4681 873.4556 0.0126 0 14 3.3 3 K.AEGILTDR.A 5244 5248 5250 5378 440.7191 879.4237 879.4126 0.0110 0 11 5.1 9 K.AEAEWFK.E 5363 5366 5368 5374 5375 5376 5380 5388 5699 446.7273 891.4401 891.4524 -0.0123 0 4 23 6 K.MSGYPLPK.I 5703 446.7398 891.4651 891.5025 -0.0374 1 0 63 4 K.VATSKTSAK.L 5884 449.2142 896.4139 896.5331 -0.1192 0 4 20 1 K.KPEVTPVK.V 5877 6077 450.7551 899.4957 899.5328 -0.0371 0 9 7.6 2 K.STEPILIK.D 6111 451.7441 901.4736 901.5233 -0.0497 0 4 31 8 R.VTLVDVTR.N 6336 457.2050 912.3955 912.5280 -0.1325 0 2 34 8 R.ITIENVPK.K 6470 458.2412 914.4679 914.4974 -0.0295 0 10 6.2 6 R.QLPPSFAR.Q 6478 6479 6554 461.7238 921.4331 921.5171 -0.0840 0 22 0.33 1 K.ITGYIVEK.K 6580 461.7449 921.4753 921.4556 0.0197 0 9 6.4 8 K.KPAYDGGSK.I 6559 6577 6578 6595 462.7210 923.4274 923.4746 -0.0472 1 4 18 5 K.TVTTKCSK.T 6856 467.2547 932.4948 932.5291 -0.0343 1 2 41 9 K.DRTTLTVK.D 6900 467.7561 933.4976 933.4338 0.0638 0 4 24 2 K.CLEGQTAR.F 1125 472.2551 942.4956 942.5247 -0.0290 1 2 1e+002 1 R.VAAVNEKGR.S 7135 474.2314 946.4482 946.5335 -0.0853 1 37 0.011 2 R.ISEEITKK.Q 7199 474.7151 947.4155 947.5076 -0.0921 0 6 15 3 R.SVFPELTR.T 7200 7203 474.7497 947.4848 947.4746 0.0102 0 10 6.3 4 R.VIAENMAGK.S 7210 7208 474.7548 947.4950 947.5440 -0.0490 0 15 1.8 5 K.IIGYVVER.R 7205 7206 7207 7209 7211 7214 474.7947 947.5748 947.4825 0.0923 1 2 38 5 K.VSWAKDSR.E 7430 480.2663 958.5180 958.6215 -0.1035 1 4 23 6 R.LKFLTPLK.D 7497 482.7342 963.4538 963.4695 -0.0157 0 8 9.1 6 K.CNIVTTEK.T 7498 482.7343 963.4540 963.5753 -0.1213 1 6 13 9 K.QFTVTKLK.E

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7544 485.2672 968.5199 968.6131 -0.0932 1 8 8.1 4 R.LIGELRLR.V 7543 7545 7560 486.2382 970.4618 970.4066 0.0552 0 3 26 3 K.YGISDECK.S 7690 487.7762 973.5378 973.5193 0.0185 1 4 28 1 K.DGKAITQGGK.Y 7669 7670 7820 490.2159 978.4172 978.5750 -0.1578 1 2 30 10 K.KEYTIVVK.V 7929 493.2941 984.5736 984.4256 0.1480 0 5 17 7 R.CSITMTEK.S 8107 498.2850 994.5554 994.5560 -0.0006 1 2 28 4 R.HVQKQIDK.T 8134 500.2146 998.4146 998.5873 -0.1727 1 2 30 8 R.KVGIDNVVR.K 1266 501.7508 1001.4871 1001.5658 -0.0787 1 6 14 5 R.NNVTLKWK.K 1267 501.7759 1001.5372 1001.5393 -0.0022 0 6 17 3 K.NPEVTTITK.D 8338 502.2641 1002.5136 1002.5247 -0.0111 1 2 38 7 K.ITWAKDNR.E 8416 503.2657 1004.5168 1004.6018 -0.0851 1 13 3 2 R.YKIVLQNK.H 8431 503.3592 1004.7038 1004.5080 0.1958 0 1 32 2 K.NPPFFDIR.L 8444 503.7309 1005.4472 1005.4727 -0.0255 0 9 6.6 2 K.TSQASEEVR.T 8445 8448 8453 8451 503.7391 1005.4636 1005.4879 -0.0243 1 9 6.7 3 R.QSGDSAWKK.S 8446 8449 8511 507.7357 1013.4567 1013.5757 -0.1190 0 19 0.73 2 K.DLTIQPSLK.L 8510 8512 8513 8514 8515 8516 8517 8519 8580 508.7772 1015.5398 1015.4934 0.0463 0 5 21 9 K.GSSELVPGDR.C 8576 1319 515.2978 1028.5810 1028.4961 0.0849 0 12 11 2 K.VLDSPGPCGK.L 1308 1313 1316 8902 1320 8908 516.2601 1030.5057 1030.5407 -0.0350 0 1 49 8 K.VTNDNLLSR.K 9573 528.7576 1055.5007 1055.5764 -0.0757 0 3 26 3 K.GKPAPSVSWK.K 9574 9603 529.7355 1057.4564 1057.5655 -0.1091 0 9 8.7 1 K.APEIIDVSSK.A 9595 9600 9605 9606 9608 9610 9612 9613 9616 9819 532.8154 1063.6163 1063.6026 0.0137 1 8 8.1 3 K.IVGYSIEKR.Q 10139 538.7168 1075.4190 1075.5873 -0.1683 1 5 16 4 K.DGKLLTSSQK.H 10144 538.7857 1075.5568 1075.6614 -0.1046 1 6 14 8 R.ILKPQGRHK.T 10207 540.3254 1078.6362 1078.6022 0.0340 1 3 26 2 K.EIKPSSKYK.I 10249 542.7350 1083.4553 1083.4906 -0.0353 0 7 10 3 R.EDSGLYICK.A 10409 545.7160 1089.4174 1089.5051 -0.0876 0 5 15 5 K.GDQELSNTAR.L 10458 546.7464 1091.4782 1091.5836 -0.1054 0 1 42 8 K.STHHVVSGLR.E 10586 552.2420 1102.4695 1102.5805 -0.1110 1 6 17 7 R.DGVPLKATMR.F 10909 560.3313 1118.6480 1118.5325 0.1156 1 11 5.1 1 R.MSPARMSPAR.M 10894 10916 11412 571.2399 1140.4653 1140.5775 -0.1122 1 0 40 6 R.KRPEEEEPK.V 11476 572.8212 1143.6278 1143.6724 -0.0446 1 7 12 1 K.TVTIRAGASLR.L 11490 573.7890 1145.5634 1145.6656 -0.1021 1 10 4.9 10 K.KLSDISTVVGK.E 11492 11679 581.2971 1160.5797 1160.6223 -0.0426 1 21 0.44 2 K.IEGDLRAMLK.K 11678 11680 11681 11686 12092 595.3021 1188.5897 1188.5887 0.0010 0 1 40 10 K.QLVGTNEWSR.C 12235 598.8157 1195.6168 1195.6422 -0.0254 1 6 14 7 R.SPTPERTRPR.S 27 403.1592 1206.4557 1206.6067 -0.1510 1 6 69 2 K.VTWKLEEMR.L 36 12629 611.7940 1221.5735 1221.7081 -0.1346 1 3 26 4 R.VVAEEKVPVPR.K 12676 615.2906 1228.5665 1228.5935 -0.0270 0 2 30 10 R.VEAEPAEVTER.Q 12687 615.7951 1229.5756 1229.7278 -0.1522 1 2 30 5 K.TLILRAGVTMR.L 12819 619.8541 1237.6937 1237.6013 0.0924 0 1 39 2 R.TYIPVMSGENK.L 12861 620.3494 1238.6843 1238.5779 0.1064 0 0 43 3 K.DEYLISQSER.C 12911 624.3255 1246.6364 1246.6227 0.0137 1 5 17 3 K.EMTPREEIVK.K 12985 626.7863 1251.5581 1251.5918 -0.0336 1 10 4.7 3 K.IRDQYEMPGK.L 12980 12981 12982 12983 12984 12986 13083 630.7835 1259.5525 1259.6609 -0.1084 0 3 26 2 K.EVTLDDISQIK.A 13416 646.7806 1291.5466 1291.7136 -0.1670 1 4 20 3 K.EAPPAKVPEVQK.R 13419 647.3155 1292.6163 1292.7088 -0.0925 1 11 4 4 R.RDTGQYVLTLK.N 13417 13466 432.2309 1293.6708 1293.7366 -0.0658 1 1 42 1 K.IMGYIIEKIAK.G 638 433.5424 1297.6054 1297.7030 -0.0977 1 5 16 2 R.VTKDPIHPYTK.F 775 437.2593 1308.7560 1308.7626 -0.0067 1 9 20 1 R.VAARNAVGVSLPR.E 13854 446.5640 1336.6703 1336.6623 0.0080 1 0 41 3 R.KDTWGVVSSGSSK.T 14143 683.3573 1364.7000 1364.6493 0.0507 0 2 32 6 R.DVTAEDSASIMVK.A 14639 722.3142 1442.6138 1442.6282 -0.0144 1 1 33 8 K.EMARFECELSR.E

235. P30153|2AAA_HUMAN Mass: 66065 Score: 37 Queries matched: 3 emPAI: 0.06 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens GN=PPP2R1A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9374 523.2966 1044.5787 1044.5022 0.0765 0 1 44 1 R.M AGDPVANVR.F 10422 545.7680 1089.5215 1089.5203 0.0012 1 3 32 7 R.QAAEDKSWR.V 11665 580.7815 1159.5485 1159.5721 -0.0236 0 37 0.01 1 K.LTQDQDVDVK.Y

236. Q14847|LASP1_HUMAN Mass: 30097 Score: 37 Queries matched: 3 emPAI: 0.27 LIM and SH3 domain protein 1 OS=Homo sapiens GN=LASP1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3787 425.2307 848.4468 848.4644 -0.0175 0 19 0.72 1 K.IVYPTEK.V 3782 9427 523.7684 1045.5223 1045.5404 -0.0181 0 38 0.0096 1 K.TQDQISNIK.Y

237. P47755|CAZA2_HUMAN Mass: 33157 Score: 37 Queries matched: 2 emPAI: 0.11 F-actin-capping protein subunit alpha-2 OS=Homo sapiens GN=CAPZA2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5308 438.7367 875.4588 875.4712 -0.0124 0 37 0.015 1 R.TSVETALR.A 5689 446.2102 890.4057 890.4399 -0.0341 1 3 32 4 R.WRSEWK.F

238. P55854|SUMO3_HUMAN Mass: 11687 Score: 37 Queries matched: 2 emPAI: 0.34 Small ubiquitin-related modifier 3 OS=Homo sapiens GN=SUMO3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12744 617.8084 1233.6022 1233.6354 -0.0332 0 37 0.011 1 K.VAGQDGSVVQFK.I 13295 639.3147 1276.6149 1276.6333 -0.0184 1 7 11 1 -.MSEEKPKEGVK.T

239. P04040|CATA_HUMAN Mass: 59947 Score: 37 Queries matched: 3 emPAI: 0.06 Catalase OS=Homo sapiens GN=CAT PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7479 481.7652 961.5158 961.5233 -0.0074 0 28 0.11 1 K.DAQIFIQK.K 7534 484.7309 967.4472 967.5815 -0.1343 0 2 31 10 K.LNVITVGPR.G 7666 487.7357 973.4569 973.4828 -0.0259 0 37 0.014 1 K.NLSVEDAAR.L

240. Q86WR0|CCD25_HUMAN Mass: 24634 Score: 37 Queries matched: 84 emPAI: 0.15

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Coiled-coil domain-containing protein 25 OS=Homo sapiens GN=CCDC25 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2058 408.7471 815.4795 815.5116 -0.0321 1 9 10 5 K.IVTVEKK.V 9291 523.2820 1044.5493 1044.5716 -0.0223 0 35 0.019 1 K.LSSAHVYLR.L 9207 9208 9209 9210 9211 9212 9213 9214 9215 9216

241. Q9UPR0|PLCL2_HUMAN Mass: 127268 Score: 36 Queries matched: 41 emPAI: 0.03 Inactive phospholipase C-like protein 2 OS=Homo sapiens GN=PLCL2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3839 426.2346 850.4546 850.4153 0.0393 1 11 4.2 1 R.ALKM GCR.S 6091 451.2342 900.4539 900.5280 -0.0741 0 17 1.5 4 R.SVIDIINK.Y 6087 6592 462.7009 923.3872 923.4205 -0.0332 1 3 26 6 K.KVCQDM K.Q 6730 465.7486 929.4826 929.4315 0.0510 0 5 22 9 K.AGVGEGGGGGGR.L 6976 470.7188 939.4229 939.5138 -0.0908 0 36 0.012 2 R.ESKPGGLPR.R 6972 6973 6974 6975 6977 6978 6979 6981 6982 6983 11900 589.3233 1176.6321 1176.6060 0.0261 0 3 28 1 K.ELSELVSICK.S 11927 11935 12115 597.7696 1193.5247 1193.5564 -0.0317 1 14 1.8 2 K.YEPSKEGQEK.G 12113 12116 12117 12119 12120 12123 12124 12127 13269 633.8593 1265.7040 1265.6074 0.0966 0 4 20 1 R.ENMQNAVVSFK.E 13291 636.8358 1271.6571 1271.6478 0.0092 1 15 1.6 4 K.QQKVMVQHMK.K 13520 650.3808 1298.7471 1298.6691 0.0780 1 0 42 9 K.GALKAGVGEGGGGGGR.L 14082 453.2150 1356.6232 1356.6595 -0.0363 1 2 32 1 K.TVSFSSM PTEKK.I 14084 679.3421 1356.6696 1356.6595 0.0101 1 1 40 10 K.KTVSFSSMPTEK.K

242. Q6ZR08|DYH12_HUMAN Mass: 359792 Score: 36 Queries matched: 21 emPAI: 0.01 Dynein heavy chain 12, axonemal OS=Homo sapiens GN=DNAH12 PE=2 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3336 421.7514 841.4883 841.4698 0.0185 0 2 32 5 K.VPEIWAK.R 4292 429.7301 857.4457 857.4606 -0.0149 0 7 16 2 K.NLNELQK.I 4288 4291 4303 8419 503.2879 1004.5613 1004.5542 0.0071 1 17 1.1 6 K.YPELDKLK.V 10578 550.2689 1098.5233 1098.5921 -0.0688 0 6 12 5 K.EALEGVKPEK.L 10802 555.7381 1109.4617 1109.4488 0.0129 0 33 0.022 1 K.WECPFDEK.G 10803 11186 566.2501 1130.4857 1130.5390 -0.0533 0 14 2.3 5 K.MTNEPPTGLR.L 11176 11178 11185 11191 11195 11599 578.2245 1154.4344 1154.5390 -0.1046 0 7 6.3 10 R.MQQYVTDVR.Q 13044 628.3678 1254.7210 1254.6503 0.0707 1 0 44 3 R.DAVANKHTMIR.L 13752 663.8401 1325.6655 1325.7191 -0.0535 0 12 3.3 2 K.QSVENLLPTPTK.S 13751 13934 671.3170 1340.6194 1340.7663 -0.1469 1 0 48 7 K.AAIAAEKEALNLK.L 14323 465.2343 1392.6811 1392.6635 0.0176 0 3 21 3 K.GLVYDYMYELK.N

243. P53675|CLH2_HUMAN Mass: 189020 Score: 36 Queries matched: 13 emPAI: 0.02 Clathrin heavy chain 2 OS=Homo sapiens GN=CLTCL1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5499 443.2043 884.3940 884.4028 -0.0088 0 22 0.31 1 R.AYEFAER.C 5501 6483 458.7332 915.4518 915.5025 -0.0507 0 34 0.027 1 K.LDALESLR.K 1043 6482 6484 6487 6488 1132 472.2692 942.5239 942.5321 -0.0082 0 5 57 1 -.MAQILPVR.F 7075 9197 522.7885 1043.5625 1043.5975 -0.0349 1 2 38 3 K.LDALESLRK.Q 9624 530.2560 1058.4975 1058.5720 -0.0745 1 1 45 5 K.TGQIKEVER.I 11185 566.2492 1130.4839 1130.4774 0.0065 0 7 12 6 K.DAMQHAAESR.D

244. P30740|ILEU_HUMAN Mass: 42829 Score: 36 Queries matched: 2 emPAI: 0.09 Leukocyte elastase inhibitor OS=Homo sapiens GN=SERPINB1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8454 503.7496 1005.4845 1005.4879 -0.0034 0 36 0.015 1 K.EATTNAPFR.L 10583 551.7688 1101.5231 1101.5917 -0.0686 0 6 13 4 K.IEEQLTLEK.L

245. P28066|PSA5_HUMAN Mass: 26565 Score: 35 Queries matched: 1 emPAI: 0.14 Proteasome subunit alpha type-5 OS=Homo sapiens GN=PSMA5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9786 532.2501 1062.4857 1062.5094 -0.0237 0 35 0.016 1 R.GVNTFSPEGR.L

246. Q9Y4G6|TLN2_HUMAN Mass: 273781 Score: 35 Queries matched: 17 emPAI: 0.01 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5156 436.2509 870.4872 870.4923 -0.0051 0 16 1.5 1 R.LQAAGNAVK.R 5684 445.7284 889.4423 889.4327 0.0096 0 3 35 8 R.ELIECAR.A 6728 465.7456 929.4766 929.5043 -0.0276 1 14 2.7 3 K.RASDNLVR.A 6727 6729 6730 6732 6735 6736 8479 506.2436 1010.4727 1010.6236 -0.1509 1 9 6.5 4 K.KLEQLKPR.A 8926 516.3001 1030.5857 1030.6022 -0.0165 0 8 9.2 1 K.SIAAATSALVK.S 9139 521.2762 1040.5378 1040.6091 -0.0713 1 17 1 2 R.QQRLAQVAK.A 1348 11485 573.2935 1144.5725 1144.6088 -0.0363 0 35 0.016 1 K.EVANSTANLVK.T 13506 650.3744 1298.7342 1298.6540 0.0802 0 1 36 1 K.TMLESSSYLIR.T 13722 658.8152 1315.6158 1315.6732 -0.0574 0 11 3.9 4 R.QEDVIATANLSR.K 13847 669.3070 1336.5995 1336.6921 -0.0927 0 1 37 9 K.AEHGSVALPAVMR.S

247. P59665|DEF1_HUMAN Mass: 10536 Score: 35 Queries matched: 1 emPAI: 0.38 Neutrophil defensin 1 OS=Homo sapiens GN=DEFA1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7932 493.7356 985.4566 985.5015 -0.0449 0 35 0.018 1 R.IPACIAGER.R

Proteins matching the same set of peptides: P59666|DEF3_HUMAN Mass: 10580 Score: 35 Queries matched: 1 Neutrophil defensin 3 OS=Homo sapiens GN=DEFA3 PE=1 SV=1

248. P61916|NPC2_HUMAN Mass: 16902 Score: 35 Queries matched: 1 emPAI: 0.23 Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8565 508.7413 1015.4680 1015.5121 -0.0440 0 35 0.02 1 K.SGINCPIQK.D

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249. O43776|SYNC_HUMAN Mass: 63758 Score: 35 Queries matched: 4 emPAI: 0.06 Asparaginyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=NARS PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3722 424.2101 846.4057 846.4308 -0.0250 1 7 12 7 R.AEQSRTR.R 6554 461.7238 921.4331 921.4378 -0.0047 0 22 0.33 1 R.DVCLYPR.F 8108 498.7467 995.4789 995.4924 -0.0135 0 35 0.017 1 K.NDPSLPEPK.C 14125 683.3040 1364.5934 1364.5999 -0.0065 1 2 32 4 R.HMMIRGENMSK.I

250. P62993|GRB2_HUMAN Mass: 25304 Score: 35 Queries matched: 3 emPAI: 0.15 Growth factor receptor-bound protein 2 OS=Homo sapiens GN=GRB2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6539 459.7530 917.4913 917.5083 -0.0169 0 35 0.022 1 R.NQQIFLR.D 10453 546.2601 1090.5057 1090.5441 -0.0384 1 7 11 3 K.AEEMLSKQR.H 10454

251. Q6NSJ5|LRC8E_HUMAN Mass: 91417 Score: 35 Queries matched: 2 emPAI: 0.04 Leucine-rich repeat-containing protein 8E OS=Homo sapiens GN=LRRC8E PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2641 417.7353 833.4561 833.5011 -0.0450 1 19 0.8 3 K.ALFEKVK.K 7762 488.2947 974.5749 974.5583 0.0166 1 35 0.023 1 R.QTVLKVCK.F

252. Q92889|XPF_HUMAN Mass: 105333 Score: 34 Queries matched: 5 emPAI: 0.04 DNA repair endonuclease XPF OS=Homo sapiens GN=ERCC4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5355 440.6953 879.3760 879.4338 -0.0577 1 34 0.02 1 K.EKEAFEK.L 5708 446.7450 891.4754 891.4160 0.0594 0 1 53 5 K.AEEVWMK.F 10082 537.7983 1073.5821 1073.5353 0.0468 0 3 27 10 R.DETNLDLVR.G 11603 578.8051 1155.5956 1155.6499 -0.0543 1 10 5.3 9 K.KELVLESNPK.W 12456 606.3116 1210.6087 1210.5805 0.0282 1 7 9.1 6 K.AEEVWMKFR.K

253. P40926|MDHM_HUMAN Mass: 35937 Score: 34 Queries matched: 4 emPAI: 0.22 Malate dehydrogenase, mitochondrial OS=Homo sapiens GN=MDH2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2089 411.7174 821.4203 821.4283 -0.0080 1 18 0.94 1 K.KGEDFVK.T 8049 496.7524 991.4902 991.5338 -0.0436 0 26 0.17 1 R.ANTFVAELK.G 10040 537.2926 1072.5707 1072.5764 -0.0057 0 35 0.019 1 R.IQEAGTEVVK.A 10046

254. O00408|PDE2A_HUMAN Mass: 107360 Score: 34 Queries matched: 7 emPAI: 0.03 cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens GN=PDE2A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4737 435.7509 869.4872 869.5083 -0.0211 0 5 15 3 R.VQVLQQR.G 4831 6600 463.2043 924.3940 924.4925 -0.0985 1 34 0.017 1 R.FCLMVKK.G 6599 7256 478.2435 954.4725 954.5498 -0.0773 0 1 36 7 K.EALSAVLPR.V 12032 590.8039 1179.5933 1179.6836 -0.0903 1 2 33 6 R.VQVLQQRGPR.E 14815 496.2221 1485.6445 1485.5833 0.0613 0 7 8.5 2 K.AMGNRPMEMMDR.E

255. P58107|EPIPL_HUMAN Mass: 555149 Score: 34 Queries matched: 8 emPAI: 0.02 Epiplakin OS=Homo sapiens GN=EPPK1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1486 600.3194 599.3122 599.3755 -0.0634 0 4 24 2 K.VGLVGR.E 6094 451.2570 900.4994 900.5029 -0.0034 0 3 36 5 R.LAAVDVSAR.A 6538 459.7499 917.4852 917.4971 -0.0119 0 31 0.046 1 R.VPVDVAYR.R 8363 502.7530 1003.4915 1003.4822 0.0093 0 21 0.46 1 R.VIEETEER.L 9647 530.7617 1059.5089 1059.5084 0.0005 0 30 0.07 1 R.VLADPSDDTK.G 11379 570.3302 1138.6459 1138.5804 0.0654 1 3 22 9 R.LSIYEARCK.G 1464 580.7491 1159.4837 1159.4604 0.0233 0 1 41 3 R.GYFDEEMNR.V 13721 439.5345 1315.5817 1315.5615 0.0202 1 1 36 4 R.RGYFDEEMNR.V

256. P59998|ARPC4_HUMAN Mass: 19768 Score: 34 Queries matched: 4 emPAI: 0.43 Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens GN=ARPC4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7203 474.7497 947.4848 947.5328 -0.0479 0 22 0.38 1 R.IVAEEFLK.N 7210 8472 505.2639 1008.5133 1008.5392 -0.0260 0 32 0.03 1 R.AENFFILR.R 12072 593.8283 1185.6420 1185.6717 -0.0297 0 27 0.11 1 K.VLIEGSINSVR.V

257. Q92598|HS105_HUMAN Mass: 97716 Score: 34 Queries matched: 6 emPAI: 0.04 Heat shock protein 105 kDa OS=Homo sapiens GN=HSPH1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5437 442.2393 882.4640 882.4447 0.0193 0 4 17 9 K.VDQPPEAK.K 8778 513.2191 1024.4236 1024.4648 -0.0412 0 6 11 6 K.MFEELGQR.L 10893 560.3010 1118.5874 1118.6084 -0.0210 0 34 0.024 1 R.FVVQNVSAQK.D 11586 576.3091 1150.6036 1150.5726 0.0310 1 8 8.6 8 K.MIMQDKLEK.E 13819 446.2011 1335.5814 1335.6823 -0.1008 1 8 6.6 1 R.AFNDPFIQKEK.E 15396 434.5571 2601.2987 2601.2529 0.0459 0 3 10 1 K.VM YMGEEHLFSVEQITAMLLTK.L

258. Q14240|IF4A2_HUMAN Mass: 46601 Score: 34 Queries matched: 5 emPAI: 0.08 Eukaryotic initiation factor 4A-II OS=Homo sapiens GN=EIF4A2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7384 479.2703 956.5261 956.5291 -0.0030 0 34 0.026 1 R.ELAQQIQK.V 1377 533.2752 1064.5359 1064.5437 -0.0078 1 1 1.6e+002 4 R.DVIMREFR.S 9889 533.7520 1065.4894 1065.5389 -0.0495 1 10 5.7 4 R.VFDMLNRR.Y 9886 9891

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Proteins matching the same set of peptides: P60842|IF4A1_HUMAN Mass: 46353 Score: 34 Queries matched: 5 Eukaryotic initiation factor 4A-I OS=Homo sapiens GN=EIF4A1 PE=1 SV=1

259. Q6ZN18|AEBP2_HUMAN Mass: 54946 Score: 34 Queries matched: 6 emPAI: 0.07 Zinc finger protein AEBP2 OS=Homo sapiens GN=AEBP2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1610 401.2294 800.4443 800.3916 0.0527 0 34 0.032 2 K.EGLEEPK.G 1614 1617 1618 1623 5294 438.2419 874.4693 874.4396 0.0297 1 10 6.3 1 K.AKEESPSK.A

260. P21281|VATB2_HUMAN Mass: 56807 Score: 33 Queries matched: 2 emPAI: 0.07 V-type proton ATPase subunit B, brain isoform OS=Homo sapiens GN=ATP6V1B2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5213 437.2394 872.4643 872.4716 -0.0073 0 25 0.24 1 R.EQALAVSR.N 10424 545.7811 1089.5476 1089.5666 -0.0190 0 33 0.027 1 R.SGQVLEVSGSK.A

261. O43707|ACTN4_HUMAN Mass: 105245 Score: 33 Queries matched: 6 emPAI: 0.04 Alpha-actinin-4 OS=Homo sapiens GN=ACTN4 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2006 406.2532 810.4918 810.4963 -0.0045 0 26 0.13 1 K.VQQLVPK.R 2003 2316 413.2289 824.4432 824.4392 0.0040 0 33 0.022 1 R.LDHLAEK.F 2305 11227 567.2995 1132.5845 1132.5659 0.0186 1 1 46 9 K.AETAANRICK.V 13503 650.3702 1298.7258 1298.6619 0.0640 0 6 13 1 R.HRPELIEYDK.L

262. P28838|AMPL_HUMAN Mass: 56530 Score: 33 Queries matched: 4 emPAI: 0.07 Cytosol aminopeptidase OS=Homo sapiens GN=LAP3 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1372 532.3869 531.3796 531.3129 0.0667 1 3 65 3 K.AGKTR.T 3784 425.2251 848.4356 848.4643 -0.0287 0 33 0.03 1 R.FAEIIEK.N 3785 8343 502.2676 1002.5207 1002.5393 -0.0186 1 3 30 4 R.KGMTGRPTR.T

263. P06454|PTMA_HUMAN Mass: 12196 Score: 33 Queries matched: 1 emPAI: 0.32 Prothymosin alpha OS=Homo sapiens GN=PTMA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15040 522.5413 1564.6021 1564.6376 -0.0355 1 33 0.013 1 R.AAEDDEDDDVDTKK.Q

264. Q13835|PKP1_HUMAN Mass: 84119 Score: 33 Queries matched: 2 emPAI: 0.04 Plakophilin-1 OS=Homo sapiens GN=PKP1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5716 447.2342 892.4538 892.4402 0.0135 0 9 7.6 3 R.QLEYNAR.N 12073 594.3135 1186.6125 1186.6306 -0.0181 0 33 0.025 1 R.LLQSGNSDVVR.S

265. Q86VP6|CAND1_HUMAN Mass: 137999 Score: 33 Queries matched: 3 emPAI: 0.03 Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens GN=CAND1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3814 426.2198 850.4250 850.4436 -0.0186 0 33 0.025 1 R.IGEYLEK.I 11384 570.7660 1139.5175 1139.5571 -0.0396 0 2 28 8 K.HTVDDGLDIR.K 14652 724.3750 1446.7354 1446.7541 -0.0187 1 4 19 3 K.ELIREVEMGPFK.H

266. Q8N335|GPD1L_HUMAN Mass: 39021 Score: 33 Queries matched: 3 emPAI: 0.10 Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens GN=GPD1L PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4330 431.2196 860.4246 860.4491 -0.0245 0 33 0.035 1 K.TIEELEK.E 4328 4329

267. Q09666|AHNK_HUMAN Mass: 629213 Score: 33 Queries matched: 58 emPAI: 0.01 Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens GN=AHNAK PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 264 413.2370 824.4595 824.4102 0.0493 0 2 75 1 K.FSMPSLK.G 2377 3664 422.2295 842.4445 842.4498 -0.0053 0 11 5.3 7 K.ADLGVSGPK.V 4367 433.7449 865.4752 865.4732 0.0021 1 3 30 7 K.VTFPKMK.I 6087 451.2264 900.4382 900.4553 -0.0171 0 31 0.05 1 K.ADIDVSGPK.V 6091 451.2342 900.4539 900.4553 -0.0013 0 32 0.041 1 K.ADVDISGPK.I 6238 455.2529 908.4911 908.4967 -0.0056 0 1 42 10 K.AEAPLPSPK.L 8186 501.2444 1000.4743 1000.5302 -0.0558 0 2 36 8 K.VGGSGVNVNAK.G 8300 501.7766 1001.5386 1001.5580 -0.0194 0 8 11 4 K.LQVTMPGIK.V 8514 507.7366 1013.4586 1013.5393 -0.0808 0 0 52 9 K.VQTPEVDVK.G 9576 528.7840 1055.5535 1055.5723 -0.0188 1 8 8.8 6 R.EGQTPKAGLR.V 10771 555.2304 1108.4462 1108.5877 -0.1415 0 10 4.1 6 R.VSAPEVSVGHK.G 10770 10774 10781 1422 11147 564.7509 1127.4872 1127.6186 -0.1314 1 26 0.14 2 K.IKGDVDVSAPK.L 11139 11140 11141 11142 11143 11144 11145 111 11535 575.8280 1149.6415 1149.5554 0.0861 0 0 48 3 K.DIDISSPEFK.I 12040 591.2852 1180.5558 1180.5984 -0.0426 1 1 35 5 K.MPKFSMPSLK.G 12044 591.7917 1181.5687 1181.5160 0.0527 0 8 6.9 9 R.LSSSSSNDSGNK.V 12697 616.2878 1230.5610 1230.5889 -0.0279 1 1 41 8 K.MPEMHFKAPK.I 379 421.1920 1260.5540 1260.6272 -0.0731 0 1 1.3e+002 4 K.MSLPDVDLDLK.G 13103 631.3011 1260.5877 1260.5995 -0.0118 1 5 17 8 K.MPEMHFKTPK.I 13274 634.3256 1266.6366 1266.6820 -0.0454 1 0 43 5 K.GEGPEVDVKLPK.A 13544 651.3186 1300.6226 1300.6155 0.0070 0 1 40 5 K.ISMPDVDLHMK.G 13546 651.3204 1300.6263 1300.6697 -0.0434 1 1 39 6 K.GPDVKLPDMSVK.T 14517 713.3330 1424.6514 1424.6491 0.0022 1 6 13 2 K.SRLSSSSSNDSGNK.V 14518 14522

268. P12532|KCRU_HUMAN Mass: 47406 Score: 33 Queries matched: 5 emPAI: 0.08 Creatine kinase U-type, mitochondrial OS=Homo sapiens GN=CKMT1A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2484 415.7101 829.4057 829.4657 -0.0601 1 5 24 10 R.GLKEVER.L

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4285 429.7270 857.4395 857.3780 0.0615 0 4 31 7 R.HNGYDPR.T 5212 437.1903 872.3660 872.3664 -0.0004 0 33 0.039 1 R.SGYFDER.Y 13284 635.8125 1269.6105 1269.5237 0.0869 0 1 36 9 R.GWEFMWNER.L 13283

269. P61247|RS3A_HUMAN Mass: 30154 Score: 32 Queries matched: 4 emPAI: 0.13 40S ribosomal protein S3a OS=Homo sapiens GN=RPS3A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1488 603.2996 602.2923 602.3752 -0.0828 1 1 1.4e+002 5 R.LTKGGK.K 6545 460.2441 918.4736 918.5175 -0.0439 1 6 16 5 K.KVVDPFSK.K 8128 499.7398 997.4650 997.4395 0.0255 1 2 33 10 R.DKMCSMVK.K 8288 501.7659 1001.5171 1001.5393 -0.0222 0 32 0.037 1 K.LITEDVQGK.N

270. O94788|AL1A2_HUMAN Mass: 57144 Score: 32 Queries matched: 2 emPAI: 0.07 Retinal dehydrogenase 2 OS=Homo sapiens GN=ALDH1A2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2054 408.7366 815.4586 815.4753 -0.0166 0 32 0.044 1 R.VTLELGGK.S 4277 429.2371 856.4596 856.4766 -0.0171 0 23 0.33 1 K.LIQEAAGR.S

271. P00352|AL1A1_HUMAN Mass: 55454 Score: 32 Queries matched: 4 emPAI: 0.07 Retinal dehydrogenase 1 OS=Homo sapiens GN=ALDH1A1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2054 408.7366 815.4586 815.4753 -0.0166 0 32 0.044 1 R.VTLELGGK.S 2292 413.2225 824.4304 824.3334 0.0970 0 5 14 1 R.TM DASER.G 2478 415.2349 828.4553 828.4705 -0.0152 0 7 14 2 K.LADLIER.D 10581 550.7959 1099.5772 1099.5985 -0.0214 1 2 34 4 K.LADLIERDR.L

272. Q5JNZ5|RS26L_HUMAN Mass: 13336 Score: 32 Queries matched: 2 emPAI: 0.30 Putative 40S ribosomal protein S26-like 1 OS=Homo sapiens GN=RPS26P11 PE=5 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1904 405.2247 808.4348 808.3320 0.1028 0 8 7.8 4 R.CTNCVR.C 7037 471.7633 941.5120 941.5294 -0.0174 0 32 0.031 1 R.NIVEAAAVR.D

273. P02545|LMNA_HUMAN Mass: 74380 Score: 32 Queries matched: 3 emPAI: 0.10 Lamin-A/C OS=Homo sapiens GN=LMNA PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 69 404.2119 806.4093 806.4286 -0.0193 1 19 4.6 3 K.VREEFK.E 5612 444.2400 886.4654 886.4760 -0.0106 0 26 0.17 1 R.LVEIDNGK.Q 7588 486.7533 971.4920 971.5036 -0.0116 0 31 0.05 1 R.LSPSPTSQR.S

274. Q11203|SIAT6_HUMAN Mass: 42429 Score: 32 Queries matched: 22 emPAI: 0.09 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase OS=Homo sapiens GN=ST3GAL3 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11174 566.2372 1130.4598 1130.6295 -0.1697 1 32 0.031 2 K.ARVITDLSSGI.- 11175 11176 11177 11178 11179 11180 11181 11183 12087 595.2848 1188.5551 1188.6503 -0.0952 1 9 7.4 1 R.LNSAPVKGFEK.D

275. A4D0S4|LAMB4_HUMAN Mass: 200769 Score: 32 Queries matched: 11 emPAI: 0.02 Laminin subunit beta-4 OS=Homo sapiens GN=LAMB4 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8546 508.2748 1014.5351 1014.5822 -0.0470 1 14 2.7 3 K.AQEAKSIIR.N 10068 537.7664 1073.5182 1073.4989 0.0194 0 10 5.7 2 R.LNEEADGAQK.L 10060 10073 10078 13396 429.8891 1286.6456 1286.6579 -0.0123 1 2 31 2 K.DLRGNVSEIER.I 13395 14499 708.8146 1415.6147 1415.7554 -0.1408 1 32 0.026 1 R.RQIMQLNEQLK.A 14742 738.3814 1474.7482 1474.7991 -0.0509 0 8 6.7 6 R.ANSTITQLTANITK.I 14730 14750

276. P49720|PSB3_HUMAN Mass: 23219 Score: 32 Queries matched: 4 emPAI: 0.16 Proteasome subunit beta type-3 OS=Homo sapiens GN=PSMB3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2646 418.2303 834.4459 834.4058 0.0401 0 5 22 5 K.IFPMGDR.L 2645 5709 446.7451 891.4757 891.5065 -0.0308 0 32 0.041 1 R.LNLYELK.E 14744 738.3837 1474.7529 1474.6618 0.0911 0 5 15 6 M.SIMSYNGGAVMAMK.G

277. O95336|6PGL_HUMAN Mass: 27815 Score: 32 Queries matched: 2 emPAI: 0.14 6-phosphogluconolactonase OS=Homo sapiens GN=PGLS PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10974 561.3004 1120.5862 1120.6128 -0.0267 0 32 0.036 1 R.TVIFVATGEGK.A 10928

278. P30046|DOPD_HUMAN Mass: 12818 Score: 32 Queries matched: 6 emPAI: 0.31 D-dopachrome decarboxylase OS=Homo sapiens GN=DDT PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4668 435.2591 868.5036 868.5130 -0.0095 1 5 15 1 R.VPAGLEKR.L 707 4667 793 441.2708 880.5270 880.4728 0.0542 0 14 5.5 1 K.IGTVMTFL.- 6088 451.2292 900.4439 900.4665 -0.0225 0 32 0.046 1 K.ELALGQDR.I 6094

279. P25786|PSA1_HUMAN Mass: 29822 Score: 32 Queries matched: 16 emPAI: 0.13 Proteasome subunit alpha type-1 OS=Homo sapiens GN=PSMA1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2058 408.7471 815.4795 815.5116 -0.0321 0 32 0.052 1 R.LVSLIGSK.T 2060 2440 414.7446 827.4747 827.3120 0.1628 0 2 42 8 K.ADEPMEH.- 3663 422.2247 842.4348 842.4610 -0.0262 0 24 0.25 1 K.TQIPTQR.Y 3667 825 443.7651 885.5156 885.5284 -0.0127 0 17 1.4 1 K.NVSIGIVGK.D 994 454.2316 906.4485 906.3865 0.0620 0 3 74 2 R.QECLDSR.F 7250 477.2849 952.5553 952.4623 0.0930 0 9 6.2 10 R.LLCNFMR.Q

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10734 554.2610 1106.5074 1106.6924 -0.1850 1 9 7.6 6 K.THAVLVALKR.A 10729 10737 10739 10741 10750 10752 13972 673.3294 1344.6443 1344.6773 -0.0329 0 22 0.32 1 R.ETLPAEQDLTTK.N

280. P55060|XPO2_HUMAN Mass: 111145 Score: 32 Queries matched: 5 emPAI: 0.03 Exportin-2 OS=Homo sapiens GN=CSE1L PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6992 470.7353 939.4560 939.5502 -0.0942 0 6 12 4 R.TGNIPALVR.L 7251 477.3006 952.5867 952.5957 -0.0090 0 32 0.034 2 K.IIIPEIQK.V 7250 859 448.2013 1341.5820 1341.7115 -0.1295 1 10 21 3 K.ADGIKYIM IFR.N 15224 477.0152 1904.0317 1904.0515 -0.0198 1 0 28 1 K.MFGM VLEKIIIPEIQK.V

281. Q9ULV4|COR1C_HUMAN Mass: 53899 Score: 31 Queries matched: 3 emPAI: 0.07 Coronin-1C OS=Homo sapiens GN=CORO1C PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5521 443.2583 884.5020 884.4868 0.0152 0 2 31 1 R.HVFGQAVK.N 5505 12291 599.7384 1197.4623 1197.4720 -0.0097 0 31 0.028 1 K.NDQCYDDIR.V

282. P22304|IDS_HUMAN Mass: 62233 Score: 31 Queries matched: 31 emPAI: 0.06 Iduronate 2-sulfatase OS=Homo sapiens GN=IDS PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1610 401.2294 800.4443 800.4756 -0.0313 1 31 0.056 3 R.EGKNLLK.H 1614 1617 1618 1623 552 428.2576 854.5007 854.4320 0.0687 0 9 16 1 K.IMGYSIR.T 4001 4004 4013 4017 4025 4026 4035 4039 4042 4044 4045

283. P62269|RS18_HUMAN Mass: 17708 Score: 31 Queries matched: 1 emPAI: 0.22 40S ribosomal protein S18 OS=Homo sapiens GN=RPS18 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12905 624.2717 1246.5288 1246.5677 -0.0389 0 31 0.038 1 R.AGELTEDEVER.V

284. P46781|RS9_HUMAN Mass: 22635 Score: 31 Queries matched: 5 emPAI: 0.17 40S ribosomal protein S9 OS=Homo sapiens GN=RPS9 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2496 415.7213 829.4280 829.4545 -0.0266 0 31 0.061 1 R.IGVLDEGK.M 2504 2505 2507 6552 461.2253 920.4360 920.4603 -0.0243 0 16 1.6 1 K.IEDFLER.R

285. Q8NB37|PDDC1_HUMAN Mass: 23796 Score: 31 Queries matched: 1 emPAI: 0.16 Parkinson disease 7 domain-containing protein 1 OS=Homo sapiens GN=PDDC1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7204 474.7506 947.4866 947.5440 -0.0574 1 31 0.048 1 R.LKAYASPAK.L

286. P16949|STMN1_HUMAN Mass: 17292 Score: 31 Queries matched: 4 emPAI: 0.22 Stathmin OS=Homo sapiens GN=STMN1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6252 456.7271 911.4395 911.4712 -0.0317 0 31 0.038 1 K.SHEAEVLK.Q 7120 473.2576 944.5006 944.4927 0.0079 1 12 4.9 9 K.KLEAAEER.R 7608 487.2601 972.5056 972.4988 0.0068 1 12 4.3 10 K.LEAAEERR.K 10079 537.7743 1073.5341 1073.5604 -0.0263 0 27 0.13 1 K.DLSLEEIQK.K

287. Q8NEZ4|MLL3_HUMAN Mass: 548270 Score: 31 Queries matched: 22 emPAI: 0.01 Histone-lysine N-methyltransferase MLL3 OS=Homo sapiens GN=MLL3 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2793 421.2333 840.4521 840.3171 0.1350 0 5 14 2 -.MSSEEDK.S 2799 2800 2807 5312 438.7562 875.4979 875.4422 0.0557 0 6 16 8 K.LSMETPAK.T 5309 5640 444.7310 887.4474 887.4501 -0.0028 0 9 8.5 3 K.SVPTNGWK.C 5707 446.7445 891.4745 891.4371 0.0374 0 (5) 19 4 K.LSMETPAK.T 6145 452.7279 903.4413 903.4297 0.0115 0 31 0.056 1 K.LEEQNGSK.V 6141 6142 6143 6144 6146 6147 6148 1039 457.7756 913.5365 913.5345 0.0021 1 14 2.3 2 K.QLEQIRK.Q 7153 474.2743 946.5341 946.4041 0.1300 0 1 48 3 K.AQCM FFK.D 8361 502.7449 1003.4753 1003.5372 -0.0619 0 0 53 4 K.MVTDGAILGK.L 9823 533.2442 1064.4738 1064.5727 -0.0988 1 9 7.1 7 K.SNVYLARSR.I 9831 11958 589.3344 1176.6543 1176.5856 0.0688 1 4 21 1 R.QMQAM IRQR.S

288. Q01968|OCRL_HUMAN Mass: 105392 Score: 31 Queries matched: 39 emPAI: 0.04 Inositol polyphosphate 5-phosphatase OCRL-1 OS=Homo sapiens GN=OCRL PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6982 470.7230 939.4314 939.5502 -0.1187 0 13 2.3 5 R.QVISQLPR.C 7964 494.2912 986.5679 986.4893 0.0786 1 3 34 2 R.QTPSDRQR.A 10952 561.2849 1120.5552 1120.6968 -0.1416 1 21 0.4 2 R.EGLIKHILAK.R 10946 10950 10953 10954 10959 10966 10967 10970 11650 579.7814 1157.5482 1157.5941 -0.0459 1 29 0.076 1 R.VQGDWIRER.R 11634 11635 11636 11637 11639 11640 11641 11642 1 13103 631.3011 1260.5877 1260.6390 -0.0513 1 5 15 3 K.FIPTYKYDSK.T

289. O14523|C2C2L_HUMAN Mass: 76590 Score: 31 Queries matched: 56 emPAI: 0.05 C2 domain-containing protein 2-like OS=Homo sapiens GN=C2CD2L PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7561 486.2421 970.4696 970.6175 -0.1479 1 4 22 5 R.ELTLKVLR.S 9949 537.2539 1072.4932 1072.5513 -0.0580 1 31 0.055 1 K.LDSPSRSPSK.V 1382 9950 9951 9953 9955 9956 9957 9959 9961 9962 10296 544.3201 1086.6257 1086.5669 0.0588 1 7 14 3 R.IDGKLDSPSR.S

290. Q96KP4|CNDP2_HUMAN Mass: 53187 Score: 31 Queries matched: 3 emPAI: 0.07 Cytosolic non-specific dipeptidase OS=Homo sapiens GN=CNDP2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5173 436.7445 871.4745 871.4763 -0.0018 1 0 63 10 R.LGSDPQKK.T 7939 494.2434 986.4721 986.4709 0.0013 0 31 0.053 1 R.YNYIEGTK.M

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10819 556.8080 1111.6015 1111.5986 0.0030 0 26 0.12 1 K.TGQEIPVNVR.F

291. Q63HK5|TSH3_HUMAN Mass: 119518 Score: 30 Queries matched: 15 emPAI: 0.03 Teashirt homolog 3 OS=Homo sapiens GN=TSHZ3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5622 444.2502 886.4859 886.4760 0.0099 0 4 31 7 K.AVTDEKPK.Q 5777 448.2069 894.3992 894.4117 -0.0125 0 2 34 7 K.MSNSLAEK.A 11474 572.8094 1143.6043 1143.6135 -0.0092 1 30 0.052 1 K.EKAVTDEKPK.Q 11461 11462 11463 11464 11467 11468 11469 11470

Mascot: http://www.matrixscience.com/

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Mascot Search Results

User : Email : Search title : Database : SwissProt 57.12 (513877 sequences; 180750753 residues) Taxonomy : Homo sapiens (human) (20329 sequences) Timestamp : 12 Feb 2010 at 15:08:55 GMT Enzyme : Trypsin Fixed modifications : Carbamidomethyl (C) Variable modifications : Oxidation (M) Mass values : Monoisotopic Protein Mass : Unrestricted Peptide Mass Tolerance : ± 0.2 Da Fragment Mass Tolerance: ± 0.2 Da Max Missed Cleavages : 1 Instrument type : ESI-QUAD-TOF Number of queries : 50298 Protein hits : P13645|K1C10_HUMAN Keratin, type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 P35527|K1C9_HUMAN Keratin, type I cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 P35908|K22E_HUMAN Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 P04264|K2C1_HUMAN Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 P02533|K1C14_HUMAN Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 P08779|K1C16_HUMAN Keratin, type I cytoskeletal 16 OS=Homo sapiens GN=KRT16 PE=1 SV=4 P13647|K2C5_HUMAN Keratin, type II cytoskeletal 5 OS=Homo sapiens GN=KRT5 PE=1 SV=3 Q04695|K1C17_HUMAN Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 P04259|K2C6B_HUMAN Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 P02538|K2C6A_HUMAN Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 P02649|APOE_HUMAN Apolipoprotein E OS=Homo sapiens GN=APOE PE=1 SV=1 P19012|K1C15_HUMAN Keratin, type I cytoskeletal 15 OS=Homo sapiens GN=KRT15 PE=1 SV=2 P02768|ALBU_HUMAN Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 P13646|K1C13_HUMAN Keratin, type I cytoskeletal 13 OS=Homo sapiens GN=KRT13 PE=1 SV=4 Q7Z3Y7|K1C28_HUMAN Keratin, type I cytoskeletal 28 OS=Homo sapiens GN=KRT28 PE=1 SV=1 P61626|LYSC_HUMAN Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 P36222|CH3L1_HUMAN Chitinase-3-like protein 1 OS=Homo sapiens GN=CHI3L1 PE=1 SV=2 P60709|ACTB_HUMAN Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 Q7Z3Y8|K1C27_HUMAN Keratin, type I cytoskeletal 27 OS=Homo sapiens GN=KRT27 PE=1 SV=1 P19013|K2C4_HUMAN Keratin, type II cytoskeletal 4 OS=Homo sapiens GN=KRT4 PE=1 SV=4 Q5D862|FILA2_HUMAN Filaggrin-2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 Q86Y46|K2C73_HUMAN Keratin, type II cytoskeletal 73 OS=Homo sapiens GN=KRT73 PE=1 SV=1 P08670|VIME_HUMAN Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 P81605|DCD_HUMAN Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 Q99456|K1C12_HUMAN Keratin, type I cytoskeletal 12 OS=Homo sapiens GN=KRT12 PE=1 SV=1 P14780|MMP9_HUMAN Matrix metalloproteinase-9 OS=Homo sapiens GN=MMP9 PE=1 SV=3 Q6S8J3|POTEE_HUMAN POTE ankyrin domain family member E OS=Homo sapiens GN=POTEE PE=1 SV=3 P15924|DESP_HUMAN Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 Q14525|KT33B_HUMAN Keratin, type I cuticular Ha3-II OS=Homo sapiens GN=KRT33B PE=1 SV=3 Q15323|K1H1_HUMAN Keratin, type I cuticular Ha1 OS=Homo sapiens GN=KRT31 PE=1 SV=3 O76013|KRT36_HUMAN Keratin, type I cuticular Ha6 OS=Homo sapiens GN=KRT36 PE=1 SV=1 P05783|K1C18_HUMAN Keratin, type I cytoskeletal 18 OS=Homo sapiens GN=KRT18 PE=1 SV=2 P07355|ANXA2_HUMAN Annexin A2 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 Q01546|K22O_HUMAN Keratin, type II cytoskeletal 2 oral OS=Homo sapiens GN=KRT76 PE=1 SV=1 P01023|A2MG_HUMAN Alpha-2-macroglobulin OS=Homo sapiens GN=A2M PE=1 SV=2 P12035|K2C3_HUMAN Keratin, type II cytoskeletal 3 OS=Homo sapiens GN=KRT3 PE=1 SV=2 P63104|1433Z_HUMAN 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 P04075|ALDOA_HUMAN Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2 P60174|TPIS_HUMAN Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=2 A8MT79|ZAGL1_HUMAN Putative zinc-alpha-2-glycoprotein-like 1 OS=Homo sapiens PE=5 SV=2 P12036|NFH_HUMAN Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 P06396|GELS_HUMAN Gelsolin OS=Homo sapiens GN=GSN PE=1 SV=1 P52566|GDIR2_HUMAN Rho GDP-dissociation inhibitor 2 OS=Homo sapiens GN=ARHGDIB PE=1 SV=3 P04406|G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 O00391|QSOX1_HUMAN Sulfhydryl oxidase 1 OS=Homo sapiens GN=QSOX1 PE=1 SV=3 P05090|APOD_HUMAN Apolipoprotein D OS=Homo sapiens GN=APOD PE=1 SV=1 Q9UBR2|CATZ_HUMAN Cathepsin Z OS=Homo sapiens GN=CTSZ PE=1 SV=1 P01876|IGHA1_HUMAN Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 P10451|OSTP_HUMAN Osteopontin OS=Homo sapiens GN=SPP1 PE=1 SV=1 P25774|CATS_HUMAN Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 Q13231|CHIT1_HUMAN Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 P07737|PROF1_HUMAN Profilin-1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 P08238|HS90B_HUMAN Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4 P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 P31025|LCN1_HUMAN Lipocalin-1 OS=Homo sapiens GN=LCN1 PE=1 SV=1 Q8N1N4|K2C78_HUMAN Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=1 SV=2 P62988|UBIQ_HUMAN Ubiquitin OS=Homo sapiens GN=RPS27A PE=1 SV=1 P14618|KPYM_HUMAN Pyruvate kinase isozymes M1/M2 OS=Homo sapiens GN=PKM2 PE=1 SV=4 P17900|SAP3_HUMAN Ganglioside GM2 activator OS=Homo sapiens GN=GM2A PE=1 SV=4 P06733|ENOA_HUMAN Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 Q5VSK2|MRC1L_HUMAN Macrophage mannose receptor 1-like protein 1 OS=Homo sapiens GN=MRC1L1 PE=2 SV=1 P07195|LDHB_HUMAN L-lactate dehydrogenase B chain OS=Homo sapiens GN=LDHB PE=1 SV=2 P05107|ITB2_HUMAN Integrin beta-2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 O43933|PEX1_HUMAN Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 P06703|S10A6_HUMAN Protein S100-A6 OS=Homo sapiens GN=S100A6 PE=1 SV=1 P04083|ANXA1_HUMAN Annexin A1 OS=Homo sapiens GN=ANXA1 PE=1 SV=2 P01591|IGJ_HUMAN Immunoglobulin J chain OS=Homo sapiens GN=IGJ PE=1 SV=4 P00338|LDHA_HUMAN L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 Q6ZMR3|LDH6A_HUMAN L-lactate dehydrogenase A-like 6A OS=Homo sapiens GN=LDHAL6A PE=2 SV=1 Q9H299|SH3L3_HUMAN SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 P02787|TRFE_HUMAN Serotransferrin OS=Homo sapiens GN=TF PE=1 SV=2 Q9NSB2|KRT84_HUMAN Keratin, type II cuticular Hb4 OS=Homo sapiens GN=KRT84 PE=1 SV=1 Q7Z794|K2C1B_HUMAN Keratin, type II cytoskeletal 1b OS=Homo sapiens GN=KRT77 PE=1 SV=2

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P01842|LAC_HUMAN Ig lambda chain C regions OS=Homo sapiens GN=IGLC1 PE=1 SV=1 P61769|B2MG_HUMAN Beta-2-microglobulin OS=Homo sapiens GN=B2M PE=1 SV=1 Q5T749|KPRP_HUMAN Keratinocyte proline-rich protein OS=Homo sapiens GN=KPRP PE=1 SV=1 P09382|LEG1_HUMAN Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 P62942|FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens GN=FKBP1A PE=1 SV=2 P12814|ACTN1_HUMAN Alpha-actinin-1 OS=Homo sapiens GN=ACTN1 PE=1 SV=2 O00299|CLIC1_HUMAN Chloride intracellular channel protein 1 OS=Homo sapiens GN=CLIC1 PE=1 SV=4 P31146|COR1A_HUMAN Coronin-1A OS=Homo sapiens GN=CORO1A PE=1 SV=4 P02751|FINC_HUMAN Fibronectin OS=Homo sapiens GN=FN1 PE=1 SV=3 O00241|SIRB1_HUMAN Signal-regulatory protein beta-1 OS=Homo sapiens GN=SIRPB1 PE=1 SV=4 Q12931|TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens GN=TRAP1 PE=1 SV=3 P61916|NPC2_HUMAN Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 Q8N1A0|KT222_HUMAN Keratin-like protein KRT222 OS=Homo sapiens GN=KRT222 PE=2 SV=1 P18206|VINC_HUMAN Vinculin OS=Homo sapiens GN=VCL PE=1 SV=4 Q86U44|MTA70_HUMAN N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3 PE=1 SV=2 P01833|PIGR_HUMAN Polymeric immunoglobulin receptor OS=Homo sapiens GN=PIGR PE=1 SV=4 Q9BYE4|SPR2G_HUMAN Small proline-rich protein 2G OS=Homo sapiens GN=SPRR2G PE=2 SV=1 P61981|1433G_HUMAN 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 P06753|TPM3_HUMAN Tropomyosin alpha-3 chain OS=Homo sapiens GN=TPM3 PE=1 SV=1 P04040|CATA_HUMAN Catalase OS=Homo sapiens GN=CAT PE=1 SV=3 Q9Y240|CLC11_HUMAN C-type lectin domain family 11 member A OS=Homo sapiens GN=CLEC11A PE=1 SV=1 P09467|F16P1_HUMAN Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=4 P11215|ITAM_HUMAN Integrin alpha-M OS=Homo sapiens GN=ITGAM PE=1 SV=2 P60900|PSA6_HUMAN Proteasome subunit alpha type-6 OS=Homo sapiens GN=PSMA6 PE=1 SV=1 P19971|TYPH_HUMAN Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2 P09960|LKHA4_HUMAN Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 P20742|PZP_HUMAN Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=4 Q5VTE0|EF1A3_HUMAN Putative elongation factor 1-alpha-like 3 OS=Homo sapiens GN=EEF1AL3 PE=5 SV=1 P40925|MDHC_HUMAN Malate dehydrogenase, cytoplasmic OS=Homo sapiens GN=MDH1 PE=1 SV=4 Q8TER0|SNED1_HUMAN Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens GN=SNED1 PE=1 SV=2 Q14974|IMB1_HUMAN Importin subunit beta-1 OS=Homo sapiens GN=KPNB1 PE=1 SV=2 P0C869|PA24B_HUMAN Cytosolic phospholipase A2 beta OS=Homo sapiens GN=PLA2G4B PE=1 SV=1 P14649|MYL6B_HUMAN 6B OS=Homo sapiens GN=MYL6B PE=1 SV=1 P05155|IC1_HUMAN Plasma protease C1 inhibitor OS=Homo sapiens GN=SERPING1 PE=1 SV=2 P01034|CYTC_HUMAN Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1 P31949|S10AB_HUMAN Protein S100-A11 OS=Homo sapiens GN=S100A11 PE=1 SV=2 P35754|GLRX1_HUMAN Glutaredoxin-1 OS=Homo sapiens GN=GLRX PE=1 SV=2 O00175|CCL24_HUMAN C-C motif chemokine 24 OS=Homo sapiens GN=CCL24 PE=1 SV=2 P31947|1433S_HUMAN 14-3-3 protein sigma OS=Homo sapiens GN=SFN PE=1 SV=1 Q15582|BGH3_HUMAN Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens GN=TGFBI PE=1 SV=1 P00918|CAH2_HUMAN Carbonic anhydrase 2 OS=Homo sapiens GN=CA2 PE=1 SV=2 P31946|1433B_HUMAN 14-3-3 protein beta/alpha OS=Homo sapiens GN=YWHAB PE=1 SV=3 P78417|GSTO1_HUMAN Glutathione S-transferase omega-1 OS=Homo sapiens GN=GSTO1 PE=1 SV=2 Q06830|PRDX1_HUMAN Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 P55058|PLTP_HUMAN Phospholipid transfer protein OS=Homo sapiens GN=PLTP PE=1 SV=1 Q99536|VAT1_HUMAN Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens GN=VAT1 PE=1 SV=2 P37837|TALDO_HUMAN Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 Q9Y281|COF2_HUMAN Cofilin-2 OS=Homo sapiens GN=CFL2 PE=1 SV=1 P28065|PSB9_HUMAN Proteasome subunit beta type-9 OS=Homo sapiens GN=PSMB9 PE=1 SV=2 P08758|ANXA5_HUMAN Annexin A5 OS=Homo sapiens GN=ANXA5 PE=1 SV=2 P37802|TAGL2_HUMAN Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 Q15648|MED1_HUMAN Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens GN=MED1 PE=1 SV=4 P18084|ITB5_HUMAN Integrin beta-5 OS=Homo sapiens GN=ITGB5 PE=1 SV=1 P16150|LEUK_HUMAN Leukosialin OS=Homo sapiens GN=SPN PE=1 SV=1 Q08EQ4|TMSL1_HUMAN Thymosin beta-4-like protein 1 OS=Homo sapiens GN=TMSL1 PE=2 SV=1 P52790|HXK3_HUMAN Hexokinase-3 OS=Homo sapiens GN=HK3 PE=1 SV=2 O76054|S14L2_HUMAN SEC14-like protein 2 OS=Homo sapiens GN=SEC14L2 PE=1 SV=1 P20702|ITAX_HUMAN Integrin alpha-X OS=Homo sapiens GN=ITGAX PE=1 SV=3 Q9C075|K1C23_HUMAN Keratin, type I cytoskeletal 23 OS=Homo sapiens GN=KRT23 PE=1 SV=2 O00626|CCL22_HUMAN C-C motif chemokine 22 OS=Homo sapiens GN=CCL22 PE=1 SV=1 P80748|LV302_HUMAN Ig lambda chain V-III region LOI OS=Homo sapiens PE=1 SV=1 Q7Z6K2|TPISL_HUMAN Putative triosephosphate isomerase-like protein LOC286016 OS=Homo sapiens PE=1 SV=2 P02788|TRFL_HUMAN Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 Q9ULI0|ATD2B_HUMAN ATPase family AAA domain-containing protein 2B OS=Homo sapiens GN=ATAD2B PE=1 SV=2 P07951|TPM2_HUMAN Tropomyosin beta chain OS=Homo sapiens GN=TPM2 PE=1 SV=1 Q6P3X3|TTC27_HUMAN Tetratricopeptide repeat protein 27 OS=Homo sapiens GN=TTC27 PE=1 SV=1 P15259|PGAM2_HUMAN Phosphoglycerate mutase 2 OS=Homo sapiens GN=PGAM2 PE=1 SV=3 P07339|CATD_HUMAN Cathepsin D OS=Homo sapiens GN=CTSD PE=1 SV=1 Q6PKX4|DOK6_HUMAN Docking protein 6 OS=Homo sapiens GN=DOK6 PE=1 SV=1 O43439|MTG8R_HUMAN Protein CBFA2T2 OS=Homo sapiens GN=CBFA2T2 PE=1 SV=1 P31629|ZEP2_HUMAN Transcription factor HIVEP2 OS=Homo sapiens GN=HIVEP2 PE=1 SV=2 Q9NUQ3|TXLNG_HUMAN Gamma-taxilin OS=Homo sapiens GN=TXLNG PE=1 SV=2 Q03989|ARI5A_HUMAN AT-rich interactive domain-containing protein 5A OS=Homo sapiens GN=ARID5A PE=2 SV=2 Q8TF21|ANR24_HUMAN Ankyrin repeat domain-containing protein 24 OS=Homo sapiens GN=ANKRD24 PE=2 SV=2 Q13733|AT1A4_HUMAN Sodium/potassium-transporting ATPase subunit alpha-4 OS=Homo sapiens GN=ATP1A4 PE=1 SV=3 Q5VVW2|GARL3_HUMAN GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Homo sapiens GN=GARNL3 PE=1 SV=2 Q16769|QPCT_HUMAN Glutaminyl-peptide cyclotransferase OS=Homo sapiens GN=QPCT PE=1 SV=1 P80075|CCL8_HUMAN C-C motif chemokine 8 OS=Homo sapiens GN=CCL8 PE=1 SV=2 Q6NSJ5|LRC8E_HUMAN Leucine-rich repeat-containing protein 8E OS=Homo sapiens GN=LRRC8E PE=2 SV=1 Q9NY47|CA2D2_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-2 OS=Homo sapiens GN=CACNA2D2 PE=1 S P26447|S10A4_HUMAN Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1 P28066|PSA5_HUMAN Proteasome subunit alpha type-5 OS=Homo sapiens GN=PSMA5 PE=1 SV=3 Q63ZY3|KANK2_HUMAN KN motif and ankyrin repeat domain-containing protein 2 OS=Homo sapiens GN=KANK2 PE=1 SV=1 O76009|KT33A_HUMAN Keratin, type I cuticular Ha3-I OS=Homo sapiens GN=KRT33A PE=1 SV=2 Q86XW9|TXND6_HUMAN Thioredoxin domain-containing protein 6 OS=Homo sapiens GN=TXNDC6 PE=1 SV=1 Q8NES3|LFNG_HUMAN Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe OS=Homo sapiens GN=LFNG PE=1 SV=2 O75347|TBCA_HUMAN Tubulin-specific chaperone A OS=Homo sapiens GN=TBCA PE=1 SV=3 P05109|S10A8_HUMAN Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 P22528|SPR1B_HUMAN Cornifin-B OS=Homo sapiens GN=SPRR1B PE=1 SV=2

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P29401|TKT_HUMAN Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 P26038|MOES_HUMAN Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 P21333|FLNA_HUMAN Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 Q9P219|DAPLE_HUMAN Protein Daple OS=Homo sapiens GN=CCDC88C PE=1 SV=2 P13639|EF2_HUMAN Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4

Select Summary Report

Format As Select Summary (protein hits) Help Significance threshold p< 0.05 Max. number of hits AUTO Standard scoring %$#"! MudPIT scoring %$#"! Ions score or expect cut-off 0 Show sub-sets 0 Show pop-ups %$#"! Suppress pop-ups %$#"! Sort unassigned Decreasing Score Require bold red 

1. P13645|K1C10_HUMAN Mass: 59020 Score: 11767 Queries matched: 604 emPAI: 3.61 Keratin, type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 R.LAADDFR.L 121 16513 16514 16515 16516 16517 16518 16519 12 16720 405.2167 808.4188 808.4330 -0.0143 0 48 0.00086 1 R.LASYLDK.V 186 16697 16698 16699 16701 16702 16703 16704 16 19915 424.2265 846.4385 846.4447 -0.0062 0 50 0.00066 1 K.SEITELR.R 19897 2252 19898 19899 2253 19900 19901 19902 19 25541 497.2372 992.4598 992.4927 -0.0329 0 51 0.00046 1 K.YENEVALR.Q 25535 25536 25537 25538 25539 25540 25542 25543 25613 498.2532 994.4918 994.5123 -0.0206 1 27 0.095 1 K.IKEWYEK.H 6505 25602 25603 25605 25606 25607 25608 25609 2 6746 502.2699 1002.5253 1002.5458 -0.0204 1 23 1.1 1 K.SEITELRR.N 25908 25910 25911 25912 25913 25915 25916 25917 7383 516.2997 1030.5848 1030.5910 -0.0062 0 51 0.0015 1 R.VLDELTLTK.A 7359 26662 7360 7361 7364 26665 26666 7365 736 27931 532.7949 1063.5752 1063.6026 -0.0274 1 59 6.6e-005 1 R.LASYLDKVR.A 27929 27930 27932 27933 27934 27935 27936 2793 28990 545.7648 1089.5150 1089.5237 -0.0087 0 59 7.7e-005 1 K.VTMQNLNDR.L 28950 28951 28952 28954 28955 28957 28958 2895 29453 553.7507 1105.4868 1105.5186 -0.0318 0 (44) 0.0025 1 K.VTMQNLNDR.L 29449 29450 29451 29452 29455 29456 29457 9434 29646 555.2396 1108.4647 1108.4825 -0.0178 0 41 0.0038 1 K.DAEAWFNEK.S 29633 9467 9468 29639 9470 29642 29643 29644 2 31354 583.2849 1164.5553 1164.5775 -0.0222 0 75 1.5e-006 1 R.LENEIQTYR.S 31336 31338 31339 10708 31342 31343 31344 3134 31969 594.3414 1186.6682 1186.6921 -0.0239 1 29 0.064 1 R.RVLDELTLTK.A 31968 32349 601.3042 1200.5939 1200.6098 -0.0160 0 65 1.6e-005 1 R.QSVEADINGLR.R 11551 32348 11552 32352 33293 617.8297 1233.6447 1233.6717 -0.0269 1 61 4.5e-005 1 R.LKYENEVALR.Q 33287 33288 33289 33290 33291 33292 33294 332 33504 619.2807 1236.5468 1236.5775 -0.0307 1 28 0.074 1 R.KDAEAWFNEK.S 34055 631.7939 1261.5733 1261.5899 -0.0165 0 93 2.4e-008 1 R.SLLEGEGSSGGGGR.G 34027 34028 34029 34030 34031 34032 3403 35292 650.7988 1299.5830 1299.5877 -0.0047 1 1 37 2 K.NHEEEMKDLR.N 13794 679.3609 1356.7073 1356.7110 -0.0037 1 18 1.9 1 R.QSVEADINGLRR.V 4664 36612 36614 36615 36731 683.3028 1364.5911 1364.6320 -0.0409 0 86 1e-007 1 R.SQYEQLAEQNR.K 36724 36725 36726 36727 36728 36729 36730 3 37010 691.3126 1380.6106 1380.6408 -0.0303 0 108 7.4e-010 1 R.ALEESNYELEGK.I 13968 36984 36985 36986 36987 36988 36989 1 37150 695.8296 1389.6447 1389.6736 -0.0288 0 105 1.4e-009 1 K.QSLEASLAETEGR.Y 37146 37147 37149 37151 37152 37153 37154 37889 717.8756 1433.7366 1433.7626 -0.0260 1 61 3.6e-005 1 K.IRLENEIQTYR.S 37887 37888 37891 37894 38865 747.3649 1492.7152 1492.7270 -0.0118 1 63 2.2e-005 1 R.SQYEQLAEQNRK.D 38835 38836 38837 38838 38840 38841 38842 3 39436 775.3301 1548.6457 1548.6700 -0.0243 0 114 1.5e-010 1 R.SGGGGGGGGCGGGGGVSSLR.I 39434 39435 39437 39439 39440 3944 40739 854.3723 1706.7301 1706.7649 -0.0348 0 162 1.9e-015 1 K.GSLGGGFSSGGFSGGSFSR.G 40728 40729 40730 40731 40732 40733 42075 1041.9630 2081.9115 2081.9575 -0.0461 0 106 6.9e-010 1 R.AETECQNTEYQQLLDIK.I 14020 42675 738.0327 2211.0762 2211.0906 -0.0144 1 23 0.13 1 K.SKELTTEIDNNIEQISSYK.S 47040 1018.2127 3051.6162 3051.6200 -0.0038 1 31 0.012 1 K.TIDDLKNQILNLTTDNANILLQIDNAR.L

2. P35527|K1C9_HUMAN Mass: 62255 Score: 11424 Queries matched: 476 emPAI: 3.02 Keratin, type I cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16720 405.2167 808.4188 808.4330 -0.0143 0 48 0.00086 1 R.LASYLDK.V 186 16697 16698 16699 16701 16702 16703 16704 16 4449 449.2002 896.3858 896.4062 -0.0204 0 38 0.019 1 R.MTLDDFR.I 23165 4448 23167 4450 23168 23170 4451 23171 445 23721 457.2602 912.5057 912.4011 0.1046 0 (25) 0.16 1 R.MTLDDFR.I 4820 4821 4822 4823 4826 4827 4828 4831 4832 4833 24987 484.2244 966.4342 966.4447 -0.0105 0 21 0.42 1 K.IQDWYDK.K 27741 530.7839 1059.5531 1059.5560 -0.0029 0 60 5.8e-005 1 K.TLLDIDNTR.M 27717 27718 27720 27721 27722 8257 8258 27723 27956 533.2369 1064.4593 1064.4920 -0.0327 0 (53) 0.00026 1 K.STMQELNSR.L 27952 27954 27959 27961 27962 27968 27969 2797 8383 533.7406 1065.4667 1065.4913 -0.0246 0 (13) 2.5 1 K.FEMEQNLR.Q 28047 28280 537.7535 1073.4924 1073.5142 -0.0218 0 35 0.019 1 R.QFSSSYLSR.S 8605 28279 8607 28281 28283 28284 28297 28461 541.2257 1080.4369 1080.4870 -0.0500 0 71 3.8e-006 1 K.STMQELNSR.L 28458 28466 28467 28468 28469 28470 28471 2847 28512 541.7349 1081.4552 1081.4862 -0.0311 0 46 0.0014 1 K.FEMEQNLR.Q 28510 28511 28513 28514 28515 28516 28517 28518 29947 561.2858 1120.5569 1120.5764 -0.0195 0 59 7.5e-005 1 R.QEYEQLIAK.N 29944 9667 9669 9671 9672 29948 29949 9682 299 10598 579.2917 1156.5689 1156.5836 -0.0147 0 72 1.1e-005 1 R.QGVDADINGLR.Q 31111 31113 31116 10593 31118 31120 10594 10 32010 595.7911 1189.5675 1189.6013 -0.0337 0 (32) 0.033 1 R.QVLDNLTMEK.S 11420 32009 32436 603.7948 1205.5751 1205.5962 -0.0210 0 52 0.00033 1 R.QVLDNLTMEK.S 32424 32425 32426 32427 32428 32429 32430 324 33180 616.7852 1231.5559 1231.5906 -0.0346 0 126 1.4e-011 1 R.SGGGGGGGLGSGGSIR.S 12343 12345 33146 33148 33149 33150 33 33382 618.2593 1234.5040 1234.5215 -0.0174 0 106 1.2e-009 1 R.FSSSSGYGGGSSR.V 33330 33331 33332 33333 33334 33335 33336 35967 662.3296 1322.6446 1322.6652 -0.0206 1 47 0.00096 1 R.IKFEMEQNLR.Q 35957 35958 35959 35960 35961 35962 35966 35 36410 450.8911 1349.6516 1349.6800 -0.0284 1 23 0.25 1 K.IGLGGRGGSGGSYGR.G 36407 36409 36411 36412 36413 36414 39625 793.8649 1585.7153 1585.7583 -0.0430 0 83 2.3e-007 1 K.VQALEEANNDLENK.I 39626 39627 39628 41163 896.3439 1790.6733 1790.7205 -0.0472 0 106 4.6e-010 1 R.GGSGGSYGGGGSGGGYGGGSGSR.G 41149 41150 41151 41152 41153 4 41286 604.9474 1811.8204 1811.8511 -0.0307 1 31 0.026 1 R.SGGGGGGGLGSGGSIRSSYSR.F 41444 623.3004 1866.8794 1866.9145 -0.0351 1 21 0.24 1 K.TLNDMRQEYEQLIAK.N 12493 41605 485.5308 1938.0940 1937.9517 0.1423 1 16 0.68 1 K.TLLDIDNTRMTLDDFR.I 43277 837.3708 2509.0907 2509.1245 -0.0338 0 49 0.00023 1 K.EIETYHNLLEGGQEDFESSGAGK.I 43276 47855 1059.8411 3176.5016 3176.3756 0.1260 1 3 8 1 R.VCGRGGGGSFGYSYGGGSGGGFSASSLGGGFGGGSR.G 48089 1088.8366 3263.4879 3263.5066 -0.0187 0 23 0.061 1 K.DIENQYETQITQIEHEVSSSGQEVQSSAK.E

3. P35908|K22E_HUMAN Mass: 65678 Score: 10742 Queries matched: 559 emPAI: 3.93 Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 12 18043 416.2437 830.4728 830.4862 -0.0133 0 51 0.00061 1 R.SLVGLGGTK.S 18011 18015 18019 18021 18023 18024 18026 18027 25109 487.2633 972.5120 972.5240 -0.0120 0 60 6.8e-005 1 K.IEISELNR.V 6096 6099 25097 6101 25099 25100 6103 6104 25103 25573 497.7742 993.5339 993.5607 -0.0268 0 50 0.00056 1 R.LQGEIAHVK.K 25569 25570 25571 25572 25574 25575 25577 25578 25953 503.2272 1004.4399 1004.4597 -0.0198 0 49 0.00078 1 K.LLEGEECR.M 6832 25946 25947 25948 25949 25950 25951 25952 2

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26814 519.2561 1036.4977 1036.5189 -0.0212 0 37 0.011 1 R.YLDGLTAER.T 26813 7490 7491 7492 7495 7496 26816 28047 533.7466 1065.4786 1065.5090 -0.0305 1 51 0.00044 1 K.YEDEINKR.T 28043 28045 28046 28048 28049 28050 28051 28052 8411 534.7474 1067.4802 1067.4957 -0.0155 0 (15) 1.4 1 K.DVDNAYMIK.V 28118 8737 541.7932 1081.5718 1081.5920 -0.0203 1 43 0.0025 1 K.FASFIDKVR.F 28512 8735 8736 28573 542.7486 1083.4826 1083.4906 -0.0081 0 40 0.0048 1 K.DVDNAYMIK.V 8759 8760 8761 8762 8763 28568 8764 28569 8765 8 29597 554.2677 1106.5209 1106.5356 -0.0147 0 63 2.7e-005 1 K.AQYEEIAQR.S 29569 29570 29571 29573 29574 29575 29576 29577 30011 561.8254 1121.6363 1121.6557 -0.0193 1 53 0.0003 1 R.LQGEIAHVKK.Q 30009 30010 30013 9899 566.2456 1130.4767 1130.5026 -0.0259 0 71 9.5e-006 1 R.STSSFSCLSR.H 9895 30270 30271 30272 30273 9896 30274 30275 30402 567.2791 1132.5437 1132.5546 -0.0109 1 51 0.00047 1 R.KLLEGEECR.M 30332 30347 30348 30352 30363 30375 30377 30380 31059 578.2551 1154.4957 1154.5278 -0.0320 0 31 0.033 1 R.DYQELMNVK.L 10567 31057 31060 10571 31061 31062 31063 31064 11458 597.3081 1192.6016 1192.6088 -0.0072 0 49 0.0016 1 K.YEELQVTVGR.H 11447 11453 32074 32075 32076 32077 32078 1145 32254 599.2605 1196.5064 1196.5422 -0.0358 0 83 2.1e-007 1 K.GGSISGGGYGSGGGK.H 32241 32242 32243 32244 32245 32247 3224 32477 604.8048 1207.5951 1207.6085 -0.0134 0 84 2e-007 1 R.TAAENDFVTLK.K 11648 11649 11650 11651 11652 11653 11654 11 33846 627.8036 1253.5927 1253.6001 -0.0074 0 129 5.4e-012 1 R.GFSSGSAVVSGGSR.R 33799 33800 33802 33803 33804 33805 33806 34920 644.3058 1286.5970 1286.6037 -0.0068 1 36 0.013 1 R.RSTSSFSCLSR.H 34912 34913 34914 34915 34916 34917 34918 34 35913 660.7818 1319.5490 1319.5756 -0.0266 0 5 14 1 R.HGGGGGGFGGGGFGSR.S 36101 665.3095 1328.6044 1328.6320 -0.0276 0 53 0.00027 1 K.NVQDAIADAEQR.G 36098 36099 13328 36100 36102 36103 36104 3 36113 665.3616 1328.7087 1328.7187 -0.0100 0 70 4.6e-006 1 R.NLDLDSIIAEVK.A 36108 36109 36110 36111 36112 13331 36146 446.2306 1335.6700 1335.7034 -0.0334 1 68 6.7e-006 1 R.TAAENDFVTLKK.D 36138 36139 36140 36141 36142 36143 36144 3 13916 686.3490 1370.6834 1370.7041 -0.0207 0 27 0.3 1 K.LNDLEEALQQAK.E 37177 464.5639 1390.6698 1390.6728 -0.0030 1 49 0.00053 1 R.SKEEAEALYHSK.Y 37168 37169 37170 37171 37172 37173 37174 37 37588 705.8376 1409.6607 1409.7012 -0.0405 1 16 1 1 R.GFSSGSAVVSGGSRR.S 37590 38204 730.8953 1459.7761 1459.7922 -0.0161 0 96 1.2e-008 1 K.VDLLNQEIEFLK.V 38338 738.3789 1474.7433 1474.7780 -0.0347 0 108 7e-010 1 R.FLEQQNQVLQTK.W 38320 38322 38323 38324 38325 38326 38327 38 38803 497.5862 1489.7368 1489.8729 -0.1361 1 6 12 1 R.VIQRLQGEIAHVK.K 40914 870.8390 1739.6634 1739.6983 -0.0349 0 152 1.2e-014 1 R.GSSSGGGYSSGSSSYGSGGR.Q 40898 40899 40900 40901 40902 40903 42861 758.0039 2270.9898 2271.0325 -0.0427 1 32 0.013 1 R.TSQNSELNNM QDLVEDYKK.K

4. P04264|K2C1_HUMAN Mass: 66170 Score: 10395 Queries matched: 669 emPAI: 5.07 Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18062 416.7342 831.4538 831.4814 -0.0276 0 38 0.011 1 K.SISISVAR.G 18055 18056 18057 18059 18060 18061 18063 18064 22522 437.7443 873.4741 873.4920 -0.0179 0 61 6e-005 1 R.SLVNLGGSK.S 22487 22488 22489 22490 22491 22492 22493 22494 4355 448.2387 894.4628 894.4519 0.0109 1 5 69 1 R.TTSSSTRR.S 25109 487.2633 972.5120 972.5240 -0.0120 0 60 6.8e-005 1 K.IEISELNR.V 6096 6099 25097 6101 25099 25100 6103 6104 25103 25661 500.2201 998.4257 998.4379 -0.0121 0 49 0.00067 1 K.DVDGAYMTK.V 25644 25645 25646 25647 25649 25650 25651 25652 26050 508.2066 1014.3987 1014.4328 -0.0341 0 (36) 0.015 1 K.DVDGAYMTK.V 26051 26052 26053 26055 26763 517.2566 1032.4987 1032.5087 -0.0101 0 66 1.6e-005 1 R.TLLEGEESR.M 26700 26701 26702 26703 26704 26705 26706 26707 27971 533.2453 1064.4760 1064.5138 -0.0378 0 59 6.9e-005 1 K.AQYEDIAQK.S 8359 27954 27955 27957 27958 27959 27960 27962 28047 533.7466 1065.4786 1065.5090 -0.0305 1 51 0.00044 1 K.YEDEINKR.T 28043 28045 28046 28048 28049 28050 28051 28052 28268 537.2889 1072.5631 1072.5876 -0.0245 1 21 0.52 1 R.LRSEIDNVK.K 28234 28260 28261 28272 29013 546.7394 1091.4642 1091.4956 -0.0314 0 59 6.5e-005 1 R.GSGGGSSGGSIGGR.G 29012 29014 30077 563.2613 1124.5080 1124.5349 -0.0269 0 87 1e-007 1 K.AEAESLYQSK.Y 30056 30057 30058 30059 30060 30061 30062 300 30783 571.2591 1140.5037 1140.5121 -0.0084 0 (25) 0.14 1 R.DYQELMNTK.L 30778 10330 30782 30784 10340 31033 576.7709 1151.5272 1151.5458 -0.0186 1 4 19 2 R.NKYEDEINK.R 31102 579.2542 1156.4939 1156.5070 -0.0131 0 43 0.0025 1 R.DYQELMNTK.L 31080 31081 31082 31083 31084 31085 31086 31087 31171 580.2899 1158.5652 1158.6469 -0.0817 1 8 9.7 6 K.SISISVARGGGR.G 31167 31173 31175 31178 11157 590.2960 1178.5774 1178.5931 -0.0158 0 59 0.00021 1 K.YEELQITAGR.H 11138 11140 31856 31857 11147 31865 11148 318 11968 609.2881 1216.5617 1216.6088 -0.0472 0 16 3.5 1 K.FVSTTYSGVTR.- 34186 633.3121 1264.6096 1264.6299 -0.0203 0 84 1.9e-007 1 R.TNAENEFVTIK.K 12714 34156 34157 34158 34159 34160 12717 341 34625 639.3095 1276.6044 1276.6259 -0.0214 1 16 1.3 2 K.SDQSRLDSELK.N 34624 35374 651.8560 1301.6975 1301.7078 -0.0103 0 86 1.2e-007 1 R.SLDLDSIIAEVK.A 35356 35357 35358 35359 35360 35361 35362 35 13343 666.7415 1331.4684 1331.5122 -0.0438 0 3 21 3 K.NMQDMVEDYR.N 36244 670.8250 1339.6354 1339.6619 -0.0265 1 80 4.2e-007 1 K.SKAEAESLYQSK.Y 36211 36212 36213 36214 36215 36216 36217 3 36609 679.3362 1356.6579 1356.6885 -0.0305 0 60 4.9e-005 1 K.LNDLEDALQQAK.E 13789 36610 37044 692.3332 1382.6519 1382.6830 -0.0311 0 76 1.3e-006 1 K.SLNNQFASFIDK.V 13993 37042 37045 37046 37047 37048 13994 37 37273 697.3676 1392.7206 1392.7249 -0.0042 1 81 3.3e-007 1 R.TNAENEFVTIKK.D 37242 37243 37244 37245 37246 37247 37248 37 38318 738.3580 1474.7014 1474.7416 -0.0402 0 55 0.00013 1 K.WELLQQVDTSTR.T 38319 38321 38338 738.3789 1474.7433 1474.7780 -0.0347 0 108 7e-010 1 R.FLEQQNQVLQTK.W 38320 38322 38323 38324 38325 38326 38327 38 7518 520.2890 1557.8452 1557.6552 0.1900 1 6 38 2 K.NMQDMVEDYRNK.Y 40297 546.9535 1637.8386 1637.8525 -0.0139 1 34 0.015 1 K.SLNNQFASFIDKVR.F 9082 40414 829.3829 1656.7512 1656.7856 -0.0344 0 105 1.1e-009 1 R.SGGGFSSGSAGIINYQR.R 40409 40410 40411 40412 40413 40415 40 40594 563.3113 1686.9122 1686.9628 -0.0506 1 32 0.022 1 R.SLVNLGGSKSISISVAR.G 40760 572.9427 1715.8064 1715.8438 -0.0374 0 38 0.0059 1 K.QISNLQQSISDAEQR.G 41019 883.3459 1764.6771 1764.7275 -0.0503 0 61 1.5e-005 1 R.FSSCGGGGGSFGAGGGFGSR.S 11678 605.3092 1812.9057 1812.8867 0.0190 1 14 5.7 1 R.SGGGFSSGSAGIINYQRR.T 41750 665.3208 1992.9407 1992.9693 -0.0287 0 65 8.9e-006 1 R.THNLEPYFESFINNLR.R 42267 717.3612 2149.0618 2149.0705 -0.0086 1 16 0.73 1 R.THNLEPYFESFINNLRR.R 43035 795.2963 2382.8670 2382.9447 -0.0776 0 90 3.5e-009 1 R.GGGGGGYGSGGSSYGSGGGSYGSGGGGGGGR.G 43034 43037

5. P02533|K1C14_HUMAN Mass: 51872 Score: 6226 Queries matched: 378 emPAI: 1.84 Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 R.LAADDFR.T 121 16513 16514 16515 16516 16517 16518 16519 123 16720 405.2167 808.4188 808.4330 -0.0143 0 48 0.00086 1 R.LASYLDK.V 186 16697 16698 16699 16701 16702 16703 16704 167 18103 417.2108 832.4070 832.4290 -0.0220 0 31 0.051 1 K.SEISELR.R 1417 18100 18101 18104 1418 18105 18107 23808 460.2058 918.3971 918.4123 -0.0152 0 17 1.4 1 K.DYSPYFK.T 23809 5090 5091 23810 5092 25465 494.7688 987.5230 987.5349 -0.0119 1 20 0.59 1 K.TIEDLRNK.I 25464 25492 495.2658 988.5170 988.5301 -0.0131 1 26 0.16 1 K.SEISELRR.T 25473 25475 25476 25478 25479 25481 25483 25485 25894 501.7460 1001.4775 1001.4488 0.0287 0 11 5.6 8 R.QFTSSSSMK.G 26596 515.2859 1028.5573 1028.5866 -0.0293 0 43 0.0026 1 R.VLDELTLAR.A 26588 26590 7308 7309 26595 26598 7311 7315 731 27931 532.7949 1063.5752 1063.6026 -0.0274 1 59 6.6e-005 1 R.LASYLDKVR.A 27929 27930 27932 27933 27934 27935 27936 27937 28990 545.7648 1089.5150 1089.5237 -0.0087 0 59 7.7e-005 1 K.VTMQNLNDR.L 28950 28951 28952 28954 28955 28957 28958 2895 29453 553.7507 1105.4868 1105.5186 -0.0318 0 (44) 0.0025 1 K.VTMQNLNDR.L 29449 29450 29451 29452 29455 29456 29457 9434 29464 553.7656 1105.5166 1105.5550 -0.0384 0 76 1.5e-006 1 R.ISSVLAGGSCR.A 29454 29461 29463 29465 29466 29467 29468 294 9700 561.7727 1121.5308 1121.5717 -0.0408 0 58 8.7e-005 1 R.LEQEIATYR.R 30001 30002 30003 31083 579.2439 1156.4732 1156.5070 -0.0338 1 7 10 7 R.DQYEKMAEK.N 31082 31084 31085 31098 31102 32724 610.7832 1219.5519 1219.5932 -0.0412 0 78 7.8e-007 1 K.ASLENSLEETK.G 32726 32727 32728 32730 32731 32733 32734 327

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34646 639.7707 1277.5268 1277.5783 -0.0515 0 77 9.7e-007 1 K.GSCGIGGGIGGGSSR.I 34647 34648 34649 34651 34652 34653 3465 35326 651.3223 1300.6300 1300.6510 -0.0210 0 84 2e-007 1 R.ALEEANADLEVK.I 35304 35305 35307 35308 35309 35310 35311 35 36691 681.3375 1360.6605 1360.6834 -0.0229 0 116 1.3e-010 1 R.EVATNSELVQSGK.S 36670 36671 36672 36673 36674 36675 36676 3 37760 713.3546 1424.6946 1424.6896 0.0050 0 73 2.5e-006 1 R.APSTYGGGLSVSSSR.F 37717 37718 37719 37720 37721 37722 3772 37870 478.5741 1432.7005 1432.7157 -0.0152 1 55 0.00013 1 K.ASLENSLEETKGR.Y 37866 37867 37871 38156 727.8351 1453.6556 1453.6871 -0.0315 1 19 0.51 1 R.ILNEMRDQYEK.M 38154 38157 38158

6. P08779|K1C16_HUMAN Mass: 51578 Score: 4237 Queries matched: 347 emPAI: 2.05 Keratin, type I cytoskeletal 16 OS=Homo sapiens GN=KRT16 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 R.LAADDFR.T 121 16513 16514 16515 16516 16517 16518 16519 123 16720 405.2167 808.4188 808.4330 -0.0143 0 48 0.00086 1 R.LASYLDK.V 186 16697 16698 16699 16701 16702 16703 16704 167 18100 417.2090 832.4035 832.4290 -0.0255 0 31 0.052 1 R.SEVTELR.R 18101 18103 18104 1418 18105 18107 23808 460.2058 918.3971 918.4123 -0.0152 0 17 1.4 1 K.DYSPYFK.T 23809 5090 5091 23810 5092 25465 494.7688 987.5230 987.5349 -0.0119 1 20 0.59 1 K.TIEDLRNK.I 25464 25492 495.2658 988.5170 988.5301 -0.0131 1 16 1.5 2 R.SEVTELRR.V 25475 25476 25479 25481 25482 25485 25486 25489 25894 501.7460 1001.4775 1001.4488 0.0287 0 11 5.6 8 R.QFTSSSSMK.G 26596 515.2859 1028.5573 1028.5866 -0.0293 0 43 0.0026 1 R.VLDELTLAR.T 26588 26590 7308 7309 26595 26598 7311 7315 731 27931 532.7949 1063.5752 1063.6026 -0.0274 1 59 6.6e-005 1 R.LASYLDKVR.A 27929 27930 27932 27933 27934 27935 27936 27937 28990 545.7648 1089.5150 1089.5237 -0.0087 0 59 7.7e-005 1 K.VTMQNLNDR.L 28950 28951 28952 28954 28955 28957 28958 2895 9187 548.7619 1095.5093 1095.5237 -0.0143 0 15 1.4 1 R.DAETWFLSK.T 29453 553.7507 1105.4868 1105.5186 -0.0318 0 (44) 0.0025 1 K.VTMQNLNDR.L 29449 29450 29451 29452 29455 29456 29457 9434 29464 553.7656 1105.5166 1105.5550 -0.0384 0 76 1.5e-006 1 R.ISSVLAGGSCR.A 29454 29461 29463 29465 29466 29467 29468 294 9700 561.7727 1121.5308 1121.5717 -0.0408 0 58 8.7e-005 1 R.LEQEIATYR.R 30001 30002 30003 31083 579.2439 1156.4732 1156.4706 0.0025 0 7 10 7 R.DQYEQMAEK.N 31082 31085 31098 31102 32347 601.2979 1200.5812 1200.6099 -0.0287 0 28 0.079 1 R.QTVEADVNGLR.R 32349 32366 32371 32724 610.7832 1219.5519 1219.5932 -0.0412 0 78 7.8e-007 1 K.ASLENSLEETK.G 32726 32727 32728 32730 32731 32733 32734 327 33966 630.7668 1259.5190 1259.5630 -0.0440 0 52 0.00027 1 R.EVFTSSSSSSSR.Q 33963 33964 33965 33967 33968 33971 33973 33 34646 639.7707 1277.5268 1277.5783 -0.0515 0 77 9.7e-007 1 K.GSCGIGGGIGGGSSR.I 34647 34648 34649 34651 34652 34653 3465 35326 651.3223 1300.6300 1300.6510 -0.0210 0 84 2e-007 1 R.ALEEANADLEVK.I 35304 35305 35307 35308 35309 35310 35311 35 36198 669.8313 1337.6480 1337.6575 -0.0095 0 91 3.3e-008 1 R.APSTYGGGLSVSSR.F 3830 3935 36184 36185 36186 36187 3967 361 13788 679.3251 1356.6355 1356.7110 -0.0754 1 9 16 1 R.QTVEADVNGLRR.V 37526 703.3328 1404.6510 1404.6845 -0.0335 0 73 2e-006 1 K.EVASNSELVQSSR.S 37527 37528 37870 478.5741 1432.7005 1432.7157 -0.0152 1 55 0.00013 1 K.ASLENSLEETKGR.Y 37866 37867 37871

7. P13647|K2C5_HUMAN Mass: 62568 Score: 3540 Queries matched: 349 emPAI: 1.83 Keratin, type II cytoskeletal 5 OS=Homo sapiens GN=KRT5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 12 22825 442.7149 883.4152 883.4400 -0.0247 0 33 0.025 1 R.TSFTSVSR.S 22820 22821 22823 22824 22826 22827 22828 22829 4994 458.7176 915.4206 915.5025 -0.0819 1 2 44 5 R.AEIDNVKK.Q 24306 469.7427 937.4707 937.4869 -0.0161 0 15 1.6 2 R.SLYNLGGSK.R 24302 5424 24305 5426 5427 24310 24311 24312 24 24469 473.2409 944.4673 944.5039 -0.0367 1 36 0.018 1 R.GRLDSELR.N 24468 24470 24471 24472 24473 24474 24475 24476 25953 503.2272 1004.4399 1004.4597 -0.0198 0 49 0.00078 1 K.LLEGEECR.L 6832 25946 25947 25948 25949 25950 25951 25952 2 26121 508.7729 1015.5312 1015.5298 0.0014 0 58 0.0001 1 R.QLDSIVGER.G 26102 7026 7027 26103 7028 7029 7030 26104 2610 26428 513.7141 1025.4137 1025.4488 -0.0351 0 10 4.1 1 K.DVDAAYMNK.V 7587 521.7203 1041.4260 1041.4437 -0.0176 0 (8) 8.9 2 K.DVDAAYMNK.V 7580 7581 7582 26878 7584 26879 7586 7589 28047 533.7466 1065.4786 1065.5090 -0.0305 1 51 0.00044 1 K.YEDEINKR.T 28043 28045 28046 28048 28049 28050 28051 28052 8737 541.7932 1081.5718 1081.5920 -0.0203 1 43 0.0025 1 K.FASFIDKVR.F 28512 8735 8736 29064 547.2550 1092.4955 1092.5199 -0.0244 0 69 6.8e-006 1 K.AQYEEIANR.S 29039 29043 29045 29046 29047 29051 29058 2905 29122 547.7931 1093.5717 1093.5880 -0.0163 1 27 0.09 1 R.SLYNLGGSKR.I 9144 29120 29121 29123 29124 29722 556.2859 1110.5572 1110.5669 -0.0097 0 69 5.7e-006 1 R.ISISTSGGSFR.N 9501 29710 29711 9504 29713 9506 9507 29714 2 30402 567.2791 1132.5437 1132.5546 -0.0109 1 51 0.00047 1 R.KLLEGEECR.L 30332 30347 30348 30352 30363 30375 30377 30380 10413 572.3051 1142.5955 1142.6183 -0.0227 0 29 0.22 1 K.LAELEEALQK.A 10411 10412 10414 10415 31033 576.7709 1151.5272 1151.5458 -0.0186 1 4 19 2 K.NKYEDEINK.R 31436 585.7665 1169.5184 1169.5387 -0.0202 1 18 0.71 1 K.KDVDAAYMNK.V 31428 31430 31431 31433 31435 31437 31452 586.2542 1170.4938 1170.5227 -0.0288 0 20 0.56 1 R.EYQELMNTK.L 31448 31453 31454 32105 597.7805 1193.5465 1193.5676 -0.0211 0 88 8.3e-008 1 K.YEELQQTAGR.H 32089 32091 32092 32093 32094 32095 32096 320 32398 602.3100 1202.6055 1202.6295 -0.0240 0 41 0.0043 1 K.WTLLQEQGTK.T 11566 33643 621.7600 1241.5053 1241.5564 -0.0511 0 28 0.074 1 R.TEAESWYQTK.Y 33837 627.7985 1253.5824 1253.6113 -0.0289 1 14 2.1 2 R.QSSVSFRSGGSR.S 33799 33802 33803 33804 33805 33807 33809 33 35249 649.8078 1297.6011 1297.6224 -0.0213 0 20 0.47 1 R.TTAENEFVMLK.K 36113 665.3616 1328.7087 1328.7187 -0.0100 0 70 4.6e-006 1 R.NLDLDSIIAEVK.A 36108 36109 36110 36111 36112 13331 37579 705.8271 1409.6396 1409.6722 -0.0326 0 95 1.3e-008 1 R.VSLAGACGVGGYGSR.S 37573 37574 37575 37576 37577 37580 3758 37592 705.8529 1409.6913 1409.7151 -0.0238 0 71 2.9e-006 1 R.SFSTASAITPSVSR.T 5643 476.2389 1425.6948 1425.7173 -0.0226 1 22 1.4 1 R.TTAENEFVMLKK.D 5644 5645 37965 720.3459 1438.6772 1438.7053 -0.0280 0 58 6.2e-005 1 R.GLGVGFGSGGGSSSSVK.F 37964

8. Q04695|K1C17_HUMAN Mass: 48361 Score: 2830 Queries matched: 220 emPAI: 1.10 Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 R.LAADDFR.T 121 16513 16514 16515 16516 16517 16518 16519 123 16720 405.2167 808.4188 808.4330 -0.0143 0 48 0.00086 1 R.LASYLDK.V 186 16697 16698 16699 16701 16702 16703 16704 167 18103 417.2108 832.4070 832.4290 -0.0220 0 31 0.051 1 K.SEISELR.R 1417 18100 18101 18104 1418 18105 18107 25176 487.7459 973.4773 973.5080 -0.0307 0 23 0.32 1 R.TIEELQNK.I 25175 25177 25178 25181 25182 25183 25396 492.7348 983.4550 983.4924 -0.0374 0 29 0.072 2 R.QFTSSSSIK.G 25492 495.2658 988.5170 988.5301 -0.0131 1 26 0.16 1 K.SEISELRR.T 25473 25475 25476 25478 25479 25481 25483 25485 26596 515.2859 1028.5573 1028.5866 -0.0293 0 43 0.0026 1 R.VLDELTLAR.A 26588 26590 7308 7309 26595 26598 7311 7315 731 26795 517.7367 1033.4589 1033.4975 -0.0386 0 46 0.0014 1 R.LSGGLGAGSCR.L 7428 26794 26796 7429 7430 7431 7433 7434 27847 531.7362 1061.4578 1061.4924 -0.0345 0 37 0.012 1 K.ATMQNLNDR.L 27849 27931 532.7949 1063.5752 1063.6026 -0.0274 1 59 6.6e-005 1 R.LASYLDKVR.A 27929 27930 27932 27933 27934 27935 27936 27937 29840 559.2864 1116.5582 1116.5663 -0.0081 0 17 1.3 1 R.TIVEEVQDGK.V 9700 561.7727 1121.5308 1121.5717 -0.0408 0 58 8.7e-005 1 R.LEQEIATYR.R 30001 30002 30003 31083 579.2439 1156.4732 1156.5070 -0.0338 1 7 10 7 R.DQYEKMAEK.N 31082 31084 31085 31098 31102 36359 673.3489 1344.6833 1344.6772 0.0061 0 60 5.4e-005 1 R.ALEEANTELEVK.I 36356 36357 36691 681.3375 1360.6605 1360.6834 -0.0229 0 116 1.3e-010 1 R.EVATNSELVQSGK.S 36670 36671 36672 36673 36674 36675 36676 3 38156 727.8351 1453.6556 1453.6871 -0.0315 1 19 0.51 1 R.ILNEMRDQYEK.M 38154 38157 38158

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9. P04259|K2C6B_HUMAN Mass: 60315 Score: 2764 Queries matched: 263 emPAI: 2.31 Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 12 18119 418.7257 835.4368 835.4399 -0.0031 0 2 40 6 M.ASTSTTIR.S 22681 441.2246 880.4347 880.4654 -0.0307 0 51 0.0004 1 R.SLYGLGGSK.R 3469 24469 473.2409 944.4673 944.5039 -0.0367 1 36 0.018 1 R.GRLDSELR.N 24468 24470 24471 24472 24473 24474 24475 24476 24976 483.2339 964.4532 964.4839 -0.0306 1 21 0.46 1 R.RGFSANSAR.L 25076 486.7449 971.4752 971.5036 -0.0284 0 54 0.00026 1 K.QEIAEINR.M 25075 25078 25079 25080 6261 492.2750 982.5354 982.4753 0.0600 0 4 67 1 -.MASTSTTIR.S 25341 25953 503.2272 1004.4399 1004.4597 -0.0198 0 49 0.00078 1 K.LLEGEECR.L 6832 25946 25947 25948 25949 25950 25951 25952 2 26428 513.7141 1025.4137 1025.4488 -0.0351 0 10 4.1 1 K.DVDAAYMNK.V 26439 513.7585 1025.5025 1025.5142 -0.0117 0 69 5.6e-006 1 R.SGFSSISVSR.S 26431 26432 26433 26434 7234 26435 26436 26437 26818 519.2786 1036.5427 1036.5665 -0.0239 1 14 2 1 R.SLYGLGGSKR.I 26817 7502 7504 7587 521.7203 1041.4260 1041.4437 -0.0176 0 (8) 8.9 2 K.DVDAAYMNK.V 7580 7581 7582 26878 7584 26879 7586 7589 7607 522.2582 1042.5018 1042.5407 -0.0389 0 46 0.0043 1 R.QLDNIVGER.G 28047 533.7466 1065.4786 1065.5090 -0.0305 1 51 0.00044 1 K.YEDEINKR.T 28043 28045 28046 28048 28049 28050 28051 28052 8737 541.7932 1081.5718 1081.5920 -0.0203 1 43 0.0025 1 K.FASFIDKVR.F 28512 8735 8736 29597 554.2677 1106.5209 1106.5356 -0.0147 0 63 2.7e-005 1 K.AQYEEIAQR.S 29569 29570 29571 29573 29574 29575 29576 29577 30402 567.2791 1132.5437 1132.5546 -0.0109 1 51 0.00047 1 R.KLLEGEECR.L 30332 30347 30348 30352 30363 30375 30377 30380 31033 576.7709 1151.5272 1151.5458 -0.0186 1 4 19 2 K.NKYEDEINK.R 31436 585.7665 1169.5184 1169.5387 -0.0202 1 18 0.71 1 K.KDVDAAYMNK.V 31428 31430 31431 31433 31435 31437 11157 590.2960 1178.5774 1178.5931 -0.0158 0 59 0.00021 1 K.YEELQITAGR.H 11138 11140 31856 31857 11147 31865 11148 318 32398 602.3100 1202.6055 1202.6295 -0.0240 0 41 0.0043 1 K.WTLLQEQGTK.T 11566 33054 611.8007 1221.5869 1221.6241 -0.0372 0 61 4.4e-005 1 R.TAAENEFVTLK.K 33055 33059 33060 36113 665.3616 1328.7087 1328.7187 -0.0100 0 70 4.6e-006 1 R.NLDLDSIIAEVK.A 36108 36109 36110 36111 36112 13331 36417 675.8542 1349.6938 1349.7191 -0.0253 1 48 0.00085 1 R.TAAENEFVTLKK.D 37709 712.7937 1423.5729 1423.6263 -0.0534 0 48 0.00052 1 R.GSGGLGGACGGAGFGSR.S 37900 718.3422 1434.6698 1434.7315 -0.0617 0 85 1.3e-007 1 R.ATGGGLSSVGGGSSTIK.Y 37899 37901 37902 37903 37904 37905 37 39699 799.8713 1597.7281 1597.7519 -0.0237 0 109 4.4e-010 1 R.ISIGGGSCAISGGYGSR.A 39694 39695 39696 39697 39698 39701 39

10. P02538|K2C6A_HUMAN Mass: 60293 Score: 2709 Queries matched: 273 emPAI: 2.52 Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 12 18119 418.7257 835.4368 835.4399 -0.0031 0 2 40 6 M.ASTSTTIR.S 22681 441.2246 880.4347 880.4654 -0.0307 0 51 0.0004 1 R.SLYGLGGSK.R 3469 24469 473.2409 944.4673 944.5039 -0.0367 1 36 0.018 1 R.GRLDSELR.G 24468 24470 24471 24472 24473 24474 24475 24476 24976 483.2339 964.4532 964.4839 -0.0306 1 21 0.46 1 R.RGFSANSAR.L 25076 486.7449 971.4752 971.5036 -0.0284 0 54 0.00026 1 K.QEIAEINR.M 25075 25078 25079 25080 6261 492.2750 982.5354 982.4753 0.0600 0 4 67 1 -.MASTSTTIR.S 25341 25953 503.2272 1004.4399 1004.4597 -0.0198 0 49 0.00078 1 K.LLEGEECR.L 6832 25946 25947 25948 25949 25950 25951 25952 2 26024 506.7472 1011.4799 1011.4985 -0.0186 0 87 1.1e-007 1 R.SGFSSVSVSR.S 26013 26014 26015 26016 26017 26018 26019 2602 26121 508.7729 1015.5312 1015.5298 0.0014 0 58 0.0001 1 R.QLDSIVGER.G 26102 7026 7027 26103 7028 7029 7030 26104 2610 26428 513.7141 1025.4137 1025.4488 -0.0351 0 10 4.1 1 K.DVDAAYMNK.V 26818 519.2786 1036.5427 1036.5665 -0.0239 1 14 2 1 R.SLYGLGGSKR.I 26817 7502 7504 7587 521.7203 1041.4260 1041.4437 -0.0176 0 (8) 8.9 2 K.DVDAAYMNK.V 7580 7581 7582 26878 7584 26879 7586 7589 28047 533.7466 1065.4786 1065.5090 -0.0305 1 51 0.00044 1 K.YEDEINKR.T 28043 28045 28046 28048 28049 28050 28051 28052 8737 541.7932 1081.5718 1081.5920 -0.0203 1 43 0.0025 1 K.FASFIDKVR.F 28512 8735 8736 29597 554.2677 1106.5209 1106.5356 -0.0147 0 63 2.7e-005 1 K.AQYEEIAQR.S 29569 29570 29571 29573 29574 29575 29576 29577 30402 567.2791 1132.5437 1132.5546 -0.0109 1 51 0.00047 1 R.KLLEGEECR.L 30332 30347 30348 30352 30363 30375 30377 30380 31033 576.7709 1151.5272 1151.5458 -0.0186 1 4 19 2 K.NKYEDEINK.R 31340 583.2750 1164.5354 1164.5775 -0.0420 0 61 3.8e-005 1 K.YEELQVTAGR.H 31355 31362 31366 31370 31436 585.7665 1169.5184 1169.5387 -0.0202 1 18 0.71 1 K.KDVDAAYMNK.V 31428 31430 31431 31433 31435 31437 32398 602.3100 1202.6055 1202.6295 -0.0240 0 41 0.0043 1 K.WTLLQEQGTK.T 11566 33054 611.8007 1221.5869 1221.6241 -0.0372 0 61 4.4e-005 1 R.TAAENEFVTLK.K 33055 33059 33060 36113 665.3616 1328.7087 1328.7187 -0.0100 0 70 4.6e-006 1 R.NLDLDSIIAEVK.A 36108 36109 36110 36111 36112 13331 36417 675.8542 1349.6938 1349.7191 -0.0253 1 48 0.00085 1 R.TAAENEFVTLKK.D 37709 712.7937 1423.5729 1423.6263 -0.0534 0 48 0.00052 1 R.GSGGLGGACGGAGFGSR.S 38122 724.3630 1446.7114 1446.7678 -0.0564 0 83 2.2e-007 1 R.AIGGGLSSVGGGSSTIK.Y 38120 38121 38123 38124 38125 38126 38 38366 738.8789 1475.7431 1475.7984 -0.0552 1 31 0.04 1 R.FLEQQNKVLETK.W 38363 38365 38367 39699 799.8713 1597.7281 1597.7519 -0.0237 0 109 4.4e-010 1 R.ISIGGGSCAISGGYGSR.A 39694 39695 39696 39697 39698 39701 39

11. P02649|APOE_HUMAN Mass: 36246 Score: 2114 Queries matched: 98 emPAI: 1.96 Apolipoprotein E OS=Homo sapiens GN=APOE PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23251 450.2177 898.4209 898.4337 -0.0128 0 10 5.3 2 R.FWDYLR.W 4501 5294 465.7468 929.4790 929.4971 -0.0181 0 35 0.023 1 R.QWAGLVEK.V 5293 24527 474.7565 947.4984 947.5188 -0.0205 0 60 5.7e-005 1 R.LAVYQAGAR.E 24515 24516 24517 24518 24519 24520 24521 24522 25022 484.7703 967.5261 967.5451 -0.0190 0 52 0.0003 1 R.LGPLVEQGR.V 25007 25008 25009 25010 25011 25012 25013 25014 26785 517.2663 1032.5180 1032.5352 -0.0172 0 52 0.0004 1 R.LQAEAFQAR.L 26748 26771 26774 26775 26776 26778 26780 26781 29398 552.8041 1103.5936 1103.6199 -0.0264 1 14 2.3 1 K.RLAVYQAGAR.E 29783 557.7864 1113.5583 1113.5778 -0.0195 0 69 7.3e-006 1 K.LEEQAQQIR.L 29767 29773 29774 29776 29778 29779 29786 29787 33045 611.7897 1221.5648 1221.5118 0.0530 0 (0) 46 6 R.LGADMEDVCGR.L 33544 619.7405 1237.4664 1237.5067 -0.0403 0 80 3.1e-007 1 R.LGADMEDVCGR.L 33545 33546 33547 33548 33549 33550 33551 33677 624.2666 1246.5187 1246.5691 -0.0504 0 57 8.9e-005 1 R.QQTEWQSGQR.W 33684 33686 33689 33691 33692 35817 657.3507 1312.6869 1312.7099 -0.0230 1 93 2.5e-008 1 R.AKLEEQAQQIR.L 35812 35813 35814 35815 35816 35818 35819 358 5538 472.2483 1413.7230 1413.7463 -0.0234 1 29 0.22 1 R.LDEVKEQVAEVR.A 38916 749.3887 1496.7628 1496.7947 -0.0318 0 105 1.2e-009 1 R.AATVGSLAGQPLQER.A 38917 39837 810.8958 1619.7770 1619.7904 -0.0134 0 113 1.8e-010 1 K.VQAAVGTSAAPVPSDNH.- 39831 39832 39833 39834 39835 39836 12932 640.2665 1917.7776 1917.9578 -0.1802 1 1 77 1 R.GEVQAMLGQSTEELRVR.L

12. P19012|K1C15_HUMAN Mass: 49395 Score: 1684 Queries matched: 167 emPAI: 0.55 Keratin, type I cytoskeletal 15 OS=Homo sapiens GN=KRT15 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1

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R.LAADDFR.L 121 16513 16514 16515 16516 16517 16518 16519 123 16720 405.2167 808.4188 808.4330 -0.0143 0 48 0.00086 1 R.LASYLDK.V 186 16697 16698 16699 16701 16702 16703 16704 167 24871 480.7463 959.4780 959.4924 -0.0143 0 19 0.89 2 R.SLLEGQDAK.M 26596 515.2859 1028.5573 1028.5866 -0.0293 0 43 0.0026 1 R.VLDELTLAR.T 26588 26590 7308 7309 26595 26598 7311 7315 731 7594 521.7835 1041.5524 1041.5818 -0.0294 0 9 7.1 1 R.VILEIDNAR.L 7596 27931 532.7949 1063.5752 1063.6026 -0.0274 1 59 6.6e-005 1 R.LASYLDKVR.A 27929 27930 27932 27933 27934 27935 27936 27937 9700 561.7727 1121.5308 1121.5717 -0.0408 0 58 8.7e-005 1 R.LEQEIATYR.S 30001 30002 30003 35326 651.3223 1300.6300 1300.6510 -0.0210 0 84 2e-007 1 R.ALEEANADLEVK.I 35304 35305 35307 35308 35309 35310 35311 35

13. P02768|ALBU_HUMAN Mass: 71317 Score: 1309 Queries matched: 138 emPAI: 1.14 Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12983 645.2307 644.2234 644.3493 -0.1259 0 2 77 1 K.LDELR.D 22578 438.2467 874.4788 874.5025 -0.0236 1 23 0.35 1 R.LSQRFPK.A 22581 22582 22583 22652 440.7172 879.4198 879.4338 -0.0139 0 54 0.00022 1 K.AEFAEVSK.L 22640 22641 22642 22643 22644 22645 22646 22647 23995 464.2427 926.4709 926.4861 -0.0153 0 32 0.03 1 K.YLYEIAR.R 23987 23988 23989 23990 23991 23992 23994 23996 2 24266 467.2559 932.4972 932.5113 -0.0141 0 23 0.34 1 K.LCTVATLR.E 24404 470.7194 939.4241 939.4410 -0.0168 0 36 0.014 1 K.DDNPNLPR.L 24405 24553 476.2225 950.4305 950.4345 -0.0040 0 11 5.1 1 K.DLGEENFK.A 25398 492.7377 983.4608 983.4811 -0.0203 0 35 0.017 1 K.TYETTLEK.C 25397 25400 6723 501.7678 1001.5211 1001.5506 -0.0295 1 27 0.14 1 K.TPVSDRVTK.C 28305 537.7691 1073.5236 1073.5353 -0.0117 1 38 0.0086 1 K.LDELRDEGK.A 28285 28293 28301 28304 28306 28307 28309 30738 569.7397 1137.4649 1137.4907 -0.0257 0 38 0.0072 1 K.CCTESLVNR.R 30737 30739 30740 30741 30742 30743 30744 30745 10399 571.4429 1140.8713 1140.6866 0.1847 1 2 24 1 K.KLVAASQAALGL.- 30902 575.3009 1148.5872 1148.6077 -0.0205 0 33 0.025 1 K.LVNEVTEFAK.T 10454 30897 10455 10456 30899 30900 30901 3090 36900 686.2713 1370.5281 1370.5595 -0.0314 0 65 8.5e-006 1 K.AAFTECCQAADK.A 36899 38082 722.3160 1442.6174 1442.6347 -0.0173 0 74 1.5e-006 1 K.YICENQDSISSK.L 38055 38056 38057 38058 38059 38060 38061 38 14219 725.7520 1449.4894 1449.5210 -0.0317 0 5 10 1 R.ETYGEMADCCAK.Q 38925 749.7772 1497.5399 1497.5712 -0.0312 0 77 3.3e-007 1 K.TCVADESAENCDK.S 16393 38919 38920 38921 38922 38923 38924 3 39054 756.4131 1510.8116 1510.8355 -0.0239 0 80 4e-007 1 K.VPQVSTPTLVEVSR.N 39053 39055 40299 547.3000 1638.8781 1638.9305 -0.0523 1 65 1.1e-005 1 K.KVPQVSTPTLVEVSR.N 9106 40298 9108 9109 40300 40301 40302

14. P13646|K1C13_HUMAN Mass: 49900 Score: 1233 Queries matched: 114 emPAI: 0.33 Keratin, type I cytoskeletal 13 OS=Homo sapiens GN=KRT13 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 R.LAADDFR.L 121 16513 16514 16515 16516 16517 16518 16519 123 778 412.2223 822.4300 822.4487 -0.0187 0 25 0.45 1 R.LASYLEK.V 17471 3253 436.2507 870.4869 870.4195 0.0674 0 6 41 2 K.QSPASPER.D 22372 3254 3271 3273 24871 480.7463 959.4780 959.4924 -0.0143 0 19 0.89 2 R.SLLEGQDAK.M 26154 509.2804 1016.5462 1016.5754 -0.0292 0 13 3.2 1 R.VLDELTLSK.T 7594 521.7835 1041.5524 1041.5818 -0.0294 0 9 7.1 1 R.VILEIDNAR.L 7596 9700 561.7727 1121.5308 1121.5717 -0.0408 0 58 8.7e-005 1 R.LEQEIATYR.S 30001 30002 30003 30136 563.7760 1125.5375 1125.4760 0.0615 0 1 42 6 R.EQYEAMAER.N 30143 32349 601.3042 1200.5939 1200.6098 -0.0160 0 65 1.6e-005 1 R.QSVEADINGLR.R 11551 32348 11552 32352 35326 651.3223 1300.6300 1300.6510 -0.0210 0 84 2e-007 1 R.ALEEANADLEVK.I 35304 35305 35307 35308 35309 35310 35311 35 13794 679.3609 1356.7073 1356.7110 -0.0037 1 18 1.9 1 R.QSVEADINGLRR.V 4664 36612 36614 36615

15. Q7Z3Y7|K1C28_HUMAN Mass: 51191 Score: 862 Queries matched: 131 emPAI: 0.42 Keratin, type I cytoskeletal 28 OS=Homo sapiens GN=KRT28 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 R.LAADDFR.L 121 16513 16514 16515 16516 16517 16518 16519 123 22743 441.7205 881.4264 881.4277 -0.0012 1 1 39 7 K.TSKMTNGK.T 28990 545.7648 1089.5150 1089.5237 -0.0087 0 59 7.7e-005 1 K.VTMQNLNDR.L 28950 28951 28952 28954 28955 28957 28958 2895 29453 553.7507 1105.4868 1105.5186 -0.0318 0 (44) 0.0025 1 K.VTMQNLNDR.L 29449 29450 29451 29452 29455 29456 29457 9434 29646 555.2396 1108.4647 1108.4825 -0.0178 0 41 0.0038 1 K.DAEAWFNEK.S 29633 9467 9468 29639 9470 29642 29643 29644 29 33504 619.2807 1236.5468 1236.5775 -0.0307 1 28 0.074 1 R.KDAEAWFNEK.S 35152 432.8738 1295.5995 1295.6106 -0.0111 1 0 43 1 K.SKGFGSGSPGNSSK.D

16. P61626|LYSC_HUMAN Mass: 16982 Score: 783 Queries matched: 41 emPAI: 3.22 Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16746 406.1811 810.3477 810.3694 -0.0217 0 48 0.0008 1 R.LGMDGYR.G 221 16745 16747 16748 16749 16750 16751 16752 17923 414.2093 826.4040 826.3643 0.0396 0 (4) 20 2 R.LGMDGYR.G 23582 455.6991 909.3837 909.4015 -0.0178 0 46 0.0014 1 R.QYVQGCGV.- 23580 23581 23583 23584 23585 24424 471.6834 941.3522 941.3701 -0.0180 0 27 0.084 1 R.YWCNDGK.T 24423 26012 506.7145 1011.4145 1011.4410 -0.0265 0 34 0.02 1 K.WESGYNTR.A 26833 520.2935 1038.5725 1038.5934 -0.0209 1 30 0.053 1 R.VVRDPQGIR.A 26829 26830 26831 26832 26834 37488 700.8263 1399.6381 1399.6732 -0.0351 0 91 3.6e-008 1 R.STDYGIFQINSR.Y 37480 37481 37482 37483 37484 37485 37486 37

17. P36222|CH3L1_HUMAN Mass: 42998 Score: 731 Queries matched: 50 emPAI: 0.65 Chitinase-3-like protein 1 OS=Homo sapiens GN=CHI3L1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 278 408.2349 814.4553 814.4701 -0.0149 0 15 4.7 1 K.SVPPFLR.T 17010 17011 280 17014 17015 23472 452.2622 902.5099 902.5225 -0.0127 0 19 0.76 1 R.FPLTNAIK.D 4630 23469 4631 23470 23471 4632 23473 23820 461.2489 920.4832 920.5080 -0.0247 1 9 7.3 1 K.VQYLKDR.Q 23822 29493 553.7964 1105.5782 1105.5954 -0.0172 0 21 0.44 1 K.LVMGIPTFGR.S 9436 29491 29492 32486 403.8686 1208.5839 1208.6051 -0.0211 0 35 0.015 1 R.GTTGHHSPLFR.G 32484 32485 32487 32493 606.2990 1210.5834 1210.6081 -0.0247 0 61 3.5e-005 1 K.VTIDSSYDIAK.I 11704 32492 32494 32495 11706 11708 32652 609.3318 1216.6490 1216.6816 -0.0326 0 69 5.9e-006 1 R.ILGQQVPYATK.G 32634 32640 32648 11986 32649 32651 32654 32 37935 719.7824 1437.5502 1437.5831 -0.0328 0 87 5.5e-008 1 R.EGDGSCFPDALDR.F 37933 37934 37936 37937 39851 812.8448 1623.6750 1623.7165 -0.0415 0 50 0.0003 1 K.GNQWVGYDDQESVK.S 39852 42343 1079.5429 2157.0712 2157.1066 -0.0354 0 98 4.2e-009 1 R.SFTLASSETGVGAPISGPGIPGR.F

18. P60709|ACTB_HUMAN Mass: 42052 Score: 673 Queries matched: 58 emPAI: 0.98 Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12976 644.3266 643.3193 643.3653 -0.0460 0 13 5.1 1 R.LDLAGR.D 12975 23894 462.2793 922.5441 922.5600 -0.0159 1 15 1.8 1 K.IIAPPERK.Y 25253 488.7235 975.4325 975.4410 -0.0085 0 73 3.4e-006 1 K.AGFAGDDAPR.A 25240 25241 25242 25243 25244 25245 25246 2524 26042 507.7343 1013.4540 1013.4739 -0.0199 0 17 1.1 1 R.DLTDYLMK.I 6975 26041 6977 6978 30308 566.7567 1131.4989 1131.5197 -0.0207 0 60 4.8e-005 1 R.GYSFTTTAER.E 30306 30307 30309 30310 30311 30312 30314 3031 10674 581.2948 1160.5750 1160.6111 -0.0360 0 (24) 0.53 1 K.EITALAPSTMK.I 31535 589.2957 1176.5767 1176.6060 -0.0293 0 29 0.061 1 K.EITALAPSTMK.I 31531 31534 31537 31538 31539 31540 31541 32314 599.7486 1197.4827 1197.5150 -0.0322 0 27 0.084 1 K.DSYVGDEAQSK.R 32313 32320 32325 32328 400.2347 1197.6824 1197.6982 -0.0159 0 18 0.81 1 R.AVFPSIVGRPR.H 32327 36592 677.8042 1353.5938 1353.6161 -0.0223 1 27 0.093 1 K.DSYVGDEAQSKR.G 36589 36590 36591 13768 41645 652.0117 1953.0133 1953.0571 -0.0438 0 38 0.0046 1 R.VAPEEHPVLLTEAPLNPK.A 41644 13100

Proteins matching the same set of peptides: P63261|ACTG_HUMAN Mass: 42108 Score: 673 Queries matched: 58 Actin, cytoplasmic 2 OS=Homo sapiens GN=ACTG1 PE=1 SV=1

19. Q7Z3Y8|K1C27_HUMAN Mass: 50420 Score: 643 Queries matched: 93 emPAI: 0.33 Keratin, type I cytoskeletal 27 OS=Homo sapiens GN=KRT27 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1898 421.2120 840.4093 840.4341 -0.0248 0 5 41 1 R.VHTVEEK.S 18906 27931 532.7949 1063.5752 1063.5662 0.0090 0 46 0.0015 2 R.LASYLENVR.A 27929 27930 27932 27933 27934 27935 27936 27937 28990 545.7648 1089.5150 1089.5237 -0.0087 0 59 7.7e-005 1 K.VTMQNLNDR.L 28950 28951 28952 28954 28955 28957 28958 2895 29453 553.7507 1105.4868 1105.5186 -0.0318 0 (44) 0.0025 1 K.VTMQNLNDR.L 29449 29450 29451 29452 29455 29456 29457 9434 29646 555.2396 1108.4647 1108.4825 -0.0178 0 41 0.0038 1 R.DAEAWFNEK.S 29633 9467 9468 29639 9470 29642 29643 29644 29

20. P19013|K2C4_HUMAN Mass: 57649 Score: 595 Queries matched: 86 emPAI: 0.21 Keratin, type II cytoskeletal 4 OS=Homo sapiens GN=KRT4 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 12 25505 495.7867 989.5588 989.5757 -0.0169 0 19 0.84 1 K.IISTTTLNK.R 25940 502.2786 1002.5426 1002.4982 0.0444 0 7 12 7 K.QLDTLGNDK.G 26002 505.7416 1009.4686 1009.4862 -0.0177 0 25 0.13 1 K.SISMSVAGSR.Q 26001 26003 26004 29597 554.2677 1106.5209 1106.5356 -0.0147 0 63 2.7e-005 1 R.AQYEEIAQR.S 29569 29570 29571 29573 29574 29575 29576 29577 9952 567.2756 1132.5366 1132.5877 -0.0511 0 23 0.71 1 K.VQFLEQQNK.V 30325 30329 30334 30335 30338 30339 30341 30342 34908 643.7760 1285.5375 1285.5721 -0.0346 0 35 0.016 1 R.GAFSSVSMSGGAGR.C 36609 679.3362 1356.6579 1356.7249 -0.0669 0 24 0.21 2 R.NLDLDSIIAEVR.A 13789 36610

21. Q5D862|FILA2_HUMAN Mass: 249296 Score: 583 Queries matched: 25 emPAI: 0.01 Filaggrin-2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9651 560.3354 559.3281 559.3190 0.0091 1 0 1e+002 1 R.TAGRR.G 35919 660.7896 1319.5647 1319.5630 0.0017 0 80 4.6e-007 1 R.FSNSSSSNEFSK.C 35899 35900 35901 35902 35903 35904 35905 35 38127 724.3776 1446.7406 1446.8446 -0.1039 1 4 19 7 K.ELLEKELHPVLK.N 38128 38130 5953 39146 761.3524 1520.6902 1520.7141 -0.0239 1 4 15 6 K.QDGECGTLSKGELK.E 39139

22. Q86Y46|K2C73_HUMAN Mass: 59457 Score: 562 Queries matched: 112 emPAI: 0.44 Keratin, type II cytoskeletal 73 OS=Homo sapiens GN=KRT73 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10845 587.3160 586.3087 586.3438 -0.0352 0 2 51 1 K.VLNNK.F 13917 686.3691 685.3618 685.3435 0.0183 0 1 58 3 R.QFTYK.S 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 126 20712 433.7249 865.4351 865.4294 0.0058 0 3 30 1 R.LGSASEFR.D 3493 441.2614 880.5083 880.4178 0.0905 0 2 78 2 R.EVVEDYK.K 25953 503.2272 1004.4399 1004.4597 -0.0198 0 49 0.00078 1 K.LLEGEECR.M 6832 25946 25947 25948 25949 25950 25951 25952 25 28310 537.7745 1073.5343 1073.5829 -0.0486 1 3 28 1 R.LDSELRSVR.E 28278 8737 541.7932 1081.5718 1081.5920 -0.0203 1 43 0.0025 1 K.FASFIDKVR.F 28512 8735 8736 29597 554.2677 1106.5209 1106.5720 -0.0511 1 56 0.00016 2 R.AQYEEIARK.S 29569 29570 29571 29573 29574 29575 29576 29577 30402 567.2791 1132.5437 1132.5546 -0.0109 1 51 0.00047 1 R.KLLEGEECR.M 30332 30347 30348 30352 30363 30375 30377 30380 36609 679.3362 1356.6579 1356.7249 -0.0669 0 24 0.21 2 R.NLDLDSIIAEVR.A 13789 36610 38366 738.8789 1475.7431 1475.7620 -0.0188 0 31 0.04 1 R.FLEQQNQVLETK.W 38363 38365 38367

23. P08670|VIME_HUMAN Mass: 53676 Score: 532 Queries matched: 40 emPAI: 0.31 Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24257 466.7308 931.4471 931.4610 -0.0139 0 34 0.025 1 K.LLEGEESR.I 24250 24251 24252 24253 24254 24255 24256 24258 27741 530.7839 1059.5531 1059.5560 -0.0029 1 8 11 6 R.KLLEGEESR.I 8261 28662 544.7604 1087.5063 1087.5258 -0.0195 0 76 1.6e-006 1 R.QDVDNASLAR.L 28655 28656 28657 28659 28660 28663 28664 286 29086 547.2600 1092.5053 1092.5200 -0.0146 0 67 9.6e-006 1 K.FADLSEAANR.N 29031 29044 29052 29053 29060 29063 29065 290 35881 660.2929 1318.5712 1318.6551 -0.0838 1 1 37 2 R.EKLQEEMLQR.E 35954 662.2989 1322.5833 1322.6102 -0.0269 0 43 0.0023 1 R.EEAENTLQSFR.Q 37527 703.3331 1404.6516 1404.7500 -0.0984 0 0 40 6 K.VESLQEEIAFLK.K 38916 749.3887 1496.7628 1496.6929 0.0699 1 6 12 4 K.SRLGDLYEEEMR.E 11099 589.5403 1765.5989 1765.7974 -0.1985 1 1 38 1 R.LQDEIQNMKEEMAR.H

24. P81605|DCD_HUMAN Mass: 11391 Score: 528 Queries matched: 33 emPAI: 0.82 Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23377 450.2640 898.5135 898.5600 -0.0465 1 6 12 8 K.AVGGLGKLGK.D 30212 564.7535 1127.4924 1127.5207 -0.0283 0 61 4.1e-005 1 K.ENAGEDPGLAR.Q 30205 30206 30207 30208 30209 30210 30211 302 10662 581.2548 1160.4950 1160.5561 -0.0611 0 46 0.0035 1 K.DAVEDLESVGK.G 10661 10667

25. Q99456|K1C12_HUMAN Mass: 53592 Score: 510 Queries matched: 91 emPAI: 0.22 Keratin, type I cytoskeletal 12 OS=Homo sapiens GN=KRT12 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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16720 405.2167 808.4188 808.4330 -0.0143 0 48 0.00086 1 R.LASYLDK.V 186 16697 16698 16699 16701 16702 16703 16704 167 27653 530.2602 1058.5058 1058.5972 -0.0914 0 3 27 9 R.VLDELTLTR.T 27931 532.7949 1063.5752 1063.6026 -0.0274 1 59 6.6e-005 1 R.LASYLDKVR.A 27929 27930 27932 27933 27934 27935 27936 27937 31359 583.2870 1164.5594 1164.6026 -0.0432 0 31 0.036 2 R.LELEIETYR.R 31336 31338 31339 10708 31342 31343 31344 31345 6365 495.2503 1482.7292 1482.6806 0.0485 0 2 80 1 -.MDLSNNTMSLSVR.T

26. P14780|MMP9_HUMAN Mass: 79492 Score: 444 Queries matched: 28 emPAI: 0.89 Matrix metalloproteinase-9 OS=Homo sapiens GN=MMP9 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16384 747.3757 746.3684 746.3857 -0.0173 1 0 78 9 K.AMRTPR.C 18310 420.2203 838.4260 838.4371 -0.0111 0 3 24 3 K.MLLFSGR.R 22473 437.2149 872.4152 872.4175 -0.0023 0 9 9.6 2 R.CGVPDLGR.F 24850 480.1953 958.3761 958.3967 -0.0206 0 19 0.68 1 K.AYFCQDR.F 24849 25265 489.2553 976.4960 976.4978 -0.0018 0 50 0.00068 1 R.AVIDDAFAR.A 25263 25264 6176 6177 6178 6180 6535 499.2517 996.4889 996.4851 0.0038 0 21 1 1 K.LFGFCPTR.A 25711 501.2718 1000.5290 1000.5494 -0.0204 1 10 5.6 4 K.KLFFFSGR.Q 26410 513.2640 1024.5134 1024.5342 -0.0208 0 37 0.011 1 R.FTEGPPLHK.D 8769 542.7583 1083.5020 1083.5237 -0.0217 0 39 0.0063 1 R.FQTFEGDLK.W 28577 30000 561.7816 1121.5487 1121.5717 -0.0230 1 46 0.0013 1 R.KLDSVFEER.L 31035 576.8600 1151.7055 1151.7278 -0.0223 0 66 1.1e-005 1 K.SLGPALLLLQK.Q 31938 592.7902 1183.5659 1183.5873 -0.0214 0 45 0.0016 1 R.QLAEEYLYR.Y 31936 36360 673.3565 1344.6985 1344.7402 -0.0417 0 68 8.6e-006 1 R.QSTLVLFPGDLR.T 36361 37061 693.3679 1384.7212 1384.7463 -0.0250 0 38 0.0079 1 R.GSRPQGPFLIADK.W 37969 720.9018 1439.7891 1439.8096 -0.0206 0 81 3e-007 1 K.LGLGADVAQVTGALR.S 40540 558.2502 1671.7287 1671.7563 -0.0276 1 29 0.044 1 R.LWCATTSNFDSDKK.W 40565 840.9525 1679.8905 1679.9035 -0.0130 0 52 0.00024 1 R.AFALWSAVTPLTFTR.V 40678 851.4308 1700.8471 1700.8832 -0.0362 0 76 9.2e-007 1 K.QLSLPETGELDSATLK.A

27. Q6S8J3|POTEE_HUMAN Mass: 122882 Score: 439 Queries matched: 58 emPAI: 0.06 POTE ankyrin domain family member E OS=Homo sapiens GN=POTEE PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12976 644.3266 643.3193 643.3653 -0.0460 0 13 5.1 1 R.LDLAGR.E 12975 3394 438.2449 874.4752 874.4946 -0.0194 0 14 5.9 1 K.DLIVMLR.D 3395 22591 25253 488.7235 975.4325 975.4410 -0.0085 0 73 3.4e-006 1 K.AGFAGDDAPR.A 25240 25241 25242 25243 25244 25245 25246 2524 29603 554.2721 1106.5296 1106.5277 0.0019 0 15 1.7 4 K.MSQELEINK.D 29570 29573 29574 29575 29576 29577 29579 29581 11353 593.8012 1185.5878 1185.5989 -0.0111 1 0 52 6 R.LKGSENGQPEK.R 32328 400.2347 1197.6824 1197.6982 -0.0159 0 18 0.81 1 R.AVFPSIVGRPR.Q 32327 33164 616.7803 1231.5461 1231.5260 0.0201 0 4 20 7 R.QQGMMGGMHQK.E 33167 33220 36158 668.8515 1335.6885 1335.5612 0.1273 1 3 21 4 K.DGDREVEEEMK.K 39754 537.5706 1609.6901 1609.8424 -0.1523 0 0 34 2 R.TALHLASANGNSEVVK.L

28. P15924|DESP_HUMAN Mass: 334021 Score: 366 Queries matched: 107 emPAI: 0.09 Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10545 577.2558 576.2486 576.3119 -0.0633 0 4 66 8 K.TTLDK.L 19927 424.2410 846.4675 846.4083 0.0592 0 17 1.2 1 K.QSLDDAAK.T 19923 19924 19931 19934 19942 19950 19952 19955 3566 442.2547 882.4948 882.4521 0.0427 0 2 61 3 R.FLSEMLK.S 23011 447.2264 892.4382 892.4654 -0.0272 0 13 2.7 2 R.VQYDLQK.A 23449 451.7250 901.4355 901.5120 -0.0765 0 1 62 7 K.LASLEELK.R 4722 454.2577 906.5009 906.5174 -0.0165 0 15 3.9 1 R.YIELLTR.S 4723 5010 458.7756 915.5366 915.5389 -0.0023 1 4 26 2 R.SLKEQAIK.I 5015 24200 465.7399 929.4652 929.4930 -0.0278 0 21 0.55 1 R.AQIDNLTR.E 24425 471.7570 941.4994 941.5294 -0.0300 0 52 0.00035 1 R.QVQNLVNK.S 24426 24570 476.2337 950.4529 950.4345 0.0184 0 0 58 7 K.AEFQEEAK.R 6503 498.2076 994.4006 994.5560 -0.1554 1 6 34 1 K.QDQKIVHK.G 25894 501.7460 1001.4775 1001.5142 -0.0367 0 38 0.011 1 K.VQEQELTR.L 26430 513.7269 1025.4392 1025.4600 -0.0208 0 6 11 1 K.FGDSNTVMR.F 7589 521.7241 1041.4337 1041.4550 -0.0212 0 (6) 15 2 K.FGDSNTVMR.F 26956 523.2694 1044.5242 1044.4335 0.0907 0 7 11 2 R.DNYQAFCK.W 27125 523.2844 1044.5542 1044.5564 -0.0021 0 9 8 2 R.GIVDSITGQR.L 26967 26980 27653 530.2602 1058.5058 1058.5468 -0.0410 0 24 0.25 1 R.SQLQISNNR.T 28235 537.2642 1072.5138 1072.5513 -0.0375 0 56 0.00015 1 R.GAGSIAGASASPK.E 28285 537.7569 1073.4993 1073.6233 -0.1240 1 13 3 1 R.LPVDIAYKR.G 9053 546.2024 1090.3901 1090.5692 -0.1791 1 2 1.1e+002 8 R.MSQLEVKEK.E 29568 554.2458 1106.4770 1106.5356 -0.0586 1 7 11 5 K.AEFQEEAKR.R 29573 29574 29585 29588 29590 29599 29601 29570 554.2504 1106.4862 1106.5641 -0.0780 1 (1) 45 10 R.MSQLEVKEK.E 29953 561.3005 1120.5864 1120.6240 -0.0376 1 1 44 4 K.VSYVQLKER.C 9901 566.2466 1130.4786 1130.5469 -0.0683 0 2 69 5 R.GIHNSIGDYR.W 10284 570.3136 1138.6127 1138.6597 -0.0471 0 18 1.8 1 R.AELIVQPELK.Y 10270 10275 10286 30804 571.8507 1141.6869 1141.6455 0.0414 1 1 37 5 R.KQQLEVELR.Q 31167 580.2846 1158.5546 1158.6357 -0.0811 1 10 5.5 2 R.RLSSEVEALR.R 31179 580.3054 1158.5963 1158.6357 -0.0393 1 11 4.9 2 R.LSSEVEALRR.Q 31168 31169 31170 31171 31173 31174 31175 3117 31205 580.7387 1159.4628 1159.4968 -0.0339 0 24 0.21 1 K.YQAECSQFK.A 31341 583.2755 1164.5364 1164.5775 -0.0411 0 28 0.072 1 K.IQSQFTDAQK.H 31427 585.7571 1169.4997 1169.5313 -0.0316 0 46 0.0011 1 R.YEVTSGGGGTSR.M 31429 31432 31434 11106 589.8062 1177.5979 1177.6376 -0.0397 1 3 31 1 K.TTIKEISMQK.E 11484 597.8008 1193.5871 1193.6326 -0.0455 1 (2) 28 2 K.TTIKEISMQK.E 32350 601.3048 1200.5951 1200.6350 -0.0399 0 29 0.063 1 R.QLLQEQESVK.Q 32717 610.7692 1219.5238 1219.5680 -0.0443 0 56 0.00014 1 R.ETQSQLETER.S 32714 32715 32716 32718 32719 32720 32721 3272 34004 631.2758 1260.5370 1260.5881 -0.0511 0 53 0.00023 1 K.NQCTQVVQER.E 34005 34209 633.3447 1264.6748 1264.6524 0.0224 1 1 34 3 K.YGDGIQLTRSR.E 12903 636.3366 1270.6587 1270.6993 -0.0406 0 22 0.98 1 R.QLQNIIQATSR.E 34557 34830 642.3307 1282.6469 1282.5976 0.0493 1 16 1.2 2 K.DMLANFRGSEK.Y 2718 430.8744 1289.6013 1289.6575 -0.0563 0 9 6.5 1 K.NTLTQTTENLR.R 2712 2713 2719 2725 2726 2727 2734 35002 2916 434.8743 1301.6010 1301.6840 -0.0831 1 0 44 6 K.VTQLTDRWQR.I 35830 657.8739 1313.7332 1313.7238 0.0094 1 0 41 8 K.RLLQLQEQMR.A 35831 38330 738.3743 1474.7340 1474.8143 -0.0803 1 7 8.6 6 R.FQNSLKELQLQK.Q

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29. Q14525|KT33B_HUMAN Mass: 47325 Score: 334 Queries matched: 68 emPAI: 0.26 Keratin, type I cuticular Ha3-II OS=Homo sapiens GN=KRT33B PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 K.LAADDFR.T 121 16513 16514 16515 16516 16517 16518 16519 123 1 778 412.2223 822.4300 822.4487 -0.0187 0 25 0.45 1 R.LASYLEK.V 17471 25464 494.7666 987.5187 987.5237 -0.0049 0 17 1.2 1 K.TIEELQQK.I 25462 25465 25676 500.2868 998.5591 998.5760 -0.0169 0 24 0.19 1 R.LVVQIDNAK.L 26376 512.7448 1023.4750 1023.4985 -0.0235 0 17 1.1 1 K.YQTEQSLR.Q 26375 26378 32292 599.2715 1196.5284 1196.5495 -0.0212 0 28 0.08 1 R.LECEINTYR.S 2293 425.2852 1272.8337 1272.6674 0.1664 0 6 43 1 R.QLVESDINSLR.R

30. Q15323|K1H1_HUMAN Mass: 48633 Score: 334 Queries matched: 68 emPAI: 0.25 Keratin, type I cuticular Ha1 OS=Homo sapiens GN=KRT31 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 K.LAADDFR.T 121 16513 16514 16515 16516 16517 16518 16519 123 1 778 412.2223 822.4300 822.4487 -0.0187 0 25 0.45 1 R.LASYLEK.V 17471 25464 494.7666 987.5187 987.5237 -0.0049 0 17 1.2 1 K.TIEELQQK.I 25462 25465 25676 500.2868 998.5591 998.5760 -0.0169 0 24 0.19 1 R.LVVQIDNAK.L 9382 552.7928 1103.5710 1103.5896 -0.0186 0 15 1.9 1 R.ILDELTLCK.S 29396 29397 32292 599.2715 1196.5284 1196.5495 -0.0212 0 28 0.08 1 R.LECEINTYR.S 33602 619.8588 1237.7030 1237.6666 0.0364 1 4 18 1 R.TKYQTELSLR.Q

31. O76013|KRT36_HUMAN Mass: 53354 Score: 324 Queries matched: 63 emPAI: 0.14 Keratin, type I cuticular Ha6 OS=Homo sapiens GN=KRT36 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 K.LAADDFR.T 121 16513 16514 16515 16516 16517 16518 16519 123 1 20038 425.7440 849.4735 849.4596 0.0139 0 1 48 6 R.LANYLEK.V 6972 507.2998 1012.5851 1012.5917 -0.0066 0 34 0.061 1 R.LVLQIDNAK.L 9382 552.7928 1103.5710 1103.5896 -0.0186 0 15 1.9 1 R.ILDELTLCK.A 29396 29397 38314 491.9099 1472.7080 1472.7219 -0.0139 1 21 0.38 1 R.QLERENAELESR.I

32. P05783|K1C18_HUMAN Mass: 48029 Score: 323 Queries matched: 94 emPAI: 0.08 Keratin, type I cytoskeletal 18 OS=Homo sapiens GN=KRT18 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13239 655.4512 654.4439 654.3337 0.1103 0 1 38 5 R.EHLEK.K 16550 404.2004 806.3863 806.3923 -0.0060 0 55 0.00019 1 R.LAADDFR.V 121 16513 16514 16515 16516 16517 16518 16519 123 1 4628 452.2504 902.4862 902.4457 0.0405 1 6 33 2 K.NREELDK.Y 29093 547.2643 1092.5141 1092.5563 -0.0422 1 13 2.7 3 R.AQYDELARK.N 29039 29043 29045 29046 29047 29051 29059 29060 9326 552.2442 1102.4738 1102.5731 -0.0993 1 6 36 1 R.VRSLETENR.R 29298 9464 555.1559 1108.2973 1108.4819 -0.1846 0 0 37 4 K.ETMQSLNDR.L 33016 611.3495 1220.6844 1220.6513 0.0331 1 1 43 1 K.LEAEIATYRR.L 41483 628.6311 1882.8715 1883.0000 -0.1285 0 2 20 1 K.GLQAQIASSGLTVEVDAPK.S

33. P07355|ANXA2_HUMAN Mass: 38808 Score: 307 Queries matched: 14 emPAI: 0.32 Annexin A2 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 28628 543.7438 1085.4731 1085.4778 -0.0047 0 8 7.8 3 K.AYTNFDAER.D 29712 556.2746 1110.5346 1110.5458 -0.0112 0 39 0.0064 1 R.QDIAFAYQR.R 29710 9502 9503 9508 33049 611.7947 1221.5748 1221.5877 -0.0129 0 53 0.00025 1 K.TPAQYDASELK.A 33042 33047 33659 622.8027 1243.5909 1243.6156 -0.0247 0 75 1.6e-006 1 R.TNQELQEINR.V 33656 33658 33660 33661

34. Q01546|K22O_HUMAN Mass: 66400 Score: 257 Queries matched: 111 emPAI: 0.46 Keratin, type II cytoskeletal 2 oral OS=Homo sapiens GN=KRT76 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 126 25953 503.2272 1004.4399 1004.4597 -0.0198 0 49 0.00078 1 K.LLEGEECR.M 6832 25946 25947 25948 25949 25950 25951 25952 25 26428 513.7141 1025.4137 1025.4488 -0.0351 0 5 12 2 K.DVDAAFMNK.V 26967 523.2704 1044.5262 1044.5564 -0.0302 0 4 24 8 K.LGELQTTAGR.H 28047 533.7466 1065.4786 1065.5090 -0.0305 1 51 0.00044 1 K.YEDEINKR.T 28043 28045 28046 28048 28049 28050 28051 28052 2 8509 536.3104 1070.6063 1070.6084 -0.0021 1 4 68 5 R.LRAEIENVK.K 8737 541.7932 1081.5718 1081.5920 -0.0203 1 43 0.0025 1 K.FASFIDKVR.F 28512 8735 8736 30402 567.2791 1132.5437 1132.5546 -0.0109 1 51 0.00047 1 R.KLLEGEECR.M 30332 30347 30348 30352 30363 30375 30377 30380 30728 569.2604 1136.5062 1136.5462 -0.0400 0 8 9.2 1 R.TQYEEIAQR.S 31059 578.2551 1154.4957 1154.5278 -0.0320 0 31 0.033 1 R.DYQELMNVK.L 10567 31057 31060 10571 31061 31062 31063 31064 31830 589.7953 1177.5761 1177.5979 -0.0218 0 9 7.8 1 R.TAAENEFVGLK.K 38366 738.8789 1475.7431 1475.7984 -0.0552 1 31 0.04 1 R.FLEQQNKVLETK.W 38363 38365 38367

35. P01023|A2MG_HUMAN Mass: 164614 Score: 227 Queries matched: 18 emPAI: 0.17 Alpha-2-macroglobulin OS=Homo sapiens GN=A2M PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17966 414.7429 827.4712 827.4501 0.0211 0 1 43 6 K.SDIAPVAR.L 22814 442.2793 882.5441 882.5538 -0.0097 0 12 2.8 3 R.DLKPAIVK.V 22922 443.7164 885.4183 885.4345 -0.0162 0 19 0.87 1 K.YGAATFTR.T 23927 463.2634 924.5123 924.5393 -0.0269 0 10 4.3 1 R.TGTHGLLVK.Q 26142 509.2743 1016.5341 1016.5502 -0.0161 1 14 2.8 1 K.SLNEEAVKK.D 26233 509.7949 1017.5753 1017.5859 -0.0105 0 1 52 1 K.ATVLNYLPK.C 9355 552.2964 1102.5782 1102.5982 -0.0200 0 48 0.002 1 R.SSGSLLNNAIK.G 29358 29828 558.8013 1115.5881 1115.5975 -0.0095 0 24 0.22 1 R.QTVSWAVTPK.S 9656 560.7904 1119.5663 1119.6288 -0.0625 0 2 31 1 K.SIYKPGQTVK.F 30675 567.7905 1133.5665 1133.5750 -0.0085 0 54 0.00023 1 R.SASNMAIVDVK.M 33855 628.3243 1254.6341 1254.6357 -0.0016 0 44 0.0019 1 K.AIGYLNTGYQR.Q 33854 12564 630.2787 1258.5428 1258.5652 -0.0224 0 (28) 0.3 1 R.VGFYESDVMGR.G 34563 636.8283 1271.6420 1271.6656 -0.0236 0 80 4.4e-007 1 R.VTAAPQSVCALR.A 34564 34604 638.2815 1274.5484 1274.5602 -0.0118 0 41 0.0033 1 R.VGFYESDVM GR.G 37286 697.8384 1393.6623 1393.6725 -0.0102 0 57 9.8e-005 1 K.NEDSLVFVQTDK.S

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36. P12035|K2C3_HUMAN Mass: 64636 Score: 215 Queries matched: 124 emPAI: 0.48 Keratin, type II cytoskeletal 3 OS=Homo sapiens GN=KRT3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 859 412.2350 822.4553 822.4018 0.0536 1 2 94 1 -.MSRQASK.T 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 12 7587 521.7203 1041.4260 1041.4437 -0.0176 0 13 2.9 1 K.DVDSAYMNK.V 7580 7581 7582 26878 7583 7584 7585 26879 7586 7 26967 523.2704 1044.5262 1044.5564 -0.0302 0 4 24 8 K.LGELQTTAGR.H 28047 533.7466 1065.4786 1065.5090 -0.0305 1 51 0.00044 1 K.YEDEINKR.T 28043 28045 28046 28048 28049 28050 28051 28052 8737 541.7932 1081.5718 1081.5920 -0.0203 1 43 0.0025 1 K.FASFIDKVR.F 28512 8735 8736 29064 547.2550 1092.4955 1092.5200 -0.0245 0 28 0.082 2 R.AQYEDIAQR.S 29039 29043 29045 29046 29047 29051 29058 2905 31059 578.2551 1154.4957 1154.5278 -0.0320 0 31 0.033 1 R.DYQELMNVK.L 10567 31057 31060 10571 31061 31062 31063 31064 31436 585.7665 1169.5184 1169.5387 -0.0202 1 18 0.71 1 K.KDVDSAYMNK.V 31428 31430 31431 31433 31435 31437 31438 3143 33054 611.8007 1221.5869 1221.6241 -0.0372 0 61 4.4e-005 1 R.TAAENEFVTLK.K 33055 33059 33060 36417 675.8542 1349.6938 1349.7191 -0.0253 1 48 0.00085 1 R.TAAENEFVTLKK.D 38366 738.8789 1475.7431 1475.7984 -0.0552 1 31 0.04 1 R.FLEQQNKVLETK.W 38363 38365 38367

37. P63104|1433Z_HUMAN Mass: 27899 Score: 209 Queries matched: 11 emPAI: 0.67 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23550 454.2559 906.4973 906.5174 -0.0202 0 34 0.023 1 R.NLLSVAYK.N 23551 23552 33786 626.7937 1251.5728 1251.6394 -0.0666 1 13 2.1 3 K.KEMQPTHPIR.L 33781 33783 34684 427.2190 1278.6352 1278.6456 -0.0103 1 41 0.0041 1 R.YLAEVAAGDDKK.G 35383 652.8287 1303.6427 1303.6772 -0.0344 0 38 0.0074 1 K.FLIPNASQAESK.V 35384 39428 774.8451 1547.6756 1547.7063 -0.0307 0 107 8.9e-010 1 K.SVTEQGAELSNEER.N 39427

38. P04075|ALDOA_HUMAN Mass: 39851 Score: 177 Queries matched: 11 emPAI: 0.43 Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16478 401.2395 800.4645 800.4756 -0.0111 0 44 0.0028 1 R.ALQASALK.A 16474 16476 16477 24406 470.7328 939.4510 939.4774 -0.0264 0 7 11 1 K.ELSDIAHR.I 29102 547.2848 1092.5551 1092.5563 -0.0012 1 29 0.064 1 K.AAQEEYVKR.A 30318 566.7876 1131.5606 1131.5706 -0.0100 0 36 0.014 1 R.ALANSLACQGK.Y 30316 36122 666.8410 1331.6674 1331.6932 -0.0258 0 67 9.6e-006 1 K.GILAADESTGSIAK.R 36123 40331 549.5962 1645.7667 1645.8019 -0.0353 1 8 5.4 2 R.LQSIGTENTEENRR.F

39. P60174|TPIS_HUMAN Mass: 26938 Score: 169 Queries matched: 8 emPAI: 1.20 Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20037 425.7256 849.4367 849.4596 -0.0229 0 36 0.015 1 K.VVFEQTK.V 30730 569.2800 1136.5455 1136.5648 -0.0193 0 48 0.00077 1 K.IAVAAQNCYK.V 30729 33284 617.7885 1233.5625 1233.5949 -0.0324 0 95 1.6e-008 1 K.SNVSDAVAQSTR.I 36025 663.8224 1325.6302 1325.6649 -0.0347 0 54 0.00018 1 R.IIYGGSVTGATCK.E 38243 733.8327 1465.6508 1465.7161 -0.0653 0 30 0.035 1 K.TATPQQAQEVHEK.L 38244 38245

40. A8MT79|ZAGL1_HUMAN Mass: 23080 Score: 168 Queries matched: 22 emPAI: 0.17 Putative zinc-alpha-2-glycoprotein-like 1 OS=Homo sapiens PE=5 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 30188 564.2794 1126.5443 1126.5618 -0.0176 0 76 1.3e-006 1 R.AGEVQEPELR.G 30154 30156 30157 30161 30165 30166 30168 3017

Proteins matching the same set of peptides: P25311|ZA2G_HUMAN Mass: 34079 Score: 168 Queries matched: 22 Zinc-alpha-2-glycoprotein OS=Homo sapiens GN=AZGP1 PE=1 SV=1

41. P12036|NFH_HUMAN Mass: 112639 Score: 165 Queries matched: 53 emPAI: 0.07 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12567 630.3451 629.3379 629.3384 -0.0006 0 1 1.5e+002 1 K.SPAEVK.S 16504 403.7344 805.4543 805.3752 0.0791 0 5 20 3 K.VNTDAMR.S 16510 22473 437.2149 872.4152 872.4239 -0.0087 1 6 16 6 K.EPDDAKAK.E 5093 460.2363 918.4581 918.4294 0.0287 1 8 47 1 K.EAKEEEGK.E 25953 503.2272 1004.4399 1004.4597 -0.0198 0 49 0.00078 1 K.LLEGEECR.I 6832 25946 25947 25948 25949 25950 25951 25952 2 30402 567.2791 1132.5437 1132.5546 -0.0109 1 51 0.00047 1 R.KLLEGEECR.I 30332 30347 30348 30352 30363 30375 30377 30380 31305 582.7551 1163.4956 1163.5782 -0.0826 0 3 27 1 R.TSVSSVSASPSR.F 32717 610.7692 1219.5238 1219.6660 -0.1422 1 3 24 6 R.TTELEALKSTK.D 32732 5414 469.2808 1404.8207 1404.7031 0.1176 1 2 75 2 R.LSEAAKVNTDAMR.S 37928 719.2907 1436.5669 1436.6433 -0.0764 0 8 4.7 1 R.SAAGSSSGFHSWTR.T 37927 39181 763.8384 1525.6622 1525.7988 -0.1365 1 2 25 10 K.SPVKEEEKPQEVK.V

42. P06396|GELS_HUMAN Mass: 86043 Score: 137 Queries matched: 19 emPAI: 0.29 Gelsolin OS=Homo sapiens GN=GSN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19935 424.2444 846.4743 846.5076 -0.0332 1 6 16 4 R.LFQVKGR.R 22744 441.7249 881.4353 881.4494 -0.0141 0 28 0.078 1 K.TASDFITK.M 22745 22746 3691 444.2444 886.4743 886.4872 -0.0129 0 45 0.0083 1 K.TGAQELLR.V 3688 3689 3692 23766 457.2850 912.5555 912.5757 -0.0202 1 19 0.72 1 R.RTPITVVK.Q 25658 500.2174 998.4202 998.4893 -0.0691 0 0 52 3 R.GASQAGAPQGR.V 8605 537.7477 1073.4809 1073.5101 -0.0293 0 3 31 8 R.EGGQTAPASTR.L 28289 28419 539.7514 1077.4882 1077.5091 -0.0208 0 32 0.033 1 R.YIETDPANR.D 34606 638.3514 1274.6883 1274.7095 -0.0212 0 43 0.0024 1 K.HVVPNEVVVQR.L 35893 660.3446 1318.6745 1318.6881 -0.0135 0 63 2.4e-005 1 K.AGALNSNDAFVLK.T 35891 13290 36381 450.5480 1348.6222 1348.6371 -0.0149 1 4 23 1 R.YIETDPANRDR.R 41347 915.4698 1828.9251 1828.9571 -0.0319 0 38 0.0048 1 K.QTQVSVLPEGGETPLFK.Q

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43. P52566|GDIR2_HUMAN Mass: 23031 Score: 136 Queries matched: 6 emPAI: 0.36 Rho GDP-dissociation inhibitor 2 OS=Homo sapiens GN=ARHGDIB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2469 428.2435 854.4724 854.4974 -0.0250 0 43 0.0058 1 K.APNVVVTR.L 2474 2475 4743 454.7502 907.4857 907.3957 0.0901 0 2 29 1 K.ELQEMDK.D 35792 656.3345 1310.6545 1310.7082 -0.0537 0 68 8.2e-006 1 K.TLLGDGPVVTDPK.A 35793

44. P04406|G3P_HUMAN Mass: 36201 Score: 131 Queries matched: 40 emPAI: 0.35 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16492 403.2098 804.4050 804.4243 -0.0193 0 18 1.2 1 K.VGVNGFGR.I 16753 406.2043 810.3940 810.4058 -0.0118 0 27 0.1 1 K.LTGMAFR.V 20846 435.2342 868.4538 868.5018 -0.0480 0 8 7.4 1 K.VIPELNGK.L 2959 2961 2966 20824 20829 20831 20833 20834 208 27968 533.2451 1064.4756 1064.5839 -0.1083 1 10 5.4 4 K.AGAHLQGGAKR.V 27956 31275 582.3116 1162.6086 1162.6458 -0.0372 1 3 26 1 R.LVTRAAFNSGK.V 32661 609.3415 1216.6684 1216.5944 0.0740 0 4 18 4 R.VVDLMAHMASK.E 37595 706.3760 1410.7375 1410.7831 -0.0456 0 44 0.0017 1 R.GALQNIIPASTGAAK.A 37594 37596 37598 39309 765.8891 1529.7636 1529.7872 -0.0236 0 67 7.2e-006 1 R.VPTANVSVVDLTCR.L

45. O00391|QSOX1_HUMAN Mass: 83324 Score: 130 Queries matched: 13 emPAI: 0.24 Sulfhydryl oxidase 1 OS=Homo sapiens GN=QSOX1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24480 473.2544 944.4942 944.5080 -0.0138 0 42 0.0047 1 R.FPVLEGQR.L 5576 24505 473.7461 945.4777 945.4953 -0.0176 0 27 0.13 1 R.VPVLMESR.S 24506 29792 557.7997 1113.5847 1113.6142 -0.0295 0 43 0.0026 1 R.VLNTEANVVR.K 29793 29794 29795 30771 570.3001 1138.5856 1138.5982 -0.0126 0 17 0.95 1 R.EVALDLSQHK.G 34556 635.8515 1269.6884 1269.7153 -0.0269 1 21 0.37 1 R.RVLNTEANVVR.K 36605 678.8293 1355.6440 1355.6721 -0.0281 0 57 8.4e-005 1 R.LAGAPSEDPQFPK.V 36606 47234 520.1222 3114.6895 3114.4903 0.1992 1 1 9.4 1 R.ELCSACHNERLDVPVWDVEATLNFLK.A

46. P05090|APOD_HUMAN Mass: 21547 Score: 128 Queries matched: 14 emPAI: 0.39 Apolipoprotein D OS=Homo sapiens GN=APOD PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22379 436.2453 870.4761 870.4923 -0.0162 0 43 0.0034 1 K.VLNQELR.A 3247 22368 22369 22370 22375 22376 22378 22381 22 35506 654.7882 1307.5618 1307.5850 -0.0232 0 67 9.2e-006 1 K.MTVTDQVNCPK.L 35504 35505

47. Q9UBR2|CATZ_HUMAN Mass: 34530 Score: 128 Queries matched: 27 emPAI: 0.23 Cathepsin Z OS=Homo sapiens GN=CTSZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 26003 505.7444 1009.4742 1009.4829 -0.0086 0 55 0.00016 1 R.VGDYGSLSGR.E 26001 26004 29719 556.2804 1110.5462 1110.5921 -0.0459 1 21 0.36 2 R.IVTSTYKDGK.G 9501 29711 9504 29713 9506 9507 29714 29715 29 35531 654.8181 1307.6217 1307.6470 -0.0253 0 59 5.1e-005 1 R.NVDGVNYASITR.N

48. P01876|IGHA1_HUMAN Mass: 38486 Score: 124 Queries matched: 14 emPAI: 0.32 Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17241 409.7013 817.3880 817.3970 -0.0090 0 42 0.0052 1 R.VAAEDWK.K 24245 466.2658 930.5171 930.5386 -0.0215 0 42 0.004 1 K.TPLTATLSK.S 24236 24237 5317 24238 5318 24240 24242 24243 2 36946 688.3006 1374.5867 1374.6126 -0.0258 0 79 5.5e-007 1 K.TFTCTAAYPESK.T 36945

49. P10451|OSTP_HUMAN Mass: 35572 Score: 117 Queries matched: 5 emPAI: 0.11 Osteopontin OS=Homo sapiens GN=SPP1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7501 519.2719 1036.5293 1036.4309 0.0984 0 2 1.5e+002 1 K.QADSGSSEEK.Q 37082 694.3149 1386.6153 1386.6263 -0.0109 0 49 0.00056 1 R.ISHELDSASSEVN.- 37079 37080 37081

50. P25774|CATS_HUMAN Mass: 38099 Score: 115 Queries matched: 11 emPAI: 0.33 Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23412 450.7325 899.4505 899.4613 -0.0108 0 42 0.0033 1 R.VPSQWQR.N 23413 23414 24699 478.7378 955.4611 955.5087 -0.0476 0 45 0.0017 1 K.GPVSVGVDAR.H 24700 24701 25641 499.7349 997.4553 997.4869 -0.0316 0 26 0.12 1 K.YTELPYGR.E 32582 608.2603 1214.5061 1214.5455 -0.0394 0 63 2.8e-005 1 K.GIDSDASYPYK.A 32584 32585 41778 501.7916 2003.1374 2003.0378 0.0996 1 2 16 3 K.GPVSVGVDARHPSFFLYR.S

51. Q13231|CHIT1_HUMAN Mass: 52219 Score: 111 Queries matched: 7 emPAI: 0.23 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25895 501.7464 1001.4783 1001.4930 -0.0147 0 15 2.1 1 K.ADGLYPNPR.E 7441 518.2763 1034.5380 1034.5509 -0.0128 0 21 1.7 1 R.QTFVNSAIR.F 29797 558.2854 1114.5563 1114.5771 -0.0208 0 14 1.9 1 K.VTGHNSPLYK.R 31457 586.2756 1170.5366 1170.5517 -0.0151 0 44 0.0024 1 R.SFTLASSSDTR.V 33852 628.2807 1254.5468 1254.5663 -0.0195 0 56 0.00012 1 K.FTDMVATANNR.Q 38087 722.8585 1443.7025 1443.7358 -0.0333 0 60 4.3e-005 1 R.VGAPATGSGTPGPFTK.E 42318 538.5526 2150.1812 2150.1057 0.0755 0 2 15 1 R.SVAWAGFMVLLMIPWGSAAK.L

52. P07737|PROF1_HUMAN Mass: 15216 Score: 110 Queries matched: 2 emPAI: 0.26 Profilin-1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 36980 690.3461 1378.6777 1378.7093 -0.0316 0 74 1.8e-006 1 K.STGGAPTFNVTVTK.T 36979

53. P08238|HS90B_HUMAN Mass: 83554 Score: 109 Queries matched: 12 emPAI: 0.14 Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1378 415.2566 828.4986 828.5221 -0.0236 0 16 2.9 2 R.ALLFIPR.R 26926 523.2660 1044.5174 1044.5927 -0.0753 1 8 8.5 6 K.VEKVTISNR.L 26911 26988 27009 27013 27028 27099 27130 31022 576.2740 1150.5333 1150.5506 -0.0172 0 30 0.049 1 K.YIDQEELNK.T 33646 621.8424 1241.6702 1241.6979 -0.0277 0 68 8.1e-006 1 K.ADLINNLGTIAK.S 39059 757.3717 1512.7289 1512.7784 -0.0495 0 63 2.4e-005 1 R.GVVDSEDLPLNISR.E

54. P07900|HS90A_HUMAN Mass: 85006 Score: 109 Queries matched: 6 emPAI: 0.14 Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 31022 576.2740 1150.5333 1150.5506 -0.0172 0 30 0.049 1 K.YIDQEELNK.T 32720 610.7783 1219.5421 1219.4849 0.0572 0 1 40 3 R.DNSTMGYMAAK.K 12394 618.2949 1234.5751 1234.5942 -0.0191 0 16 4.2 1 K.DQVANSAFVER.L 33646 621.8424 1241.6702 1241.6979 -0.0277 0 68 8.1e-006 1 K.ADLINNLGTIAK.S 35148 432.8733 1295.5982 1295.6582 -0.0600 1 2 29 1 K.LGIHEDSQNRK.K 39059 757.3717 1512.7289 1512.7784 -0.0495 0 63 2.4e-005 1 R.GVVDSEDLPLNISR.E

55. P31025|LCN1_HUMAN Mass: 19409 Score: 107 Queries matched: 4 emPAI: 0.44 Lipocalin-1 OS=Homo sapiens GN=LCN1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23008 446.7443 891.4741 891.4848 -0.0107 0 26 0.16 1 K.VTMLISGR.C 3806 31947 593.3293 1184.6441 1184.6765 -0.0324 0 75 1.6e-006 1 R.GLSTESILIPR.Q 31948

56. Q8N1N4|K2C78_HUMAN Mass: 57629 Score: 102 Queries matched: 22 emPAI: 0.21 Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25953 503.2272 1004.4399 1004.4597 -0.0198 0 49 0.00078 1 R.LLEGEECR.M 6832 25946 25947 25948 25949 25950 25951 25952 2 31222 581.2750 1160.5354 1160.5608 -0.0253 1 41 0.0039 1 R.RLLEGEECR.M 34959 645.2856 1288.5567 1288.6637 -0.1070 1 5 15 5 R.GSTWGSGGRLGVR.F 34965 13994 692.3474 1382.6803 1382.6249 0.0554 0 0 1.4e+002 3 R.SLNSFGGCLEGSR.G 38366 738.8789 1475.7431 1475.7984 -0.0552 1 31 0.04 1 R.FLEQQNKVLETK.W 38363 38365 38367

57. P62988|UBIQ_HUMAN Mass: 8560 Score: 101 Queries matched: 25 emPAI: 1.18 Ubiquitin OS=Homo sapiens GN=RPS27A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 28501 541.2737 1080.5328 1080.5451 -0.0123 0 49 0.00068 1 R.TLSDYNIQK.E 28484 28487 28488 28489 28490 28491 28492 28493 39161 508.5937 1522.7593 1522.7740 -0.0147 1 13 1.8 1 K.IQDKEGIPPDQQR.L 39159 39160 39162 39163 41123 894.4503 1786.8860 1786.9200 -0.0340 0 54 0.00014 1 K.TITLEVEPSDTIENVK.A

58. P14618|KPYM_HUMAN Mass: 58470 Score: 101 Queries matched: 7 emPAI: 0.20 Pyruvate kinase isozymes M1/M2 OS=Homo sapiens GN=PKM2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18334 420.7600 839.5055 839.5229 -0.0173 0 3 21 7 R.APIIAVTR.N 26258 510.2588 1018.5030 1018.5083 -0.0053 0 27 0.14 1 K.GDYPLEAVR.M 30794 571.2889 1140.5632 1140.6026 -0.0394 0 15 1.6 1 R.GDLGIEIPAEK.V 11528 599.3217 1196.6289 1196.6401 -0.0111 0 48 0.0018 1 R.LDIDSPPITAR.N 11531 34513 634.3208 1266.6271 1266.6060 0.0211 1 4 20 9 K.EM IKSGMNVAR.L 13816 680.3521 1358.6896 1358.6976 -0.0080 0 48 0.0024 1 R.NTGIICTIGPASR.S

59. P17900|SAP3_HUMAN Mass: 21281 Score: 100 Queries matched: 10 emPAI: 0.64 Ganglioside GM2 activator OS=Homo sapiens GN=GM2A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 277 408.2319 814.4491 814.4800 -0.0309 0 33 0.071 1 K.VDLVLEK.E 17008 17009 25966 503.7576 1005.5006 1005.5342 -0.0336 0 44 0.0022 1 R.IESVLSSSGK.R 25964 25965 25967 31250 581.8018 1161.5891 1161.6353 -0.0463 1 40 0.0054 1 R.IESVLSSSGKR.L 31246 31251

60. P06733|ENOA_HUMAN Mass: 47481 Score: 97 Queries matched: 9 emPAI: 0.26 Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16501 403.7157 805.4169 805.4446 -0.0277 0 0 63 7 K.YNQLLR.I 23409 450.2752 898.5358 898.5488 -0.0130 0 31 0.039 1 K.TIAPALVSK.K 23402 23407 23474 452.7337 903.4529 903.4549 -0.0020 0 46 0.0015 1 R.IEEELGSK.A 9343 552.2846 1102.5546 1102.5870 -0.0323 1 4 58 1 R.IEEELGSKAK.F 30817 572.3094 1142.6043 1142.6084 -0.0041 0 55 0.00017 1 R.IGAEVYHNLK.N 30816 37535 703.8584 1405.7023 1405.7089 -0.0066 0 21 0.37 1 R.GNPTVEVDLFTSK.G

61. Q5VSK2|MRC1L_HUMAN Mass: 168904 Score: 96 Queries matched: 10 emPAI: 0.07 Macrophage mannose receptor 1-like protein 1 OS=Homo sapiens GN=MRC1L1 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11155 590.2944 589.2871 589.3184 -0.0312 1 0 83 3 K.ADTRK.M 11156 11713 606.3507 605.3434 605.2922 0.0512 0 2 44 1 K.GYPGGR.R 11715 11721 24904 481.2336 960.4527 960.4699 -0.0172 0 34 0.027 1 K.SCVSLNPGK.N 32193 597.8451 1193.6756 1193.5353 0.1403 0 0 47 1 R.YTNWAADEPK.L 32560 607.8098 1213.6051 1213.6190 -0.0139 0 57 0.00011 1 R.SQGPEIVEVEK.G 35256 650.2903 1298.5661 1298.5925 -0.0264 0 54 0.00017 1 K.IYGTTDNLCSR.G 14266 738.8686 1475.7226 1475.7442 -0.0216 1 6 11 1 K.WECKNDTLLGIK.G

Proteins matching the same set of peptides: P22897|MRC1_HUMAN Mass: 168870 Score: 96 Queries matched: 10 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1

62. P07195|LDHB_HUMAN Mass: 36900 Score: 93 Queries matched: 14 emPAI: 0.21

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L-lactate dehydrogenase B chain OS=Homo sapiens GN=LDHB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4958 457.2933 912.5721 912.5757 -0.0036 0 11 9.4 3 K.IVVVTAGVR.Q 4886 23721 23740 23749 24861 480.2697 958.5249 958.5447 -0.0198 0 39 0.0084 1 R.GLTSVINQK.L 24859 24863 24865 33711 624.7948 1247.5750 1247.5928 -0.0178 0 52 0.00029 1 R.VIGSGCNLDSAR.F 33707 33708 33709 33710

63. P05107|ITB2_HUMAN Mass: 87976 Score: 91 Queries matched: 9 emPAI: 0.18 Integrin beta-2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16790 407.2464 812.4783 812.5007 -0.0225 0 32 0.035 1 K.LTEIIPK.S 3307 436.3392 870.6639 870.5287 0.1352 1 2 55 2 K.KLGGDLLR.A 3271 3273 3312 6000 485.2530 968.4915 968.4968 -0.0052 0 38 0.021 1 R.IGFGSFVDK.T 30147 563.8055 1125.5964 1125.6142 -0.0178 0 55 0.00016 1 K.LGAILTPNDGR.C 31021 576.2639 1150.5132 1150.5230 -0.0098 0 3 28 1 K.ECQPPFAFR.H 38514 741.8802 1481.7458 1481.7878 -0.0420 0 41 0.0028 1 R.VFLDHNALPDTLK.V

64. O43933|PEX1_HUMAN Mass: 143804 Score: 85 Queries matched: 50 emPAI: 0.05 Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4633 452.2649 902.5151 902.5073 0.0079 1 5 44 5 K.LETKDGLK.E 25006 484.7287 967.4429 967.6178 -0.1749 1 12 2.9 1 K.LLIQPKTR.R 28002 533.2539 1064.4933 1064.5358 -0.0425 1 41 0.0045 1 K.GMMKELQTK.Q 27952 27954 27956 27959 27961 27962 27968 2796 28345 538.2589 1074.5033 1074.5015 0.0017 0 1 42 6 K.QMSEPLDQK.K 28461 541.2257 1080.4369 1080.5307 -0.0938 1 (37) 0.0094 2 K.GMMKELQTK.Q 28466 28467 28468 28469 28470 28471 28473 28474 28647 544.2708 1086.5270 1086.6219 -0.0949 0 5 18 1 R.QLMSLVAGLR.N 29046 547.2497 1092.4849 1092.5564 -0.0714 0 5 16 4 K.YIGASEQAVR.D 29082 29096 29314 552.2749 1102.5353 1102.6169 -0.0816 0 (2) 39 5 R.QLMSLVAGLR.N 29317 11518 599.2526 1196.4906 1196.6336 -0.1430 0 4 45 4 R.LNIEMHAVVR.I 204 405.2245 1212.6516 1212.6186 0.0330 1 1 1.6e+002 4 R.DCFLHLPRR.L 36764 683.7317 1365.4489 1365.6459 -0.1970 0 3 5.1 1 K.NQSGTMFRPGQK.V 6325 493.2842 1476.8309 1476.6490 0.1819 0 0 1.6e+002 3 K.CVYCPPPDQVSR.L 39216 510.2815 1527.8226 1527.8158 0.0068 1 7 7.4 1 R.DFTVLVDRAIHSR.L 10731 584.2751 1749.8035 1749.8832 -0.0797 1 11 9.5 1 K.NQSGTMFRPGQKVTLA.-

65. P06703|S10A6_HUMAN Mass: 10230 Score: 84 Queries matched: 9 emPAI: 0.39 Protein S100-A6 OS=Homo sapiens GN=S100A6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23547 454.2104 906.4063 906.4117 -0.0054 0 20 0.57 1 R.LMEDLDR.N 23548 23780 458.2441 914.4736 914.4821 -0.0085 0 59 8e-005 1 K.LQDAEIAR.L 23778 23779 23781 23783 6593 500.7816 999.5486 999.5964 -0.0478 1 6 14 1 K.ELKELIQK.E 6598

66. P04083|ANXA1_HUMAN Mass: 38918 Score: 82 Queries matched: 10 emPAI: 0.10 Annexin A1 OS=Homo sapiens GN=ANXA1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13599 674.3612 673.3540 673.3759 -0.0219 1 2 60 2 R.EELKR.D 1377 415.2555 828.4965 828.5069 -0.0104 0 14 4.3 1 R.NALLSLAK.G 23560 454.7243 907.4340 907.4399 -0.0059 0 17 0.97 1 R.ALYEAGER.R 5023 458.7844 915.5543 915.4848 0.0696 0 0 60 1 K.ILVALCGGN.- 23808 460.2058 918.3971 918.5035 -0.1064 1 4 23 3 R.SYPQLRR.V 27929 532.7937 1063.5729 1063.5410 0.0319 1 7 12 7 R.ALYEAGERR.K 27935 34060 631.7953 1261.5761 1261.5939 -0.0178 0 53 0.00026 1 K.TPAQFDADELR.A 34025 34053

67. P01591|IGJ_HUMAN Mass: 18543 Score: 79 Queries matched: 2 emPAI: 0.21 Immunoglobulin J chain OS=Homo sapiens GN=IGJ PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16471 400.7404 799.4662 799.4803 -0.0142 0 26 0.15 1 R.IVLVDNK.C 37139 695.3011 1388.5877 1388.6055 -0.0179 0 79 5.2e-007 1 R.SSEDPNEDIVER.N

68. P00338|LDHA_HUMAN Mass: 36950 Score: 76 Queries matched: 15 emPAI: 0.10 L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13058 648.3640 647.3567 647.3643 -0.0076 0 0 84 1 K.ISGFPK.N 4961 457.3000 912.5855 912.5756 0.0098 0 22 0.61 1 K.LVIITAGAR.Q 23667 23742 4960 30671 567.7697 1133.5248 1133.5564 -0.0316 0 17 1 2 K.VTLTSEEEAR.L 30663 30666 30669 30674 33711 624.7948 1247.5750 1247.5928 -0.0178 0 52 0.00029 1 R.VIGSGCNLDSAR.F 33707 33708 33709 33710

69. Q6ZMR3|LDH6A_HUMAN Mass: 36826 Score: 76 Queries matched: 12 emPAI: 0.10 L-lactate dehydrogenase A-like 6A OS=Homo sapiens GN=LDHAL6A PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13058 648.3640 647.3567 647.3643 -0.0076 0 0 84 1 K.LSGFPK.N 33711 624.7948 1247.5750 1247.5928 -0.0178 0 52 0.00029 1 R.VIGSGCNLDSAR.F 33707 33708 33709 33710 37555 705.3139 1408.6133 1408.6735 -0.0602 1 9 5.2 1 K.DPEQWENVHKK.V 37550 37553 37556 37557 45912 458.7468 2746.4373 2746.4687 -0.0314 1 8 2.7 1 K.MPNIVSSKDYLVTANSNLVIITAGAR.Q

70. Q9H299|SH3L3_HUMAN Mass: 10488 Score: 75 Queries matched: 9 emPAI: 0.38 SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 27537 528.7555 1055.4964 1055.5248 -0.0283 0 49 0.00074 1 R.VYSTSVTGSR.E 27538 27539 27540 27541 27542 27543 32372 401.2287 1200.6643 1200.5921 0.0722 1 8 7.4 2 R.DEMRALAGNPK.A 32357

71. P02787|TRFE_HUMAN Mass: 79280 Score: 75 Queries matched: 33 emPAI: 0.15 Serotransferrin OS=Homo sapiens GN=TF PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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25277 489.7296 977.4447 977.4818 -0.0371 0 34 0.021 1 K.DGAGDVAFVK.H 30087 563.2644 1124.5143 1124.6124 -0.0981 1 13 2.6 4 K.EACVHKILR.Q 30058 30060 30061 30062 30064 30066 30070 30072 32491 606.2689 1210.5233 1210.5401 -0.0167 0 50 0.00039 1 K.DSGFQMNQLR.G 33720 625.3064 1248.5982 1248.5986 -0.0004 0 21 0.4 1 K.SASDLTWDNLK.G 2354 426.2425 1275.7056 1275.6248 0.0808 0 5 35 3 K.EFQLFSSPHGK.D 2332 2361 2362 35962 441.8863 1322.6371 1322.6401 -0.0030 1 1 36 8 K.KDSGFQMNQLR.G 37632 708.3442 1414.6738 1414.7126 -0.0388 0 37 0.0093 1 K.SVIPSDGPSVACVK.K 39595 789.3075 1576.6004 1576.6504 -0.0500 0 15 0.76 1 R.FDEFFSEGCAPGSK.K

72. Q9NSB2|KRT84_HUMAN Mass: 65938 Score: 74 Queries matched: 40 emPAI: 0.25 Keratin, type II cuticular Hb4 OS=Homo sapiens GN=KRT84 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 12 24257 466.7308 931.4471 931.4610 -0.0139 0 34 0.025 1 R.LLEGEESR.L 24250 24251 24252 24253 24254 24255 24256 24258 26428 513.7141 1025.4137 1025.4488 -0.0351 0 5 12 2 K.DVDAAFMNK.S 8737 541.7932 1081.5718 1081.5920 -0.0203 1 43 0.0025 1 K.FASFIDKVR.F 28512 8735 8736 28654 544.7339 1087.4533 1087.5621 -0.1088 1 8 10 1 R.RLLEGEESR.L 204 405.2245 1212.6516 1212.6139 0.0377 0 2 1.3e+002 1 R.SVITFGSYSPR.I 11844 13812 679.8631 1357.7116 1357.7202 -0.0085 0 34 0.02 1 R.VAPATGDLLSTGTR.S 36625

73. Q7Z794|K2C1B_HUMAN Mass: 61935 Score: 71 Queries matched: 54 emPAI: 0.12 Keratin, type II cytoskeletal 1b OS=Homo sapiens GN=KRT77 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7672 523.1315 522.1242 522.2551 -0.1308 0 1 36 1 R.GFGSR.S 17938 414.2155 826.4164 826.4225 -0.0061 0 36 0.012 1 K.FASFIDK.V 1262 17918 1263 1264 1265 1266 1267 1268 17931 126 25879 501.2894 1000.5643 1000.5553 0.0090 0 5 20 1 R.LQAEISNVK.K 27741 530.7839 1059.5531 1059.5196 0.0335 0 8 11 6 R.QLLEGEESR.M 8261 28047 533.7466 1065.4786 1065.5090 -0.0305 1 51 0.00044 1 K.YEDEINKR.T 28043 28045 28046 28048 28049 28050 28051 28052 2 9373 552.7706 1103.5267 1103.5645 -0.0378 0 0 52 8 R.EQIMVLNNK.F 36145 668.8417 1335.6689 1335.7034 -0.0345 1 2 26 5 R.TGSENDFVVLKK.D 36157

74. P01842|LAC_HUMAN Mass: 11401 Score: 70 Queries matched: 2 emPAI: 0.82 Ig lambda chain C regions OS=Homo sapiens GN=IGLC1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 40545 837.9230 1673.8314 1673.8472 -0.0158 1 60 3.9e-005 1 K.ADSSPVKAGVETTTPSK.Q 40753 571.2480 1710.7222 1710.7519 -0.0297 0 28 0.044 1 R.SYSCQVTHEGSTVEK.T

75. P61769|B2MG_HUMAN Mass: 13820 Score: 70 Queries matched: 6 emPAI: 0.28 Beta-2-microglobulin OS=Homo sapiens GN=B2M PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 30008 561.8140 1121.6134 1121.6193 -0.0059 0 37 0.011 1 R.VNHVTLSQPK.I 29999 30004 30005 30006 30007

76. Q5T749|KPRP_HUMAN Mass: 67172 Score: 68 Queries matched: 20 emPAI: 0.11 Keratinocyte proline-rich protein OS=Homo sapiens GN=KPRP PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24972 483.2300 964.4455 964.4614 -0.0159 0 20 0.63 1 R.SEPIYNSR.C 24964 24965 5951 24967 24969 24973 24974 24977 249 32698 609.7848 1217.5549 1217.5533 0.0017 0 38 0.0088 1 R.IEISSPCCPR.Q 32690 32691 32692 32693 32694 32695 32696 32697 38927 500.2561 1497.7465 1497.7358 0.0107 1 8 6.6 1 R.RLDQCPESPLQR.C

77. P09382|LEG1_HUMAN Mass: 15048 Score: 67 Queries matched: 3 emPAI: 0.99 Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5988 484.7244 967.4343 967.4651 -0.0307 0 20 0.44 1 K.LPDGYEFK.F 26868 521.2730 1040.5315 1040.5614 -0.0300 1 38 0.0071 1 R.VRGEVAPDAK.S 28381 538.7259 1075.4372 1075.4683 -0.0311 0 61 4.3e-005 1 K.DGGAWGTEQR.E

78. P62942|FKB1A_HUMAN Mass: 12000 Score: 66 Queries matched: 2 emPAI: 0.33 Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens GN=FKBP1A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12188 611.3395 610.3322 610.3149 0.0173 0 10 3.6 1 K.FM LGK.Q 35829 657.8202 1313.6259 1313.6576 -0.0316 0 66 1e-005 1 M.GVQVETISPGDGR.T

79. P12814|ACTN1_HUMAN Mass: 103563 Score: 66 Queries matched: 9 emPAI: 0.04 Alpha-actinin-1 OS=Homo sapiens GN=ACTN1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3786 446.2340 890.4535 890.4644 -0.0108 1 6 66 3 K.EAM LRQK.D 30339 567.2560 1132.4975 1132.5659 -0.0683 1 8 7.7 10 K.AETAANRICK.V 30325 30329 30361 30374 37072 693.8325 1385.6505 1385.7667 -0.1162 0 14 2 1 R.VGWEQLLTTIAR.T 37073 37846 715.3724 1428.7302 1428.7572 -0.0271 0 66 1e-005 1 R.TINEVENQILTR.D

80. O00299|CLIC1_HUMAN Mass: 27248 Score: 66 Queries matched: 6 emPAI: 0.48 Chloride intracellular channel protein 1 OS=Homo sapiens GN=CLIC1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24722 479.2343 956.4541 956.4715 -0.0175 0 33 0.026 1 R.YLSNAYAR.E 24723 28418 539.7172 1077.4199 1077.5026 -0.0827 0 38 0.0077 1 K.IGNCPFSQR.L 28400 28406 36091 664.8107 1327.6069 1327.6368 -0.0299 0 37 0.01 1 K.NSNPALNDNLEK.G

81. P31146|COR1A_HUMAN Mass: 51678 Score: 66 Queries matched: 4 emPAI: 0.15 Coronin-1A OS=Homo sapiens GN=CORO1A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4321 447.7475 893.4805 893.4971 -0.0165 0 4 24 4 K.ILTTGFSR.M 30738 569.7397 1137.4649 1137.4907 -0.0257 0 3 21 3 R.DGGLICTSCR.D 12972 643.3592 1284.7038 1284.7401 -0.0363 1 34 0.051 1 R.KLQATVQELQK.R

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38982 751.8404 1501.6663 1501.7009 -0.0345 0 57 9e-005 1 R.AAPEASGTPSSDAVSR.L

82. P02751|FINC_HUMAN Mass: 266034 Score: 65 Queries matched: 17 emPAI: 0.10 Fibronectin OS=Homo sapiens GN=FN1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16681 404.2451 806.4756 806.4902 -0.0146 0 26 0.15 1 R.ITGYIIK.Y 16682 16685 404.7151 807.4157 807.4239 -0.0082 0 26 0.15 1 R.AQITGYR.L 16687 17966 414.7429 827.4712 827.4865 -0.0152 0 10 6.4 1 R.TIKPDVR.S 24273 467.7282 933.4419 933.4702 -0.0283 0 30 0.069 1 R.ISCTIANR.C 24275 24276 7432 517.7562 1033.4978 1033.6284 -0.1306 1 3 27 10 R.ARITGYIIK.Y 28424 539.7758 1077.5371 1077.5455 -0.0084 0 23 0.31 1 R.QYNVGPSVSK.Y 28423 29681 555.7691 1109.5237 1109.5353 -0.0116 0 21 0.39 1 R.STTPDITGYR.I 10730 584.2720 1166.5294 1166.5390 -0.0096 0 16 3.1 1 R.FTNIGPDTM R.V 35987 662.3528 1322.6910 1322.7055 -0.0145 0 29 0.054 1 K.LGVRPSQGGEAPR.E 3540 39378 772.3776 1542.7407 1542.7566 -0.0159 0 41 0.0032 1 R.SYTITGLQPGTDYK.I 11910 608.3535 1822.0388 1821.9472 0.0915 1 15 4.3 1 R.VTDATETTITISWRTK.T

83. O00241|SIRB1_HUMAN Mass: 43658 Score: 63 Queries matched: 51 emPAI: 0.09 Signal-regulatory protein beta-1 OS=Homo sapiens GN=SIRPB1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10871 587.5372 586.5300 586.3802 0.1497 0 2 34 1 R.VVLTR.G 26670 516.2947 1030.5749 1030.5407 0.0342 0 6 14 3 R.GTANLSEAIR.V 7359 30371 567.2654 1132.5163 1132.6452 -0.1289 1 36 0.015 1 R.VTTVSELTKR.N 30325 30326 30327 30329 30330 30331 30334 30335 12506 623.8190 1245.6235 1245.6353 -0.0118 0 5 17 1 K.SYALEISAHQK.E

84. Q12931|TRAP1_HUMAN Mass: 80345 Score: 63 Queries matched: 14 emPAI: 0.05 Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens GN=TRAP1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 26448 514.2628 1026.5111 1026.5934 -0.0823 1 12 3.6 1 K.LRDVLQQR.L 26443 26451 26452 26453 26458 26460 26472 26475 35379 435.2402 1302.6987 1302.6667 0.0320 0 4 18 5 R.EGIVTATEQEVK.E 39059 757.3717 1512.7289 1512.7784 -0.0495 0 63 2.4e-005 1 R.GVVDSEDIPLNLSR.E

85. P61916|NPC2_HUMAN Mass: 16902 Score: 62 Queries matched: 4 emPAI: 0.23 Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 26100 508.7489 1015.4833 1015.5121 -0.0288 0 56 0.00016 1 K.SGINCPIQK.D 26099 26101 45911 458.7297 2746.3345 2746.4187 -0.0841 1 3 10 1 K.SSKAVVHGILMGVPVPFPIPEPDGCK.S

86. Q8N1A0|KT222_HUMAN Mass: 34308 Score: 61 Queries matched: 6 emPAI: 0.11 Keratin-like protein KRT222 OS=Homo sapiens GN=KRT222 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24171 465.2699 928.5252 928.5090 0.0162 1 1 50 7 K.ELQEVRR.G 9700 561.7727 1121.5308 1121.5717 -0.0408 0 58 8.7e-005 1 R.LEQEIATYR.H 30001 30002 30003 38188 486.9550 1457.8431 1457.7184 0.1247 0 2 29 1 R.SCSIPSIKPPSTAN.-

87. P18206|VINC_HUMAN Mass: 124292 Score: 60 Queries matched: 60 emPAI: 0.03 Vinculin OS=Homo sapiens GN=VCL PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4197 447.2312 892.4479 892.4324 0.0155 0 0 1.6e+002 1 K.LEAMTNSK.Q 23761 457.2718 912.5290 912.5141 0.0149 0 6 13 4 R.AVANSRPAK.A 23713 4918 4927 23745 23750 23752 4932 23760 23 25980 505.2602 1008.5059 1008.4732 0.0327 1 1 38 4 K.MAKMIDER.Q 25974 25976 25987 25988 25999 26579 514.7876 1027.5607 1027.5774 -0.0167 1 1 39 8 K.GNDIIAAAKR.M 28306 537.7701 1073.5257 1073.4890 0.0367 0 1 45 9 R.AANFENHSGK.L 29771 557.7796 1113.5446 1113.5778 -0.0332 1 3 27 1 K.GDSPEARALAK.Q 34508 634.3189 1266.6233 1266.6312 -0.0079 0 3 22 7 R.VMLVNSMNTVK.E 34545 635.3358 1268.6570 1268.6725 -0.0154 0 60 4.8e-005 1 K.AVAGNISDPGLQK.S 2636 428.8764 1283.6074 1283.7058 -0.0984 1 2 33 3 K.TNRAVANSRPAK.A 35506 654.7882 1307.5618 1307.6279 -0.0661 0 5 14 6 K.MTGLVDEAIDTK.S 3543 442.1815 1323.5226 1323.6461 -0.1235 1 (3) 53 3 K.RMALLMAEMSR.L 3721 444.8712 1331.5919 1331.6616 -0.0697 1 17 1.2 1 R.ARGQGSSPVAMQK.A 13343 3706 3707 3708 3709 3710 3711 3712 37 36264 670.8322 1339.6498 1339.6410 0.0088 1 5 14 8 K.RMALLMAEMSR.L

88. Q86U44|MTA70_HUMAN Mass: 65175 Score: 57 Queries matched: 28 emPAI: 0.06 N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 26121 508.7729 1015.5312 1015.5410 -0.0098 1 41 0.0055 2 K.QLDSLRER.L 26102 7026 7027 26103 7028 7029 7030 26104 26105 2 29568 554.2458 1106.4770 1106.5464 -0.0694 0 4 20 7 K.LSAMMGAVAEK.K 33411 618.2914 1234.5683 1234.6413 -0.0730 1 (3) 24 1 K.LSAMMGAVAEKK.G 33409 2235 423.2423 1266.7051 1266.6312 0.0739 1 3 1e+002 5 K.LSAMMGAVAEKK.G

89. P01833|PIGR_HUMAN Mass: 84429 Score: 57 Queries matched: 11 emPAI: 0.14 Polymeric immunoglobulin receptor OS=Homo sapiens GN=PIGR PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13660 675.3950 674.3878 674.3347 0.0530 1 5 26 1 R.KEDAGR.Y 23461 452.2359 902.4573 902.4722 -0.0149 1 38 0.0099 1 K.RAPAFEGR.I 23459 23460 23462 23463 23464 4625 40990 584.2907 1749.8503 1749.8720 -0.0217 1 31 0.029 1 R.TVTINCPFKTENAQK.R 10731 42511 724.3125 2169.9156 2169.9597 -0.0441 1 31 0.017 1 R.LSDAGQYLCQAGDDSNSNKK.N

90. Q9BYE4|SPR2G_HUMAN Mass: 8779 Score: 56 Queries matched: 5 emPAI: 0.46 Small proline-rich protein 2G OS=Homo sapiens GN=SPRR2G PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 28465 541.2296 1080.4447 1080.4732 -0.0286 0 56 0.00011 1 K.CPEPCPPPK.C 11955 608.8139 1215.6132 1215.5012 0.1120 0 4 21 1 -.MSYQQQQCK.Q 43859 428.8827 2567.2528 2567.1794 0.0735 1 2 12 2

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K.QPCQPPPVCPTPKCPEPCPPPK.C 43930 43973

Proteins matching the same set of peptides: P22532|SPR2D_HUMAN Mass: 8584 Score: 56 Queries matched: 5 Small proline-rich protein 2D OS=Homo sapiens GN=SPRR2D PE=2 SV=2 P22531|SPR2E_HUMAN Mass: 8591 Score: 56 Queries matched: 5 Small proline-rich protein 2E OS=Homo sapiens GN=SPRR2E PE=2 SV=2 P35325|SPR2B_HUMAN Mass: 8597 Score: 56 Queries matched: 5 Small proline-rich protein 2B OS=Homo sapiens GN=SPRR2B PE=2 SV=1 P35326|SPR2A_HUMAN Mass: 8587 Score: 56 Queries matched: 5 Small proline-rich protein 2A OS=Homo sapiens GN=SPRR2A PE=2 SV=1

91. P61981|1433G_HUMAN Mass: 28456 Score: 56 Queries matched: 6 emPAI: 0.46 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23466 452.2468 902.4791 902.5073 -0.0282 0 39 0.0083 1 R.VISSIEQK.T 23467 23550 454.2559 906.4973 906.5174 -0.0202 0 34 0.023 1 R.NLLSVAYK.N 23551 23552 28455 540.7659 1079.5172 1079.5499 -0.0327 0 38 0.0083 1 R.YLAEVATGEK.R

92. P06753|TPM3_HUMAN Mass: 32856 Score: 55 Queries matched: 38 emPAI: 0.39 Tropomyosin alpha-3 chain OS=Homo sapiens GN=TPM3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24427 471.7651 941.5156 941.5658 -0.0502 1 2 34 2 K.VIENRALK.D 29568 554.2458 1106.4770 1106.5720 -0.0950 1 8 8.6 4 R.AEFAERSVAK.L 31907 591.7679 1181.5212 1181.5452 -0.0239 1 9 5.7 1 K.EDKYEEEIK.I 11236 11238 35860 658.8087 1315.6028 1315.6368 -0.0339 0 41 0.0038 1 K.AADAEAEVASLNR.R 38331 738.3746 1474.7346 1474.7701 -0.0355 1 31 0.035 2 K.MELQEIQLKEAK.H 38320 38322 38323 38324 38325 38326 38327 3832 38362 738.8185 1475.6225 1475.6739 -0.0514 1 35 0.014 1 K.LEEAEKAADESER.G

93. P04040|CATA_HUMAN Mass: 59947 Score: 54 Queries matched: 1 emPAI: 0.06 Catalase OS=Homo sapiens GN=CAT PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 38839 747.3461 1492.6777 1492.6906 -0.0129 0 54 0.00018 1 R.FNTANDDNVTQVR.A

94. Q9Y240|CLC11_HUMAN Mass: 36015 Score: 53 Queries matched: 7 emPAI: 0.10 C-type lectin domain family 11 member A OS=Homo sapiens GN=CLEC11A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 27033 523.2762 1044.5378 1044.5750 -0.0372 1 3 30 10 R.LEGCLKGLR.L 27120 9280 551.2401 1100.4656 1100.5686 -0.1030 1 4 70 2 R.QLRNAAGDTR.D 10987 589.3255 1176.6365 1176.5523 0.0842 0 0 1.9e+002 1 R.DFEAQAAAQAR.C 34901 643.3101 1284.6055 1284.6422 -0.0367 0 53 0.0002 1 R.DAVQALQEAQGR.A 34902 37232 697.2997 1392.5847 1392.6536 -0.0689 1 0 40 3 R.RLYYVCEFPF.-

95. P09467|F16P1_HUMAN Mass: 37190 Score: 52 Queries matched: 7 emPAI: 0.21 Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6749 502.2731 501.2659 501.2547 0.0112 0 1 1.7e+002 1 K.SPNGK.L 10603 579.2947 1156.5748 1156.5764 -0.0016 0 45 0.0058 1 K.IYSLNEGYAK.D 31115 31117 31119 581 411.8580 1232.5520 1232.5972 -0.0452 0 2 30 4 R.YVGSMVADVHR.T 40088 543.9202 1628.7389 1628.7642 -0.0253 1 32 0.026 1 K.STDEPSEKDALQPGR.N

96. P11215|ITAM_HUMAN Mass: 128410 Score: 51 Queries matched: 10 emPAI: 0.06 Integrin alpha-M OS=Homo sapiens GN=ITGAM PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22429 436.7493 871.4840 871.4875 -0.0036 0 18 1 1 K.TIQNQLR.E 24493 473.2653 944.5160 944.5039 0.0121 0 2 46 10 K.VSTLQNQR.S 24646 478.2445 954.4744 954.3679 0.1065 0 2 29 7 R.NDGEDSYR.T 25398 492.7377 983.4608 983.5512 -0.0904 1 4 20 5 R.THTATGIRK.V 30671 567.7697 1133.5248 1133.5829 -0.0581 0 8 8.7 8 R.ELFNITNGAR.K 10752 585.3011 1168.5877 1168.6023 -0.0146 0 37 0.025 1 R.GGQVSVCPLPR.G 36034 663.8723 1325.7299 1325.6537 0.0762 0 2 30 1 K.EFVSTVM EQLK.K 36303 671.3386 1340.6627 1340.7201 -0.0574 1 4 19 7 R.QQPQKFPEALR.G 39448 775.9318 1549.8490 1549.8576 -0.0087 0 38 0.0065 1 R.VVVGAPQEIVAANQR.G 10055 567.3191 1698.9356 1698.9086 0.0269 1 1 96 6 K.LLLKANVTSENNMPR.T

97. P60900|PSA6_HUMAN Mass: 27838 Score: 50 Queries matched: 2 emPAI: 0.14 Proteasome subunit alpha type-6 OS=Homo sapiens GN=PSMA6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 34904 643.3451 1284.6755 1284.7150 -0.0394 0 50 0.00043 1 K.AINQGGLTSVAVR.G 41046 589.9560 1766.8461 1766.9050 -0.0589 1 2 22 5 K.ATAAGVKQTESTSFLEK.K

98. P19971|TYPH_HUMAN Mass: 50323 Score: 50 Queries matched: 7 emPAI: 0.15 Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 27505 528.2478 1054.4809 1054.5407 -0.0598 0 5 15 2 R.GLGHTGGTLDK.L 28579 542.7659 1083.5171 1083.5309 -0.0137 0 27 0.12 1 R.DGPALSGPQSR.A 28578 30804 571.8507 1141.6869 1141.6819 0.0050 0 1 41 8 K.TLVGVGASLGLR.V 32587 608.2983 1214.5821 1214.6255 -0.0434 0 38 0.0082 1 R.VAAALDDGSALGR.F 32591 35828 657.7578 1313.5011 1313.6762 -0.1750 0 2 20 3 R.M LAAQGVDPGLAR.A

99. P09960|LKHA4_HUMAN Mass: 69868 Score: 49 Queries matched: 3 emPAI: 0.11 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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25415 493.2796 984.5446 984.5604 -0.0158 0 18 0.83 1 K.VVINGQEVK.Y 35828 657.7578 1313.5011 1313.5372 -0.0360 0 39 0.0037 1 R.DGETPDPEDPSR.K 36094 664.8455 1327.6765 1327.6806 -0.0041 0 30 0.049 1 R.AILPCQDTPSVK.L

100. P20742|PZP_HUMAN Mass: 165242 Score: 48 Queries matched: 7 emPAI: 0.02 Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8832 543.3107 542.3034 542.3540 -0.0506 0 2 29 3 K.GVIVR.S 22922 443.7164 885.4183 885.4345 -0.0162 0 19 0.87 1 R.YGAATFTR.T 26233 509.7949 1017.5753 1017.5859 -0.0105 0 1 52 1 K.ATVLNYLPK.C 9355 552.2964 1102.5782 1102.5982 -0.0200 0 48 0.002 1 R.SSGSLLNNAIK.G 29358 39154 761.3590 1520.7035 1520.7834 -0.0799 1 1 36 7 R.ENRSLFTDLVAEK.D 10794 587.2690 1758.7852 1758.7710 0.0142 1 7 34 1 K.HQDGSYSTFGERYGR.N

101. Q5VTE0|EF1A3_HUMAN Mass: 50495 Score: 48 Queries matched: 7 emPAI: 0.07 Putative elongation factor 1-alpha-like 3 OS=Homo sapiens GN=EEF1AL3 PE=5 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23465 452.2451 902.4757 902.4570 0.0187 1 5 20 8 R.RGNVAGDSK.N 6165 488.2665 974.5185 974.5437 -0.0251 0 20 2.2 1 R.LPLQDVYK.I 7222 513.2981 1024.5816 1024.6030 -0.0214 0 36 0.029 1 K.IGGIGTVPVGR.V 26419 26423 26424 26425

Proteins matching the same set of peptides: P68104|EF1A1_HUMAN Mass: 50451 Score: 48 Queries matched: 7 Elongation factor 1-alpha 1 OS=Homo sapiens GN=EEF1A1 PE=1 SV=1

102. P40925|MDHC_HUMAN Mass: 36631 Score: 48 Queries matched: 3 emPAI: 0.10 Malate dehydrogenase, cytoplasmic OS=Homo sapiens GN=MDH1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23794 458.7538 915.4929 915.5025 -0.0096 0 48 0.0011 1 K.LGVTANDVK.N 24554 476.2228 950.4311 950.4743 -0.0431 1 1 46 9 R.EKMDLTAK.E 10252 569.6657 1705.9753 1705.8457 0.1296 1 2 22 8 K.SAPSIPKENFSCLTR.L

103. Q8TER0|SNED1_HUMAN Mass: 158206 Score: 47 Queries matched: 45 emPAI: 0.02 Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens GN=SNED1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10499 576.2856 575.2784 575.2663 0.0120 0 5 28 3 R.NSNNK.N 10498 10500 13091 650.3311 649.3238 649.2602 0.0636 0 0 1.6e+002 10 R.NGGSCR.N 13528 670.2588 669.2515 669.3810 -0.1295 0 1 57 2 R.DLLPGR.R 16708 405.2143 808.4140 808.4443 -0.0303 0 35 0.016 2 K.LASYTVR.D 186 16697 16698 16699 16701 16702 16703 16704 167 29202 550.2325 1098.4504 1098.5029 -0.0525 1 4 18 2 R.GFHGKHCEK.A 31787 589.3374 1176.6603 1176.6251 0.0352 1 4 20 1 R.FGGSPSKAATVR.S 31617

104. Q14974|IMB1_HUMAN Mass: 98420 Score: 47 Queries matched: 4 emPAI: 0.04 Importin subunit beta-1 OS=Homo sapiens GN=KPNB1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9402 553.2611 1104.5076 1104.6100 -0.1024 0 4 64 3 -.MELITILEK.T 9394 33092 613.3238 1224.6331 1224.6575 -0.0244 0 47 0.00094 1 R.VLANPGNSQVAR.V 5115 460.8680 1379.5821 1379.6503 -0.0682 1 9 6.2 2 K.NSAKDCYPAVQK.T

105. P0C869|PA24B_HUMAN Mass: 89093 Score: 47 Queries matched: 7 emPAI: 0.04 Cytosolic phospholipase A2 beta OS=Homo sapiens GN=PLA2G4B PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10498 576.2800 575.2728 575.3279 -0.0551 0 13 3.8 2 K.TQVTK.N 25075 486.7411 971.4677 971.5148 -0.0471 1 (39) 0.0085 1 R.QELAERAR.L 25076 25078 25079 25080 45724 449.7222 2692.2897 2692.4734 -0.1838 1 1 17 1 K.APLSALPSGQVVRLVFPTSQEPLMR.V

106. P14649|MYL6B_HUMAN Mass: 22864 Score: 46 Queries matched: 24 emPAI: 0.17 Myosin light chain 6B OS=Homo sapiens GN=MYL6B PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2376 426.2735 1275.7986 1275.6241 0.1744 1 5 36 1 K.EGNGKVMGAELR.H 2316 2320 2321 2327 2332 2338 2346 2351 2352 23 36593 677.8440 1353.6734 1353.7252 -0.0518 0 46 0.0011 1 R.ALGQNPTNAEVLK.V

107. P05155|IC1_HUMAN Mass: 55347 Score: 46 Queries matched: 6 emPAI: 0.14 Plasma protease C1 inhibitor OS=Homo sapiens GN=SERPING1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17241 409.7013 817.3880 817.4909 -0.1029 0 11 5.5 6 K.VATTVISK.M 23587 455.7243 909.4341 909.4556 -0.0215 0 28 0.086 1 R.TLYSSSPR.V 23588 23589 29827 558.7901 1115.5657 1115.5822 -0.0166 0 41 0.0039 1 R.LLDSLPSDTR.L 11336 593.3338 1184.6531 1184.6917 -0.0386 0 2 1e+002 2 K.FQPTLLTLPR.I

108. P01034|CYTC_HUMAN Mass: 16017 Score: 46 Queries matched: 3 emPAI: 0.24 Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 33095 613.7901 1225.5656 1225.5979 -0.0323 0 40 0.0051 1 R.ALDFAVGEYNK.A 33094 41293 606.2769 1815.8088 1815.8785 -0.0697 1 11 2.7 1 R.LVGGPM DASVEEEGVRR.A

109. P31949|S10AB_HUMAN Mass: 11847 Score: 46 Queries matched: 5 emPAI: 0.33 Protein S100-A11 OS=Homo sapiens GN=S100A11 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7106 510.2471 1018.4797 1018.4931 -0.0134 0 24 0.59 1 K.ISSPTETER.C 7105 26257 27715 530.7402 1059.4658 1059.4873 -0.0215 0 46 0.0018 1 K.DGYNYTLSK.T 32085 597.3353 1192.6561 1192.5580 0.0981 1 5 15 1 K.DPGVLDRM MK.K

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110. P35754|GLRX1_HUMAN Mass: 12053 Score: 45 Queries matched: 1 emPAI: 0.33 Glutaredoxin-1 OS=Homo sapiens GN=GLRX PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22203 435.7664 869.5182 869.5334 -0.0152 1 45 0.0015 1 R.LKQIGALQ.-

111. O00175|CCL24_HUMAN Mass: 13467 Score: 43 Queries matched: 6 emPAI: 0.67 C-C motif chemokine 24 OS=Homo sapiens GN=CCL24 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19825 423.2062 844.3978 844.4191 -0.0213 0 40 0.0075 1 K.QEWVQR.Y 26820 519.7745 1037.5345 1037.5506 -0.0161 0 34 0.023 1 R.VVSYQLSSR.S 26819 26821 7507 31308 582.7634 1163.5122 1163.5394 -0.0272 1 8 7.8 2 K.KGQQFCGDPK.Q

112. P31947|1433S_HUMAN Mass: 27871 Score: 43 Queries matched: 10 emPAI: 0.29 14-3-3 protein sigma OS=Homo sapiens GN=SFN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6871 503.3703 502.3631 502.2751 0.0880 0 11 13 10 K.GAVEK.G 6823 20595 429.7253 857.4361 857.5334 -0.0973 1 3 40 3 R.ASLIQKAK.L 20593 23466 452.2468 902.4791 902.5073 -0.0282 0 39 0.0083 1 R.VLSSIEQK.S 23467 23550 454.2559 906.4973 906.5174 -0.0202 0 34 0.023 1 R.NLLSVAYK.N 23551 23552 9674 561.2892 1120.5639 1120.4569 0.1070 0 1 1.7e+002 1 R.YEDMAAFMK.G

113. Q15582|BGH3_HUMAN Mass: 75261 Score: 43 Queries matched: 4 emPAI: 0.05 Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens GN=TGFBI PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3703 444.7217 887.4288 887.5076 -0.0788 1 8 10 6 R.LKSLQGDK.L 24104 465.2455 928.4764 928.4978 -0.0214 0 43 0.0034 1 K.IPSETLNR.I 25348 492.2682 982.5218 982.5447 -0.0230 0 8 8 1 R.ILGDPEALR.D 25330

114. P00918|CAH2_HUMAN Mass: 29285 Score: 42 Queries matched: 5 emPAI: 0.28 Carbonic anhydrase 2 OS=Homo sapiens GN=CA2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24280 468.2245 934.4344 934.4509 -0.0165 0 21 0.46 1 K.GGPLDGTYR.L 24279 25434 494.2842 986.5538 986.5648 -0.0110 0 35 0.019 1 K.VVDVLDSIK.T 31419 585.2555 1168.4964 1168.5149 -0.0185 0 32 0.028 1 K.SADFTNFDPR.G 31420

115. P31946|1433B_HUMAN Mass: 28179 Score: 42 Queries matched: 10 emPAI: 0.66 14-3-3 protein beta/alpha OS=Homo sapiens GN=YWHAB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23466 452.2468 902.4791 902.5073 -0.0282 0 39 0.0083 1 R.VISSIEQK.T 23467 23550 454.2559 906.4973 906.5174 -0.0202 0 34 0.023 1 R.NLLSVAYK.N 23551 23552 11235 591.7661 1181.5177 1181.5564 -0.0387 0 17 0.89 1 R.YLSEVASGDNK.Q 33786 626.7937 1251.5728 1251.6394 -0.0666 1 13 2.1 3 K.KEMQPTHPIR.L 33781 33783 16466 799.8577 1597.7008 1597.7332 -0.0324 0 21 0.3 1 K.AVTEQGHELSNEER.N

116. P78417|GSTO1_HUMAN Mass: 27833 Score: 42 Queries matched: 4 emPAI: 0.14 Glutathione S-transferase omega-1 OS=Homo sapiens GN=GSTO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5189 463.7030 925.3914 925.4116 -0.0202 0 13 2.6 1 R.FCPFAER.T 28871 545.3079 1088.6012 1088.5390 0.0622 0 2 36 10 K.LLPDDPYEK.A 11765 606.7773 1211.5400 1211.5605 -0.0205 0 1 38 3 K.LNECVDHTPK.L 35922 660.8348 1319.6551 1319.6834 -0.0282 0 42 0.0031 1 K.GSAPPGPVPEGSIR.I

117. Q06830|PRDX1_HUMAN Mass: 22324 Score: 41 Queries matched: 5 emPAI: 0.61 Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25303 490.7564 979.4983 979.5239 -0.0256 0 25 0.15 1 K.IGHPAPNFK.A 29606 554.2854 1106.5563 1106.5972 -0.0409 0 27 0.1 1 R.TIAQDYGVLK.A 29607 32232 598.7965 1195.5784 1195.6237 -0.0453 0 30 0.052 1 R.LVQAFQFTDK.H 11510

118. P55058|PLTP_HUMAN Mass: 54933 Score: 41 Queries matched: 1 emPAI: 0.07 Phospholipid transfer protein OS=Homo sapiens GN=PLTP PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 36087 664.3117 1326.6089 1326.6415 -0.0326 0 41 0.0036 1 R.AVEPQLQEEER.M

119. Q99536|VAT1_HUMAN Mass: 42122 Score: 41 Queries matched: 12 emPAI: 0.09 Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens GN=VAT1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 38382 740.3793 1478.7440 1478.7803 -0.0363 0 29 0.055 1 K.VVTYGMANLLTGPK.R 38383 14267 38384 38385 45218 435.0963 2604.5340 2604.3853 0.1488 0 2 4.7 1 R.LLALYNQGHIKPHIDSVWPFEK.V 45192 45196 45202 45203 45204 45212

120. P37837|TALDO_HUMAN Mass: 37688 Score: 40 Queries matched: 4 emPAI: 0.10 Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13303 661.3852 660.3779 660.3442 0.0337 0 3 39 1 R.NTGEIK.A 28307 537.7702 1073.5259 1073.5353 -0.0094 0 40 0.0057 1 K.LGGSQEDQIK.N 28287 36677 681.3284 1360.6423 1360.6874 -0.0451 1 4 23 6 K.KSYEPLEDPGVK.S

121. Q9Y281|COF2_HUMAN Mass: 18839 Score: 40 Queries matched: 1 emPAI: 0.20 Cofilin-2 OS=Homo sapiens GN=CFL2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 36167 669.2953 1336.5760 1336.6187 -0.0427 0 40 0.0045 1 R.YALYDATYETK.E

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Proteins matching the same set of peptides: P23528|COF1_HUMAN Mass: 18719 Score: 40 Queries matched: 1 Cofilin-1 OS=Homo sapiens GN=CFL1 PE=1 SV=3

122. P28065|PSB9_HUMAN Mass: 23364 Score: 40 Queries matched: 4 emPAI: 0.16 Proteasome subunit beta type-9 OS=Homo sapiens GN=PSMB9 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25698 501.2555 1000.4964 1000.5302 -0.0338 0 40 0.0067 1 R.VSAGEAVVNR.V 48162 1093.9105 3278.7098 3278.5449 0.1649 1 2 7.4 3 R.EDLSAHLMVAGWDQREGGQVYGTLGGMLTR.Q 48161 48163

123. P08758|ANXA5_HUMAN Mass: 35971 Score: 39 Queries matched: 2 emPAI: 0.10 Annexin A5 OS=Homo sapiens GN=ANXA5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25883 501.2911 1000.5676 1000.5917 -0.0240 0 39 0.0075 1 K.VLTEIIASR.T 26043 507.7501 1013.4857 1013.5069 -0.0213 0 12 4 1 R.LYDAYELK.H

124. P37802|TAGL2_HUMAN Mass: 22548 Score: 38 Queries matched: 3 emPAI: 0.17 Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17282 410.7086 819.4026 819.4239 -0.0213 0 16 1.7 1 R.GPAYGLSR.E 32699 609.7895 1217.5645 1217.6187 -0.0542 0 17 1 1 K.NVIGLQMGTNR.G 34682 640.2731 1278.5317 1278.5840 -0.0523 0 38 0.0065 1 R.NFSDNQLQEGK.N

125. Q15648|MED1_HUMAN Mass: 169342 Score: 38 Queries matched: 72 emPAI: 0.02 Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens GN=MED1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10728 584.2536 583.2463 583.3329 -0.0866 0 7 22 1 K.DKPPK.R 13090 650.2386 649.2314 649.3105 -0.0791 0 5 33 2 R.QVM EK.R 3658 443.7027 885.3909 885.4556 -0.0647 0 5 19 4 K.ATNAGPLDK.I 25081 486.7656 971.5167 971.4858 0.0309 0 2 46 2 R.SGGHLMNLK.Y 28985 545.7641 1089.5136 1089.5488 -0.0352 0 12 4 6 K.VTSLPAMTDR.L 28954 28955 28959 28960 28961 28966 28969 28970 29451 553.7496 1105.4846 1105.5438 -0.0591 0 (9) 6.5 4 K.VTSLPAMTDR.L 29453 29455 29457 29461 29462 29465 29472 29479 29576 554.2591 1106.5035 1106.4727 0.0308 0 32 0.036 3 K.AQGETEESEK.L 29567 29569 29570 29571 29573 29574 29575 29577 30136 563.7760 1125.5375 1125.4981 0.0394 0 6 11 1 R.CMSIPVTMR.A 30134 30143 12412 618.3495 1234.6845 1234.5677 0.1168 1 3 97 1 M.KAQGETEESEK.L 33837 627.7985 1253.5824 1253.5744 0.0080 1 0 43 10 R.MEICSGSNKTK.K 8540 537.2385 1608.6936 1608.8545 -0.1609 0 3 90 1 K.LASPM KPVPGTPPSSK.A

126. P18084|ITB5_HUMAN Mass: 91303 Score: 38 Queries matched: 3 emPAI: 0.04 Integrin beta-5 OS=Homo sapiens GN=ITGB5 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20599 430.7655 859.5164 859.4035 0.1128 0 1 56 8 K.DDLDNIR.S 6000 485.2530 968.4915 968.4968 -0.0052 0 38 0.021 1 R.LGFGSFVDK.D 33053 408.2025 1221.5856 1221.5990 -0.0133 1 4 19 1 R.VDSFNEEVRK.Q

127. P16150|LEUK_HUMAN Mass: 40297 Score: 38 Queries matched: 1 emPAI: 0.09 Leukosialin OS=Homo sapiens GN=SPN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17116 408.7440 815.4734 815.4865 -0.0131 0 38 0.012 1 R.TGALVLSR.G

128. Q08EQ4|TMSL1_HUMAN Mass: 5067 Score: 38 Queries matched: 3 emPAI: 0.85 Thymosin beta-4-like protein 1 OS=Homo sapiens GN=TMSL1 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 36379 674.8025 1347.5905 1347.6154 -0.0248 1 38 0.009 1 K.ETIEQEKQAGES.- 38063 722.3036 1442.5926 1442.5727 0.0198 0 (2) 24 2 -.MSDKPDMAEMEK.F 38071 722.3101 1442.6055 1442.5727 0.0328 0 2 22 9 -.MSDKPDMAEMEK.F

129. P52790|HXK3_HUMAN Mass: 100616 Score: 37 Queries matched: 8 emPAI: 0.07 Hexokinase-3 OS=Homo sapiens GN=HK3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10132 567.3525 566.3453 566.3289 0.0164 0 5 13 1 R.LAAHR.R 26554 514.7552 1027.4959 1027.5047 -0.0088 0 20 0.6 1 R.NVAGVPGDSGR.M 27100 523.2829 1044.5512 1044.5676 -0.0164 1 2 39 10 K.GLRGEASSLR.M 26912 26952 7788 27776 531.2849 1060.5552 1060.5699 -0.0147 0 35 0.019 1 R.GVAMVTAVAAR.L 28670 544.7866 1087.5586 1087.5808 -0.0222 0 25 0.21 1 K.GAALVTAVACR.L

130. O76054|S14L2_HUMAN Mass: 46629 Score: 37 Queries matched: 8 emPAI: 0.08 SEC14-like protein 2 OS=Homo sapiens GN=SEC14L2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16282 743.4146 742.4073 742.3974 0.0099 0 37 0.012 1 R.VGDLSPR.Q 16275 16281 16283 16284 16285 16286 16287

131. P20702|ITAX_HUMAN Mass: 128946 Score: 37 Queries matched: 5 emPAI: 0.03 Integrin alpha-X OS=Homo sapiens GN=ITGAX PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9144 547.7530 1093.4913 1093.5516 -0.0603 1 9 5.4 5 R.ATFQETKNR.S 29124 10752 585.3011 1168.5877 1168.6023 -0.0146 0 37 0.025 1 R.GGQVSVCPLPR.G 12496 623.3302 1244.6459 1244.5561 0.0899 0 3 64 1 K.YLNFSESEEK.E 13788 679.3251 1356.6355 1356.7071 -0.0716 0 0 1.3e+002 8 K.DVIPMADAAGIIR.Y

132. Q9C075|K1C23_HUMAN Mass: 48272 Score: 37 Queries matched: 6 emPAI: 0.08 Keratin, type I cytoskeletal 23 OS=Homo sapiens GN=KRT23 PE=1 SV=2

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 778 412.2223 822.4300 822.4487 -0.0187 0 25 0.45 1 R.LASYLEK.V 17471 27847 531.7362 1061.4578 1061.4924 -0.0345 0 37 0.012 1 K.ATMQNLNDR.L 27849 628 411.8621 1232.5646 1232.5938 -0.0292 1 1 44 1 K.HRDLDTWYK.E 682

133. O00626|CCL22_HUMAN Mass: 10802 Score: 37 Queries matched: 1 emPAI: 0.37 C-C motif chemokine 22 OS=Homo sapiens GN=CCL22 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 29297 552.2552 1102.4958 1102.5077 -0.0119 1 37 0.013 1 R.DKEICADPR.V

134. P80748|LV302_HUMAN Mass: 12042 Score: 36 Queries matched: 3 emPAI: 0.33 Ig lambda chain V-III region LOI OS=Homo sapiens PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22908 443.2694 884.5243 884.5331 -0.0088 0 36 0.013 1 K.LTVLSQPK.- 22895 22906

135. Q7Z6K2|TPISL_HUMAN Mass: 25016 Score: 36 Queries matched: 4 emPAI: 0.15 Putative triosephosphate isomerase-like protein LOC286016 OS=Homo sapiens PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20037 425.7256 849.4367 849.4596 -0.0229 0 36 0.015 1 K.VVFEQTK.V 31263 582.2991 1162.5837 1162.5805 0.0032 0 8 8.1 1 K.IAVAPQNCYK.V 31266 31274

136. P02788|TRFL_HUMAN Mass: 80014 Score: 36 Queries matched: 8 emPAI: 0.05 Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24286 468.2703 934.5261 934.5349 -0.0088 0 36 0.016 1 R.VPSHAVVAR.S 24466 473.2297 944.4449 944.4134 0.0314 0 10 6.7 3 K.SCHTAVDR.T 24709 478.7665 955.5185 955.5563 -0.0378 1 6 13 10 K.RKPVTEAR.S 5730 5732 7131 510.7479 1019.4813 1019.5036 -0.0223 0 7 12 1 R.DGAGDVAFIR.E 11503 598.2970 1194.5794 1194.6033 -0.0240 0 1 99 1 K.FQLFGSPSGQK.D 41263 603.2685 1806.7837 1806.7876 -0.0039 0 5 12 1 R.SNLCALCIGDEQGENK.C

137. Q9ULI0|ATD2B_HUMAN Mass: 166379 Score: 35 Queries matched: 9 emPAI: 0.02 ATPase family AAA domain-containing protein 2B OS=Homo sapiens GN=ATAD2B PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12385 618.1852 617.1780 617.3497 -0.1717 1 2 67 1 R.DVTKR.L 23213 449.7601 897.5057 897.4895 0.0162 1 5 15 9 K.VAFFMRK.G 23238 23246 23643 457.2297 912.4449 912.5029 -0.0580 1 3 27 7 K.DPGDKIIR.H 24496 473.2697 944.5248 944.5039 0.0209 1 17 1.4 8 R.SGEVERLR.M 24488 27909 532.2513 1062.4880 1062.5305 -0.0425 1 35 0.018 1 R.QLSESEKSR.M 11622 604.2881 1206.5617 1206.5750 -0.0133 1 5 59 2 R.NRCLPMNFR.A

138. P07951|TPM2_HUMAN Mass: 32945 Score: 35 Queries matched: 9 emPAI: 0.11 Tropomyosin beta chain OS=Homo sapiens GN=TPM2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23542 453.7255 905.4365 905.3978 0.0387 0 13 3 8 K.GTEDEVEK.Y 25259 488.7439 975.4732 975.5171 -0.0439 1 1 48 9 K.VIENRAM K.D 29568 554.2458 1106.4770 1106.5720 -0.0950 1 8 8.6 4 R.AEFAERSVAK.L 31907 591.7679 1181.5212 1181.5452 -0.0239 1 9 5.7 1 K.EDKYEEEIK.L 11236 11238 33280 617.7612 1233.5078 1233.5837 -0.0759 1 3 23 1 R.SEERAEVAESK.C 33281 38362 738.8185 1475.6225 1475.6739 -0.0514 1 35 0.014 1 K.LEEAEKAADESER.G

139. Q6P3X3|TTC27_HUMAN Mass: 97883 Score: 34 Queries matched: 20 emPAI: 0.04 Tetratricopeptide repeat protein 27 OS=Homo sapiens GN=TTC27 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25265 489.2553 976.4960 976.4648 0.0312 0 34 0.023 2 R.AVIDGMTDR.S 25263 25264 6176 6177 6178 6180 32578 608.2481 1214.4816 1214.6118 -0.1302 1 1 35 3 K.AFQCLSKAYK.C 35523 436.8804 1307.6193 1307.6946 -0.0752 1 6 11 1 R.AGQHGKAEEILR.Q 35508 35516 35517 35518 35519 35525 35530 3553

140. P15259|PGAM2_HUMAN Mass: 28919 Score: 34 Queries matched: 5 emPAI: 0.13 Phosphoglycerate mutase 2 OS=Homo sapiens GN=PGAM2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8228 530.2659 1058.5172 1058.5509 -0.0337 0 2 1.2e+002 1 R.HYGGLTGLNK.A 27712 29308 552.2707 1102.5269 1102.5804 -0.0535 1 9 8.1 3 R.KAMEAVAAQGK.A 29288 30964 575.8252 1149.6359 1149.6618 -0.0259 0 34 0.019 1 R.VLIAAHGNSLR.G

Proteins matching the same set of peptides: P18669|PGAM1_HUMAN Mass: 28900 Score: 34 Queries matched: 5 Phosphoglycerate mutase 1 OS=Homo sapiens GN=PGAM1 PE=1 SV=2

141. P07339|CATD_HUMAN Mass: 45037 Score: 34 Queries matched: 11 emPAI: 0.27 Cathepsin D OS=Homo sapiens GN=CTSD PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17283 410.7090 819.4035 819.4239 -0.0204 0 26 0.16 1 R.VGFAEAAR.L 17284 22615 440.2253 878.4360 878.4498 -0.0138 0 29 0.075 1 R.QVFGEATK.Q 24267 467.2563 932.4980 932.5080 -0.0099 1 14 2.5 1 R.VGFAEAARL.- 5343 26881 521.8199 1041.6253 1041.6434 -0.0181 0 18 0.98 1 K.VSTLPAITLK.L 7860 523.2871 1044.5596 1044.5968 -0.0372 0 9 19 1 K.QPGITFIAAK.F 7829 33853 628.2935 1254.5724 1254.6067 -0.0342 0 22 0.33 1 K.FDGILGM AYPR.I 17065 815.7704 2444.2893 2444.2522 0.0371 1 0 25 1 R.KAYWQVHLDQVEVASGLTLCK.E 17025

142. Q6PKX4|DOK6_HUMAN Mass: 38692 Score: 34 Queries matched: 17 emPAI: 0.10 Docking protein 6 OS=Homo sapiens GN=DOK6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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13582 672.3914 671.3841 671.3966 -0.0125 0 34 0.029 1 K.SISLPR.S 13576 13577 13578 13579 13581 13584 21176 435.2450 868.4753 868.5243 -0.0489 1 5 13 1 K.NITRLPR.E 21296 21337 21412 21420 21460 21536 13788 679.3251 1356.6355 1356.7700 -0.1344 1 1 97 4 K.LVMWPLSSLRR.Y 37929 719.3406 1436.6666 1436.8099 -0.1433 1 2 25 6 K.VTELHNIKNITR.L 45546 443.7210 2656.2823 2656.1608 0.1215 1 2 11 2 R.M CDTGEGLFTFQTREGEMIYQK.V

143. O43439|MTG8R_HUMAN Mass: 67889 Score: 34 Queries matched: 21 emPAI: 0.05 Protein CBFA2T2 OS=Homo sapiens GN=CBFA2T2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13911 685.3094 684.3021 684.3919 -0.0897 1 2 71 1 K.VGPEKR.V 26785 517.2663 1032.5180 1032.5274 -0.0094 0 34 0.026 2 K.IQAMSEVQK.A 26722 26735 26736 26748 26770 26771 26773 26774 2 34039 631.7877 1261.5609 1261.6779 -0.1169 1 4 20 5 K.AFEVIATERAR.M 2354 426.2425 1275.7056 1275.6857 0.0199 1 4 45 4 K.VKIQAMSEVQK.A

144. P31629|ZEP2_HUMAN Mass: 271108 Score: 33 Queries matched: 28 emPAI: 0.01 Transcription factor HIVEP2 OS=Homo sapiens GN=HIVEP2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8083 527.2144 526.2072 526.2863 -0.0792 0 13 5.7 1 R.APSPR.R 8077 8078 8079 8080 8100 8101 10740 584.3907 583.3834 583.3693 0.0141 0 5 9.5 1 K.NLLPK.F 10728 16285 743.4183 742.4110 742.4086 0.0024 1 32 0.042 1 R.RDLSPR.R 16275 16281 16282 16283 16284 16286 16287 21507 435.2582 868.5018 868.4403 0.0615 0 4 16 2 R.STSPQPPR.F 21166 24104 465.2455 928.4764 928.5705 -0.0941 1 8 10 6 K.LALRLSEK.K 24411 470.7573 939.4999 939.4960 0.0039 1 6 12 7 R.RYMTTIR.A 24407 24447 472.2746 942.5347 942.5433 -0.0086 0 2 32 1 K.RPVGM LVR.M 32717 610.7692 1219.5238 1219.5615 -0.0377 1 5 15 4 R.EMSQRDVSPR.R 1874 420.2197 1257.6372 1257.7081 -0.0709 1 7 32 3 R.YLIPKGDLSPR.R 3577 442.2717 1323.7932 1323.6717 0.1215 1 1 75 4 R.DLSPM RHLSPR.K 39484 783.8396 1565.6646 1565.8525 -0.1879 1 7 7.1 2 R.QPQIIPSSIRNEGK.L 40384 413.7411 1650.9353 1650.8577 0.0776 0 2 19 1 R.IATEEAALLGPDQPAR.V

145. Q9NUQ3|TXLNG_HUMAN Mass: 61061 Score: 33 Queries matched: 43 emPAI: 0.06 Gamma-taxilin OS=Homo sapiens GN=TXLNG PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25953 503.2272 1004.4399 1004.5654 -0.1256 0 21 0.45 2 K.LIEQYALR.E 6832 25946 25947 25948 25949 25950 25951 25952 259 30403 567.2799 1132.5453 1132.6604 -0.1151 1 32 0.037 2 K.KLIEQYALR.E 30332 30347 30348 30352 30363 30375 30377 30380 3 35928 661.2823 1320.5501 1320.6786 -0.1284 1 10 3.7 1 K.EKVHLQSEHSK.A

146. Q03989|ARI5A_HUMAN Mass: 64718 Score: 33 Queries matched: 24 emPAI: 0.06 AT-rich interactive domain-containing protein 5A OS=Homo sapiens GN=ARID5A PE=2 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2308 425.7521 849.4896 849.4960 -0.0064 1 7 14 3 K.IYKAVEK.L 26997 523.2738 1044.5330 1044.4836 0.0494 0 1 43 1 R.GDDGATERPK.K 26950 29716 556.2798 1110.5450 1110.5856 -0.0405 0 6 11 4 K.GTHGIMSPLAK.K 29719 30197 564.2897 1126.5648 1126.5805 -0.0157 0 (1) 37 1 K.GTHGIMSPLAK.K 9780 9781 33289 617.8259 1233.6373 1233.6830 -0.0456 1 33 0.027 2 K.LGAYELVTGRR.L 33288 33290 33291 33292 33293 33294 33295 3329 39165 762.4213 1522.8280 1522.8103 0.0177 0 4 14 1 R.LTPQEGLQAPGGSLR.E

147. Q8TF21|ANR24_HUMAN Mass: 125080 Score: 33 Queries matched: 8 emPAI: 0.03 Ankyrin repeat domain-containing protein 24 OS=Homo sapiens GN=ANKRD24 PE=2 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19007 421.2636 840.5126 840.5545 -0.0419 1 4 21 7 R.VAALIARK.G 25091 487.2443 972.4740 972.5240 -0.0500 1 33 0.031 1 R.AQEALDKAK.E 25084 25086 25087 25088 25093 25910 502.2649 1002.5153 1002.5069 0.0084 0 0 52 10 K.SAFHLAAMR.G

148. Q13733|AT1A4_HUMAN Mass: 115119 Score: 33 Queries matched: 142 emPAI: 0.03 Sodium/potassium-transporting ATPase subunit alpha-4 OS=Homo sapiens GN=ATP1A4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 26736 517.2533 1032.4921 1032.5703 -0.0782 0 33 0.03 1 K.LTLEELSTK.Y 26700 26701 26702 26703 26704 26705 26706 26707 2 31314 582.7736 1163.5325 1163.5683 -0.0358 0 3 24 7 K.GTVAPHDQSPR.R 31311 3909 446.8730 1337.5973 1337.6510 -0.0537 1 9 5.8 1 R.NSLFQQGMRNK.V 3832 3837 3838 3841 3845 3850 3851 3854 3856 38

149. Q5VVW2|GARL3_HUMAN Mass: 113808 Score: 33 Queries matched: 3 emPAI: 0.03 GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Homo sapiens GN=GARNL3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8397 534.2713 533.2640 533.2809 -0.0169 0 3 80 1 K.TGTQK.I 22203 435.7664 869.5182 869.5698 -0.0516 1 33 0.026 4 R.IGQALKLK.S 29568 554.2458 1106.4770 1106.5641 -0.0871 0 13 2.6 1 K.SILSAMNLDK.F

150. Q16769|QPCT_HUMAN Mass: 40965 Score: 33 Queries matched: 6 emPAI: 0.09 Glutaminyl-peptide cyclotransferase OS=Homo sapiens GN=QPCT PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 30068 563.2574 1124.5003 1124.5251 -0.0247 0 34 0.019 1 R.YPGSPGSYAAR.Q 30071 30073 30076 30079 30086

151. P80075|CCL8_HUMAN Mass: 11524 Score: 32 Queries matched: 1 emPAI: 0.34 C-C motif chemokine 8 OS=Homo sapiens GN=CCL8 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25098 487.2548 972.4950 972.5062 -0.0113 0 32 0.036 1 R.ITNIQCPK.E

152. Q6NSJ5|LRC8E_HUMAN Mass: 91417 Score: 32 Queries matched: 3 emPAI: 0.04 Leucine-rich repeat-containing protein 8E OS=Homo sapiens GN=LRRC8E PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1426 417.7261 833.4377 833.5011 -0.0634 1 13 3.9 2 K.ALFEKVK.K 5350 467.2605 932.5065 932.4749 0.0315 1 0 1.1e+002 1 R.VKCEELR.E

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25238 488.2956 974.5766 974.5583 0.0183 1 32 0.039 1 R.QTVLKVCK.F

153. Q9NY47|CA2D2_HUMAN Mass: 130992 Score: 32 Queries matched: 21 emPAI: 0.03 Voltage-dependent calcium channel subunit alpha-2/delta-2 OS=Homo sapiens GN=CACNA2D2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7225 513.3134 512.3061 512.3071 -0.0010 0 1 76 7 M.AVPAR.T 26126 509.2639 1016.5133 1016.5767 -0.0634 0 10 6.8 8 R.IFGGVQQLR.E 26288 511.2173 1020.4201 1020.5604 -0.1403 1 32 0.036 1 K.KIDLYDVR.R 26289 26291 26292 26293 26294 26296 26297 27725 530.7742 1059.5339 1059.5924 -0.0585 1 4 26 9 R.TLVKSLDER.Y 27718 28301 537.7664 1073.5183 1073.5393 -0.0210 0 17 1.3 2 K.LDLEAWAEK.F 28304 28305 28307 29477 553.7744 1105.5342 1105.5404 -0.0062 0 3 31 6 R.LADAAENFQK.A 11425 596.2660 1190.5174 1190.5601 -0.0427 0 4 48 1 R.LEQEVDGVMR.I 32030 32035 32055

154. P26447|S10A4_HUMAN Mass: 11949 Score: 32 Queries matched: 5 emPAI: 0.33 Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3779 445.7423 889.4700 889.4909 -0.0209 0 14 2.5 1 R.ELPSFLGK.R 3780 28005 533.2544 1064.4942 1064.5251 -0.0309 1 32 0.034 1 K.RTDEAAFQK.L 28007 28016

155. P28066|PSA5_HUMAN Mass: 26565 Score: 32 Queries matched: 2 emPAI: 0.14 Proteasome subunit alpha type-5 OS=Homo sapiens GN=PSMA5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 27909 532.2513 1062.4880 1062.5094 -0.0214 0 32 0.036 2 R.GVNTFSPEGR.L 8424 535.2317 1602.6734 1602.8287 -0.1553 1 0 1.7e+002 1 K.RITSPLMEPSSIEK.I

156. Q63ZY3|KANK2_HUMAN Mass: 91916 Score: 32 Queries matched: 15 emPAI: 0.04 KN motif and ankyrin repeat domain-containing protein 2 OS=Homo sapiens GN=KANK2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13582 672.3914 671.3841 671.3966 -0.0125 0 32 0.047 2 R.LSSLPR.G 13576 13577 13578 13579 13581 13584 29239 551.2872 1100.5598 1100.6189 -0.0591 1 8 9.2 1 K.LSVLQEEKR.Q 29236 29240 29241 29243 29244 29245 29250

157. O76009|KT33A_HUMAN Mass: 47166 Score: 32 Queries matched: 8 emPAI: 0.16 Keratin, type I cuticular Ha3-I OS=Homo sapiens GN=KRT33A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17468 412.1991 822.3837 822.3872 -0.0035 0 11 4.4 1 K.LASDDFR.T 778 412.2223 822.4300 822.4487 -0.0187 0 25 0.45 1 R.LASYLEK.V 17471 25464 494.7666 987.5187 987.5237 -0.0049 0 17 1.2 1 K.TIEELQQK.I 25462 25465 25676 500.2868 998.5591 998.5760 -0.0169 0 24 0.19 1 R.LVVQIDNAK.L 32292 599.2715 1196.5284 1196.5495 -0.0212 0 28 0.08 1 R.LECEINTYR.S

158. Q86XW9|TXND6_HUMAN Mass: 37232 Score: 31 Queries matched: 3 emPAI: 0.10 Thioredoxin domain-containing protein 6 OS=Homo sapiens GN=TXNDC6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13552 671.3341 670.3268 670.3398 -0.0130 0 1 1e+002 9 R.DPNVAR.R 22639 440.6966 879.3786 879.3974 -0.0188 0 31 0.045 1 K.AGEEAFEK.L 31157 580.2302 1158.4458 1158.6132 -0.1674 0 6 13 3 K.TILDQLEAEK.K

159. Q8NES3|LFNG_HUMAN Mass: 42260 Score: 31 Queries matched: 6 emPAI: 0.09 Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe OS=Homo sapiens GN=LFNG PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17628 412.2515 822.4885 822.4824 0.0061 1 8 7.6 1 K.RNAVHVK.G 842 17663 4501 450.2401 898.4657 898.3855 0.0803 0 10 21 1 K.MAVEYDR.F 23251 10669 581.2684 1160.5223 1160.5462 -0.0239 0 31 0.11 1 K.GPFSVEADPSR.F

160. O75347|TBCA_HUMAN Mass: 12904 Score: 31 Queries matched: 1 emPAI: 0.31 Tubulin-specific chaperone A OS=Homo sapiens GN=TBCA PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 28243 537.2661 1072.5177 1072.5513 -0.0336 0 31 0.052 1 K.QAEILQESR.M

161. P05109|S10A8_HUMAN Mass: 10885 Score: 31 Queries matched: 7 emPAI: 0.37 Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14127 713.3470 712.3397 712.3690 -0.0293 0 2 81 1 K.MGVAAHK.K 22614 440.2163 878.4181 878.4419 -0.0238 0 22 0.38 1 -.MLTELEK.A 37677 711.3355 1420.6564 1420.7020 -0.0457 0 25 0.13 1 K.LLETECPQYIR.K 37679 37689 37698 39435 775.3245 1548.6345 1548.7970 -0.1625 1 1 27 6 K.KLLETECPQYIR.K

162. P22528|SPR1B_HUMAN Mass: 10337 Score: 31 Queries matched: 3 emPAI: 0.93 Cornifin-B OS=Homo sapiens GN=SPRR1B PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24624 477.7242 953.4339 953.4641 -0.0301 0 34 0.016 1 K.VPEPCQPK.V 24923 482.2247 962.4349 962.4644 -0.0295 0 18 0.93 1 K.VPEPCHPK.V 24925

Proteins matching the same set of peptides: P35321|SPR1A_HUMAN Mass: 10327 Score: 31 Queries matched: 3 Cornifin-A OS=Homo sapiens GN=SPRR1A PE=1 SV=2

163. P29401|TKT_HUMAN Mass: 68519 Score: 30 Queries matched: 5 emPAI: 0.05 Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2200 422.2356 842.4566 842.4610 -0.0044 0 27 0.42 1 R.DAIAQAVR.G 24487 473.2588 944.5030 944.5179 -0.0148 0 30 0.064 1 R.IIALDGDTK.N

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2763 432.2876 1293.8411 1293.7768 0.0643 1 2 2.2e+002 1 R.VPRSGKPAELLK.M 2764 9282 551.2423 1650.7051 1650.7865 -0.0814 0 2 92 5 R.TVPFCSTFAAFFTR.A

164. P26038|MOES_HUMAN Mass: 67892 Score: 30 Queries matched: 17 emPAI: 0.05 Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1422 417.2351 832.4556 832.4694 -0.0138 0 16 6.4 1 K.ESPLLFK.F 25423 494.2454 986.4762 986.5032 -0.0270 0 30 0.056 1 R.ALELEQER.K 26975 523.2709 1044.5273 1044.5563 -0.0290 0 12 3.8 1 K.ALTSELANAR.D 29819 558.3145 1114.6144 1114.5982 0.0162 1 10 5 2 R.ALELEQERK.R 33131 616.2843 1230.5540 1230.5840 -0.0300 0 10 4.9 1 K.AQQELEEQTR.R 2981 435.2386 1302.6940 1302.6568 0.0372 1 0 2.1e+002 1 K.EVHKSGYLAGDK.L 3719 444.8706 1331.5899 1331.6755 -0.0856 0 5 18 4 R.KPDTIEVQQMK.A 3706 3707 3712 3713 3715 3716 3721 3723 3726 3

165. P21333|FLNA_HUMAN Mass: 283301 Score: 30 Queries matched: 9 emPAI: 0.01 Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8182 529.3197 528.3125 528.3020 0.0105 0 4 30 8 K.VTGPR.L 23946 463.2741 924.5337 924.5505 -0.0168 1 2 30 2 R.AVGRGLQPK.G 5293 465.7445 929.4745 929.5546 -0.0801 1 7 12 6 K.IKVSGLGEK.V 25461 494.7544 987.4943 987.5349 -0.0406 1 9 8.4 2 K.KGEITGEVR.M 29210 550.2452 1098.4759 1098.5669 -0.0910 0 0 47 3 K.GTVEPQLEAR.G 38033 721.8429 1441.6711 1441.6910 -0.0198 0 30 0.042 1 R.AGQSAAGAAPGGGVDTR.D 38087 722.8585 1443.7025 1443.7327 -0.0301 1 1 33 5 K.VKCSGPGLSPGMVR.A 10731 584.2751 1749.8035 1749.8727 -0.0691 0 2 69 4 R.TFSVWYVPEVTGTHK.V 46143 469.7304 2812.3386 2812.4218 -0.0832 1 8 3.1 5 K.YTPRGAGSYTIMVLFADQATPTSPIR.V

166. Q9P219|DAPLE_HUMAN Mass: 229215 Score: 30 Queries matched: 29 emPAI: 0.02 Protein Daple OS=Homo sapiens GN=CCDC88C PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13599 674.3612 673.3540 673.3759 -0.0219 1 2 60 2 K.EELRK.N 2529 428.2853 854.5560 854.4796 0.0764 0 8 17 1 R.SMVLHLR.R 20320 2524 2527 22723 441.2617 880.5088 880.4191 0.0897 0 2 27 2 K.EAWGPGHK.E 3585 442.7221 883.4297 883.4148 0.0149 0 10 4.4 3 R.DAHNGSVGK.G 24414 470.7674 939.5203 939.5138 0.0066 0 2 32 6 K.LGAPEALGGR.E 7432 517.7562 1033.4978 1033.4928 0.0050 0 4 22 4 K.DAVLDDSTAK.L 31968 594.3352 1186.6558 1186.6445 0.0113 0 4 22 9 R.EDNIILIETK.A 32444 603.8007 1205.5869 1205.6503 -0.0634 1 5 17 10 R.KVTSLETATEK.V 32425 32432 32436 32440 32442 33147 616.7543 1231.4940 1231.6230 -0.1291 0 2 26 2 K.AMLEEQLTAAR.A 33297 617.8318 1233.6491 1233.6275 0.0217 0 30 0.05 2 R.QLESELQMLK.K 33288 33290 33293 33294 33298 33299 33300 3330 35932 661.3056 1320.5967 1320.6231 -0.0264 0 5 14 1 K.EQLQSDMETLK.A 35928 10225 569.3073 1704.9000 1704.9060 -0.0060 1 1 1.1e+002 4 R.GELDRVNFLHHQLK.G

167. P13639|EF2_HUMAN Mass: 96246 Score: 30 Queries matched: 9 emPAI: 0.04 Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3781 445.7476 889.4806 889.5022 -0.0215 0 6 16 4 K.FSVSPVVR.V 25030 485.2730 968.5315 968.5403 -0.0089 0 7 9.2 1 R.GGGQIIPTAR.R 25963 503.7459 1005.4772 1005.4913 -0.0141 1 2 35 3 K.MVPTSDKGR.F 26032 507.2426 1012.4706 1012.4938 -0.0232 0 19 0.57 1 K.GEGQLGPAER.A 28871 545.3079 1088.6012 1088.6086 -0.0074 0 3 29 8 R.IKPVLMMNK.M 29009 546.2903 1090.5661 1090.5771 -0.0110 0 30 0.057 1 M.VNFTVDQIR.A 29253 551.7542 1101.4938 1101.5165 -0.0226 0 1 43 2 K.QFAEM YVAK.F 9402 553.2611 1104.5076 1104.6035 -0.0959 0 (2) 86 5 R.IKPVLMMNK.M 39031 752.3717 1502.7289 1502.7591 -0.0303 1 1 34 10 K.QFAEMYVAKFAAK.G

Mascot: http://www.matrixscience.com/

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Mascot Search Results

User : Email : Search title : Database : SwissProt 57.12 (513877 sequences; 180750753 residues) Taxonomy : Homo sapiens (human) (20329 sequences) Timestamp : 12 Feb 2010 at 14:20:36 GMT Enzyme : Trypsin Fixed modifications : Carbamidomethyl (C) Variable modifications : Oxidation (M) Mass values : Monoisotopic Protein Mass : Unrestricted Peptide Mass Tolerance : ± 0.2 Da Fragment Mass Tolerance: ± 0.2 Da Max Missed Cleavages : 1 Instrument type : ESI-QUAD-TOF Number of queries : 33463 Protein hits : P35908|K22E_HUMAN Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 P13645|K1C10_HUMAN Keratin, type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 P04264|K2C1_HUMAN Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 P35527|K1C9_HUMAN Keratin, type I cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 P02533|K1C14_HUMAN Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 P08670|VIME_HUMAN Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 P08779|K1C16_HUMAN Keratin, type I cytoskeletal 16 OS=Homo sapiens GN=KRT16 PE=1 SV=4 P13647|K2C5_HUMAN Keratin, type II cytoskeletal 5 OS=Homo sapiens GN=KRT5 PE=1 SV=3 P60709|ACTB_HUMAN Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 P04259|K2C6B_HUMAN Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 Q04695|K1C17_HUMAN Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 P13646|K1C13_HUMAN Keratin, type I cytoskeletal 13 OS=Homo sapiens GN=KRT13 PE=1 SV=4 P62736|ACTA_HUMAN Actin, aortic smooth muscle OS=Homo sapiens GN=ACTA2 PE=1 SV=1 P19012|K1C15_HUMAN Keratin, type I cytoskeletal 15 OS=Homo sapiens GN=KRT15 PE=1 SV=2 P02538|K2C6A_HUMAN Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 P19013|K2C4_HUMAN Keratin, type II cytoskeletal 4 OS=Homo sapiens GN=KRT4 PE=1 SV=4 P09467|F16P1_HUMAN Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=4 P63104|1433Z_HUMAN 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 P60174|TPIS_HUMAN Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=2 P21333|FLNA_HUMAN Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 Q7Z3Y8|K1C27_HUMAN Keratin, type I cytoskeletal 27 OS=Homo sapiens GN=KRT27 PE=1 SV=1 P40121|CAPG_HUMAN Macrophage-capping protein OS=Homo sapiens GN=CAPG PE=1 SV=1 P04406|G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 P07355|ANXA2_HUMAN Annexin A2 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 P04083|ANXA1_HUMAN Annexin A1 OS=Homo sapiens GN=ANXA1 PE=1 SV=2 P04075|ALDOA_HUMAN Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2 P00338|LDHA_HUMAN L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 O95678|K2C75_HUMAN Keratin, type II cytoskeletal 75 OS=Homo sapiens GN=KRT75 PE=1 SV=2 P07195|LDHB_HUMAN L-lactate dehydrogenase B chain OS=Homo sapiens GN=LDHB PE=1 SV=2 P05787|K2C8_HUMAN Keratin, type II cytoskeletal 8 OS=Homo sapiens GN=KRT8 PE=1 SV=7 P02649|APOE_HUMAN Apolipoprotein E OS=Homo sapiens GN=APOE PE=1 SV=1 P40925|MDHC_HUMAN Malate dehydrogenase, cytoplasmic OS=Homo sapiens GN=MDH1 PE=1 SV=4 P81605|DCD_HUMAN Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 P07737|PROF1_HUMAN Profilin-1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 O00299|CLIC1_HUMAN Chloride intracellular channel protein 1 OS=Homo sapiens GN=CLIC1 PE=1 SV=4 O76014|KRT37_HUMAN Keratin, type I cuticular Ha7 OS=Homo sapiens GN=KRT37 PE=2 SV=3 P05783|K1C18_HUMAN Keratin, type I cytoskeletal 18 OS=Homo sapiens GN=KRT18 PE=1 SV=2 O76013|KRT36_HUMAN Keratin, type I cuticular Ha6 OS=Homo sapiens GN=KRT36 PE=1 SV=1 P12035|K2C3_HUMAN Keratin, type II cytoskeletal 3 OS=Homo sapiens GN=KRT3 PE=1 SV=2 P06396|GELS_HUMAN Gelsolin OS=Homo sapiens GN=GSN PE=1 SV=1 P52566|GDIR2_HUMAN Rho GDP-dissociation inhibitor 2 OS=Homo sapiens GN=ARHGDIB PE=1 SV=3 P62258|1433E_HUMAN 14-3-3 protein epsilon OS=Homo sapiens GN=YWHAE PE=1 SV=1 Q06830|PRDX1_HUMAN Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 P41219|PERI_HUMAN Peripherin OS=Homo sapiens GN=PRPH PE=1 SV=2 P08758|ANXA5_HUMAN Annexin A5 OS=Homo sapiens GN=ANXA5 PE=1 SV=2 P61981|1433G_HUMAN 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 Q99456|K1C12_HUMAN Keratin, type I cytoskeletal 12 OS=Homo sapiens GN=KRT12 PE=1 SV=1 P06733|ENOA_HUMAN Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 O00757|F16P2_HUMAN Fructose-1,6-bisphosphatase isozyme 2 OS=Homo sapiens GN=FBP2 PE=1 SV=2 P61626|LYSC_HUMAN Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 Q5VTE0|EF1A3_HUMAN Putative elongation factor 1-alpha-like 3 OS=Homo sapiens GN=EEF1AL3 PE=5 SV=1 P13796|PLSL_HUMAN Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=5 Q7Z794|K2C1B_HUMAN Keratin, type II cytoskeletal 1b OS=Homo sapiens GN=KRT77 PE=1 SV=2 P27348|1433T_HUMAN 14-3-3 protein theta OS=Homo sapiens GN=YWHAQ PE=1 SV=1 P11142|HSP7C_HUMAN Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 P37837|TALDO_HUMAN Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 Q5XKE5|K2C79_HUMAN Keratin, type II cytoskeletal 79 OS=Homo sapiens GN=KRT79 PE=1 SV=1 P31946|1433B_HUMAN 14-3-3 protein beta/alpha OS=Homo sapiens GN=YWHAB PE=1 SV=3 P26038|MOES_HUMAN Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 P14618|KPYM_HUMAN Pyruvate kinase isozymes M1/M2 OS=Homo sapiens GN=PKM2 PE=1 SV=4 Q9NSB2|KRT84_HUMAN Keratin, type II cuticular Hb4 OS=Homo sapiens GN=KRT84 PE=1 SV=1 P00918|CAH2_HUMAN Carbonic anhydrase 2 OS=Homo sapiens GN=CA2 PE=1 SV=2 P07864|LDHC_HUMAN L-lactate dehydrogenase C chain OS=Homo sapiens GN=LDHC PE=2 SV=4 P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3 P07197|NFM_HUMAN Neurofilament medium polypeptide OS=Homo sapiens GN=NEFM PE=1 SV=3 P23528|COF1_HUMAN Cofilin-1 OS=Homo sapiens GN=CFL1 PE=1 SV=3 P15924|DESP_HUMAN Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 Q8N1N4|K2C78_HUMAN Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=1 SV=2 P60660|MYL6_HUMAN Myosin light polypeptide 6 OS=Homo sapiens GN=MYL6 PE=1 SV=2 P37802|TAGL2_HUMAN Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 P02768|ALBU_HUMAN Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 P62937|PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens GN=PPIA PE=1 SV=2 P08107|HSP71_HUMAN Heat shock 70 kDa protein 1 OS=Homo sapiens GN=HSPA1A PE=1 SV=5

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P08238|HS90B_HUMAN Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4 Q9H299|SH3L3_HUMAN SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 O15511|ARPC5_HUMAN Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens GN=ARPC5 PE=1 SV=3 P22392|NDKB_HUMAN Nucleoside diphosphate kinase B OS=Homo sapiens GN=NME2 PE=1 SV=1 P54652|HSP72_HUMAN Heat shock-related 70 kDa protein 2 OS=Homo sapiens GN=HSPA2 PE=1 SV=1 Q3SY84|K2C71_HUMAN Keratin, type II cytoskeletal 71 OS=Homo sapiens GN=KRT71 PE=1 SV=2 P67936|TPM4_HUMAN Tropomyosin alpha-4 chain OS=Homo sapiens GN=TPM4 PE=1 SV=3 P62988|UBIQ_HUMAN Ubiquitin OS=Homo sapiens GN=RPS27A PE=1 SV=1 P36222|CH3L1_HUMAN Chitinase-3-like protein 1 OS=Homo sapiens GN=CHI3L1 PE=1 SV=2 Q9UL46|PSME2_HUMAN Proteasome activator complex subunit 2 OS=Homo sapiens GN=PSME2 PE=1 SV=3 P78417|GSTO1_HUMAN Glutathione S-transferase omega-1 OS=Homo sapiens GN=GSTO1 PE=1 SV=2 Q01469|FABP5_HUMAN Fatty acid-binding protein, epidermal OS=Homo sapiens GN=FABP5 PE=1 SV=3 Q09666|AHNK_HUMAN Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens GN=AHNAK PE=1 SV=2 P32119|PRDX2_HUMAN Peroxiredoxin-2 OS=Homo sapiens GN=PRDX2 PE=1 SV=5 P62805|H4_HUMAN Histone H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 P52907|CAZA1_HUMAN F-actin-capping protein subunit alpha-1 OS=Homo sapiens GN=CAPZA1 PE=1 SV=3 P00558|PGK1_HUMAN Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 PE=1 SV=3 Q5D862|FILA2_HUMAN Filaggrin-2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 P02545|LMNA_HUMAN Lamin-A/C OS=Homo sapiens GN=LMNA PE=1 SV=1 P04080|CYTB_HUMAN Cystatin-B OS=Homo sapiens GN=CSTB PE=1 SV=2 P07602|SAP_HUMAN Proactivator polypeptide OS=Homo sapiens GN=PSAP PE=1 SV=2 P15121|ALDR_HUMAN Aldose reductase OS=Homo sapiens GN=AKR1B1 PE=1 SV=3 P09493|TPM1_HUMAN Tropomyosin alpha-1 chain OS=Homo sapiens GN=TPM1 PE=1 SV=2 P07951|TPM2_HUMAN Tropomyosin beta chain OS=Homo sapiens GN=TPM2 PE=1 SV=1 O75368|SH3L1_HUMAN SH3 domain-binding glutamic acid-rich-like protein OS=Homo sapiens GN=SH3BGRL PE=1 SV=1 Q14019|COTL1_HUMAN Coactosin-like protein OS=Homo sapiens GN=COTL1 PE=1 SV=3 P29401|TKT_HUMAN Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 P99999|CYC_HUMAN Cytochrome c OS=Homo sapiens GN=CYCS PE=1 SV=2 P25774|CATS_HUMAN Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 P08865|RSSA_HUMAN 40S ribosomal protein SA OS=Homo sapiens GN=RPSA PE=1 SV=4 P02786|TFR1_HUMAN Transferrin receptor protein 1 OS=Homo sapiens GN=TFRC PE=1 SV=2 P05109|S10A8_HUMAN Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 P14649|MYL6B_HUMAN Myosin light chain 6B OS=Homo sapiens GN=MYL6B PE=1 SV=1 P61769|B2MG_HUMAN Beta-2-microglobulin OS=Homo sapiens GN=B2M PE=1 SV=1 P10599|THIO_HUMAN Thioredoxin OS=Homo sapiens GN=TXN PE=1 SV=3 P06703|S10A6_HUMAN Protein S100-A6 OS=Homo sapiens GN=S100A6 PE=1 SV=1 Q5VSK2|MRC1L_HUMAN Macrophage mannose receptor 1-like protein 1 OS=Homo sapiens GN=MRC1L1 PE=2 SV=1 P14550|AK1A1_HUMAN Alcohol dehydrogenase [NADP+] OS=Homo sapiens GN=AKR1A1 PE=1 SV=3 P29373|RABP2_HUMAN Cellular retinoic acid-binding protein 2 OS=Homo sapiens GN=CRABP2 PE=1 SV=2 Q04917|1433F_HUMAN 14-3-3 protein eta OS=Homo sapiens GN=YWHAH PE=1 SV=4 Q96C19|EFHD2_HUMAN EF-hand domain-containing protein D2 OS=Homo sapiens GN=EFHD2 PE=1 SV=1 P62826|RAN_HUMAN GTP-binding nuclear protein Ran OS=Homo sapiens GN=RAN PE=1 SV=3 P26447|S10A4_HUMAN Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1 P25788|PSA3_HUMAN Proteasome subunit alpha type-3 OS=Homo sapiens GN=PSMA3 PE=1 SV=2 Q86UX7|URP2_HUMAN Fermitin family homolog 3 OS=Homo sapiens GN=FERMT3 PE=1 SV=1 P31949|S10AB_HUMAN Protein S100-A11 OS=Homo sapiens GN=S100A11 PE=1 SV=2 P11021|GRP78_HUMAN 78 kDa glucose-regulated protein OS=Homo sapiens GN=HSPA5 PE=1 SV=2 P18669|PGAM1_HUMAN Phosphoglycerate mutase 1 OS=Homo sapiens GN=PGAM1 PE=1 SV=2 P17900|SAP3_HUMAN Ganglioside GM2 activator OS=Homo sapiens GN=GM2A PE=1 SV=4 P01876|IGHA1_HUMAN Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 P52790|HXK3_HUMAN Hexokinase-3 OS=Homo sapiens GN=HK3 PE=1 SV=2 P13489|RINI_HUMAN Ribonuclease inhibitor OS=Homo sapiens GN=RNH1 PE=1 SV=2 P09382|LEG1_HUMAN Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 P31947|1433S_HUMAN 14-3-3 protein sigma OS=Homo sapiens GN=SFN PE=1 SV=1 P06753|TPM3_HUMAN Tropomyosin alpha-3 chain OS=Homo sapiens GN=TPM3 PE=1 SV=1 P30050|RL12_HUMAN 60S ribosomal protein L12 OS=Homo sapiens GN=RPL12 PE=1 SV=1 P15259|PGAM2_HUMAN Phosphoglycerate mutase 2 OS=Homo sapiens GN=PGAM2 PE=1 SV=3 P59998|ARPC4_HUMAN Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens GN=ARPC4 PE=1 SV=3 P02787|TRFE_HUMAN Serotransferrin OS=Homo sapiens GN=TF PE=1 SV=2 A8MW06|TMSL3_HUMAN Thymosin beta-4-like protein 3 OS=Homo sapiens GN=TMSL3 PE=2 SV=1 Q5JXB2|UE2NL_HUMAN Putative ubiquitin-conjugating enzyme E2 N-like OS=Homo sapiens GN=UBE2NL PE=5 SV=1 P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 P63244|GBLP_HUMAN Guanine nucleotide-binding protein subunit beta-2-like 1 OS=Homo sapiens GN=GNB2L1 PE=1 SV=3 P28072|PSB6_HUMAN Proteasome subunit beta type-6 OS=Homo sapiens GN=PSMB6 PE=1 SV=4 O60234|GMFG_HUMAN Glia maturation factor gamma OS=Homo sapiens GN=GMFG PE=1 SV=1 P62807|H2B1C_HUMAN Histone H2B type 1-C/E/F/G/I OS=Homo sapiens GN=HIST1H2BC PE=1 SV=3 Q15149|PLEC1_HUMAN Plectin-1 OS=Homo sapiens GN=PLEC1 PE=1 SV=3 Q9Y490|TLN1_HUMAN Talin-1 OS=Homo sapiens GN=TLN1 PE=1 SV=3 P11215|ITAM_HUMAN Integrin alpha-M OS=Homo sapiens GN=ITGAM PE=1 SV=2 P15090|FABP4_HUMAN Fatty acid-binding protein, adipocyte OS=Homo sapiens GN=FABP4 PE=1 SV=3 Q6EEV6|SUMO4_HUMAN Small ubiquitin-related modifier 4 OS=Homo sapiens GN=SUMO4 PE=1 SV=2 O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens GN=IDH1 PE=1 SV=2 A8MT79|ZAGL1_HUMAN Putative zinc-alpha-2-glycoprotein-like 1 OS=Homo sapiens PE=5 SV=2 P61026|RAB10_HUMAN Ras-related protein Rab-10 OS=Homo sapiens GN=RAB10 PE=1 SV=1 P30041|PRDX6_HUMAN Peroxiredoxin-6 OS=Homo sapiens GN=PRDX6 PE=1 SV=3 P47755|CAZA2_HUMAN F-actin-capping protein subunit alpha-2 OS=Homo sapiens GN=CAPZA2 PE=1 SV=3 P18206|VINC_HUMAN Vinculin OS=Homo sapiens GN=VCL PE=1 SV=4 P52565|GDIR1_HUMAN Rho GDP-dissociation inhibitor 1 OS=Homo sapiens GN=ARHGDIA PE=1 SV=3 P40926|MDHM_HUMAN Malate dehydrogenase, mitochondrial OS=Homo sapiens GN=MDH2 PE=1 SV=3 O15143|ARC1B_HUMAN Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens GN=ARPC1B PE=1 SV=3 Q71UI9|H2AV_HUMAN Histone H2A.V OS=Homo sapiens GN=H2AFV PE=1 SV=3 P60842|IF4A1_HUMAN Eukaryotic initiation factor 4A-I OS=Homo sapiens GN=EIF4A1 PE=1 SV=1 P58546|MTPN_HUMAN Myotrophin OS=Homo sapiens GN=MTPN PE=1 SV=2 O00182|LEG9_HUMAN Galectin-9 OS=Homo sapiens GN=LGALS9 PE=1 SV=2 Q9H4G4|GAPR1_HUMAN Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens GN=GLIPR2 PE=1 SV=3 Q14533|KRT81_HUMAN Keratin, type II cuticular Hb1 OS=Homo sapiens GN=KRT81 PE=1 SV=2 Q15365|PCBP1_HUMAN Poly(rC)-binding protein 1 OS=Homo sapiens GN=PCBP1 PE=1 SV=2 P61604|CH10_HUMAN 10 kDa heat shock protein, mitochondrial OS=Homo sapiens GN=HSPE1 PE=1 SV=2 P60983|GMFB_HUMAN Glia maturation factor beta OS=Homo sapiens GN=GMFB PE=1 SV=2

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P06748|NPM_HUMAN Nucleophosmin OS=Homo sapiens GN=NPM1 PE=1 SV=2 Q71DI3|H32_HUMAN Histone H3.2 OS=Homo sapiens GN=HIST2H3A PE=1 SV=3 Q01105|SET_HUMAN Protein SET OS=Homo sapiens GN=SET PE=1 SV=3 P25398|RS12_HUMAN 40S ribosomal protein S12 OS=Homo sapiens GN=RPS12 PE=1 SV=3 P62820|RAB1A_HUMAN Ras-related protein Rab-1A OS=Homo sapiens GN=RAB1A PE=1 SV=3 P78386|KRT85_HUMAN Keratin, type II cuticular Hb5 OS=Homo sapiens GN=KRT85 PE=1 SV=1 P60900|PSA6_HUMAN Proteasome subunit alpha type-6 OS=Homo sapiens GN=PSMA6 PE=1 SV=1 P10768|ESTD_HUMAN S-formylglutathione hydrolase OS=Homo sapiens GN=ESD PE=1 SV=2 O14818|PSA7_HUMAN Proteasome subunit alpha type-7 OS=Homo sapiens GN=PSMA7 PE=1 SV=1 P47756|CAPZB_HUMAN F-actin-capping protein subunit beta OS=Homo sapiens GN=CAPZB PE=1 SV=4 P53004|BIEA_HUMAN Biliverdin reductase A OS=Homo sapiens GN=BLVRA PE=1 SV=2 P30273|FCERG_HUMAN High affinity immunoglobulin epsilon receptor subunit gamma OS=Homo sapiens GN=FCER1G PE=1 S Q00610|CLH1_HUMAN Clathrin heavy chain 1 OS=Homo sapiens GN=CLTC PE=1 SV=5 Q14847|LASP1_HUMAN LIM and SH3 domain protein 1 OS=Homo sapiens GN=LASP1 PE=1 SV=2 P28065|PSB9_HUMAN Proteasome subunit beta type-9 OS=Homo sapiens GN=PSMB9 PE=1 SV=2 P51149|RAB7A_HUMAN Ras-related protein Rab-7a OS=Homo sapiens GN=RAB7A PE=1 SV=1 P15144|AMPN_HUMAN Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 P35241|RADI_HUMAN Radixin OS=Homo sapiens GN=RDX PE=1 SV=1 O75348|VATG1_HUMAN V-type proton ATPase subunit G 1 OS=Homo sapiens GN=ATP6V1G1 PE=1 SV=3 P50395|GDIB_HUMAN Rab GDP dissociation inhibitor beta OS=Homo sapiens GN=GDI2 PE=1 SV=2 Q9Y696|CLIC4_HUMAN Chloride intracellular channel protein 4 OS=Homo sapiens GN=CLIC4 PE=1 SV=4 P17931|LEG3_HUMAN Galectin-3 OS=Homo sapiens GN=LGALS3 PE=1 SV=5 Q8IUE6|H2A2B_HUMAN Histone H2A type 2-B OS=Homo sapiens GN=HIST2H2AB PE=1 SV=3 P35754|GLRX1_HUMAN Glutaredoxin-1 OS=Homo sapiens GN=GLRX PE=1 SV=2 P20702|ITAX_HUMAN Integrin alpha-X OS=Homo sapiens GN=ITGAX PE=1 SV=3 P46940|IQGA1_HUMAN Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens GN=IQGAP1 PE=1 SV=1 P61224|RAP1B_HUMAN Ras-related protein Rap-1b OS=Homo sapiens GN=RAP1B PE=1 SV=1 Q14103|HNRPD_HUMAN Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens GN=HNRNPD PE=1 SV=1 Q15942|ZYX_HUMAN Zyxin OS=Homo sapiens GN=ZYX PE=1 SV=1 P05413|FABPH_HUMAN Fatty acid-binding protein, heart OS=Homo sapiens GN=FABP3 PE=1 SV=4 P13639|EF2_HUMAN Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4 P05388|RLA0_HUMAN 60S acidic ribosomal protein P0 OS=Homo sapiens GN=RPLP0 PE=1 SV=1 Q9BRF8|CPPED_HUMAN Calcineurin-like phosphoesterase domain-containing protein 1 OS=Homo sapiens GN=CPPED1 PE=1 P23396|RS3_HUMAN 40S ribosomal protein S3 OS=Homo sapiens GN=RPS3 PE=1 SV=2 P15153|RAC2_HUMAN Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens GN=RAC2 PE=1 SV=1 P25786|PSA1_HUMAN Proteasome subunit alpha type-1 OS=Homo sapiens GN=PSMA1 PE=1 SV=1 P09211|GSTP1_HUMAN Glutathione S-transferase P OS=Homo sapiens GN=GSTP1 PE=1 SV=2 P30613|KPYR_HUMAN Pyruvate kinase isozymes R/L OS=Homo sapiens GN=PKLR PE=1 SV=2 P15311|EZRI_HUMAN Ezrin OS=Homo sapiens GN=EZR PE=1 SV=4 Q99497|PARK7_HUMAN Protein DJ-1 OS=Homo sapiens GN=PARK7 PE=1 SV=2 P29350|PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens GN=PTPN6 PE=1 SV=1 Q8TER0|SNED1_HUMAN Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens GN=SNED1 PE=1 SV=2 P12814|ACTN1_HUMAN Alpha-actinin-1 OS=Homo sapiens GN=ACTN1 PE=1 SV=2 P18085|ARF4_HUMAN ADP-ribosylation factor 4 OS=Homo sapiens GN=ARF4 PE=1 SV=3 Q9UJ70|NAGK_HUMAN N-acetyl-D-glucosamine kinase OS=Homo sapiens GN=NAGK PE=1 SV=4 Q14344|GNA13_HUMAN Guanine nucleotide-binding protein subunit alpha-13 OS=Homo sapiens GN=GNA13 PE=1 SV=2 Q03113|GNA12_HUMAN Guanine nucleotide-binding protein subunit alpha-12 OS=Homo sapiens GN=GNA12 PE=1 SV=4 P38405|GNAL_HUMAN Guanine nucleotide-binding protein G(olf) subunit alpha OS=Homo sapiens GN=GNAL PE=1 SV=1 P04899|GNAI2_HUMAN Guanine nucleotide-binding protein G(i), alpha-2 subunit OS=Homo sapiens GN=GNAI2 PE=1 SV=3 P11488|GNAT1_HUMAN Guanine nucleotide-binding protein G(t) subunit alpha-1 OS=Homo sapiens GN=GNAT1 PE=1 SV=5 Q8N1A0|KT222_HUMAN Keratin-like protein KRT222 OS=Homo sapiens GN=KRT222 PE=2 SV=1 P19338|NUCL_HUMAN Nucleolin OS=Homo sapiens GN=NCL PE=1 SV=3 P35579|MYH9_HUMAN Myosin-9 OS=Homo sapiens GN=MYH9 PE=1 SV=4 P54819|KAD2_HUMAN Adenylate kinase 2, mitochondrial OS=Homo sapiens GN=AK2 PE=1 SV=2 P62873|GBB1_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens GN=GNB1 PE= P62942|FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens GN=FKBP1A PE=1 SV=2 P47929|LEG7_HUMAN Galectin-7 OS=Homo sapiens GN=LGALS7 PE=1 SV=2 P05107|ITB2_HUMAN Integrin beta-2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 P29692|EF1D_HUMAN Elongation factor 1-delta OS=Homo sapiens GN=EEF1D PE=1 SV=5 P30044|PRDX5_HUMAN Peroxiredoxin-5, mitochondrial OS=Homo sapiens GN=PRDX5 PE=1 SV=3 Q9NSB4|KRT82_HUMAN Keratin, type II cuticular Hb2 OS=Homo sapiens GN=KRT82 PE=1 SV=3 P62993|GRB2_HUMAN Growth factor receptor-bound protein 2 OS=Homo sapiens GN=GRB2 PE=1 SV=1 Q15121|PEA15_HUMAN Astrocytic phosphoprotein PEA-15 OS=Homo sapiens GN=PEA15 PE=1 SV=2 P00491|PNPH_HUMAN Purine nucleoside phosphorylase OS=Homo sapiens GN=NP PE=1 SV=2 P30086|PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens GN=PEBP1 PE=1 SV=3 P04839|CY24B_HUMAN Cytochrome b-245 heavy chain OS=Homo sapiens GN=CYBB PE=1 SV=2 Q13835|PKP1_HUMAN Plakophilin-1 OS=Homo sapiens GN=PKP1 PE=1 SV=2 O00175|CCL24_HUMAN C-C motif chemokine 24 OS=Homo sapiens GN=CCL24 PE=1 SV=2 O95336|6PGL_HUMAN 6-phosphogluconolactonase OS=Homo sapiens GN=PGLS PE=1 SV=2 P39019|RS19_HUMAN 40S ribosomal protein S19 OS=Homo sapiens GN=RPS19 PE=1 SV=2 P22314|UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3 P60903|S10AA_HUMAN Protein S100-A10 OS=Homo sapiens GN=S100A10 PE=1 SV=2 P39687|AN32A_HUMAN Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens GN=ANP32A PE=1 Q9NRV9|HEBP1_HUMAN Heme-binding protein 1 OS=Homo sapiens GN=HEBP1 PE=1 SV=1 P20962|PTMS_HUMAN Parathymosin OS=Homo sapiens GN=PTMS PE=1 SV=2 Q7Z6K2|TPISL_HUMAN Putative triosephosphate isomerase-like protein LOC286016 OS=Homo sapiens PE=1 SV=2 P60763|RAC3_HUMAN Ras-related C3 botulinum toxin substrate 3 OS=Homo sapiens GN=RAC3 PE=1 SV=1 P38646|GRP75_HUMAN Stress-70 protein, mitochondrial OS=Homo sapiens GN=HSPA9 PE=1 SV=2 P09327|VILI_HUMAN Villin-1 OS=Homo sapiens GN=VIL1 PE=1 SV=4 O76011|KRT34_HUMAN Keratin, type I cuticular Ha4 OS=Homo sapiens GN=KRT34 PE=1 SV=2 Q9NQC3|RTN4_HUMAN Reticulon-4 OS=Homo sapiens GN=RTN4 PE=1 SV=2 O94903|PROSC_HUMAN Proline synthetase co-transcribed bacterial homolog protein OS=Homo sapiens GN=PROSC PE=1 SV P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens GN=HNRNPA2B1 PE=1 SV=2 Q9UK45|LSM7_HUMAN U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens GN=LSM7 PE=1 SV=1 Q6A162|K1C40_HUMAN Keratin, type I cytoskeletal 40 OS=Homo sapiens GN=KRT40 PE=1 SV=2 Q9C075|K1C23_HUMAN Keratin, type I cytoskeletal 23 OS=Homo sapiens GN=KRT23 PE=1 SV=2 P02452|CO1A1_HUMAN Collagen alpha-1(I) chain OS=Homo sapiens GN=COL1A1 PE=1 SV=4 P31146|COR1A_HUMAN Coronin-1A OS=Homo sapiens GN=CORO1A PE=1 SV=4 P27695|APEX1_HUMAN DNA-(apurinic or apyrimidinic site) lyase OS=Homo sapiens GN=APEX1 PE=1 SV=2

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P15586|GNS_HUMAN N-acetylglucosamine-6-sulfatase OS=Homo sapiens GN=GNS PE=1 SV=3 Q8WZ42|TITIN_HUMAN Titin OS=Homo sapiens GN=TTN PE=1 SV=2 Q13404|UB2V1_HUMAN Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens GN=UBE2V1 PE=1 SV=2 P01034|CYTC_HUMAN Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1 P14780|MMP9_HUMAN Matrix metalloproteinase-9 OS=Homo sapiens GN=MMP9 PE=1 SV=3 P20700|LMNB1_HUMAN Lamin-B1 OS=Homo sapiens GN=LMNB1 PE=1 SV=2 P20674|COX5A_HUMAN Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens GN=COX5A PE=1 SV=2 P07476|INVO_HUMAN Involucrin OS=Homo sapiens GN=IVL PE=1 SV=2 Q15819|UB2V2_HUMAN Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens GN=UBE2V2 PE=1 SV=4 P16070|CD44_HUMAN CD44 antigen OS=Homo sapiens GN=CD44 PE=1 SV=2 P15880|RS2_HUMAN 40S ribosomal protein S2 OS=Homo sapiens GN=RPS2 PE=1 SV=2 P46926|GNPI1_HUMAN Glucosamine-6-phosphate isomerase 1 OS=Homo sapiens GN=GNPDA1 PE=1 SV=1 P49327|FAS_HUMAN Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 Q14315|FLNC_HUMAN Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 O43933|PEX1_HUMAN Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 P61916|NPC2_HUMAN Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 Q9UBG3|CRNN_HUMAN Cornulin OS=Homo sapiens GN=CRNN PE=1 SV=1 P06702|S10A9_HUMAN Protein S100-A9 OS=Homo sapiens GN=S100A9 PE=1 SV=1 P41250|SYG_HUMAN Glycyl-tRNA synthetase OS=Homo sapiens GN=GARS PE=1 SV=2 Q96C23|GALM_HUMAN Aldose 1-epimerase OS=Homo sapiens GN=GALM PE=1 SV=1 P09496|CLCA_HUMAN Clathrin light chain A OS=Homo sapiens GN=CLTA PE=1 SV=1 Q53RD9|FBLN7_HUMAN Fibulin-7 OS=Homo sapiens GN=FBLN7 PE=2 SV=1 P22061|PIMT_HUMAN Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=1 SV=3 Q96KP4|CNDP2_HUMAN Cytosolic non-specific dipeptidase OS=Homo sapiens GN=CNDP2 PE=1 SV=2 P25789|PSA4_HUMAN Proteasome subunit alpha type-4 OS=Homo sapiens GN=PSMA4 PE=1 SV=1 O15078|CE290_HUMAN Centrosomal protein of 290 kDa OS=Homo sapiens GN=CEP290 PE=1 SV=2 P49773|HINT1_HUMAN Histidine triad nucleotide-binding protein 1 OS=Homo sapiens GN=HINT1 PE=1 SV=2 P21926|CD9_HUMAN CD9 antigen OS=Homo sapiens GN=CD9 PE=1 SV=4 P07339|CATD_HUMAN Cathepsin D OS=Homo sapiens GN=CTSD PE=1 SV=1 P61077|UB2D3_HUMAN Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens GN=UBE2D3 PE=1 SV=1 P06454|PTMA_HUMAN Prothymosin alpha OS=Homo sapiens GN=PTMA PE=1 SV=2 O95372|LYPA2_HUMAN Acyl-protein thioesterase 2 OS=Homo sapiens GN=LYPLA2 PE=1 SV=1 P30740|ILEU_HUMAN Leukocyte elastase inhibitor OS=Homo sapiens GN=SERPINB1 PE=1 SV=1 Q96QK1|VPS35_HUMAN Vacuolar protein sorting-associated protein 35 OS=Homo sapiens GN=VPS35 PE=1 SV=2 P61313|RL15_HUMAN 60S ribosomal protein L15 OS=Homo sapiens GN=RPL15 PE=1 SV=2 P14923|PLAK_HUMAN Junction plakoglobin OS=Homo sapiens GN=JUP PE=1 SV=3 Q9HAB8|PPCS_HUMAN Phosphopantothenate--cysteine ligase OS=Homo sapiens GN=PPCS PE=1 SV=2 P55884|EIF3B_HUMAN Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens GN=EIF3B PE=1 SV=3 Q5T749|KPRP_HUMAN Keratinocyte proline-rich protein OS=Homo sapiens GN=KPRP PE=1 SV=1 P07437|TBB5_HUMAN Tubulin beta chain OS=Homo sapiens GN=TUBB PE=1 SV=2 Q86YZ3|HORN_HUMAN Hornerin OS=Homo sapiens GN=HRNR PE=1 SV=2 P30475|1B39_HUMAN HLA class I histocompatibility antigen, B-39 alpha chain OS=Homo sapiens GN=HLA-B PE=2 SV=1 Q95604|1C17_HUMAN HLA class I histocompatibility antigen, Cw-17 alpha chain OS=Homo sapiens GN=HLA-C PE=1 SV=1 P16152|CBR1_HUMAN Carbonyl reductase [NADPH] 1 OS=Homo sapiens GN=CBR1 PE=1 SV=3 Q15907|RB11B_HUMAN Ras-related protein Rab-11B OS=Homo sapiens GN=RAB11B PE=1 SV=4 P02778|CXL10_HUMAN C-X-C motif chemokine 10 OS=Homo sapiens GN=CXCL10 PE=1 SV=2 O75347|TBCA_HUMAN Tubulin-specific chaperone A OS=Homo sapiens GN=TBCA PE=1 SV=3 Q9HC38|GLOD4_HUMAN Glyoxalase domain-containing protein 4 OS=Homo sapiens GN=GLOD4 PE=1 SV=1 P50552|VASP_HUMAN Vasodilator-stimulated phosphoprotein OS=Homo sapiens GN=VASP PE=1 SV=3 P49207|RL34_HUMAN 60S ribosomal protein L34 OS=Homo sapiens GN=RPL34 PE=1 SV=3 P22307|NLTP_HUMAN Non-specific lipid-transfer protein OS=Homo sapiens GN=SCP2 PE=1 SV=2 P80075|CCL8_HUMAN C-C motif chemokine 8 OS=Homo sapiens GN=CCL8 PE=1 SV=2 Q8TF72|SHRM3_HUMAN Protein Shroom3 OS=Homo sapiens GN=SHROOM3 PE=1 SV=1 P10109|ADX_HUMAN Adrenodoxin, mitochondrial OS=Homo sapiens GN=FDX1 PE=1 SV=1 Q15643|TRIPB_HUMAN Thyroid receptor-interacting protein 11 OS=Homo sapiens GN=TRIP11 PE=1 SV=2 P18510|IL1RA_HUMAN Interleukin-1 receptor antagonist protein OS=Homo sapiens GN=IL1RN PE=1 SV=1 Q9H3K6|BOLA2_HUMAN BolA-like protein 2 OS=Homo sapiens GN=BOLA2 PE=1 SV=1 P04792|HSPB1_HUMAN Heat shock protein beta-1 OS=Homo sapiens GN=HSPB1 PE=1 SV=2 Q14956|GPNMB_HUMAN Transmembrane glycoprotein NMB OS=Homo sapiens GN=GPNMB PE=1 SV=2 P08648|ITA5_HUMAN Integrin alpha-5 OS=Homo sapiens GN=ITGA5 PE=1 SV=2 P13498|CY24A_HUMAN Cytochrome b-245 light chain OS=Homo sapiens GN=CYBA PE=1 SV=2 Q5JNZ5|RS26L_HUMAN Putative 40S ribosomal protein S26-like 1 OS=Homo sapiens GN=RPS26P11 PE=5 SV=1 Q99575|POP1_HUMAN Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens GN=POP1 PE=1 SV=2 Q9NTJ3|SMC4_HUMAN Structural maintenance of protein 4 OS=Homo sapiens GN=SMC4 PE=1 SV=2 P23526|SAHH_HUMAN Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4 P04440|DPB1_HUMAN HLA class II histocompatibility antigen, DP beta 1 chain OS=Homo sapiens GN=HLA-DPB1 PE=2 SV P01918|HB21_HUMAN HLA class II histocompatibility antigen, DQ(1) beta chain OS=Homo sapiens GN=HLA-DQB1 PE=1 S P42224|STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens GN=STAT1 PE=1 P28482|MK01_HUMAN Mitogen-activated protein kinase 1 OS=Homo sapiens GN=MAPK1 PE=1 SV=3 P62701|RS4X_HUMAN 40S ribosomal protein S4, X isoform OS=Homo sapiens GN=RPS4X PE=1 SV=2 P01040|CYTA_HUMAN Cystatin-A OS=Homo sapiens GN=CSTA PE=1 SV=1 P28066|PSA5_HUMAN Proteasome subunit alpha type-5 OS=Homo sapiens GN=PSMA5 PE=1 SV=3 Q15369|ELOC_HUMAN Transcription elongation factor B polypeptide 1 OS=Homo sapiens GN=TCEB1 PE=1 SV=1 A8K2U0|A2ML1_HUMAN Alpha-2-macroglobulin-like protein 1 OS=Homo sapiens GN=A2ML1 PE=1 SV=2 O15144|ARPC2_HUMAN Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens GN=ARPC2 PE=1 SV=1 Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 OS=Homo sapiens GN=CDC37 PE=1 SV=1 O43150|ASAP2_HUMAN Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens GN=AS Q15648|MED1_HUMAN Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens GN=MED1 PE=1 SV=4 P46781|RS9_HUMAN 40S ribosomal protein S9 OS=Homo sapiens GN=RPS9 PE=1 SV=3 O14647|CHD2_HUMAN Chromodomain-helicase-DNA-binding protein 2 OS=Homo sapiens GN=CHD2 PE=1 SV=2 P16402|H13_HUMAN Histone H1.3 OS=Homo sapiens GN=HIST1H1D PE=1 SV=2 P10412|H14_HUMAN Histone H1.4 OS=Homo sapiens GN=HIST1H1E PE=1 SV=2 P16403|H12_HUMAN Histone H1.2 OS=Homo sapiens GN=HIST1H1C PE=1 SV=2 P68036|UB2L3_HUMAN Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens GN=UBE2L3 PE=1 SV=1 Q9UQ80|PA2G4_HUMAN Proliferation-associated protein 2G4 OS=Homo sapiens GN=PA2G4 PE=1 SV=3 P02654|APOC1_HUMAN Apolipoprotein C-I OS=Homo sapiens GN=APOC1 PE=1 SV=1 Q96PE2|ARHGH_HUMAN Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 Q86U44|MTA70_HUMAN N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3 PE=1 SV=2 Q5VSP4|LC1L1_HUMAN Putative lipocalin 1-like protein 1 OS=Homo sapiens GN=LCN1L1 PE=5 SV=1

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P11279|LAMP1_HUMAN Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens GN=LAMP1 PE=1 SV=3 P63220|RS21_HUMAN 40S ribosomal protein S21 OS=Homo sapiens GN=RPS21 PE=1 SV=1 P51572|BAP31_HUMAN B-cell receptor-associated protein 31 OS=Homo sapiens GN=BCAP31 PE=1 SV=3 P09960|LKHA4_HUMAN Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 Q5T750|XP32_HUMAN Skin-specific protein 32 OS=Homo sapiens GN=XP32 PE=1 SV=1 Q9H972|CN093_HUMAN Uncharacterized protein C14orf93 OS=Homo sapiens GN=C14orf93 PE=2 SV=1 Q02413|DSG1_HUMAN Desmoglein-1 OS=Homo sapiens GN=DSG1 PE=1 SV=1 Q96QA5|GSDMA_HUMAN Gasdermin-A OS=Homo sapiens GN=GSDMA PE=2 SV=3 O14979|HNRDL_HUMAN Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens GN=HNRPDL PE=1 SV=3 Q8NEZ4|MLL3_HUMAN Histone-lysine N-methyltransferase MLL3 OS=Homo sapiens GN=MLL3 PE=1 SV=3 P19971|TYPH_HUMAN Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2 Q9Y305|ACOT9_HUMAN Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens GN=ACOT9 PE=1 SV=2 P60866|RS20_HUMAN 40S ribosomal protein S20 OS=Homo sapiens GN=RPS20 PE=1 SV=1 Q9BYJ4|TRI34_HUMAN Tripartite motif-containing protein 34 OS=Homo sapiens GN=TRIM34 PE=1 SV=2 Q8NI51|CTCFL_HUMAN Transcriptional repressor CTCFL OS=Homo sapiens GN=CTCFL PE=1 SV=1 O75083|WDR1_HUMAN WD repeat-containing protein 1 OS=Homo sapiens GN=WDR1 PE=1 SV=4 Q8TES7|FBF1_HUMAN Fas-binding factor 1 OS=Homo sapiens GN=FBF1 PE=1 SV=2 Q01130|SFRS2_HUMAN Splicing factor, arginine/serine-rich 2 OS=Homo sapiens GN=SFRS2 PE=1 SV=4 P36543|VATE1_HUMAN V-type proton ATPase subunit E 1 OS=Homo sapiens GN=ATP6V1E1 PE=1 SV=1 Q9HBG4|VPP4_HUMAN V-type proton ATPase 116 kDa subunit a isoform 4 OS=Homo sapiens GN=ATP6V0A4 PE=1 SV=1 Q9NQW7|XPP1_HUMAN Xaa-Pro aminopeptidase 1 OS=Homo sapiens GN=XPNPEP1 PE=1 SV=3 P62899|RL31_HUMAN 60S ribosomal protein L31 OS=Homo sapiens GN=RPL31 PE=1 SV=1 P62906|RL10A_HUMAN 60S ribosomal protein L10a OS=Homo sapiens GN=RPL10A PE=1 SV=2 P01023|A2MG_HUMAN Alpha-2-macroglobulin OS=Homo sapiens GN=A2M PE=1 SV=2 P0C869|PA24B_HUMAN Cytosolic phospholipase A2 beta OS=Homo sapiens GN=PLA2G4B PE=1 SV=1 O75608|LYPA1_HUMAN Acyl-protein thioesterase 1 OS=Homo sapiens GN=LYPLA1 PE=1 SV=1 Q96TA1|NIBL1_HUMAN Niban-like protein 1 OS=Homo sapiens GN=FAM129B PE=1 SV=2 P49913|CAMP_HUMAN Cathelicidin antimicrobial peptide OS=Homo sapiens GN=CAMP PE=1 SV=1 P42226|STAT6_HUMAN Signal transducer and activator of transcription 6 OS=Homo sapiens GN=STAT6 PE=1 SV=1 P61160|ARP2_HUMAN Actin-related protein 2 OS=Homo sapiens GN=ACTR2 PE=1 SV=1 Q99436|PSB7_HUMAN Proteasome subunit beta type-7 OS=Homo sapiens GN=PSMB7 PE=1 SV=1 Q0VF96|CGNL1_HUMAN Cingulin-like protein 1 OS=Homo sapiens GN=CGNL1 PE=1 SV=1 P13798|ACPH_HUMAN Acylamino-acid-releasing enzyme OS=Homo sapiens GN=APEH PE=1 SV=4 Q9HB71|CYBP_HUMAN Calcyclin-binding protein OS=Homo sapiens GN=CACYBP PE=1 SV=2 Q92616|GCN1L_HUMAN Translational activator GCN1 OS=Homo sapiens GN=GCN1L1 PE=1 SV=5 Q15404|RSU1_HUMAN Ras suppressor protein 1 OS=Homo sapiens GN=RSU1 PE=1 SV=3 Q99798|ACON_HUMAN Aconitate hydratase, mitochondrial OS=Homo sapiens GN=ACO2 PE=1 SV=2 P30046|DOPD_HUMAN D-dopachrome decarboxylase OS=Homo sapiens GN=DDT PE=1 SV=3 Q5TZA2|CROCC_HUMAN Rootletin OS=Homo sapiens GN=CROCC PE=1 SV=1 P12004|PCNA_HUMAN Proliferating cell nuclear antigen OS=Homo sapiens GN=PCNA PE=1 SV=1 P61970|NTF2_HUMAN Nuclear transport factor 2 OS=Homo sapiens GN=NUTF2 PE=1 SV=1 Q8N335|GPD1L_HUMAN Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens GN=GPD1L PE=1 SV=1 P14324|FPPS_HUMAN Farnesyl pyrophosphate synthetase OS=Homo sapiens GN=FDPS PE=1 SV=4 Q9Y5K8|VATD_HUMAN V-type proton ATPase subunit D OS=Homo sapiens GN=ATP6V1D PE=1 SV=1 Q08211|DHX9_HUMAN ATP-dependent RNA helicase A OS=Homo sapiens GN=DHX9 PE=1 SV=4 P59665|DEF1_HUMAN Neutrophil defensin 1 OS=Homo sapiens GN=DEFA1 PE=1 SV=1 P30153|2AAA_HUMAN Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sa P18583|SON_HUMAN Protein SON OS=Homo sapiens GN=SON PE=1 SV=3 Q8NFY4|SEM6D_HUMAN Semaphorin-6D OS=Homo sapiens GN=SEMA6D PE=1 SV=1 Q5VWK0|NBPF6_HUMAN Neuroblastoma breakpoint family member 6 OS=Homo sapiens GN=NBPF6 PE=2 SV=2 P62851|RS25_HUMAN 40S ribosomal protein S25 OS=Homo sapiens GN=RPS25 PE=1 SV=1 Q99536|VAT1_HUMAN Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens GN=VAT1 PE=1 SV=2 Q9BUL8|PDC10_HUMAN Programmed cell death protein 10 OS=Homo sapiens GN=PDCD10 PE=1 SV=1 Q01968|OCRL_HUMAN Inositol polyphosphate 5-phosphatase OCRL-1 OS=Homo sapiens GN=OCRL PE=1 SV=3 Q7Z494|NPHP3_HUMAN Nephrocystin-3 OS=Homo sapiens GN=NPHP3 PE=1 SV=1 P14174|MIF_HUMAN Macrophage migration inhibitory factor OS=Homo sapiens GN=MIF PE=1 SV=4 Q9Y5W7|SNX14_HUMAN Sorting nexin-14 OS=Homo sapiens GN=SNX14 PE=1 SV=3 P14314|GLU2B_HUMAN Glucosidase 2 subunit beta OS=Homo sapiens GN=PRKCSH PE=1 SV=2 Q9NUQ3|TXLNG_HUMAN Gamma-taxilin OS=Homo sapiens GN=TXLNG PE=1 SV=2 Q71UM5|RS27L_HUMAN 40S ribosomal protein S27-like protein OS=Homo sapiens GN=RPS27L PE=1 SV=3 Q6ZR08|DYH12_HUMAN Dynein heavy chain 12, axonemal OS=Homo sapiens GN=DNAH12 PE=2 SV=2 P01903|2DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens GN=HLA-DRA PE=1 SV=1 P51553|IDH3G_HUMAN Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens GN=IDH3G PE=1 SV P10451|OSTP_HUMAN Osteopontin OS=Homo sapiens GN=SPP1 PE=1 SV=1 Q08752|PPID_HUMAN 40 kDa peptidyl-prolyl cis-trans isomerase OS=Homo sapiens GN=PPID PE=1 SV=3 Q14974|IMB1_HUMAN Importin subunit beta-1 OS=Homo sapiens GN=KPNB1 PE=1 SV=2 Q9BTC0|DIDO1_HUMAN Death-inducer obliterator 1 OS=Homo sapiens GN=DIDO1 PE=1 SV=5 Q8N7S2|DNJ5G_HUMAN DnaJ homolog subfamily C member 5G OS=Homo sapiens GN=DNAJC5G PE=1 SV=1 P49720|PSB3_HUMAN Proteasome subunit beta type-3 OS=Homo sapiens GN=PSMB3 PE=1 SV=2 Q9NY33|DPP3_HUMAN Dipeptidyl-peptidase 3 OS=Homo sapiens GN=DPP3 PE=1 SV=2 Q9C099|LRCC1_HUMAN Leucine-rich repeat and coiled-coil domain-containing protein 1 OS=Homo sapiens GN=LRRCC1 PE Q7KZF4|SND1_HUMAN Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens GN=SND1 PE=1 SV=1 Q9ULM0|PKHH1_HUMAN Pleckstrin homology domain-containing family H member 1 OS=Homo sapiens GN=PLEKHH1 PE=2 SV=2 P06744|G6PI_HUMAN Glucose-6-phosphate isomerase OS=Homo sapiens GN=GPI PE=1 SV=4 P27482|CALL3_HUMAN Calmodulin-like protein 3 OS=Homo sapiens GN=CALML3 PE=1 SV=2 Q01813|K6PP_HUMAN 6-phosphofructokinase type C OS=Homo sapiens GN=PFKP PE=1 SV=2 P55060|XPO2_HUMAN Exportin-2 OS=Homo sapiens GN=CSE1L PE=1 SV=3 Q5H9F3|BCORL_HUMAN BCoR-like protein 1 OS=Homo sapiens GN=BCORL1 PE=1 SV=1 Q92882|OSTF1_HUMAN Osteoclast-stimulating factor 1 OS=Homo sapiens GN=OSTF1 PE=1 SV=2 P07858|CATB_HUMAN Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3 P02788|TRFL_HUMAN Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 O60296|TRAK2_HUMAN Trafficking kinesin-binding protein 2 OS=Homo sapiens GN=TRAK2 PE=1 SV=2 Q8NCA9|ZN784_HUMAN Zinc finger protein 784 OS=Homo sapiens GN=ZNF784 PE=2 SV=1 Q92889|XPF_HUMAN DNA repair endonuclease XPF OS=Homo sapiens GN=ERCC4 PE=1 SV=3

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Significance threshold p< 0.05 Max. number of hits AUTO Standard scoring %$#"! MudPIT scoring %$#"! Ions score or expect cut-off 0 Show sub-sets 0 Show pop-ups %$#"! Suppress pop-ups %$#"! Sort unassigned Decreasing Score Require bold red 

1. P35908|K22E_HUMAN Mass: 65678 Score: 8377 Queries matched: 396 emPAI: 5.86 Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens GN=KRT2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 7 8084 416.2434 830.4722 830.4862 -0.0140 0 61 5.4e-005 1 R.SLVGLGGTK.S 8060 900 8071 8074 908 8078 8079 8080 8081 8082 15224 487.2647 972.5147 972.5240 -0.0092 0 62 4e-005 1 K.IEISELNR.V 15200 15203 15205 15206 15208 15209 15212 15213 15799 497.7749 993.5353 993.5607 -0.0254 0 57 0.00011 1 R.LQGEIAHVK.K 15798 15800 15801 15802 15803 15804 15805 1580 15843 498.7620 995.5095 995.5148 -0.0053 1 34 0.021 1 R.GEHALKDAR.N 16103 503.2325 1004.4505 1004.4597 -0.0092 0 55 0.0002 1 K.LLEGEECR.M 16092 16093 16094 16095 16096 16097 16098 16099 16680 513.7732 1025.5319 1025.5505 -0.0186 1 44 0.002 1 R.HGDSLKEIK.I 17016 519.2558 1036.4970 1036.5189 -0.0219 0 65 1.5e-005 1 R.YLDGLTAER.T 17010 17011 17012 17013 17014 17015 5445 5447 1 17040 519.7538 1037.4930 1037.5029 -0.0099 1 23 0.28 1 K.KYEDEINK.R 17121 521.2870 1040.5594 1040.5502 0.0092 0 54 0.00021 1 K.VDPEIQNVK.A 17082 17089 17096 18105 533.7516 1065.4887 1065.5090 -0.0204 1 43 0.0025 1 K.YEDEINKR.T 18099 18100 18101 18104 18106 18107 18108 18109 18138 534.7474 1067.4803 1067.4957 -0.0155 0 (42) 0.0035 1 K.DVDNAYMIK.V 18137 18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 18638 542.7429 1083.4712 1083.4906 -0.0194 0 55 0.00015 1 K.DVDNAYMIK.V 18636 5928 19391 554.2758 1106.5370 1106.5356 0.0014 0 60 5.4e-005 1 K.AQYEEIAQR.S 19361 19362 19363 19366 19367 19368 19370 19373 19804 561.8164 1121.6181 1121.6557 -0.0375 1 10 5.8 1 R.LQGEIAHVKK.Q 20046 566.2517 1130.4889 1130.5026 -0.0137 0 58 9.1e-005 1 R.STSSFSCLSR.H 20034 20035 20036 20037 20038 20039 20040 2004 20118 567.2733 1132.5321 1132.5546 -0.0226 1 46 0.0013 1 R.KLLEGEECR.M 20111 20113 20114 20115 20121 20122 20124 2012 6329 570.2649 1138.5152 1138.5328 -0.0176 0 (19) 1.4 2 R.DYQELMNVK.L 20312 20693 578.2618 1154.5091 1154.5278 -0.0186 0 46 0.0012 1 R.DYQELMNVK.L 20690 20692 20694 21404 597.2956 1192.5767 1192.6088 -0.0321 0 72 3e-006 1 K.YEELQVTVGR.H 21400 21403 21405 21406 21407 21408 21608 599.2805 1196.5464 1196.5422 0.0042 0 59 5.4e-005 1 K.GGSISGGGYGSGGGK.H 21590 21591 21596 6602 21597 21598 6603 2 21922 604.7995 1207.5844 1207.6085 -0.0241 0 90 4.9e-008 1 R.TAAENDFVTLK.K 21916 21917 21918 21919 21920 21921 21923 21 22040 606.7916 1211.5687 1211.5856 -0.0169 1 21 0.33 1 K.KDVDNAYMIK.V 22039 23005 627.8002 1253.5858 1253.6001 -0.0142 0 107 9.6e-010 1 R.GFSSGSAVVSGGSR.R 22984 22985 22986 22988 22991 22992 22993 23710 429.8692 1286.5857 1286.6037 -0.0181 1 43 0.0024 1 R.RSTSSFSCLSR.H 23707 24495 440.8550 1319.5433 1319.5756 -0.0323 0 47 0.00097 1 R.HGGGGGGFGGGGFGSR.S 24496 24497 24498 24500 24501 24507 245 24669 665.3084 1328.6022 1328.6320 -0.0299 0 85 1.7e-007 1 K.NVQDAIADAEQR.G 24666 24667 24668 24670 24672 24678 665.3538 1328.6930 1328.7187 -0.0257 0 59 6.9e-005 1 R.NLDLDSIIAEVK.A 24677 24761 446.2403 1335.6991 1335.7034 -0.0043 1 46 0.0011 1 R.TAAENDFVTLKK.D 24731 24737 24741 24742 24743 24744 24745 24 25500 686.3441 1370.6735 1370.7041 -0.0306 0 100 4.2e-009 1 K.LNDLEEALQQAK.E 25499 25722 464.5554 1390.6444 1390.6728 -0.0284 1 52 0.00027 1 R.SKEEAEALYHSK.Y 25721 25724 25725 25726 25727 25728 25729 25 25947 470.8961 1409.6663 1409.7012 -0.0348 1 23 0.18 1 R.GFSSGSAVVSGGSRR.S 25946 25950 25953 25956 26377 730.8770 1459.7394 1459.7922 -0.0528 0 92 3e-008 1 K.VDLLNQEIEFLK.V 26376 26478 738.3798 1474.7451 1474.7780 -0.0329 0 112 2.7e-010 1 R.FLEQQNQVLQTK.W 26455 26462 26464 26466 26468 26469 26470 2 27614 870.8376 1739.6606 1739.6983 -0.0377 0 151 1.5e-014 1 R.GSSSGGGYSSGSSSYGSGGR.Q 27609 27610 27611 27612 27613 27615 27622 871.3550 1740.6953 1740.7412 -0.0459 0 83 1.1e-007 1 R.GGSGGGGSISGGGYGSGGGSGGR.Y 28801 758.0029 2270.9870 2271.0325 -0.0455 1 37 0.0044 1 R.TSQNSELNNM QDLVEDYKK.K

2. P13645|K1C10_HUMAN Mass: 59020 Score: 7862 Queries matched: 439 emPAI: 3.61 Keratin, type I cytoskeletal 10 OS=Homo sapiens GN=KRT10 PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7182 404.1948 806.3751 806.3923 -0.0171 0 50 0.00056 1 R.LAADDFR.L 7180 7181 7183 7184 7185 7186 7187 7188 7189 7190 7281 405.2146 808.4146 808.4330 -0.0184 0 48 0.00092 1 R.LASYLDK.V 230 7269 7273 7275 7276 7277 7278 7279 7282 7283 7 9656 424.2228 846.4310 846.4447 -0.0137 0 49 0.00077 1 K.SEITELR.R 9653 9654 1432 9655 9658 9659 9660 9661 9662 9663 15069 483.7219 965.4293 965.4494 -0.0201 1 8 8.2 1 R.DYSKYYK.T 15774 497.2461 992.4776 992.4927 -0.0151 0 59 6.5e-005 1 K.YENEVALR.Q 15762 15763 4962 15765 15766 15767 15768 15769 1 15824 498.2551 994.4956 994.5123 -0.0167 1 42 0.0035 1 K.IKEWYEK.H 15815 15816 15818 15819 15820 15821 15822 15823 1 16036 502.2670 1002.5194 1002.5458 -0.0263 1 21 0.43 1 K.SEITELRR.N 16028 16030 16032 16033 16035 16037 16038 16041 16814 516.2873 1030.5601 1030.5910 -0.0309 0 58 9e-005 1 R.VLDELTLTK.A 16811 16812 16813 5345 5347 5348 5350 16815 535 17989 532.7985 1063.5825 1063.6026 -0.0200 1 59 6.9e-005 1 R.LASYLDKVR.A 17977 5769 17983 17984 17985 17986 17987 17988 18871 545.7505 1089.4864 1089.5237 -0.0373 0 (52) 0.00035 1 K.VTMQNLNDR.L 18872 18873 18875 19284 553.7642 1105.5138 1105.5186 -0.0048 0 65 2e-005 1 K.VTMQNLNDR.L 19265 19266 19267 19268 19270 19272 19273 19274 19466 555.2533 1108.4920 1108.4825 0.0095 0 67 9.1e-006 1 K.DAEAWFNEK.S 19439 19440 19441 19443 19444 19445 19446 19447 20910 583.2761 1164.5377 1164.5775 -0.0398 0 71 4.1e-006 1 R.LENEIQTYR.S 20909 20912 20913 20915 20918 20919 20926 20927 21733 601.3014 1200.5882 1200.6098 -0.0216 0 64 1.9e-005 1 R.QSVEADINGLR.R 21729 21730 21731 21732 21734 22585 617.8317 1233.6489 1233.6717 -0.0228 1 65 1.6e-005 1 R.LKYENEVALR.Q 22572 22574 22575 22579 22580 22581 22582 2258 22686 413.1995 1236.5767 1236.5775 -0.0007 1 29 0.058 1 R.KDAEAWFNEK.S 22687 23162 631.7915 1261.5684 1261.5899 -0.0215 0 100 4.5e-009 1 R.SLLEGEGSSGGGGR.G 23150 23152 23153 23154 23155 23156 23158 24040 434.1994 1299.5763 1299.5877 -0.0114 1 (18) 0.68 1 K.NHEEEMKDLR.N 24039 24437 439.5301 1315.5685 1315.5826 -0.0141 1 34 0.017 1 K.NHEEEMKDLR.N 24432 24433 2682 24434 24435 24436 24438 2443 25213 453.2353 1356.6841 1356.7110 -0.0269 1 42 0.0029 1 R.QSVEADINGLRR.V 25211 25212 25214 25215 25389 683.3120 1364.6095 1364.6320 -0.0225 0 91 3.6e-008 1 R.SQYEQLAEQNR.K 25378 25379 25380 25381 25382 25383 25384 253 25590 691.3120 1380.6095 1380.6408 -0.0314 0 115 1.5e-010 1 R.ALEESNYELEGK.I 25578 25579 25580 25581 25582 25583 25584 25 25707 695.8190 1389.6234 1389.6736 -0.0501 0 88 6.8e-008 1 K.QSLEASLAETEGR.Y 25708 25710 25712 25713 26193 478.9197 1433.7373 1433.7626 -0.0253 1 21 0.32 1 K.IRLENEIQTYR.S 26194 26616 498.5676 1492.6809 1492.7270 -0.0461 1 43 0.0023 1 R.SQYEQLAEQNRK.D 26617 26618 26620 26621 26622 26623 26624 2 26929 775.3205 1548.6264 1548.6700 -0.0436 0 138 5.3e-013 1 R.SGGGGGGGGCGGGGGVSSLR.I 27504 854.3827 1706.7508 1706.7649 -0.0141 0 112 2.1e-010 1 K.GSLGGGFSSGGFSGGSFSR.G 27499 27500 27501 27502 27503 28445 694.9706 2081.8898 2081.9575 -0.0677 0 65 7.8e-006 1 R.AETECQNTEYQQLLDIK.I

3. P04264|K2C1_HUMAN Mass: 66170 Score: 7376 Queries matched: 424 emPAI: 4.44 Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8128 416.7437 831.4729 831.4814 -0.0085 0 40 0.0073 1 K.SISISVAR.G 922 8106 8107 8108 8109 8110 8111 8112 8113 8114 11739 437.7547 873.4947 873.4920 0.0028 0 56 0.0002 1 R.SLVNLGGSK.S 11676 11677 11678 11679 11681 11682 11683 11687 12458 448.2325 894.4504 894.4519 -0.0015 1 1 39 3 R.RTTSSSTR.R 14061 466.7459 931.4771 931.4974 -0.0203 1 34 0.024 1 R.SEIDNVKK.Q 3902 14066 14070 15224 487.2647 972.5147 972.5240 -0.0092 0 62 4e-005 1 K.IEISELNR.V 15200 15203 15205 15206 15208 15209 15212 15213

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15877 500.2164 998.4182 998.4379 -0.0197 0 35 0.016 1 K.DVDGAYMTK.V 15876 15878 16298 508.2162 1014.4179 1014.4328 -0.0149 0 (23) 0.3 1 K.DVDGAYMTK.V 16293 16296 16297 16299 16300 16301 16307 16903 517.2573 1032.5000 1032.5087 -0.0087 0 61 4.6e-005 1 R.TLLEGEESR.M 16871 16875 16876 16877 16878 16879 5380 16881 18014 533.2506 1064.4867 1064.5138 -0.0271 0 60 4.9e-005 1 K.AQYEDIAQK.S 18006 18009 18011 18013 18017 18018 18020 18021 18105 533.7516 1065.4887 1065.5090 -0.0204 1 43 0.0025 1 K.YEDEINKR.T 18099 18100 18101 18104 18106 18107 18108 18109 18317 537.2909 1072.5672 1072.5876 -0.0205 1 42 0.0042 1 R.LRSEIDNVK.K 18299 18309 18315 18319 19940 563.2795 1124.5443 1124.5349 0.0094 0 79 6.1e-007 1 K.AEAESLYQSK.Y 19906 19907 19908 19912 19914 19915 19916 1991 20343 571.2493 1140.4841 1140.5121 -0.0280 0 (33) 0.025 1 R.DYQELMNTK.L 20344 20651 576.7691 1151.5236 1151.5458 -0.0223 1 38 0.0087 1 R.NKYEDEINK.R 20648 20719 579.2498 1156.4851 1156.5070 -0.0219 0 48 0.00076 1 R.DYQELMNTK.L 20714 20715 20716 20717 20718 20720 20721 20723 21061 588.2799 1174.5453 1174.5942 -0.0489 1 16 1.4 3 R.VDQLKSDQSR.L 21190 590.2897 1178.5649 1178.5931 -0.0282 0 96 1.4e-008 1 K.YEELQITAGR.H 21184 21186 21187 21188 21189 21192 21193 211 23276 633.3047 1264.5948 1264.6299 -0.0351 0 93 2.1e-008 1 R.TNAENEFVTIK.K 23277 23278 23279 23280 23281 23282 23283 232 23504 426.5440 1276.6101 1276.6259 -0.0158 1 22 0.33 1 K.SDQSRLDSELK.N 23503 24148 651.8415 1301.6684 1301.7078 -0.0394 0 80 4.4e-007 1 R.SLDLDSIIAEVK.A 24149 24150 24694 666.7477 1331.4808 1331.5122 -0.0314 0 39 0.0034 1 K.NMQDMVEDYR.N 24693 24870 670.8361 1339.6577 1339.6619 -0.0042 1 78 7.6e-007 1 K.SKAEAESLYQSK.Y 24838 24840 24841 24842 24843 24844 24845 24 25208 679.3359 1356.6573 1356.6885 -0.0312 0 97 1.1e-008 1 K.LNDLEDALQQAK.E 25203 25204 25206 25207 25635 692.3253 1382.6361 1382.6830 -0.0469 0 61 4e-005 1 K.SLNNQFASFIDK.V 6923 25636 6924 6926 6927 25767 465.2365 1392.6876 1392.7249 -0.0372 1 69 5.5e-006 1 R.TNAENEFVTIKK.D 25760 25762 25763 25764 25766 25768 25769 25 26461 738.3646 1474.7147 1474.7416 -0.0269 0 76 1e-006 1 K.WELLQQVDTSTR.T 26453 26455 26478 738.3798 1474.7451 1474.7780 -0.0329 0 112 2.7e-010 1 R.FLEQQNQVLQTK.W 26462 26464 26466 26468 26469 26470 26471 2 27374 829.3983 1656.7820 1656.7856 -0.0036 0 103 1.7e-009 1 R.SGGGFSSGSAGIINYQR.R 27531 572.9443 1715.8110 1715.8438 -0.0328 0 34 0.013 1 K.QISNLQQSISDAEQR.G 27530 27634 584.6043 1750.7911 1750.8195 -0.0284 1 40 0.0034 1 R.GSGGGSSGGSIGGRGSSSGGVK.S 27636 27637 27639 27640 27641 28435 693.9633 2078.8682 2078.9075 -0.0393 1 30 0.021 1 R.GGSGGGGGGSSGGRGSGGGSSGGSIGGR.G 28436 28936 795.3239 2382.9500 2382.9447 0.0053 0 42 0.0006 1 R.GGGGGGYGSGGSSYGSGGGSYGSGGGGGGGR.G 28935

4. P35527|K1C9_HUMAN Mass: 62255 Score: 6024 Queries matched: 257 emPAI: 1.68 Keratin, type I cytoskeletal 9 OS=Homo sapiens GN=KRT9 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5733 531.2882 530.2810 530.3064 -0.0254 0 9 29 1 K.AALEK.S 7281 405.2146 808.4146 808.4330 -0.0184 0 48 0.00092 1 R.LASYLDK.V 230 7269 7273 7275 7276 7277 7278 7279 7282 7283 7 12494 449.2042 896.3939 896.4062 -0.0123 0 (32) 0.031 1 R.MTLDDFR.I 12491 12492 12493 3154 3155 3196 13318 457.1936 912.3726 912.4011 -0.0285 0 42 0.0028 1 R.MTLDDFR.I 13319 3586 13320 13321 13322 13323 3588 13324 133 15089 484.2197 966.4248 966.4447 -0.0198 0 28 0.083 1 K.IQDWYDK.K 15088 15090 4576 17815 530.7804 1059.5463 1059.5560 -0.0097 0 61 4.7e-005 1 K.TLLDIDNTR.M 17785 17790 17791 17792 17796 17799 17800 17801 18001 533.2387 1064.4629 1064.4920 -0.0291 0 58 9e-005 1 K.STMQELNSR.L 18007 18008 18019 18023 18038 18098 533.7409 1065.4673 1065.4913 -0.0240 0 (28) 0.075 1 K.FEMEQNLR.Q 18099 18100 18101 18104 18105 18107 18109 18113 18339 537.7402 1073.4659 1073.5142 -0.0483 0 5 20 3 R.QFSSSYLSR.S 18592 541.2465 1080.4785 1080.4870 -0.0084 0 (50) 0.00047 1 K.STMQELNSR.L 18590 18594 18613 541.7344 1081.4543 1081.4862 -0.0319 0 32 0.029 1 K.FEMEQNLR.Q 18615 18617 18619 19050 548.2639 1094.5132 1094.5396 -0.0264 1 21 0.41 1 K.IQDWYDKK.G 19048 19754 561.2900 1120.5655 1120.5764 -0.0109 0 42 0.0033 1 R.QEYEQLIAK.N 19725 19727 19728 19731 19736 19738 19740 1974 20686 577.7810 1153.5474 1153.5801 -0.0327 1 4 19 10 R.MTLDDFRIK.F 20738 579.2905 1156.5665 1156.5836 -0.0171 0 96 1.4e-008 1 R.QGVDADINGLR.Q 20712 20725 20726 20728 20732 20734 20735 207 21864 603.7909 1205.5673 1205.5962 -0.0289 0 59 6.3e-005 1 R.QVLDNLTMEK.S 21848 21861 21862 21865 21866 21867 21868 22512 616.8026 1231.5907 1231.5906 0.0002 0 116 1.2e-010 1 R.SGGGGGGGLGSGGSIR.S 22478 22479 22480 22481 22482 22483 224 22624 618.2616 1234.5086 1234.5215 -0.0129 0 93 2.3e-008 1 R.FSSSSGYGGGSSR.V 22607 22608 22609 22610 22611 22612 22613 2 24418 658.3162 1314.6179 1314.6779 -0.0600 0 13 2.6 1 K.DQIVDLTVGNNK.T 24559 441.8890 1322.6453 1322.6652 -0.0199 1 42 0.003 1 R.IKFEMEQNLR.Q 24545 24554 24556 24557 24558 24560 24561 245 25065 450.9036 1349.6891 1349.6800 0.0090 1 18 0.73 1 K.IGLGGRGGSGGSYGR.G 25054 25055 25056 25057 25059 25060 2506 27060 793.8595 1585.7045 1585.7583 -0.0539 0 104 1.8e-009 1 K.VQALEEANNDLENK.I 27061 27064 27740 896.3452 1790.6758 1790.7205 -0.0447 0 124 6.6e-012 1 R.GGSGGSYGGGGSGGGYGGGSGSR.G 27736 27737 27738 27739 27741 27

5. P02533|K1C14_HUMAN Mass: 51872 Score: 4158 Queries matched: 230 emPAI: 1.84 Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7182 404.1948 806.3751 806.3923 -0.0171 0 50 0.00056 1 R.LAADDFR.T 7180 7181 7183 7184 7185 7186 7187 7188 7189 7190 7281 405.2146 808.4146 808.4330 -0.0184 0 48 0.00092 1 R.LASYLDK.V 230 7269 7273 7275 7276 7277 7278 7279 7282 7283 7 8146 417.2127 832.4109 832.4290 -0.0181 0 19 0.81 1 K.SEISELR.R 8144 8145 13599 460.2057 918.3968 918.4123 -0.0155 0 14 2.7 1 K.DYSPYFK.T 15635 494.7690 987.5235 987.5349 -0.0114 1 8 11 6 K.TIEDLRNK.I 15626 15666 495.2607 988.5068 988.5301 -0.0233 1 24 0.25 1 K.SEISELRR.T 15661 15667 15672 15673 15675 15678 15685 16769 515.2890 1028.5634 1028.5866 -0.0231 0 49 0.0007 1 R.VLDELTLAR.A 5322 16770 16771 5324 5326 16773 16774 16775 16 17989 532.7985 1063.5825 1063.6026 -0.0200 1 59 6.9e-005 1 R.LASYLDKVR.A 17977 5769 17983 17984 17985 17986 17987 17988 18871 545.7505 1089.4864 1089.5237 -0.0373 0 (52) 0.00035 1 K.VTMQNLNDR.L 18872 18873 18875 19284 553.7642 1105.5138 1105.5186 -0.0048 0 65 2e-005 1 K.VTMQNLNDR.L 19265 19266 19267 19268 19270 19272 19273 19274 19304 553.7890 1105.5634 1105.5550 0.0084 0 66 1.6e-005 1 R.ISSVLAGGSCR.A 19288 19291 19294 19296 19297 19298 19302 193 19798 561.7848 1121.5550 1121.5717 -0.0166 0 53 0.00026 1 R.LEQEIATYR.R 19797 21032 586.7595 1171.5044 1171.5186 -0.0142 0 51 0.0004 1 K.DAEEWFFTK.T 21306 593.2736 1184.5327 1184.6877 -0.1550 1 6 14 7 R.RVLDELTLAR.A 22245 610.7915 1219.5684 1219.5932 -0.0248 0 90 5.6e-008 1 K.ASLENSLEETK.G 22244 23522 639.7946 1277.5747 1277.5783 -0.0036 0 75 1.6e-006 1 K.GSCGIGGGIGGGSSR.I 23513 23514 23515 23516 23517 23518 2351 24050 651.3169 1300.6193 1300.6510 -0.0317 0 85 1.3e-007 1 R.ALEEANADLEVK.I 24045 24046 24047 24051 24052 24053 24055 24 25336 681.3382 1360.6618 1360.6834 -0.0216 0 110 4.7e-010 1 R.EVATNSELVQSGK.S 25326 25327 25328 25329 25331 25334 25335 2 26101 713.3346 1424.6546 1424.6896 -0.0350 0 78 6.8e-007 1 R.APSTYGGGLSVSSSR.F 26093 26094 26095 26096 26097 26098 2609 26176 478.5668 1432.6785 1432.7157 -0.0373 1 43 0.0021 1 K.ASLENSLEETKGR.Y

6. P08670|VIME_HUMAN Mass: 53676 Score: 3551 Queries matched: 262 emPAI: 3.68 Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10977 435.7139 869.4132 869.4283 -0.0151 0 32 0.03 1 R.FANYIDK.V 10976 10978 10979 10981 10982 10985 10986 10987 1 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.I 13068 13069 13070 13071 13072 13073 13075 13076 1 13393 457.7253 913.4361 913.4505 -0.0144 0 14 2.1 1 R.SYVTTSTR.T 14047 466.7354 931.4562 931.4610 -0.0048 0 57 0.00012 1 K.LLEGEESR.I 14026 14029 14031 14032 14033 14034 14035 14036 16565 512.2579 1022.5012 1022.5033 -0.0020 0 51 0.00047 1 R.QQYESVAAK.N 16550 16554 16557 16560 16561 16562 16563 5286

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17401 523.7607 1045.5068 1045.5226 -0.0158 0 45 0.0019 1 K.LQEEMLQR.E 17769 530.7558 1059.4971 1059.5197 -0.0226 0 60 7.2e-005 1 R.QVDQLTNDK.A 17767 17771 17772 17774 17776 17777 17778 1777 17829 530.7865 1059.5584 1059.5560 0.0024 1 58 0.00011 1 R.KLLEGEESR.I 17770 17794 17795 17797 17798 17803 17805 1780 17894 531.7533 1061.4920 1061.5175 -0.0255 0 (11) 5.1 1 K.LQEEMLQR.E 17896 18429 538.7457 1075.4768 1075.4968 -0.0200 0 47 0.0011 1 R.DNLAEDIMR.L 18430 18431 18432 18434 18435 18750 544.7659 1087.5173 1087.5258 -0.0084 0 84 2.3e-007 1 R.QDVDNASLAR.L 18737 18738 18740 18741 18742 18744 18745 1874 18909 546.7497 1091.4848 1091.4917 -0.0069 0 (36) 0.014 1 R.DNLAEDIMR.L 18906 18907 18908 18910 18911 18998 547.2657 1092.5168 1092.5200 -0.0032 0 80 5.1e-007 1 K.FADLSEAANR.N 18955 18957 18960 18962 18968 18969 18970 1897 19582 558.2762 1114.5378 1114.5618 -0.0241 0 58 7.6e-005 1 K.VELQELNDR.F 19578 19581 19583 19584 19585 19587 19588 1958 19757 561.2916 1120.5687 1120.5764 -0.0077 0 59 6.5e-005 1 R.EYQDLLNVK.M 19721 19722 19732 19735 19737 19741 19742 19743 19947 563.2982 1124.5818 1124.5978 -0.0160 1 46 0.0012 1 R.FANYIDKVR.F 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.I 22184 608.7982 1215.5819 1215.6208 -0.0389 1 42 0.0032 1 R.RQVDQLTNDK.A 22185 22982 627.7785 1253.5424 1253.5598 -0.0174 0 67 9.6e-006 1 R.LGDLYEEEMR.E 22983 23419 635.7718 1269.5291 1269.5547 -0.0256 0 (60) 4.3e-005 1 R.LGDLYEEEMR.E 23416 23417 23418 23420 23421 23717 429.8944 1286.6613 1286.6579 0.0034 1 19 0.54 1 R.QVDQLTNDKAR.V 23711 23712 23714 24275 655.2977 1308.5808 1308.5986 -0.0178 0 46 0.001 1 K.NLQEAEEWYK.S 24276 24277 24550 662.3092 1322.6037 1322.6102 -0.0065 0 89 5.8e-008 1 R.EEAENTLQSFR.Q 24538 24539 24540 24541 24542 6854 24543 2454 26144 714.8402 1427.6658 1427.7045 -0.0387 0 69 6e-006 1 R.SLYASSPGGVYATR.S 26653 499.2558 1494.7456 1494.7790 -0.0335 0 9 5 1 R.TYSLGSALRPSTSR.S 27069 529.9275 1586.7606 1586.7900 -0.0294 1 52 0.00026 1 R.TNEKVELQELNDR.F 27067 27068 27070 27071 27072 27073 27074 27396 556.9533 1667.8382 1667.8366 0.0015 0 23 0.19 1 R.ETNLDSLPLVDTHSK.R 27395 27484 568.9368 1703.7886 1703.8148 -0.0262 1 30 0.039 1 R.VEVERDNLAEDIMR.L 27483 27814 612.9355 1835.7847 1835.7922 -0.0075 0 12 2.2 1 R.DGQVINETSQHHDDLE.- 27813

7. P08779|K1C16_HUMAN Mass: 51578 Score: 2977 Queries matched: 214 emPAI: 2.05 Keratin, type I cytoskeletal 16 OS=Homo sapiens GN=KRT16 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7182 404.1948 806.3751 806.3923 -0.0171 0 50 0.00056 1 R.LAADDFR.T 7180 7181 7183 7184 7185 7186 7187 7188 7189 7190 7281 405.2146 808.4146 808.4330 -0.0184 0 48 0.00092 1 R.LASYLDK.V 230 7269 7273 7275 7276 7277 7278 7279 7282 7283 7 8146 417.2127 832.4109 832.4290 -0.0181 0 8 9.8 5 R.SEVTELR.R 8144 8145 13599 460.2057 918.3968 918.4123 -0.0155 0 14 2.7 1 K.DYSPYFK.T 15635 494.7690 987.5235 987.5349 -0.0114 1 8 11 6 K.TIEDLRNK.I 15626 15666 495.2607 988.5068 988.5301 -0.0233 1 18 1 3 R.SEVTELRR.V 15656 15661 15665 15672 15673 15678 15685 16769 515.2890 1028.5634 1028.5866 -0.0231 0 49 0.0007 1 R.VLDELTLAR.T 5322 16770 16771 5324 5326 16773 16774 16775 16 17989 532.7985 1063.5825 1063.6026 -0.0200 1 59 6.9e-005 1 R.LASYLDKVR.A 17977 5769 17983 17984 17985 17986 17987 17988 18871 545.7505 1089.4864 1089.5237 -0.0373 0 (52) 0.00035 1 K.VTMQNLNDR.L 18872 18873 18875 19073 548.7600 1095.5053 1095.5237 -0.0183 0 14 1.9 1 R.DAETWFLSK.T 19284 553.7642 1105.5138 1105.5186 -0.0048 0 65 2e-005 1 K.VTMQNLNDR.L 19265 19266 19267 19268 19270 19272 19273 19274 19304 553.7890 1105.5634 1105.5550 0.0084 0 66 1.6e-005 1 R.ISSVLAGGSCR.A 19288 19291 19294 19296 19297 19298 19302 193 19798 561.7848 1121.5550 1121.5717 -0.0166 0 53 0.00026 1 R.LEQEIATYR.R 19797 21306 593.2736 1184.5327 1184.6877 -0.1550 1 6 14 7 R.RVLDELTLAR.T 22245 610.7915 1219.5684 1219.5932 -0.0248 0 90 5.6e-008 1 K.ASLENSLEETK.G 22244 23101 420.5551 1258.6436 1258.6669 -0.0234 1 30 0.047 1 R.TKYEHELALR.Q 23100 23115 630.7749 1259.5351 1259.5630 -0.0278 0 50 0.00045 1 R.EVFTSSSSSSSR.Q 23114 23117 23118 23133 23522 639.7946 1277.5747 1277.5783 -0.0036 0 75 1.6e-006 1 K.GSCGIGGGIGGGSSR.I 23513 23514 23515 23516 23517 23518 2351 24050 651.3169 1300.6193 1300.6510 -0.0317 0 85 1.3e-007 1 R.ALEEANADLEVK.I 24045 24046 24047 24051 24052 24053 24055 24 24808 669.8343 1337.6540 1337.6575 -0.0036 0 59 5.3e-005 1 R.APSTYGGGLSVSSR.F 24804 24805 24806 24807 24810 25213 453.2353 1356.6841 1356.7110 -0.0269 1 4 21 6 R.QTVEADVNGLRR.V 25903 703.3341 1404.6537 1404.6845 -0.0307 0 86 9.8e-008 1 K.EVASNSELVQSSR.S 25902 26176 478.5668 1432.6785 1432.7157 -0.0373 1 43 0.0021 1 K.ASLENSLEETKGR.Y

8. P13647|K2C5_HUMAN Mass: 62568 Score: 2723 Queries matched: 262 emPAI: 2.77 Keratin, type II cytoskeletal 5 OS=Homo sapiens GN=KRT5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7315 405.7038 809.3931 809.4032 -0.0100 0 20 0.48 1 R.QSSVSFR.S 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 7 12005 442.7163 883.4181 883.4400 -0.0218 0 38 0.008 1 R.TSFTSVSR.S 12004 12006 12007 12008 12009 12010 12011 12012 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.V 13068 13069 13070 13071 13072 13073 13075 13076 1 14220 469.7402 937.4658 937.4869 -0.0211 0 42 0.0029 1 R.SLYNLGGSK.R 14218 14219 14221 14222 14223 14224 14226 14230 14449 473.2554 944.4962 944.5039 -0.0078 1 44 0.0028 1 R.GRLDSELR.N 14428 14430 14432 14435 14436 14437 14438 14439 16103 503.2325 1004.4505 1004.4597 -0.0092 0 55 0.0002 1 K.LLEGEECR.L 16092 16093 16094 16095 16096 16097 16098 16099 16333 508.7607 1015.5068 1015.5298 -0.0230 0 53 0.0003 1 R.QLDSIVGER.G 16329 16331 16332 16334 16335 16858 516.7535 1031.4924 1031.5247 -0.0323 1 3 32 6 R.TEEREQIK.T 18105 533.7516 1065.4887 1065.5090 -0.0204 1 43 0.0025 1 K.YEDEINKR.T 18099 18100 18101 18104 18106 18107 18108 18109 18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 18966 547.2576 1092.5007 1092.5199 -0.0192 0 58 8e-005 1 K.AQYEEIANR.S 18948 18949 18953 18958 18959 18961 18965 18967 19041 547.7813 1093.5481 1093.5880 -0.0399 1 34 0.018 1 R.SLYNLGGSKR.I 19040 19042 19043 19045 19507 556.2696 1110.5247 1110.5669 -0.0422 0 70 4.7e-006 1 R.ISISTSGGSFR.N 19511 19512 19513 19514 19515 19516 19517 195 20118 567.2733 1132.5321 1132.5546 -0.0226 1 46 0.0013 1 R.KLLEGEECR.L 20111 20113 20114 20115 20121 20122 20124 2012 20423 572.2977 1142.5809 1142.6183 -0.0374 0 66 1.4e-005 1 K.LAELEEALQK.A 20424 20426 20428 20651 576.7691 1151.5236 1151.5458 -0.0223 1 38 0.0087 1 K.NKYEDEINK.R 20648 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.V 21034 586.8087 1171.6028 1171.6309 -0.0281 1 48 0.00079 1 R.RQLDSIVGER.G 21434 597.7839 1193.5532 1193.5676 -0.0145 0 91 3.9e-008 1 K.YEELQQTAGR.H 21421 21422 21423 21424 21425 21426 21427 2142 22800 621.7717 1241.5288 1241.5564 -0.0276 0 48 0.00077 1 R.TEAESWYQTK.Y 22799 23012 627.8039 1253.5932 1253.6113 -0.0181 1 16 1.3 2 R.QSSVSFRSGGSR.S 22984 22985 22986 22988 22992 22993 22995 22 23976 649.8011 1297.5875 1297.6224 -0.0348 0 74 1.7e-006 1 R.TTAENEFVMLK.K 23977 23978 24678 665.3538 1328.6930 1328.7187 -0.0257 0 59 6.9e-005 1 R.NLDLDSIIAEVK.A 24677 25943 705.8211 1409.6277 1409.6722 -0.0444 0 48 0.00068 1 R.VSLAGACGVGGYGSR.S 25945 705.8373 1409.6600 1409.7151 -0.0550 0 76 1.1e-006 1 R.SFSTASAITPSVSR.T 25948 25955 25957 26222 720.3438 1438.6731 1438.7053 -0.0322 0 68 6e-006 1 R.GLGVGFGSGGGSSSSVK.F

9. P60709|ACTB_HUMAN Mass: 42052 Score: 2622 Queries matched: 209 emPAI: 3.27 Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7054 400.7707 799.5268 799.5280 -0.0012 1 26 0.17 1 K.RGILTLK.Y 7044 7045 7047 7048 7049 7050 7051 7052 7053 7055

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12939 453.2286 904.4426 904.4436 -0.0011 1 29 0.084 1 K.CDVDIRK.D 12936 12942 13757 462.2761 922.5376 922.5600 -0.0224 1 31 0.045 1 K.IIAPPERK.Y 13752 13753 13755 13756 13758 13759 13760 13761 15332 488.7144 975.4142 975.4410 -0.0268 0 83 2.8e-007 1 K.AGFAGDDAPR.A 15331 15333 15334 15335 15336 15337 15338 1533 15870 499.7448 997.4751 997.4790 -0.0039 0 (25) 0.16 1 R.DLTDYLMK.I 15866 16278 507.7451 1013.4756 1013.4739 0.0017 0 35 0.02 1 R.DLTDYLMK.I 16269 16270 16271 16272 5233 16274 16275 16276 1 17005 518.8265 1035.6383 1035.6440 -0.0057 1 22 0.38 1 K.IKIIAPPER.K 17006 20073 566.7574 1131.5002 1131.5197 -0.0195 0 64 2.2e-005 1 R.GYSFTTTAER.E 20065 20066 20068 20069 20070 20071 20072 2007 20828 581.3022 1160.5899 1160.6111 -0.0212 0 53 0.00025 1 K.EITALAPSTMK.I 20826 20827 20829 20830 20831 20832 21089 589.2947 1176.5747 1176.6060 -0.0313 0 (44) 0.0024 1 K.EITALAPSTMK.I 21084 21086 21087 21088 21090 21091 21092 210 21660 599.7649 1197.5153 1197.5150 0.0003 0 68 8.6e-006 1 K.DSYVGDEAQSK.R 21641 21642 21643 21645 21646 21647 21648 21 21686 400.2400 1197.6981 1197.6982 -0.0002 0 30 0.047 1 R.AVFPSIVGRPR.H 21661 21684 21685 21687 21782 602.2856 1202.5567 1202.5536 0.0031 0 31 0.039 1 R.HQGVMVGMGQK.D 21771 21772 21773 21774 21775 21776 21777 217 25164 677.8240 1353.6334 1353.6161 0.0174 1 58 8e-005 1 K.DSYVGDEAQSKR.G 25153 25154 25155 25156 25158 25159 25160 25 26755 506.2429 1515.7068 1515.6954 0.0114 0 43 0.0024 1 K.QEYDESGPSIVHR.K 26750 26751 5200 26752 26753 26754 26756 2 27735 895.9445 1789.8745 1789.8846 -0.0101 0 63 2e-005 1 K.SYELPDGQVITIGNER.F 27734 27962 652.0150 1953.0232 1953.0571 -0.0339 0 40 0.0032 1 R.VAPEEHPVLLTEAPLNPK.A 27961 27963 27964 27965 27966 27967 2

Proteins matching the same set of peptides: P63261|ACTG_HUMAN Mass: 42108 Score: 2622 Queries matched: 209 Actin, cytoplasmic 2 OS=Homo sapiens GN=ACTG1 PE=1 SV=1

10. P04259|K2C6B_HUMAN Mass: 60315 Score: 2504 Queries matched: 213 emPAI: 2.97 Keratin, type II cytoskeletal 6B OS=Homo sapiens GN=KRT6B PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7264 405.1913 808.3681 808.3828 -0.0146 0 28 0.085 1 R.GFSANSAR.L 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 7 11911 441.2298 880.4450 880.4654 -0.0204 0 33 0.022 1 R.SLYGLGGSK.R 11910 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.V 13068 13069 13070 13071 13072 13073 13075 13076 1 14449 473.2554 944.4962 944.5039 -0.0078 1 44 0.0028 1 R.GRLDSELR.N 14428 14430 14432 14435 14436 14437 14438 14439 14773 478.2507 954.4868 954.5134 -0.0266 1 10 5.3 1 R.SEIDHVKK.Q 14796 478.7642 955.5138 955.5814 -0.0676 1 8 8.9 4 K.QDLARLLK.E 14783 15059 483.2539 964.4932 964.4839 0.0094 1 18 0.87 1 R.RGFSANSAR.L 4535 15173 486.7502 971.4859 971.5036 -0.0176 0 49 0.00085 1 K.QEIAEINR.M 16103 503.2325 1004.4505 1004.4597 -0.0092 0 55 0.0002 1 K.LLEGEECR.L 16092 16093 16094 16095 16096 16097 16098 16099 16677 513.7565 1025.4984 1025.5142 -0.0158 0 66 1.3e-005 1 R.SGFSSISVSR.S 16673 16674 16675 16679 17031 519.2945 1036.5745 1036.5665 0.0079 1 24 0.21 1 R.SLYGLGGSKR.I 17027 17028 17029 17030 17160 522.2644 1042.5143 1042.5407 -0.0264 0 35 0.019 1 R.QLDNIVGER.G 18105 533.7516 1065.4887 1065.5090 -0.0204 1 43 0.0025 1 K.YEDEINKR.T 18099 18100 18101 18104 18106 18107 18108 18109 18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 19075 548.7994 1095.5842 1095.6036 -0.0194 1 11 3.7 7 R.LRSEIDHVK.K 19391 554.2758 1106.5370 1106.5356 0.0014 0 60 5.4e-005 1 K.AQYEEIAQR.S 19361 19362 19363 19366 19367 19368 19370 19373 20118 567.2733 1132.5321 1132.5546 -0.0226 1 46 0.0013 1 R.KLLEGEECR.L 20111 20113 20114 20115 20121 20122 20124 2012 20651 576.7691 1151.5236 1151.5458 -0.0223 1 38 0.0087 1 K.NKYEDEINK.R 20648 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.V 21190 590.2897 1178.5649 1178.5931 -0.0282 0 96 1.4e-008 1 K.YEELQITAGR.H 21184 21186 21187 21188 21189 21192 21193 211 6629 600.3358 1198.6571 1198.6418 0.0153 1 6 39 5 R.RQLDNIVGER.G 21693 22035 606.7681 1211.5216 1211.5458 -0.0242 0 52 0.00029 1 R.AEAESWYQTK.Y 22036 22323 611.8088 1221.6030 1221.6241 -0.0211 0 73 2.4e-006 1 R.TAAENEFVTLK.K 22305 22310 22321 24424 439.2287 1314.6644 1314.6891 -0.0248 1 18 0.8 1 R.NTKQEIAEINR.M 24678 665.3538 1328.6930 1328.7187 -0.0257 0 59 6.9e-005 1 R.NLDLDSIIAEVK.A 24677 25066 450.9049 1349.6927 1349.7191 -0.0263 1 46 0.0013 1 R.TAAENEFVTLKK.D 25058 25062 25922 704.3497 1406.6849 1406.7041 -0.0193 0 69 5.4e-006 1 K.ADTLTDEINFLR.A 26083 712.8043 1423.5940 1423.6263 -0.0323 0 95 1.3e-008 1 R.GSGGLGGACGGAGFGSR.S 26085 26202 718.3593 1434.7041 1434.7315 -0.0274 0 77 8.3e-007 1 R.ATGGGLSSVGGGSSTIK.Y 26203 26338 485.8933 1454.6580 1454.6790 -0.0209 1 28 0.068 1 R.SRAEAESWYQTK.Y

11. Q04695|K1C17_HUMAN Mass: 48361 Score: 2116 Queries matched: 153 emPAI: 0.81 Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6205 561.4011 560.3939 560.3282 0.0657 0 10 14 1 K.VISSR.E 7182 404.1948 806.3751 806.3923 -0.0171 0 50 0.00056 1 R.LAADDFR.T 7180 7181 7183 7184 7185 7186 7187 7188 7189 7190 7281 405.2146 808.4146 808.4330 -0.0184 0 48 0.00092 1 R.LASYLDK.V 230 7269 7273 7275 7276 7277 7278 7279 7282 7283 7 8146 417.2127 832.4109 832.4290 -0.0181 0 19 0.81 1 K.SEISELR.R 8144 8145 15275 487.7532 973.4919 973.5080 -0.0160 0 28 0.11 1 R.TIEELQNK.I 15273 15666 495.2607 988.5068 988.5301 -0.0233 1 24 0.25 1 K.SEISELRR.T 15661 15667 15672 15673 15675 15678 15685 15775 497.2464 992.4783 992.4927 -0.0144 0 1 45 9 K.FETEQALR.L 16769 515.2890 1028.5634 1028.5866 -0.0231 0 49 0.0007 1 R.VLDELTLAR.A 5322 16770 16771 5324 5326 16773 16774 16775 16 16939 517.7513 1033.4880 1033.4975 -0.0094 0 12 3.4 3 R.LSGGLGAGSCR.L 17989 532.7985 1063.5825 1063.6026 -0.0200 1 59 6.9e-005 1 R.LASYLDKVR.A 17977 5769 17983 17984 17985 17986 17987 17988 19798 561.7848 1121.5550 1121.5717 -0.0166 0 53 0.00026 1 R.LEQEIATYR.R 19797 21306 593.2736 1184.5327 1184.6877 -0.1550 1 6 14 7 R.RVLDELTLAR.A 24993 673.3259 1344.6372 1344.6772 -0.0400 0 72 3.1e-006 1 R.ALEEANTELEVK.I 24991 24992 24995 24996 25336 681.3382 1360.6618 1360.6834 -0.0216 0 110 4.7e-010 1 R.EVATNSELVQSGK.S 25326 25327 25328 25329 25331 25334 25335 2

12. P13646|K1C13_HUMAN Mass: 49900 Score: 1974 Queries matched: 134 emPAI: 4.64 Keratin, type I cytoskeletal 13 OS=Homo sapiens GN=KRT13 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7182 404.1948 806.3751 806.3923 -0.0171 0 50 0.00056 1 R.LAADDFR.L 7180 7181 7183 7184 7185 7186 7187 7188 7189 7190 7634 412.2241 822.4336 822.4487 -0.0151 0 48 0.00089 1 R.LASYLEK.V 7600 7624 7631 7638 7639 7649 10230 431.2300 860.4454 860.4603 -0.0149 0 45 0.0024 1 K.TEITELR.R 2506 436.2599 870.5052 870.4195 0.0857 0 5 53 3 K.QSPASPER.D 2489 2490 2502 2541 14150 468.2040 934.3935 934.4072 -0.0137 0 21 0.51 1 R.DYSPYYK.T 14151 14152 14964 480.7452 959.4758 959.4924 -0.0166 0 26 0.15 1 R.SLLEGQDAK.M 14965 15098 484.2659 966.5171 966.5399 -0.0228 1 28 0.084 1 K.IRDWHLK.Q 16029 502.2653 1002.5160 1002.5345 -0.0185 1 41 0.0042 1 K.TIEELRDK.I 16019 16022 16024 16031 16034 16146 504.2505 1006.4864 1006.5083 -0.0219 0 47 0.0012 1 K.YENELALR.Q 16361 509.2801 1016.5456 1016.5614 -0.0158 1 18 0.97 1 K.TEITELRR.T 16350 16354

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16369 509.2859 1016.5573 1016.5754 -0.0181 0 48 0.0011 1 R.VLDELTLSK.T 16348 16355 16357 16358 16365 16368 16370 17137 521.7871 1041.5597 1041.5818 -0.0221 0 43 0.0028 1 R.VILEIDNAR.L 17136 17139 17140 18502 539.7557 1077.4968 1077.6182 -0.1214 1 5 17 7 R.LASYLEKVR.A 19231 552.7680 1103.5214 1103.5393 -0.0180 0 68 8.2e-006 1 K.ITMQNLNDR.L 19226 19690 560.7636 1119.5127 1119.5342 -0.0216 0 (64) 2.1e-005 1 K.ITMQNLNDR.L 19688 19798 561.7848 1121.5550 1121.5717 -0.0166 0 53 0.00026 1 R.LEQEIATYR.S 19797 19954 563.7358 1125.4571 1125.4760 -0.0189 0 (46) 0.001 1 R.EQYEAMAER.N 20388 571.7328 1141.4510 1141.4709 -0.0199 0 47 0.00099 1 R.EQYEAMAER.N 20387 20389 20461 572.8087 1143.6029 1143.6248 -0.0218 0 70 6.4e-006 1 K.ILTATIENNR.V 20446 20447 20459 20469 21041 587.3300 1172.6455 1172.6765 -0.0309 1 49 0.00077 1 R.RVLDELTLSK.T 21733 601.3014 1200.5882 1200.6098 -0.0216 0 64 1.9e-005 1 R.QSVEADINGLR.R 21729 21730 21731 21732 21734 22901 416.8965 1247.6678 1247.6873 -0.0195 1 47 0.001 1 R.LKYENELALR.Q 24050 651.3169 1300.6193 1300.6510 -0.0317 0 85 1.3e-007 1 R.ALEEANADLEVK.I 24045 24046 24047 24051 24052 24053 24055 24 25213 453.2353 1356.6841 1356.7110 -0.0269 1 42 0.0029 1 R.QSVEADINGLRR.V 25211 25212 25214 25215 25937 705.3366 1408.6586 1408.6868 -0.0282 0 95 1.2e-008 1 K.EVSTNTAMIQTSK.T 26100 713.3343 1424.6541 1424.6817 -0.0276 0 (91) 3.7e-008 1 K.EVSTNTAMIQTSK.T 26307 725.3226 1448.6306 1448.6565 -0.0259 0 42 0.0025 1 K.AGLENTVAETECR.Y 27728 596.6037 1786.7892 1786.8162 -0.0270 1 19 0.4 1 K.QSPASPERDYSPYYK.T 28206 684.6656 2050.9748 2051.0204 -0.0456 1 81 2.2e-007 1 K.SAELNKEVSTNTAMIQTSK.T 28385 516.7965 2063.1571 2063.0535 0.1036 1 0 24 3 R.LEQEIATYRSLLEGQDAK.M 28407 689.9950 2066.9631 2067.0154 -0.0523 1 (63) 1.3e-005 1 K.SAELNKEVSTNTAMIQTSK.T 28547 716.3067 2145.8983 2145.9498 -0.0515 0 94 7.1e-009 1 R.LQSSSASYGGGFGGGSCQLGGGR.G

13. P62736|ACTA_HUMAN Mass: 42381 Score: 1919 Queries matched: 164 emPAI: 2.01 Actin, aortic smooth muscle OS=Homo sapiens GN=ACTA2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7054 400.7707 799.5268 799.5280 -0.0012 1 26 0.17 1 K.RGILTLK.Y 7044 7045 7047 7048 7049 7050 7051 7052 7053 7055 13624 460.2350 918.4555 918.4593 -0.0038 1 10 6.9 7 K.CDIDIRK.D 13757 462.2761 922.5376 922.5600 -0.0224 1 31 0.045 1 K.IIAPPERK.Y 13752 13753 13755 13756 13758 13759 13760 13761 15332 488.7144 975.4142 975.4410 -0.0268 0 83 2.8e-007 1 K.AGFAGDDAPR.A 15331 15333 15334 15335 15336 15337 15338 1533 15870 499.7448 997.4751 997.4790 -0.0039 0 (25) 0.16 1 R.DLTDYLMK.I 15866 16278 507.7451 1013.4756 1013.4739 0.0017 0 35 0.02 1 R.DLTDYLMK.I 16269 16270 16271 16272 5233 16274 16275 16276 1 17005 518.8265 1035.6383 1035.6440 -0.0057 1 22 0.38 1 K.IKIIAPPER.K 17006 20828 581.3022 1160.5899 1160.6111 -0.0212 0 53 0.00025 1 K.EITALAPSTMK.I 20826 20827 20829 20830 20831 20832 21089 589.2947 1176.5747 1176.6060 -0.0313 0 (44) 0.0024 1 K.EITALAPSTMK.I 21084 21086 21087 21088 21090 21091 21092 210 21660 599.7649 1197.5153 1197.5150 0.0003 0 68 8.6e-006 1 K.DSYVGDEAQSK.R 21641 21642 21643 21645 21646 21647 21648 21 21686 400.2400 1197.6981 1197.6982 -0.0002 0 30 0.047 1 R.AVFPSIVGRPR.H 21661 21684 21685 21687 21782 602.2856 1202.5567 1202.5536 0.0031 0 31 0.039 1 R.HQGVMVGMGQK.D 21771 21772 21773 21774 21775 21776 21777 217 25164 677.8240 1353.6334 1353.6161 0.0174 1 58 8e-005 1 K.DSYVGDEAQSKR.G 25153 25154 25155 25156 25158 25159 25160 25 27735 895.9445 1789.8745 1789.8846 -0.0101 0 63 2e-005 1 K.SYELPDGQVITIGNER.F 27734 28895 472.0473 2355.2004 2355.1529 0.0475 1 4 9.4 1 R.KDLYANNVLSGGTTMYPGIADR.M

Proteins matching the same set of peptides: P63267|ACTH_HUMAN Mass: 42249 Score: 1919 Queries matched: 164 Actin, gamma-enteric smooth muscle OS=Homo sapiens GN=ACTG2 PE=1 SV=1 P68032|ACTC_HUMAN Mass: 42334 Score: 1919 Queries matched: 164 Actin, alpha cardiac muscle 1 OS=Homo sapiens GN=ACTC1 PE=1 SV=1

14. P19012|K1C15_HUMAN Mass: 49395 Score: 1754 Queries matched: 149 emPAI: 1.40 Keratin, type I cytoskeletal 15 OS=Homo sapiens GN=KRT15 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7182 404.1948 806.3751 806.3923 -0.0171 0 50 0.00056 1 R.LAADDFR.L 7180 7181 7183 7184 7185 7186 7187 7188 7189 7190 7281 405.2146 808.4146 808.4330 -0.0184 0 48 0.00092 1 R.LASYLDK.V 230 7269 7273 7275 7276 7277 7278 7279 7282 7283 7 14964 480.7452 959.4758 959.4924 -0.0166 0 26 0.15 1 R.SLLEGQDAK.M 14965 16029 502.2653 1002.5160 1002.5345 -0.0185 1 41 0.0042 1 K.TIEELRDK.I 16019 16022 16024 16031 16034 16146 504.2505 1006.4864 1006.5083 -0.0219 0 47 0.0012 1 K.YENELALR.Q 16769 515.2890 1028.5634 1028.5866 -0.0231 0 49 0.0007 1 R.VLDELTLAR.T 5322 16770 16771 5324 5326 16773 16774 16775 16 17137 521.7871 1041.5597 1041.5818 -0.0221 0 43 0.0028 1 R.VILEIDNAR.L 17136 17139 17140 17989 532.7985 1063.5825 1063.6026 -0.0200 1 59 6.9e-005 1 R.LASYLDKVR.A 17977 5769 17983 17984 17985 17986 17987 17988 19231 552.7680 1103.5214 1103.5393 -0.0180 0 68 8.2e-006 1 K.ITMQNLNDR.L 19226 19690 560.7636 1119.5127 1119.5342 -0.0216 0 (64) 2.1e-005 1 K.ITMQNLNDR.L 19688 19798 561.7848 1121.5550 1121.5717 -0.0166 0 53 0.00026 1 R.LEQEIATYR.S 19797 21306 593.2736 1184.5327 1184.6877 -0.1550 1 6 14 7 R.RVLDELTLAR.T 22901 416.8965 1247.6678 1247.6873 -0.0195 1 47 0.001 1 R.LKYENELALR.Q 1639 428.9253 1283.7541 1283.6299 0.1242 1 3 22 3 R.RDVEAWFFSK.T 24050 651.3169 1300.6193 1300.6510 -0.0317 0 85 1.3e-007 1 R.ALEEANADLEVK.I 24045 24046 24047 24051 24052 24053 24055 24 24638 664.3296 1326.6445 1326.7004 -0.0558 1 1 39 10 R.QGVEADINGLRR.V 25424 684.8112 1367.6079 1367.6139 -0.0060 1 9 5.3 1 R.EQYEAMAEKNR.R 26307 725.3226 1448.6306 1448.6565 -0.0259 0 29 0.061 2 K.AGLENSLAETECR.Y 28385 516.7965 2063.1571 2063.0535 0.1036 1 0 24 3 R.LEQEIATYRSLLEGQDAK.M

15. P02538|K2C6A_HUMAN Mass: 60293 Score: 1704 Queries matched: 208 emPAI: 3.47 Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7264 405.1913 808.3681 808.3828 -0.0146 0 28 0.085 1 R.GFSANSAR.L 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 7 11911 441.2298 880.4450 880.4654 -0.0204 0 33 0.022 1 R.SLYGLGGSK.R 11910 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.V 13068 13069 13070 13071 13072 13073 13075 13076 1 14449 473.2554 944.4962 944.5039 -0.0078 1 44 0.0028 1 R.GRLDSELR.G 14428 14430 14432 14435 14436 14437 14438 14439 14773 478.2507 954.4868 954.5134 -0.0266 1 10 5.3 1 R.SEIDHVKK.Q 14796 478.7642 955.5138 955.5814 -0.0676 1 8 8.9 4 K.QDLARLLK.E 14783 15059 483.2539 964.4932 964.4839 0.0094 1 18 0.87 1 R.RGFSANSAR.L 4535 15173 486.7502 971.4859 971.5036 -0.0176 0 49 0.00085 1 K.QEIAEINR.M 16103 503.2325 1004.4505 1004.4597 -0.0092 0 55 0.0002 1 K.LLEGEECR.L 16092 16093 16094 16095 16096 16097 16098 16099 16236 506.7535 1011.4925 1011.4985 -0.0060 0 65 1.7e-005 1 R.SGFSSVSVSR.S 16229 16230 16231 16232 16233 16234 16237 1623 16333 508.7607 1015.5068 1015.5298 -0.0230 0 53 0.0003 1 R.QLDSIVGER.G 16329 16331 16332 16334 16335 17031 519.2945 1036.5745 1036.5665 0.0079 1 24 0.21 1 R.SLYGLGGSKR.I 17027 17028 17029 17030 18105 533.7516 1065.4887 1065.5090 -0.0204 1 43 0.0025 1 K.YEDEINKR.T 18099 18100 18101 18104 18106 18107 18108 18109

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18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 19075 548.7994 1095.5842 1095.6036 -0.0194 1 11 3.7 7 R.LRSEIDHVK.K 19391 554.2758 1106.5370 1106.5356 0.0014 0 60 5.4e-005 1 K.AQYEEIAQR.S 19361 19362 19363 19366 19367 19368 19370 19373 20118 567.2733 1132.5321 1132.5546 -0.0226 1 46 0.0013 1 R.KLLEGEECR.L 20111 20113 20114 20115 20121 20122 20124 2012 20651 576.7691 1151.5236 1151.5458 -0.0223 1 38 0.0087 1 K.NKYEDEINK.R 20648 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.V 20917 583.2823 1164.5500 1164.5775 -0.0275 0 68 7.5e-006 1 K.YEELQVTAGR.H 20912 20920 20924 20925 21034 586.8087 1171.6028 1171.6309 -0.0281 1 48 0.00079 1 R.RQLDSIVGER.G 6610 599.3185 1196.6225 1196.5383 0.0842 0 4 44 5 R.GMQDLVEDFK.N 21608 21610 6612 6616 22035 606.7681 1211.5216 1211.5458 -0.0242 0 52 0.00029 1 R.AEAESWYQTK.Y 22036 22323 611.8088 1221.6030 1221.6241 -0.0211 0 73 2.4e-006 1 R.TAAENEFVTLK.K 22305 22310 22321 24424 439.2287 1314.6644 1314.6891 -0.0248 1 18 0.8 1 R.NTKQEIAEINR.M 24678 665.3538 1328.6930 1328.7187 -0.0257 0 59 6.9e-005 1 R.NLDLDSIIAEVK.A 24677 25066 450.9049 1349.6927 1349.7191 -0.0263 1 46 0.0013 1 R.TAAENEFVTLKK.D 25058 25062 25922 704.3497 1406.6849 1406.7041 -0.0193 0 69 5.4e-006 1 K.ADTLTDEINFLR.A 26083 712.8043 1423.5940 1423.6263 -0.0323 0 95 1.3e-008 1 R.GSGGLGGACGGAGFGSR.S 26085 26294 724.3722 1446.7298 1446.7678 -0.0380 0 90 4.3e-008 1 R.AIGGGLSSVGGGSSTIK.Y 26293 26338 485.8933 1454.6580 1454.6790 -0.0209 1 28 0.068 1 R.SRAEAESWYQTK.Y 26521 738.8766 1475.7387 1475.7984 -0.0596 1 61 4.1e-005 1 R.FLEQQNKVLETK.W 26520 26522

16. P19013|K2C4_HUMAN Mass: 57649 Score: 1275 Queries matched: 99 emPAI: 7.41 Keratin, type II cytoskeletal 4 OS=Homo sapiens GN=KRT4 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7443 408.7203 815.4260 815.4388 -0.0129 0 43 0.0035 1 R.AEIENIK.K 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 7 14004 466.2369 930.4593 930.4770 -0.0177 0 42 0.0045 1 K.SEIAELNR.M 14002 14007 14405 472.7598 943.5050 943.5338 -0.0288 1 16 1.6 2 R.AEIENIKK.Q 15708 495.7858 989.5571 989.5757 -0.0186 0 52 0.00037 1 K.IISTTTLNK.R 15707 15709 15794 497.7433 993.4721 993.4913 -0.0193 0 47 0.0011 1 K.SISMSVAGSR.Q 15792 16019 502.2498 1002.4850 1002.4982 -0.0132 0 31 0.044 1 K.QLDTLGNDK.G 16056 16176 504.7444 1007.4743 1007.4924 -0.0181 0 35 0.018 1 K.DVDAAYLNK.V 16177 16205 505.7370 1009.4595 1009.4862 -0.0267 0 (44) 0.002 1 K.SISMSVAGSR.Q 16206 16207 16858 516.7535 1031.4924 1031.5247 -0.0323 1 3 32 6 R.TEEREQIK.L 18570 540.7626 1079.5107 1079.5247 -0.0140 1 53 0.00024 1 K.YEEEINKR.T 18677 543.3093 1084.6040 1084.6240 -0.0200 1 49 0.00072 1 R.LRAEIENIK.K 19391 554.2758 1106.5370 1106.5356 0.0014 0 60 5.4e-005 1 R.AQYEEIAQR.S 19361 19362 19363 19366 19367 19368 19370 19373 19840 562.2711 1122.5276 1122.5557 -0.0281 0 56 0.00012 1 K.AEAEALYQTK.V 19839 19959 563.7651 1125.5157 1125.5376 -0.0219 0 44 0.0018 1 R.EYQELMSVK.L 19954 20061 566.2944 1130.5743 1130.5931 -0.0189 1 44 0.0022 1 R.KQLDTLGNDK.G 20127 567.2882 1132.5619 1132.5877 -0.0258 0 43 0.0028 1 K.VQFLEQQNK.V 20249 568.7888 1135.5629 1135.5873 -0.0243 1 65 1.7e-005 1 R.KLLEGEEYR.M 20389 571.7602 1141.5059 1141.5325 -0.0266 0 (39) 0.0074 1 R.EYQELMSVK.L 20388 20504 573.8347 1145.6549 1145.6768 -0.0219 1 48 0.00075 1 K.IISTTTLNKR.R 21014 585.2846 1168.5546 1168.5836 -0.0290 1 52 0.00033 1 R.GENALKDAHSK.R 21015 21549 598.7788 1195.5430 1195.5656 -0.0226 0 2 34 3 R.GFSCGSAIVGGGK.R 21689 600.2552 1198.4958 1198.5176 -0.0218 0 57 0.00011 1 K.TMQDSVEDFK.T 21870 603.8088 1205.6031 1205.6292 -0.0261 0 62 3.1e-005 1 R.TAAENDFVVLK.K 22156 608.2551 1214.4957 1214.5125 -0.0168 0 (43) 0.0023 1 K.TM QDSVEDFK.T 22186 406.2098 1215.6077 1215.6208 -0.0131 1 41 0.0043 1 K.QLDTLGNDKGR.L 23418 635.7709 1269.5273 1269.5772 -0.0499 0 (45) 0.0013 1 R.GAFSSVSMSGGAGR.C 23471 425.5544 1273.6413 1273.6626 -0.0213 1 34 0.02 1 K.NTKSEIAELNR.M 23700 643.7787 1285.5428 1285.5721 -0.0293 0 71 3.8e-006 1 R.GAFSSVSMSGGAGR.C 24812 446.8954 1337.6645 1337.6826 -0.0182 1 44 0.0019 1 R.SKAEAEALYQTK.V 24811 25100 451.5562 1351.6467 1351.6667 -0.0199 1 40 0.0047 1 R.GFSCGSAIVGGGKR.G 25183 452.5854 1354.7344 1354.7568 -0.0224 1 35 0.015 1 K.RVELEAALQQAK.E 25208 679.3359 1356.6573 1356.7249 -0.0676 0 33 0.025 2 R.NLDLDSIIAEVR.A 25203 25204 25206 25207 25911 703.8448 1405.6750 1405.7089 -0.0339 0 88 7.1e-008 1 K.VDSLNDEINFLK.V 26142 476.8852 1427.6339 1427.6602 -0.0263 1 43 0.002 1 K.TMQDSVEDFKTK.Y 26248 481.5562 1441.6467 1441.6732 -0.0265 1 19 0.59 1 K.RGAFSSVSM SGGAGR.C 26268 482.2209 1443.6408 1443.6552 -0.0144 1 (1) 37 4 K.TMQDSVEDFKTK.Y 27275 818.3948 1634.7750 1634.8264 -0.0514 0 93 1.7e-008 1 K.WNLLQQQTTTTSSK.N 27801 607.9752 1820.9039 1820.9381 -0.0342 0 56 0.00011 1 K.VQQLQISVDQHGDNLK.N

17. P09467|F16P1_HUMAN Mass: 37190 Score: 962 Queries matched: 61 emPAI: 3.24 Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8098 416.2560 830.4975 830.4974 0.0001 1 31 0.053 1 K.AISSAVRK.A 8063 8096 8099 8100 10361 434.1990 866.3834 866.3956 -0.0122 0 (22) 0.29 1 R.FVMEEGR.K 10360 10362 10363 11969 442.2024 882.3902 882.3905 -0.0003 0 32 0.029 1 R.FVMEEGR.K 11971 15817 498.2503 994.4860 994.4906 -0.0046 1 (24) 0.2 1 R.FVMEEGRK.A 16220 506.2452 1010.4758 1010.4855 -0.0097 1 35 0.018 1 R.FVMEEGRK.A 16958 518.2888 1034.5631 1034.5760 -0.0129 0 42 0.0033 1 K.HAIIVEPEK.R 20727 579.2762 1156.5378 1156.5764 -0.0386 0 72 3.2e-006 1 K.IYSLNEGYAK.D 20729 20730 20731 20736 20737 20739 20740 2074 22542 411.8714 1232.5922 1232.5972 -0.0050 0 52 0.00033 1 R.YVGSMVADVHR.T 22529 22540 22543 22912 417.2122 1248.6149 1248.5921 0.0228 0 (44) 0.0019 1 R.YVGSMVADVHR.T 931 22911 934 23816 646.3046 1290.5946 1290.5993 -0.0047 0 68 8.5e-006 1 K.FPPDNSAPYGAR.Y 23815 23817 24920 448.2355 1341.6847 1341.6928 -0.0081 1 22 0.26 1 K.GKIYSLNEGYAK.D 24924 26043 473.9029 1418.6869 1418.6942 -0.0074 1 52 0.00028 1 K.KFPPDNSAPYGAR.Y 26044 26045 26328 727.3453 1452.6760 1452.6885 -0.0125 0 84 1.8e-007 1 K.DFDPAVTEYIQR.K 26324 26327 26329 26330 26331 27185 535.9561 1604.8464 1604.8522 -0.0058 0 40 0.0037 1 K.EAVLDVIPTDIHQR.A 27254 543.9269 1628.7588 1628.7642 -0.0054 1 42 0.0025 1 K.STDEPSEKDALQPGR.N 27251 27252 27253 27255 27256 27257 2725 28421 691.3508 2071.0305 2071.0698 -0.0394 0 73 1.3e-006 1 K.AGIAHLYGIAGSTNVTGDQVK.K

18. P63104|1433Z_HUMAN Mass: 27899 Score: 889 Queries matched: 53 emPAI: 0.89 14-3-3 protein zeta/delta OS=Homo sapiens GN=YWHAZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7449 408.7337 815.4527 815.4137 0.0391 0 12 4.9 3 K.LAEQAER.Y 7448 2978 445.2410 888.4674 888.4916 -0.0242 0 9 26 2 R.VVSSIEQK.T

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3528 454.2523 906.4901 906.5174 -0.0274 0 56 0.0003 1 R.NLLSVAYK.N 3518 13194 3524 3529 13198 13199 13200 13201 132 16366 509.2834 1016.5522 1016.5502 0.0020 1 28 0.09 1 R.EKIETELR.D 16356 19898 562.7694 1123.5242 1123.5444 -0.0202 0 22 0.33 1 K.EMQPTHPIR.L 19888 20616 576.2706 1150.5267 1150.5506 -0.0239 0 33 0.025 1 R.YLAEVAAGDDK.K 20619 20621 20622 20623 20624 22969 626.7896 1251.5646 1251.6394 -0.0747 1 10 4.8 2 K.KEMQPTHPIR.L 23541 427.2209 1278.6409 1278.6456 -0.0047 1 62 3.2e-005 1 R.YLAEVAAGDDKK.G 23536 23537 23538 23539 23540 23543 23544 23 24164 652.8416 1303.6687 1303.6772 -0.0085 0 71 3.7e-006 1 K.FLIPNASQAESK.V 24159 24160 24161 24162 24163 24165 26706 502.2640 1503.7701 1503.7780 -0.0079 1 14 1.6 1 R.VVSSIEQKTEGAEK.K 26707 26924 774.8434 1547.6723 1547.7063 -0.0340 0 112 2.8e-010 1 K.SVTEQGAELSNEER.N 26921 26922 26923 26925 26926 26927

19. P60174|TPIS_HUMAN Mass: 26938 Score: 883 Queries matched: 35 emPAI: 1.20 Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9746 425.7316 849.4486 849.4596 -0.0110 0 22 0.45 1 K.VVFEQTK.V 9745 9748 9750 9751 9753 9760 4396 477.7391 953.4636 953.4760 -0.0123 0 15 1.4 1 K.FFVGGNWK.M 20288 569.2905 1136.5664 1136.5648 0.0016 0 62 3.1e-005 1 K.IAVAAQNCYK.V 20279 20281 20282 20284 20285 20286 20287 22568 617.8049 1233.5953 1233.5949 0.0004 0 105 1.6e-009 1 K.SNVSDAVAQSTR.I 22558 22559 22561 22562 22563 22564 22565 22 23133 630.7952 1259.5758 1259.6357 -0.0599 1 8 7.5 2 K.LDEREAGITEK.V 23472 637.8346 1273.6546 1273.6666 -0.0121 1 61 4.2e-005 1 K.VIADNVKDWSK.V 24590 663.8241 1325.6336 1325.6649 -0.0313 0 99 6.3e-009 1 R.IIYGGSVTGATCK.E 24591 4687 486.9100 1457.7081 1457.7151 -0.0070 0 36 0.011 1 R.HVFGESDELIGQK.V 26413 489.5782 1465.7127 1465.7161 -0.0034 0 20 0.39 1 K.TATPQQAQEVHEK.L 26410 26411 26412 27063 529.5818 1585.7237 1585.7307 -0.0071 0 4 16 1 K.DCGATWVVLGHSER.R

20. P21333|FLNA_HUMAN Mass: 283301 Score: 866 Queries matched: 86 emPAI: 0.49 Filamin-A OS=Homo sapiens GN=FLNA PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5383 517.2588 516.2515 516.2908 -0.0393 0 7 53 8 K.VDVGK.D 7307 405.2243 808.4340 808.4265 0.0074 0 13 2.9 1 K.YVICVR.F 8009 415.2386 828.4627 828.4705 -0.0078 0 17 1.4 1 K.AIVDGNLK.L 841 11760 438.2196 874.4247 874.3967 0.0280 0 3 35 10 K.CSGPGLER.A 11886 440.7149 879.4152 879.3756 0.0396 0 1 43 2 R.VTGDDSMR.M 11964 441.7650 881.5155 881.5334 -0.0180 0 3 24 6 K.AGVAPLQVK.V 11963 12202 444.7106 887.4067 887.4422 -0.0356 0 9 7.8 9 R.EEPCLLK.R 14211 469.2573 936.5001 936.4916 0.0085 1 42 0.0032 1 R.VKETADFK.V 14203 14209 14687 476.7434 951.4723 951.4662 0.0061 0 55 0.00014 1 R.AEFTVETR.S 14685 14919 480.1859 958.3573 958.5196 -0.1623 1 3 26 6 K.GAGGQGKVASK.I 15100 484.2707 966.5268 966.5134 0.0133 0 43 0.0026 1 K.VLPTHDASK.V 15097 15638 494.7740 987.5335 987.5349 -0.0014 1 51 0.00048 1 K.KGEITGEVR.M 15633 15636 15637 16160 504.2651 1006.5156 1006.5196 -0.0039 0 40 0.0062 1 K.IQQNTFTR.W 16150 16156 16161 16265 507.2966 1012.5786 1012.5665 0.0121 1 35 0.017 1 K.VKAEGPGLSR.T 16255 16260 16261 16782 515.7248 1029.4350 1029.4437 -0.0087 0 44 0.0025 1 K.SSFTVDCSK.A 16783 16784 16843 516.3077 1030.6008 1030.5155 0.0852 1 3 26 8 K.VTANNDKNR.T 17597 527.2488 1052.4831 1052.4775 0.0057 0 36 0.013 1 R.NDNDTFTVK.Y 5783 533.3118 1064.6091 1064.5325 0.0766 0 23 1.1 1 R.LSPFMADIR.D 18037 18068 18072 5779 18453 538.8571 1075.6996 1075.6866 0.0130 0 17 1 1 K.LKPGAPLRPK.L 18525 540.2897 1078.5649 1078.5520 0.0129 0 64 2.2e-005 1 R.VNVGAGSHPNK.V 18522 18523 18629 542.2755 1082.5365 1082.5284 0.0081 0 26 0.13 1 K.SPFEVYVDK.S 18693 543.7666 1085.5185 1085.5717 -0.0531 0 1 39 3 K.VAQPTITDNK.D 18757 544.7707 1087.5269 1087.5583 -0.0315 0 64 2.2e-005 1 R.TPCEEILVK.H 5974 18769 19036 547.7602 1093.5059 1093.5404 -0.0345 1 9 5.8 1 K.AEISFEDRK.D 19038 6044 19155 550.2907 1098.5669 1098.5669 -0.0000 0 37 0.0094 1 K.GTVEPQLEAR.G 19150 19153 19432 554.7911 1107.5676 1107.5673 0.0003 1 39 0.0071 1 K.RAEFTVETR.S 19433 554.8121 1107.6097 1107.6037 0.0060 0 42 0.0033 1 R.ALTQTGGPHVK.A 20480 573.2790 1144.5434 1144.6452 -0.1018 1 2 38 2 K.GAGSGELKVTVK.G 20532 574.8072 1147.5998 1147.5986 0.0012 0 11 3.8 1 K.ETGEHLVHVK.K 20628 576.3025 1150.5905 1150.6234 -0.0329 1 26 0.12 1 K.DKGEYTLVVK.W 20630 20703 578.3144 1154.6143 1154.6118 0.0025 0 66 1.1e-005 1 K.IVGPSGAAVPCK.V 20952 584.3036 1166.5927 1166.5932 -0.0005 0 55 0.00016 1 K.VPVHDVTDASK.V 21559 598.8199 1195.6252 1195.6197 0.0056 1 51 0.00035 1 R.VKVEPSHDASK.V 21599 599.2699 1196.5253 1196.5211 0.0042 0 35 0.015 1 R.DAPQDFHPDR.V 21569 21570 21574 21576 21578 21589 22384 613.2973 1224.5801 1224.5622 0.0179 0 53 0.00025 1 R.EATTEFSVDAR.A 22396 613.8344 1225.6542 1225.6455 0.0086 0 46 0.0012 1 R.AWGPGLEGGVVGK.S 22448 615.8016 1229.5887 1229.5863 0.0024 0 28 0.087 1 K.AHVVPCFDASK.V 23811 645.8307 1289.6468 1289.6404 0.0063 0 37 0.0084 1 K.YGGQPVPNFPSK.L 24210 436.2492 1305.7257 1305.7153 0.0104 1 8 6.2 1 R.VNVGAGSHPNKVK.V 24382 656.8505 1311.6865 1311.6783 0.0082 0 46 0.0011 1 K.VEPGLGADNSVVR.F 25375 455.5754 1363.7042 1363.6984 0.0059 1 27 0.093 1 K.VDVGKDQEFTVK.S 26148 715.3641 1428.7136 1428.7110 0.0027 0 67 8e-006 1 K.AFGPGLQGGSAGSPAR.F 26192 717.8702 1433.7259 1433.7151 0.0108 0 93 2.3e-008 1 R.ANLPQSFQVDTSK.A 26249 721.8579 1441.7012 1441.6910 0.0103 0 45 0.0013 1 R.AGQSAAGAAPGGGVDTR.D 26997 785.9118 1569.8090 1569.7999 0.0092 0 79 4.9e-007 1 R.GAGTGGLGLAVEGPSEAK.M 27274 545.6261 1633.8564 1633.8536 0.0028 0 22 0.22 1 R.VHGPGIQSGTTNKPNK.F 27361 826.9318 1651.8491 1651.8529 -0.0038 0 50 0.00046 1 K.VTAQGPGLEPSGNIANK.T 27688 882.4380 1762.8615 1762.8486 0.0129 0 62 2.5e-005 1 R.VANPSGNLTETYVQDR.G 27731 597.2689 1788.7850 1788.8213 -0.0364 0 10 3.2 1 K.ATCAPQHGAPGPGPADASK.V 27732

21. Q7Z3Y8|K1C27_HUMAN Mass: 50420 Score: 814 Queries matched: 80 emPAI: 0.33 Keratin, type I cytoskeletal 27 OS=Homo sapiens GN=KRT27 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6205 561.4011 560.3939 560.3282 0.0657 0 10 14 1 K.VLSSR.V 8182 419.2130 836.4115 836.4028 0.0086 0 10 5.2 1 R.LTADDFR.L 8341 421.2299 840.4453 840.4341 0.0112 0 5 15 1 R.VHTVEEK.S 8505 8622 15917 501.2444 1000.4742 1000.5050 -0.0308 1 6 15 4 K.VNNKNEQR.V 17989 532.7985 1063.5825 1063.5662 0.0164 0 44 0.0025 2 R.LASYLENVR.A 5769 17983 17984 17985 17986 17987 17988 17990 18871 545.7505 1089.4864 1089.5237 -0.0373 0 (52) 0.00035 1 K.VTMQNLNDR.L 18872 18873 18875 19284 553.7642 1105.5138 1105.5186 -0.0048 0 65 2e-005 1 K.VTMQNLNDR.L 19265 19266 19267 19268 19270 19272 19273 19274 19466 555.2533 1108.4920 1108.4825 0.0095 0 67 9.1e-006 1 R.DAEAWFNEK.S 19439 19440 19441 19443 19444 19445 19446 19447

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22. P40121|CAPG_HUMAN Mass: 38779 Score: 759 Queries matched: 40 emPAI: 0.91 Macrophage-capping protein OS=Homo sapiens GN=CAPG PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13499 458.7552 915.4959 915.5025 -0.0066 0 34 0.025 1 K.TSTGAPAAIK.K 13503 13505 13507 13508 16511 510.7840 1019.5534 1019.5399 0.0135 0 69 7.1e-006 1 K.ANAQAAALYK.V 16491 16493 16501 16502 16504 16505 16506 1650 17215 522.8052 1043.5959 1043.5975 -0.0016 1 26 0.15 1 K.TSTGAPAAIKK.L 17209 17210 17216 23550 640.8125 1279.6104 1279.6078 0.0025 0 85 1.6e-007 1 K.VSDATGQMNLTK.V 23549 23553 23554 24467 659.2909 1316.5672 1316.5732 -0.0059 0 96 1.1e-008 1 K.EGNPEEDLTADK.A 24459 24463 24464 24465 24466 24468 25074 451.2099 1350.6080 1350.6204 -0.0125 0 44 0.0016 1 K.YQEGGVESAFHK.T 25070 25073 25075 25076 25078 25079 25080

23. P04406|G3P_HUMAN Mass: 36201 Score: 755 Queries matched: 34 emPAI: 0.81 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7133 403.2170 804.4193 804.4243 -0.0049 0 42 0.0045 1 K.VGVNGFGR.I 7130 7131 7132 7134 7135 7326 406.2139 810.4133 810.4058 0.0075 0 12 3 1 K.LTGMAFR.V 7322 7323 7324 7328 766 415.1313 828.2480 828.4341 -0.1861 0 1 35 1 K.QASEGPLK.G 2299 435.2542 868.4938 868.5018 -0.0080 0 32 0.14 1 K.VIPELNGK.L 10577 10775 10817 18075 533.2949 1064.5753 1064.5839 -0.0086 1 42 0.0035 1 K.AGAHLQGGAKR.V 18070 22204 609.3420 1216.6695 1216.5944 0.0751 0 2 33 8 R.VVDLMAHMASK.E 25970 706.3892 1410.7638 1410.7831 -0.0193 0 62 2.8e-005 1 R.GALQNIIPASTGAAK.A 25964 25966 25967 25968 25969 25971 2597 26842 765.8927 1529.7708 1529.7872 -0.0164 0 85 1.2e-007 1 R.VPTANVSVVDLTCR.L 26841 26843 26844 26846 27812 917.4497 1832.8848 1832.9124 -0.0276 0 142 2e-013 1 K.IISNASCTTNCLAPLAK.V 27811

24. P07355|ANXA2_HUMAN Mass: 38808 Score: 733 Queries matched: 55 emPAI: 1.09 Annexin A2 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7262 404.7407 807.4668 807.4603 0.0065 0 25 0.19 1 R.SVPHLQK.V 7250 7252 7254 7255 7258 7260 7557 411.2072 820.3998 820.4000 -0.0002 0 18 0.9 1 R.SEVDMLK.I 7933 414.2231 826.4316 826.4337 -0.0022 1 14 1.8 1 K.VFDRYK.S 7936 8179 419.2051 836.3957 836.3950 0.0008 0 (18) 0.94 1 R.SEVDM LK.I 2625 437.2715 872.5285 872.5517 -0.0232 1 (1) 1.2e+002 4 R.KLMVALAK.G 11892 440.7201 879.4256 879.4338 -0.0082 0 27 0.11 1 R.DLYDAGVK.R 11897 11900 12287 445.2299 888.4452 888.5466 -0.1014 1 2 49 2 R.KLMVALAK.G 4453 479.2655 956.5165 956.4637 0.0528 1 3 63 1 R.LYDSMKGK.G 16989 518.7697 1035.5249 1035.5349 -0.0100 1 38 0.0089 1 R.DLYDAGVKR.K 16990 16992 16995 16996 18687 543.7415 1085.4685 1085.4778 -0.0093 0 58 8.1e-005 1 K.AYTNFDAER.D 18686 18688 18689 18690 18701 543.8194 1085.6242 1085.6743 -0.0501 1 8 7.9 2 K.VLIRIMVSR.S 5965 544.2998 1086.5850 1086.5921 -0.0071 0 4 76 1 R.DALNIETAIK.T 18877 545.7957 1089.5768 1089.5852 -0.0084 1 2 35 8 R.SEVDMLKIR.S 19072 548.7506 1095.4866 1095.4907 -0.0041 0 48 0.00081 1 K.ALLYLCGGDD.- 19068 19509 556.2743 1110.5341 1110.5458 -0.0117 0 64 1.8e-005 1 R.QDIAFAYQR.R 19508 19510 19522 6141 19524 22319 611.7982 1221.5819 1221.5877 -0.0058 0 76 1.3e-006 1 K.TPAQYDASELK.A 22304 22305 22306 22310 22317 22318 22320 22841 622.8110 1243.6073 1243.6156 -0.0083 0 69 7.3e-006 1 R.TNQELQEINR.V 22828 22833 22835 22839 22840 22843 22844 27824 615.6324 1843.8754 1843.8952 -0.0198 0 48 0.00058 1 K.LSLEGDHSTPPSAYGSVK.A

25. P04083|ANXA1_HUMAN Mass: 38918 Score: 723 Queries matched: 56 emPAI: 1.29 Annexin A1 OS=Homo sapiens GN=ANXA1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 841 415.2509 828.4873 828.4957 -0.0083 0 20 1.3 1 K.VLDLELK.G 839 842 844 415.2561 828.4976 828.5069 -0.0093 0 41 0.01 1 R.NALLSLAK.G 8010 837 8013 840 843 846 13217 454.7270 907.4395 907.4399 -0.0004 0 32 0.031 1 R.ALYEAGER.R 13206 13207 13209 13211 13214 13215 13219 13221 3656 458.7441 915.4736 915.4848 -0.0112 0 54 0.00024 1 K.ILVALCGGN.- 3657 13515 3660 13518 13520 3661 13525 13527 13 17973 532.7394 1063.4643 1063.4856 -0.0212 0 54 0.00021 1 R.SEIDMNDIK.A 17977 532.7721 1063.5297 1063.5410 -0.0113 1 26 0.13 1 R.ALYEAGERR.K 17975 17981 17989 22057 607.2741 1212.5337 1212.5259 0.0078 0 63 2.5e-005 1 K.DITSDTSGDFR.N 22051 22052 22053 22054 22055 22056 23188 631.8074 1261.6003 1261.5939 0.0064 0 79 6.7e-007 1 K.TPAQFDADELR.A 23151 23157 23160 23163 23171 23178 23182 231 27600 870.3655 1738.7165 1738.7282 -0.0116 0 88 3.7e-008 1 R.SEDFGVNEDLADSDAR.A 27601 27911 477.0053 1903.9921 1904.0255 -0.0334 1 4 14 1 K.AAYLQETGKPLDETLKK.A 28406 689.9614 2066.8622 2066.8777 -0.0155 1 52 0.00012 1 K.GDRSEDFGVNEDLADSDAR.A

26. P04075|ALDOA_HUMAN Mass: 39851 Score: 659 Queries matched: 62 emPAI: 1.69 Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7079 401.2441 800.4737 800.4756 -0.0018 0 54 0.00032 1 R.ALQASALK.A 7061 23 27 7066 7067 7069 28 7075 7081 7087 7095 9593 422.7643 843.5140 843.5178 -0.0038 1 27 0.15 1 K.SKGGVVGIK.V 9592 9597 9598 14197 469.2331 936.4516 936.4552 -0.0036 0 31 0.043 1 K.AAQEEYVK.R 14199 14200 14271 470.7489 939.4833 939.4774 0.0059 0 58 7.4e-005 1 K.ELSDIAHR.I 14264 14265 14267 14268 14269 14270 14272 15164 486.2947 970.5749 970.5811 -0.0062 1 25 0.17 1 K.GGVVGIKVDK.G 15165 4663 17203 522.7867 1043.5588 1043.5611 -0.0023 0 38 0.0095 1 R.QLLLTADDR.V 18005 533.2445 1064.4745 1064.5039 -0.0295 1 0 47 7 K.DGADFAKWR.C 19011 547.2830 1092.5515 1092.5563 -0.0048 1 58 8.3e-005 1 K.AAQEEYVKR.A 19009 19010 19012 20097 566.7907 1131.5667 1131.5706 -0.0039 0 43 0.0025 1 R.ALANSLACQGK.Y 20096 20098 23745 644.7990 1287.5835 1287.6717 -0.0882 1 5 17 10 K.RALANSLACQGK.Y 24706 666.8516 1331.6886 1331.6932 -0.0046 0 87 1e-007 1 K.GILAADESTGSIAK.R 24702 24703 24704 24705 24707 24708 24921 448.2375 1341.6907 1341.7041 -0.0134 0 18 0.73 1 K.ADDGRPFPQVIK.S 24922 3068 24923 24925 24926 24927 26591 496.9359 1487.7858 1487.7943 -0.0086 1 18 0.59 1 K.GILAADESTGSIAKR.L 26605 745.8532 1489.6919 1489.7008 -0.0089 0 57 8.5e-005 1 R.LQSIGTENTEENR.R 27309 549.6057 1645.7954 1645.8019 -0.0065 1 40 0.0039 1 R.LQSIGTENTEENRR.F 27302 27308 27310 27311 27312

27. P00338|LDHA_HUMAN Mass: 36950 Score: 654 Queries matched: 35 emPAI: 0.97 L-lactate dehydrogenase A chain OS=Homo sapiens GN=LDHA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 831 415.2169 828.4193 828.5069 -0.0876 1 2 77 3 R.TPKIVSGK.D 13387 457.2857 912.5568 912.5756 -0.0188 0 37 0.01 1 K.LVIITAGAR.Q 13382 3640 13386

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13950 465.2874 928.5603 928.5746 -0.0142 0 17 1.3 1 K.FIIPNVVK.Y 13932 13944 13946 13951 16215 506.2367 1010.4588 1010.4669 -0.0081 0 36 0.012 1 K.DYNVTANSK.L 16214 16216 16217 19653 559.7891 1117.5637 1117.5768 -0.0131 0 61 4e-005 1 K.SADTLWGIQK.E 19657 20210 567.7847 1133.5547 1133.5564 -0.0017 0 61 3.9e-005 1 K.VTLTSEEEAR.L 20196 20204 20208 20209 20211 22897 624.8003 1247.5860 1247.5928 -0.0068 0 92 3.5e-008 1 R.VIGSGCNLDSAR.F 22891 22892 22895 22896 22899 22900 23241 632.8392 1263.6639 1263.6711 -0.0072 0 71 3.7e-006 1 K.QVVESAYEVIK.L 23238 23239 23240 26654 499.2634 1494.7683 1494.7678 0.0004 1 34 0.017 1 K.IVSGKDYNVTANSK.L 26655

28. O95678|K2C75_HUMAN Mass: 59809 Score: 652 Queries matched: 124 emPAI: 0.94 Keratin, type II cytoskeletal 75 OS=Homo sapiens GN=KRT75 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 7 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.V 13068 13069 13070 13071 13072 13073 13075 13076 1 13703 461.7357 921.4569 921.4920 -0.0350 0 10 4.8 2 R.SLYNLGGAK.R 13702 16103 503.2325 1004.4505 1004.4597 -0.0092 0 55 0.0002 1 K.LLEGEECR.L 16092 16093 16094 16095 16096 16097 16098 16099 16125 503.7359 1005.4573 1005.4549 0.0024 0 9 6.8 8 K.QEISEMNR.M 16537 511.7377 1021.4608 1021.4498 0.0110 0 (2) 38 9 K.QEISEMNR.M 17061 520.2885 1038.5624 1038.5094 0.0530 0 3 28 8 R.ISSAGASFGSR.S 18105 533.7516 1065.4887 1065.5090 -0.0204 1 43 0.0025 1 R.YEDEINKR.T 18099 18100 18101 18104 18106 18107 18108 18109 5884 540.2496 1078.4847 1078.5043 -0.0196 0 7 27 1 K.AQYEDIANR.S 18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 20118 567.2733 1132.5321 1132.5546 -0.0226 1 46 0.0013 1 R.KLLEGEECR.L 20111 20113 20114 20115 20121 20122 20124 2012 20741 579.2924 1156.5702 1156.6339 -0.0638 0 6 12 8 K.LVDLEEALQK.A 20745 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.V 20917 583.2823 1164.5500 1164.5775 -0.0275 0 68 7.5e-006 1 K.YEELQVTAGR.H 20912 20920 20924 20925 22035 606.7681 1211.5216 1211.5458 -0.0242 0 52 0.00029 1 R.AEAESWYQTK.Y 22036 24678 665.3538 1328.6930 1328.7187 -0.0257 0 59 6.9e-005 1 R.NLDLDSIIAEVK.A 24677 25380 683.3011 1364.5877 1364.6354 -0.0477 1 11 3.5 4 R.NTKQEISEMNR.M 25378 25381 25383 25390 25391 25393 25394 253 26338 485.8933 1454.6580 1454.6790 -0.0209 1 28 0.068 1 R.SRAEAESWYQTK.Y 26521 738.8766 1475.7387 1475.7984 -0.0596 1 61 4.1e-005 1 R.FLEQQNKVLETK.W 26520 26522

29. P07195|LDHB_HUMAN Mass: 36900 Score: 595 Queries matched: 30 emPAI: 0.63 L-lactate dehydrogenase B chain OS=Homo sapiens GN=LDHB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13190 454.2432 906.4717 906.5399 -0.0682 1 5 19 4 K.LSGLPKHR.V 3523 13325 457.2139 912.4132 912.5757 -0.1624 0 4 24 2 K.IVVVTAGVR.Q 3640 14889 479.3055 956.5965 956.6059 -0.0094 0 21 0.47 1 K.FIIPQIVK.Y 14944 480.2752 958.5358 958.5447 -0.0090 0 53 0.00031 1 R.GLTSVINQK.L 14938 14942 14943 14945 14947 20776 579.8144 1157.6142 1157.6292 -0.0150 1 24 0.23 1 K.LKDDEVAQLK.K 20754 21069 588.7907 1175.5669 1175.5822 -0.0153 0 60 6e-005 1 K.SADTLWDIQK.D 21070 22897 624.8003 1247.5860 1247.5928 -0.0068 0 92 3.5e-008 1 R.VIGSGCNLDSAR.F 22891 22892 22895 22896 22899 22900 26727 504.2634 1509.7682 1509.7675 0.0008 1 55 0.00011 1 K.IVADKDYSVTANSK.I 26723 26724 26725 26726 26728 27472 847.9472 1693.8799 1693.8886 -0.0087 0 82 2.1e-007 1 K.LIAPVAEEEATVPNNK.I 27471

30. P05787|K2C8_HUMAN Mass: 53671 Score: 565 Queries matched: 164 emPAI: 0.60 Keratin, type II cytoskeletal 8 OS=Homo sapiens GN=KRT8 PE=1 SV=7 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 79 8084 416.2434 830.4722 830.4974 -0.0252 1 12 4 4 M.SIRVTQK.S 8071 8078 8079 8082 8088 8094 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.M 13068 13069 13070 13071 13072 13073 13075 13076 13 13269 456.2408 910.4671 910.4145 0.0527 0 6 11 1 R.SYTSGPGSR.I 13264 14047 466.7354 931.4562 931.4610 -0.0048 0 57 0.00012 1 K.LLEGEESR.L 14026 14029 14031 14032 14033 14034 14035 14036 1 16344 509.2558 1016.4970 1016.5185 -0.0215 1 9 7.2 3 K.QDMARQLR.E 5387 517.2607 1032.5067 1032.5134 -0.0067 1 (7) 48 2 K.QDMARQLR.E 17829 530.7865 1059.5584 1059.5560 0.0024 1 58 0.00011 1 R.KLLEGEESR.L 17770 17794 17795 17797 17798 17803 17805 17806 18105 533.7516 1065.4887 1065.5090 -0.0204 1 43 0.0025 1 K.YEDEINKR.T 18099 18100 18101 18104 18106 18107 18108 18109 1 5884 540.2496 1078.4847 1078.5043 -0.0196 0 7 27 1 K.AQYEDIANR.S 18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 18638 542.7429 1083.4712 1083.4543 0.0170 0 11 3.8 2 K.DVDEAYMNK.V 18636 5928 20651 576.7691 1151.5236 1151.5458 -0.0223 1 38 0.0087 1 K.NKYEDEINK.R 20648 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.M 22040 606.7916 1211.5687 1211.5492 0.0195 1 12 3.1 2 K.KDVDEAYMNK.V 23702 429.5839 1285.7300 1285.7241 0.0058 1 7 9 2 R.QLETLGQEKLK.L 23701 26462 738.3647 1474.7148 1474.6908 0.0240 0 (17) 0.79 2 R.LESGMQNMSIHTK.T 26466 26468 26469 26470 26471 26472 26473 2

31. P02649|APOE_HUMAN Mass: 36246 Score: 549 Queries matched: 44 emPAI: 0.99 Apolipoprotein E OS=Homo sapiens GN=APOE PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7474 409.1998 816.3851 816.3878 -0.0027 0 16 1.8 1 R.AQAWGER.L 7484 638 412.7598 823.5051 823.5028 0.0024 1 28 0.067 1 R.LASHLRK.L 7838 11535 436.2149 870.4153 870.3211 0.0942 0 1 47 3 R.MEEMGSR.T 12570 450.2298 898.4450 898.4337 0.0113 0 6 12 1 R.FWDYLR.W 13958 465.7529 929.4913 929.4971 -0.0057 0 21 0.5 1 R.QWAGLVEK.V 14560 474.7652 947.5158 947.5188 -0.0030 0 50 0.00055 1 R.LAVYQAGAR.E 14555 14556 14558 14559 14561 14563 15122 484.7761 967.5376 967.5451 -0.0074 0 56 0.00012 1 R.LGPLVEQGR.V 15117 15118 15119 15120 15121 15123 15124 15125 16921 517.2662 1032.5178 1032.5352 -0.0174 0 55 0.00017 1 R.LQAEAFQAR.L 5387 16910 16918 16922 16925 16927 16928 16929 19569 557.7926 1113.5706 1113.5778 -0.0072 0 68 8.8e-006 1 K.LEEQAQQIR.L 19566 19568 24396 657.3515 1312.6883 1312.7099 -0.0215 1 62 3.2e-005 1 R.AKLEEQAQQIR.L 24397 24398 24399 26003 472.2806 1413.8199 1413.7463 0.0735 1 6 11 1 R.LDEVKEQVAEVR.A 27223 810.8943 1619.7740 1619.7904 -0.0164 0 110 3.7e-010 1 K.VQAAVGTSAAPVPSDNH.-

32. P40925|MDHC_HUMAN Mass: 36631 Score: 548 Queries matched: 26 emPAI: 0.98 Malate dehydrogenase, cytoplasmic OS=Homo sapiens GN=MDH1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10303 433.1708 864.3270 864.4375 -0.1105 0 0 51 3 K.LSSAMSAAK.A 10980 435.7161 869.4177 869.4178 -0.0001 0 49 0.00066 1 K.AICDHVR.D 10983 10984

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13495 458.7545 915.4945 915.5025 -0.0081 0 65 1.8e-005 1 K.LGVTANDVK.N 13485 13491 13498 13502 13504 13506 16668 513.7351 1025.4556 1025.4600 -0.0044 0 53 0.00024 1 K.ENFSCLTR.L 16667 16669 16670 16672 20627 576.3011 1150.5877 1150.5982 -0.0105 1 28 0.083 1 K.SQGAALDKYAK.K 20895 582.7991 1163.5837 1163.5935 -0.0098 0 69 7.1e-006 1 K.GEFVTTVQQR.G 20894 20896 20897 20898 20899 25761 697.3461 1392.6776 1392.7038 -0.0261 0 35 0.016 1 K.FVEGLPINDFSR.E 26315 484.2477 1449.7212 1449.7351 -0.0140 1 44 0.002 1 K.DVIATDKEDVAFK.D 27677 879.4446 1756.8747 1756.9142 -0.0395 0 117 7.7e-011 1 K.VIVVGNPANTNCLTASK.S

33. P81605|DCD_HUMAN Mass: 11391 Score: 544 Queries matched: 30 emPAI: 0.82 Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14950 480.6856 959.3566 959.5400 -0.1834 1 4 23 5 K.QRSSLLEK.G 19992 564.7545 1127.4944 1127.5207 -0.0263 0 70 5.2e-006 1 K.ENAGEDPGLAR.Q 19988 19989 19990 19991 19993 19994 19995 19 20819 581.2746 1160.5346 1160.5561 -0.0215 0 55 0.00017 1 K.DAVEDLESVGK.G 20810 20811 20813 20816 20817 20822 20823 208

34. P07737|PROF1_HUMAN Mass: 15216 Score: 516 Queries matched: 32 emPAI: 6.81 Profilin-1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11745 437.7670 873.5194 873.5358 -0.0164 0 54 0.00032 1 K.TLVLLMGK.E 11741 11748 12323 445.7640 889.5135 889.5307 -0.0172 0 (30) 0.064 1 K.TLVLLMGK.E 12311 12313 12316 12324 2991 12325 16572 512.2738 1022.5330 1022.5509 -0.0178 0 48 0.00078 1 K.EGVHGGLINK.K 16570 16571 16573 20633 576.3198 1150.6251 1150.6458 -0.0208 1 40 0.0056 1 K.EGVHGGLINKK.C 20629 20631 20632 20635 22060 607.3002 1212.5858 1212.6139 -0.0281 0 82 2.8e-007 1 K.DSPSVWAAVPGK.T 22059 22061 22063 22064 22238 406.9062 1217.6968 1217.7053 -0.0085 1 30 0.052 1 K.TDKTLVLLMGK.E 22591 412.2360 1233.6862 1233.7003 -0.0141 1 (21) 0.45 1 K.TDKTLVLLMGK.E 25566 690.3562 1378.6978 1378.7093 -0.0115 0 81 3.6e-007 1 K.STGGAPTFNVTVTK.T 25561 25562 25563 25564 26421 735.8711 1469.7276 1469.7515 -0.0238 0 60 4e-005 1 R.SSFYVNGLTLGGQK.C

35. O00299|CLIC1_HUMAN Mass: 27248 Score: 509 Queries matched: 22 emPAI: 0.69 Chloride intracellular channel protein 1 OS=Homo sapiens GN=CLIC1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14827 479.2444 956.4743 956.4715 0.0027 0 43 0.0031 1 R.YLSNAYAR.E 14819 14820 14822 14824 14825 14826 5454 519.2836 1036.5527 1036.5342 0.0185 0 11 16 1 R.GFTIPEAFR.G 18502 539.7557 1077.4968 1077.5026 -0.0057 0 63 3e-005 1 K.IGNCPFSQR.L 18498 18499 18500 18501 18503 23566 641.3311 1280.6477 1280.6613 -0.0136 0 87 8.6e-008 1 K.GVTFNVTTVDTK.R 23565 23567 24659 664.8249 1327.6353 1327.6368 -0.0015 0 78 6.8e-007 1 K.NSNPALNDNLEK.G 24655 24656 24657 24658

36. O76014|KRT37_HUMAN Mass: 51084 Score: 503 Queries matched: 48 emPAI: 0.15 Keratin, type I cuticular Ha7 OS=Homo sapiens GN=KRT37 PE=2 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7182 404.1948 806.3751 806.3923 -0.0171 0 50 0.00056 1 K.LAADDFR.I 7180 7181 7183 7184 7185 7186 7187 7188 7189 7190 719 9754 425.7336 849.4527 849.4596 -0.0069 0 4 26 7 R.LANYLEK.V 9771 15635 494.7690 987.5235 987.5237 -0.0002 0 29 0.081 1 R.TIEELQQK.I 15631

37. P05783|K1C18_HUMAN Mass: 48029 Score: 499 Queries matched: 72 emPAI: 0.08 Keratin, type I cytoskeletal 18 OS=Homo sapiens GN=KRT18 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6196 561.2613 560.2541 560.3282 -0.0741 0 1 1.6e+002 5 R.ISVSR.S 7182 404.1948 806.3751 806.3923 -0.0171 0 50 0.00056 1 R.LAADDFR.V 7180 7181 7183 7184 7185 7186 7187 7188 7189 7190 8182 419.2130 836.4115 836.4392 -0.0277 0 1 39 7 R.LASYLDR.V 15051 483.2353 964.4561 964.4614 -0.0053 0 4 24 4 R.AQYDELAR.K 16071 502.7706 1003.5266 1003.5046 0.0219 1 3 32 5 R.SLETENRR.L 18959 547.2557 1092.4969 1092.5563 -0.0595 1 11 4.4 4 R.AQYDELARK.N 18948 18949 18953 18966 18967 18971 18972 18974 19212 552.2791 1102.5436 1102.5731 -0.0295 1 4 24 1 R.VRSLETENR.R 24484 660.3479 1318.6813 1318.6629 0.0183 0 4 20 9 R.AQIFANTVDNAR.I 24483

38. O76013|KRT36_HUMAN Mass: 53354 Score: 499 Queries matched: 49 emPAI: 0.07 Keratin, type I cuticular Ha6 OS=Homo sapiens GN=KRT36 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6205 561.4011 560.3939 560.3282 0.0657 0 10 14 1 K.VISSR.E 7182 404.1948 806.3751 806.3923 -0.0171 0 50 0.00056 1 K.LAADDFR.T 7180 7181 7183 7184 7185 7186 7187 7188 7189 7190 7 9754 425.7336 849.4527 849.4596 -0.0069 0 4 26 7 R.LANYLEK.V 9771 10230 431.2300 860.4454 860.4603 -0.0149 0 6 18 6 R.TITEEIR.D 20809 581.2581 1160.5016 1160.6037 -0.1021 1 6 12 1 R.TITEEIRDGK.V

39. P12035|K2C3_HUMAN Mass: 64636 Score: 493 Queries matched: 130 emPAI: 1.19 Keratin, type II cytoskeletal 3 OS=Homo sapiens GN=KRT3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 7 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.V 13068 13069 13070 13071 13072 13073 13075 13076 1 13546 459.2501 916.4856 916.4978 -0.0122 1 20 0.62 3 R.GRLDSELK.N 15056 483.2449 964.4752 964.4978 -0.0225 0 28 0.095 1 R.SLYNLGGNK.S 15205 487.2554 972.4962 972.5240 -0.0278 0 20 0.63 2 K.SEIIELNR.M 15217 15218 15224 17040 519.7538 1037.4930 1037.5029 -0.0099 1 23 0.28 1 K.KYEDEINK.R 17260 523.2745 1044.5345 1044.5564 -0.0218 0 26 0.14 1 K.LGELQTTAGR.H 17225 5569 18105 533.7516 1065.4887 1065.5090 -0.0204 1 43 0.0025 1 K.YEDEINKR.T 18099 18100 18101 18104 18106 18107 18108 18109 18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 18986 547.2642 1092.5138 1092.5200 -0.0062 0 24 0.2 1 R.AQYEDIAQR.S 18948 18949 18953 18958 18959 18961 18965 1896 19840 562.2711 1122.5276 1122.5557 -0.0281 0 56 0.00012 1 K.AEAEALYQTK.L 19839 6329 570.2649 1138.5152 1138.5328 -0.0176 0 (19) 1.4 2 R.DYQELMNVK.L 20312 20693 578.2618 1154.5091 1154.5278 -0.0186 0 46 0.0012 1 R.DYQELMNVK.L 20690 20692 20694 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.V 6537 590.2913 1178.5680 1178.5931 -0.0251 0 33 0.099 1 R.SYLDNILGER.G 22323 611.8088 1221.6030 1221.6241 -0.0211 0 73 2.4e-006 1 R.TAAENEFVTLK.K 22305 22310 22321 2917 444.2461 1329.7164 1329.7140 0.0024 0 1 2.1e+002 8 R.SLDLDSIIAEVR.A

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24812 446.8954 1337.6645 1337.6826 -0.0182 1 44 0.0019 1 R.SKAEAEALYQTK.L 24811 24990 673.2925 1344.5705 1344.6058 -0.0353 0 80 4.9e-007 1 R.YGVSGGGFSSASNR.G 25066 450.9049 1349.6927 1349.7191 -0.0263 1 46 0.0013 1 R.TAAENEFVTLKK.D 25058 25062 26521 738.8766 1475.7387 1475.7984 -0.0596 1 61 4.1e-005 1 R.FLEQQNKVLETK.W 26520 26522

40. P06396|GELS_HUMAN Mass: 86043 Score: 489 Queries matched: 63 emPAI: 0.66 Gelsolin OS=Homo sapiens GN=GSN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8221 420.2060 838.3974 838.4007 -0.0033 0 30 0.047 1 R.LFACSNK.I 8220 8224 9764 425.7495 849.4845 849.4709 0.0136 1 39 0.0087 1 K.KGGVASGFK.H 9741 9749 9758 9761 9762 9763 11750 437.7710 873.5274 873.5284 -0.0009 1 34 0.03 1 R.LKATQVSK.G 11743 11751 11754 11954 441.7304 881.4462 881.4494 -0.0033 0 49 0.00056 1 K.TASDFITK.M 11945 11946 11948 11949 11951 11952 11953 11955 12181 444.2474 886.4802 886.4872 -0.0070 0 68 1.2e-005 1 K.TGAQELLR.V 2910 2914 2916 12180 2919 13388 457.2911 912.5676 912.5757 -0.0080 1 27 0.11 1 R.RTPITVVK.Q 13389 13390 13391 13392 18507 539.7603 1077.5061 1077.5091 -0.0030 0 46 0.0014 1 R.YIETDPANR.D 18505 18506 18508 23023 418.8993 1253.6760 1253.6880 -0.0120 1 25 0.17 1 K.AGKEPGLQIWR.V 23021 23022 23484 638.3423 1274.6700 1274.7095 -0.0395 0 32 0.028 1 K.HVVPNEVVVQR.L 23485 23486 23487 23488 23490 24483 660.3456 1318.6766 1318.6881 -0.0115 0 82 3.4e-007 1 K.AGALNSNDAFVLK.T 24480 24482 24484 24505 440.8634 1319.5684 1319.5816 -0.0132 0 18 0.79 1 K.SEDCFILDHGK.D 25045 450.5504 1348.6293 1348.6371 -0.0079 1 17 1.2 1 R.YIETDPANRDR.R 25043 25044 25046 27222 540.8999 1619.6778 1619.7250 -0.0471 1 7 6.1 1 K.SEDCFILDHGKDGK.I 27390 555.9264 1664.7573 1664.7740 -0.0167 1 52 0.00022 1 K.DSQEEEKTEALTSAK.R 27389 27392

41. P52566|GDIR2_HUMAN Mass: 23031 Score: 470 Queries matched: 24 emPAI: 0.59 Rho GDP-dissociation inhibitor 2 OS=Homo sapiens GN=ARHGDIB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9955 428.2514 854.4882 854.4974 -0.0092 0 50 0.00041 1 K.APNVVVTR.L 1574 9926 9929 9931 9934 9936 9944 9947 9949 9957 15073 483.7352 965.4558 965.4719 -0.0161 0 29 0.057 1 K.YVQHTYR.T 15074 15076 15077 24374 656.3496 1310.6845 1310.7082 -0.0237 0 81 4.1e-007 1 K.TLLGDGPVVTDPK.A 24368 24369 24370 24371 24372 24373 24375

42. P62258|1433E_HUMAN Mass: 29326 Score: 469 Queries matched: 32 emPAI: 1.07 14-3-3 protein epsilon OS=Homo sapiens GN=YWHAE PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7449 408.7337 815.4527 815.4137 0.0391 0 12 4.9 3 K.LAEQAER.Y 7448 3528 454.2523 906.4901 906.5174 -0.0274 0 56 0.0003 1 R.NLLSVAYK.N 3518 13194 3524 3529 13198 13199 13200 13201 132 13557 459.2693 916.5240 916.5229 0.0011 0 32 0.042 1 R.IISSIEQK.E 13548 13556 21440 597.7875 1193.5603 1193.5928 -0.0324 0 86 1.3e-007 1 K.EAAENSLVAYK.A 21445 21451 21453 21454 21458 22688 619.3336 1236.6526 1236.6462 0.0064 0 31 0.034 1 K.HLIPAANTGESK.V 23076 628.8002 1255.5858 1255.5833 0.0026 0 45 0.0017 1 R.YLAEFATGNDR.K 25650 462.2359 1383.6859 1383.6783 0.0077 1 53 0.00024 1 R.YLAEFATGNDRK.E 25647 25648 25649 4159 473.2636 1416.7690 1416.7460 0.0231 1 7 38 1 R.IISSIEQKEENK.G

43. Q06830|PRDX1_HUMAN Mass: 22324 Score: 468 Queries matched: 53 emPAI: 2.03 Peroxiredoxin-1 OS=Homo sapiens GN=PRDX1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7511 410.2094 818.4042 818.4134 -0.0091 0 27 0.13 1 R.SVDETLR.L 7503 7504 7505 7508 361 7512 7513 7514 362 7515 75 12219 444.7234 887.4322 887.4389 -0.0066 1 26 0.17 1 K.SKEYFSK.Q 13678 460.7487 919.4829 919.5015 -0.0185 0 40 0.0055 1 R.GLFIIDDK.G 13677 13679 14260 470.7253 939.4360 939.4549 -0.0189 0 22 0.29 1 K.DISLSDYK.G 14258 14259 14261 15450 490.7567 979.4988 979.5239 -0.0251 0 40 0.0057 1 K.IGHPAPNFK.A 15451 15452 15453 15454 15455 15456 19398 554.2938 1106.5730 1106.5972 -0.0242 0 65 1.7e-005 1 R.TIAQDYGVLK.A 19395 19397 19399 19400 19401 19402 19403 1940 19937 563.2776 1124.5407 1124.5713 -0.0306 1 40 0.0053 1 K.DISLSDYKGK.Y 21219 590.7753 1179.5360 1179.5594 -0.0234 0 35 0.015 1 K.ATAVMPDGQFK.D 21218 21555 598.8096 1195.6047 1195.6237 -0.0190 0 62 3.3e-005 1 R.LVQAFQFTDK.H 21551 21552 21553 21554 21556 21557 21973 606.3351 1210.6557 1210.6670 -0.0113 0 49 0.00059 1 R.QITVNDLPVGR.S 21969 21970 21971 21972 6666

44. P41219|PERI_HUMAN Mass: 53732 Score: 465 Queries matched: 63 emPAI: 0.31 Peripherin OS=Homo sapiens GN=PRPH PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12907 452.7349 903.4553 903.4661 -0.0108 1 36 0.015 3 R.LEEETRK.R 12887 12892 12895 12900 12902 12903 12908 12909 12 13608 460.2233 918.4321 918.5035 -0.0715 1 4 26 7 R.LGSFRSPR.A 14047 466.7354 931.4562 931.4610 -0.0048 0 57 0.00012 1 K.LLEGEESR.I 14026 14029 14031 14032 14033 14034 14035 14036 1 17829 530.7865 1059.5584 1059.5560 0.0024 1 58 0.00011 1 R.KLLEGEESR.I 17770 17794 17795 17797 17798 17803 17805 17806 19568 557.7859 1113.5572 1113.6142 -0.0570 1 13 2.7 4 R.ELELLGRER.D 19566 19586 558.2807 1114.5467 1114.5870 -0.0402 0 4 22 2 R.DGLAEDLAALK.Q 24275 655.2977 1308.5808 1308.5986 -0.0178 0 46 0.001 1 K.NLQEAEEWYK.S 24276 24277

45. P08758|ANXA5_HUMAN Mass: 35971 Score: 452 Queries matched: 29 emPAI: 0.82 Annexin A5 OS=Homo sapiens GN=ANXA5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12372 447.2394 892.4641 892.4654 -0.0013 0 20 0.6 1 R.QEISAAFK.T 12371 12852 452.2064 902.3982 902.4821 -0.0839 1 4 25 7 R.ADAETLRK.A 15978 501.2899 1000.5653 1000.5917 -0.0264 0 52 0.00038 1 K.VLTEIIASR.T 15942 15982 15986 15988 15989 15991 16288 507.7625 1013.5105 1013.5069 0.0036 0 35 0.018 1 R.LYDAYELK.H 5234 16283 16285 16287 16289 16290 19307 553.7955 1105.5765 1105.5768 -0.0003 0 35 0.02 1 R.SEIDLFNIR.K 19306 19651 559.7676 1117.5207 1117.5325 -0.0118 0 42 0.0037 1 K.ALLLLCGEDD.- 20698 578.2874 1154.5603 1154.5680 -0.0077 0 82 2.9e-007 1 K.GAGTDDHTLIR.V 20696 20697 20699 20701 22567 412.2050 1233.5932 1233.6717 -0.0785 1 2 36 5 R.SEIDLFNIRK.E 24836 670.8022 1339.5898 1339.6045 -0.0147 0 59 5.7e-005 1 R.GTVTDFPGFDER.A 24837 24839

46. P61981|1433G_HUMAN Mass: 28456 Score: 432 Queries matched: 44 emPAI: 1.12 14-3-3 protein gamma OS=Homo sapiens GN=YWHAG PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7449 408.7337 815.4527 815.4137 0.0391 0 12 4.9 3 R.LAEQAER.Y 7448

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12870 452.2596 902.5046 902.5073 -0.0027 0 42 0.0039 1 R.VISSIEQK.T 12861 12863 12865 12866 12867 12868 12872 12878 3528 454.2523 906.4901 906.5174 -0.0274 0 56 0.0003 1 R.NLLSVAYK.N 3518 13194 3524 3529 13198 13199 13200 13201 132 17176 522.2748 1042.5350 1042.5519 -0.0169 1 29 0.064 2 K.ARLAEQAER.Y 17172 18581 540.7751 1079.5357 1079.5499 -0.0141 0 64 2e-005 1 R.YLAEVATGEK.R 18575 18579 18584 18585 18586 20205 567.7760 1133.5375 1133.5353 0.0022 0 32 0.035 1 K.AYSEAHEISK.E 20200 20206 22681 412.8879 1235.6419 1235.6510 -0.0090 1 33 0.021 1 R.YLAEVATGEKR.A 22678 22679 22680 22682 27297 822.3910 1642.7674 1642.7798 -0.0124 0 85 1.1e-007 1 K.NVTELNEPLSNEER.N 27298

47. Q99456|K1C12_HUMAN Mass: 53592 Score: 422 Queries matched: 79 emPAI: 0.22 Keratin, type I cytoskeletal 12 OS=Homo sapiens GN=KRT12 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7281 405.2146 808.4146 808.4330 -0.0184 0 48 0.00092 1 R.LASYLDK.V 230 7269 7273 7275 7276 7277 7278 7279 7282 7283 7 7380 407.2256 812.4366 812.5232 -0.0866 1 14 1.9 1 R.LLNVKAR.L 16146 504.2505 1006.4864 1006.5083 -0.0219 0 47 0.0012 1 K.YENELALR.Q 17752 530.2829 1058.5513 1058.5972 -0.0459 0 4 22 4 R.VLDELTLTR.T 17989 532.7985 1063.5825 1063.6026 -0.0200 1 59 6.9e-005 1 R.LASYLDKVR.A 17977 5769 17983 17984 17985 17986 17987 17988 19690 560.7636 1119.5127 1119.4978 0.0148 0 27 0.12 3 K.ETMQNLNDR.L 19688 20910 583.2761 1164.5377 1164.6026 -0.0649 0 29 0.066 2 R.LELEIETYR.R 20909 20913 20915 20918 20919 20926 20927 20928 22671 618.7609 1235.5071 1235.6186 -0.1115 1 2 28 6 R.KDAEAWFIEK.S 24638 664.3296 1326.6445 1326.7004 -0.0558 1 1 39 10 R.QGVEADINGLRR.V

48. P06733|ENOA_HUMAN Mass: 47481 Score: 391 Queries matched: 53 emPAI: 1.30 Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7030 400.6943 799.3740 799.3752 -0.0012 0 12 4 1 K.YDLDFK.S 7071 401.2404 800.4662 800.4643 0.0018 0 56 0.0002 1 K.EGLELLK.T 7073 7172 403.7332 805.4518 805.4446 0.0072 0 38 0.011 1 K.YNQLLR.I 7165 7167 7168 7170 7171 7173 12637 450.2758 898.5371 898.5488 -0.0117 0 33 0.026 1 K.TIAPALVSK.K 12576 12622 12636 12638 12640 12641 12907 452.7349 903.4553 903.4549 0.0004 0 51 0.00053 1 R.IEEELGSK.A 12887 12892 12893 12895 12900 12902 12903 12908 14941 480.2695 958.5245 958.5348 -0.0103 1 23 0.33 1 R.NFRNPLAK.- 14967 480.7536 959.4926 959.4924 0.0003 0 45 0.0019 1 K.LNVTEQEK.I 14961 14966 16154 504.2550 1006.4953 1006.4940 0.0014 0 44 0.0025 1 K.SCNCLLLK.V 16143 16147 16153 16157 16903 517.2573 1032.5000 1032.4771 0.0230 1 9 7.6 8 K.TGAPCRSER.L 18641 542.7560 1083.4974 1083.6223 -0.1248 1 2 31 7 -.MSILKIHAR.E 5933 18776 544.8004 1087.5863 1087.5873 -0.0010 1 44 0.0026 1 K.KLNVTEQEK.I 18771 18772 18777 20429 572.3063 1142.5981 1142.6084 -0.0103 0 58 8.5e-005 1 R.IGAEVYHNLK.N 20430 20431 20432 20435 24451 439.5738 1315.6995 1315.6983 0.0011 1 2 30 1 K.LNVTEQEKIDK.L 25912 703.8498 1405.6851 1405.7089 -0.0238 0 85 1.4e-007 1 R.GNPTVEVDLFTSK.G 26107 713.3624 1424.7102 1424.7187 -0.0085 0 43 0.0023 1 R.YISPDQLADLYK.S 27272 817.4002 1632.7858 1632.8141 -0.0283 0 107 8e-010 1 K.VNQIGSVTESLQACK.L

49. O00757|F16P2_HUMAN Mass: 37062 Score: 391 Queries matched: 32 emPAI: 0.62 Fructose-1,6-bisphosphatase isozyme 2 OS=Homo sapiens GN=FBP2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4333 476.2983 475.2910 475.2027 0.0883 0 2 1.1e+002 1 K.NQAGS.- 4285 7512 410.2098 818.4050 818.3705 0.0345 0 2 39 7 K.DALQCGR.N 7508 8098 416.2560 830.4975 830.4974 0.0001 1 31 0.053 1 K.AISSAVRK.A 8063 8096 8099 8100 20727 579.2762 1156.5378 1156.5764 -0.0386 0 72 3.2e-006 1 K.IYSLNEGYAK.Y 20729 20730 20731 20736 20737 20739 20740 2074 22542 411.8714 1232.5922 1232.5972 -0.0050 0 52 0.00033 1 R.YVGSMVADVHR.T 22529 22540 22543 22912 417.2122 1248.6149 1248.5921 0.0228 0 (44) 0.0019 1 R.YVGSMVADVHR.T 931 22911 934 24920 448.2355 1341.6847 1341.6928 -0.0081 1 22 0.26 1 K.GKIYSLNEGYAK.Y 24924

50. P61626|LYSC_HUMAN Mass: 16982 Score: 378 Queries matched: 25 emPAI: 2.43 Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 239 406.1887 810.3628 810.3694 -0.0066 0 (41) 0.013 1 R.LGMDGYR.G 7894 414.1798 826.3450 826.3643 -0.0194 0 47 0.0011 1 R.LGMDGYR.G 7893 7895 7896 7897 7898 7899 718 7900 13254 455.7065 909.3984 909.4015 -0.0031 0 33 0.029 1 R.QYVQGCGV.- 13253 14319 471.6897 941.3648 941.3701 -0.0054 0 21 0.34 1 R.YWCNDGK.T 14318 15698 495.7405 989.4664 989.5328 -0.0664 1 4 26 9 R.CELARTLK.R 17061 520.2885 1038.5624 1038.5934 -0.0310 1 20 0.48 1 R.VVRDPQGIR.A 17059 17063 17064 17066 25874 700.8256 1399.6367 1399.6732 -0.0365 0 84 1.9e-007 1 R.STDYGIFQINSR.Y 25873 25875 25876 25877

51. Q5VTE0|EF1A3_HUMAN Mass: 50495 Score: 365 Queries matched: 45 emPAI: 0.53 Putative elongation factor 1-alpha-like 3 OS=Homo sapiens GN=EEF1AL3 PE=5 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8227 420.2271 838.4396 838.4436 -0.0040 0 30 0.052 1 K.EVSTYIK.K 8228 11058 435.7598 869.5050 869.5334 -0.0284 0 7 8.8 1 K.QLIVGVNK.M 12386 447.7400 893.4655 893.4858 -0.0203 1 28 0.09 1 R.TIEKFEK.E 12384 12387 12389 12390 12391 12392 13417 457.7839 913.5533 913.5597 -0.0064 0 46 0.0013 1 R.QTVAVGVIK.A 13403 13404 13511 458.7702 915.5258 915.5138 0.0120 1 16 1.7 9 K.NVSVKDVR.R 15101 484.2729 966.5313 966.5386 -0.0073 1 23 0.27 1 K.EVSTYIKK.I 15096 15103 15328 488.2755 974.5364 974.5437 -0.0072 0 27 0.14 1 R.LPLQDVYK.I 15325 15327 16660 513.3060 1024.5974 1024.6030 -0.0055 0 72 2.9e-006 1 K.IGGIGTVPVGR.V 16644 16646 16647 16648 16649 5298 16650 1665 19691 560.7902 1119.5659 1119.5924 -0.0266 0 41 0.0046 1 K.STTTGHLIYK.C 19692 19693 19694 19695 19696 19697 20470 573.2364 1144.4582 1144.6492 -0.1910 0 5 16 8 R.GITIDISLWK.F

Proteins matching the same set of peptides: P68104|EF1A1_HUMAN Mass: 50451 Score: 365 Queries matched: 45 Elongation factor 1-alpha 1 OS=Homo sapiens GN=EEF1A1 PE=1 SV=1

52. P13796|PLSL_HUMAN Mass: 70815 Score: 364 Queries matched: 43 emPAI: 0.75 Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7904 414.2101 826.4056 826.4007 0.0050 0 16 1.2 1 K.YAISMAR.K 7915 7936 7957 7962

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8645 421.7145 841.4145 841.4181 -0.0036 0 17 0.95 1 K.SSSISSFK.D 12852 452.2064 902.3982 902.4457 -0.0475 1 10 5.9 1 R.EKDDIQR.A 14334 471.7708 941.5270 941.5334 -0.0064 0 37 0.011 1 R.VNKPPYPK.L 14326 14327 14332 14335 14337 15796 497.7602 993.5058 993.5131 -0.0073 0 43 0.003 1 K.IGNFSTDIK.D 15795 15874 499.7597 997.5048 997.5120 -0.0072 0 15 1.6 1 R.ISFDEFIK.I 4995 18167 535.3042 1068.5938 1068.6179 -0.0241 0 13 2.7 2 K.LSPEELLLR.W 18781 545.2342 1088.4539 1088.4557 -0.0018 0 63 3e-005 1 K.ALENDPDCR.H 18780 18782 18783 18784 18791 19620 559.2908 1116.5671 1116.5750 -0.0079 0 21 0.5 1 K.AACLPLPGYR.V 20238 568.3026 1134.5907 1134.6033 -0.0126 0 50 0.00061 1 R.QFVTATDVVR.G 20236 6302 20237 21268 591.7976 1181.5806 1181.5928 -0.0122 1 41 0.0035 1 K.SSSISSFKDPK.I 21267 21269 22646 618.2753 1234.5361 1234.5434 -0.0073 0 (44) 0.002 1 R.AECMLQQAER.L 22950 626.2641 1250.5137 1250.5383 -0.0246 0 47 0.00088 1 R.AECMLQQAER.L 22952 22954 24571 442.2265 1323.6578 1323.6670 -0.0092 1 26 0.12 1 K.IGNFSTDIKDSK.A 25935 705.3262 1408.6379 1408.6656 -0.0277 0 59 5.2e-005 1 K.LENCNYAVELGK.N 25938 26876 513.2633 1536.7681 1536.7606 0.0075 1 38 0.0064 1 K.KLENCNYAVELGK.N 27057 793.4155 1584.8164 1584.8399 -0.0235 0 10 3.7 1 R.VYALPEDLVEVNPK.M 27214 539.9273 1616.7600 1616.7641 -0.0042 1 44 0.0015 1 K.TENLNDDEKLNNAK.Y 27213

53. Q7Z794|K2C1B_HUMAN Mass: 61935 Score: 351 Queries matched: 62 emPAI: 0.34 Keratin, type II cytoskeletal 1b OS=Homo sapiens GN=KRT77 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 79 4554 483.7431 965.4716 965.4930 -0.0214 0 19 0.62 2 R.SLYNLGGSR.S 15078 4573 484.2320 966.4494 966.4658 -0.0165 0 20 1.2 1 K.DVDAAYVSK.V 15091 15721 496.2610 990.5074 990.4804 0.0270 0 4 20 3 K.MEIAELNR.T 17829 530.7865 1059.5584 1059.5196 0.0388 0 58 0.00011 1 R.QLLEGEESR.M 17770 17794 17795 17797 17798 17803 17805 17806 18105 533.7516 1065.4887 1065.5090 -0.0204 1 43 0.0025 1 K.YEDEINKR.T 18099 18100 18101 18104 18106 18107 18108 18109 1 19238 552.7742 1103.5339 1103.5645 -0.0306 0 6 16 6 R.EQIMVLNNK.F 19761 561.2936 1120.5726 1120.5876 -0.0150 0 20 0.59 1 R.TQYELIAQR.S 19727 19728 19736 19738 19749 20023 565.3209 1128.6272 1128.6502 -0.0230 1 5 18 7 R.LQAEISNVKK.Q 24720 668.3405 1334.6665 1334.7082 -0.0417 0 25 0.16 1 R.VDTLTGEVNFLK.Y 24764 446.2427 1335.7061 1335.7034 0.0027 1 2 27 5 R.TGSENDFVVLKK.D 25625 461.5539 1381.6400 1381.6725 -0.0325 1 36 0.01 1 R.SKDEAEALYQTK.Y

54. P27348|1433T_HUMAN Mass: 28032 Score: 349 Queries matched: 36 emPAI: 0.88 14-3-3 protein theta OS=Homo sapiens GN=YWHAQ PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7449 408.7337 815.4527 815.4137 0.0391 0 12 4.9 3 K.LAEQAER.Y 7448 12870 452.2596 902.5046 902.5073 -0.0027 0 42 0.0039 1 R.VISSIEQK.T 12861 12863 12865 12866 12867 12868 12872 12878 3528 454.2523 906.4901 906.5174 -0.0274 0 56 0.0003 1 R.NLLSVAYK.N 3518 13194 3524 3529 13198 13199 13200 13201 132 15663 495.2590 988.5035 988.5189 -0.0154 1 34 0.022 1 R.EKVESELR.S 15680 19898 562.7694 1123.5242 1123.5444 -0.0202 0 22 0.33 1 K.EMQPTHPIR.L 19888 22969 626.7896 1251.5646 1251.6394 -0.0747 1 10 4.8 2 K.KEMQPTHPIR.L 25822 466.2239 1395.6499 1395.6452 0.0047 1 31 0.032 1 R.YLAEVACGDDRK.Q 25821 26851 766.8584 1531.7023 1531.7114 -0.0091 0 104 1.6e-009 1 K.AVTEQGAELSNEER.N 26850 26852

55. P11142|HSP7C_HUMAN Mass: 71082 Score: 345 Queries matched: 24 emPAI: 0.66 Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7126 402.7253 803.4360 803.4389 -0.0028 0 24 0.29 1 K.ITITNDK.G 10151 429.7296 857.4447 857.4494 -0.0048 0 23 0.37 1 R.GTLDPVEK.A 10152 13969 465.7696 929.5247 929.5294 -0.0047 1 16 1.5 2 K.RNTTIPTK.Q 14412 472.7649 943.5153 943.5161 -0.0008 0 21 0.54 1 K.VCNPIITK.L 14411 15664 495.2593 988.5039 988.5189 -0.0149 1 41 0.0048 1 R.LSKEDIER.M 15662 15671 16367 509.2841 1016.5536 1016.5614 -0.0079 1 53 0.00028 1 K.ITITNDKGR.L 16348 18610 541.2840 1080.5535 1080.5604 -0.0069 0 8 8.1 1 K.LLQDFFNGK.E 21225 590.8114 1179.6083 1179.6135 -0.0052 1 36 0.013 1 K.VQVEYKGETK.S 6628 600.3327 1198.6509 1198.6670 -0.0161 0 42 0.0094 1 K.DAGTIAGLNVLR.I 6625 22410 614.8084 1227.6023 1227.6207 -0.0184 0 65 1.7e-005 1 K.VEIIANDQGNR.T 22412 22413 24479 660.3006 1318.5866 1318.5863 0.0002 0 51 0.00036 1 K.NSLESYAFNMK.A 26111 476.2296 1425.6671 1425.6558 0.0113 1 15 1.2 1 R.RFDDAVVQSDMK.H 26581 744.3471 1486.6797 1486.6940 -0.0143 0 63 2.1e-005 1 R.TTPSYVAFTDTER.L 26582 27391 833.3905 1664.7665 1664.7828 -0.0163 0 73 1.6e-006 1 K.NQVAMNPTNTVFDAK.R 27466 564.5765 1690.7077 1690.7183 -0.0106 0 30 0.034 1 K.STAGDTHLGGEDFDNR.M

56. P37837|TALDO_HUMAN Mass: 37688 Score: 338 Queries matched: 41 emPAI: 1.58 Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7881 413.7705 825.5265 825.5324 -0.0059 0 23 0.2 1 K.LVPVLSAK.A 703 704 7882 7883 7884 1484 425.2390 848.4634 848.4756 -0.0122 1 46 0.0051 1 R.KFAADAVK.L 9728 9729 10251 432.2150 862.4154 862.4225 -0.0071 0 24 0.29 1 K.IYNYYK.K 10254 10257 10261 2634 438.2268 874.4391 874.4508 -0.0118 1 3 75 8 K.EAGISKDR.I 11788 438.7241 875.4336 875.4349 -0.0013 0 43 0.0039 1 R.VSTEVDAR.L 11789 11793 14148 467.7838 933.5530 933.5647 -0.0117 1 16 1.6 1 R.RLIELYK.E 14149 15471 491.2646 980.5147 980.5113 0.0033 0 (8) 8.4 1 K.TIVMGASFR.N 15721 496.2610 990.5074 990.5174 -0.0100 1 15 1.9 1 K.IYNYYKK.F 15855 499.2609 996.5073 996.5063 0.0011 0 27 0.087 1 K.TIVMGASFR.N 4983 17962 532.2882 1062.5618 1062.5491 0.0127 1 14 2.5 1 K.LERMLTER.M 17961 18361 537.7791 1073.5437 1073.5353 0.0084 0 77 1.3e-006 1 K.LGGSQEDQIK.N 18359 18360 21763 601.8201 1201.6256 1201.6302 -0.0047 1 10 5.1 3 R.KLGGSQEDQIK.N 22069 607.3392 1212.6638 1212.6714 -0.0076 0 62 3.1e-005 1 K.LLGELLQDNAK.L 22067 22535 617.3006 1232.5866 1232.5925 -0.0059 0 52 0.00033 1 K.SYEPLEDPGVK.S 22532 22534 22536 22537 23498 638.8278 1275.6410 1275.6459 -0.0049 0 57 9.7e-005 1 K.LSSTWEGIQAGK.E 23497 25343 681.3460 1360.6774 1360.6874 -0.0100 1 6 12 4 K.KSYEPLEDPGVK.S 25744 696.8605 1391.7063 1391.7119 -0.0055 0 71 3.5e-006 1 K.ALAGCDFLTISPK.L 26408 733.8332 1465.6519 1465.7413 -0.0894 1 5 12 3 R.VSTEVDARLSFDK.D

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57. Q5XKE5|K2C79_HUMAN Mass: 58059 Score: 327 Queries matched: 95 emPAI: 0.64 Keratin, type II cytoskeletal 79 OS=Homo sapiens GN=KRT79 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 7 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.V 13068 13069 13070 13071 13072 13073 13075 13076 1 14449 473.2554 944.4962 944.5039 -0.0078 1 44 0.0028 1 R.GRLDSELR.N 14428 14430 14432 14435 14436 14437 14438 14439 16294 508.2092 1014.4039 1014.5822 -0.1783 1 0 52 6 K.EDLTRLLR.D 18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 19433 554.8121 1107.6097 1107.5884 0.0213 1 5 15 6 K.TTTVKTSSQR.Y 6329 570.2649 1138.5152 1138.5328 -0.0176 0 (19) 1.4 2 R.DYQELMNVK.L 20312 20651 576.7691 1151.5236 1151.5458 -0.0223 1 38 0.0087 1 K.NKYEDEINK.H 20648 20693 578.2618 1154.5091 1154.5278 -0.0186 0 46 0.0012 1 R.DYQELMNVK.L 20690 20692 20694 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.V 21802 602.8013 1203.5880 1203.6207 -0.0327 1 13 2.4 1 R.STLDRLQSER.G 24678 665.3538 1328.6930 1328.7187 -0.0257 0 59 6.9e-005 1 R.NLDLDSIIAEVK.A 24677 26521 738.8766 1475.7387 1475.7984 -0.0596 1 61 4.1e-005 1 R.FLEQQNKVLETK.W 26520 26522

58. P31946|1433B_HUMAN Mass: 28179 Score: 323 Queries matched: 41 emPAI: 1.13 14-3-3 protein beta/alpha OS=Homo sapiens GN=YWHAB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7449 408.7337 815.4527 815.4137 0.0391 0 12 4.9 3 K.LAEQAER.Y 7448 12870 452.2596 902.5046 902.5073 -0.0027 0 42 0.0039 1 R.VISSIEQK.T 12861 12863 12865 12866 12867 12868 12872 12878 3528 454.2523 906.4901 906.5174 -0.0274 0 56 0.0003 1 R.NLLSVAYK.N 3518 13194 3524 3529 13198 13199 13200 13201 132 19898 562.7694 1123.5242 1123.5444 -0.0202 0 22 0.33 1 K.EMQPTHPIR.L 19888 21265 591.7848 1181.5551 1181.5564 -0.0013 0 63 2.5e-005 1 R.YLSEVASGDNK.Q 21258 21260 21261 21262 21264 22969 626.7896 1251.5646 1251.6394 -0.0747 1 10 4.8 2 K.KEMQPTHPIR.L 25312 680.8554 1359.6961 1359.7034 -0.0073 0 41 0.0042 1 K.YLIPNATQPESK.V 27098 799.8630 1597.7114 1597.7332 -0.0218 0 67 8.1e-006 1 K.AVTEQGHELSNEER.N 27096 27097 27099 27100

59. P26038|MOES_HUMAN Mass: 67892 Score: 320 Queries matched: 52 emPAI: 1.90 Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7050 400.7659 799.5172 799.4916 0.0256 1 13 3.2 3 M.PKTISVR.V 7048 7052 7316 405.7042 809.3937 809.3919 0.0018 0 35 0.015 1 K.SGYLAGDK.L 8066 416.2327 830.4509 830.4359 0.0151 1 10 7.9 6 R.QGNTKQR.I 8157 417.2436 832.4727 832.4694 0.0033 0 34 0.025 1 K.ESPLLFK.F 945 8180 419.2056 836.3967 836.4028 -0.0061 0 21 0.42 1 R.NISFNDK.K 11879 440.6947 879.3748 879.4007 -0.0260 1 28 0.1 6 R.EMAEKEK.E 12178 444.2471 886.4796 886.4872 -0.0076 0 23 0.34 1 K.EALLQASR.D 3041 447.7733 893.5321 893.5375 -0.0054 0 10 5.1 1 R.LFFLQVK.E 13511 458.7702 915.5258 915.5138 0.0120 1 46 0.0015 1 K.KVTAQDVR.K 13509 14503 474.2476 946.4806 946.4906 -0.0099 0 45 0.002 1 R.ISQLEMAR.Q 14493 14498 14504 14948 480.2915 958.5684 958.5851 -0.0167 0 21 0.46 1 K.FVIKPIDK.K 15006 481.2858 960.5571 960.5644 -0.0072 1 31 0.051 1 R.KESPLLFK.F 15005 15024 482.2444 962.4742 962.4855 -0.0113 0 (32) 0.037 1 R.ISQLEM AR.Q 15062 483.2559 964.4973 964.4978 -0.0005 1 18 0.88 1 R.NISFNDKK.F 15060 4776 488.7723 975.5300 975.5389 -0.0089 0 25 0.21 1 K.QLFDQVVK.T 15420 489.7847 977.5549 977.4851 0.0698 1 5 17 4 R.AMLENEKK.K 15417 15577 494.2563 986.4981 986.5032 -0.0052 0 42 0.0041 1 R.ALELEQER.K 15575 15576 15578 15599 16019 502.2498 1002.4850 1002.5345 -0.0495 1 8 9.5 3 K.QIEEQTKK.A 17309 523.2836 1044.5527 1044.5563 -0.0036 0 47 0.0013 1 K.ALTSELANAR.D 18365 537.7919 1073.5693 1073.5716 -0.0024 1 16 1.5 1 R.AQSEAEKLAK.E 18519 540.2545 1078.4943 1078.4964 -0.0021 1 27 0.11 1 R.EKEELMER.L 18520 18524 540.2808 1078.5471 1078.5546 -0.0075 0 44 0.0022 1 R.EDAVLEYLK.I 18730 544.3424 1086.6703 1086.6801 -0.0098 1 35 0.018 1 K.FVIKPIDKK.A 19436 554.8241 1107.6336 1107.6400 -0.0064 1 47 0.001 1 R.VLEQHKLNK.D 19596 558.3001 1114.5857 1114.5982 -0.0125 1 36 0.012 1 R.ALELEQERK.R 19599 19615 558.8161 1115.6176 1115.6186 -0.0010 1 22 0.37 1 R.LKQIEEQTK.K 20425 572.3015 1142.5884 1142.6043 -0.0160 1 34 0.023 1 R.RALELEQER.K 6548 591.7980 1181.5814 1181.5869 -0.0055 0 38 0.0074 1 K.APDFVFYAPR.L 21850 603.7850 1205.5554 1205.5598 -0.0044 0 38 0.0086 1 K.AQM VQEDLEK.T 22468 616.2982 1230.5818 1230.5840 -0.0022 0 58 9.5e-005 1 K.AQQELEEQTR.R 22530 617.2881 1232.5617 1232.5673 -0.0056 0 46 0.0012 1 K.ESEAVEWQQK.A 22541 411.8713 1232.5922 1232.6050 -0.0129 0 7 10 1 R.IQVWHEEHR.G 22676 412.8716 1235.5930 1235.5935 -0.0004 1 34 0.018 1 K.YGDFNKEVHK.S 25303 680.3443 1358.6740 1358.6790 -0.0050 1 78 7.5e-007 1 K.KAQQELEEQTR.R 25693 694.4110 1386.8074 1386.6851 0.1223 1 1 34 7 K.AQQELEEQTRR.A 26590 496.9333 1487.7780 1487.7766 0.0014 1 6 9.4 1 R.RKPDTIEVQQMK.A

60. P14618|KPYM_HUMAN Mass: 58470 Score: 319 Queries matched: 32 emPAI: 0.54 Pyruvate kinase isozymes M1/M2 OS=Homo sapiens GN=PKM2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5271 510.3047 509.2974 509.3214 -0.0239 0 5 13 1 R.VVPVP.- 8262 420.7630 839.5114 839.5229 -0.0114 0 14 1.8 1 R.APIIAVTR.N 8259 12018 442.7366 883.4585 883.4698 -0.0112 0 9 5.7 7 R.MQHLIAR.E 14087 467.2579 932.5013 932.5154 -0.0141 0 26 0.18 1 R.GIFPVLCK.D 3932 15700 495.7549 989.4953 989.5029 -0.0076 0 34 0.025 1 K.GSGTAEVELK.K 16455 510.2513 1018.4880 1018.5083 -0.0203 0 43 0.003 1 K.GDYPLEAVR.M 16457 5269 16465 16468 16469 19660 559.8053 1117.5960 1117.5979 -0.0019 1 65 1.7e-005 1 K.GSGTAEVELKK.G 19656 19659 19661 20383 571.3040 1140.5934 1140.6026 -0.0093 0 51 0.00038 1 R.GDLGIEIPAEK.V 6353 20367 20370 20371 20375 20377 20380 2038 21616 599.3149 1196.6153 1196.6401 -0.0248 0 71 3.6e-006 1 R.LDIDSPPITAR.N 21614 21617 21618 25304 680.3494 1358.6842 1358.6976 -0.0134 0 66 1.2e-005 1 R.NTGIICTIGPASR.S

61. Q9NSB2|KRT84_HUMAN Mass: 65938 Score: 308 Queries matched: 97 emPAI: 0.32 Keratin, type II cuticular Hb4 OS=Homo sapiens GN=KRT84 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 79 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.L 13068 13069 13070 13071 13072 13073 13075 13076 13 14047 466.7354 931.4562 931.4610 -0.0048 0 57 0.00012 1 R.LLEGEESR.L 14026 14029 14031 14032 14033 14034 14035 14036 1 15051 483.2353 964.4561 964.4614 -0.0053 0 7 12 1 K.AQYEEVAR.R 15309 488.2272 974.4398 974.4062 0.0336 1 4 29 4 -.MSCRSYR.V 16344 509.2558 1016.4970 1016.5185 -0.0215 1 9 7.2 3 K.QDMARQLR.E 5387 517.2607 1032.5067 1032.5134 -0.0067 1 (7) 48 2 K.QDMARQLR.E 17034 519.7261 1037.4377 1037.5869 -0.1492 1 3 27 5 R.LKAEIEHAK.A 18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 18765 544.7793 1087.5440 1087.5621 -0.0182 1 32 0.035 1 R.RLLEGEESR.L 18733 18758 18764 18768 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.L 25224 453.5649 1357.6728 1357.7202 -0.0474 0 0 47 4 R.VAPATGDLLSTGTR.S

62. P00918|CAH2_HUMAN Mass: 29285 Score: 306 Queries matched: 40 emPAI: 1.07 Carbonic anhydrase 2 OS=Homo sapiens GN=CA2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3956 468.2387 934.4628 934.4509 0.0120 0 35 0.046 1 K.GGPLDGTYR.L 14153 14154 14155 14158 14160 14162 14163 15520 492.7946 983.5746 983.5764 -0.0017 0 45 0.0015 1 K.VGSAKPGLQK.V 15514 15515 15516 15517 4857 15518 4858 15519 15583 494.2758 986.5371 986.5648 -0.0278 0 43 0.0032 1 K.VVDVLDSIK.T 15582 4902 4903 4904 15587 4907 15598 21003 585.2594 1168.5042 1168.5149 -0.0107 0 56 0.00012 1 K.SADFTNFDPR.G 21000 21001 21002 21004 21005 21007 21008 2100 24367 437.8902 1310.6487 1310.6467 0.0021 0 22 0.27 1 R.QSPVDIDTHTAK.Y 24359 24361 24365 24427 658.3522 1314.6898 1314.7031 -0.0133 0 40 0.0053 1 K.EPISVSSEQVLK.F 24428

63. P07864|LDHC_HUMAN Mass: 36630 Score: 305 Queries matched: 36 emPAI: 0.10 L-lactate dehydrogenase C chain OS=Homo sapiens GN=LDHC PE=2 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1149 421.7494 841.4842 841.5022 -0.0179 0 13 2.7 1 K.ISGLPVTR.V 8646 8743 8832 8847 8881 8978 1224 8999 9007 9043 9657 424.2230 846.4314 846.3831 0.0483 0 3 37 10 R.QQEGETR.L 22897 624.8003 1247.5860 1247.5928 -0.0068 0 92 3.5e-008 1 R.VIGSGCNLDSAR.F 22891 22892 22895 22896 22899 22900

64. P52209|6PGD_HUMAN Mass: 53619 Score: 301 Queries matched: 24 emPAI: 0.50 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens GN=PGD PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7077 401.2430 800.4714 800.4756 -0.0042 0 51 0.00062 1 K.VVGAQSLK.E 7072 7076 7078 7083 7084 7086 9885 427.8103 853.6061 853.6113 -0.0052 1 19 0.41 2 R.RIILLVK.A 11696 437.7455 873.4764 873.4668 0.0096 1 8 12 9 K.IRDSAGQK.G 11863 440.2273 878.4400 878.4498 -0.0098 0 12 3.5 2 K.SFLEDIR.K 11895 440.7214 879.4282 879.4603 -0.0321 0 1 44 5 K.EAWPHIK.T 15504 492.7397 983.4649 983.4713 -0.0063 1 39 0.0066 1 K.FQFDGDKK.S 15509 4856 16162 504.2741 1006.5337 1006.5447 -0.0110 1 31 0.04 1 K.SFLEDIRK.A 19726 561.2747 1120.5348 1120.5400 -0.0052 0 55 0.00017 1 K.VDDFLANEAK.G 19723 19724 19725 21385 596.7958 1191.5770 1191.5772 -0.0002 0 66 1.4e-005 1 K.AGQAVDDFIEK.L 21381 21383 21386 27086 796.3968 1590.7790 1590.8002 -0.0212 0 86 9.3e-008 1 K.GILFVGSGVSGGEEGAR.Y

65. P07197|NFM_HUMAN Mass: 102468 Score: 299 Queries matched: 40 emPAI: 0.04 Neurofilament medium polypeptide OS=Homo sapiens GN=NEFM PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7906 414.2126 826.4107 826.4225 -0.0118 0 9 6.9 7 R.FAGYIEK.V 7905 7908 721 7934 7938 8021 415.7139 829.4132 829.4592 -0.0460 1 4 33 8 K.RSMLAPR.L 13628 460.2388 918.4631 918.4770 -0.0139 1 4 26 8 R.GTKESLER.Q 14484 473.7737 945.5328 945.4767 0.0561 0 8 9.6 6 K.LLEGEETR.F 16034 502.2660 1002.5174 1002.4982 0.0193 0 13 3.1 4 K.LTEAAEQNK.E 16014 16015 16024 16029 16031 18073 533.2790 1064.5435 1064.4886 0.0548 1 1 43 10 K.ERFEEEAR.L 19757 561.2916 1120.5687 1120.5764 -0.0077 0 59 6.5e-005 1 R.EYQDLLNVK.M 19721 19722 19732 19735 19737 19741 19742 19743 6483 586.3518 1170.6890 1170.5703 0.1187 0 2 79 3 R.ATLEMVNHEK.A 21547 598.7748 1195.5350 1195.6448 -0.1098 1 2 28 6 K.SPVPKSPVEEK.G

66. P23528|COF1_HUMAN Mass: 18719 Score: 296 Queries matched: 20 emPAI: 0.45 Cofilin-1 OS=Homo sapiens GN=CFL1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7415 408.2296 814.4447 814.3895 0.0552 0 1 50 10 K.MIYASSK.D 13462 458.2550 914.4955 914.5073 -0.0117 0 21 0.57 1 K.NIILEEGK.E 13457 3653 17143 522.2257 1042.4369 1042.6022 -0.1653 1 1 39 1 K.KNIILEEGK.E 21252 591.2888 1180.5630 1180.5798 -0.0168 0 7 11 1 K.AVLFCLSEDK.K 24283 437.2271 1308.6594 1308.6748 -0.0154 1 27 0.085 1 K.AVLFCLSEDKK.N 24282 2590 24284 24774 669.3092 1336.6038 1336.6187 -0.0149 0 66 1e-005 1 R.YALYDATYETK.E 24768 24769 24770 24771 24772 24773 24775 24849 447.5548 1339.6427 1339.7711 -0.1284 0 2 26 3 K.LGGSAVISLEGKPL.- 24868

67. P15924|DESP_HUMAN Mass: 334021 Score: 296 Queries matched: 79 emPAI: 0.17 Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6229 562.3277 561.3204 561.2983 0.0221 1 4 69 1 R.SGSRR.G 52 402.2135 802.4124 802.4225 -0.0100 0 13 16 1 R.LWDLEK.Q 7441 408.7057 815.3968 815.4249 -0.0281 1 14 3.2 3 R.ERENLR.Q 365 410.2307 818.4468 818.4650 -0.0183 0 13 6.3 1 K.LVFDGLR.K 7565 411.2394 820.4642 820.4807 -0.0164 1 11 5 1 K.ILEYKR.Q 922 416.7254 831.4362 831.4450 -0.0088 0 7 15 4 K.VTQLTDR.W 967 418.7377 835.4609 835.4803 -0.0194 0 6 17 3 K.VSYVQLK.E 1767 431.7451 861.4756 861.4960 -0.0204 0 13 3.7 1 R.GLVGIEFK.E 11776 438.2519 874.4893 874.5310 -0.0416 1 6 17 5 R.AMTIAKLK.T 11781 11996 442.2604 882.5063 882.4521 0.0542 0 5 14 2 R.FLSEMLK.S 11992 12210 444.7157 887.4169 887.4348 -0.0180 0 25 0.21 1 R.LEDELNR.A 12312 445.7445 889.4744 889.4505 0.0239 1 11 5.6 6 K.IESEREK.S 12778 451.7433 901.4721 901.5120 -0.0399 0 7 15 7 K.LASLEELK.R 12755 13197 454.2551 906.4957 906.5174 -0.0217 0 40 0.0055 1 R.YIELLTR.S 13187 13202 13496 458.7546 915.4946 915.5138 -0.0192 1 4 23 7 K.GLQDSIRK.K

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13510 458.7679 915.5212 915.5389 -0.0177 1 11 5.2 3 R.SLKEQAIK.I 13570 459.7397 917.4649 917.4818 -0.0169 0 39 0.0088 1 R.ISTEEAIR.K 13623 460.2348 918.4550 918.4811 -0.0260 0 22 0.37 1 K.NFVDPVTK.K 13632 460.2399 918.4652 918.5320 -0.0668 1 7 13 4 K.IRAMTIAK.L 13611 13629 13739 462.2239 922.4332 922.4396 -0.0064 0 5 18 9 R.LEYDDLR.R 13781 462.7374 923.4602 923.4825 -0.0222 0 22 0.32 1 R.DVLDGHLR.E 13954 465.7433 929.4721 929.4930 -0.0209 0 26 0.17 1 R.AQIDNLTR.E 3898 466.2658 930.5170 930.5750 -0.0579 1 5 54 7 K.TTLDKLLK.G 14021 14022 14108 467.3438 932.6730 932.5179 0.1551 0 1 31 4 K.TVSVSEAIK.K 14113 467.7255 933.4365 933.4953 -0.0588 1 2 36 9 K.KMSAAEAVK.E 14323 471.7342 941.4538 941.5294 -0.0757 0 5 18 4 R.QVQNLVNK.S 14465 473.2642 944.5139 944.5291 -0.0152 0 37 0.013 1 K.LTVDSAIAR.D 4167 473.7153 945.4161 945.5243 -0.1082 1 4 23 3 R.VSQERTVK.D 14645 476.2371 950.4597 950.4345 0.0252 0 4 22 3 K.AEFQEEAK.R 15094 484.2549 966.4953 966.5175 -0.0222 0 19 0.68 1 K.AFIGFEGVK.G 15378 488.7455 975.4765 975.4621 0.0144 1 7 14 1 K.EDDSKNLR.N 4975 498.3006 994.5867 994.5560 0.0307 1 5 42 3 K.QDQKIVHK.G 15994 501.7586 1001.5027 1001.5142 -0.0114 0 8 9.9 4 K.VQEQELTR.L 16072 502.7713 1003.5280 1003.5549 -0.0270 0 43 0.0028 1 R.LLEAASVSSK.G 16112 503.2598 1004.5050 1004.5291 -0.0241 0 14 2.6 1 K.FLDQNLQK.Y 16280 507.7473 1013.4801 1013.5505 -0.0705 0 1 46 6 K.QQLEVELR.Q 16352 509.2736 1016.5326 1016.5502 -0.0176 0 29 0.084 1 K.ISITEGIER.G 16347 16348 16544 511.7558 1021.4971 1021.5193 -0.0221 0 56 0.00015 1 K.YGDGIQLTR.S 16545 17309 523.2836 1044.5527 1044.5564 -0.0037 0 10 6.1 4 R.GIVDSITGQR.L 17284 5569 17304 17737 530.2631 1058.5117 1058.5468 -0.0352 1 2 34 3 K.QRTQEELR.R 18103 533.7499 1065.4852 1065.5706 -0.0854 1 3 25 5 K.EKYSLVEAK.R 18291 537.2763 1072.5381 1072.5513 -0.0131 0 44 0.0028 1 R.GAGSIAGASASPK.E 19255 553.2552 1104.4958 1104.5775 -0.0816 1 1 48 6 R.AKSTLEAETR.V 19371 554.2602 1106.5059 1106.5356 -0.0297 1 6 15 5 K.AEFQEEAKR.R 19637 559.7093 1117.4041 1117.4393 -0.0352 0 1 30 5 -.MSCNGGSHPR.I 20022 565.2993 1128.5839 1128.6026 -0.0187 0 48 0.00095 1 K.IEVLEEELR.L 20057 566.2683 1130.5221 1130.5469 -0.0248 0 30 0.056 1 R.GIHNSIGDYR.W 20315 570.3274 1138.6402 1138.6597 -0.0195 0 41 0.0038 1 R.AELIVQPELK.Y 6329 20312 20313 20314 20502 573.8107 1145.6068 1145.6292 -0.0224 0 47 0.0011 1 R.LQSLTENLTK.E 20921 583.2843 1164.5540 1164.5775 -0.0235 0 63 2.4e-005 1 K.IQSQFTDAQK.H 22987 627.7910 1253.5674 1253.5928 -0.0254 0 45 0.0014 1 K.AITGFDDPFSGK.T 23337 633.3648 1264.7150 1264.6524 0.0626 1 3 26 1 K.YGDGIQLTRSR.E 23623 642.3409 1282.6672 1282.5976 0.0696 1 24 0.18 2 K.DMLANFRGSEK.Y 23621 23622 25359 681.8514 1361.6882 1361.7588 -0.0706 1 6 10 10 K.SLLATMKTELQK.A 3736 461.2158 1380.6255 1380.6707 -0.0452 1 1 1.9e+002 7 K.CYGQIKELNEK.I 25669 694.3462 1386.6778 1386.7103 -0.0325 0 71 3.6e-006 1 R.LNDSILQATEQR.R 26490 738.3901 1474.7656 1474.8143 -0.0487 1 8 7.5 9 R.FQNSLKELQLQK.Q 31432 454.2085 2719.2070 2719.3599 -0.1529 1 1 14 4 K.SVQNDSQAIAEVLNQLKDMLANFR.G

68. Q8N1N4|K2C78_HUMAN Mass: 57629 Score: 274 Queries matched: 67 emPAI: 0.46 Keratin, type II cytoskeletal 78 OS=Homo sapiens GN=KRT78 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.V 13068 13069 13070 13071 13072 13073 13075 13076 1 14534 474.3400 946.6655 946.5018 0.1637 1 0 37 1 R.MAKQNLAR.L 15436 490.2548 978.4950 978.5022 -0.0072 0 33 0.03 1 K.DVDGVFLSK.M 4821 16103 503.2325 1004.4505 1004.4597 -0.0092 0 55 0.0002 1 R.LLEGEECR.M 16092 16093 16094 16095 16096 16097 16098 16099 16155 504.2550 1006.4955 1006.5195 -0.0240 1 16 1.3 1 R.ARYEEIAR.S 19840 562.2711 1122.5276 1122.5557 -0.0281 0 56 0.00012 1 K.AEAEALYQTK.Y 19839 20812 581.2684 1160.5222 1160.5608 -0.0385 1 21 0.39 1 R.RLLEGEECR.M 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.V 21346 594.8168 1187.6190 1187.6510 -0.0319 1 12 3.3 2 R.LQSQTENLKK.Q 6924 692.3581 1382.7016 1382.6249 0.0768 0 2 93 4 R.SLNSFGGCLEGSR.G 26521 738.8766 1475.7387 1475.7984 -0.0596 1 61 4.1e-005 1 R.FLEQQNKVLETK.W 26520 26522

69. P60660|MYL6_HUMAN Mass: 17090 Score: 272 Queries matched: 13 emPAI: 0.85 Myosin light polypeptide 6 OS=Homo sapiens GN=MYL6 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15840 498.2954 994.5763 994.5811 -0.0048 0 67 9.9e-006 1 R.HVLVTLGEK.M 15838 15839 16622 513.2509 1024.4871 1024.4978 -0.0106 0 34 0.017 1 K.EAFQLFDR.T 16624 16625 16631 935 417.2178 1248.6314 1248.5768 0.0546 0 2 1.7e+002 1 K.EGNGTVMGAEIR.H 25168 677.8545 1353.6944 1353.7252 -0.0308 0 72 3.1e-006 1 R.ALGQNPTNAEVLK.V 25166 25167 25169 25170

70. P37802|TAGL2_HUMAN Mass: 22548 Score: 270 Queries matched: 23 emPAI: 1.56 Transgelin-2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7527 410.7147 819.4149 819.4239 -0.0090 0 37 0.013 1 R.GPAYGLSR.E 7523 7524 7525 7526 7528 7529 7531 15470 491.2504 980.4863 980.5152 -0.0289 0 2 29 6 K.DVGRPQPGR.E 16235 506.7479 1011.4812 1011.5059 -0.0247 0 29 0.061 1 K.IQASTMAFK.Q 19477 555.2967 1108.5789 1108.6101 -0.0312 1 12 2.9 1 R.KDVGRPQPGR.E 21762 601.8048 1201.5950 1201.6237 -0.0287 0 (36) 0.013 1 K.NVIGLQMGTNR.G 22219 609.8062 1217.5978 1217.6187 -0.0208 0 48 0.00083 1 K.NVIGLQMGTNR.G 22474 616.3348 1230.6551 1230.6754 -0.0203 0 47 0.0012 1 R.TLMNLGGLAVAR.D 22471 22473 23533 640.2897 1278.5649 1278.5840 -0.0192 0 63 2.1e-005 1 R.NFSDNQLQEGK.N 23530 23531 23532 23534 23535 31012 535.2824 2671.3754 2671.3098 0.0657 1 1 15 1 K.IQASTMAFKQMEQISQFLQAAER.Y

71. P02768|ALBU_HUMAN Mass: 71317 Score: 258 Queries matched: 55 emPAI: 0.50 Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11780 438.2548 874.4950 874.5025 -0.0075 1 22 0.44 1 R.LSQRFPK.A 11901 440.7257 879.4369 879.4338 0.0032 0 41 0.0046 1 K.AEFAEVSK.L 11882 11884 11885 11887 11889 11890 11891 11893 3822 464.2415 926.4685 926.4861 -0.0176 0 34 0.059 1 K.YLYEIAR.R 3817 3818 13832 13834 13835 13836 13837 3825 3826 14255 470.7212 939.4277 939.4410 -0.0132 0 30 0.05 1 K.DDNPNLPR.L 4490 480.7848 959.5551 959.5552 -0.0002 0 9 8.9 1 K.FQNALLVR.Y

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15505 492.7399 983.4652 983.4811 -0.0159 0 38 0.0079 1 K.TYETTLEK.C 15502 15503 15507 15901 500.7671 999.5197 999.5964 -0.0768 0 11 5.3 2 K.QTALVELVK.H 15900 16263 507.2907 1012.5668 1012.5917 -0.0248 0 30 0.046 1 K.LVAASQAALGL.- 18341 537.7553 1073.4961 1073.5353 -0.0391 1 39 0.0082 1 K.LDELRDEGK.A 18344 18348 18355 20542 575.2878 1148.5611 1148.6077 -0.0466 0 34 0.019 1 K.LVNEVTEFAK.T 20541 20543 20544 20545 20546 20548 6907 679.8946 1357.7747 1357.6224 0.1523 0 4 20 2 K.AVMDDFAAFVEK.C 25498 686.2805 1370.5465 1370.5595 -0.0130 0 14 1.3 1 K.AAFTECCQAADK.A 26256 722.3184 1442.6223 1442.6347 -0.0125 0 61 3.2e-005 1 K.YICENQDSISSK.L 26253 26254 26255 26257 26660 749.7885 1497.5625 1497.5712 -0.0087 0 53 0.00011 1 K.TCVADESAENCDK.S

72. P62937|PPIA_HUMAN Mass: 18229 Score: 253 Queries matched: 17 emPAI: 1.62 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens GN=PPIA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9676 424.7048 847.3951 847.4076 -0.0125 0 31 0.056 1 K.TEWLDGK.H 9674 9675 9677 9678 17626 528.2678 1054.5210 1054.5335 -0.0125 0 33 0.024 1 R.VSFELFADK.V 17627 6180 560.3019 1118.5892 1118.5278 0.0615 0 29 0.27 1 K.ITIADCGQLE.- 6406 577.7819 1153.5493 1153.5655 -0.0162 0 34 0.021 1 K.FEDENFILK.H 20685 20686 6407 22876 624.3116 1246.6087 1246.6227 -0.0140 1 73 2.4e-006 1 K.KITIADCGQLE.- 22869 22872 22874 22875

73. P08107|HSP71_HUMAN Mass: 70294 Score: 242 Queries matched: 26 emPAI: 0.29 Heat shock 70 kDa protein 1 OS=Homo sapiens GN=HSPA1A PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7126 402.7253 803.4360 803.4389 -0.0028 0 24 0.29 1 K.ITITNDK.G 12783 451.7448 901.4751 901.4756 -0.0005 0 19 0.83 1 R.STLEPVEK.A 12764 12765 16040 502.2697 1002.5249 1002.5345 -0.0096 1 22 0.33 1 R.LSKEEIER.M 16017 16023 16048 16367 509.2841 1016.5536 1016.5614 -0.0079 1 53 0.00028 1 K.ITITNDKGR.L 16348 20064 566.7435 1131.4724 1131.5771 -0.1047 1 14 2.2 2 K.SAVEDEGLKGK.I 20067 20283 569.2792 1136.5438 1136.5462 -0.0024 1 54 0.00021 1 K.YKAEDEVQR.E 20278 21589 599.2598 1196.5049 1196.6877 -0.1828 0 15 1.4 2 K.DAGVIAGLNVLR.I 21599 21612 21807 602.8245 1203.6345 1203.5255 0.1090 0 1 39 4 K.GGSGSGPTIEEVD.- 22410 614.8084 1227.6023 1227.6207 -0.0184 0 65 1.7e-005 1 K.VEIIANDQGNR.T 22412 22413 22800 621.7717 1241.5288 1241.6979 -0.1691 1 6 13 3 R.STLEPVEKALR.D 22900 624.8016 1247.5886 1247.6292 -0.0406 1 1 37 9 R.AMTKDNNLLGR.F 26581 744.3471 1486.6797 1486.6940 -0.0143 0 63 2.1e-005 1 R.TTPSYVAFTDTER.L 26582 27405 559.2395 1674.6967 1674.7234 -0.0267 0 28 0.055 1 K.ATAGDTHLGGEDFDNR.L

74. P08238|HS90B_HUMAN Mass: 83554 Score: 241 Queries matched: 29 emPAI: 0.30 Heat shock protein HSP 90-beta OS=Homo sapiens GN=HSP90AB1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8014 415.2597 828.5048 828.5221 -0.0173 0 21 0.54 1 R.ALLFIPR.R 845 11876 440.2568 878.4991 878.4167 0.0823 0 3 33 3 R.EMLQQSK.I 12321 445.7473 889.4800 889.4141 0.0659 1 3 31 4 K.AEADKNDK.A 12336 446.2224 890.4302 890.4174 0.0128 0 12 3.7 1 K.FYEAFSK.N 14625 476.2285 950.4424 950.4570 -0.0146 0 12 3.9 1 R.ADHGEPIGR.G 14611 14681 17049 520.2436 1038.4725 1038.4869 -0.0144 0 41 0.0047 1 R.YESLTDPSK.L 17322 523.2848 1044.5551 1044.5927 -0.0377 1 14 2.1 5 K.VEKVTISNR.L 17277 17278 17292 17298 17318 20365 571.2812 1140.5478 1140.5523 -0.0045 0 40 0.0055 1 K.LGIHEDSTNR.R 20355 20618 576.2741 1150.5337 1150.5506 -0.0169 0 48 0.00073 1 K.YIDQEELNK.T 20617 20802 580.7716 1159.5287 1159.5761 -0.0474 0 42 0.0034 1 K.SIYYITGESK.E 20805 21468 597.8150 1193.6154 1193.6404 -0.0250 0 28 0.071 1 K.IDIIPNPQER.T 21471 22805 621.8444 1241.6742 1241.6979 -0.0238 0 50 0.00051 1 K.ADLINNLGTIAK.S 22906 625.3046 1248.5946 1248.6098 -0.0152 0 79 5.9e-007 1 K.EQVANSAFVER.V 22907 23481 638.3155 1274.6164 1274.6354 -0.0189 0 3 23 1 R.ELISNASDALDK.I 23960 433.2193 1296.6360 1296.6534 -0.0175 1 3 20 1 K.LGIHEDSTNRR.R 3998 470.2263 1407.6570 1407.6881 -0.0311 1 16 3.1 1 K.EKYIDQEELNK.T

75. Q9H299|SH3L3_HUMAN Mass: 10488 Score: 239 Queries matched: 15 emPAI: 0.38 SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14133 467.7528 933.4911 933.4516 0.0395 0 2 40 2 K.SQQSEVTR.I 17656 528.7626 1055.5106 1055.5248 -0.0141 0 66 1.5e-005 1 R.VYSTSVTGSR.E 17643 17646 17648 17649 17650 17652 17653 1765 21753 401.2393 1200.6961 1200.5921 0.1040 1 5 16 2 R.DEMRALAGNPK.A 21743

76. O15511|ARPC5_HUMAN Mass: 16367 Score: 229 Queries matched: 9 emPAI: 0.24 Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens GN=ARPC5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 46 402.2011 802.3876 802.4297 -0.0421 1 3 1.5e+002 5 K.SQAVKDR.A 14574 475.2321 948.4496 948.4988 -0.0492 1 9 7.1 1 M.SKNTVSSAR.F 14576 18183 535.8160 1069.6175 1069.6244 -0.0069 0 85 1.6e-007 1 K.ALAAGGVGSIVR.V 18178 18179 18180 18181 18182

77. P22392|NDKB_HUMAN Mass: 17401 Score: 228 Queries matched: 20 emPAI: 0.49 Nucleoside diphosphate kinase B OS=Homo sapiens GN=NME2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 751 414.7594 827.5043 827.5116 -0.0074 0 20 0.54 1 R.GLVGEIIK.R 749 753 754 17578 526.2532 1050.4918 1050.4917 0.0002 0 58 7.2e-005 1 R.GDFCIQVGR.N 17561 5644 17566 17570 17572 17573 18155 535.2742 1068.5338 1068.5564 -0.0225 0 34 0.02 1 R.NIIHGSDSVK.S 18159 18160 18162 18164 18166 24987 448.9206 1343.7400 1343.7561 -0.0161 0 9 5.7 1 R.TFIAIKPDGVQR.G 24986 3108

78. P54652|HSP72_HUMAN Mass: 70263 Score: 227 Queries matched: 19 emPAI: 0.29 Heat shock-related 70 kDa protein 2 OS=Homo sapiens GN=HSPA2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7126 402.7253 803.4360 803.4389 -0.0028 0 24 0.29 1 K.ITITNDK.G 2563 436.7519 871.4892 871.4651 0.0241 0 5 23 8 R.GTLEPVEK.A 12657 450.7636 899.5126 899.5076 0.0050 0 13 3 1 R.VVSEGGKPK.V 12649 12650 12651 12653 13969 465.7696 929.5247 929.5294 -0.0047 1 16 1.5 2 K.RNTTIPTK.Q

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16367 509.2841 1016.5536 1016.5614 -0.0079 1 53 0.00028 1 K.ITITNDKGR.L 16348 18610 541.2840 1080.5535 1080.5604 -0.0069 0 8 8.1 1 K.LLQDFFNGK.E 21225 590.8114 1179.6083 1179.6135 -0.0052 1 36 0.013 1 K.VQVEYKGETK.T 22035 606.7681 1211.5216 1211.6874 -0.1658 1 8 6.5 8 R.GTLEPVEKALR.D 22410 614.8084 1227.6023 1227.6207 -0.0184 0 65 1.7e-005 1 K.VEIIANDQGNR.T 22412 22413 26581 744.3471 1486.6797 1486.6940 -0.0143 0 63 2.1e-005 1 R.TTPSYVAFTDTER.L 26582 27466 564.5765 1690.7077 1690.7183 -0.0106 0 30 0.034 1 K.STAGDTHLGGEDFDNR.M

79. Q3SY84|K2C71_HUMAN Mass: 57727 Score: 221 Queries matched: 38 emPAI: 0.46 Keratin, type II cytoskeletal 71 OS=Homo sapiens GN=KRT71 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7906 414.2126 826.4107 826.4225 -0.0118 0 46 0.0013 1 K.FASFIDK.V 7905 7908 7909 7910 7913 721 7916 7917 7918 7920 7 14617 476.2244 950.4343 950.5185 -0.0843 0 12 3.5 2 R.SLYSLGGVR.S 14614 14615 14629 14635 14646 14649 14921 480.1971 958.3797 958.4832 -0.1035 1 1 47 4 R.GDNALKDAR.A 15072 483.7342 965.4538 965.4454 0.0084 0 1 43 9 K.DVDAAYANK.V 18570 540.7626 1079.5107 1079.5247 -0.0140 1 53 0.00024 1 R.YEEEINKR.T 18619 541.7911 1081.5676 1081.5920 -0.0244 1 44 0.002 1 K.FASFIDKVR.F 18620 19177 551.3056 1100.5967 1100.5938 0.0029 1 1 40 4 R.LDSELRNVR.D 19840 562.2711 1122.5276 1122.5557 -0.0281 0 56 0.00012 1 K.AEAEALYQTK.F 19839 24281 437.2210 1308.6411 1308.6925 -0.0514 1 15 1.5 1 R.TQYEEIALKSK.A 24812 446.8954 1337.6645 1337.6826 -0.0182 1 44 0.0019 1 K.SKAEAEALYQTK.F 24811 25713 695.8308 1389.6471 1389.7616 -0.1145 1 0 40 5 K.RTAAENEFVLLK.K 26521 738.8766 1475.7387 1475.7620 -0.0233 0 61 4.1e-005 1 R.FLEQQNQVLETK.W 26520 26522

80. P67936|TPM4_HUMAN Mass: 28619 Score: 220 Queries matched: 23 emPAI: 1.70 Tropomyosin alpha-4 chain OS=Homo sapiens GN=TPM4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7457 408.7551 815.4957 815.5116 -0.0160 1 15 2.5 3 K.LLSDKLK.E 7456 7461 12383 447.7362 893.4578 893.4606 -0.0029 1 34 0.024 1 R.KYEEVAR.K 12382 12385 15012 481.7348 961.4551 961.4604 -0.0053 0 35 0.021 1 K.TIDDLEEK.L 15011 5048 501.2742 1000.5339 1000.5553 -0.0214 0 5 70 8 M.AGLNSLEAVK.R 15917 16308 508.2678 1014.5211 1014.5094 0.0117 0 29 0.077 1 K.AEGDVAALNR.R 22810 622.3190 1242.6235 1242.6456 -0.0220 0 61 3.9e-005 1 R.IQLVEEELDR.A 22813 22814 22816 22818 23450 636.8265 1271.6384 1271.6469 -0.0085 1 69 5.8e-006 1 R.EKAEGDVAALNR.R 23451 23980 649.8179 1297.6212 1297.7605 -0.1393 1 14 2 2 R.KLVILEGELER.A 24908 447.8911 1340.6516 1340.6459 0.0057 1 11 4.3 2 K.SLEAASEKYSEK.E 26508 492.8953 1475.6641 1475.6739 -0.0098 1 30 0.043 1 K.LEEAEKAADESER.G 26511 27623 581.6266 1741.8579 1741.8595 -0.0016 1 77 6.6e-007 1 R.KIQALQQQADEAEDR.A

81. P62988|UBIQ_HUMAN Mass: 8560 Score: 217 Queries matched: 30 emPAI: 9.43 Ubiquitin OS=Homo sapiens GN=RPS27A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17059 520.2707 1038.5269 1038.5094 0.0175 0 23 0.27 1 K.EGIPPDQQR.L 17050 17051 17052 17053 17054 17060 18130 534.3004 1066.5862 1066.6135 -0.0272 0 54 0.00018 1 K.ESTLHLVLR.L 18127 5796 18607 541.2702 1080.5258 1080.5451 -0.0193 0 62 3.3e-005 1 R.TLSDYNIQK.E 18599 18600 18604 18606 18608 18609 26794 762.3723 1522.7300 1522.7740 -0.0439 1 44 0.0015 1 K.IQDKEGIPPDQQR.L 26793 26795 26796 26797 26799 26800 26801 2 27729 894.4434 1786.8722 1786.9200 -0.0478 0 80 4e-007 1 K.TITLEVEPSDTIENVK.A

82. P36222|CH3L1_HUMAN Mass: 42998 Score: 216 Queries matched: 16 emPAI: 0.40 Chitinase-3-like protein 1 OS=Homo sapiens GN=CHI3L1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6196 561.2613 560.2541 560.2806 -0.0265 0 0 1.9e+002 7 K.DALAAT.- 7428 408.2431 814.4716 814.4701 0.0015 0 26 0.15 1 K.SVPPFLR.T 7425 7427 10321 433.2585 864.5024 864.5069 -0.0045 1 7 11 2 K.SKVQYLK.D 11794 438.7342 875.4539 875.4461 0.0078 0 5 20 5 K.IASNTQSR.R 11795 12873 452.2648 902.5151 902.5225 -0.0074 0 30 0.071 1 R.FPLTNAIK.D 12876 21944 403.8789 1208.6148 1208.6051 0.0097 0 15 1.4 1 R.GTTGHHSPLFR.G 21966 606.3013 1210.5881 1210.6081 -0.0200 0 74 2e-006 1 K.VTIDSSYDIAK.I 21968 22203 609.3391 1216.6637 1216.6816 -0.0178 0 77 1.1e-006 1 R.ILGQQVPYATK.G 22204 22205 26216 719.7934 1437.5722 1437.5831 -0.0109 0 45 0.0011 1 R.EGDGSCFPDALDR.F

83. Q9UL46|PSME2_HUMAN Mass: 27515 Score: 214 Queries matched: 13 emPAI: 0.91 Proteasome activator complex subunit 2 OS=Homo sapiens GN=PSME2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7482 409.2328 816.4511 816.4527 -0.0017 0 43 0.0032 1 R.AMVLDLR.A 7480 7485 8154 417.2333 832.4520 832.4477 0.0043 0 (34) 0.029 1 R.AM VLDLR.A 9649 423.7629 845.5113 845.4607 0.0506 1 7 15 2 R.GDAVAKASK.E 13013 453.2629 904.5112 904.5130 -0.0018 1 35 0.021 1 R.KQVEVFR.Q 12943 12956 13019 19844 562.3008 1122.5871 1122.5921 -0.0050 0 55 0.00016 1 K.VEAFQTTISK.Y 25407 684.2806 1366.5466 1366.5558 -0.0092 1 6 8.4 3 K.DDEMETDKQEK.K 26872 767.8681 1533.7217 1533.7311 -0.0094 0 85 1.4e-007 1 K.IEDGNDFGVAIQEK.V 26871

84. P78417|GSTO1_HUMAN Mass: 27833 Score: 214 Queries matched: 27 emPAI: 0.89 Glutathione S-transferase omega-1 OS=Homo sapiens GN=GSTO1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13807 463.7049 925.3952 925.4116 -0.0164 0 27 0.097 1 R.FCPFAER.T 13808 13809 13810 13811 13812 14464 473.2620 944.5095 944.5178 -0.0083 0 26 0.17 1 K.LEEVLTNK.K 14460 18332 537.3039 1072.5932 1072.6128 -0.0196 1 29 0.078 1 K.LEEVLTNKK.T 18333 5895 540.3079 1078.6013 1078.6135 -0.0122 0 41 0.011 1 R.HEVININLK.N 18527 18792 545.2664 1088.5182 1088.5390 -0.0208 0 48 0.00081 1 K.LLPDDPYEK.A 18788 18789 18793 18795 18797 18798 22039 606.7804 1211.5462 1211.5605 -0.0142 0 30 0.041 1 K.LNECVDHTPK.L 22041 24512 660.8326 1319.6506 1319.6834 -0.0328 0 61 3.7e-005 1 K.GSAPPGPVPEGSIR.I 24515 24516 24517 24518 24519

85. Q01469|FABP5_HUMAN Mass: 15497 Score: 213 Queries matched: 11 emPAI: 2.06

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Fatty acid-binding protein, epidermal OS=Homo sapiens GN=FABP5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12926 453.1893 904.3641 904.3637 0.0004 0 27 0.13 1 K.GFDEYM K.E 13877 464.2825 926.5504 926.5549 -0.0045 0 60 5.3e-005 1 K.ELGVGIALR.K 3840 13859 3841 15932 501.2704 1000.5263 1000.5302 -0.0039 0 3 34 5 M.ATVQQLEGR.W 16604 513.2326 1024.4506 1024.4462 0.0045 0 46 0.0013 1 K.FEETTADGR.K 16594 20659 577.2716 1152.5287 1152.5411 -0.0124 1 50 0.00054 1 K.FEETTADGRK.T 23437 636.2950 1270.5755 1270.5864 -0.0109 0 85 1.5e-007 1 K.TTQFSCTLGEK.F 23436

86. Q09666|AHNK_HUMAN Mass: 629213 Score: 211 Queries matched: 116 emPAI: 0.02 Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens GN=AHNAK PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5428 518.3100 517.3027 517.3224 -0.0196 1 0 1.7e+002 2 K.VKGSK.F 6154 558.1771 557.1699 557.3537 -0.1838 1 2 53 4 K.SPKVK.G 9552 422.2302 842.4459 842.4498 -0.0039 0 35 0.021 1 K.ADLGVSGPK.V 9864 426.7536 851.4926 851.4290 0.0636 0 0 46 2 R.GPDWHLK.M 10357 433.7592 865.5038 865.4732 0.0306 1 2 40 4 K.VTFPKMK.I 11550 436.2504 870.4862 870.4811 0.0052 0 3 34 5 K.ADVVVSGPK.V 2582 437.2221 872.4296 872.4603 -0.0307 0 9 21 3 K.GDISISGPK.V 12167 444.2208 886.4270 886.4396 -0.0126 0 32 0.041 1 K.ADVDVSGPK.M 2905 12190 2906 444.2261 886.4376 886.4396 -0.0021 0 8 39 2 K.GDADVSVPK.L 12173 12175 12250 444.7445 887.4744 887.5076 -0.0332 1 5 19 9 K.LNIEGKSK.K 12260 12675 451.2273 900.4401 900.4553 -0.0152 0 59 8.8e-005 1 K.ADIDVSGPK.V 12665 12670 12671 12672 12677 12680 12682 3295 12683 451.2333 900.4521 900.4553 -0.0031 0 36 0.016 1 K.ADVDISGPK.I 12667 12673 12674 12689 12732 3599 457.2482 912.4818 912.5280 -0.0463 0 6 30 4 K.GDVVVSLPK.V 3593 13339 13363 3621 13380 457.2690 912.5234 912.5029 0.0205 0 3 28 3 K.GGVDVTLPR.V 3631 13461 458.2547 914.4948 914.4709 0.0239 0 9 8.8 1 K.GDVDVSVPK.V 13442 13460 13913 465.2495 928.4843 928.4866 -0.0022 0 23 0.33 1 K.GDVDVSLPK.L 13910 14201 469.2436 936.4726 936.3834 0.0893 0 2 34 6 K.MPDMHFK.A 14845 479.2645 956.5144 956.5179 -0.0035 0 12 3.6 8 K.LEGPDVSLK.G 15147 485.7656 969.5167 969.5495 -0.0328 1 2 29 8 K.LEGELKGPK.V 15719 496.2586 990.5025 990.4692 0.0334 0 6 13 10 K.GDMDISLPK.V 15760 497.2308 992.4471 992.4815 -0.0343 0 2 33 5 K.GDYDVTVPK.V 15917 501.2444 1000.4742 1000.5302 -0.0560 0 4 24 6 K.VGGSGVNVNAK.G 15921 15930 501.2612 1000.5079 1000.5706 -0.0626 1 3 27 4 K.APKIGFSGPK.L 16006 501.7853 1001.5560 1001.5580 -0.0019 0 7 12 4 K.LQVTMPGIK.V 16005 16009 5072 16270 507.7346 1013.4546 1013.5393 -0.0847 0 4 24 3 K.VQTPEVDVK.G 17627 528.2682 1054.5219 1054.4641 0.0578 0 4 19 4 K.GEYDVTMPK.V 17661 528.7727 1055.5308 1055.5611 -0.0303 0 27 0.12 1 K.VSAPGVQGDVK.G 18128 534.2919 1066.5692 1066.5771 -0.0079 1 15 1.7 1 K.GPEVDLKGPR.L 18126 18129 19221 552.3072 1102.5999 1102.5878 0.0121 1 8 11 3 K.LKMPEMNIK.A 19450 555.2388 1108.4630 1108.5951 -0.1320 1 6 12 10 K.MPKFSVSGLK.A 19610 558.7790 1115.5435 1115.5533 -0.0098 0 8 8.2 2 K.MPDVDISVPK.I 19662 560.2811 1118.5476 1118.6812 -0.1336 1 2 37 5 R.IYTTKIKPR.L 19992 564.7545 1127.4944 1127.6186 -0.1243 1 24 0.26 2 K.IKGDVDVSAPK.L 19988 19989 19990 19991 19993 19994 19995 19 20041 566.2496 1130.4846 1130.5827 -0.0981 1 16 1.4 2 K.MPEMSIKAPK.I 6328 570.2247 1138.4349 1138.5515 -0.1166 1 4 42 7 K.FKMPDMNIK.A 20940 583.2996 1164.5847 1164.6035 -0.0188 1 6 12 6 K.MPKFSMPSLK.G 21269 591.8014 1181.5882 1181.5160 0.0722 0 10 4.2 6 R.LSSSSSNDSGNK.V 21267 6551 592.7939 1183.5732 1183.6601 -0.0869 1 1 42 1 K.FKAEAPLPSPK.L 21952 605.7957 1209.5768 1209.6241 -0.0473 0 9 5.5 2 K.AEGPDVAVDLPK.G 23146 631.3247 1260.6349 1260.6272 0.0078 0 17 1 2 K.MSLPDVDLDLK.G 23145 1108 23379 634.3172 1266.6198 1266.6456 -0.0257 0 52 0.0003 1 K.AEGPEVDVNLPK.A 23378 23380 23556 640.8260 1279.6375 1279.6231 0.0144 0 7 9.5 8 K.GEGPDVHMTLPK.G 23550 26102 713.3361 1424.6577 1424.6491 0.0086 1 6 11 2 K.SRLSSSSSNDSGNK.V 26098 26101 26104 26106 26881 515.2640 1542.7701 1542.7963 -0.0263 1 7 8.5 3 K.MSLPDVDLDLKGPK.M 27601 870.3666 1738.7187 1738.8236 -0.1050 1 3 13 2 K.FSMPGFKGEGPEVDVK.L 27600 28526 428.8700 2139.3138 2139.1147 0.1992 1 3 3.2 1 K.MKLPQFGISTPGSDLHVNAK.G 29079 421.0890 2520.4901 2520.2959 0.1942 1 3 4.1 1 K.ADVVVSGPKVDVEVPDVSLEGPEGK.L

87. P32119|PRDX2_HUMAN Mass: 22049 Score: 209 Queries matched: 13 emPAI: 0.61 Peroxiredoxin-2 OS=Homo sapiens GN=PRDX2 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10244 431.6964 861.3782 861.4960 -0.1178 0 2 48 7 R.GLFIIDGK.G 13775 462.7165 923.4185 923.4348 -0.0164 0 46 0.0012 1 K.TDEGIAYR.G 13777 15178 486.7697 971.5249 971.5440 -0.0191 0 25 0.21 1 R.IGKPAPDFK.A 15418 489.7607 977.5068 977.5182 -0.0114 0 53 0.00029 1 K.ATAVVDGAFK.E 16551 512.2391 1022.4635 1022.5284 -0.0649 0 1 45 4 R.LSEDYGVLK.T 21973 606.3351 1210.6557 1210.6670 -0.0113 0 49 0.00059 1 R.QITVNDLPVGR.S 21969 21970 21971 21972 6666 23718 429.8955 1286.6648 1286.7711 -0.1063 1 3 22 8 R.GLFIIDGKGVLR.Q

88. P62805|H4_HUMAN Mass: 11360 Score: 205 Queries matched: 20 emPAI: 2.34 Histone H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15688 495.2797 988.5448 988.5706 -0.0257 0 43 0.0028 1 K.VFLENVIR.D 15677 15686 4933 15687 15689 20202 567.7713 1133.5281 1133.5353 -0.0072 0 32 0.035 1 R.DAVTYTEHAK.R 20195 20199 21221 590.8016 1179.5886 1179.6135 -0.0249 0 72 3.1e-006 1 R.ISGLIYEETR.G 21222 21223 21224 24582 442.5842 1324.7307 1324.7463 -0.0155 0 42 0.0027 1 R.DNIQGITKPAIR.R 24576 24577 24579 24580 24581 24583

89. P52907|CAZA1_HUMAN Mass: 33073 Score: 202 Queries matched: 13 emPAI: 0.24 F-actin-capping protein subunit alpha-1 OS=Homo sapiens GN=CAPZA1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7417 408.2300 814.4455 814.4450 0.0005 1 22 0.45 1 K.FDHLRK.E 7415 7416 10955 435.2696 868.5246 868.5243 0.0004 1 18 0.67 1 R.RQLPVTR.T 12347 446.2392 890.4639 890.4399 0.0240 1 3 30 1 R.WRSEWK.F 12343 13694 461.2530 920.4914 920.5695 -0.0781 1 11 4.6 2 K.ILSYKIGK.E 21620 599.3426 1196.6707 1196.6877 -0.0170 0 58 7.1e-005 1 R.LLLNNDNLLR.E 21619 21621 21622

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26880 771.8427 1541.6708 1541.6845 -0.0138 0 83 2.1e-007 1 K.EASDPQPEEADGGLK.S 26879

90. P00558|PGK1_HUMAN Mass: 44985 Score: 197 Queries matched: 24 emPAI: 1.22 Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7272 405.2106 808.4065 808.4079 -0.0014 0 40 0.0058 1 K.YAEAVTR.A 7271 7274 7284 12016 442.7303 883.4461 883.4439 0.0021 0 41 0.0036 1 K.ELNYFAK.A 12017 13772 462.7146 923.4146 923.4171 -0.0025 0 31 0.042 1 K.FCLDNGAK.S 14213 469.2649 936.5152 936.5029 0.0124 1 52 0.00031 1 K.KYAEAVTR.A 15053 483.2364 964.4582 964.4688 -0.0106 0 14 2.2 1 R.VDFNVPM K.N 15269 487.7334 973.4523 973.4505 0.0018 0 31 0.057 1 R.FHVEEEGK.G 16854 516.7367 1031.4589 1031.4594 -0.0005 0 36 0.017 1 K.DCVGPEVEK.A 16853 16855 16856 16857 17220 522.8147 1043.6148 1043.6227 -0.0078 1 38 0.0091 1 K.LTLDKLDVK.G 19093 549.3135 1096.6124 1096.6128 -0.0004 0 37 0.0097 1 K.VLPGVDALSNI.- 19091 19658 559.7941 1117.5736 1117.6343 -0.0607 1 5 18 2 M.SLSNKLTLDK.L 20058 566.2735 1130.5325 1130.6084 -0.0759 1 1 43 2 K.AEPAKIEAFR.A 20786 580.2863 1158.5579 1158.5669 -0.0090 1 47 0.0011 1 R.FHVEEEGKGK.D 20787 22198 609.3062 1216.5979 1216.6485 -0.0506 0 19 0.65 1 K.IQLINNM LDK.V 27273 545.5993 1633.7761 1633.7849 -0.0088 0 38 0.0057 1 K.LGDVYVNDAFGTAHR.A

91. Q5D862|FILA2_HUMAN Mass: 249296 Score: 193 Queries matched: 9 emPAI: 0.01 Filaggrin-2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8174 418.2451 834.4756 834.4963 -0.0207 0 24 0.23 2 K.ELHPVLK.N 24490 660.7701 1319.5256 1319.5630 -0.0374 0 94 1.5e-008 1 R.FSNSSSSNEFSK.C 24492 24493 24494 24499 26298 483.2741 1446.8005 1446.8446 -0.0440 1 4 19 4 K.ELLEKELHPVLK.N 26785 761.3530 1520.6914 1520.7141 -0.0227 1 4 15 4 K.QDGECGTLSKGELK.E 26869 767.3450 1532.6754 1532.6829 -0.0075 0 2 27 8 R.HGHSGHGQSTQTGSR.T

92. P02545|LMNA_HUMAN Mass: 74380 Score: 185 Queries matched: 26 emPAI: 0.21 Lamin-A/C OS=Homo sapiens GN=LMNA PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7234 404.2251 806.4357 806.4286 0.0071 1 23 0.31 2 K.VREEFK.E 860 415.7513 829.4880 829.4909 -0.0028 0 28 0.12 1 R.LQLELSK.V 861 862 9731 425.2464 848.4783 848.4756 0.0027 0 37 0.012 1 R.LAVYIDR.V 9724 9726 12705 451.2454 900.4763 900.4916 -0.0153 0 15 2.4 1 K.LEAALGEAK.K 12665 12684 3303 4686 486.7548 971.4950 971.5036 -0.0086 0 24 0.27 1 R.LSPSPTSQR.S 15174 15268 487.7303 973.4461 973.4716 -0.0255 0 9 7.4 1 K.LLEGEEER.L 16624 513.2542 1024.4938 1024.4430 0.0508 1 2 29 5 R.EMAEMRAR.M 5313 514.7911 1027.5676 1027.5662 0.0015 0 3 27 1 R.LADALQELR.A 5510 522.2707 1042.5269 1042.5407 -0.0138 0 15 5.1 1 K.EGDLIAAQAR.L 18801 545.2806 1088.5467 1088.5462 0.0005 0 78 8.7e-007 1 R.SLETENAGLR.L 18799 18800 19182 551.7651 1101.5157 1101.5666 -0.0508 1 6 13 5 R.KLLEGEEER.L 20529 574.7952 1147.5758 1147.5721 0.0038 0 51 0.00039 1 R.ITESEEVVSR.E 20526 21804 402.2150 1203.6233 1203.6030 0.0203 1 5 18 1 K.QLQDEMLRR.V 25305 680.3505 1358.6865 1358.6790 0.0075 0 63 2.2e-005 1 R.SGAQASSTPLSPTR.I 26983 783.8597 1565.7049 1565.7434 -0.0385 0 7 7.3 4 R.SVGGSGGGSFGDNLVTR.S

93. P04080|CYTB_HUMAN Mass: 11190 Score: 185 Queries matched: 12 emPAI: 0.84 Cystatin-B OS=Homo sapiens GN=CSTB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13767 462.6994 923.3843 923.4025 -0.0182 0 36 0.011 1 K.HDELTYF.- 13766 13768 3786 19836 562.2648 1122.5150 1122.5346 -0.0196 1 15 1.5 1 K.AKHDELTYF.- 19830 19832 24595 663.8408 1325.6671 1325.6980 -0.0308 0 66 1.1e-005 1 K.SQVVAGTNYFIK.V 24592 24594 24596 24597

94. P07602|SAP_HUMAN Mass: 59899 Score: 185 Queries matched: 11 emPAI: 0.20 Proactivator polypeptide OS=Homo sapiens GN=PSAP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8171 418.2265 834.4385 834.4599 -0.0215 0 31 0.051 1 K.LVGYLDR.N 8172 8173 16280 507.7473 1013.4801 1013.5757 -0.0956 0 7 12 3 K.QEILAALEK.G 18460 539.2426 1076.4707 1076.4995 -0.0288 0 62 3.7e-005 1 R.LGPGMADICK.N 18461 18462 24357 656.2880 1310.5615 1310.5965 -0.0350 0 60 3.9e-005 1 K.GCSFLPDPYQK.Q 24359 24361 31313 453.7736 2716.5982 2716.5349 0.0632 1 0 5.5 1 M.YALFLLASLLGAALAGPVLGLKECTR.G

95. P15121|ALDR_HUMAN Mass: 36230 Score: 183 Queries matched: 14 emPAI: 0.49 Aldose reductase OS=Homo sapiens GN=AKR1B1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12359 446.7435 891.4724 891.4814 -0.0090 0 26 0.17 1 K.VAIDVGYR.H 12361 12740 451.2705 900.5264 900.5393 -0.0128 0 73 3.6e-006 1 K.TTAQVLIR.F 12743 12744 12746 12747 12748 17057 520.2655 1038.5165 1038.5168 -0.0003 0 24 0.19 1 K.LIQYCQSK.G 17056 17058 19536 556.7992 1111.5839 1111.5873 -0.0034 0 35 0.015 1 K.SPPGQVTEAVK.V 19592 558.2858 1114.5571 1114.6209 -0.0638 0 9 6.5 6 K.MPILGLGTWK.S 19581

96. P09493|TPM1_HUMAN Mass: 32746 Score: 182 Queries matched: 48 emPAI: 0.72 Tropomyosin alpha-1 chain OS=Homo sapiens GN=TPM1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12383 447.7362 893.4578 893.4606 -0.0029 1 34 0.024 1 R.KYEEVAR.K 12382 12385 13636 460.2439 918.4733 918.4957 -0.0223 1 5 19 3 R.GMKVIESR.A 15664 495.2593 988.5039 988.4825 0.0215 1 13 3 5 R.AEQAEADKK.A 16136 503.7641 1005.5137 1005.5351 -0.0214 1 6 14 7 K.MQMLKLDK.E 6279 566.3074 1130.6002 1130.6005 -0.0003 0 21 1 1 K.MEIQEIQLK.E 20059 21329 593.8351 1185.6556 1185.6605 -0.0049 0 9 7.3 2 K.LVIIESDLER.A 21326 21327 21328 22810 622.3190 1242.6235 1242.6456 -0.0220 0 61 3.9e-005 1 R.IQLVEEELDR.A 22813 22814 22816 22818 24698 666.8058 1331.5970 1331.6317 -0.0347 0 99 6.7e-009 1 K.ATDAEADVASLNR.R 24703 26490 738.3901 1474.7656 1474.7701 -0.0045 1 24 0.17 2 K.MEIQEIQLKEAK.H 26462 26466 26468 26469 26471 26472 26473 2

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26508 492.8953 1475.6641 1475.6739 -0.0098 1 30 0.043 1 K.LEEAEKAADESER.G 26511 26588 496.9134 1487.7185 1487.7328 -0.0143 1 26 0.12 1 K.ATDAEADVASLNRR.I

97. P07951|TPM2_HUMAN Mass: 32945 Score: 182 Queries matched: 18 emPAI: 0.72 Tropomyosin beta chain OS=Homo sapiens GN=TPM2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7074 401.2410 800.4674 800.4756 -0.0082 0 16 1.8 1 K.IVTNNLK.S 12383 447.7362 893.4578 893.4606 -0.0029 1 34 0.024 1 R.KYEEVAR.K 12382 12385 15664 495.2593 988.5039 988.4825 0.0215 1 13 3 5 R.AEQAEADKK.Q 16136 503.7641 1005.5137 1005.5351 -0.0214 1 6 14 7 K.MQMLKLDK.E 19371 554.2602 1106.5059 1106.5720 -0.0661 1 8 9.8 3 R.AEFAERSVAK.L 22810 622.3190 1242.6235 1242.6456 -0.0220 0 61 3.9e-005 1 R.IQLVEEELDR.A 22813 22814 22816 22818 23980 649.8179 1297.6212 1297.7605 -0.1393 1 14 2 2 R.KLVILEGELER.S 24698 666.8058 1331.5970 1331.6317 -0.0347 0 99 6.7e-009 1 K.ATDAEADVASLNR.R 24703 26508 492.8953 1475.6641 1475.6739 -0.0098 1 30 0.043 1 K.LEEAEKAADESER.G 26511 26588 496.9134 1487.7185 1487.7328 -0.0143 1 26 0.12 1 K.ATDAEADVASLNRR.I

98. O75368|SH3L1_HUMAN Mass: 12766 Score: 181 Queries matched: 6 emPAI: 1.94 SH3 domain-binding glutamic acid-rich-like protein OS=Homo sapiens GN=SH3BGRL PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20785 580.2835 1158.5525 1158.5629 -0.0103 1 21 0.42 1 K.DIAANEENRK.W 21366 595.7508 1189.4870 1189.5040 -0.0170 0 58 7.1e-005 1 R.GDYDAFFEAR.E 23623 642.3409 1282.6672 1282.6769 -0.0097 0 89 5.2e-008 1 R.VYIASSSGSTAIK.K 23621 23622 25965 706.3767 1410.7389 1410.7718 -0.0330 1 40 0.004 1 R.VYIASSSGSTAIKK.K

99. Q14019|COTL1_HUMAN Mass: 16049 Score: 181 Queries matched: 22 emPAI: 1.95 Coactosin-like protein OS=Homo sapiens GN=COTL1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7166 403.7252 805.4358 805.4446 -0.0088 0 54 0.00024 1 R.AAYNLVR.D 99 7150 7169 10318 433.2196 864.4245 864.4341 -0.0096 0 8 8.4 1 K.EFVISDR.K 10319 14124 467.7463 933.4781 933.4920 -0.0138 0 53 0.00034 1 K.EVVQNFAK.E 14118 14119 14120 14121 14123 14125 4464 479.2700 956.5254 956.4273 0.0980 0 4 53 1 R.FTTGDAMSK.R 15019 481.7780 961.5415 961.5444 -0.0029 1 19 0.82 1 K.TGTDKTLVK.E 15789 497.2611 992.5076 992.5291 -0.0214 1 35 0.019 1 K.EFVISDRK.E 15790 15791 16543 511.7536 1021.4927 1021.4968 -0.0040 0 50 0.00056 1 K.ELEEDFIK.S 16539 16541 20555 575.7979 1149.5813 1149.5917 -0.0104 1 32 0.031 1 R.KELEEDFIK.S

100. P29401|TKT_HUMAN Mass: 68519 Score: 181 Queries matched: 26 emPAI: 0.45 Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6636 602.2845 601.2773 601.2820 -0.0047 0 15 6.6 2 K.SQDPR.N 7562 411.2290 820.4434 820.4443 -0.0009 0 18 0.86 1 K.AYGQALAK.L 9552 422.2302 842.4459 842.4610 -0.0151 0 6 16 5 R.DAIAQAVR.G 13474 458.2833 914.5519 914.5549 -0.0029 1 52 0.00037 1 R.KLILDSAR.A 13429 13433 13440 13471 13473 13501 458.7560 915.4975 915.5025 -0.0050 0 50 0.00067 1 K.AVELAANTK.G 13478 13496 13504 14463 473.2617 944.5088 944.5179 -0.0090 0 32 0.046 1 R.IIALDGDTK.N 14471 14592 475.2701 948.5256 948.5392 -0.0137 1 34 0.022 1 R.KAYGQALAK.L 14590 15421 489.7861 977.5577 977.5658 -0.0081 0 43 0.0027 1 K.HQPTAIIAK.T 15420 15422 18727 544.2993 1086.5841 1086.6397 -0.0556 1 6 15 10 K.LILDSARATK.G 20023 565.3209 1128.6272 1128.6251 0.0022 1 43 0.0025 1 K.LQALKDTANR.L 23237 422.2226 1263.6458 1263.6459 -0.0001 0 14 2 1 K.ISSDLDGHPVPK.Q 1791 432.2380 1293.6921 1293.7768 -0.0848 1 1 2.9e+002 2 R.VPRSGKPAELLK.M 23853 25745 464.9207 1391.7403 1391.7409 -0.0006 1 31 0.033 1 R.KISSDLDGHPVPK.Q

101. P99999|CYC_HUMAN Mass: 11855 Score: 180 Queries matched: 12 emPAI: 2.17 Cytochrome c OS=Homo sapiens GN=CYCS PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7175 403.7374 805.4603 805.4698 -0.0094 1 26 0.18 1 K.KYIPGTK.M 7176 7242 404.2404 806.4662 806.4724 -0.0062 0 28 0.087 1 K.MIFVGIK.K 7687 412.2342 822.4538 822.4673 -0.0135 0 (12) 3.2 1 K.MIFVGIK.K 7689 13134 453.7636 905.5126 905.5222 -0.0096 0 35 0.021 1 R.ADLIAYLK.K 13086 3477 26140 714.8216 1427.6287 1427.6681 -0.0394 0 68 6.8e-006 1 K.TGQAPGYSYTAANK.N 26141 26945 519.5872 1555.7397 1555.7630 -0.0233 1 56 9.9e-005 1 R.KTGQAPGYSYTAANK.N 26946

102. P25774|CATS_HUMAN Mass: 38099 Score: 178 Queries matched: 12 emPAI: 0.33 Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14789 478.7543 955.4940 955.5087 -0.0147 0 45 0.0019 1 K.GPVSVGVDAR.H 14787 14788 14790 14793 14794 14795 15867 499.7427 997.4708 997.4869 -0.0160 0 30 0.052 1 K.YTELPYGR.E 15868 15869 22157 608.2697 1214.5248 1214.5455 -0.0207 0 78 9.4e-007 1 K.GIDSDASYPYK.A 5670 528.2564 1581.7473 1581.8038 -0.0565 1 1 91 1 K.YTELPYGREDVLK.E

103. P08865|RSSA_HUMAN Mass: 32947 Score: 177 Queries matched: 16 emPAI: 0.24 40S ribosomal protein SA OS=Homo sapiens GN=RPSA PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13312 456.7757 911.5369 911.5440 -0.0071 0 37 0.008 1 R.LLVVTDPR.A 13302 13305 3583 13311 13313 3584 13314 13315 15560 493.7670 985.5194 985.5669 -0.0475 1 3 32 10 R.NTGQRAVLK.F 17859 531.2685 1060.5225 1060.5587 -0.0361 0 10 6.2 1 M.SGALDVLQMK.E 21789 602.3181 1202.6216 1202.6408 -0.0191 0 72 3.4e-006 1 K.FAAATGATPIAGR.F 21790 21791 21792 21794

104. P02786|TFR1_HUMAN Mass: 85274 Score: 176 Queries matched: 15 emPAI: 0.29 Transferrin receptor protein 1 OS=Homo sapiens GN=TFRC PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7145 403.6964 805.3782 805.3719 0.0063 0 16 1.6 1 K.DGFQPSR.S

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7243 404.7002 807.3858 807.3875 -0.0017 0 12 3.3 1 R.DLNQYR.A 11663 437.2652 872.5158 872.5331 -0.0173 0 4 31 5 K.LTVSNVLK.E 13349 457.2535 912.4925 912.5505 -0.0580 1 9 7.1 1 K.ANVTKPKR.C 13891 465.1854 928.3562 928.4978 -0.1416 0 8 7.8 1 R.LAGTESPVR.E 14187 468.7567 935.4989 935.5076 -0.0087 0 23 0.27 1 K.AVLGTSNFK.V 14182 14914 479.7973 957.5800 957.5859 -0.0059 0 28 0.098 1 K.SGVGTALLLK.L 4880 493.7668 985.5191 985.5345 -0.0154 0 17 1.2 1 K.LVHANFGTK.K 19049 548.2610 1094.5075 1094.5244 -0.0169 0 35 0.015 1 R.LTTDFGNAEK.T 21614 599.2981 1196.5817 1196.5925 -0.0108 0 45 0.0016 1 K.LDSTDFTGTIK.L 21803 602.8187 1203.6228 1203.6248 -0.0019 0 68 8.8e-006 1 K.LLNENSYVPR.E 22195 609.2724 1216.5302 1216.5360 -0.0058 0 32 0.029 1 R.EEPGEDFPAAR.R 23749 644.8324 1287.6503 1287.6670 -0.0168 0 103 2.6e-009 1 K.DSAQNSVIIVDK.N 26417 734.9025 1467.7905 1467.8045 -0.0141 0 26 0.092 1 R.SSGLPNIPVQTISR.A

105. P05109|S10A8_HUMAN Mass: 10885 Score: 173 Queries matched: 15 emPAI: 3.78 Protein S100-A8 OS=Homo sapiens GN=S100A8 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 410 411.7019 821.3892 821.4072 -0.0180 0 29 0.075 1 K.GADVWFK.E 7582 7587 11862 440.2231 878.4317 878.4419 -0.0102 0 21 0.46 1 -.M LTELEK.A 14605 475.7446 949.4747 949.5022 -0.0274 1 36 0.016 1 K.KGADVWFK.E 15020 482.2336 962.4527 962.4722 -0.0195 0 56 0.00016 1 K.GNFHAVYR.D 15021 23453 424.8962 1271.6668 1271.6874 -0.0206 0 26 0.12 1 K.ALNSIIDVYHK.Y 23452 26057 711.3473 1420.6800 1420.7020 -0.0221 0 67 7.7e-006 1 K.LLETECPQYIR.K 26054 26060 26191 478.8973 1433.6700 1433.7052 -0.0352 1 14 1.8 1 K.GNFHAVYRDDLK.K 5386 517.2604 1548.7594 1548.7970 -0.0376 1 5 84 1 K.KLLETECPQYIR.K 26930 517.2650 1548.7732 1548.7970 -0.0238 1 42 0.0025 1 K.LLETECPQYIRK.K

106. P14649|MYL6B_HUMAN Mass: 22864 Score: 172 Queries matched: 7 emPAI: 0.17 Myosin light chain 6B OS=Homo sapiens GN=MYL6B PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5147 504.2500 503.2427 503.2340 0.0088 0 8 17 1 K.EGNGK.V 1509 426.2285 1275.6637 1275.6241 0.0396 1 3 63 1 K.EGNGKVMGAELR.H 25168 677.8545 1353.6944 1353.7252 -0.0308 0 72 3.1e-006 1 R.ALGQNPTNAEVLK.V 25166 25167 25169 25170

107. P61769|B2MG_HUMAN Mass: 13820 Score: 171 Queries matched: 9 emPAI: 1.71 Beta-2-microglobulin OS=Homo sapiens GN=B2M PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7451 408.7347 815.4549 815.4654 -0.0105 1 32 0.045 1 K.IVKWDR.D 7448 19802 561.8060 1121.5973 1121.6193 -0.0220 0 47 0.0012 1 R.VNHVTLSQPK.I 19800 19801 19803 20525 574.7739 1147.5332 1147.5509 -0.0178 0 50 0.00052 1 K.VEHSDLSFSK.D 20522 26763 506.9233 1517.7480 1517.7726 -0.0245 1 36 0.011 1 R.IEKVEHSDLSFSK.D

108. P10599|THIO_HUMAN Mass: 12015 Score: 170 Queries matched: 21 emPAI: 1.36 Thioredoxin OS=Homo sapiens GN=TXN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13208 454.7171 907.4197 907.4399 -0.0203 0 42 0.0031 1 K.VGEFSGANK.E 13207 13212 13213 15945 501.2790 1000.5435 1000.5441 -0.0005 0 10 5.6 1 K.LEATINELV.- 15978 20923 583.2848 1164.5551 1164.5775 -0.0224 1 66 1.3e-005 1 K.VGEFSGANKEK.L 20911 20914 24730 668.8105 1335.6064 1335.6306 -0.0242 0 59 5.5e-005 1 K.TAFQEALDAAGDK.L 24743 24746 24747 24751 24752 24753 24757 2

109. P06703|S10A6_HUMAN Mass: 10230 Score: 166 Queries matched: 23 emPAI: 0.94 Protein S100-A6 OS=Homo sapiens GN=S100A6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12326 446.2061 890.3976 890.4167 -0.0191 0 (7) 13 1 R.LMEDLDR.N 13177 454.2047 906.3948 906.4117 -0.0168 0 39 0.0075 1 R.LMEDLDR.N 13175 13176 13179 13436 458.2373 914.4601 914.4821 -0.0220 0 60 6.2e-005 1 K.LQDAEIAR.L 13429 13432 13433 13435 13437 3645 13439 13441 134 15905 500.7919 999.5692 999.5964 -0.0272 1 18 1 4 K.ELKELIQK.E 15903 15913

110. Q5VSK2|MRC1L_HUMAN Mass: 168904 Score: 164 Queries matched: 22 emPAI: 0.14 Macrophage mannose receptor 1-like protein 1 OS=Homo sapiens GN=MRC1L1 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6462 585.3138 584.3065 584.3533 -0.0469 0 6 30 3 R.VEPLK.S 9843 426.7248 851.4351 851.3443 0.0908 0 3 26 10 K.ETMDNAR.A 10180 430.2108 858.4070 858.3905 0.0165 0 10 7 1 K.SSYSLMR.Q 11653 437.2468 872.4791 872.4790 0.0002 0 15 2.2 1 K.LCLGVPSK.T 11934 441.2569 880.4993 880.4840 0.0152 1 2 32 10 K.LGYICKK.G 11955 441.7321 881.4497 881.3668 0.0829 0 9 6.2 8 K.DGYWADR.G 11953 12498 449.2205 896.4264 896.4174 0.0090 0 21 0.38 1 R.GYICQTR.S 12495 14023 466.2664 930.5182 930.4671 0.0510 1 7 14 7 R.KNWQEAR.K 15001 481.2451 960.4757 960.4699 0.0058 0 31 0.053 1 K.SCVSLNPGK.N 14998 17602 527.2695 1052.5245 1052.5185 0.0059 1 19 0.7 1 K.RGYICQTR.S 18446 538.7936 1075.5726 1075.5662 0.0064 0 48 0.00094 1 R.LITASGSYHK.L 18445 19545 557.2523 1112.4901 1112.4815 0.0086 0 22 0.28 1 K.DYQYYFSK.E 6488 587.2748 1172.5350 1172.5172 0.0178 0 10 19 1 K.IFGFMEEER.K 21545 598.7541 1195.4936 1195.5509 -0.0573 0 3 25 2 K.FEGSESLWNK.D 22102 607.8122 1213.6099 1213.6190 -0.0091 0 73 2.3e-006 1 R.SQGPEIVEVEK.G 23991 650.3049 1298.5952 1298.5925 0.0027 0 70 4.2e-006 1 K.IYGTTDNLCSR.G 23988 24687 666.3058 1330.5970 1330.5942 0.0028 0 32 0.033 1 K.GEDLFFNYGNR.Q

Proteins matching the same set of peptides: P22897|MRC1_HUMAN Mass: 168870 Score: 164 Queries matched: 22 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1

111. P14550|AK1A1_HUMAN Mass: 36892 Score: 163 Queries matched: 12 emPAI: 0.47 Alcohol dehydrogenase [NADP+] OS=Homo sapiens GN=AKR1A1 PE=1 SV=3

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7396 407.7534 813.4922 813.4960 -0.0037 0 36 0.015 1 K.ALEALVAK.G 7398 7399 12523 449.2765 896.5385 896.5443 -0.0059 0 59 5.6e-005 1 R.SPAQILLR.W 12520 12521 12522 3204 14689 476.7531 951.4916 951.4913 0.0003 0 37 0.011 1 R.EELFVTSK.L 19592 558.2858 1114.5571 1114.6209 -0.0638 0 9 6.5 6 K.MPLIGLGTWK.S 25229 453.5665 1357.6777 1357.7605 -0.0828 1 10 4.5 1 K.ETWKALEALVAK.G 26940 776.3749 1550.7352 1550.7576 -0.0225 0 52 0.00026 1 R.GLEVTAYSPLGSSDR.A

112. P29373|RABP2_HUMAN Mass: 15854 Score: 160 Queries matched: 15 emPAI: 1.99 Cellular retinoic acid-binding protein 2 OS=Homo sapiens GN=CRABP2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8601 421.2565 840.4984 840.5069 -0.0084 1 32 0.034 1 K.LLKGEGPK.T 1077 8612 9843 426.7248 851.4351 851.4389 -0.0037 0 40 0.0053 1 R.TTEINFK.V 1528 9840 9841 19156 550.7538 1099.4930 1099.5186 -0.0256 0 29 0.08 1 K.QEGDTFYIK.T 19158 19430 554.7744 1107.5343 1107.5448 -0.0104 0 52 0.00033 1 R.SENFEELLK.V 19427 19428 19429 27874 627.2831 1878.8274 1878.8418 -0.0144 0 48 0.00049 1 K.VGEEFEEQTVDGRPCK.S 27875

113. Q04917|1433F_HUMAN Mass: 28372 Score: 160 Queries matched: 37 emPAI: 0.87 14-3-3 protein eta OS=Homo sapiens GN=YWHAH PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7449 408.7337 815.4527 815.4137 0.0391 0 12 4.9 3 R.LAEQAER.Y 7448 7598 412.2046 822.3946 822.4123 -0.0177 0 27 0.11 1 K.EAFEISK.E 7607 7614 12870 452.2596 902.5046 902.5073 -0.0027 0 42 0.0039 1 R.VISSIEQK.T 12861 12863 12865 12866 12867 12868 12872 12878 12 3528 454.2523 906.4901 906.5174 -0.0274 0 56 0.0003 1 R.NLLSVAYK.N 3518 13194 3524 3529 13198 13199 13200 13201 13202 17176 522.2748 1042.5350 1042.5519 -0.0169 1 29 0.064 2 R.ARLAEQAER.Y 17172 18114 533.7635 1065.5124 1065.5342 -0.0218 0 32 0.034 1 R.YLAEVASGEK.K 18098 18116 21470 597.8227 1193.6308 1193.6292 0.0016 1 47 0.0011 1 R.YLAEVASGEKK.N 21439 22969 626.7896 1251.5646 1251.6030 -0.0384 0 10 4.8 2 K.EQMQPTHPIR.L

114. Q96C19|EFHD2_HUMAN Mass: 26794 Score: 157 Queries matched: 28 emPAI: 0.30 EF-hand domain-containing protein D2 OS=Homo sapiens GN=EFHD2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9674 424.7033 847.3920 847.4287 -0.0367 0 4 25 2 M.ATDELATK.L 9676 9845 426.7283 851.4419 851.4389 0.0031 0 9 6.9 3 K.ELQSTFK.- 15241 487.2745 972.5343 972.5352 -0.0009 0 25 0.2 1 K.VQAINVSSR.F 23187 631.8074 1261.6001 1261.6402 -0.0400 0 71 3.6e-006 1 R.LSEIDVSSEGVK.G 23150 23153 23154 23155 23156 23158 23161 23 27546 575.6271 1723.8593 1723.8601 -0.0008 1 11 3.4 1 R.RADLNQGIGEPQSPSR.R

115. P62826|RAN_HUMAN Mass: 24579 Score: 153 Queries matched: 16 emPAI: 0.54 GTP-binding nuclear protein Ran OS=Homo sapiens GN=RAN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2880 443.7445 885.4745 885.5185 -0.0439 1 4 27 5 K.SIVFHRK.K 14960 480.7357 959.4568 959.4712 -0.0144 0 29 0.086 1 R.HLTGEFEK.K 14956 14959 16314 508.2810 1014.5475 1014.5710 -0.0235 0 56 0.00016 1 K.LVLVGDGGTGK.T 16305 16311 16315 16316 16317 16318 16320 19611 558.7816 1115.5486 1115.5723 -0.0238 1 1 44 6 K.RHLTGEFEK.K 22100 607.7947 1213.5748 1213.5979 -0.0231 0 45 0.0017 1 K.NLQYYDISAK.S 22098 22101

116. P26447|S10A4_HUMAN Mass: 11949 Score: 151 Queries matched: 22 emPAI: 6.39 Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8075 416.2402 830.4658 830.4861 -0.0203 1 31 0.055 1 K.LNKSELK.E 12316 445.7461 889.4775 889.4909 -0.0134 0 32 0.038 1 R.ELPSFLGK.R 2987 12311 12312 12313 12315 2989 13228 455.2136 908.4126 908.4239 -0.0113 0 43 0.0028 1 R.TDEAAFQK.L 13223 13231 13243 17474 523.7911 1045.5676 1045.5920 -0.0244 1 31 0.055 1 R.ELPSFLGKR.T 18003 533.2416 1064.4686 1064.4920 -0.0234 0 37 0.0091 1 K.LMSNLDSNR.D 18050 533.2603 1064.5060 1064.5251 -0.0191 1 47 0.0011 1 K.RTDEAAFQK.L 18010 18016 18022 18031 18044 18048 18778 544.8061 1087.5977 1087.6237 -0.0260 1 51 0.00043 1 K.SELKELLTR.E

117. P25788|PSA3_HUMAN Mass: 28643 Score: 150 Queries matched: 8 emPAI: 0.13 Proteasome subunit alpha type-3 OS=Homo sapiens GN=PSMA3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13624 460.2350 918.4555 918.5035 -0.0481 1 9 7.1 9 K.RLFNVDR.H 13620 13625 13637 15655 495.2448 988.4749 988.4825 -0.0076 1 16 1.5 1 K.DIREEAEK.Y 6398 576.8005 1151.5864 1151.5975 -0.0111 0 21 0.37 1 R.SNFGYNIPLK.H 22200 609.3220 1216.6295 1216.6411 -0.0116 0 99 6.6e-009 1 K.AVENSSTAIGIR.C 22202

118. Q86UX7|URP2_HUMAN Mass: 76475 Score: 149 Queries matched: 20 emPAI: 0.27 Fermitin family homolog 3 OS=Homo sapiens GN=FERMT3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6122 553.2882 552.2809 552.2400 0.0410 0 (4) 22 3 -.MAGMK.T 6324 569.3756 568.3684 568.2349 0.1335 0 11 3.8 1 -.M AGMK.T 2492 436.2514 870.4882 870.4923 -0.0040 0 21 1.4 1 K.IVEQINR.K 11549 11550 11553 11558 11844 439.7392 877.4638 877.4657 -0.0019 0 34 0.023 1 K.YGILADAR.L 11841 11846 12728 451.2576 900.5007 900.4817 0.0190 0 56 0.00019 1 K.AGDALWLR.F 12701 12708 16065 502.7447 1003.4748 1003.4862 -0.0114 0 39 0.0068 1 K.ETTLSYYK.S 16746 514.7968 1027.5790 1027.5914 -0.0124 0 52 0.00031 1 R.IDLAVGDVVK.T 16748 16749 19770 561.3005 1120.5865 1120.5876 -0.0011 0 52 0.00032 1 R.LTQLYEQAR.W 19758 23415 635.3799 1268.7453 1268.7605 -0.0152 0 29 0.056 1 K.VVLAGGVAPALFR.G

119. P31949|S10AB_HUMAN Mass: 11847 Score: 145 Queries matched: 17 emPAI: 2.17 Protein S100-A11 OS=Homo sapiens GN=S100A11 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16447 510.2407 1018.4668 1018.4931 -0.0263 0 44 0.0024 1 K.ISSPTETER.C 16445 16446 16448 16449 16450 16452 16453 17762 530.7397 1059.4648 1059.4873 -0.0225 0 54 0.00026 1 K.DGYNYTLSK.T 17760 17763

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20374 571.2906 1140.5666 1140.5887 -0.0222 1 34 0.018 1 K.NQKDPGVLDR.M 20368 20376 20378 21094 589.3015 1176.5884 1176.5631 0.0253 1 2 31 8 K.DPGVLDRMMK.K 26533 493.8974 1478.6704 1478.7041 -0.0337 1 35 0.012 1 K.YAGKDGYNYTLSK.T

120. P11021|GRP78_HUMAN Mass: 72402 Score: 142 Queries matched: 16 emPAI: 0.16 78 kDa glucose-regulated protein OS=Homo sapiens GN=HSPA5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4261 476.2466 475.2393 475.2391 0.0003 0 10 19 2 K.GTGNK.N 4264 4282 7574 411.6321 821.2497 821.3589 -0.1092 0 1 31 1 R.MVNDAEK.F 7570 3897 466.2656 930.5166 930.4770 0.0396 1 3 83 5 K.NQIGDKEK.L 18358 537.7764 1073.5382 1073.5465 -0.0083 0 29 0.082 1 K.ITITNDQNR.L 19471 555.2610 1108.5074 1108.5764 -0.0690 1 8 7.5 5 K.ETAEAYLGKK.V 19472 21376 596.3160 1190.6174 1190.6295 -0.0121 0 11 4.4 1 K.VYEGERPLTK.D 104 403.8638 1208.5695 1208.5594 0.0101 1 1 41 4 K.ETMEKAVEEK.I 22410 614.8084 1227.6023 1227.6207 -0.0184 0 65 1.7e-005 1 R.VEIIANDQGNR.I 22412 22413 1846 432.8649 1295.5728 1295.5915 -0.0187 1 0 42 1 K.LSSEDKETMEK.A 26987 783.8786 1565.7427 1565.7726 -0.0298 0 63 2e-005 1 R.ITPSYVAFTPEGER.L

121. P18669|PGAM1_HUMAN Mass: 28900 Score: 142 Queries matched: 15 emPAI: 0.64 Phosphoglycerate mutase 1 OS=Homo sapiens GN=PGAM1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15319 488.2492 974.4838 974.4855 -0.0017 0 38 0.0095 1 K.AMEAVAAQGK.A 15720 496.2603 990.5061 990.4804 0.0257 0 (8) 9.1 1 K.AM EAVAAQGK.A 17753 530.2862 1058.5578 1058.5509 0.0069 0 39 0.0068 1 R.HYGGLTGLNK.A 17737 17738 17742 17744 17746 17747 17749 20587 575.8346 1149.6546 1149.6618 -0.0072 0 53 0.00025 1 R.VLIAAHGNSLR.G 20588 20601 24381 438.2119 1311.6140 1311.5956 0.0184 0 24 0.2 1 R.HGESAWNLENR.F 24379

122. P17900|SAP3_HUMAN Mass: 21281 Score: 140 Queries matched: 14 emPAI: 0.39 Ganglioside GM2 activator OS=Homo sapiens GN=GM2A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7420 408.2360 814.4575 814.4800 -0.0225 0 30 0.074 1 K.VDLVLEK.E 7412 7421 7429 316 7430 12378 447.7267 893.4388 893.4494 -0.0106 0 15 1.9 1 K.EGTYSLPK.S 12377 12393 16140 503.7672 1005.5198 1005.5342 -0.0144 0 62 3.5e-005 1 R.IESVLSSSGK.R 16136 16137 16138 16139

123. P01876|IGHA1_HUMAN Mass: 38486 Score: 139 Queries matched: 13 emPAI: 0.20 Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7492 409.6962 817.3778 817.3970 -0.0192 0 29 0.097 1 R.VAAEDWK.K 12480 448.7243 895.4341 895.4552 -0.0211 0 32 0.03 1 K.YLTWASR.Q 14021 466.2658 930.5171 930.5386 -0.0215 0 46 0.0016 1 K.TPLTATLSK.S 14002 3890 3895 14018 14019 3898 14022 14024 3899 14262 470.7353 939.4561 939.4774 -0.0212 0 8 7.5 1 K.SAVQGPPER.D

124. P52790|HXK3_HUMAN Mass: 100616 Score: 139 Queries matched: 21 emPAI: 0.16 Hexokinase-3 OS=Homo sapiens GN=HK3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14722 477.2526 952.4907 952.5090 -0.0184 0 55 0.00015 1 R.GQASPAPAVR.M 14723 14726 14727 16724 514.7498 1027.4851 1027.5047 -0.0196 0 30 0.055 1 R.NVAGVPGDSGR.M 16716 16727 17267 523.2751 1044.5356 1044.5750 -0.0394 0 5 17 4 R.GVAMVTAVAAR.L 5591 523.2898 1044.5650 1044.5676 -0.0026 1 10 14 2 K.GLRGEASSLR.M 5547 17270 17296 17319 17340 17863 531.2702 1060.5258 1060.5699 -0.0441 0 (1) 42 2 R.GVAMVTAVAAR.L 18770 544.7862 1087.5579 1087.5808 -0.0229 0 32 0.034 1 K.GAALVTAVACR.L 23359 422.8873 1265.6401 1265.6476 -0.0075 1 3 25 1 R.HVAVLDEDRGR.V 23869 432.5968 1294.7686 1294.7034 0.0652 1 1 33 2 R.STLISWTKGFR.C 26301 724.8327 1447.6508 1447.6943 -0.0435 0 77 9.3e-007 1 R.FDASVDQASINPGK.Q 6442 583.9381 1748.7926 1748.9196 -0.1270 0 3 19 10 R.GLEELAVSVGVDGTLYK.L 6443

125. P13489|RINI_HUMAN Mass: 51766 Score: 138 Queries matched: 5 emPAI: 0.23 Ribonuclease inhibitor OS=Homo sapiens GN=RNH1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8067 416.2332 830.4518 830.4498 0.0020 0 19 0.96 1 R.ELALGSNK.L 8065 15016 481.7500 961.4854 961.4903 -0.0049 0 44 0.0026 1 R.DLCGIVASK.A 20536 575.2609 1148.5073 1148.5132 -0.0059 0 55 0.00015 1 R.LDDCGLTEAR.C 26839 765.8671 1529.7197 1529.7321 -0.0125 0 91 3.1e-008 1 K.ELSLAGNELGDEGAR.L

126. P09382|LEG1_HUMAN Mass: 15048 Score: 137 Queries matched: 22 emPAI: 2.97 Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9865 426.7741 851.5337 851.4211 0.1126 1 10 5.2 3 K.IKCVAFD.- 11824 439.2540 876.4934 876.5069 -0.0135 0 29 0.076 1 K.SFVLNLGK.D 2659 11823 11825 15108 484.7268 967.4390 967.4651 -0.0261 0 39 0.0056 1 K.LPDGYEFK.F 15111 15112 17113 521.2798 1040.5450 1040.5614 -0.0165 1 44 0.0018 1 R.VRGEVAPDAK.S 17108 17110 17111 17114 17122 18426 538.7321 1075.4496 1075.4683 -0.0187 0 45 0.0018 1 K.DGGAWGTEQR.E 18427 18430 18431 18438 26579 496.2258 1485.6555 1485.6783 -0.0227 0 45 0.0013 1 K.DSNNLCLHFNPR.F 26578 27313 549.9158 1646.7255 1646.7471 -0.0216 0 31 0.031 1 R.FNAHGDANTIVCNSK.D

127. P31947|1433S_HUMAN Mass: 27871 Score: 136 Queries matched: 33 emPAI: 0.47 14-3-3 protein sigma OS=Homo sapiens GN=SFN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5094 503.0922 502.0849 502.2751 -0.1902 0 6 16 1 K.GAVEK.G 7449 408.7337 815.4527 815.4137 0.0391 0 12 4.9 3 K.LAEQAER.Y 7448 10152 429.7297 857.4448 857.5334 -0.0886 1 8 11 3 R.ASLIQKAK.L 10151 10173 12870 452.2596 902.5046 902.5073 -0.0027 0 42 0.0039 1 R.VLSSIEQK.S 12861 12863 12865 12866 12867 12868 12872 12878 12 3528 454.2523 906.4901 906.5174 -0.0274 0 56 0.0003 1 R.NLLSVAYK.N 3518 13194 3524 3529 13198 13199 13200 13201 13202 19722 561.2705 1120.5265 1120.4569 0.0696 0 5 19 5 R.YEDMAAFMK.G

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21681 599.7975 1197.5804 1197.6176 -0.0372 1 4 18 2 K.KEM PPTNPIR.L 26899 516.2359 1545.6859 1545.6907 -0.0048 1 30 0.034 1 K.SNEEGSEEKGPEVR.E

128. P06753|TPM3_HUMAN Mass: 32856 Score: 135 Queries matched: 45 emPAI: 0.54 Tropomyosin alpha-3 chain OS=Homo sapiens GN=TPM3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12383 447.7362 893.4578 893.4606 -0.0029 1 34 0.024 1 R.KYEEVAR.K 12382 12385 14334 471.7708 941.5270 941.5658 -0.0388 1 10 5.7 6 K.VIENRALK.D 14337 16136 503.7641 1005.5137 1005.5351 -0.0214 1 6 14 7 K.MQMLKLDK.E 19371 554.2602 1106.5059 1106.5720 -0.0661 1 8 9.8 3 R.AEFAERSVAK.L 6279 566.3074 1130.6002 1130.6005 -0.0003 0 21 1 1 K.MELQEIQLK.E 20059 22810 622.3190 1242.6235 1242.6456 -0.0220 0 61 3.9e-005 1 R.IQLVEEELDR.A 22813 22814 22816 22818 24450 658.8214 1315.6282 1315.6368 -0.0086 0 41 0.0044 1 K.AADAEAEVASLNR.R 24448 24449 26490 738.3901 1474.7656 1474.7701 -0.0045 1 24 0.17 2 K.MELQEIQLKEAK.H 26462 26466 26468 26469 26471 26472 26473 2 26508 492.8953 1475.6641 1475.6739 -0.0098 1 30 0.043 1 K.LEEAEKAADESER.G 26511

129. P30050|RL12_HUMAN Mass: 17979 Score: 131 Queries matched: 10 emPAI: 0.21 60S ribosomal protein L12 OS=Homo sapiens GN=RPL12 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7317 405.7408 809.4671 809.4759 -0.0088 1 4 21 9 K.ALKEPPR.D 7318 2797 441.2702 880.5258 880.5382 -0.0124 0 47 0.0024 1 K.IGPLGLSPK.K 11934 11936 2794 11938 11939 2796 11941

130. P15259|PGAM2_HUMAN Mass: 28919 Score: 130 Queries matched: 14 emPAI: 0.45 Phosphoglycerate mutase 2 OS=Homo sapiens GN=PGAM2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15319 488.2492 974.4838 974.4855 -0.0017 0 38 0.0095 1 K.AMEAVAAQGK.A 15720 496.2603 990.5061 990.4804 0.0257 0 (8) 9.1 1 K.AMEAVAAQGK.A 17753 530.2862 1058.5578 1058.5509 0.0069 0 39 0.0068 1 R.HYGGLTGLNK.A 17737 17738 17742 17744 17746 17747 17749 20587 575.8346 1149.6546 1149.6618 -0.0072 0 53 0.00025 1 R.VLIAAHGNSLR.G 20588 20601 26819 510.2335 1527.6787 1527.7392 -0.0605 1 2 23 1 R.RSFDIPPPPMDEK.H

131. P59998|ARPC4_HUMAN Mass: 19768 Score: 127 Queries matched: 13 emPAI: 1.04 Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens GN=ARPC4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14564 474.7665 947.5184 947.5328 -0.0143 0 23 0.3 1 R.IVAEEFLK.N 14565 14566 16201 505.2728 1008.5311 1008.5392 -0.0082 0 34 0.022 1 R.AENFFILR.R 16199 16203 21327 593.8300 1185.6455 1185.6717 -0.0262 0 47 0.001 1 K.VLIEGSINSVR.V 21326 21328 21329 23387 634.8596 1267.7046 1267.7500 -0.0454 0 32 0.03 1 K.ELLLQPVTISR.N 23394 31022 446.9078 2675.4033 2675.2941 0.1092 0 1 14 5 R.KPVEGYDISFLITNFHTEQM YK.H

132. P02787|TRFE_HUMAN Mass: 79280 Score: 125 Queries matched: 23 emPAI: 0.32 Serotransferrin OS=Homo sapiens GN=TF PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11670 437.7289 873.4432 873.4345 0.0088 0 34 0.032 1 K.DSAHGFLK.V 15042 482.7655 963.5164 963.5250 -0.0086 0 62 3.1e-005 1 R.APNHAVVTR.K 15848 499.2402 996.4659 996.4698 -0.0040 0 28 0.076 1 K.ASYLDCIR.A 15896 500.7510 999.4874 999.4913 -0.0038 0 20 0.61 1 K.YLGEEYVK.A 18922 546.8161 1091.6175 1091.6200 -0.0024 1 32 0.034 1 R.APNHAVVTRK.D 19917 563.2609 1124.5072 1124.6124 -0.1052 1 10 4.9 2 K.EACVHKILR.Q 19912 19914 19915 6244 19922 19923 19924 19925 23620 642.2803 1282.5460 1282.5618 -0.0159 0 40 0.0039 1 K.EGYYGYTGAFR.C 26007 708.3540 1414.6935 1414.7126 -0.0191 0 49 0.00053 1 K.SVIPSDGPSVACVK.K 26977 522.5490 1564.6251 1564.7919 -0.1668 1 1 27 3 K.DLLFRDDTVCLAK.L 28421 691.3508 2071.0305 2070.9204 0.1100 0 0 26 2 K.SDNCEDTPEAGYFAVAVVK.K

133. A8MW06|TMSL3_HUMAN Mass: 5060 Score: 121 Queries matched: 4 emPAI: 5.38 Thymosin beta-4-like protein 3 OS=Homo sapiens GN=TMSL3 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 25032 674.7982 1347.5818 1347.6154 -0.0336 1 75 1.7e-006 1 K.ETIEQEKQAGES.- 25031 25501 457.9003 1370.6790 1370.7041 -0.0251 1 25 0.14 1 K.TETQEKNPLPSK.E 26733 504.9258 1511.7556 1511.7831 -0.0275 1 56 0.00011 1 K.NPLPSKETIEQEK.Q

Proteins matching the same set of peptides: Q08EQ4|TMSL1_HUMAN Mass: 5067 Score: 121 Queries matched: 4 Thymosin beta-4-like protein 1 OS=Homo sapiens GN=TMSL1 PE=2 SV=1 A9Z1Y9|TMSL6_HUMAN Mass: 5040 Score: 121 Queries matched: 4 Thymosin beta-4-like protein 6 OS=Homo sapiens GN=TMSL6 PE=3 SV=1 P62328|TYB4_HUMAN Mass: 5050 Score: 121 Queries matched: 4 Thymosin beta-4 OS=Homo sapiens GN=TMSB4X PE=1 SV=2

134. Q5JXB2|UE2NL_HUMAN Mass: 17366 Score: 120 Queries matched: 10 emPAI: 0.50 Putative ubiquitin-conjugating enzyme E2 N-like OS=Homo sapiens GN=UBE2NL PE=5 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7966 414.2426 826.4706 826.3895 0.0811 0 6 11 2 R.LYAMNSI.- 7900 15528 493.2505 984.4865 984.5029 -0.0163 0 19 0.64 1 K.IYHPNVDK.L 15526 15629 494.7494 987.4842 987.4257 0.0584 0 5 20 9 K.AEPDESNAR.Y 17003 518.8150 1035.6154 1035.6328 -0.0174 0 50 0.00054 1 R.LLAEPVPGIK.A 17001 17002 17004 21787 602.2946 1202.5747 1202.5891 -0.0144 0 65 1.5e-005 1 K.TNEAQAIETAR.A

135. P07900|HS90A_HUMAN Mass: 85006 Score: 120 Queries matched: 16 emPAI: 0.19 Heat shock protein HSP 90-alpha OS=Homo sapiens GN=HSP90AA1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7435 408.2514 814.4881 814.5065 -0.0184 0 30 0.071 1 R.ALLFVPR.R 7434 7436 11876 440.2568 878.4991 878.4167 0.0823 0 3 33 3 R.EMLQQSK.I 12321 445.7473 889.4800 889.4141 0.0659 1 3 31 4 K.AEADKNDK.S

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16114 503.2643 1004.5141 1004.5576 -0.0435 1 4 27 4 K.IMKDILEK.K 17049 520.2436 1038.4725 1038.4869 -0.0144 0 41 0.0047 1 R.YESLTDPSK.L 20618 576.2741 1150.5337 1150.5506 -0.0169 0 48 0.00073 1 K.YIDQEELNK.T 20617 20995 584.7751 1167.5356 1167.5632 -0.0276 0 38 0.0073 1 K.LGIHEDSQNR.K 20996 22805 621.8444 1241.6742 1241.6979 -0.0238 0 50 0.00051 1 K.ADLINNLGTIAK.S 23926 432.8830 1295.6272 1295.6582 -0.0310 1 9 6 1 K.LGIHEDSQNRK.K 2085 23938 3998 470.2263 1407.6570 1407.6881 -0.0311 1 16 3.1 1 K.EKYIDQEELNK.T

136. P63244|GBLP_HUMAN Mass: 35511 Score: 120 Queries matched: 5 emPAI: 0.35 Guanine nucleotide-binding protein subunit beta-2-like 1 OS=Homo sapiens GN=GNB2L1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16193 505.2649 1008.5152 1008.4732 0.0420 0 1 44 10 -.MTEQMTLR.G 21384 596.7826 1191.5506 1191.5520 -0.0014 0 50 0.00046 1 R.DETNYGIPQR.A 21382 23236 632.8292 1263.6437 1263.6459 -0.0022 0 41 0.0034 1 R.LWDLTTGTTTR.R 24279 655.3122 1308.6099 1308.6310 -0.0211 0 52 0.00026 1 K.DVLSVAFSSDNR.Q

137. P28072|PSB6_HUMAN Mass: 25570 Score: 117 Queries matched: 6 emPAI: 0.32 Proteasome subunit beta type-6 OS=Homo sapiens GN=PSMB6 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18625 542.2612 1082.5077 1082.5356 -0.0279 0 44 0.0018 1 R.TTTGSYIANR.V 18627 18628 19595 558.2945 1114.5744 1114.5982 -0.0238 0 71 4.6e-006 1 R.LAAIAESGVER.Q 19594 6157

138. O60234|GMFG_HUMAN Mass: 16961 Score: 117 Queries matched: 14 emPAI: 0.51 Glia maturation factor gamma OS=Homo sapiens GN=GMFG PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12953 453.2357 904.4567 904.4695 -0.0127 0 39 0.0077 1 R.FVVYSYK.Y 12948 12952 12955 3416 13048 16011 501.7901 1001.5656 1001.5757 -0.0101 0 46 0.0017 1 R.LVQTAELTK.V 16005 16006 16008 16009 16010 5072 26396 488.5249 1462.5530 1462.7337 -0.1807 1 4 12 4 K.ETDNAAIIM KVDK.D

139. P62807|H2B1C_HUMAN Mass: 13811 Score: 114 Queries matched: 18 emPAI: 2.51 Histone H2B type 1-C/E/F/G/I OS=Homo sapiens GN=HIST1H2BC PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6332 570.3534 569.3462 569.3173 0.0289 0 8 16 1 K.SAPAPK.K 7447 408.7312 815.4479 815.4501 -0.0022 0 37 0.015 1 R.EIQTAVR.L 7445 7446 12497 449.2193 896.4241 896.4967 -0.0726 1 0 42 1 K.AVTKYTSK.- 12712 451.2502 900.4857 900.4929 -0.0072 1 52 0.00041 1 R.LAHYNKR.S 12719 14733 477.2946 952.5746 952.5957 -0.0210 0 40 0.0045 1 R.LLLPGELAK.H 14730 4393 14734 14735 4394 4395 20277 569.2696 1136.5246 1136.5390 -0.0143 0 41 0.0045 1 K.ESYSVYVYK.V 20280 20997 584.7902 1167.5658 1167.5884 -0.0226 0 41 0.0037 1 K.QVHPDTGISSK.A 20998

140. Q15149|PLEC1_HUMAN Mass: 533462 Score: 114 Queries matched: 179 emPAI: 0.05 Plectin-1 OS=Homo sapiens GN=PLEC1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5733 531.2882 530.2810 530.3064 -0.0254 0 9 29 1 R.ALAEK.M 6087 550.3086 549.3013 549.3122 -0.0109 1 0 55 3 R.KTSSK.S 6925 692.3651 691.3578 691.3323 0.0256 0 3 36 10 R.VAEMSR.A 7980 414.7468 827.4791 827.4865 -0.0074 0 28 0.087 1 R.VAQLLER.W 9582 422.7207 843.4268 843.4450 -0.0182 0 18 1.1 2 R.ELEQLGR.Q 9583 11650 437.2453 872.4760 872.4352 0.0408 0 3 34 6 K.QVAEEAAR.L 11663 437.2652 872.5158 872.4967 0.0191 0 3 36 9 R.LTVNEAVK.E 11737 437.7541 873.4937 873.4565 0.0373 0 18 1.3 1 M.VAGMLMPR.D 11674 11675 11677 11684 11686 11688 11689 11690 11764 438.2336 874.4526 874.4032 0.0494 0 3 39 7 R.AEEAEAQK.R 11807 439.1940 876.3734 876.4705 -0.0971 0 0 56 8 K.ATVSAPFGK.F 12253 444.7446 887.4746 887.4348 0.0398 0 10 6.5 7 R.ELAEEAAR.L 12605 450.2629 898.5113 898.5348 -0.0235 1 8 7.6 9 R.RDVQLIR.S 12601 12712 451.2502 900.4857 900.5029 -0.0171 0 17 1.3 3 K.LAAIGEATR.L 12717 451.2507 900.4869 900.5644 -0.0775 0 15 2.3 1 R.SSIAGLLLK.A 12734 12801 451.7552 901.4959 901.4869 0.0090 0 29 0.091 1 R.LTVDEAVR.A 12815 451.7596 901.5047 901.4869 0.0178 0 8 12 6 K.GLVEDTLR.Q 12804 12808 12841 12832 451.7644 901.5143 901.4505 0.0638 0 8 12 3 R.EAEGQLQK.L 13129 453.7437 905.4728 905.4463 0.0265 0 (11) 5.5 1 M.VAGMLMPR.D 13089 13111 13112 13124 13133 13151 453.7743 905.5340 905.4090 0.1250 0 3 30 1 K.ASDSELER.Q 13181 454.2155 906.4164 906.4593 -0.0429 1 10 6.3 3 R.NTNMTAKK.E 13258 455.7448 909.4751 909.5760 -0.1008 0 13 2.4 1 K.AVVQLKPR.H 13427 458.2349 914.4552 914.5185 -0.0633 0 (6) 14 1 K.GLLSAEVAR.L 13428 13461 13470 458.2674 914.5202 914.5338 -0.0135 0 3 30 2 K.LLLWSQR.M 13480 458.7362 915.4577 915.4661 -0.0084 0 10 5.8 3 K.AALEEVER.L 13643 460.2486 918.4826 918.5208 -0.0382 1 3 32 7 R.ALAEKMLK.E 14421 473.2301 944.4456 944.5039 -0.0583 1 7 13 1 R.EAAAATQKR.Q 14939 480.2660 958.5174 958.5083 0.0091 0 26 0.16 1 R.LQLEATER.Q 14937 15013 481.7386 961.4626 961.4716 -0.0090 0 15 1.9 1 R.SAEAELQSK.R 15318 488.2468 974.4791 974.4304 0.0486 0 8 9.6 1 R.AAEEAEEAR.V 4757 15312 4759 15317 15436 490.2548 978.4950 978.4692 0.0258 0 5 18 2 R.VQMEELSK.L 15673 495.2637 988.5128 988.5441 -0.0312 0 8 8.8 4 R.SELELTLGK.L 15675 495.2642 988.5139 988.4573 0.0566 1 13 2.8 1 K.EEAEREAR.R 15778 497.2482 992.4818 992.5655 -0.0836 0 1 46 8 R.LSYTQLLR.R 15932 501.2704 1000.5263 1000.5189 0.0074 0 19 0.69 1 K.AQAEVEGLGK.G 5039 15924 15993 501.7494 1001.4843 1001.4778 0.0066 0 19 0.72 2 R.QLAEEDAAR.Q 5104 503.2505 1004.4864 1004.4960 -0.0097 0 4 1.2e+002 4 R.LVASMEEAR.R 16322 508.2887 1014.5628 1014.5458 0.0170 0 52 0.00042 1 R.LSVAAQEAAR.L 16311 16556 512.2500 1022.4855 1022.5648 -0.0793 0 3 29 8 R.SLSAIYLEK.L 16809 516.2739 1030.5333 1030.5043 0.0290 1 9 7 1 R.KEAEQEAAR.R 17141 521.8030 1041.5915 1041.5818 0.0097 0 38 0.0092 1 R.LAAEQELIR.L 17467 523.7850 1045.5554 1045.5556 -0.0002 0 25 0.21 1 R.VPVDVAYQR.G 17546 525.7966 1049.5785 1049.5943 -0.0158 0 7 11 10 K.LISLFQAMK.K 17735 530.2599 1058.5053 1058.5356 -0.0304 0 10 5.4 1 R.GTQGAEEVLR.A 17781 530.7652 1059.5159 1059.5084 0.0075 0 27 0.14 1 R.VLADPSDDTK.G

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18335 537.3097 1072.6048 1072.6029 0.0019 0 7 13 3 K.SLLAWQSLR.R 18256 18271 18277 18284 18308 18872 545.7575 1089.5004 1089.5740 -0.0736 0 (10) 6.3 4 R.AEMEVLLASK.A 18873 18875 19274 553.7562 1105.4979 1105.5689 -0.0709 0 15 2 4 R.AEMEVLLASK.A 19266 19270 19272 19273 19275 19277 19278 1927 19304 553.7890 1105.5634 1105.6720 -0.1086 1 15 1.7 6 R.LHERLVAIR.T 19653 559.7891 1117.5637 1117.5727 -0.0090 1 11 4.3 7 R.SAEAELQSKR.A 19765 561.2963 1120.5781 1120.5261 0.0520 1 2 36 9 R.AEEDAQRFR.K 19782 561.4021 1120.7896 1120.6717 0.1180 1 3 9.7 2 K.GLILKDHGIR.L 20061 566.2944 1130.5743 1130.5567 0.0175 1 3 27 10 R.AGEVERDLDK.A 20065 566.7507 1131.4868 1131.4655 0.0214 0 14 2.3 2 R.GYFSEEMNR.V 20066 20068 20069 20070 20071 20073 20074 20077 20431 572.3095 1142.6045 1142.6044 0.0002 1 13 3.1 3 K.IKELQNAGDR.L 20432 20473 573.2738 1144.5330 1144.6274 -0.0944 1 4 19 1 K.GLVDKIMVDR.I 20474 20482 20629 576.3048 1150.5950 1150.5506 0.0444 0 6 14 7 R.QYDIDDAIAK.N 20864 582.2918 1162.5691 1162.5288 0.0403 0 19 0.61 1 R.QLEMSAEAER.L 6434 21109 589.3276 1176.6406 1176.5921 0.0485 1 3 25 1 R.LVASMEEARR.R 21194 590.2902 1178.5658 1178.5601 0.0057 1 6 14 4 R.DLDKADSMIR.L 21195 21203 6538 6571 593.8387 1185.6629 1185.6353 0.0276 1 3 24 8 K.RQELEAELAK.V 21806 402.2166 1203.6280 1203.5302 0.0978 0 3 27 2 R.QQQQMEQER.Q 21930 604.8068 1207.5991 1207.6747 -0.0756 0 6 11 7 R.HKPLLIDMNK.V 22676 412.8716 1235.5930 1235.6220 -0.0290 1 0 43 4 R.MGIVGPEFKDK.L 22810 622.3190 1242.6235 1242.6680 -0.0445 1 13 2 4 R.LQLEATERQR.G 22813 22814 22816 22818 23241 632.8392 1263.6639 1263.5765 0.0874 1 9 5.7 10 R.QKQAADAEMEK.H 23462 425.2136 1272.6189 1272.5768 0.0421 1 3 25 3 K.QAADAEMEKHK.K 23702 429.5839 1285.7300 1285.6374 0.0925 1 2 32 6 R.QLAEEDAARQR.A 23723 429.8990 1286.6752 1286.6830 -0.0078 0 4 19 3 K.AQVEQELTTLR.L 23988 650.2961 1298.5776 1298.7558 -0.1782 0 4 19 2 K.VTLVQTLEIQR.Q 24015 650.3815 1298.7484 1298.7063 0.0421 1 1 37 7 R.RPVAMVMPARR.T 24441 439.5313 1315.5720 1315.5615 0.0104 1 0 47 1 R.RGYFDEEMNR.V 25053 675.7771 1349.5397 1349.5484 -0.0087 0 48 0.00062 1 R.DSQDAGGFGPEDR.L 25669 694.3462 1386.6778 1386.6851 -0.0073 1 8 6.5 6 R.ARSDEGQLSPATR.G

141. Q9Y490|TLN1_HUMAN Mass: 271766 Score: 113 Queries matched: 55 emPAI: 0.10 Talin-1 OS=Homo sapiens GN=TLN1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7105 401.7086 801.4026 801.3981 0.0046 0 10 7.9 1 R.DVDNALR.A 7120 402.2346 802.4546 802.4436 0.0110 0 21 0.53 1 K.VLVEDTK.V 48 7135 403.2242 804.4339 804.4164 0.0175 0 11 5.4 3 R.AIADMLR.A 7131 7133 7134 9804 426.2394 850.4643 850.3854 0.0789 1 1 41 5 K.NKMDESK.H 11595 436.7589 871.5031 871.4875 0.0156 0 23 0.36 1 K.AVTQALNR.C 11579 11580 11581 11586 11587 11592 11745 437.7670 873.5194 873.4920 0.0274 1 9 9.7 6 K.TLLRDEK.K 2815 442.2062 882.3978 882.5287 -0.1309 0 6 25 6 K.LEQLKPR.A 2985 445.7274 889.4403 889.4327 0.0076 0 5 21 5 K.ELIECAR.R 12963 453.2397 904.4649 904.4185 0.0464 0 3 30 5 K.AVAAGNSCR.Q 13768 462.7043 923.3941 923.4270 -0.0329 0 7 9.9 2 K.TIMVDDSK.T 13766 13767 3785 14510 474.2550 946.4954 946.4971 -0.0017 0 2 38 9 K.ASSLIEEAK.K 14502 4864 493.2566 984.4985 984.3971 0.1015 0 1 1.5e+002 3 R.NGDTMEYR.K 15642 494.7870 987.5594 987.5600 -0.0006 0 37 0.013 1 K.ALGDLISATK.A 15944 501.2782 1000.5418 1000.3920 0.1498 0 (0) 60 4 R.NGDTMEYR.K 16221 506.2467 1010.4789 1010.6236 -0.1447 1 9 6.3 4 K.KLEQLKPR.A 16291 507.7935 1013.5725 1013.5618 0.0108 1 17 1.1 1 R.LREAAEGLR.M 16687 514.2683 1026.5221 1026.5934 -0.0713 1 0 49 2 K.RLQAAGNAVK.R 16843 516.3077 1030.6008 1030.6022 -0.0015 0 13 3 1 K.SIAAATSALVK.A 16788 16801 5618 523.7860 1045.5575 1045.5768 -0.0192 1 10 5.6 7 K.KEEITGTLR.K 17694 529.2866 1056.5586 1056.5927 -0.0341 0 3 25 5 K.NLGTALAELR.T 17768 530.7556 1059.4966 1059.5059 -0.0092 0 4 24 6 K.ALDYYMLR.N 18066 533.2655 1064.5165 1064.5138 0.0026 0 39 0.0069 1 K.TSTPEDFIR.M 5931 542.7520 1083.4895 1083.6652 -0.1757 0 5 18 4 K.AVASAAAALVLK.A 19813 562.2299 1122.4452 1122.4975 -0.0524 0 2 29 5 K.CTQDLGNSTK.A 20327 570.7796 1139.5447 1139.5935 -0.0488 0 4 18 3 R.ALEATTEHIR.Q 20326 20490 573.3138 1144.6130 1144.6088 0.0042 0 38 0.0088 1 K.EVANSTANLVK.T 20855 581.7704 1161.5261 1161.5051 0.0211 0 24 0.19 1 R.EGTETFADHR.E 20892 582.7872 1163.5598 1163.5791 -0.0193 1 14 2 2 R.AIADMLRACK.E 21247 591.2646 1180.5146 1180.5216 -0.0070 1 5 16 3 K.ECVMRVDEK.T 22308 611.7913 1221.5681 1221.5626 0.0055 0 24 0.23 1 K.ALDGAFTEENR.A 22819 622.3391 1242.6636 1242.6568 0.0068 0 66 1.2e-005 1 K.VLVQNAAGSQEK.L 24449 658.8206 1315.6267 1315.6732 -0.0464 0 13 2.7 2 R.QEDVIATANLSR.R 24448 24450 3968 469.2152 1404.6237 1404.8010 -0.1773 1 1 89 4 K.GISMSSSKLLLAAK.A 26026 709.3044 1416.5943 1416.7653 -0.1710 1 0 39 6 K.TYGVSFFLVKEK.M 26192 717.8702 1433.7259 1433.7184 0.0075 0 4 16 3 K.VLGEAMTGISQNAK.N 26340 485.9038 1454.6896 1454.7551 -0.0655 0 3 22 2 K.ASAGPQPLLVQSCK.A

142. P11215|ITAM_HUMAN Mass: 128410 Score: 113 Queries matched: 17 emPAI: 0.15 Integrin alpha-M OS=Homo sapiens GN=ITGAM PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11593 436.7500 871.4853 871.4875 -0.0022 0 14 2.4 1 K.TIQNQLR.E 11993 442.2491 882.4837 882.4746 0.0092 0 23 0.24 1 R.VCLHVQK.S 3846 464.7533 927.4920 927.5501 -0.0582 1 4 21 6 R.IAGSKLSPR.L 15505 492.7399 983.4652 983.5512 -0.0860 1 6 13 3 R.THTATGIRK.V 17067 520.3151 1038.6156 1038.6186 -0.0030 0 44 0.0021 1 R.VQSLVLGAPR.Y 17644 528.7549 1055.4953 1055.6702 -0.1750 1 12 3.3 8 K.ASLGNKLLLK.A 17641 18334 537.3088 1072.6030 1072.5989 0.0042 1 8 11 8 R.KVSTLQNQR.S 18702 543.8249 1085.6353 1085.6332 0.0020 0 25 0.16 1 K.ILVVITDGEK.F 19069 548.7488 1095.4830 1095.5713 -0.0883 0 1 40 2 R.YVIGVGDAFR.S 19576 558.2689 1114.5232 1114.5155 0.0076 0 32 0.031 1 K.EFQNNPNPR.S 6463 585.3140 1168.6134 1168.6023 0.0111 0 39 0.016 1 R.GGQVSVCPLPR.G 21006 25077 676.3202 1350.6259 1350.6238 0.0021 0 35 0.014 1 R.NVFECNDQVVK.G 25116 677.3647 1352.7148 1352.7412 -0.0264 0 14 1.8 1 R.QELNTIASKPPR.D 25115 25361 681.8595 1361.7045 1361.7052 -0.0007 0 73 2.4e-006 1 R.GFGQSVVQLQGSR.V

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143. P15090|FABP4_HUMAN Mass: 14824 Score: 111 Queries matched: 7 emPAI: 0.59 Fatty acid-binding protein, adipocyte OS=Homo sapiens GN=FABP4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14169 468.2446 934.4746 934.4872 -0.0126 0 50 0.00057 1 K.EVGVGFATR.K 14165 3957 14168 14170 26293 724.3704 1446.7262 1446.6337 0.0926 0 (2) 26 5 K.LVSSENFDDYMK.E 26397 732.3137 1462.6129 1462.6286 -0.0157 0 45 0.0011 1 K.LVSSENFDDYMK.E

144. Q6EEV6|SUMO4_HUMAN Mass: 10735 Score: 110 Queries matched: 5 emPAI: 0.37 Small ubiquitin-related modifier 4 OS=Homo sapiens GN=SUMO4 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 793 415.1564 828.2983 828.4817 -0.1834 1 1 69 1 K.RQTPLSK.L 14540 474.6947 947.3749 947.5222 -0.1473 1 1 49 5 R.GLSMKQIR.F 22570 617.8193 1233.6240 1233.6354 -0.0114 0 80 5.4e-007 1 K.VAGQDGSVVQFK.I 22573 26470 738.3755 1474.7365 1474.8144 -0.0779 1 8 6.4 9 K.VAGQDGSVVQFKIK.R

145. O75874|IDHC_HUMAN Mass: 46915 Score: 110 Queries matched: 13 emPAI: 0.26 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens GN=IDH1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7234 404.2251 806.4357 806.4286 0.0071 1 26 0.17 1 K.RVEEFK.L 13409 457.7779 913.5412 913.5596 -0.0184 1 10 5.3 2 K.LGENLKIK.L 13400 13407 13411 15380 488.7758 975.5369 975.5502 -0.0132 0 22 0.39 1 R.NILGGTVFR.E 16180 505.2263 1008.4380 1008.4413 -0.0033 0 18 0.77 1 R.HAYGDQYR.A 18720 544.2861 1086.5575 1086.5710 -0.0134 0 44 0.0027 1 R.ATDFVVPGPGK.V 18714 18723 24908 447.8911 1340.6516 1340.6684 -0.0168 0 28 0.084 1 K.TVEAEAAHGTVTR.H 24914 26220 719.8517 1437.6888 1437.6987 -0.0100 0 69 5.2e-006 1 K.VEITYTPSDGTQK.V

146. A8MT79|ZAGL1_HUMAN Mass: 23080 Score: 110 Queries matched: 5 emPAI: 0.17 Putative zinc-alpha-2-glycoprotein-like 1 OS=Homo sapiens PE=5 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19980 564.2786 1126.5426 1126.5618 -0.0192 0 63 2.6e-005 1 R.AGEVQEPELR.G 19975 19976 19979 19984

Proteins matching the same set of peptides: P25311|ZA2G_HUMAN Mass: 34079 Score: 110 Queries matched: 5 Zinc-alpha-2-glycoprotein OS=Homo sapiens GN=AZGP1 PE=1 SV=1

147. P61026|RAB10_HUMAN Mass: 22755 Score: 110 Queries matched: 14 emPAI: 0.59 Ras-related protein Rab-10 OS=Homo sapiens GN=RAB10 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7063 401.2205 800.4265 800.4392 -0.0127 0 46 0.002 1 K.ANINIEK.A 7997 415.2035 828.3924 828.4018 -0.0093 0 20 0.75 1 R.FFETSAK.A 12621 450.2659 898.5172 898.4800 0.0372 0 4 20 1 K.TYDLLFK.L 18220 536.3152 1070.6159 1070.6336 -0.0177 0 50 0.00061 1 K.LLLIGDSGVGK.T 5815 5817 18209 5823 18212 18214 18215 18217 1 24447 658.8179 1315.6213 1315.6521 -0.0308 0 29 0.068 1 K.LQIWDTAGQER.F

148. P30041|PRDX6_HUMAN Mass: 25133 Score: 110 Queries matched: 17 emPAI: 0.15 Peroxiredoxin-6 OS=Homo sapiens GN=PRDX6 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13084 453.7302 905.4458 905.4607 -0.0149 0 28 0.096 1 R.NFDEILR.V 3473 3474 13090 13450 458.2457 914.4769 914.4862 -0.0093 0 9 8 3 R.VATPVDWK.D 5154 504.2737 1006.5329 1006.5488 -0.0159 0 13 9.4 1 R.VVFVFGPDK.K 16143 5155 5451 519.2777 1036.5409 1036.5342 0.0068 1 7 43 2 K.YLRYTPQP.- 17017 17256 523.2744 1044.5342 1044.5967 -0.0626 1 6 16 1 R.AAKLAPEFAK.R 17274 17275 21378 596.3338 1190.6530 1190.6659 -0.0129 0 26 0.14 1 K.LSILYPATTGR.N 25813 698.3161 1394.6176 1394.6500 -0.0325 0 54 0.00018 1 R.DFTPVCTTELGR.A 25814 25815

149. P47755|CAZA2_HUMAN Mass: 33157 Score: 109 Queries matched: 14 emPAI: 0.24 F-actin-capping protein subunit alpha-2 OS=Homo sapiens GN=CAPZA2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7417 408.2300 814.4455 814.4450 0.0005 1 22 0.45 1 K.FDHLRK.E 7415 7416 10955 435.2696 868.5246 868.5243 0.0004 1 18 0.67 1 R.RQLPVTR.T 11799 438.7428 875.4711 875.4712 -0.0001 0 47 0.0014 1 R.TSVETALR.A 11796 11798 12347 446.2392 890.4639 890.4399 0.0240 1 3 30 1 R.WRSEWK.F 12343 13694 461.2530 920.4914 920.5695 -0.0781 1 11 4.6 2 K.ILSYKIGK.E 21620 599.3426 1196.6707 1196.6877 -0.0170 0 58 7.1e-005 1 R.LLLNNDNLLR.E 21619 21621 21622

150. P18206|VINC_HUMAN Mass: 124292 Score: 108 Queries matched: 28 emPAI: 0.16 Vinculin OS=Homo sapiens GN=VCL PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7119 402.2207 802.4268 802.4371 -0.0103 0 18 1 1 R.ALIQCAK.D 7125 402.7156 803.4166 803.4389 -0.0223 0 23 0.38 1 R.ALASIDSK.L 314 408.2398 814.4650 814.4661 -0.0010 1 2 1.1e+002 3 R.GALAEARK.I 936 417.2188 832.4231 832.4113 0.0118 0 1 2.2e+002 1 K.VGELCAGK.E 1018 419.7224 837.4302 837.4457 -0.0155 0 33 0.023 1 R.GLVAEGHR.L 10352 433.7286 865.4426 865.3963 0.0462 1 1 43 1 K.DTEAMKR.A 11583 436.7429 871.4712 871.4763 -0.0051 0 35 0.02 1 K.GNDIIAAAK.R 11637 437.2323 872.4501 872.4603 -0.0102 0 17 1.6 1 R.QILDEAGK.V 12876 452.2659 902.5173 902.4433 0.0741 0 8 10 5 -.MPVFHTR.T 3631 457.2684 912.5221 912.5141 0.0081 0 3 57 3 R.AVANSRPAK.A 3635 15923 501.2536 1000.4926 1000.5189 -0.0262 0 5 18 1 K.NQGIEEALK.N 5616 523.7693 1045.5240 1045.4564 0.0676 0 4 23 5 R.EVENSEDPK.F 18704 544.2311 1086.4476 1086.6033 -0.1556 1 3 33 6 R.EAEAASIKIR.T 19899 562.7803 1123.5460 1123.5253 0.0206 0 1 37 7 K.TISPMVMDAK.A 20995 584.7751 1167.5356 1167.5450 -0.0093 0 0 46 9 R.MALLMAEMSR.L 21799 602.7612 1203.5078 1203.6095 -0.1017 1 10 4.5 1 K.DIAKASDEVTR.L 23412 635.3258 1268.6370 1268.6725 -0.0354 0 46 0.0011 1 K.AVAGNISDPGLQK.S

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1639 428.9253 1283.7541 1283.7058 0.0483 1 1 37 8 K.TNRAVANSRPAK.A 24236 436.8844 1307.6314 1307.6279 0.0035 0 4 19 1 K.MTGLVDEAIDTK.S 24251 24528 661.3280 1320.6415 1320.6939 -0.0524 1 2 28 8 R.TDAGFTLRWVR.K 24696 444.8650 1331.5731 1331.6616 -0.0884 1 11 3.7 1 R.ARGQGSSPVAMQK.A 24708 24844 670.8239 1339.6332 1339.6410 -0.0078 1 12 2.6 2 K.RMALLMAEMSR.L 24993 673.3259 1344.6372 1344.6343 0.0029 1 0 47 6 K.IAELCDDPKER.D 25042 675.3051 1348.5956 1348.6259 -0.0303 1 12 3.7 1 R.EVENSEDPKFR.E 26419 735.8271 1469.6396 1469.6746 -0.0350 0 51 0.00032 1 R.DPSASPGDAGEQAIR.Q

151. P52565|GDIR1_HUMAN Mass: 23250 Score: 108 Queries matched: 5 emPAI: 0.58 Rho GDP-dissociation inhibitor 1 OS=Homo sapiens GN=ARHGDIA PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14591 475.2698 948.5251 948.5392 -0.0142 1 53 0.00028 1 K.YKEALLGR.V 14588 14589 15446 490.7411 979.4676 979.4875 -0.0199 0 33 0.026 1 K.YIQHTYR.K 27638 876.4103 1750.8061 1750.8301 -0.0240 0 49 0.00049 1 R.AEEYEFLTPVEEAPK.G

152. P40926|MDHM_HUMAN Mass: 35937 Score: 107 Queries matched: 14 emPAI: 0.22 Malate dehydrogenase, mitochondrial OS=Homo sapiens GN=MDH2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7586 411.7249 821.4352 821.4283 0.0069 1 8 8.3 5 K.KGEDFVK.T 7585 13880 464.7211 927.4276 927.4563 -0.0287 0 2 35 10 K.HGVYNPNK.I 15755 496.7699 991.5253 991.5338 -0.0086 0 51 0.00045 1 R.ANTFVAELK.G 4957 15753 15756 15757 18327 537.2954 1072.5763 1072.5764 -0.0001 0 45 0.0022 1 R.IQEAGTEVVK.A 18301 18314 18320 18325 18328

153. O15143|ARC1B_HUMAN Mass: 41722 Score: 107 Queries matched: 6 emPAI: 0.19 Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens GN=ARPC1B PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12362 446.7476 891.4807 891.4814 -0.0007 1 25 0.21 1 R.FQNLDKK.A 15797 497.7702 993.5258 993.5284 -0.0025 0 20 0.55 1 R.NAYVWTLK.G 23483 638.3399 1274.6652 1274.6830 -0.0179 0 53 0.00026 1 K.NSVSQISVLSGGK.A 27040 528.2653 1581.7741 1581.7787 -0.0046 0 10 4 1 K.EVEERPAPTPWGSK.M 27248 543.5965 1627.7675 1627.7802 -0.0126 0 64 1.6e-005 1 K.ASSEGGTAAGAGLDSLHK.N 27249

154. Q71UI9|H2AV_HUMAN Mass: 13501 Score: 107 Queries matched: 14 emPAI: 1.15 Histone H2A.V OS=Homo sapiens GN=H2AFV PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7117 402.2190 802.4233 802.4409 -0.0176 1 0 69 4 K.AVSRSQR.A 9777 425.7628 849.5111 849.5184 -0.0074 0 36 0.015 1 R.HLQLAIR.G 9778 13422 458.2245 914.4345 914.4682 -0.0337 1 9 7.2 4 K.TRTTSHGR.V 14413 472.7652 943.5159 943.5240 -0.0080 0 53 0.00033 1 R.AGLQFPVGR.I 14400 14402 14404 14408 14410 14414 14415 6170 559.7782 1117.5419 1117.5503 -0.0084 0 46 0.0014 1 R.GDEELDSLIK.A 25462 685.8919 1369.7692 1369.7830 -0.0138 0 4 17 1 K.ATIAGGGVIPHIHK.S

155. P60842|IF4A1_HUMAN Mass: 46353 Score: 105 Queries matched: 13 emPAI: 0.36 Eukaryotic initiation factor 4A-I OS=Homo sapiens GN=EIF4A1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 284 407.7440 813.4735 813.4782 -0.0047 0 9 7.8 2 R.AILPCIK.G 8049 416.2084 830.4022 830.4035 -0.0012 0 20 0.74 1 R.ENYIHR.I 11907 441.1667 880.3188 880.3709 -0.0520 0 4 19 2 -.MSASQDSR.S 12304 445.7296 889.4446 889.4545 -0.0099 0 5 20 5 K.VDWLTEK.M 14131 467.7516 933.4886 933.4702 0.0184 1 2 44 3 K.ERDVIMR.E 14845 479.2645 956.5144 956.5291 -0.0147 0 46 0.0014 1 R.ELAQQIQK.V 14887 17751 530.2829 1058.5511 1058.5608 -0.0096 0 33 0.026 1 K.EELTLEGIR.Q 5778 533.2757 1064.5368 1064.5437 -0.0069 1 2 1.4e+002 5 R.DVIMREFR.S 18099 533.7442 1065.4739 1065.5389 -0.0650 1 8 7.8 3 R.VFDMLNRR.Y 18113 19570 557.8387 1113.6629 1113.6758 -0.0128 0 29 0.063 1 R.VLITTDLLAR.G 25806 697.8445 1393.6744 1393.6838 -0.0093 0 71 3.9e-006 1 K.GYDVIAQAQSGTGK.T

156. P58546|MTPN_HUMAN Mass: 13058 Score: 104 Queries matched: 1 emPAI: 0.30 Myotrophin OS=Homo sapiens GN=MTPN PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 27627 874.4020 1746.7894 1746.8424 -0.0530 0 104 1.5e-009 1 K.GPDGLTAFEATDNQAIK.A

157. O00182|LEG9_HUMAN Mass: 39835 Score: 104 Queries matched: 7 emPAI: 0.09 Galectin-9 OS=Homo sapiens GN=LGALS9 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7957 414.2345 826.4544 826.4661 -0.0117 0 6 11 7 R.NLPTINR.L 7962 14579 475.2397 948.4648 948.4665 -0.0017 0 54 0.00024 1 R.FDENAVVR.N 14571 14577 14578 14580

158. Q9H4G4|GAPR1_HUMAN Mass: 17322 Score: 103 Queries matched: 2 emPAI: 0.50 Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens GN=GLIPR2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22976 627.3004 1252.5862 1252.6048 -0.0185 0 80 5e-007 1 K.ASASDGSSFVVAR.Y 26325 727.3356 1452.6566 1452.6844 -0.0279 0 48 0.00064 1 R.EAQQYSEALASTR.I

159. Q14533|KRT81_HUMAN Mass: 56875 Score: 103 Queries matched: 45 emPAI: 0.37 Keratin, type II cuticular Hb1 OS=Homo sapiens GN=KRT81 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.L 13068 13069 13070 13071 13072 13073 13075 13076 130 14637 476.2336 950.4526 950.4709 -0.0183 0 7 12 2 R.LYEEEIR.I 15197 487.2483 972.4820 972.4876 -0.0056 0 32 0.038 1 R.LLEGEEQR.L 15279 487.7597 973.5048 973.5080 -0.0032 0 31 0.048 1 R.LTAEVENAK.C 16810 516.2769 1030.5393 1030.5294 0.0099 1 35 0.019 1 K.QEEKEQIK.S 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.L

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22302 611.7383 1221.4621 1221.4932 -0.0311 0 37 0.0076 1 R.EAECVEADSGR.L

Proteins matching the same set of peptides: O43790|KRT86_HUMAN Mass: 55120 Score: 103 Queries matched: 45 Keratin, type II cuticular Hb6 OS=Homo sapiens GN=KRT86 PE=1 SV=1 P78385|KRT83_HUMAN Mass: 55928 Score: 103 Queries matched: 45 Keratin, type II cuticular Hb3 OS=Homo sapiens GN=KRT83 PE=1 SV=2

160. Q15365|PCBP1_HUMAN Mass: 37987 Score: 102 Queries matched: 7 emPAI: 0.21 Poly(rC)-binding protein 1 OS=Homo sapiens GN=PCBP1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13544 459.2458 916.4770 916.4726 0.0044 1 10 7.6 3 R.IREESGAR.I 13550 17625 528.2658 1054.5170 1054.4423 0.0747 1 1 44 8 R.LSSEKGMGCS.- 18693 543.7666 1085.5185 1085.5465 -0.0280 0 45 0.0019 1 K.IANPVEGSSGR.Q 18692 23745 644.7990 1287.5835 1287.5877 -0.0042 0 61 3.8e-005 1 R.INISEGNCPER.I 23746

161. P61604|CH10_HUMAN Mass: 10925 Score: 102 Queries matched: 5 emPAI: 1.56 10 kDa heat shock protein, mitochondrial OS=Homo sapiens GN=HSPE1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13195 454.2491 906.4835 906.4963 -0.0128 0 8 9.5 2 K.FLPLFDR.V 16259 507.2705 1012.5265 1012.5553 -0.0288 0 45 0.0014 2 K.GGEIQPVSVK.V 18444 538.7913 1075.5680 1075.5914 -0.0233 0 42 0.0038 1 K.VLLPEYGGTK.V 24429 658.3648 1314.7151 1314.7507 -0.0357 0 72 3.1e-006 1 K.VLQATVVAVGSGSK.G 26462 738.3647 1474.7148 1474.8031 -0.0883 1 6 12 9 K.VGDKVLLPEYGGTK.V

162. P60983|GMFB_HUMAN Mass: 16874 Score: 99 Queries matched: 8 emPAI: 0.23 Glia maturation factor beta OS=Homo sapiens GN=GMFB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3724 460.2414 918.4682 918.4851 -0.0169 0 4 1.2e+002 1 R.FIVYSYK.Y 16011 501.7901 1001.5656 1001.5757 -0.0101 0 46 0.0017 1 K.LVQTAELTK.V 16005 16006 16008 16009 16010 5072

163. P06748|NPM_HUMAN Mass: 32726 Score: 98 Queries matched: 11 emPAI: 0.12 Nucleophosmin OS=Homo sapiens GN=NPM1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12168 444.2240 886.4333 886.4872 -0.0539 1 5 23 6 K.SIRDTPAK.N 13997 466.2324 930.4501 930.4658 -0.0157 0 43 0.003 1 K.GPSSVEDIK.A 13994 13995 13996 13999 14000 14001 14005 14006 140

164. Q71DI3|H32_HUMAN Mass: 15436 Score: 98 Queries matched: 12 emPAI: 0.97 Histone H3.2 OS=Homo sapiens GN=HIST2H3A PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8066 416.2327 830.4509 830.4861 -0.0352 0 47 0.0013 1 K.STELLIR.K 904 905 8073 9744 425.7217 849.4288 849.4232 0.0056 0 49 0.00085 1 R.EIAQDFK.T 9741 9752 16863 516.7945 1031.5744 1031.5876 -0.0132 0 32 0.04 1 R.YRPGTVALR.E 16861 16862 16865 24723 445.9037 1334.6894 1334.6830 0.0063 1 0 42 2 R.EIAQDFKTDLR.F

Proteins matching the same set of peptides: Q16695|H31T_HUMAN Mass: 15613 Score: 98 Queries matched: 12 Histone H3.1t OS=Homo sapiens GN=HIST3H3 PE=1 SV=3 P68431|H31_HUMAN Mass: 15509 Score: 98 Queries matched: 12 Histone H3.1 OS=Homo sapiens GN=HIST1H3A PE=1 SV=2 P84243|H33_HUMAN Mass: 15376 Score: 98 Queries matched: 12 Histone H3.3 OS=Homo sapiens GN=H3F3A PE=1 SV=2

165. Q01105|SET_HUMAN Mass: 33469 Score: 98 Queries matched: 6 emPAI: 0.24 Protein SET OS=Homo sapiens GN=SET PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7454 408.7509 815.4873 815.4865 0.0008 1 25 0.24 1 K.RSELIAK.I 21926 604.8017 1207.5889 1207.5972 -0.0083 0 62 3.1e-005 1 R.VEVTEFEDIK.S 21915 21925 26289 482.8852 1445.6336 1445.6423 -0.0087 0 29 0.061 1 K.EFHLNESGDPSSK.S 26290

166. P25398|RS12_HUMAN Mass: 14905 Score: 97 Queries matched: 8 emPAI: 1.01 40S ribosomal protein S12 OS=Homo sapiens GN=RPS12 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15145 485.7459 969.4773 969.5356 -0.0583 1 5 15 3 K.IDREGKPR.K 5498 521.7558 1041.4971 1041.5019 -0.0048 0 40 0.0059 1 K.DVIEEYFK.C 17128 17861 531.2693 1060.5241 1060.5376 -0.0134 0 36 0.014 1 K.LGEWVGLCK.I 17868 18119 533.8014 1065.5882 1065.5931 -0.0049 0 42 0.0034 1 K.TALIHDGLAR.G 18118 22578 412.2201 1233.6386 1233.6574 -0.0188 1 16 1.3 1 R.KVVGCSCVVVK.D

167. P62820|RAB1A_HUMAN Mass: 22891 Score: 94 Queries matched: 14 emPAI: 0.59 Ras-related protein Rab-1A OS=Homo sapiens GN=RAB1A PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15696 495.7394 989.4642 989.4818 -0.0176 0 29 0.077 1 R.TITSSYYR.G 15697 18220 536.3152 1070.6159 1070.6336 -0.0177 0 50 0.00061 1 K.LLLIGDSGVGK.S 5815 5817 18209 5823 18212 18214 18215 18217 1 22220 609.8092 1217.6039 1217.5823 0.0216 1 1 45 8 K.RMGPGATAGGAEK.S 24447 658.8179 1315.6213 1315.6521 -0.0308 0 29 0.068 1 K.LQIWDTAGQER.F

168. P78386|KRT85_HUMAN Mass: 57306 Score: 94 Queries matched: 46 emPAI: 0.21 Keratin, type II cuticular Hb5 OS=Homo sapiens GN=KRT85 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13103 453.7355 905.4564 905.4607 -0.0042 0 40 0.0058 1 R.FLEQQNK.L 13068 13069 13070 13071 13072 13073 13075 13076 130 14637 476.2336 950.4526 950.4709 -0.0183 0 7 12 2 R.LYEEEIR.V 15309 488.2272 974.4398 974.4062 0.0336 1 4 29 4 -.MSCRSYR.I

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15795 497.7574 993.5002 993.4623 0.0378 0 5 16 4 K.QDMACLLK.E 16583 512.7391 1023.4636 1023.4621 0.0015 0 12 3.1 1 K.AQYDDVASR.S 16810 516.2769 1030.5393 1030.5294 0.0099 1 35 0.019 1 K.QEEKEQIK.S 20824 581.2852 1160.5559 1160.6302 -0.0743 1 13 2.6 1 K.VRFLEQQNK.L 22302 611.7383 1221.4621 1221.4932 -0.0311 0 37 0.0076 1 R.EAECVEADSGR.L

169. P60900|PSA6_HUMAN Mass: 27838 Score: 94 Queries matched: 4 emPAI: 0.47 Proteasome subunit alpha type-6 OS=Homo sapiens GN=PSMA6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20806 580.7954 1159.5762 1159.5913 -0.0151 0 25 0.16 1 R.LYQVEYAFK.A 22229 609.8213 1217.6280 1217.6438 -0.0158 1 25 0.16 1 R.GKDCAVIVTQK.K 23687 643.3590 1284.7035 1284.7150 -0.0115 0 89 6.2e-008 1 K.AINQGGLTSVAVR.G 3516 454.1990 1359.5751 1359.7398 -0.1648 0 1 1.1e+002 6 K.LLDSSTVTHLFK.I

170. P10768|ESTD_HUMAN Mass: 31956 Score: 94 Queries matched: 3 emPAI: 0.12 S-formylglutathione hydrolase OS=Homo sapiens GN=ESD PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 23461 637.3089 1272.6033 1272.5986 0.0047 0 80 5.2e-007 1 K.AFSGYLGTDQSK.W 23456 23459

171. O14818|PSA7_HUMAN Mass: 28041 Score: 92 Queries matched: 6 emPAI: 0.13 Proteasome subunit alpha type-7 OS=Homo sapiens GN=PSMA7 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16329 508.7559 1015.4972 1015.5410 -0.0438 1 9 7.2 10 K.LQDERTVR.K 16331 18650 542.7972 1083.5799 1083.5811 -0.0012 0 27 0.095 1 K.ILNPEEIEK.Y 19162 550.8209 1099.6272 1099.6237 0.0035 0 55 0.00017 1 K.ALLEVVQSGGK.N 19160 19161

172. P47756|CAPZB_HUMAN Mass: 31616 Score: 92 Queries matched: 7 emPAI: 0.25 F-actin-capping protein subunit beta OS=Homo sapiens GN=CAPZB PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19437 554.8295 1107.6444 1107.6400 0.0044 1 31 0.039 1 R.RLPPQQIEK.N 19435 21029 586.3016 1170.5887 1170.5921 -0.0033 0 44 0.0023 1 R.STLNEIYFGK.T 6479 21027 21028 23193 631.8210 1261.6273 1261.6336 -0.0063 1 2 33 6 R.LVEDMENKIR.S

173. P53004|BIEA_HUMAN Mass: 33692 Score: 91 Queries matched: 4 emPAI: 0.37 Biliverdin reductase A OS=Homo sapiens GN=BLVRA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13694 461.2530 920.4914 920.4967 -0.0053 0 13 3.3 1 K.LLGQFSEK.E 15649 494.7963 987.5781 987.5866 -0.0085 0 40 0.0058 1 K.FGVVVVGVGR.A 15719 496.2586 990.5025 990.5134 -0.0109 0 38 0.0097 1 K.DQNIFVQK.L 25983 707.3610 1412.7075 1412.7260 -0.0184 0 61 3.4e-005 1 K.SGSLENVPNVGVNK.N

174. P30273|FCERG_HUMAN Mass: 9775 Score: 91 Queries matched: 4 emPAI: 1.00 High affinity immunoglobulin epsilon receptor subunit gamma OS=Homo sapiens GN=FCER1G PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11950 441.7241 881.4337 881.4494 -0.0157 0 40 0.0045 1 K.AAITSYEK.S 11947 20695 578.2755 1154.5365 1154.5568 -0.0203 0 56 0.00012 1 K.SDGVYTGLSTR.N 20694

175. Q00610|CLH1_HUMAN Mass: 193260 Score: 90 Queries matched: 20 emPAI: 0.12 Clathrin heavy chain 1 OS=Homo sapiens GN=CLTC PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7864 413.2506 824.4866 824.4796 0.0070 0 33 0.026 1 R.IAAYLFK.G 7847 7980 414.7468 827.4791 827.4177 0.0613 0 9 7.2 4 R.AVNYFSK.V 10168 429.7487 857.4829 857.4719 0.0110 1 2 48 3 R.TPDTIRR.F 12058 443.2147 884.4149 884.4028 0.0121 0 15 1.8 1 R.AYEFAER.C 12057 4012 470.7281 939.4415 939.4522 -0.0107 0 3 24 1 R.SVQNHNNK.S 14253 17144 522.2296 1042.4447 1042.4356 0.0092 0 24 0.23 1 R.ENPYYDSR.V 17629 528.2720 1054.5295 1054.5699 -0.0404 0 2 34 3 K.YIEIYVQK.V 18158 535.2764 1068.5383 1068.5386 -0.0003 0 27 0.092 1 R.AHIAQLCEK.A 20365 571.2812 1140.5478 1140.6615 -0.1137 1 2 34 5 K.GILRTPDTIR.R 20999 585.2257 1168.4369 1168.4455 -0.0086 0 25 0.11 1 R.ESNCYDPER.V 21282 592.7624 1183.5103 1183.5002 0.0101 0 45 0.0014 1 K.EVCFACVDGK.E 21592 599.2610 1196.5075 1196.5972 -0.0896 1 10 4.8 1 R.TRVMEYINR.L 21581 21584 24712 667.8251 1333.6355 1333.6262 0.0093 0 50 0.0005 1 K.IYIDSNNNPER.F 25433 456.9091 1367.7055 1367.6906 0.0149 0 31 0.039 1 K.NNRPSEGPLQTR.L 32802 516.0805 3090.4394 3090.4402 -0.0008 0 2 11 1 R.ECFGACLFTCYDLLRPDVVLETAWR.H

176. Q14847|LASP1_HUMAN Mass: 30097 Score: 90 Queries matched: 23 emPAI: 0.43 LIM and SH3 domain protein 1 OS=Homo sapiens GN=LASP1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9717 425.2325 848.4505 848.4644 -0.0139 0 39 0.0077 1 K.IVYPTEK.V 9710 9715 9716 9718 9719 9721 9722 9723 15169 486.7352 971.4558 971.4600 -0.0042 1 11 5.2 1 R.YKEEFEK.N 15167 17433 523.7714 1045.5283 1045.5404 -0.0120 0 40 0.0069 1 K.TQDQISNIK.Y 17398 5616 17427 17438 17439 17456 26261 481.9324 1442.7753 1442.7841 -0.0088 1 19 0.59 1 R.LKQQSELQSQVR.Y 26258 26260 26262 26263

177. P28065|PSB9_HUMAN Mass: 23364 Score: 90 Queries matched: 3 emPAI: 0.16 Proteasome subunit beta type-9 OS=Homo sapiens GN=PSMB9 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15930 501.2612 1000.5079 1000.5302 -0.0222 0 61 4.6e-005 1 R.VSAGEAVVNR.V 15927 15931

178. P51149|RAB7A_HUMAN Mass: 23760 Score: 88 Queries matched: 7 emPAI: 0.16 Ras-related protein Rab-7a OS=Homo sapiens GN=RAB7A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17695 529.2991 1056.5836 1056.6179 -0.0344 0 63 3e-005 1 K.VIILGDSGVGK.T 17694 17696 17697 17698

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21592 599.2610 1196.5075 1196.5859 -0.0784 0 7 8.9 3 K.TSLMNQYVNK.K 6606

179. P15144|AMPN_HUMAN Mass: 109870 Score: 88 Queries matched: 12 emPAI: 0.14 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12144 443.7597 885.5049 885.5032 0.0017 0 13 3.3 1 K.IQTQLQR.D 12722 451.2548 900.4950 900.4916 0.0034 0 37 0.013 1 R.ALEQALEK.T 14821 479.2351 956.4557 956.5403 -0.0846 0 6 16 2 K.QASNGVLIR.I 4436 16292 507.8015 1013.5885 1013.5982 -0.0096 1 32 0.037 1 R.KIQTQLQR.D 17760 530.7368 1059.4590 1059.5423 -0.0833 1 6 17 2 -.MAKGFYISK.S 17762 19772 561.3064 1120.5982 1120.5989 -0.0007 0 39 0.0063 1 R.DHSAIPVINR.A 21018 585.2965 1168.5784 1168.5724 0.0060 0 1 37 3 R.GVGGSQPPDIDK.T 22388 409.2343 1224.6810 1224.6714 0.0096 0 8 7 1 K.EATDVIIIHSK.K 23409 635.2765 1268.5384 1268.5269 0.0115 0 63 2.3e-005 1 K.DNEETGFGSGTR.A 2309 435.2585 1302.7537 1302.6932 0.0605 0 1 1.6e+002 1 R.LPNTLKPDSYR.V

180. P35241|RADI_HUMAN Mass: 68635 Score: 87 Queries matched: 20 emPAI: 0.23 Radixin OS=Homo sapiens GN=RDX PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7235 404.2254 806.4362 806.3592 0.0770 0 8 9.3 4 K.QAADQMK.N 8064 416.2275 830.4405 830.4134 0.0271 0 9 9.3 4 R.AQLENEK.K 8066 416.2327 830.4509 830.4359 0.0151 1 10 7.9 6 R.QGNTKQR.I 8180 419.2056 836.3967 836.4028 -0.0061 0 21 0.42 1 R.NISFNDK.K 11766 438.2351 874.4556 874.4548 0.0007 0 20 0.7 1 K.ENPLQFK.F 3041 447.7733 893.5321 893.5375 -0.0054 0 10 5.1 1 R.LFFLQVK.E 14931 480.2398 958.4650 958.5083 -0.0433 1 6 15 1 R.AQLENEKK.K 14948 480.2915 958.5684 958.5851 -0.0167 0 21 0.46 1 K.FVIKPIDK.K 15062 483.2559 964.4973 964.4978 -0.0005 1 18 0.88 1 R.NISFNDKK.F 15060 15196 487.2466 972.4785 972.4876 -0.0090 0 14 2.7 1 K.ALELDQER.K 4776 488.7723 975.5300 975.5389 -0.0089 0 25 0.21 1 K.QLFDQVVK.T 16049 502.2747 1002.5348 1002.5498 -0.0150 1 22 0.37 1 K.KENPLQFK.F 18519 540.2545 1078.4943 1078.4964 -0.0021 1 27 0.11 1 R.EKEELMER.L 18520 18730 544.3424 1086.6703 1086.6801 -0.0098 1 35 0.018 1 K.FVIKPIDKK.A 18746 544.7648 1087.5151 1087.5873 -0.0722 1 1 44 9 R.AAEEAKSAIAK.Q 6548 591.7980 1181.5814 1181.5869 -0.0055 0 38 0.0074 1 K.APDFVFYAPR.L 22468 616.2982 1230.5818 1230.6204 -0.0386 1 58 9.5e-005 1 K.AQKELEEQTR.K 26590 496.9333 1487.7780 1487.7766 0.0014 1 6 9.4 1 R.RKPDTIEVQQMK.A

181. O75348|VATG1_HUMAN Mass: 13863 Score: 86 Queries matched: 3 emPAI: 0.28 V-type proton ATPase subunit G 1 OS=Homo sapiens GN=ATP6V1G1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15192 487.2342 972.4537 972.5352 -0.0815 1 7 14 4 K.AKEAAALGSR.G 4698 25387 683.3103 1364.6061 1364.6208 -0.0146 0 86 1.1e-007 1 K.EEAQAEIEQYR.L

182. P50395|GDIB_HUMAN Mass: 51087 Score: 86 Queries matched: 9 emPAI: 0.24 Rab GDP dissociation inhibitor beta OS=Homo sapiens GN=GDI2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13074 453.7267 905.4389 905.4494 -0.0106 0 38 0.011 1 R.TFEGIDPK.K 13116 13397 457.7638 913.5129 913.4804 0.0326 1 1 41 2 K.KVLHMDR.N 14227 469.7473 937.4800 937.4869 -0.0068 0 32 0.031 1 K.LYSESLAR.Y 14225 16761 515.2648 1028.5150 1028.5179 -0.0029 0 20 0.55 1 K.VTEGSFVYK.G 16762 25399 683.3547 1364.6949 1364.6936 0.0013 0 63 2.6e-005 1 K.DLGTESQIFISR.T 26036 709.8176 1417.6207 1417.7024 -0.0817 1 5 15 3 R.FKIPGSPPESMGR.G

183. Q9Y696|CLIC4_HUMAN Mass: 28982 Score: 86 Queries matched: 8 emPAI: 0.28 Chloride intracellular channel protein 4 OS=Homo sapiens GN=CLIC4 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15573 494.2497 986.4848 986.4821 0.0027 0 57 0.00011 1 R.YLTNAYSR.D 4887 15572 25566 690.3562 1378.6978 1378.7092 -0.0114 1 17 1.1 2 K.EVEIAYSDVAKR.L 25562 25564 25659 693.3408 1384.6671 1384.6694 -0.0024 0 43 0.0023 1 K.NSRPEANEALER.G 25658

184. P17931|LEG3_HUMAN Mass: 26193 Score: 84 Queries matched: 12 emPAI: 0.72 Galectin-3 OS=Homo sapiens GN=LGALS3 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8086 416.2439 830.4733 830.4861 -0.0128 1 34 0.032 2 K.KLNEISK.L 8097 1764 431.7377 861.4608 861.4708 -0.0100 0 35 0.024 1 R.IALDFQR.G 1761 1762 1763 1765 1766 11667 437.7137 873.4129 873.4093 0.0036 0 11 6 1 K.LDNNWGR.E 23462 425.2136 1272.6189 1272.6000 0.0189 0 43 0.0023 1 R.GNDVAFHFNPR.F 23460 24574 442.2478 1323.7216 1323.7187 0.0029 0 32 0.027 1 K.IQVLVEPDHFK.V

185. Q8IUE6|H2A2B_HUMAN Mass: 13987 Score: 84 Queries matched: 10 emPAI: 0.28 Histone H2A type 2-B OS=Homo sapiens GN=HIST2H2AB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2831 442.2937 882.5728 882.4559 0.1169 0 0 79 1 K.TESHKPGK.N 14413 472.7652 943.5159 943.5240 -0.0080 0 53 0.00033 1 R.AGLQFPVGR.V 14400 14402 14404 14408 14410 14414 14415 19913 563.2578 1124.5010 1124.5938 -0.0927 1 0 48 4 K.TESHKPGKNK.-

186. P35754|GLRX1_HUMAN Mass: 12053 Score: 84 Queries matched: 5 emPAI: 1.34 Glutaredoxin-1 OS=Homo sapiens GN=GLRX PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11172 435.7647 869.5148 869.5334 -0.0186 1 47 0.00086 1 R.LKQIGALQ.- 11113 2361 22754 620.3589 1238.7032 1238.7234 -0.0202 0 64 1.9e-005 1 R.AQEILSQLPIK.Q 27284 546.9440 1637.8101 1637.8422 -0.0321 0 19 0.44 1 K.VVVFIKPTCPYCR.R

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187. P20702|ITAX_HUMAN Mass: 128946 Score: 84 Queries matched: 20 emPAI: 0.15 Integrin alpha-X OS=Homo sapiens GN=ITGAX PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11672 437.7348 873.4550 873.5032 -0.0482 1 4 28 5 R.SKNLLGSR.D 13575 459.7482 917.4819 917.4930 -0.0111 0 41 0.0051 1 R.IAGSQLSSR.L 13585 15080 483.7437 965.4728 965.4501 0.0227 0 12 3.4 3 K.ESHVAMHR.Y 15703 495.7661 989.5176 989.5393 -0.0217 0 39 0.0083 1 R.AQTTTVLEK.Y 15706 16512 510.7997 1019.5848 1019.5764 0.0084 0 37 0.012 1 K.AVIFTQVSR.Q 18902 546.2805 1090.5465 1090.5519 -0.0054 0 30 0.062 1 R.YQVNNLGQR.D 18900 19582 558.2762 1114.5378 1114.5982 -0.0604 1 11 4.7 7 K.DIQNQLKEK.I 19578 19583 19584 19585 19587 19588 19589 19590 6463 585.3140 1168.6134 1168.6023 0.0111 0 39 0.016 1 R.GGQVSVCPLPR.G 21006

188. P46940|IQGA1_HUMAN Mass: 189761 Score: 82 Queries matched: 33 emPAI: 0.08 Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens GN=IQGAP1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 27 401.2166 800.4186 800.4293 -0.0107 0 19 3.1 1 K.ATGLHFR.H 7064 8044 415.7437 829.4729 829.4657 0.0072 0 18 1.1 1 K.ELATLQR.Q 8040 12030 442.7550 883.4954 883.5855 -0.0901 1 3 27 6 K.IGLLVKNK.I 13249 455.2464 908.4782 908.4756 0.0026 0 58 8.3e-005 1 K.LGNFFSPK.V 13248 13836 464.2444 926.4742 926.4419 0.0323 0 4 19 3 R.YLDELMK.L 13832 3822 3826 14014 466.2515 930.4884 930.5022 -0.0138 0 22 0.41 1 K.TALQEEIK.S 13999 14012 3899 14325 471.7398 941.4651 941.5155 -0.0504 1 4 22 8 R.GARGQNALR.Q 14644 476.2361 950.4576 950.4491 0.0085 1 2 36 5 K.QDKMTNAK.N 16514 511.2624 1020.5101 1020.4910 0.0192 0 11 4.4 1 K.TCLDNLASK.G 16659 513.3059 1024.5973 1024.6029 -0.0056 0 32 0.033 1 R.ALQSPALGLR.G 16611 18230 536.7738 1071.5330 1071.5812 -0.0482 0 8 12 7 K.LTELGTVDPK.N 18228 18232 18965 547.2569 1092.4993 1092.4757 0.0236 0 6 14 5 R.LTAEEMDER.R 20950 584.2881 1166.5617 1166.6196 -0.0580 1 1 40 7 R.GYLVRQEFR.S 6454 584.9026 1167.7906 1167.6209 0.1697 1 10 4.8 3 R.YLDELMKLK.A 21998 606.3599 1210.7053 1210.6532 0.0520 1 1 36 7 K.IPYGMRFIAK.V 22588 412.2249 1233.6530 1233.6353 0.0176 0 4 23 4 K.YQELINDIAR.D 22683 618.8439 1235.6733 1235.6510 0.0223 0 37 0.0086 1 K.LQQTYAALNSK.A 24199 653.3344 1304.6543 1304.6646 -0.0103 1 8 6.6 9 K.EIMDDKSLNIK.T 24198 24200 27411 420.7602 1679.0119 1678.9142 0.0977 1 1 19 6 R.AVTDKFLSAIVSSVDK.I

189. P61224|RAP1B_HUMAN Mass: 21040 Score: 82 Queries matched: 5 emPAI: 0.18 Ras-related protein Rap-1b OS=Homo sapiens GN=RAP1B PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 683 413.2355 824.4564 824.4868 -0.0304 1 2 81 1 K.TPVPGKAR.K 15545 493.2948 984.5750 984.5968 -0.0218 0 62 3.2e-005 1 K.LVVLGSGGVGK.S 15544 15546 15548

190. Q14103|HNRPD_HUMAN Mass: 38581 Score: 82 Queries matched: 8 emPAI: 0.20 Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens GN=HNRNPD PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16281 507.7487 1013.4828 1013.5618 -0.0790 1 8 10 4 K.LDPITGRSR.G 16275 16276 16321 508.2886 1014.5626 1014.5022 0.0605 1 4 22 3 K.DLKDYFSK.F 18066 533.2655 1064.5165 1064.5358 -0.0193 1 0 50 10 K.CEIKVAMSK.E 6446 584.2929 1166.5712 1166.5642 0.0070 0 30 0.12 1 K.FGEVVDCTLK.L 20950 26589 744.8760 1487.7374 1487.7508 -0.0133 0 68 6e-006 1 K.IFVGGLSPDTPEEK.I

191. Q15942|ZYX_HUMAN Mass: 62436 Score: 82 Queries matched: 3 emPAI: 0.06 Zyxin OS=Homo sapiens GN=ZYX PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18443 538.7881 1075.5616 1075.5662 -0.0045 0 55 0.00019 1 R.GPPASSPAPAPK.F 18447 27542 574.9333 1721.7780 1721.7647 0.0133 1 1 30 2 K.CNTCGEPITDRMLR.A

192. P05413|FABPH_HUMAN Mass: 14906 Score: 81 Queries matched: 8 emPAI: 1.01 Fatty acid-binding protein, heart OS=Homo sapiens GN=FABP3 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8191 419.7162 837.4179 837.4232 -0.0053 0 46 0.0013 1 K.NTEISFK.L 8193 11655 437.2506 872.4866 872.4967 -0.0101 0 40 0.007 1 K.NGDILTLK.T 12291 445.2466 888.4786 888.4917 -0.0131 0 30 0.069 1 K.SIVTLDGGK.L 13190 454.2432 906.4717 906.4923 -0.0206 0 35 0.02 1 K.SLGVGFATR.Q 13192 3523 13196

193. P13639|EF2_HUMAN Mass: 96246 Score: 80 Queries matched: 13 emPAI: 0.16 Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13261 456.2056 910.3967 910.4185 -0.0218 0 14 1.7 1 R.YFDPANGK.F 13700 461.7304 921.4462 921.4556 -0.0094 0 29 0.071 1 K.SDPVVSYR.E 15140 485.2673 968.5200 968.5403 -0.0204 0 40 0.005 1 R.GGGQIIPTAR.R 15139 16250 507.2442 1012.4738 1012.4938 -0.0200 0 43 0.0027 1 K.GEGQLGPAER.A 16251 16252 16254 16255 18899 546.2694 1090.5241 1090.5771 -0.0530 0 33 0.029 1 M.VNFTVDQIR.A 19407 554.3146 1106.6146 1106.6336 -0.0189 0 15 2 1 R.VFSGLVSTGLK.V 19841 562.2793 1122.5440 1122.5591 -0.0151 0 19 0.58 1 K.STLTDSLVCK.A 3734 460.2898 1377.8476 1377.7075 0.1401 0 1 2e+002 1 R.CLYASVLTAQPR.L

194. P05388|RLA0_HUMAN Mass: 34423 Score: 80 Queries matched: 10 emPAI: 0.23 60S acidic ribosomal protein P0 OS=Homo sapiens GN=RPLP0 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11762 438.2256 874.4366 874.4396 -0.0030 0 20 0.77 1 K.EDLTEIR.D 15116 484.7625 967.5105 967.5127 -0.0022 0 34 0.02 1 R.GNVGFVFTK.E 22204 609.3420 1216.6695 1216.6703 -0.0008 0 10 5.1 2 K.IIQLLDDYPK.C 22203 22205 22255 611.3083 1220.6020 1220.6149 -0.0129 0 48 0.00081 1 R.GHLENNPALEK.L 22254 22256 22258 286

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195. Q9BRF8|CPPED_HUMAN Mass: 35896 Score: 79 Queries matched: 10 emPAI: 0.22 Calcineurin-like phosphoesterase domain-containing protein 1 OS=Homo sapiens GN=CPPED1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7 400.2159 798.4172 798.4501 -0.0328 0 2 1.1e+002 5 K.FIHAGVR.V 9595 422.7645 843.5145 843.5066 0.0079 0 30 0.074 1 R.VVVVTAEK.I 9584 9588 9589 9590 9591 14512 474.2588 946.5030 946.5124 -0.0094 0 18 0.96 2 R.TLAAFPAEK.E 14490 22105 607.8353 1213.6561 1213.6666 -0.0105 0 73 2.9e-006 1 R.LTEQAVQAINK.L

196. P23396|RS3_HUMAN Mass: 26842 Score: 78 Queries matched: 15 emPAI: 0.30 40S ribosomal protein S3 OS=Homo sapiens GN=RPS3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2942 444.7480 887.4814 887.4712 0.0102 0 35 0.023 1 R.TQNVLGEK.G 12214 12232 12246 12271 16589 512.7642 1023.5139 1023.5753 -0.0614 1 4 22 9 R.KFVADGIFK.A 16588 16759 515.2572 1028.4999 1028.6230 -0.1231 0 9 6.3 2 R.TEIIILATR.T 16769 20709 578.8157 1155.6168 1155.6975 -0.0807 1 18 0.82 3 R.IRELTAVVQK.R 20707 20708 20710 20711 26079 712.3331 1422.6517 1422.6627 -0.0110 0 70 3.8e-006 1 R.ELAEDGYSGVEVR.V

197. P15153|RAC2_HUMAN Mass: 21814 Score: 78 Queries matched: 11 emPAI: 0.38 Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens GN=RAC2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14600 475.7431 949.4716 949.4869 -0.0153 0 40 0.0062 1 K.TVFDEAIR.A 14599 14601 17095 521.2727 1040.5309 1040.5437 -0.0128 0 35 0.014 1 R.AVLCPQPTR.Q 17080 17085 17098 5479 17103 5490 17787 530.7691 1059.5237 1059.5383 -0.0146 0 1 54 3 K.CVVVGDGAVGK.T

198. P25786|PSA1_HUMAN Mass: 29822 Score: 76 Queries matched: 19 emPAI: 0.43 Proteasome subunit alpha type-1 OS=Homo sapiens GN=PSMA1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7460 408.7609 815.5072 815.5116 -0.0044 0 44 0.0031 1 R.LVSLIGSK.T 7439 7448 7455 7458 7462 9553 422.2307 842.4468 842.4610 -0.0142 0 13 3.4 1 K.TQIPTQR.Y 9543 9560 9563 12161 443.7664 885.5182 885.5284 -0.0101 0 27 0.12 1 K.NVSIGIVGK.D 19391 554.2758 1106.5370 1106.6924 -0.1554 1 8 9 7 K.THAVLVALKR.A 19361 19373 19385 19393 24997 673.3449 1344.6753 1344.6773 -0.0020 0 45 0.0016 1 R.ETLPAEQDLTTK.N 24992 24996

199. P09211|GSTP1_HUMAN Mass: 23569 Score: 76 Queries matched: 6 emPAI: 0.16 Glutathione S-transferase P OS=Homo sapiens GN=GSTP1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20245 568.7809 1135.5472 1135.5696 -0.0223 0 38 0.0081 1 K.ASCLYGQLPK.F 20243 20244 20246 20247 20248

200. P30613|KPYR_HUMAN Mass: 62191 Score: 76 Queries matched: 19 emPAI: 0.06 Pyruvate kinase isozymes R/L OS=Homo sapiens GN=PKLR PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9384 421.7598 841.5050 841.4228 0.0822 0 5 19 8 K.MQHAIAR.E 9509 13511 458.7702 915.5258 915.5138 0.0120 1 16 1.6 4 R.KASDVAAVR.A 13509 13806 463.2797 924.5448 924.4665 0.0783 0 3 26 8 K.IENHEGVK.R 17223 523.2401 1044.4657 1044.4988 -0.0332 0 4 23 4 R.EAEAAVYHR.Q 17234 17286 20383 571.3040 1140.5934 1140.6026 -0.0093 0 51 0.00038 1 R.GDLGIEIPAEK.V 6353 20367 20370 20371 20375 20377 20380 20382 22525 617.2569 1232.4992 1232.6369 -0.1377 1 17 0.95 1 K.EMIKAGMNIAR.L

201. P15311|EZRI_HUMAN Mass: 69484 Score: 75 Queries matched: 29 emPAI: 0.52 Ezrin OS=Homo sapiens GN=EZR PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8066 416.2327 830.4509 830.4359 0.0151 1 10 7.9 6 R.QGNTKQR.I 8180 419.2056 836.3967 836.4028 -0.0061 0 21 0.42 1 R.NISFNDK.K 11695 437.7454 873.4762 873.4556 0.0207 1 9 8.6 7 R.AKEELER.Q 11766 438.2351 874.4556 874.4548 0.0007 0 20 0.7 1 K.ENPLQFK.F 3041 447.7733 893.5321 893.5375 -0.0054 0 10 5.1 1 K.LFFLQVK.E 12527 449.7170 897.4194 897.4192 0.0002 0 27 0.096 1 K.SGYLSSER.L 13398 457.7694 913.5242 913.5232 0.0009 0 33 0.028 1 K.IALLEEAR.R 13511 458.7702 915.5258 915.5138 0.0120 1 30 0.059 2 K.KVSAQEVR.K 13509 13539 459.2397 916.4649 916.4502 0.0147 0 25 0.2 1 K.EAQDDLVK.T 13779 462.7238 923.4330 923.4236 0.0094 0 3 26 1 R.LQDYEEK.T 14948 480.2915 958.5684 958.5851 -0.0167 0 21 0.46 1 K.FVIKPIDK.K 15062 483.2559 964.4973 964.4978 -0.0005 1 18 0.88 1 R.NISFNDKK.F 15060 4776 488.7723 975.5300 975.5389 -0.0089 0 25 0.21 1 K.QLFDQVVK.T 15577 494.2563 986.4981 986.5032 -0.0052 0 14 2.2 5 R.ALQLEEER.K 15575 15576 15995 501.7605 1001.5064 1001.5141 -0.0078 0 37 0.012 1 R.ELSEQIQR.A 16049 502.2747 1002.5348 1002.5498 -0.0150 1 22 0.37 1 R.KENPLQFK.F 18183 535.8160 1069.6175 1069.6243 -0.0069 1 10 4.8 4 K.IALLEEARR.R 18730 544.3424 1086.6703 1086.6801 -0.0098 1 35 0.018 1 K.FVIKPIDKK.A 19596 558.3001 1114.5857 1114.5982 -0.0125 1 17 1.1 2 R.ALQLEEERK.R 19613 558.7958 1115.5771 1115.5822 -0.0051 1 27 0.11 1 R.AKEAQDDLVK.T 20660 577.2800 1152.5454 1152.5662 -0.0208 1 12 3.3 1 R.LQDYEEKTK.K 6548 591.7980 1181.5814 1181.5869 -0.0055 0 38 0.0074 1 K.APDFVFYAPR.L 22676 412.8716 1235.5930 1235.5935 -0.0004 1 10 4.4 2 K.FGDYNKEVHK.S 26020 472.8959 1415.6658 1415.6640 0.0018 1 26 0.11 1 R.AQEEAERLEADR.M 26590 496.9333 1487.7780 1487.7766 0.0014 1 6 9.4 1 R.RKPDTIEVQQMK.A

202. Q99497|PARK7_HUMAN Mass: 20050 Score: 75 Queries matched: 14 emPAI: 1.40 Protein DJ-1 OS=Homo sapiens GN=PARK7 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7431 408.2453 814.4761 814.4913 -0.0151 0 41 0.0055 1 K.VTVAGLAGK.D 7424 10357 433.7592 865.5038 865.5022 0.0016 0 18 0.84 1 K.VTTHPLAK.D 10354 10356 11695 437.7454 873.4762 873.4920 -0.0158 0 31 0.062 1 K.DGLILTSR.G 11685 11703 19444 555.2355 1108.4564 1108.6241 -0.1676 1 8 6.3 8 K.VTTHPLAKDK.M 19457

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20775 579.8021 1157.5897 1157.6040 -0.0143 1 56 0.00016 1 K.EILKEQENR.K 21295 592.7999 1183.5852 1183.7289 -0.1436 1 5 18 7 R.AGIKVTVAGLAGK.D 27375 553.9375 1658.7906 1658.8185 -0.0279 1 35 0.011 1 R.DVVICPDASLEDAKK.E 27376

203. P29350|PTN6_HUMAN Mass: 67918 Score: 75 Queries matched: 53 emPAI: 0.17 Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens GN=PTPN6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6186 560.3218 559.3145 559.3442 -0.0297 1 6 48 5 K.GSLKR.K 7521 410.2391 818.4637 818.4684 -0.0047 0 6 16 7 R.VIVMTTR.E 7814 412.7508 823.4870 823.3317 0.1553 0 10 4.6 1 K.VMCEGGR.Y 7756 7758 7759 7760 7761 7765 7767 7769 7773 7774 7 13190 454.2432 906.4717 906.3930 0.0787 0 8 8.8 2 K.QESEDTAK.A 13192 15917 501.2444 1000.4742 1000.4937 -0.0196 0 54 0.00022 1 R.VNAADIENR.V 15921 15922 15932 16592 512.7799 1023.5453 1023.5462 -0.0008 0 22 0.37 1 R.VGDQVTHIR.I 5836 536.8111 1071.6077 1071.6288 -0.0211 1 7 14 4 K.KLEVLQSQK.G 19798 561.7848 1121.5550 1121.5465 0.0085 0 6 14 5 K.NQGDFSLSVR.V 21069 588.7907 1175.5669 1175.5492 0.0177 0 5 16 3 K.GLDCDIDIQK.T 21682 599.8007 1197.5869 1197.5989 -0.0121 0 30 0.045 1 K.NQLLGPDENAK.T 5310 514.3257 1539.9551 1539.8257 0.1295 0 7 25 1 R.TLQVSPLDNGDLIR.E

204. Q8TER0|SNED1_HUMAN Mass: 158206 Score: 71 Queries matched: 49 emPAI: 0.05 Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens GN=SNED1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7273 405.2108 808.4071 808.4443 -0.0372 0 36 0.015 2 K.LASYTVR.D 7269 7275 7276 7277 7278 7279 7281 7282 7283 7285 72 13624 460.2350 918.4555 918.4043 0.0512 0 37 0.014 1 R.DQATDVDR.S 13619 13620 13625 13630 13637 16453 510.2483 1018.4820 1018.4753 0.0067 0 12 3.8 5 R.EATDPAMLR.R 16445 16446 16447 16448 16450 17503 524.7104 1047.4062 1047.5560 -0.1498 1 3 26 6 K.QSKSQTLEK.S 20783 580.2751 1158.5357 1158.5815 -0.0458 1 4 21 4 R.EATDPAMLRR.A

205. P12814|ACTN1_HUMAN Mass: 103563 Score: 71 Queries matched: 16 emPAI: 0.15 Alpha-actinin-1 OS=Homo sapiens GN=ACTN1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7850 413.2288 824.4430 824.4392 0.0038 0 29 0.067 1 R.LDHLAEK.F 7848 7849 8017 415.7013 829.3880 829.4181 -0.0301 0 3 43 3 K.ATLPDADK.E 14567 474.7728 947.5310 947.5440 -0.0130 0 20 0.58 1 K.SIVNYKPK.I 14552 14562 15759 497.2258 992.4369 992.4464 -0.0095 0 24 0.21 1 R.ASFNHFDR.D 19577 558.2697 1114.5249 1114.5618 -0.0369 1 25 0.18 1 K.ATLPDADKER.L 19586 22404 409.8819 1226.6239 1226.6407 -0.0169 0 14 2 1 R.HRPELIDYGK.L 24577 442.5578 1324.6516 1324.6483 0.0032 1 46 0.0011 1 R.RDQALTEEHAR.Q 24576 24579 24582 25663 693.8306 1385.6466 1385.7667 -0.1201 0 7 10 7 R.VGWEQLLTTIAR.T

206. P18085|ARF4_HUMAN Mass: 20612 Score: 70 Queries matched: 7 emPAI: 0.41 ADP-ribosylation factor 4 OS=Homo sapiens GN=ARF4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5967 544.3026 1086.5907 1086.6107 -0.0200 0 (32) 0.12 1 R.ILMVGLDAAGK.T 18727 19220 552.3061 1102.5977 1102.6056 -0.0079 0 45 0.0018 1 R.ILMVGLDAAGK.T 19215 19219 19221 6484 586.7820 1171.5494 1171.6084 -0.0591 0 10 5.3 5 R.IQEVADELQK.M

207. Q9UJ70|NAGK_HUMAN Mass: 37694 Score: 69 Queries matched: 7 emPAI: 0.33 N-acetyl-D-glucosamine kinase OS=Homo sapiens GN=NAGK PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12113 443.2730 884.5315 884.5331 -0.0016 0 26 0.14 1 R.ILIEELR.D 2879 17000 518.8065 1035.5983 1035.6077 -0.0093 0 41 0.0047 1 K.AGVDPLVPLR.S 18355 537.7747 1073.5348 1073.5651 -0.0304 1 4 24 3 R.INEMVNRAK.R 5946 543.3030 1084.5915 1084.6393 -0.0478 0 7 30 1 R.LGILTHLYR.D 21064 588.3076 1174.6006 1174.6081 -0.0075 0 41 0.0044 1 R.SEVLLVSEDGK.I 24905 671.3308 1340.6470 1340.6684 -0.0215 0 34 0.02 1 K.IAEGAQQGDPLSR.Y

208. Q14344|GNA13_HUMAN Mass: 44364 Score: 69 Queries matched: 23 emPAI: 0.08 Guanine nucleotide-binding protein subunit alpha-13 OS=Homo sapiens GN=GNA13 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9661 424.2242 846.4339 846.4334 0.0005 0 13 3 4 K.TDLLEEK.V 9653 9654 9658 9660 9665 9666 1435 14185 468.7330 935.4515 935.4535 -0.0020 0 15 1.8 1 -.MADFLPSR.S 16335 508.7655 1015.5165 1015.5597 -0.0432 1 13 3.1 3 K.GMRVLVDAR.E 16329 16331 16332 16333 16334 17701 529.3150 1056.6155 1056.6179 -0.0024 0 48 0.0008 1 K.ILLLGAGESGK.S 17687 5687 17699 17700 22909 625.3095 1248.6045 1248.5881 0.0165 1 7 8.7 3 K.MVDVGGQRSER.K 22908 22910

209. Q03113|GNA12_HUMAN Mass: 44422 Score: 69 Queries matched: 9 emPAI: 0.08 Guanine nucleotide-binding protein subunit alpha-12 OS=Homo sapiens GN=GNA12 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10249 432.1742 862.3338 862.4470 -0.1132 0 13 3.5 1 K.MDLLVEK.V 14792 478.7603 955.5061 955.5814 -0.0753 1 21 0.41 1 K.QDILLARK.A 14783 17701 529.3150 1056.6155 1056.6179 -0.0024 0 48 0.0008 1 K.ILLLGAGESGK.S 17687 5687 17699 17700 19750 561.2890 1120.5634 1120.6023 -0.0389 1 2 33 8 -.MSGVVRTLSR.C

210. P38405|GNAL_HUMAN Mass: 44794 Score: 69 Queries matched: 17 emPAI: 0.08 Guanine nucleotide-binding protein G(olf) subunit alpha OS=Homo sapiens GN=GNAL PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1492 425.2819 848.5493 848.4240 0.1254 0 3 79 1 R.ISTATGDGK.H 17701 529.3150 1056.6155 1056.6179 -0.0024 0 48 0.0008 1 R.LLLLGAGESGK.S 17687 5687 17699 17700 18797 545.2758 1088.5371 1088.5502 -0.0131 1 9 6.7 5 K.KLWDDEGVK.A 18784 18853 20827 581.2955 1160.5764 1160.7169 -0.1405 0 11 4.6 3 R.TISIILFLNK.Q 20826 20828 20829 20830 20831 20832 6834 651.8131 1301.6117 1301.7013 -0.0896 1 4 17 6 K.QDMLAEKVLAGK.S

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211. P04899|GNAI2_HUMAN Mass: 40995 Score: 69 Queries matched: 7 emPAI: 0.09 Guanine nucleotide-binding protein G(i), alpha-2 subunit OS=Homo sapiens GN=GNAI2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12951 453.2349 904.4552 904.4800 -0.0248 1 7 14 1 K.MIDKNLR.E 12968 17701 529.3150 1056.6155 1056.6179 -0.0024 0 48 0.0008 1 K.LLLLGAGESGK.S 17687 5687 17699 17700

212. P11488|GNAT1_HUMAN Mass: 40471 Score: 69 Queries matched: 8 emPAI: 0.09 Guanine nucleotide-binding protein G(t) subunit alpha-1 OS=Homo sapiens GN=GNAT1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3908 467.1361 932.2577 932.4199 -0.1622 1 3 16 1 K.EDAEKDAR.T 3911 4233 475.7497 949.4849 949.4175 0.0674 0 1 43 8 -.MGAGASAEEK.H 17701 529.3150 1056.6155 1056.6179 -0.0024 0 48 0.0008 1 K.LLLLGAGESGK.S 17687 5687 17699 17700

213. Q8N1A0|KT222_HUMAN Mass: 34308 Score: 69 Queries matched: 3 emPAI: 0.11 Keratin-like protein KRT222 OS=Homo sapiens GN=KRT222 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19798 561.7848 1121.5550 1121.5717 -0.0166 0 53 0.00026 1 R.LEQEIATYR.H 19797 4688 486.9521 1457.8345 1457.7184 0.1161 0 3 21 1 R.SCSIPSIKPPSTAN.-

214. P19338|NUCL_HUMAN Mass: 76625 Score: 68 Queries matched: 34 emPAI: 0.10 Nucleolin OS=Homo sapiens GN=NCL PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6847 658.3235 657.3162 657.3810 -0.0648 1 12 4.6 4 K.KGATPGK.A 7065 401.2239 800.4333 800.4756 -0.0423 1 10 6.6 2 K.AVTTPGKK.G 7327 406.2149 810.4152 810.5327 -0.1175 1 3 24 2 K.AAKVVPVK.A 9587 422.7497 843.4848 843.5065 -0.0217 0 18 1 1 K.ALELTGLK.V 12028 442.7546 883.4947 883.5491 -0.0544 1 17 0.9 1 K.VAVATPAKK.A 12020 2839 12022 12024 12025 12029 12030 12031 12 13412 457.7783 913.5420 913.4617 0.0803 1 1 46 3 K.AGKNQGDPK.K 14205 469.2466 936.4786 936.4917 -0.0131 0 37 0.01 1 K.TGISDVFAK.N 14207 14208 14210 14212 4108 472.2461 942.4777 942.5246 -0.0470 1 7 30 3 R.EIEGRAIR.L 15900 500.7653 999.5160 999.5349 -0.0189 0 46 0.0015 1 K.NDLAVVDVR.I 15898 15901 18892 546.2487 1090.4828 1090.5189 -0.0361 1 5 16 2 K.EALNSCNKR.E 19128 550.2293 1098.4441 1098.5782 -0.1340 1 0 44 1 K.VPQNQNGKSK.G

215. P35579|MYH9_HUMAN Mass: 227646 Score: 68 Queries matched: 37 emPAI: 0.08 Myosin-9 OS=Homo sapiens GN=MYH9 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7063 401.2205 800.4265 800.4756 -0.0490 1 15 2.6 2 R.VKANLEK.A 7070 401.2403 800.4660 800.4140 0.0520 0 6 17 5 K.QLAAENR.L 7251 404.7310 807.4474 807.4491 -0.0016 0 7 11 1 R.TVGQLYK.E 7247 8043 415.7397 829.4649 829.4545 0.0104 0 28 0.11 1 K.GALALEEK.R 8034 8228 420.2292 838.4439 838.4007 0.0433 0 8 7.6 5 R.NCAAYLK.L 8222 12291 445.2466 888.4786 888.5644 -0.0858 1 11 5.7 10 K.LSLSTKLK.Q 12519 449.2673 896.5200 896.5807 -0.0607 1 7 9.9 5 R.GILTPRIK.V 12695 451.2388 900.4630 900.4916 -0.0286 0 2 43 3 R.EEILAQAK.E 12871 452.2623 902.5100 902.5073 0.0028 0 33 0.03 1 K.ASITALEAK.I 12878 452.2680 902.5214 902.4345 0.0869 0 0 62 8 R.VEEEAAQK.N 13533 459.2294 916.4442 916.4362 0.0080 1 5 20 4 R.DRAEAEAR.E 13537 459.2366 916.4586 916.4614 -0.0027 0 15 2.3 2 K.DLEGLSQR.H 13535 13783 462.7522 923.4899 923.4865 0.0034 0 44 0.0018 1 R.VVFQEFR.Q 4188 474.2670 946.5194 946.4971 0.0223 1 2 1.5e+002 2 K.KTLEEEAK.T 14997 481.2354 960.4562 960.4777 -0.0215 0 8 9.7 2 R.NTNPNFVR.C 15174 486.7513 971.4881 971.5399 -0.0518 1 7 12 9 K.AELERLNK.Q 15182 486.7733 971.5320 971.5287 0.0033 0 11 5.2 8 R.EQEVNILK.K 15565 493.7898 985.5650 985.5556 0.0094 1 24 0.22 1 K.GALALEEKR.R 15564 15891 500.2697 998.5249 998.5549 -0.0300 0 5 18 3 R.GDLPFVVPR.R 16073 502.7861 1003.5577 1003.5550 0.0027 1 13 3 2 R.TELADKVTK.L 5104 503.2505 1004.4864 1004.5185 -0.0321 1 6 78 1 K.QRSMAVAAR.K 16343 509.2553 1016.4960 1016.5073 -0.0113 0 1 48 9 R.CNGVLEGIR.I 17240 523.2703 1044.5260 1044.5637 -0.0377 0 8 9.4 3 R.LEVNLQAMK.A 17233 17270 18774 544.7995 1087.5844 1087.5621 0.0222 1 1 48 6 K.AKQTLENER.G 19156 550.7538 1099.4930 1099.6237 -0.1307 1 1 46 9 R.EQEVNILKK.T 21410 597.3155 1192.6164 1192.6088 0.0077 0 26 0.12 1 K.ALELDSNLYR.I 21817 603.3160 1204.6173 1204.6339 -0.0166 0 38 0.0085 1 K.TDLLLEPYNK.Y 23088 629.3453 1256.6760 1256.6724 0.0036 1 27 0.099 1 K.KEEELQAALAR.V 2917 444.2461 1329.7164 1329.7438 -0.0275 1 1 2.2e+002 9 K.LRLEVNLQAMK.A 24686 666.3004 1330.5863 1330.6000 -0.0137 0 18 0.71 1 R.QLEEAEEEAQR.A

216. P54819|KAD2_HUMAN Mass: 26689 Score: 67 Queries matched: 7 emPAI: 0.14 Adenylate kinase 2, mitochondrial OS=Homo sapiens GN=AK2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13183 454.2233 906.4321 906.5399 -0.1078 1 4 27 6 R.LIHPKSGR.S 15276 487.7534 973.4921 973.4902 0.0019 0 25 0.23 1 K.NLETPLCK.N 15441 490.2955 978.5765 978.5862 -0.0097 0 50 0.00059 1 R.AVLLGPPGAGK.G 15438 15439 15440 20007 564.7717 1127.5289 1127.5822 -0.0533 0 3 31 5 K.DDITGEPLIR.R

217. P62873|GBB1_HUMAN Mass: 38151 Score: 67 Queries matched: 6 emPAI: 0.33 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens GN=GNB1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7142 403.2564 804.4983 804.4970 0.0013 0 25 0.22 1 K.VHAIPLR.S 16162 504.2741 1006.5337 1006.4753 0.0584 0 27 0.11 2 -.MSELDQLR.Q 16189 505.2591 1008.5037 1008.5101 -0.0063 0 43 0.0026 1 R.AGVLAGHDNR.V 16191 16360 509.2798 1016.5451 1016.5502 -0.0051 0 34 0.026 1 R.LLVSASQDGK.L 16359

218. P62942|FKB1A_HUMAN Mass: 12000 Score: 67 Queries matched: 2 emPAI: 0.33

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Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens GN=FKBP1A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 24409 657.8208 1313.6270 1313.6576 -0.0305 0 67 9.2e-006 1 M.GVQVETISPGDGR.T 26931 517.2771 1548.8094 1548.6991 0.1103 0 1 33 2 R.GWEEGVAQMSVGQR.A

219. P47929|LEG7_HUMAN Mass: 15123 Score: 67 Queries matched: 2 emPAI: 0.26 Galectin-7 OS=Homo sapiens GN=LGALS7 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13258 455.7448 909.4751 909.5032 -0.0281 0 11 3.7 3 R.GLVPPNASR.F 22696 619.7995 1237.5845 1237.6190 -0.0345 0 67 9e-006 1 R.LDTSEVVFNSK.E

220. P05107|ITB2_HUMAN Mass: 87976 Score: 67 Queries matched: 14 emPAI: 0.09 Integrin beta-2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11562 436.2592 870.5039 870.5287 -0.0248 1 8 11 5 K.KLGGDLLR.A 2490 2526 2541 17486 524.2372 1046.4599 1046.4815 -0.0216 0 50 0.00061 1 R.TTEGCLNPR.R 17484 18791 545.2655 1088.5164 1088.5462 -0.0297 0 31 0.051 1 R.ALNEITESGR.I 18781 18782 18784 18790 18799 19956 563.7541 1125.4937 1125.6142 -0.1205 0 5 14 1 K.LGAILTPNDGR.C 24201 435.8950 1304.6632 1304.6329 0.0303 0 1 40 5 R.CDTRPQLLMR.G

221. P29692|EF1D_HUMAN Mass: 31217 Score: 66 Queries matched: 3 emPAI: 0.12 Elongation factor 1-delta OS=Homo sapiens GN=EEF1D PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15263 487.2952 972.5759 972.5757 0.0002 0 14 2.5 1 K.LVPVGYGIR.K 15256 25232 679.8540 1357.6934 1357.7201 -0.0267 0 66 1.1e-005 1 R.IASLEVENQSLR.G

222. P30044|PRDX5_HUMAN Mass: 22298 Score: 66 Queries matched: 5 emPAI: 0.17 Peroxiredoxin-5, mitochondrial OS=Homo sapiens GN=PRDX5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18805 545.2944 1088.5742 1088.5866 -0.0124 0 44 0.0025 1 R.LLADPTGAFGK.E 18797 18802 18804 18806

223. Q9NSB4|KRT82_HUMAN Mass: 57985 Score: 66 Queries matched: 46 emPAI: 0.06 Keratin, type II cuticular Hb2 OS=Homo sapiens GN=KRT82 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13103 453.7355 905.4564 905.4970 -0.0406 1 40 0.0058 1 R.FLEQKNK.L 13068 13069 13070 13071 13072 13073 13075 13076 130 15795 497.7574 993.5002 993.4623 0.0378 0 5 16 4 K.QDMACLLK.E 17036 519.7372 1037.4597 1037.4778 -0.0180 0 3 27 5 K.AQYDDIASR.S 21280 592.3969 1182.7793 1182.5955 0.1839 1 2 17 1 K.KDVDTAFLM K.A 23156 631.7893 1261.5639 1261.6350 -0.0710 0 6 13 8 R.SLCNVGFGRPR.V 2072 432.8805 1295.6196 1295.5717 0.0479 0 4 19 2 -.MSYHSFQPGSR.C 1976 2004

224. P62993|GRB2_HUMAN Mass: 25304 Score: 65 Queries matched: 10 emPAI: 0.52 Growth factor receptor-bound protein 2 OS=Homo sapiens GN=GRB2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7614 412.2145 822.4143 822.3793 0.0351 0 14 2.1 2 K.AEEMLSK.Q 7598 7607 13577 459.7529 917.4912 917.5083 -0.0171 0 29 0.077 1 R.NQQIFLR.D 3699 15015 481.7470 961.4794 961.4981 -0.0187 0 23 0.3 1 R.NYVTPVNR.N 19070 548.7502 1095.4858 1095.5084 -0.0226 0 49 0.00065 1 K.ATADDELSFK.R 19371 554.2602 1106.5059 1106.5390 -0.0331 1 23 0.26 1 K.AEEMLSKQR.H 19381 26321 726.8292 1451.6439 1451.6780 -0.0341 0 36 0.01 1 R.ESESAPGDFSLSVK.F

225. Q15121|PEA15_HUMAN Mass: 15088 Score: 65 Queries matched: 3 emPAI: 0.26 Astrocytic phosphoprotein PEA-15 OS=Homo sapiens GN=PEA15 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7225 404.2149 806.4152 806.4650 -0.0498 1 6 15 2 K.YKDIIR.Q 21165 589.7705 1177.5264 1177.5350 -0.0086 0 65 1.9e-005 1 K.ISEEDELDTK.L 21166

226. P00491|PNPH_HUMAN Mass: 32325 Score: 64 Queries matched: 2 emPAI: 0.12 Purine nucleoside phosphorylase OS=Homo sapiens GN=NP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20301 569.7905 1137.5665 1137.5778 -0.0113 0 48 0.00079 1 K.ANHEEVLAAGK.Q 20302

227. P30086|PEBP1_HUMAN Mass: 21158 Score: 63 Queries matched: 10 emPAI: 0.39 Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens GN=PEBP1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6355 571.2890 570.2817 570.2510 0.0307 0 1 30 1 R.SGDHR.G 12103 443.2641 884.5136 884.5331 -0.0195 0 25 0.18 1 K.VLTPTQVK.N 12071 12104 12105 12107 14201 469.2436 936.4726 936.4916 -0.0190 0 40 0.0053 1 K.LYEQLSGK.- 14198 14202 14204

228. P04839|CY24B_HUMAN Mass: 66206 Score: 63 Queries matched: 5 emPAI: 0.06 Cytochrome b-245 heavy chain OS=Homo sapiens GN=CYBB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7967 414.2438 826.4731 826.4701 0.0029 0 15 1.5 1 K.VVTHPFK.T 7946 19079 549.2445 1096.4745 1096.4971 -0.0226 0 11 3.9 1 K.YCNNATNLK.L 19899 562.7803 1123.5460 1123.5734 -0.0274 0 51 0.00042 1 K.TIASQHPNTR.I 19900

229. Q13835|PKP1_HUMAN Mass: 84119 Score: 63 Queries matched: 10 emPAI: 0.09 Plakophilin-1 OS=Homo sapiens GN=PKP1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12648 450.7371 899.4596 899.4712 -0.0117 0 46 0.0013 1 R.LDAEVPTR.Y 16336 508.7702 1015.5258 1015.5410 -0.0152 1 15 2 4 R.RTGNAEIQK.Q 16330 17534 525.2745 1048.5344 1048.5513 -0.0169 1 7 11 1 R.STTNKLETR.R

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20473 573.2738 1144.5330 1144.5836 -0.0506 1 3 25 4 R.SSASPKAAEAAR.L 21344 594.3108 1186.6071 1186.6306 -0.0235 0 47 0.0012 1 R.LLQSGNSDVVR.S 21345 21925 604.8008 1207.5870 1207.5941 -0.0071 0 6 13 10 R.VQEQVMMTVK.R 26332 727.3577 1452.7009 1452.7316 -0.0307 0 5 14 2 K.GLM SSGMSQLIGLK.E 26977 522.5490 1564.6251 1564.6940 -0.0689 1 0 28 4 K.ASRSEPDLYCDPR.G

230. O00175|CCL24_HUMAN Mass: 13467 Score: 63 Queries matched: 5 emPAI: 0.29 C-C motif chemokine 24 OS=Homo sapiens GN=CCL24 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4696 487.2372 486.2299 486.3166 -0.0867 0 1 1.8e+002 3 R.AVAVK.G 6158 558.3039 557.2967 557.3285 -0.0319 1 6 39 2 K.KASPR.A 17044 519.7699 1037.5252 1037.5506 -0.0253 0 55 0.00015 1 R.VVSYQLSSR.S 17045 27325 412.7459 1646.9543 1646.8740 0.0803 1 0 33 1 R.IPENRVVSYQLSSR.S

231. O95336|6PGL_HUMAN Mass: 27815 Score: 63 Queries matched: 9 emPAI: 0.29 6-phosphogluconolactonase OS=Homo sapiens GN=PGLS PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14484 473.7737 945.5328 945.5535 -0.0207 0 34 0.028 1 R.LLTVPFEK.H 19773 561.3107 1120.6069 1120.6128 -0.0059 0 41 0.0046 1 R.TVIFVATGEGK.A 19702 19764 19765 19767 19768 19771 27171 534.6440 1600.9102 1600.8937 0.0165 0 7 7.1 1 K.IVAPISDSPKPPPQR.V

232. P39019|RS19_HUMAN Mass: 16051 Score: 62 Queries matched: 3 emPAI: 0.24 40S ribosomal protein S19 OS=Homo sapiens GN=RPS19 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18180 535.8099 1069.6052 1069.6244 -0.0192 1 4 22 10 R.IAGQVAAANKK.H 20203 567.7716 1133.5285 1133.5465 -0.0180 0 45 0.0016 1 K.DVNQQEFVR.A 20198

233. P22314|UBA1_HUMAN Mass: 118858 Score: 62 Queries matched: 9 emPAI: 0.10 Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1536 426.7441 851.4737 851.4059 0.0679 0 2 36 6 -.MSSSPLSK.K 1541 14005 466.2392 930.4637 930.5208 -0.0571 0 4 24 3 K.SIPICTLK.N 16384 509.7249 1017.4353 1017.4451 -0.0098 0 32 0.036 1 R.VGEFCHNR.G 19191 551.8053 1101.5961 1101.6142 -0.0181 1 34 0.024 1 K.LKSDTAAAAVR.Q 22938 625.7793 1249.5441 1249.5575 -0.0134 0 51 0.00042 1 R.AENYDIPSADR.H 22939 23102 420.5552 1258.6438 1258.7245 -0.0807 0 3 23 9 R.LQTSSVLVSGLR.G 23749 644.8324 1287.6503 1287.6493 0.0010 0 20 0.47 3 R.LDQPMTEIVSR.V

234. P60903|S10AA_HUMAN Mass: 11310 Score: 61 Queries matched: 3 emPAI: 0.35 Protein S100-A10 OS=Homo sapiens GN=S100A10 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19152 550.2815 1098.5485 1098.5710 -0.0225 1 49 0.00066 1 K.FAGDKGYLTK.E 19141 19144

235. P39687|AN32A_HUMAN Mass: 28682 Score: 61 Queries matched: 5 emPAI: 0.28 Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens GN=ANP32A PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14446 473.2542 944.4939 944.4927 0.0012 0 19 0.96 1 K.ELVLDNSR.S 16321 508.2886 1014.5626 1014.5597 0.0029 0 22 0.38 1 K.DLSTIEPLK.K 16319 19178 551.3120 1100.6094 1100.6077 0.0017 0 60 5.6e-005 1 R.VSGGLEVLAEK.C 19176

236. Q9NRV9|HEBP1_HUMAN Mass: 21198 Score: 61 Queries matched: 2 emPAI: 0.18 Heme-binding protein 1 OS=Homo sapiens GN=HEBP1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16334 508.7630 1015.5114 1015.5702 -0.0588 1 0 57 8 R.NEIWLLKT.- 19829 562.2587 1122.5028 1122.5305 -0.0277 0 61 3.7e-005 1 K.EADYVAQATR.L

237. P20962|PTMS_HUMAN Mass: 11523 Score: 61 Queries matched: 8 emPAI: 0.34 Parathymosin OS=Homo sapiens GN=PTMS PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6830 649.3764 648.3691 648.2715 0.0977 0 1 48 1 K.TENGASA.- 13019 453.2651 904.5156 904.4250 0.0906 1 10 6.4 4 R.QKTENGASA.- 3393 13013 3450 13060 18401 538.2806 1074.5467 1074.5557 -0.0090 0 51 0.0005 1 K.SVEAAAELSAK.D 18396

238. Q7Z6K2|TPISL_HUMAN Mass: 25016 Score: 61 Queries matched: 13 emPAI: 0.15 Putative triosephosphate isomerase-like protein LOC286016 OS=Homo sapiens PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9746 425.7316 849.4486 849.4596 -0.0110 0 22 0.45 1 K.VVFEQTK.V 9745 9748 9750 9751 9753 9760 12956 453.2366 904.4587 904.4337 0.0250 1 5 21 7 R.NWKMNGR.K 3453 13693 461.2401 920.4656 920.4286 0.0369 1 (0) 54 1 R.NWKMNGR.K 23133 630.7952 1259.5758 1259.6357 -0.0599 1 8 7.5 2 K.LDEREAGITEK.V 23472 637.8346 1273.6546 1273.6666 -0.0121 1 61 4.2e-005 1 K.VIADNVKDWSK.V 24779 446.5611 1336.6614 1336.6735 -0.0121 0 0 42 3 K.TATPQQAQEVHK.K

239. P60763|RAC3_HUMAN Mass: 21764 Score: 61 Queries matched: 8 emPAI: 0.38 Ras-related C3 botulinum toxin substrate 3 OS=Homo sapiens GN=RAC3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14600 475.7431 949.4716 949.4869 -0.0153 0 40 0.0062 1 K.TVFDEAIR.A 14599 14601 15460 490.7737 979.5328 979.5525 -0.0196 0 33 0.024 1 R.AVLCPPPVK.K 15457 15458 15459 17787 530.7691 1059.5237 1059.5383 -0.0146 0 1 54 3 K.CVVVGDGAVGK.T

Proteins matching the same set of peptides: P63000|RAC1_HUMAN Mass: 21835 Score: 61 Queries matched: 8

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Ras-related C3 botulinum toxin substrate 1 OS=Homo sapiens GN=RAC1 PE=1 SV=1

240. P38646|GRP75_HUMAN Mass: 73920 Score: 61 Queries matched: 6 emPAI: 0.10 Stress-70 protein, mitochondrial OS=Homo sapiens GN=HSPA9 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1759 431.6922 861.3697 861.4444 -0.0746 0 0 64 2 R.ETGVDLTK.D 19193 551.8100 1101.6055 1101.5713 0.0342 1 2 38 5 K.DNMALQRVR.E 19831 562.2615 1122.5085 1122.4789 0.0296 0 4 21 5 R.EGSGSSGTGEQK.E 19812 20538 575.2747 1148.5348 1148.5462 -0.0114 1 28 0.082 1 R.RYDDPEVQK.D 26313 725.8572 1449.6999 1449.7100 -0.0101 0 54 0.00018 1 R.TTPSVVAFTADGER.L

241. P09327|VILI_HUMAN Mass: 93093 Score: 60 Queries matched: 13 emPAI: 0.04 Villin-1 OS=Homo sapiens GN=VIL1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7386 407.2506 812.4867 812.5232 -0.0365 1 11 3.7 3 K.QGLVIRK.G 279 9764 425.7495 849.4845 849.4378 0.0467 1 39 0.0087 1 R.KGGVASGMK.H 9741 9749 9758 9761 9762 9763 12618 450.2654 898.5162 898.4872 0.0289 0 2 32 1 K.THTVGSVAK.V 13664 460.7298 919.4451 919.4875 -0.0424 1 2 40 4 K.APYANTKR.L 24133 434.8838 1301.6295 1301.6472 -0.0177 0 0 44 1 K.LMEVMNHVLGK.R 24449 658.8206 1315.6267 1315.7070 -0.0803 1 1 40 10 K.KGAMSHALNFIK.A

242. O76011|KRT34_HUMAN Mass: 50818 Score: 60 Queries matched: 19 emPAI: 0.15 Keratin, type I cuticular Ha4 OS=Homo sapiens GN=KRT34 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7624 412.2228 822.4310 822.3872 0.0439 0 20 0.51 1 K.LASDDFR.S 465 7597 7600 7639 7634 412.2241 822.4336 822.4487 -0.0151 0 48 0.00089 1 R.LASYLEK.V 7631 7638 7649 15545 493.2948 984.5750 984.5604 0.0146 0 15 1.8 2 R.LVVNIDNAK.L 15544 15546 15548 15635 494.7690 987.5235 987.5237 -0.0002 0 29 0.081 1 K.TIEELQQK.I 15631 18502 539.7557 1077.4968 1077.6182 -0.1214 1 5 17 7 R.LASYLEKVR.Q 20487 573.3010 1144.5875 1144.6022 -0.0148 1 2 31 9 K.ILCAKAENAR.L 20486 23184 631.8028 1261.5910 1261.6150 -0.0240 0 4 19 4 K.SDLESQVESLR.E

243. Q9NQC3|RTN4_HUMAN Mass: 130250 Score: 60 Queries matched: 30 emPAI: 0.03 Reticulon-4 OS=Homo sapiens GN=RTN4 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11575 436.7360 871.4575 871.4586 -0.0011 0 14 2.9 2 R.VAVEAPMR.E 11576 11577 11580 11581 11585 11586 11587 11590 1 12238 444.7368 887.4590 887.4535 0.0055 0 (11) 5.4 5 R.VAVEAPMR.E 12228 12230 12248 12255 12263 12264 12276 17265 523.2750 1044.5354 1044.4764 0.0591 0 6 14 9 K.ISFSDDFSK.N 17239 17286 17321 23448 636.3491 1270.6836 1270.7034 -0.0197 0 50 0.00047 1 R.GPLPAAPPVAPER.Q 23440 23443 23449 24484 660.3479 1318.6813 1318.7092 -0.0279 1 11 4.3 2 K.AQIVTEKNTSTK.T 24482 24483

244. O94903|PROSC_HUMAN Mass: 30610 Score: 59 Queries matched: 4 emPAI: 0.12 Proline synthetase co-transcribed bacterial homolog protein OS=Homo sapiens GN=PROSC PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15785 497.2545 992.4944 992.4927 0.0017 0 59 7.1e-005 1 K.APLEVAQEH.- 24676 665.3445 1328.6745 1328.6758 -0.0013 1 2 32 4 K.KPTPDKCAADVK.A 24844 670.8239 1339.6332 1339.7320 -0.0988 1 6 12 4 R.AVNERVQQAVAR.R 26651 498.9036 1493.6888 1493.6966 -0.0078 0 0 38 2 R.AGSMSAELGVGCALR.A

245. P22626|ROA2_HUMAN Mass: 37464 Score: 58 Queries matched: 8 emPAI: 0.21 Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens GN=HNRNPA2B1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16247 507.2257 1012.4369 1012.4363 0.0006 0 32 0.027 1 R.GGNFGFGDSR.G 16246 16249 17693 529.2848 1056.5550 1056.5815 -0.0265 0 15 1.7 1 K.TLETVPLER.K 20903 583.2291 1164.4437 1164.5159 -0.0723 0 7 8.7 3 K.EDTEEHHLR.D 25554 689.3139 1376.6132 1376.6222 -0.0090 0 44 0.0017 1 R.GGGGNFGPGPGSNFR.G 26780 761.3455 1520.6764 1520.7001 -0.0237 1 4 16 5 R.QEMQEVQSSRSGR.G 26782

246. Q9UK45|LSM7_HUMAN Mass: 11709 Score: 58 Queries matched: 1 emPAI: 0.34 U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens GN=LSM7 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12921 452.7448 903.4749 903.4913 -0.0163 0 58 0.00011 1 K.ESILDLSK.Y

247. Q6A162|K1C40_HUMAN Mass: 50046 Score: 57 Queries matched: 45 emPAI: 0.07 Keratin, type I cytoskeletal 40 OS=Homo sapiens GN=KRT40 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7304 405.2237 808.4328 808.3967 0.0362 0 13 2.9 1 K.LATDDFK.S 7273 7275 7276 7277 7278 7279 7281 7282 7283 7285 7634 412.2241 822.4336 822.4487 -0.0151 0 48 0.00089 1 R.LASYLEK.V 7600 7624 7631 7638 7639 7649 18502 539.7557 1077.4968 1077.6182 -0.1214 1 5 17 7 R.LASYLEKVR.S 21963 606.2392 1210.4638 1210.6193 -0.1555 1 4 11 3 K.SKYESELSLR.Q 957 418.1983 1251.5730 1251.6207 -0.0477 0 4 1.2e+002 1 K.NHEEEVNLLR.E 954 25576 460.8906 1379.6498 1379.7157 -0.0659 1 8 7.6 1 K.KNHEEEVNLLR.E

248. Q9C075|K1C23_HUMAN Mass: 48272 Score: 57 Queries matched: 10 emPAI: 0.08 Keratin, type I cytoskeletal 23 OS=Homo sapiens GN=KRT23 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7634 412.2241 822.4336 822.4487 -0.0151 0 48 0.00089 1 R.LASYLEK.V 7600 7624 7631 7638 7639 7649 12983 453.2528 904.4911 904.4324 0.0587 0 3 29 1 R.ALEEANMK.L 16958 518.2888 1034.5631 1034.5648 -0.0016 0 3 29 6 R.QEYELIIK.K 18502 539.7557 1077.4968 1077.6182 -0.1214 1 5 17 7 R.LASYLEKVR.A

249. P02452|CO1A1_HUMAN Mass: 139853 Score: 57 Queries matched: 10 emPAI: 0.05 Collagen alpha-1(I) chain OS=Homo sapiens GN=COL1A1 PE=1 SV=4

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5706 530.2709 529.2636 529.2609 0.0027 0 2 1.1e+002 3 R.GGPGSR.G 9783 426.2104 850.4063 850.4185 -0.0122 0 29 0.059 1 R.GFSGLDGAK.G 9782 13287 456.7467 911.4789 911.4573 0.0216 1 3 22 7 K.GDTGPRGPR.G 22060 607.3002 1212.5858 1212.5735 0.0123 1 12 3.1 2 R.GDAGPKGADGSPGK.D 22059 22061 22063 22064 27971 654.6515 1960.9326 1960.9715 -0.0389 1 44 0.0012 1 K.SGDRGETGPAGPAGPVGPVGAR.G

250. P31146|COR1A_HUMAN Mass: 51678 Score: 56 Queries matched: 11 emPAI: 0.23 Coronin-1A OS=Homo sapiens GN=CORO1A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7433 408.2476 814.4807 814.4661 0.0146 1 6 17 9 K.RGLEVNK.C 8176 418.7261 835.4377 835.4440 -0.0063 0 27 0.12 1 R.AVFVSEGK.I 11947 441.7208 881.4271 881.5447 -0.1175 1 0 46 8 R.VRIIEPR.K 11983 442.2375 882.4605 882.4712 -0.0107 0 19 0.6 1 R.HVFGQPAK.A 11988 14966 480.7507 959.4867 959.5076 -0.0209 0 0 61 9 R.QVALWDTK.H 16681 513.8099 1025.6052 1025.6121 -0.0069 0 35 0.014 1 R.DAGPLLISLK.D 16676 23744 430.1992 1287.5759 1287.6605 -0.0846 1 1 40 9 R.GLEVNKCEIAR.F 26684 751.8544 1501.6943 1501.7009 -0.0065 0 35 0.014 1 R.AAPEASGTPSSDAVSR.L 26683

251. P27695|APEX1_HUMAN Mass: 35931 Score: 56 Queries matched: 2 emPAI: 0.10 DNA-(apurinic or apyrimidinic site) lyase OS=Homo sapiens GN=APEX1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16458 510.2527 1018.4909 1018.4832 0.0077 0 48 0.001 1 K.NAGFTPQER.Q 16456

252. P15586|GNS_HUMAN Mass: 62840 Score: 56 Queries matched: 2 emPAI: 0.06 N-acetylglucosamine-6-sulfatase OS=Homo sapiens GN=GNS PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12921 452.7448 903.4749 903.4563 0.0187 0 2 37 8 R.GASNLTWR.S 5640 525.2761 1048.5376 1048.5454 -0.0078 0 56 0.00035 1 K.AFQNVFAPR.N

253. Q8WZ42|TITIN_HUMAN Mass: 3843119 Score: 55 Queries matched: 290 emPAI: 0.00 Titin OS=Homo sapiens GN=TTN PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4798 489.2802 488.2729 488.2958 -0.0229 0 9 19 1 R.ISAAK.V 5293 513.2381 512.2308 512.2707 -0.0399 0 7 25 1 K.THAGK.Y 5383 517.2588 516.2515 516.2908 -0.0393 0 7 53 8 K.VDVGK.K 5415 518.2848 517.2775 517.2860 -0.0085 1 3 51 1 K.ADGKK.R 5777 533.2633 532.2560 532.3221 -0.0660 0 2 74 1 K.SVSLK.W 5794 534.2792 533.2719 533.2445 0.0274 0 1 55 1 R.NDTGK.Y 5948 543.3098 542.3025 542.3540 -0.0515 0 8 23 5 K.GIVVR.A 5949 6029 547.3221 546.3148 546.3013 0.0135 0 7 38 5 R.IEGTK.G 6520 589.2065 588.1992 588.3595 -0.1603 0 9 20 1 K.TVTIR.A 6558 593.1535 592.1463 592.2639 -0.1176 0 5 17 4 R.EAAMR.A 6599 598.3397 597.3324 597.2983 0.0341 0 0 1.1e+002 7 K.QASHR.D 6729 617.2956 616.2883 616.3293 -0.0410 0 5 61 4 K.NVAGTR.S 6801 638.3493 637.3421 637.3547 -0.0127 1 1 94 5 K.YATRK.D 6826 648.3489 647.3416 647.3490 -0.0074 0 2 55 1 R.EGITTK.R 6891 672.3631 671.3559 671.3966 -0.0408 0 13 3.6 5 R.DGVLLR.D 7010 790.5622 789.5550 789.4232 0.1318 1 5 25 7 K.DVTAKEK.E 7011 7071 401.2404 800.4662 800.4756 -0.0094 1 21 0.59 8 K.KGDQILK.Q 7145 403.6964 805.3782 805.4446 -0.0664 0 2 41 7 K.TAFVNVR.V 7252 404.7310 807.4475 807.3334 0.1141 0 11 5.1 4 K.WSECAR.V 7255 7256 7257 7260 7262 404.7407 807.4668 807.4028 0.0640 1 2 38 9 K.WFKDGR.E 7285 405.2168 808.4190 808.4443 -0.0253 0 3 31 10 K.GTIYSLR.I 7360 406.2533 810.4920 810.5076 -0.0156 0 0 43 6 R.ILKPQGR.H 7364 406.7104 811.4062 811.4804 -0.0742 0 9 5.8 2 K.VTGTPPIK.I 7362 7363 7365 7366 7835 412.7559 823.4972 823.4552 0.0420 0 3 22 1 R.APTPSPVR.S 7792 7796 7846 413.2186 824.4227 824.5120 -0.0892 1 4 19 3 K.KPVPEKK.V 7876 413.7301 825.4456 825.4596 -0.0140 1 11 3.8 2 K.VPEEPKK.V 858 415.7268 829.4391 829.5385 -0.0994 1 5 23 8 K.IRISITK.R 8619 421.2659 840.5172 840.4817 0.0355 1 4 17 4 R.VNRDPIK.A 8511 8548 9585 422.7443 843.4740 843.4636 0.0104 0 11 6 6 K.IAGSLPMR.V 9681 424.7507 847.4868 847.5015 -0.0146 0 2 39 2 K.TVTSLSIK.E 9810 426.2424 850.4702 850.4661 0.0042 0 6 12 1 R.DQHVKPK.G 9843 426.7248 851.4351 851.4753 -0.0401 0 11 4.6 5 K.TTATFIAK.V 1528 9840 9841 9875 427.2487 852.4828 852.4817 0.0011 0 12 3.1 1 K.GRPAPEVK.W 9876 9932 428.2462 854.4778 854.4974 -0.0196 1 (4) 17 2 K.VPEVQKR.V 9903 9913 9937 10144 429.2748 856.5351 856.5746 -0.0395 1 4 25 6 K.VLVAVTKK.E 10170 429.7507 857.4869 857.4858 0.0011 0 11 6.2 8 K.EIIADGLK.Y 10186 430.2360 858.4575 858.4559 0.0016 0 5 23 1 K.QGIDLASR.A 1684 430.2476 858.4807 858.4963 -0.0156 0 10 21 4 R.NSILWVK.L 10199 430.6498 859.2850 859.4586 -0.1736 0 (5) 20 9 K.IAGSLPMR.V 10202 10321 433.2585 864.5024 864.5069 -0.0045 1 8 8.8 1 K.KVEPPAPK.V 10374 434.2381 866.4616 866.5225 -0.0609 1 4 22 3 K.VPAKVPEK.K 2470 436.1811 870.3476 870.5109 -0.1633 1 8 25 1 K.VPMKPKR.V 2482 11541 436.2395 870.4645 870.4923 -0.0278 1 3 33 9 K.VVPRSEGK.V 11654 437.2497 872.4848 872.5080 -0.0232 1 7 14 9 K.QIDKTLR.M 11715 437.7474 873.4802 873.4556 0.0246 0 8 11 8 K.AEGILTDR.A 11676 11682 11700 11733 11736 2634 438.2268 874.4391 874.4661 -0.0270 1 3 80 10 K.EGVRWTK.C 11901 440.7257 879.4369 879.4126 0.0243 0 10 5.4 8 K.AEAEWFK.E 11898 12011 442.7265 883.4384 883.4329 0.0055 1 8 7.5 3 R.TMMKVMK.L 12141 443.7579 885.5012 885.5647 -0.0636 1 13 3.3 1 K.VVISAAKAK.E 12130 2890 12143 12145 12151 12153 12156 12164 12170 444.2338 886.4531 886.5487 -0.0956 1 17 1.3 4 K.LEASKIVK.A 12480 448.7243 895.4341 895.4875 -0.0534 1 1 37 9 K.YTITSRR.G 12594 450.2573 898.5000 898.4218 0.0781 0 8 7.6 1 R.MFISETR.Q 12644 450.7219 899.4292 899.5301 -0.1008 1 2 31 9 R.LGRLGASAR.L 12657 450.7636 899.5126 899.5440 -0.0314 1 0 53 6 K.VVVAADKAK.E 12798 451.7546 901.4946 901.5233 -0.0287 0 1 54 7 R.VTLVDVTR.N

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13429 458.2352 914.4559 914.4974 -0.0415 0 13 3.4 5 R.QLPPSFAR.Q 13437 13440 13441 13540 459.2401 916.4656 916.4767 -0.0111 0 2 49 3 K.GVEFNVPR.L 13604 460.2186 918.4227 918.5386 -0.1159 1 9 8.1 2 R.TKEVITTK.Q 13638 3720 460.2261 918.4376 918.4811 -0.0435 0 2 1.9e+002 2 K.WSIVAESK.V 13775 462.7165 923.4185 923.4746 -0.0561 1 6 13 5 K.TVTTKCSK.T 13799 463.2501 924.4856 924.5029 -0.0172 1 2 29 7 K.ARVPEEPK.R 14065 466.7481 931.4816 931.4723 0.0093 1 12 4 7 R.TEEERLR.L 14140 467.7551 933.4956 933.5131 -0.0174 1 3 32 3 K.KSAATSLEK.S 14185 468.7330 935.4515 935.4560 -0.0045 0 2 32 4 K.TTDLTTER.L 14241 470.2609 938.5072 938.5185 -0.0113 1 1 34 1 K.DGQKLPPGK.D 14284 471.2181 940.4216 940.5705 -0.1489 1 1 42 6 K.LEPSRIVK.Q 14416 472.7673 943.5200 943.5199 0.0001 1 4 24 6 K.GESQLRVR.D 14426 473.2386 944.4626 944.4927 -0.0301 1 7 13 2 K.DGVEIEKR.M 14433 14493 474.2395 946.4644 946.5335 -0.0691 1 41 0.005 2 R.ISEEITKK.Q 14498 14545 474.7206 947.4266 947.5076 -0.0810 0 6 14 1 R.SVFPELTR.T 14542 14544 14561 474.7655 947.5164 947.5440 -0.0276 0 13 2.8 6 K.IIGYVVER.R 14556 14559 14560 14563 14565 474.7667 947.5189 947.4746 0.0443 0 8 9.7 5 R.VIAENMAGK.S 14547 14549 14552 14564 14598 475.7403 949.4661 949.4869 -0.0208 0 4 20 2 K.AAEPPSPPGK.V 14754 478.1936 954.3727 954.5498 -0.1771 1 0 41 2 K.EPAKIIER.A 14940 480.2689 958.5233 958.5083 0.0150 0 6 15 4 K.ANIAGATDVK.W 15027 482.2596 962.5047 962.4458 0.0590 0 3 32 7 K.TGTDEWVR.V 15079 483.7436 965.4726 965.5256 -0.0530 0 6 12 2 K.IMGYIIEK.I 4580 484.2699 966.5252 966.4692 0.0560 1 7 24 1 K.EMKDVTTK.L 15139 485.2642 968.5138 968.6131 -0.0993 1 11 4.4 4 R.LIGELRLR.V 15140 4607 485.3345 968.6544 968.5001 0.1543 0 0 87 1 K.AMTLGVSYK.V 15275 487.7532 973.4919 973.5193 -0.0273 1 6 17 7 K.DGKAITQGGK.Y 15436 490.2548 978.4950 978.5498 -0.0548 1 1 47 9 R.VTRFEISK.L 15471 491.2646 980.5147 980.5035 0.0112 0 6 14 2 K.LTVLNMMK.D 15480 491.7856 981.5567 981.4992 0.0576 1 2 31 4 K.EAVRADHGK.Y 15759 497.2258 992.4369 992.3506 0.0864 0 2 32 9 K.MPDDDGGDR.I 15793 497.7369 993.4592 993.4702 -0.0109 1 3 27 6 K.AGTERWMK.V 4973 498.2697 994.5249 994.4542 0.0707 0 2 76 5 R.WDTAMTVR.A 15840 498.2954 994.5763 994.5560 0.0203 1 6 13 8 R.HVQKQIDK.T 15838 4987 499.2683 996.5220 996.4950 0.0270 1 6 30 4 R.ISMDPKYK.D 16005 501.7844 1001.5542 1001.5393 0.0149 0 6 15 4 K.NPEVTTITK.D 16008 5072 16011 16122 503.7353 1005.4561 1005.4879 -0.0318 1 11 4.4 2 R.QSGDSAWKK.S 16126 16127 16128 503.7395 1005.4644 1005.4727 -0.0083 0 14 2.4 2 K.TSQASEEVR.T 16120 16121 16124 16125 16129 16131 16132 16134 16205 505.7370 1009.4595 1009.6172 -0.1577 0 4 20 10 R.VTGIPTPVVK.F 16281 507.7487 1013.4828 1013.5757 -0.0929 0 12 3.9 3 K.DLTIQPSLK.L 5233 16275 16277 16278 16279 16282 16482 510.7368 1019.4590 1019.5400 -0.0809 0 5 19 2 R.ITDQYRPK.W 16486 16484 510.7439 1019.4732 1019.5611 -0.0879 1 9 7.7 1 R.VSITTTKDR.T 16769 515.2890 1028.5634 1028.4961 0.0674 0 16 1.2 2 K.VLDSPGPCGK.L 5322 16770 5324 5326 16773 16775 16776 5328 53 16797 516.2659 1030.5172 1030.5407 -0.0235 0 8 8.9 4 K.VTNDNLLSR.K 17108 521.2776 1040.5406 1040.5978 -0.0572 1 8 7.9 10 K.LLTSSQKHK.F 17592 526.7638 1051.5130 1051.5186 -0.0056 0 6 12 2 K.LQDYTGVEK.D 17656 528.7626 1055.5106 1055.5764 -0.0657 0 8 9.2 4 K.GKPAPSVSWK.K 17648 17657 17688 529.2592 1056.5038 1056.4546 0.0492 1 2 32 8 K.YGEDSCKAK.L 17716 529.7447 1057.4749 1057.5655 -0.0906 0 5 22 2 K.APEIIDVSSK.A 17709 17710 17713 17852 531.2595 1060.5045 1060.5401 -0.0356 0 7 11 2 K.GVASAVVSDEK.Q 17873 531.2864 1060.5583 1060.5706 -0.0122 1 8 9.9 1 K.ADAPVKWFK.D 17976 532.7699 1063.5251 1063.5145 0.0106 0 3 26 3 K.AENSIGTASSK.T 17999 532.8255 1063.6363 1063.6026 0.0338 1 3 29 7 K.IVGYSIEKR.Q 17998 18230 536.7738 1071.5330 1071.6077 -0.0747 1 8 11 6 R.LIGTEKFHK.V 18426 538.7321 1075.4496 1075.5873 -0.1378 1 0 50 10 K.DGKLLTSSQK.H 18446 538.7936 1075.5726 1075.6614 -0.0888 1 16 1.4 2 R.ILKPQGRHK.T 18457 539.2149 1076.4153 1076.6077 -0.1925 1 5 17 9 K.KSTVTIVDSK.R 18465 18502 539.7557 1077.4968 1077.6182 -0.1214 1 5 17 7 K.LTGYIVEKR.D 5916 542.1884 1082.3623 1082.5543 -0.1919 0 1 49 2 K.CHVTGTAPIK.I 5921 542.2613 1082.5081 1082.5608 -0.0526 1 5 37 2 R.ADSSKFSLTK.A 18720 544.2861 1086.5575 1086.5193 0.0383 0 9 7.1 3 K.VPEESEELR.S 18704 18714 18723 18868 545.7242 1089.4339 1089.4938 -0.0599 1 6 16 6 K.EEGELDKDR.V 18870 545.7490 1089.4833 1089.5666 -0.0832 1 0 56 5 K.NGVEIKSTDK.C 19193 551.8100 1101.6055 1101.5488 0.0566 0 6 15 4 K.VLDTPAACQK.L 19190 19223 552.3155 1102.6163 1102.5117 0.1046 0 4 27 5 R.MPYDVPEPR.K 19253 553.2503 1104.4860 1104.5927 -0.1067 1 0 55 8 K.ERSSILWSK.A 19419 554.7272 1107.4398 1107.6288 -0.1890 1 5 15 1 K.ITSYIVEKR.D 19514 556.2792 1110.5439 1110.5709 -0.0271 1 0 42 7 K.LSWYKGTEK.L 19570 557.8387 1113.6629 1113.6659 -0.0029 1 2 32 4 K.LVIRTTHFK.V 6170 559.7782 1117.5419 1117.5251 0.0168 0 10 5.9 4 K.GDEEIIETGR.Y 19675 560.3306 1118.6466 1118.5325 0.1142 1 2 34 1 R.MSPARMSPAR.M 19723 561.2706 1120.5266 1120.6492 -0.1225 1 2 32 7 K.ITNYIIEKK.E 19937 563.2776 1124.5407 1124.5502 -0.0095 1 1 38 9 K.EVTWYKDGK.K 19955 563.7482 1125.4818 1125.5778 -0.0960 1 1 35 5 K.SNGKYTITSR.R 20439 572.7544 1143.4943 1143.5884 -0.0941 1 12 3.2 2 K.DGEPLKQTTR.V 20502 573.8107 1145.6068 1145.6656 -0.0588 1 28 0.085 3 K.KLSDISTVVGK.E 20538 575.2747 1148.5348 1148.5648 -0.0300 0 5 16 3 K.WVTCASAVQK.T 20617 576.2719 1150.5293 1150.6822 -0.1529 1 2 34 2 K.DGSIHRLIIK.D 20694 578.2711 1154.5276 1154.5819 -0.0543 0 5 13 8 K.STDFATSLSVK.D 20828 581.3022 1160.5899 1160.6223 -0.0324 1 11 4.3 3 K.IEGDLRAMLK.K 20826 20827 20829 20830 20831 20832 21018 585.2965 1168.5784 1168.6101 -0.0317 1 1 40 5 R.HAQAAYRQPK.Q 21089 589.2947 1176.5747 1176.6502 -0.0755 1 5 16 5 K.EIIADGLKYR.I 21088 21097 21219 590.7753 1179.5360 1179.6070 -0.0710 1 10 4.6 3 R.ATAVIKFCDR.S 21297 592.8034 1183.5922 1183.6210 -0.0288 0 2 33 6 K.GRPQATVNWR.K 21689 600.2552 1198.4958 1198.5843 -0.0885 1 8 7.9 2 R.RHDKPDFER.V 21733 601.3014 1200.5882 1200.5734 0.0148 0 9 7.2 2 R.AENAAGISEPSR.A 21730 21731 22184 608.7982 1215.5819 1215.6863 -0.1044 1 10 5.5 2 R.EQLKIDVPFK.G 22318 611.7982 1221.5818 1221.7081 -0.1263 1 1 41 8 R.VVAEEKVPVPR.K 22425 615.3068 1228.5991 1228.5935 0.0056 0 6 12 3 R.VEAEPAEVTER.Q 22436 615.7923 1229.5700 1229.7278 -0.1578 1 0 51 3 K.TLILRAGVTMR.L 22672 618.7761 1235.5376 1235.6299 -0.0923 0 5 16 2 K.LIPNGQYEFR.V 22673 22696 619.7995 1237.5845 1237.6819 -0.0974 0 2 31 9 K.ALDPLHPPGPPK.D

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22811 622.3202 1242.6258 1242.5881 0.0377 0 2 26 8 K.LTTGEEYQFR.I 22882 624.3284 1246.6422 1246.6227 0.0195 1 11 3.9 5 K.EMTPREEIVK.K 23190 631.8085 1261.6025 1261.6740 -0.0715 0 10 5.3 2 R.VLGYVVEMQPK.G 23163 23181 23183 23189 23191 23193 23488 425.9104 1274.7094 1274.6871 0.0223 1 4 18 5 K.TWSTVTPEVKK.T 23686 429.2270 1284.6591 1284.7653 -0.1061 1 4 16 3 K.TTPATLALEKIK.A 23826 646.7881 1291.5617 1291.7136 -0.1519 1 7 10 1 K.EAPPAKVPEVQK.R 1791 432.2380 1293.6921 1293.7366 -0.0445 1 3 1.8e+002 1 K.IMGYIIEKIAK.G 1780 23990 650.3041 1298.5937 1298.7194 -0.1257 1 4 19 8 R.TVLISSEGKTHK.L 24220 654.3192 1306.6237 1306.6227 0.0010 0 4 20 6 K.DVWMPVTSASAK.T 24221 24408 657.7949 1313.5753 1313.7456 -0.1703 1 7 9.4 2 K.VGLKGVEFNVPR.L 24428 658.3606 1314.7067 1314.7184 -0.0116 0 11 4 3 K.AGEDVQVLIPFK.G 24685 665.8410 1329.6674 1329.7293 -0.0619 0 11 3.7 4 R.EPVNPPGPPTVVK.V 25065 450.9036 1349.6891 1349.8183 -0.1293 1 5 15 7 R.LYVPVKGRPPPK.I 25157 452.2097 1353.6074 1353.7326 -0.1252 1 2 31 4 R.VMKSLSLQYSAK.D 6907 679.8946 1357.7747 1357.6071 0.1676 1 3 22 3 K.SELDFMSKEEK.S 25399 683.3547 1364.6949 1364.6493 0.0456 0 2 34 10 R.DVTAEDSASIMVK.A 25500 686.3441 1370.6735 1370.7518 -0.0782 1 7 9 6 K.VQEVQGRDLLSK.E 25499 3901 466.2744 1395.8013 1395.7973 0.0040 0 3 90 1 K.GLSDPVTIGPITVK.E 26017 472.6292 1414.8657 1414.8184 0.0473 1 2 19 1 K.EKPPPAKVPEVPK.K 26140 714.8216 1427.6287 1427.6537 -0.0250 1 3 23 5 R.KAGMNDAGLYTCK.V 26420 490.8994 1469.6763 1469.7991 -0.1227 1 0 42 3 R.KPVSEVGDGRWLK.C 5187 505.2805 1512.8198 1512.7970 0.0228 1 11 16 3 K.AAEVPAPIRDLSMK.D 26911 516.6042 1546.7909 1546.7627 0.0282 0 0 39 4 R.DVASAQWSPLSATSK.K 27405 559.2395 1674.6967 1674.7308 -0.0341 0 3 17 2 K.GDAGQYTCYASNIAGK.D 6306 569.2495 1704.7266 1704.8254 -0.0987 1 9 18 1 R.GEFGIVHRCVETSSK.K 27511 428.0135 1708.0249 1707.9155 0.1094 0 1 18 1 K.EPSPNLQLQIVQSQK.T 27835 619.9678 1856.8815 1857.0247 -0.1433 1 0 31 1 K.ALAEEGKITIPTFKPDK.I

254. Q13404|UB2V1_HUMAN Mass: 16598 Score: 54 Queries matched: 6 emPAI: 0.23 Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens GN=UBE2V1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10105 428.7648 855.5151 855.5178 -0.0027 0 1 45 8 K.VVLQELR.R 18399 538.2769 1074.5393 1074.5498 -0.0105 0 16 1.5 2 K.YPEAPPFVR.F 18400 21343 594.2997 1186.5848 1186.6081 -0.0233 0 54 0.00022 1 R.LLEELEEGQK.G 21345 27456 422.9680 1687.8430 1687.7948 0.0482 0 0 39 2 K.INMNGVNSSNGVVDPR.A

255. P01034|CYTC_HUMAN Mass: 16017 Score: 53 Queries matched: 3 emPAI: 0.24 Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 22393 613.7965 1225.5785 1225.5979 -0.0194 0 53 0.00027 1 R.ALDFAVGEYNK.A 22392 32661 503.0901 3012.4969 3012.3456 0.1513 1 2 12 1 K.AFCSFQIYAVPWQGTMTLSKSTCQDA.-

256. P14780|MMP9_HUMAN Mass: 79492 Score: 53 Queries matched: 11 emPAI: 0.10 Matrix metalloproteinase-9 OS=Homo sapiens GN=MMP9 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11648 437.2438 872.4730 872.4175 0.0555 0 11 5.9 1 R.CGVPDLGR.F 11630 14923 480.2104 958.4062 958.3967 0.0095 0 16 1.6 1 K.AYFCQDR.F 14921 15385 489.2530 976.4914 976.4978 -0.0064 0 49 0.00075 1 R.AVIDDAFAR.A 4785 15383 15386 15390 18645 542.7674 1083.5203 1083.5237 -0.0034 0 27 0.11 1 R.FQTFEGDLK.W 18642

257. P20700|LMNB1_HUMAN Mass: 66653 Score: 52 Queries matched: 13 emPAI: 0.18 Lamin-B1 OS=Homo sapiens GN=LMNB1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18 400.7446 799.4746 799.4803 -0.0058 0 30 0.063 1 K.LQIELGK.C 11666 437.7023 873.3901 873.4556 -0.0655 0 5 26 4 R.LVEVDSGR.Q 15167 486.7277 971.4408 971.4600 -0.0191 0 5 22 3 R.QIEYEYK.L 15268 487.7303 973.4461 973.4716 -0.0255 0 9 7.4 1 K.LLEGEEER.L 16935 517.2853 1032.5561 1032.5022 0.0540 1 1 46 9 K.EREMAEIR.D 19182 551.7651 1101.5157 1101.5666 -0.0508 1 6 13 5 R.KLLEGEEER.L 20688 577.8062 1153.5978 1153.6091 -0.0113 0 32 0.029 1 R.AGGPTTPLSPTR.L 21040 587.3126 1172.6106 1172.6401 -0.0295 1 35 0.016 1 K.DAALATALGDKK.S 21760 601.7875 1201.5605 1201.6302 -0.0697 1 6 15 3 K.KESDLNGAQIK.L 21761 22860 623.8150 1245.6154 1245.6452 -0.0298 1 2 32 10 K.KSLEGDLEDLK.D 25923 704.3538 1406.6930 1406.7153 -0.0224 1 4 16 9 K.ALYETELADARR.A 25921

258. P20674|COX5A_HUMAN Mass: 16923 Score: 52 Queries matched: 1 emPAI: 0.23 Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens GN=COX5A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16546 511.7628 1021.5111 1021.5193 -0.0081 0 52 0.00032 1 R.LNDFASTVR.I

259. P07476|INVO_HUMAN Mass: 68551 Score: 52 Queries matched: 6 emPAI: 0.17 Involucrin OS=Homo sapiens GN=IVL PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12879 452.2683 902.5221 902.4709 0.0512 1 1 47 9 K.QLEEEKK.L 21397 597.2759 1192.5372 1192.5836 -0.0464 0 10 4.4 1 K.HLEQQEGQPK.H 21943 605.3010 1208.5875 1208.6149 -0.0275 0 22 0.29 1 K.HLEQQEGQLK.H 21951 605.7953 1209.5760 1209.5989 -0.0230 0 32 0.03 1 K.HLEEQEGQLK.H 22648 618.3050 1234.5954 1234.6193 -0.0239 0 39 0.0062 1 K.YLEQQEGQLK.H 26949 520.2544 1557.7415 1557.7536 -0.0121 0 19 0.57 1 K.HLEHPEQQDGQLK.H

260. Q15819|UB2V2_HUMAN Mass: 16409 Score: 52 Queries matched: 6 emPAI: 0.53 Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens GN=UBE2V2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10105 428.7648 855.5151 855.5178 -0.0027 0 1 45 8 K.VVLQELR.R 16249 507.2317 1012.4487 1012.6029 -0.1542 1 3 23 4 M.AVSTGVKVPR.N

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16306 508.2625 1014.5103 1014.5134 -0.0031 0 23 0.28 1 K.YPEAPPSVR.F 16303 21343 594.2997 1186.5848 1186.6081 -0.0233 0 54 0.00022 1 R.LLEELEEGQK.G 21345

261. P16070|CD44_HUMAN Mass: 82017 Score: 52 Queries matched: 5 emPAI: 0.09 CD44 antigen OS=Homo sapiens GN=CD44 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13180 454.2154 906.4162 906.4117 0.0045 0 30 0.06 1 R.TEAADLCK.A 16920 517.2659 1032.5172 1032.5393 -0.0221 0 46 0.0014 1 R.FAGVFHVEK.N 17134 521.7736 1041.5327 1041.5243 0.0084 1 12 3.6 1 R.YVQKGEYR.T 20663 577.2987 1152.5828 1152.5597 0.0231 0 8 8.8 1 K.ALSIGFETCR.Y 20657

262. P15880|RS2_HUMAN Mass: 31590 Score: 50 Queries matched: 7 emPAI: 0.12 40S ribosomal protein S2 OS=Homo sapiens GN=RPS2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5353 516.2896 515.2823 515.2928 -0.0105 1 2 65 10 R.GRGAR.G 9846 426.7290 851.4434 851.4389 0.0045 0 24 0.23 1 K.ATFDAISK.T 9844 16656 513.3014 1024.5883 1024.5917 -0.0034 0 39 0.0064 1 R.GTGIVSAPVPK.K 16653 16662 6329 570.2649 1138.5152 1138.5441 -0.0289 0 2 70 8 R.GCTATLGNFAK.A

263. P46926|GNPI1_HUMAN Mass: 32819 Score: 50 Queries matched: 9 emPAI: 0.11 Glucosamine-6-phosphate isomerase 1 OS=Homo sapiens GN=GNPDA1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13265 456.2303 910.4461 910.5058 -0.0597 0 (0) 43 9 K.GLMLVHNK.L 13825 464.2150 926.4155 926.5008 -0.0853 0 4 19 7 K.GLM LVHNK.L 17502 524.3062 1046.5977 1046.6012 -0.0034 0 3 28 1 K.LVDPLYSIK.E 17501 20397 571.8095 1141.6045 1141.6131 -0.0087 0 43 0.0028 1 R.IIQFNPGPEK.Y 20395 20396 20398 23756 430.5397 1288.5972 1288.6809 -0.0837 0 1 42 1 K.TLAMDTILANAR.F

264. P49327|FAS_HUMAN Mass: 275877 Score: 50 Queries matched: 19 emPAI: 0.03 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1427 423.7539 845.4933 845.4759 0.0174 0 24 0.29 1 K.AGLYGLPR.R 11994 442.2513 882.4879 882.5287 -0.0408 0 0 42 6 R.DGVVRPLK.C 12517 449.2510 896.4874 896.4967 -0.0093 0 18 0.68 1 K.LSPDAIPGK.W 3159 13133 453.7465 905.4784 905.5083 -0.0299 1 2 41 7 R.FRDSILR.S 16235 506.7479 1011.4812 1011.6328 -0.1516 0 4 19 10 R.VAAAVDLIIK.S 17044 519.7699 1037.5252 1037.5393 -0.0141 0 1 45 10 R.VFTTVGSAEK.R 17187 522.2929 1042.5712 1042.5771 -0.0059 0 34 0.024 1 K.AQVADVVVSR.W 18151 535.2661 1068.5177 1068.5200 -0.0023 0 41 0.0036 1 R.DPSQQELPR.L 18334 537.3088 1072.6030 1072.5302 0.0729 0 8 11 8 R.QVQPEGPYR.V 19160 550.8180 1099.6214 1099.6713 -0.0500 1 3 32 4 R.GVQKLVLTSR.S 19161 19162 20427 572.3037 1142.5929 1142.6044 -0.0115 1 0 54 7 R.ASGRTPEAVQK.L 22883 416.5592 1246.6559 1246.6418 0.0140 0 4 19 2 K.VSVHVIEGDHR.T 24462 439.8613 1316.5620 1316.7023 -0.1403 1 1 35 3 K.AKYHGNVM LLR.A 24463 659.2890 1316.5634 1316.7023 -0.1389 1 0 45 9 K.YHGNVMLLRAK.T 24818 670.3164 1338.6182 1338.7143 -0.0961 0 1 33 9 R.QQEQQVPILEK.F 25909 703.8287 1405.6427 1405.7388 -0.0960 0 1 34 8 K.VLQGDLVMNVYR.D

265. Q14315|FLNC_HUMAN Mass: 293407 Score: 50 Queries matched: 30 emPAI: 0.03 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8009 415.2386 828.4627 828.4705 -0.0078 0 17 1.4 1 K.AIVDGNLK.L 841 12386 447.7400 893.4655 893.5083 -0.0428 1 6 14 4 R.LTRTFTR.S 12384 13389 457.2928 912.5710 912.5141 0.0569 1 6 14 10 R.ASGRGLQPK.G 14200 469.2391 936.4636 936.5029 -0.0393 0 1 45 7 R.LGSFGSITR.Q 14600 475.7431 949.4716 949.4505 0.0211 0 3 27 7 K.AEIAFEDR.K 15164 486.2947 970.5749 970.5196 0.0554 1 8 7.7 3 R.ASGPGLERGK.V 15165 16160 504.2651 1006.5156 1006.5196 -0.0039 0 40 0.0062 1 K.IQQNTFTR.W 16150 16156 16161 17105 521.2754 1040.5363 1040.5502 -0.0139 1 17 1 1 K.GPKGTEEPVK.V 17102 17120 521.2869 1040.5592 1040.5727 -0.0135 1 10 5.3 1 K.VRASGPGLER.G 17592 526.7638 1051.5130 1051.6502 -0.1372 1 1 38 3 K.LKPGAPVRSK.Q 17597 527.2488 1052.4831 1052.4775 0.0057 0 36 0.013 1 K.NDNDTFTVK.Y 18395 538.2699 1074.5251 1074.6073 -0.0822 1 11 5.2 1 R.VKVYGPGVEK.T 18369 18374 18383 18387 18389 18393 18512 539.8201 1077.6255 1077.5124 0.1131 1 5 18 3 K.AEITCKDNK.D 20480 573.2790 1144.5434 1144.6452 -0.1018 1 2 38 2 K.GAGSGELKVTVK.G 22318 611.7982 1221.5818 1221.6466 -0.0647 1 2 30 6 R.ERLGSFGSITR.Q 25923 704.3538 1406.6930 1406.7266 -0.0337 1 8 6.4 3 R.VNVGEGSHPERVK.V 26929 775.3205 1548.6264 1548.7995 -0.1731 0 4 13 3 R.TSQLNVGTSTDVSLK.I

266. O43933|PEX1_HUMAN Mass: 143804 Score: 50 Queries matched: 17 emPAI: 0.05 Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6630 600.3517 599.3445 599.3279 0.0166 0 7 11 1 R.ENLPK.D 13392 457.2960 912.5774 912.5756 0.0018 0 8 8.2 5 K.TLLAGVIAR.E 18001 533.2387 1064.4629 1064.5358 -0.0729 1 34 0.021 2 K.GMMKELQTK.Q 18007 18008 18019 18023 18038 18592 541.2465 1080.4785 1080.5307 -0.0522 1 (32) 0.031 2 K.GMMKELQTK.Q 18590 18594 18981 547.2620 1092.5095 1092.5564 -0.0469 0 3 28 8 K.YIGASEQAVR.D 19207 552.2708 1102.5271 1102.6169 -0.0897 0 5 18 1 R.QLMSLVAGLR.N 19204 19949 563.3188 1124.6230 1124.6012 0.0219 0 1 38 8 R.LAHALNDMIK.E 6483 586.3518 1170.6890 1170.6244 0.0646 1 2 86 4 K.QNVLSPEKEK.Q 21616 599.3149 1196.6153 1196.6336 -0.0182 0 5 15 3 R.LNIEMHAVVR.I

267. P61916|NPC2_HUMAN Mass: 16902 Score: 49 Queries matched: 8 emPAI: 0.23 Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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7603 412.2068 822.3990 822.4123 -0.0133 0 7 9.8 1 K.SEYPSIK.L 7606 7617 16327 508.7549 1015.4953 1015.5121 -0.0168 0 40 0.0067 1 K.SGINCPIQK.D 16328 16330 16336 24576 442.5530 1324.6370 1324.7391 -0.1020 1 2 29 9 K.TYSYLNKLPVK.S

268. Q9UBG3|CRNN_HUMAN Mass: 53730 Score: 49 Queries matched: 6 emPAI: 0.14 Cornulin OS=Homo sapiens GN=CRNN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4108 472.2461 942.4777 942.4810 -0.0034 0 30 0.16 1 R.ELYSYLR.S 19793 561.7546 1121.4946 1121.5135 -0.0190 0 44 0.0023 1 R.TEGNCTALTR.G 19976 564.2694 1126.5242 1126.5156 0.0086 0 5 14 7 R.QEWSSTHPR.R 19975 20738 579.2905 1156.5665 1156.5010 0.0655 0 2 31 10 K.GQHYEGSSHR.Q 20732

269. P06702|S10A9_HUMAN Mass: 13291 Score: 49 Queries matched: 16 emPAI: 1.17 Protein S100-A9 OS=Homo sapiens GN=S100A9 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11819 439.2309 876.4472 876.4705 -0.0233 0 14 2.7 2 K.DLQNFLK.K 15160 486.2453 970.4760 970.4872 -0.0112 0 36 0.014 1 R.LTWASHEK.M 15158 15159 16117 503.2861 1004.5576 1004.5655 -0.0079 1 31 0.047 1 K.DLQNFLKK.E 16116 26343 485.9073 1454.7001 1454.7154 -0.0153 0 30 0.042 1 K.LGHPDTLNQGEFK.E 26339 26340 26341 26342 27309 549.6057 1645.7954 1645.7844 0.0110 0 7 7.9 3 K.QLSFEEFIMLMAR.L 27302 27308 27310 27311

270. P41250|SYG_HUMAN Mass: 83828 Score: 49 Queries matched: 9 emPAI: 0.09 Glycyl-tRNA synthetase OS=Homo sapiens GN=GARS PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10139 429.2307 856.4468 856.5130 -0.0662 1 9 8.5 1 K.AVAELKAR.K 13573 459.7442 917.4738 917.4818 -0.0080 0 35 0.018 1 K.ELSEALTR.H 13566 13568 14554 474.7565 947.4984 947.5076 -0.0092 0 11 4.8 1 R.LLEFNQGK.L 14681 476.2933 950.5721 950.4743 0.0979 1 2 34 9 R.AKMEDTLK.R 15519 492.7942 983.5738 983.5764 -0.0025 1 2 32 5 K.VGISPDKLR.F 15515 22879 624.3212 1246.6279 1246.6558 -0.0278 0 44 0.0022 1 K.TVNVVQFEPSK.G

271. Q96C23|GALM_HUMAN Mass: 37970 Score: 49 Queries matched: 2 emPAI: 0.10 Aldose 1-epimerase OS=Homo sapiens GN=GALM PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19265 553.7496 1105.4847 1105.5880 -0.1033 0 6 15 10 R.VLSNGVQFSR.I 26292 724.3676 1446.7206 1446.7355 -0.0148 0 49 0.00064 1 R.AVFGELPSGGGTVEK.F

272. P09496|CLCA_HUMAN Mass: 27174 Score: 48 Queries matched: 7 emPAI: 0.14 Clathrin light chain A OS=Homo sapiens GN=CLTA PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12368 447.2160 892.4175 892.4113 0.0062 0 11 4.3 2 R.LCDFNPK.S 15629 494.7494 987.4842 987.4985 -0.0143 0 41 0.0054 1 R.LEALDANSR.K 15631 15632 17492 524.2492 1046.4838 1046.5032 -0.0194 1 6 13 6 K.QEAEWKEK.A 17725 529.7699 1057.5253 1057.5404 -0.0151 0 10 6.7 3 R.LQSEPESIR.K 19612 558.7850 1115.5554 1115.5934 -0.0380 1 14 2 2 R.LEALDANSRK.Q

273. Q53RD9|FBLN7_HUMAN Mass: 49055 Score: 48 Queries matched: 5 emPAI: 0.08 Fibulin-7 OS=Homo sapiens GN=FBLN7 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10218 431.1550 860.2955 860.4174 -0.1220 0 3 32 2 R.MATASAPGR.A 11172 435.7647 869.5148 869.5334 -0.0186 0 40 0.0044 3 R.QLQQLLK.G 11113 2361 6318 569.3507 1705.0302 1704.8981 0.1320 1 4 50 1 K.TPITLFRMATASAPGR.A

274. P22061|PIMT_HUMAN Mass: 24806 Score: 48 Queries matched: 4 emPAI: 0.15 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens GN=PCMT1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4095 471.7561 941.4977 941.5294 -0.0317 0 41 0.004 1 R.VQLVVGDGR.M 14329 17790 530.7709 1059.5273 1059.5197 0.0077 0 2 41 9 K.DDPTLLSSGR.V 17822

275. Q96KP4|CNDP2_HUMAN Mass: 53187 Score: 48 Queries matched: 9 emPAI: 0.15 Cytosolic non-specific dipeptidase OS=Homo sapiens GN=CNDP2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6471 585.3594 584.3521 584.3646 -0.0125 0 5 13 1 K.TVIPR.K 15604 494.2934 986.5723 986.4709 0.1014 0 1 47 2 R.YNYIEGTK.M 5202 506.2350 1010.4555 1010.5470 -0.0915 0 11 13 1 -.MAALTTLFK.Y 5210 5900 540.7515 1079.4885 1079.4991 -0.0106 0 2 30 9 R.MM EVAAADVK.Q 19060 548.7003 1095.3860 1095.4940 -0.1080 0 (0) 33 4 R.MMEVAAADVK.Q 19537 556.8038 1111.5931 1111.5986 -0.0055 0 36 0.013 1 K.TGQEIPVNVR.F 22546 617.3241 1232.6336 1232.6401 -0.0065 0 38 0.0085 1 K.TVFGVEPDLTR.E 30407 433.8807 2597.2404 2597.2386 0.0018 0 1 18 2 K.VYMGHGGKPWVSDFSHPHYLAGR.R

276. P25789|PSA4_HUMAN Mass: 29750 Score: 48 Queries matched: 9 emPAI: 0.13 Proteasome subunit alpha type-4 OS=Homo sapiens GN=PSMA4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10170 429.7507 857.4869 857.4858 0.0011 0 30 0.074 1 K.EVEQLIK.K 10156 10172 12797 451.7543 901.4940 901.5233 -0.0292 0 1 60 8 K.VEIATLTR.E 16159 504.2622 1006.5098 1006.5084 0.0014 0 45 0.0017 1 R.TTIFSPEGR.L 16149 5150 16158 20587 575.8346 1149.6546 1149.6064 0.0483 1 5 17 5 K.VLNKTMDVSK.L

277. O15078|CE290_HUMAN Mass: 290892 Score: 48 Queries matched: 67 emPAI: 0.01 Centrosomal protein of 290 kDa OS=Homo sapiens GN=CEP290 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 52 402.2135 802.4124 802.4072 0.0052 0 7 58 6 K.AEVEDLK.Y

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7116 402.2162 802.4177 802.4185 -0.0007 0 48 0.0013 1 R.EISDIAR.R 7149 403.7038 805.3931 805.4731 -0.0801 1 2 39 5 K.TIGLM KK.V 8043 415.7397 829.4649 829.4909 -0.0260 1 14 2.9 5 K.LKAELEK.L 8178 418.7349 835.4552 835.4473 0.0078 0 10 6.6 1 R.ITQSLMK.M 8177 9758 425.7388 849.4630 849.3902 0.0728 0 18 1.1 5 K.QLEEGMK.E 9749 9763 9764 9769 425.7547 849.4948 849.4344 0.0604 0 3 33 1 R.LQFAESR.G 12695 451.2388 900.4630 900.4777 -0.0147 1 0 63 6 K.NELQRNK.G 12936 453.2243 904.4340 904.4865 -0.0525 0 10 6.9 5 K.ASGILTSEK.M 13499 458.7552 915.4959 915.4774 0.0186 1 6 15 7 K.QLEQKDR.E 13503 13879 464.7185 927.4224 927.5389 -0.1165 0 10 5.9 5 R.AENQILLK.E 13960 465.7607 929.5069 929.5294 -0.0224 1 14 2.3 2 K.ILAENSRK.I 14228 469.7484 937.4823 937.5206 -0.0383 1 1 38 3 K.LGHVRGSGR.S 14232 469.7574 937.5002 937.4981 0.0021 0 5 16 1 R.LANHQLDK.E 14233 14325 471.7398 941.4651 941.5294 -0.0643 0 14 2.3 1 K.VNEQLALR.N 14324 14326 14327 14483 473.7541 945.4936 945.4767 0.0169 0 16 1.5 1 K.EQVESINK.E 14507 474.2529 946.4913 946.4654 0.0259 1 3 27 1 R.QMAQERGK.R 14589 475.2689 948.5232 948.5392 -0.0160 1 7 12 7 K.YQRLLEK.A 14940 480.2689 958.5233 958.5699 -0.0466 1 7 12 2 R.EITELKVK.E 15270 487.7335 973.4524 973.5192 -0.0669 1 4 25 8 K.KVSQDLER.Q 15272 15458 490.7683 979.5221 979.4280 0.0940 0 6 12 7 K.LGNESSMDK.A 15457 15460 16178 504.7553 1007.4960 1007.4746 0.0214 0 1 48 6 K.QTAWDLM K.Q 16345 509.2562 1016.4979 1016.4999 -0.0020 1 9 8 5 K.AVSDADRQR.I 16552 512.2476 1022.4805 1022.5284 -0.0479 0 6 12 2 K.EGEVFTLTK.Q 5332 515.7448 1029.4750 1029.6070 -0.1320 0 13 3.2 8 K.IQSTLDILK.E 17006 518.8287 1035.6428 1035.5456 0.0972 1 15 1.6 2 K.LKIMQEMK.N 17164 522.2673 1042.5200 1042.5771 -0.0570 0 12 3.7 2 R.LAEQNILSR.D 17159 17165 17167 17175 17179 17180 17174 522.2744 1042.5342 1042.6022 -0.0680 0 19 0.67 1 K.ITVLQVNEK.S 17161 17162 17168 17169 5511 5512 17474 523.7911 1045.5676 1045.5655 0.0021 1 5 21 7 K.ELETDIAKK.N 18172 535.7534 1069.4922 1069.6244 -0.1322 1 3 29 8 K.KVNEQLALR.N 19040 547.7796 1093.5447 1093.4709 0.0737 0 7 9 2 R.AEMTAAAEER.I 19041 19042 19043 19045 19157 550.7541 1099.4937 1099.6138 -0.1201 1 4 22 1 K.WQAKIEGIR.N 20619 576.2747 1150.5348 1150.5540 -0.0192 0 5 17 6 K.MTVQLEETGK.R 20616 20622 20785 580.2835 1158.5525 1158.6496 -0.0970 1 0 54 6 K.LKELETDIAK.K 22817 622.3262 1242.6378 1242.6932 -0.0554 1 14 1.7 2 K.QSLIEELQRK.V 22954 626.2806 1250.5466 1250.7207 -0.1741 1 2 31 3 K.HLRQTIQSLR.R 29894 428.8861 2567.2726 2567.3918 -0.1192 1 3 11 1 R.LTSGLQGKPLTDNKQSLIEELQR.K

278. P49773|HINT1_HUMAN Mass: 13907 Score: 47 Queries matched: 2 emPAI: 0.28 Histidine triad nucleotide-binding protein 1 OS=Homo sapiens GN=HINT1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13183 454.2233 906.4321 906.4447 -0.0126 0 24 0.25 1 K.IIFEDDR.C 26023 708.8759 1415.7373 1415.7521 -0.0149 0 47 0.0008 1 K.AQVARPGGDTIFGK.I

279. P21926|CD9_HUMAN Mass: 25969 Score: 47 Queries matched: 3 emPAI: 0.51 CD9 antigen OS=Homo sapiens GN=CD9 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14321 471.7239 941.4333 941.4494 -0.0161 0 33 0.024 1 K.EVQEFYK.D 17584 526.2789 1050.5432 1050.5597 -0.0165 0 21 0.37 1 K.DVLETFTVK.S 21214 590.3250 1178.6355 1178.6547 -0.0192 1 45 0.0018 1 K.KDVLETFTVK.S

280. P07339|CATD_HUMAN Mass: 45037 Score: 47 Queries matched: 12 emPAI: 0.08 Cathepsin D OS=Homo sapiens GN=CTSD PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7532 410.7235 819.4324 819.4239 0.0085 0 48 0.001 1 R.VGFAEAAR.L 7530 5779 533.2767 1064.5389 1064.5390 -0.0001 0 28 0.31 1 K.LSPEDYTLK.V 18053 18068 18072 5783 22008 606.3640 1210.7135 1210.7186 -0.0051 1 11 3.3 2 R.IPLHKFTSIR.R 21989 21990 21998 22015

281. P61077|UB2D3_HUMAN Mass: 16904 Score: 47 Queries matched: 2 emPAI: 0.51 Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens GN=UBE2D3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7116 402.2162 802.4177 802.4185 -0.0007 0 48 0.0013 1 K.ELSDLAR.D 22201 609.3251 1216.6357 1216.6452 -0.0095 0 25 0.18 1 R.SQWSPALTISK.V

282. P06454|PTMA_HUMAN Mass: 12196 Score: 47 Queries matched: 3 emPAI: 0.75 Prothymosin alpha OS=Homo sapiens GN=PTMA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 20054 566.2587 1130.5028 1130.5204 -0.0175 0 32 0.034 1 K.EVVEEAENGR.D 20052 26977 522.5490 1564.6251 1564.6376 -0.0126 1 25 0.1 1 R.AAEDDEDDDVDTKK.Q

283. O95372|LYPA2_HUMAN Mass: 25063 Score: 47 Queries matched: 2 emPAI: 0.15 Acyl-protein thioesterase 2 OS=Homo sapiens GN=LYPLA2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8175 418.7236 835.4327 835.4440 -0.0113 0 47 0.0014 1 R.FGALTAEK.L 22455 616.2754 1230.5362 1230.7085 -0.1723 1 0 50 5 R.SVVTPARVQFK.T

284. P30740|ILEU_HUMAN Mass: 42829 Score: 46 Queries matched: 6 emPAI: 0.18 Leukocyte elastase inhibitor OS=Homo sapiens GN=SERPINB1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21883 604.3102 1206.6058 1206.6245 -0.0186 0 37 0.0098 1 R.LGVQDLFNSSK.A 6650 24203 435.8970 1304.6693 1304.6837 -0.0144 1 28 0.071 1 R.FQSLNADINKR.G 24201 24202 2463

285. Q96QK1|VPS35_HUMAN Mass: 92447 Score: 46 Queries matched: 6 emPAI: 0.04 Vacuolar protein sorting-associated protein 35 OS=Homo sapiens GN=VPS35 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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7174 403.7354 805.4563 805.4559 0.0004 0 25 0.19 1 R.GVQHPLR.G 8039 415.7281 829.4416 829.4406 0.0010 1 5 22 6 R.ERQELR.I 4130 472.2749 942.5352 942.4420 0.0932 0 4 67 3 K.HFGAGGNQR.I 14369 17067 520.3151 1038.6156 1038.5280 0.0876 1 3 25 8 K.VQSFQMKR.C 22817 622.3262 1242.6378 1242.6568 -0.0190 0 46 0.0011 1 R.LSQLEGVNVER.Y

286. P61313|RL15_HUMAN Mass: 24245 Score: 46 Queries matched: 3 emPAI: 0.16 60S ribosomal protein L15 OS=Homo sapiens GN=RPL15 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12549 449.7644 897.5142 897.4708 0.0433 0 1 41 5 K.QGYVIYR.I 15852 499.2545 996.4945 996.5036 -0.0090 1 4 19 10 R.AGRHCGALR.V 16388 509.7538 1017.4931 1017.5091 -0.0160 0 46 0.0015 1 R.SLQSVAEER.A

287. P14923|PLAK_HUMAN Mass: 82434 Score: 46 Queries matched: 6 emPAI: 0.09 Junction plakoglobin OS=Homo sapiens GN=JUP PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7375 406.7768 811.5390 811.5531 -0.0141 0 34 0.016 1 R.LVQLLVK.A 11801 438.7457 875.4768 875.4865 -0.0097 0 28 0.12 1 K.LLWTTSR.V 4996 499.7904 997.5663 997.5808 -0.0145 0 40 0.0055 1 R.LAEPSQLLK.S 18728 544.3053 1086.5960 1086.6437 -0.0477 0 13 2.9 1 R.LNYGIPAIVK.L 21741 601.3396 1200.6646 1200.6649 -0.0003 1 1 43 6 K.MAVRLADGLQK.M 22673 412.8615 1235.5628 1235.5782 -0.0154 1 2 30 1 R.ISEDKNPDYR.K

288. Q9HAB8|PPCS_HUMAN Mass: 33984 Score: 46 Queries matched: 4 emPAI: 0.23 Phosphopantothenate--cysteine ligase OS=Homo sapiens GN=PPCS PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2683 439.7154 877.4163 877.4116 0.0047 0 2 35 10 R.WAEVMAR.F 14401 472.7561 943.4976 943.5087 -0.0111 0 26 0.17 1 K.IVDNLQSR.H 17124 521.7538 1041.4931 1041.4880 0.0051 0 46 0.0013 1 R.FLDNFSSGR.R 19610 558.7790 1115.5435 1115.6663 -0.1228 1 6 13 3 R.RVVLVTSGGTK.V

289. P55884|EIF3B_HUMAN Mass: 92823 Score: 46 Queries matched: 3 emPAI: 0.04 Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens GN=EIF3B PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18293 537.2778 1072.5410 1072.4681 0.0729 1 3 31 6 R.TMM EDFRK.Y 21833 603.3533 1204.6920 1204.6604 0.0316 1 1 47 3 R.GIALWGGEKFK.Q 25309 680.7966 1359.5785 1359.6015 -0.0229 0 46 0.0012 1 R.AQAVSEDAGGNEGR.A

290. Q5T749|KPRP_HUMAN Mass: 67172 Score: 46 Queries matched: 6 emPAI: 0.18 Keratinocyte proline-rich protein OS=Homo sapiens GN=KPRP PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15045 483.2270 964.4395 964.4614 -0.0219 0 20 0.61 1 R.SEPIYNSR.C 15046 15048 19730 561.2788 1120.5431 1120.5625 -0.0194 1 20 0.61 1 R.RSEPIYNSR.C 6716 613.2970 1224.5795 1224.6146 -0.0351 0 42 0.0086 1 R.GRPAVCQPQGR.F 26662 500.2430 1497.7072 1497.7358 -0.0286 1 19 0.44 1 R.RLDQCPESPLQR.C

291. P07437|TBB5_HUMAN Mass: 50095 Score: 46 Queries matched: 10 emPAI: 0.15 Tubulin beta chain OS=Homo sapiens GN=TUBB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16729 514.7548 1027.4951 1027.5121 -0.0170 0 2 38 3 K.TAVCDIPPR.G 18074 533.2847 1064.5549 1064.4201 0.1348 0 3 28 2 K.NMMAACDPR.H 18465 539.2623 1076.5101 1076.5250 -0.0150 1 29 0.065 1 K.IREEYPDR.I 20433 572.3108 1142.6071 1142.6270 -0.0200 0 17 1.2 1 K.LAVNMVPFPR.L 1033 420.2142 1257.6206 1257.6830 -0.0623 1 1 1.4e+002 9 R.FPGQLNADLRK.L 24048 651.3142 1300.6139 1300.6299 -0.0160 0 37 0.0097 1 R.ISVYYNEATGGK.Y 24594 663.8402 1325.6658 1325.7126 -0.0468 1 10 5.1 2 K.TAVCDIPPRGLK.M 24593 26392 731.8587 1461.7027 1461.6769 0.0258 0 8 6.8 3 K.EVDEQMLNVQNK.N 26393

292. Q86YZ3|HORN_HUMAN Mass: 283140 Score: 45 Queries matched: 11 emPAI: 0.01 Hornerin OS=Homo sapiens GN=HRNR PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7990 414.7699 827.5253 827.4977 0.0276 1 5 19 7 K.LVQARNK.I 4519 482.2274 962.4402 962.4530 -0.0127 1 1 1.2e+002 6 R.SGQSSRGER.H 5622 524.2043 1046.3941 1046.4741 -0.0800 0 4 48 2 R.QGSGSGQSPSR.G 27046 528.8997 1583.6774 1583.7077 -0.0303 0 33 0.017 1 R.GPYESGSGHSSGLGHR.E 27044 27045 27047 27049 27050 27051 270

293. P30475|1B39_HUMAN Mass: 40645 Score: 45 Queries matched: 7 emPAI: 0.09 HLA class I histocompatibility antigen, B-39 alpha chain OS=Homo sapiens GN=HLA-B PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9707 425.2102 848.4058 848.4248 -0.0190 0 1 45 1 -.M LVMAPR.T 4535 483.2159 964.4172 964.4250 -0.0078 0 45 0.0033 1 R.FDSDAASPR.E 24515 660.8350 1319.6554 1319.6429 0.0124 1 13 2.5 3 K.TNTQTDRESLR.N 24512 24518 24519 24659 664.8249 1327.6353 1327.6996 -0.0643 1 2 30 9 K.WEAARVAEQLR.T

294. Q95604|1C17_HUMAN Mass: 41612 Score: 45 Queries matched: 2 emPAI: 0.09 HLA class I histocompatibility antigen, Cw-17 alpha chain OS=Homo sapiens GN=HLA-C PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 4535 483.2159 964.4172 964.4250 -0.0078 0 45 0.0033 1 R.FDSDAASPR.G 32955 521.1400 3120.7965 3120.6940 0.1026 1 2 3.1 1 M.RVM APQALLLLLSGALALIETWAGSHSMR.Y

295. P16152|CBR1_HUMAN Mass: 30641 Score: 44 Queries matched: 4 emPAI: 0.12 Carbonyl reductase [NADPH] 1 OS=Homo sapiens GN=CBR1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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8777 421.7499 841.4853 841.4083 0.0771 0 7 9.7 4 K.TNFFGTR.D 8680 9594 422.7643 843.5141 843.5178 -0.0037 0 43 0.0037 1 K.IGVTVLSR.I 9596

296. Q15907|RB11B_HUMAN Mass: 24588 Score: 44 Queries matched: 10 emPAI: 0.15 Ras-related protein Rab-11B OS=Homo sapiens GN=RAB11B PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12481 448.7371 895.4597 895.4988 -0.0391 1 1 38 5 K.SDLRHLR.A 14394 472.7356 943.4567 943.4763 -0.0196 0 26 0.17 2 R.AITSAYYR.G 14395 14396 15445 490.7269 979.4393 979.4610 -0.0218 0 23 0.28 1 R.NEFNLESK.S 17189 522.2996 1042.5847 1042.6023 -0.0176 0 37 0.011 1 K.VVLIGDSGVGK.S 17186 17188 26782 761.3481 1520.6817 1520.6783 0.0034 1 2 27 4 M.GTRDDEYDYLFK.V 26779

Proteins matching the same set of peptides: P62491|RB11A_HUMAN Mass: 24492 Score: 44 Queries matched: 10 Ras-related protein Rab-11A OS=Homo sapiens GN=RAB11A PE=1 SV=3

297. P02778|CXL10_HUMAN Mass: 11216 Score: 44 Queries matched: 2 emPAI: 0.84 C-X-C motif chemokine 10 OS=Homo sapiens GN=CXCL10 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13676 460.7466 919.4786 919.5048 -0.0262 0 37 0.013 1 R.VEIIATMK.K 26151 715.8541 1429.6935 1429.7388 -0.0452 0 37 0.0083 1 K.LEIIPASQFCPR.V

298. O75347|TBCA_HUMAN Mass: 12904 Score: 44 Queries matched: 5 emPAI: 0.31 Tubulin-specific chaperone A OS=Homo sapiens GN=TBCA PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6726 616.3453 615.3380 615.3955 -0.0575 1 12 14 1 R.LVKEK.V 18292 537.2766 1072.5387 1072.5513 -0.0125 0 44 0.0024 1 K.QAEILQESR.M 18701 543.8194 1085.6242 1085.6332 -0.0090 1 17 1 1 R.LVLDSVKLEA.- 20656 577.2656 1152.5166 1152.4935 0.0232 0 13 2.4 1 R.AEDGENYDIK.K 21375 596.3060 1190.5973 1190.6295 -0.0322 0 11 3.8 1 R.LEAAYLDLQR.I

299. Q9HC38|GLOD4_HUMAN Mass: 35170 Score: 44 Queries matched: 13 emPAI: 0.23 Glyoxalase domain-containing protein 4 OS=Homo sapiens GN=GLOD4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8233 420.7228 839.4310 839.4290 0.0021 0 7 10 2 K.FYLQNR.S 18335 537.3097 1072.6048 1072.6128 -0.0080 0 39 0.0078 1 K.VTLAVSDLQK.S 18257 18258 18259 18264 18276 18277 18278 18296 18631 542.3046 1082.5946 1082.5972 -0.0025 0 30 0.053 1 R.SLPQSDPVLK.V

300. P50552|VASP_HUMAN Mass: 39976 Score: 44 Queries matched: 6 emPAI: 0.09 Vasodilator-stimulated phosphoprotein OS=Homo sapiens GN=VASP PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6155 558.2998 557.2926 557.3649 -0.0724 1 1 1.3e+002 9 R.VVGRK.M 15175 486.7586 971.5027 971.5036 -0.0009 0 44 0.0028 1 R.VPAQSESVR.R 21029 586.3016 1170.5887 1170.5517 0.0371 0 1 39 9 K.QEEASGGPTAPK.A 22100 607.7947 1213.5748 1213.6918 -0.1170 1 19 0.59 2 R.VKQELLEEVK.K 22098 22101

301. P49207|RL34_HUMAN Mass: 13513 Score: 44 Queries matched: 4 emPAI: 0.29 60S ribosomal protein L34 OS=Homo sapiens GN=RPL34 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5970 544.3104 543.3031 543.2765 0.0266 0 7 17 5 R.TPGNR.I 15389 489.2614 976.5083 976.5229 -0.0146 0 44 0.0028 1 R.AFLIEEQK.I 15387 20127 567.2882 1132.5619 1132.6240 -0.0621 1 15 1.7 2 K.RAFLIEEQK.I

302. P22307|NLTP_HUMAN Mass: 59640 Score: 43 Queries matched: 7 emPAI: 0.06 Non-specific lipid-transfer protein OS=Homo sapiens GN=SCP2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9837 426.7151 851.4157 851.4905 -0.0748 0 4 23 2 K.IGGIFAFK.V 9836 14183 468.7313 935.4480 935.5110 -0.0630 1 6 13 3 K.M SKGSLGIK.F 23417 635.7708 1269.5271 1269.7081 -0.1810 0 1 31 6 K.WVINPSGGLISK.G 23419 23420 24563 662.3547 1322.6948 1322.7306 -0.0358 0 43 0.0022 1 K.LQNLQLQPGNAK.L

303. P80075|CCL8_HUMAN Mass: 11524 Score: 43 Queries matched: 1 emPAI: 0.34 C-C motif chemokine 8 OS=Homo sapiens GN=CCL8 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15199 487.2514 972.4882 972.5062 -0.0181 0 43 0.003 1 R.ITNIQCPK.E

304. Q8TF72|SHRM3_HUMAN Mass: 218125 Score: 43 Queries matched: 13 emPAI: 0.02 Protein Shroom3 OS=Homo sapiens GN=SHROOM3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7074 401.2410 800.4674 800.4392 0.0282 0 9 8.9 2 K.LGQEQVK.C 7114 402.2154 802.4163 802.4548 -0.0385 0 20 0.66 1 R.ISESVLR.D 7880 413.7665 825.5185 825.4344 0.0840 0 1 32 2 R.EPSLQPR.R 12171 444.2413 886.4680 886.5600 -0.0920 1 12 4.1 7 K.LSKVTIAR.E 13879 464.7185 927.4224 927.5753 -0.1528 1 10 5.9 5 K.AELLNKIK.E 14044 466.7348 931.4551 931.4723 -0.0171 1 40 0.0059 1 R.SSPATADKR.Q 14027 14065 16612 513.2387 1024.4629 1024.4244 0.0385 0 11 3.9 1 R.SGSMDNTSAR.G 16614 20470 573.2364 1144.4582 1144.5625 -0.1043 1 5 15 7 R.EPSSWGARAGK.S 20540 575.2855 1148.5565 1148.6302 -0.0737 0 4 19 5 R.SDVLAGPVHVR.S 22238 406.9062 1217.6968 1217.6802 0.0166 1 6 14 4 K.MKSTLLIEQR.K

305. P10109|ADX_HUMAN Mass: 19666 Score: 43 Queries matched: 6 emPAI: 0.20 Adrenodoxin, mitochondrial OS=Homo sapiens GN=FDX1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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14137 467.7541 933.4936 933.4767 0.0168 1 2 43 2 R.QSIDVGKTS.- 14481 473.7445 945.4745 945.5356 -0.0611 1 14 2.6 4 R.SLSVSARAR.S 14828 479.2462 956.4779 956.4927 -0.0148 0 43 0.003 1 R.VPETVADAR.Q 15021 482.2358 962.4570 962.4835 -0.0265 0 3 30 4 R.WLHHAGSR.A 15020 16669 513.7355 1025.4564 1025.5618 -0.1054 0 1 40 9 R.AASAVLGGPAGR.W

306. Q15643|TRIPB_HUMAN Mass: 228184 Score: 43 Queries matched: 44 emPAI: 0.02 Thyroid receptor-interacting protein 11 OS=Homo sapiens GN=TRIP11 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7461 408.7613 815.5081 815.4388 0.0693 0 4 27 8 R.LLEEANK.Y 8086 416.2439 830.4733 830.4498 0.0235 0 38 0.011 1 K.QIDQLSK.D 8097 11744 437.7669 873.5192 873.4192 0.1001 0 9 8.5 1 R.EALAAEDR.E 11742 11755 14465 473.2642 944.5139 944.5179 -0.0040 0 3 38 9 R.LTEQLDVK.E 14420 14889 479.3055 956.5965 956.5655 0.0310 0 15 1.8 2 K.QLTQLINK.K 15057 483.2452 964.4758 964.5342 -0.0584 1 8 9.8 4 K.IVETYRGK.E 15159 486.2406 970.4666 970.5811 -0.1145 0 1 42 10 K.LTQIIQQK.D 16012 501.8032 1001.5919 1001.5141 0.0777 1 10 7.1 3 K.KNAENLEGK.V 16458 510.2527 1018.4909 1018.6062 -0.1153 1 7 11 4 K.EIFIEKLK.E 16456 17671 529.2387 1056.4629 1056.5096 -0.0466 1 11 4.1 2 K.FSMMLREK.E 17677 17680 17699 529.3124 1056.6102 1056.4797 0.1305 0 1 41 5 K.AMYSAELEK.Q 19728 561.2770 1120.5394 1120.5070 0.0324 0 6 15 5 R.QEMLDDVQK.K 19711 19738 19743 20052 566.2580 1130.5015 1130.5819 -0.0804 0 9 6.9 2 K.DIEIDALSQK.C 22227 609.8184 1217.6223 1217.5888 0.0336 0 18 0.95 1 K.QQNEGDSIISK.L 22218 22220 22221 22222 22223 22224 22226 222 22906 625.3046 1248.5946 1248.6020 -0.0074 1 12 3.4 2 R.QEMLDDVQKK.L 23683 643.3082 1284.6019 1284.6939 -0.0920 1 2 32 3 R.RTDVNPFLAPR.S 6822 647.3162 1292.6179 1292.5740 0.0439 0 2 1.1e+002 4 R.QIMEECENLK.L 24724 445.9044 1334.6913 1334.6752 0.0162 1 1 41 8 K.MDITKELDVQK.E 3063 448.2251 1341.6536 1341.7728 -0.1192 1 3 93 1 R.ETIQNLSRIIR.E 32443 589.0923 2940.4253 2940.3170 0.1082 1 0 17 3 K.EMDEFRYQHEQMNATHTQLFLEK.D

307. P18510|IL1RA_HUMAN Mass: 20384 Score: 43 Queries matched: 12 emPAI: 0.19 Interleukin-1 receptor antagonist protein OS=Homo sapiens GN=IL1RN PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7290 405.2197 808.4248 808.4708 -0.0460 1 7 11 7 K.RFAFIR.S 7278 12755 451.7326 901.4506 901.4658 -0.0152 0 21 0.53 1 R.IWDVNQK.T 12756 12758 12759 12760 12761 14739 477.7099 953.4053 953.4753 -0.0699 1 4 17 3 K.SSKMQAFR.I 14743 14747 4784 489.1955 976.3764 976.3814 -0.0050 0 43 0.013 1 K.FYFQEDE.-

308. Q9H3K6|BOLA2_HUMAN Mass: 10281 Score: 42 Queries matched: 1 emPAI: 0.39 BolA-like protein 2 OS=Homo sapiens GN=BOLA2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18708 544.2693 1086.5240 1086.5458 -0.0218 0 42 0.0035 1 K.TLTPDQWAR.E

309. P04792|HSPB1_HUMAN Mass: 22826 Score: 42 Queries matched: 6 emPAI: 0.36 Heat shock protein beta-1 OS=Homo sapiens GN=HSPB1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3673 459.2416 916.4687 916.4866 -0.0179 0 1 2.1e+002 1 K.DGVVEITGK.H 14289 471.2472 940.4799 940.4978 -0.0178 0 33 0.026 1 R.AQLGGPEAAK.S 14284 14292 4889 494.2400 986.4655 986.6025 -0.1370 1 2 1e+002 2 R.RVPFSLLR.G 20867 582.2957 1162.5768 1162.6135 -0.0367 0 33 0.028 1 R.LFDQAFGLPR.L

310. Q14956|GPNMB_HUMAN Mass: 64623 Score: 42 Queries matched: 3 emPAI: 0.06 Transmembrane glycoprotein NMB OS=Homo sapiens GN=GPNMB PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15641 494.7866 987.5587 987.5753 -0.0166 0 30 0.066 1 R.AYVPIAQVK.D 15640 15645

311. P08648|ITA5_HUMAN Mass: 115605 Score: 42 Queries matched: 5 emPAI: 0.03 Integrin alpha-5 OS=Homo sapiens GN=ITGA5 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18346 537.7648 1073.5150 1073.5717 -0.0567 0 5 19 5 R.SSASSGPQILK.C 19114 549.7866 1097.5586 1097.5717 -0.0130 0 42 0.0032 1 K.AQLKPPATSDA.- 19113 21967 404.5410 1210.6011 1210.6055 -0.0043 0 7 8.9 1 R.TPDGRPQEVGR.V 21974

312. P13498|CY24A_HUMAN Mass: 21059 Score: 42 Queries matched: 2 emPAI: 0.18 Cytochrome b-245 light chain OS=Homo sapiens GN=CYBA PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 19117 549.8043 1097.5939 1097.6193 -0.0253 0 42 0.0032 1 R.ERPQIGGTIK.Q 19118

313. Q5JNZ5|RS26L_HUMAN Mass: 13336 Score: 42 Queries matched: 2 emPAI: 0.30 Putative 40S ribosomal protein S26-like 1 OS=Homo sapiens GN=RPS26P11 PE=5 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14330 471.7657 941.5169 941.5294 -0.0125 0 39 0.0061 1 R.NIVEAAAVR.D 14333

Proteins matching the same set of peptides: P62854|RS26_HUMAN Mass: 13292 Score: 42 Queries matched: 2 40S ribosomal protein S26 OS=Homo sapiens GN=RPS26 PE=1 SV=3

314. Q99575|POP1_HUMAN Mass: 116346 Score: 42 Queries matched: 18 emPAI: 0.03 Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens GN=POP1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3528 454.2523 906.4901 906.5174 -0.0274 1 42 0.0092 2 K.NLLEKYK.R 3518 13194 3524 3529 13198 13199 13200 13201 1320 14075 467.2225 932.4304 932.5001 -0.0697 0 (0) 57 2 R.AAEISAMLK.A 4213 475.2347 948.4549 948.4950 -0.0401 0 2 1.5e+002 3 R.AAEISAMLK.A

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22058 607.2828 1212.5511 1212.5986 -0.0475 0 3 22 2 K.AGPEGTSQEIPK.Y 22099 607.7938 1213.5730 1213.6302 -0.0573 1 6 14 2 R.KDDGENAKPIK.K

315. Q9NTJ3|SMC4_HUMAN Mass: 147775 Score: 42 Queries matched: 19 emPAI: 0.02 Structural maintenance of chromosomes protein 4 OS=Homo sapiens GN=SMC4 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7359 406.2496 810.4847 810.4752 0.0095 0 42 0.0033 1 K.ILGPFHK.R 7351 7356 265 7360 7548 411.1262 820.2379 820.4000 -0.1622 0 1 35 4 K.EVMDSLK.Q 3871 465.7383 929.4620 929.5182 -0.0561 1 9 7.9 1 K.AGKVEAEVK.R 15723 496.2826 990.5507 990.4804 0.0703 0 0 51 1 K.AM QIQEQK.V 17896 531.7587 1061.5028 1061.5791 -0.0763 1 2 39 4 K.LKEVMDSLK.Q 18914 546.7602 1091.5059 1091.5975 -0.0916 1 3 29 1 K.KIFNLSGGEK.T 19206 552.2708 1102.5269 1102.5804 -0.0535 1 5 18 5 K.KAMQIQEQK.V 19211 19770 561.3005 1120.5865 1120.6128 -0.0263 1 14 2.1 3 K.ITKFIEENK.E 19758 21526 598.3113 1194.6080 1194.5186 0.0893 0 5 13 3 K.M ESQLQNDSK.K 23447 636.3148 1270.6149 1270.6993 -0.0844 1 7 9.5 3 R.NLQKAQDSVLR.T 3976 469.2807 1404.8204 1404.7612 0.0591 1 1 1e+002 3 K.QKLLEENVSAFK.T 5316 515.2469 1542.7188 1542.7525 -0.0337 0 10 19 1 K.NTNAAEESLPEIQK.E 27349 550.2450 1647.7131 1647.8137 -0.1006 1 10 4.1 1 K.EINEKSNILSNEMK.A

316. P23526|SAHH_HUMAN Mass: 48255 Score: 42 Queries matched: 5 emPAI: 0.08 Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11825 439.2548 876.4949 876.4561 0.0388 0 4 27 2 K.MMANGILK.V 12054 442.7800 883.5455 883.5491 -0.0035 0 39 0.0063 1 R.IILLAEGR.L 12053 12933 453.2157 904.4168 904.4688 -0.0520 0 2 42 1 R.ATDVMIAGK.V 27495 853.8829 1705.7512 1705.9362 -0.1850 1 3 19 1 K.LDEAVAEAHLGKLNVK.L

317. P04440|DPB1_HUMAN Mass: 29426 Score: 42 Queries matched: 9 emPAI: 0.13 HLA class II histocompatibility antigen, DP beta 1 chain OS=Homo sapiens GN=HLA-DPB1 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3331 451.7385 901.4624 901.4869 -0.0244 1 3 35 9 K.DILEEKR.A 14590 475.2689 948.5232 948.4624 0.0608 1 7 11 5 K.AQSDSARSK.T 18189 536.2467 1070.4789 1070.4669 0.0120 0 33 0.025 1 R.FDSDVGEFR.A 5813 5814 18730 544.3424 1086.6703 1086.5856 0.0848 0 14 2.4 2 M.MVLQVSAAPR.T 21759 601.7852 1201.5558 1201.6311 -0.0753 0 (5) 19 2 -.MMVLQVSAAPR.T 532 412.2360 1233.6861 1233.6210 0.0652 0 5 46 1 -.MMVLQVSAAPR.T 548

318. P01918|HB21_HUMAN Mass: 29942 Score: 42 Queries matched: 6 emPAI: 0.13 HLA class II histocompatibility antigen, DQ(1) beta chain OS=Homo sapiens GN=HLA-DQB1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18189 536.2467 1070.4789 1070.4669 0.0120 0 33 0.025 1 R.FDSDVGEFR.A 5813 5814 19396 554.2861 1106.5577 1106.6196 -0.0619 1 10 6.2 2 R.LVSRSIYNR.E 6128 29319 425.7679 2548.5639 2548.4716 0.0923 0 2 1.8 1 K.M LSGIGGFVLGLIFLGLGLIIHHR.S

319. P42224|STAT1_HUMAN Mass: 87850 Score: 41 Queries matched: 9 emPAI: 0.04 Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens GN=STAT1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9559 422.2396 842.4647 842.4610 0.0037 0 7 14 2 K.ILENAQR.F 9556 15163 486.2741 970.5337 970.5559 -0.0222 1 41 0.0039 1 R.KILENAQR.F 16336 508.7702 1015.5258 1015.5549 -0.0291 1 11 5.1 10 K.KLEELEQK.Y 16337 17738 530.2647 1058.5149 1058.4776 0.0373 0 0 50 8 K.MYLMLDNK.R 6483 586.3518 1170.6890 1170.5777 0.1113 1 1 98 7 K.KMYLMLDNK.R 26104 713.3443 1424.6741 1424.7333 -0.0592 0 3 25 3 K.VMAAENIPENPLK.Y 26326 727.3383 1452.6620 1452.7572 -0.0953 0 2 25 8 K.TELISVSEVHPSR.L

320. P28482|MK01_HUMAN Mass: 41762 Score: 41 Queries matched: 3 emPAI: 0.09 Mitogen-activated protein kinase 1 OS=Homo sapiens GN=MAPK1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12339 446.2289 890.4433 890.4498 -0.0065 0 0 60 10 R.LFPNADSK.A 15274 487.7531 973.4917 973.4982 -0.0065 0 41 0.0056 1 R.GQVFDVGPR.Y 26719 754.3570 1506.6994 1506.7653 -0.0658 1 2 26 4 R.WYRAPEIMLNSK.G

321. P62701|RS4X_HUMAN Mass: 29807 Score: 41 Queries matched: 10 emPAI: 0.27 40S ribosomal protein S4, X isoform OS=Homo sapiens GN=RPS4X PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8059 416.2247 830.4348 830.4498 -0.0149 0 38 0.011 1 R.LTIAEER.D 882 8062 8070 915 4942 495.7886 989.5626 989.5910 -0.0284 0 22 0.37 1 R.LSNIFVIGK.G 15711 15838 498.2911 994.5677 994.4971 0.0706 0 3 26 5 K.YALTGDEVK.K 18358 537.7764 1073.5382 1073.5717 -0.0334 1 13 2.8 2 R.LTIAEERDK.R 20962 584.3416 1166.6687 1166.6560 0.0127 0 4 20 2 K.GNKPWISLPR.G

322. P01040|CYTA_HUMAN Mass: 11000 Score: 40 Queries matched: 5 emPAI: 0.36 Cystatin-A OS=Homo sapiens GN=CSTA PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9752 425.7332 849.4519 849.4596 -0.0077 0 30 0.059 1 K.LEAVQYK.T 9744 15152 485.7747 969.5348 969.5495 -0.0147 0 6 13 10 K.VKPQLEEK.T 17035 519.7271 1037.4397 1037.4666 -0.0268 1 40 0.0046 1 K.NKDDELTGF.- 17033

323. P28066|PSA5_HUMAN Mass: 26565 Score: 40 Queries matched: 3 emPAI: 0.14 Proteasome subunit alpha type-5 OS=Homo sapiens GN=PSMA5 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 17959 532.2603 1062.5060 1062.5094 -0.0034 0 40 0.0056 1 R.GVNTFSPEGR.L 17960 26298 483.2741 1446.8005 1446.7276 0.0730 0 8 7.8 1 R.ITSPLMEPSSIEK.I

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324. Q15369|ELOC_HUMAN Mass: 12636 Score: 40 Queries matched: 2 emPAI: 0.31 Transcription elongation factor B polypeptide 1 OS=Homo sapiens GN=TCEB1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16204 505.2755 1008.5365 1008.5604 -0.0239 0 19 0.63 1 R.EIPSHVLSK.V 17662 528.7771 1055.5396 1055.5611 -0.0215 0 40 0.006 1 R.EHALTSGTIK.A

325. A8K2U0|A2ML1_HUMAN Mass: 162427 Score: 40 Queries matched: 4 emPAI: 0.02 Alpha-2-macroglobulin-like protein 1 OS=Homo sapiens GN=A2ML1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5048 501.2742 1000.5339 1000.5553 -0.0214 0 40 0.023 1 K.AGLLTEEIR.S 18346 537.7648 1073.5150 1073.6121 -0.0971 1 7 13 3 K.FKVEVVEPK.E 22828 622.7914 1243.5683 1243.6884 -0.1201 1 7 11 7 K.AGLLTEEIRSR.A 30227 430.0800 2574.4364 2574.3549 0.0815 1 0 14 1 K.M LSGFSPMEGTNQLLLQQPLVKK.V

326. O15144|ARPC2_HUMAN Mass: 34426 Score: 40 Queries matched: 5 emPAI: 0.11 Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens GN=ARPC2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16777 515.3046 1028.5947 1028.6117 -0.0170 0 19 0.68 1 R.IIEETLALK.F 5331 19169 551.2573 1100.5000 1100.4961 0.0040 0 40 0.0059 1 R.NCFASVFEK.Y 19170 551.2619 1100.5092 1100.6012 -0.0919 0 8 8.8 1 -.MILLEVNNR.I 21647 599.7551 1197.4957 1197.6176 -0.1219 0 0 44 7 K.DSIVHQAGMLK.R

327. Q16543|CDC37_HUMAN Mass: 44953 Score: 40 Queries matched: 5 emPAI: 0.08 Hsp90 co-chaperone Cdc37 OS=Homo sapiens GN=CDC37 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14575 475.2364 948.4582 948.4400 0.0182 1 9 7.1 1 K.TGDEKDVSV.- 16481 510.7234 1019.4323 1019.4971 -0.0648 1 2 34 1 K.VDPRACFR.Q 16920 517.2659 1032.5172 1032.5274 -0.0102 0 7 11 7 K.SMVNTKPEK.T 17663 528.7907 1055.5668 1055.5723 -0.0055 0 40 0.0062 1 R.LQAEAQQLR.K 17664

328. O43150|ASAP2_HUMAN Mass: 112835 Score: 40 Queries matched: 29 emPAI: 0.03 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens GN=ASAP2 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12810 451.7570 901.4994 901.4869 0.0125 0 2 41 7 K.SALQVEQK.E 15089 484.2197 966.4248 966.5359 -0.1110 1 4 19 5 K.LQPSPNRR.E 15088 4576 15217 487.2601 972.5057 972.5240 -0.0183 0 38 0.011 2 K.EIISEVQR.M 15200 15205 15206 15208 15209 15212 15213 15215 15 15902 500.7873 999.5600 999.6077 -0.0476 1 1 49 1 K.SQATKLKPK.R 16819 516.2918 1030.5691 1030.4792 0.0899 1 8 10 4 K.QAQDEERR.Q 17662 528.7771 1055.5396 1055.5433 -0.0038 0 14 2.1 2 K.LHSLCEAVK.T

329. Q15648|MED1_HUMAN Mass: 169342 Score: 39 Queries matched: 64 emPAI: 0.02 Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens GN=MED1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12118 443.7129 885.4113 885.4556 -0.0443 0 3 30 5 K.ATNAGPLDK.I 13639 460.2459 918.4772 918.4155 0.0617 0 2 43 3 R.QNSSSGSPR.M 13633 16009 501.7888 1001.5631 1001.5692 -0.0061 1 8 10 4 K.LVRQVMEK.R 16005 16006 16010 5822 536.2887 1070.5629 1070.6335 -0.0707 0 1 1.3e+002 3 K.KPSLTAVIDK.L 18875 545.7687 1089.5228 1089.5488 -0.0261 0 (7) 13 3 K.VTSLPAMTDR.L 18871 18872 19304 553.7890 1105.5634 1105.5438 0.0196 0 16 1.4 4 K.VTSLPAMTDR.L 19265 19266 19267 19268 19270 19273 19274 1927 19391 554.2758 1106.5370 1106.4727 0.0643 0 34 0.021 3 K.AQGETEESEK.L 19361 19362 19363 19366 19367 19368 19369 1937 2766 440.8600 1319.5580 1319.6721 -0.1141 0 0 48 1 K.NYGSPLISGSTPK.H 5279 511.2608 1530.7605 1530.7638 -0.0033 0 1 1e+002 2 K.NSSQSGGKPGSSPITK.H 27021 526.2250 1575.6533 1575.8048 -0.1515 1 0 30 1 K.VVQRCMSIPVTMR.A

330. P46781|RS9_HUMAN Mass: 22635 Score: 39 Queries matched: 8 emPAI: 0.37 40S ribosomal protein S9 OS=Homo sapiens GN=RPS9 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5046 501.2716 500.2644 500.3322 -0.0679 0 4 75 9 K.LGLAK.S 5041 6536 590.2675 589.2602 589.3071 -0.0469 0 2 1.2e+002 1 R.LDSQK.H 858 415.7268 829.4391 829.4545 -0.0154 0 35 0.022 1 R.IGVLDEGK.M 13690 461.2331 920.4517 920.4603 -0.0086 0 28 0.1 1 K.IEDFLER.R 3738 14120 467.7438 933.4731 933.5535 -0.0804 0 6 15 4 K.LDYILGLK.I 16475 510.2994 1018.5843 1018.5924 -0.0080 1 6 14 5 R.RLQTQVFK.L

331. O14647|CHD2_HUMAN Score: 39 Queries matched: 16 Chromodomain-helicase-DNA-binding protein 2 OS=Homo sapiens GN=CHD2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 235 405.3250 808.6355 808.4668 0.1688 1 7 22 1 R.AHRIGQK.K 363 410.2267 818.4388 818.4134 0.0254 1 1 96 3 K.KDDVTGGK.K 7518 9537 422.1898 842.3649 842.4498 -0.0848 0 0 56 6 K.QLDKPDK.G 16022 502.2541 1002.4937 1002.5094 -0.0157 0 0 56 3 R.TILENNSGR.S 18309 537.2858 1072.5571 1072.6492 -0.0921 1 12 3.7 8 R.SSGKLILLDK.L 18319 21621 599.3448 1196.6750 1196.7856 -0.1106 1 39 0.0059 2 K.LILLDKLLTR.L 21619 21620 21622 22977 627.3508 1252.6871 1252.7503 -0.0632 1 0 43 9 K.SLPAKVEQILR.V 1444 424.2784 1269.8133 1269.6870 0.1264 1 12 6.9 2 K.QYYKWILTR.N 24209 653.7941 1305.5737 1305.6789 -0.1053 1 5 13 5 K.SPLDHRSPLER.S 24208 28497 423.6142 2113.0345 2113.1320 -0.0975 1 1 27 2 K.LGEYKQPLPPLHPAVSDPR.S

332. P16402|H13_HUMAN Mass: 22336 Score: 39 Queries matched: 239 emPAI: 0.17 Histone H1.3 OS=Homo sapiens GN=HIST1H1D PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5890 540.2709 539.2636 539.3431 -0.0795 0 4 14 1 K.APKPK.A 8076 416.2402 830.4659 830.4610 0.0049 1 5 24 8

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K.AVAASKER.S 882 8100 9427 421.7605 841.5064 841.5021 0.0042 1 18 0.79 1 K.VAGAATPKK.S 8660 8666 8668 8676 8679 8682 8684 8688 8691 1120 86 9586 422.7464 843.4781 843.4450 0.0331 0 1 60 8 K.AASGEGKPK.A 1414 423.2577 844.5009 844.5018 -0.0009 0 39 0.028 1 R.SGVSLAALK.K 15177 486.7633 971.5121 971.5400 -0.0279 1 15 2.2 1 K.KAASGEGKPK.A

333. P10412|H14_HUMAN Mass: 21852 Score: 39 Queries matched: 7 emPAI: 0.18 Histone H1.4 OS=Homo sapiens GN=HIST1H1E PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8076 416.2402 830.4659 830.4610 0.0049 1 5 24 8 K.AVAASKER.S 882 8100 9586 422.7464 843.4781 843.4814 -0.0033 1 12 5 1 K.ATGAATPKK.S 1414 423.2577 844.5009 844.5018 -0.0009 0 39 0.028 1 R.SGVSLAALK.K 17688 529.2592 1056.5038 1056.5927 -0.0889 1 3 27 7 K.AASGEAKPKAK.K 17666

334. P16403|H12_HUMAN Mass: 21352 Score: 39 Queries matched: 21 emPAI: 0.18 Histone H1.2 OS=Homo sapiens GN=HIST1H1C PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8076 416.2402 830.4659 830.4610 0.0049 1 5 24 8 K.AVAASKER.S 882 8100 1414 423.2577 844.5009 844.5018 -0.0009 0 39 0.028 1 R.SGVSLAALK.K 18661 543.2744 1084.5343 1084.6604 -0.1261 1 10 4.9 1 K.AKKPAAATVTK.K 18658 18659 18660 5938 18663 18664 18665 18666

335. P68036|UB2L3_HUMAN Mass: 18021 Score: 39 Queries matched: 5 emPAI: 0.21 Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens GN=UBE2L3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15082 483.7471 965.4796 965.4818 -0.0022 1 9 6.6 1 K.NAEEFTKK.Y 15081 15084 16606 513.2340 1024.4534 1024.4713 -0.0178 0 39 0.0063 1 R.ADLAEEYSK.D 16616

336. Q9UQ80|PA2G4_HUMAN Mass: 44101 Score: 39 Queries matched: 7 emPAI: 0.18 Proliferation-associated protein 2G4 OS=Homo sapiens GN=PA2G4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9720 425.2367 848.4588 848.3810 0.0777 0 2 35 1 K.MGGDIANR.V 9735 14071 466.7569 931.4993 931.5087 -0.0094 0 31 0.052 1 K.ALLQSSASR.K 15506 492.7424 983.4703 983.4712 -0.0009 0 28 0.089 1 R.AFFSEVER.R 15508 22060 607.3002 1212.5858 1212.5002 0.0856 0 7 8.7 5 K.GDAMIMEETGK.I 22061

337. P02654|APOC1_HUMAN Mass: 9326 Score: 38 Queries matched: 5 emPAI: 0.43 Apolipoprotein C-I OS=Homo sapiens GN=APOC1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16056 502.2799 1002.5453 1002.5709 -0.0256 1 34 0.021 1 R.IKQSELSAK.M 16017 16059 17536 525.2787 1048.5428 1048.5335 0.0094 1 (0) 55 6 K.QSELSAKMR.E 18075 533.2949 1064.5753 1064.5284 0.0469 1 3 25 5 K.QSELSAKMR.E

338. Q96PE2|ARHGH_HUMAN Mass: 223645 Score: 38 Queries matched: 45 emPAI: 0.02 Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5173 505.2236 504.2164 504.2907 -0.0744 0 8 20 5 K.LASSK.S 12041 442.7568 883.4991 883.5127 -0.0136 0 27 0.11 1 K.LADILSPR.L 12019 12021 2839 12023 12024 12025 12026 2840 1202 13995 466.2297 930.4448 930.5287 -0.0839 0 3 31 9 K.EARPAFLK.F 14889 479.3055 956.5965 956.5403 0.0562 1 11 4.2 3 K.QVAERINK.G 17722 529.7494 1057.4843 1057.5880 -0.1037 1 6 18 2 R.ENIQKAISR.L 20525 574.7739 1147.5332 1147.6601 -0.1269 0 6 13 8 K.VGALLVQSFSK.D 20522 22901 416.8965 1247.6678 1247.6193 0.0485 1 4 19 10 R.CHREPPPSLR.S 23555 640.8236 1279.6327 1279.6004 0.0323 0 1 37 8 R.LSSGGGSSSETVGR.D 23744 430.1992 1287.5759 1287.7034 -0.1276 0 8 7.1 2 K.SVTLGTQGSPITK.M 24896 671.3269 1340.6393 1340.6468 -0.0076 0 4 18 8 R.TLMQGYMQPLK.Q 24886 26459 492.5766 1474.7080 1474.6630 0.0450 0 3 22 2 R.EAGHFWDPQNFK.S 26456 26460 26467 27908 476.7745 1903.0687 1902.9357 0.1330 1 2 19 3 R.RSSM SLYTAASVIDTASK.Y

339. Q86U44|MTA70_HUMAN Mass: 65175 Score: 38 Queries matched: 10 emPAI: 0.06 N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 16333 508.7607 1015.5068 1015.5410 -0.0342 1 37 0.013 2 K.QLDSLRER.L 16329 16331 16332 16334 16335 17489 524.2420 1046.4694 1046.4563 0.0131 0 5 17 6 K.ASDADRPCR.K 19827 562.2564 1122.4982 1122.5413 -0.0431 0 6 12 1 K.LSAMMGAVAEK.K 19829 20513 574.2968 1146.5791 1146.6284 -0.0493 0 10 6 2 K.FAAQELIEVK.R

340. Q5VSP4|LC1L1_HUMAN Mass: 18078 Score: 38 Queries matched: 4 emPAI: 0.21 Putative lipocalin 1-like protein 1 OS=Homo sapiens GN=LCN1L1 PE=5 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 21322 593.3299 1184.6452 1184.6765 -0.0313 0 30 0.057 1 R.GLSTESILIPR.Q 6566 21320 21321

Proteins matching the same set of peptides: P31025|LCN1_HUMAN Mass: 19409 Score: 38 Queries matched: 4 Lipocalin-1 OS=Homo sapiens GN=LCN1 PE=1 SV=1

341. P11279|LAMP1_HUMAN Mass: 45367 Score: 37 Queries matched: 2 emPAI: 0.08 Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens GN=LAMP1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7146 403.6969 805.3793 805.3930 -0.0137 0 7 15 2 K.DNTTVTR.L 20626 576.2950 1150.5755 1150.5982 -0.0227 0 37 0.0096 1 R.ALQATVGNSYK.C

342. P63220|RS21_HUMAN Mass: 9220 Score: 37 Queries matched: 9 emPAI: 1.07

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40S ribosomal protein S21 OS=Homo sapiens GN=RPS21 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5041 501.2628 500.2555 500.3322 -0.0767 0 3 1.1e+002 5 R.IIGAK.D 15988 501.2968 1000.5791 1000.5917 -0.0126 1 12 3.6 2 R.LAKADGIVSK.N 15924 15942 15986 15989 15991 16586 512.7566 1023.4986 1023.5171 -0.0185 0 24 0.21 1 K.TYAICGAIR.R 20296 569.7395 1137.4645 1137.4972 -0.0327 0 31 0.039 1 R.M GESDDSILR.L

343. P51572|BAP31_HUMAN Mass: 28031 Score: 37 Queries matched: 8 emPAI: 0.46 B-cell receptor-associated protein 31 OS=Homo sapiens GN=BCAP31 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8229 420.2299 838.4453 838.4548 -0.0096 0 29 0.055 1 R.LLEEHAK.L 10912 435.2645 868.5144 868.3814 0.1330 0 6 11 1 K.YDDVTEK.V 2264 2317 12832 451.7644 901.5143 901.5233 -0.0089 1 17 1.4 1 R.SLKADLQK.L 14397 472.7453 943.4760 943.4975 -0.0214 0 38 0.01 1 K.LDVGNAEVK.L 17497 524.2604 1046.5063 1046.5179 -0.0115 0 21 0.46 1 K.AENQVLAM R.K 20803 580.7786 1159.5427 1159.5543 -0.0116 0 6 15 2 K.LQAAVDGPMDK.K

344. P09960|LKHA4_HUMAN Mass: 69868 Score: 37 Queries matched: 6 emPAI: 0.05 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15543 493.2803 984.5461 984.5604 -0.0143 0 8 8.2 1 K.VVINGQEVK.Y 20892 582.7872 1163.5598 1163.5611 -0.0013 0 37 0.01 1 K.TFGETHPFTK.L 20891 24404 657.7734 1313.5322 1313.5372 -0.0050 0 21 0.3 1 R.DGETPDPEDPSR.K 25201 679.3074 1356.6001 1356.6894 -0.0892 0 3 25 7 K.ASM HPVTAMLVGK.D 27000 524.9302 1571.7687 1571.7692 -0.0005 1 16 1 1 K.DLAAFDKSHDQAVR.T

345. Q5T750|XP32_HUMAN Mass: 28557 Score: 37 Queries matched: 3 emPAI: 0.13 Skin-specific protein 32 OS=Homo sapiens GN=XP32 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11800 438.7439 875.4732 875.4865 -0.0133 0 14 2.6 1 R.TFGVSPLR.R 11798 26736 757.8474 1513.6802 1513.7235 -0.0433 0 37 0.0078 1 K.YQVPCQTQTYVK.C

346. Q9H972|CN093_HUMAN Mass: 59345 Score: 37 Queries matched: 9 emPAI: 0.06 Uncharacterized protein C14orf93 OS=Homo sapiens GN=C14orf93 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7071 401.2404 800.4662 800.4392 0.0270 0 37 0.015 3 R.ANNELLK.R 7063 7073 10207 430.7399 859.4652 859.5167 -0.0516 0 2 50 8 R.VLVPAYAK.Q 11907 441.1667 880.3188 880.4290 -0.1102 0 4 17 1 R.FNGSESIK.S 16460 510.2552 1018.4959 1018.5447 -0.0488 0 1 49 7 K.SSWNISVVK.F 17019 519.2582 1036.5019 1036.5301 -0.0282 1 5 16 8 K.RFNGSESIK.S 17020 30219 430.0681 2574.3648 2574.2483 0.1165 0 4 7.4 1 K.ALSAVEEECDSVGSGVQVVIEELR.Q

347. Q02413|DSG1_HUMAN Mass: 114670 Score: 37 Queries matched: 11 emPAI: 0.03 Desmoglein-1 OS=Homo sapiens GN=DSG1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7460 408.7609 815.5072 815.4752 0.0320 0 16 2 3 K.LADISLGK.E 7458 7462 14413 472.7652 943.5159 943.5702 -0.0543 1 15 2.2 7 K.KLADISLGK.E 14404 14408 14410 18794 545.2725 1088.5304 1088.5462 -0.0158 0 14 2.2 1 R.DGSNVIVTER.V 18896 546.2596 1090.5047 1090.4713 0.0334 0 3 27 7 R.EMQDLGGGER.M 19662 560.2811 1118.5476 1118.5568 -0.0092 0 37 0.012 1 R.ESSNVVVTER.V 32669 503.1036 3012.5780 3012.5992 -0.0212 1 0 15 6 R.VIAPSSSLPTSLTIHHPRESSNVVVTER.V

348. Q96QA5|GSDMA_HUMAN Mass: 49633 Score: 37 Queries matched: 3 emPAI: 0.08 Gasdermin-A OS=Homo sapiens GN=GSDMA PE=2 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14933 480.2504 958.4862 958.5083 -0.0221 0 37 0.013 1 K.ALETLQER.K 14935 16223 506.2503 1010.4860 1010.5549 -0.0689 0 9 6.3 3 K.LAADHPFLK.E

349. O14979|HNRDL_HUMAN Mass: 46580 Score: 37 Queries matched: 8 emPAI: 0.08 Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens GN=HNRPDL PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5353 516.2896 515.2823 515.3431 -0.0608 1 6 26 1 K.ALKGK.E 5366 13464 458.2578 914.5010 914.4570 0.0440 0 10 6.5 1 R.QQQQQQK.G 13954 465.7433 929.4721 929.4791 -0.0070 1 5 19 7 R.GAAAGGRGGTR.G 15632 494.7542 987.4938 987.5098 -0.0159 1 2 42 10 K.TDPVTGRSR.G 6446 584.2929 1166.5712 1166.5642 0.0070 0 30 0.12 1 R.FGEVVDCTIK.T 20950 24466 659.2909 1316.5672 1316.6320 -0.0648 1 3 25 9 K.INASKNQQDDGK.M

350. Q8NEZ4|MLL3_HUMAN Mass: 548270 Score: 36 Queries matched: 41 emPAI: 0.01 Histone-lysine N-methyltransferase MLL3 OS=Homo sapiens GN=MLL3 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5996 545.3097 544.3024 544.3584 -0.0560 0 0 2.3e+002 1 K.VVLSK.G 3 400.2064 798.3983 798.4096 -0.0113 1 3 74 1 R.APDGRQR.L 8000 415.2200 828.4254 828.4453 -0.0199 1 4 26 2 R.TGEKAAPR.S 8406 421.2345 840.4544 840.3171 0.1374 0 6 11 1 -.MSSEEDK.S 8312 8317 8333 8356 1089 8425 8472 8564 12171 444.2413 886.4680 886.5851 -0.1171 1 13 3.2 5 K.ITKVVLSK.G 2903 2904 12172 2926 12197 444.7039 887.3932 887.4600 -0.0668 0 10 6.9 4 K.DLEGVEVK.D 12907 452.7349 903.4553 903.4297 0.0256 0 36 0.015 2 K.LEEQNGSK.V 12887 12892 12893 12895 12900 12902 12903 12908 12963 453.2397 904.4649 904.4614 0.0035 0 8 9.2 2 K.AVVSGSTER.C 13412 457.7783 913.5420 913.5345 0.0076 1 1 46 3 K.QLEQIRK.Q 14393 472.7246 943.4346 943.4471 -0.0126 0 6 15 9 R.QEQQQQR.Q 14475 473.7228 945.4311 945.4087 0.0224 0 14 2.6 1 K.TGATSGCHR.F 15683 495.2753 988.5361 988.5739 -0.0378 1 0 56 4 K.MVALKGINK.V 15706 495.7814 989.5482 989.5658 -0.0176 0 1 48 7 R.SPVAPPLGPR.Y

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19246 552.7835 1103.5523 1103.5472 0.0052 1 3 30 3 K.DGASPFQRAR.K 21014 585.2846 1168.5546 1168.4376 0.1170 0 3 26 7 R.EGELMDCDGK.S 21140 589.3356 1176.6566 1176.5856 0.0711 1 (1) 41 1 R.QMQAMIRQR.S 21391 597.2275 1192.4404 1192.5805 -0.1401 1 2 21 2 R.QMQAMIRQR.S 24208 653.7900 1305.5655 1305.5659 -0.0004 0 5 12 3 R.DPYDQSPMTPR.S 25547 688.8383 1375.6621 1375.6467 0.0155 0 0 44 9 K.QISNEVDSEDLK.M

351. P19971|TYPH_HUMAN Mass: 50323 Score: 36 Queries matched: 7 emPAI: 0.07 Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7114 402.2154 802.4163 802.4185 -0.0021 0 20 0.66 1 R.LSEADIR.G 17489 524.2420 1046.4694 1046.4815 -0.0121 0 36 0.014 1 R.ALCSGSPAER.R 18647 542.7717 1083.5288 1083.5309 -0.0021 0 18 0.75 1 R.DGPALSGPQSR.A 23970 649.7959 1297.5773 1297.6812 -0.1040 0 (1) 36 5 R.MLAAQGVDPGLAR.A 24409 657.8208 1313.6270 1313.6762 -0.0491 0 7 8.8 4 R.MLAAQGVDPGLAR.A 24404 27314 824.3985 1646.7825 1646.8376 -0.0551 1 4 18 1 R.VAAALDDGSALGRFER.M

352. Q9Y305|ACOT9_HUMAN Mass: 50269 Score: 36 Queries matched: 26 emPAI: 0.07 Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens GN=ACOT9 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12701 451.2439 900.4732 900.4777 -0.0045 1 20 0.74 4 R.QGELNKGR.R 12728 16655 513.3011 1024.5875 1024.5414 0.0462 1 1 36 8 K.SQDGLPPRR.M 17663 528.7907 1055.5668 1055.6491 -0.0823 1 3 28 8 R.KLLHSFLAK.S 20465 572.8099 1143.6052 1143.6135 -0.0084 1 36 0.014 1 K.KSLSPEQDIK.F 20440 20442 20443 20449 20451 20453 20460 20464 22318 611.7982 1221.5818 1221.7081 -0.1263 1 16 1.2 2 R.RIAFSSTSLLK.M 22304 22305 22306 22310 22317 22319 22320 22323 26324 727.3300 1452.6454 1452.7838 -0.1384 1 2 23 8 K.YLTVQNTVRFGR.I 26327

353. P60866|RS20_HUMAN Mass: 13478 Score: 36 Queries matched: 3 emPAI: 0.29 40S ribosomal protein S20 OS=Homo sapiens GN=RPS20 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9639 423.7265 845.4385 845.4429 -0.0044 0 22 0.43 1 K.VCADLIR.G 9638 22883 416.5592 1246.6559 1246.6670 -0.0111 0 36 0.012 1 K.TPVEPEVAIHR.I

354. Q9BYJ4|TRI34_HUMAN Mass: 58138 Score: 36 Queries matched: 20 emPAI: 0.06 Tripartite motif-containing protein 34 OS=Homo sapiens GN=TRIM34 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 728 414.2329 826.4512 826.5388 -0.0877 1 5 34 4 K.LQAVLKR.L 7921 7958 12361 446.7464 891.4782 891.4484 0.0299 0 3 36 3 R.ACITVSNK.E 12477 448.2577 894.5007 894.4117 0.0891 0 8 7.9 3 K.EAVTSMGGK.S 12397 3050 12433 3064 3069 12907 452.7349 903.4553 903.4549 0.0004 1 36 0.015 3 R.LEEEEKK.T 12887 12892 12895 12900 12902 12903 12908 12909 12915

355. Q8NI51|CTCFL_HUMAN Mass: 77379 Score: 36 Queries matched: 13 emPAI: 0.05 Transcriptional repressor CTCFL OS=Homo sapiens GN=CTCFL PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5798 534.2989 533.2916 533.3173 -0.0257 1 1 58 1 K.AKSTK.N 6913 684.2912 683.2840 683.3351 -0.0511 1 6 29 2 R.EKDHR.S 12907 452.7349 903.4553 903.4185 0.0368 0 36 0.015 3 K.LEEEQEK.N 12887 12892 12895 12900 12902 12903 12908 12909 12911

356. O75083|WDR1_HUMAN Mass: 66836 Score: 36 Queries matched: 16 emPAI: 0.06 WD repeat-containing protein 1 OS=Homo sapiens GN=WDR1 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7038 400.7315 799.4484 799.4552 -0.0068 0 36 0.017 1 R.IAVVGEGR.E 7037 2922 444.2614 886.5083 886.5124 -0.0040 0 11 21 2 K.VINSVDIK.Q 2921 2923 2924 12623 450.2665 898.5184 898.4582 0.0601 0 6 12 1 R.YTSLM LR.D 14686 476.7355 951.4565 951.4662 -0.0097 0 13 2.6 1 R.DYSGQGVVK.L 14790 478.7601 955.5057 955.5563 -0.0506 1 10 4.9 3 K.RIAVVGEGR.E 14788 14789 14794 14795 18172 535.7534 1069.4922 1069.6132 -0.1210 1 5 16 4 R.GVSKIIGGDPK.G 18676 543.2910 1084.5674 1084.5699 -0.0025 0 9 6.5 1 K.SIQCLTVHK.N 19429 554.7743 1107.5340 1107.6539 -0.1200 0 6 14 9 R.LYSILGTTLK.D

357. Q8TES7|FBF1_HUMAN Mass: 125769 Score: 36 Queries matched: 14 emPAI: 0.03 Fas-binding factor 1 OS=Homo sapiens GN=FBF1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7443 408.7203 815.4260 815.4501 -0.0241 1 36 0.02 2 R.AELERAK.S 12002 442.6849 883.3553 883.4763 -0.1210 0 4 17 3 K.QPPVTQSK.T 14485 474.1450 946.2754 946.4355 -0.1602 0 11 1.9 1 R.ENEELSAR.Y 15383 489.2396 976.4647 976.5124 -0.0477 1 2 40 10 R.ASILDMRR.D 16623 513.2516 1024.4886 1024.4383 0.0504 0 5 15 5 R.AEEVESMSK.V 16606 16613 5296 17173 522.2743 1042.5340 1042.5883 -0.0543 1 0 54 3 K.ERINATALR.V 18920 546.8091 1091.6036 1091.5029 0.1007 1 9 7.3 6 K.DQEMERLR.E 21948 404.1670 1209.4792 1209.6353 -0.1561 0 3 22 1 R.AKPPTEGAGSPAK.A 22528 617.2844 1232.5543 1232.5931 -0.0388 1 1 42 6 K.MEARLNEQSR.L 24426 439.2314 1314.6723 1314.6602 0.0122 0 4 22 6 R.SLNSIIHQMEK.F 4085 471.2609 1410.7610 1410.6925 0.0685 0 0 1.1e+002 4 K.QSPPMASSPIQPR.K

358. Q01130|SFRS2_HUMAN Mass: 25461 Score: 36 Queries matched: 5 emPAI: 0.15 Splicing factor, arginine/serine-rich 2 OS=Homo sapiens GN=SFRS2 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6910 682.3796 681.3724 681.3446 0.0278 1 1 41 7 R.DRYTK.E 13574 459.7473 917.4800 917.4971 -0.0170 0 36 0.017 1 R.VGDVYIPR.D 3700 3701 3702

359. P36543|VATE1_HUMAN Mass: 26186 Score: 35 Queries matched: 27 emPAI: 0.15 V-type proton ATPase subunit E 1 OS=Homo sapiens GN=ATP6V1E1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide

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15701 495.7588 989.5030 989.5043 -0.0013 0 35 0.018 1 R.GALFGANANR.K 18957 547.2552 1092.4958 1092.5121 -0.0163 0 20 0.47 2 -.MALSDADVQK.Q 18955 18960 18962 18968 18969 18970 18973 18978 19435 554.8212 1107.6279 1107.5084 0.1195 0 6 13 4 K.AEEEFNIEK.G 19437 19656 559.7935 1117.5725 1117.5992 -0.0267 1 4 21 8 R.GALFGANANRK.F 19652 20503 573.8297 1145.6449 1145.6404 0.0045 1 5 15 5 K.IKVSNTLESR.L 24421 658.3296 1314.6446 1314.7143 -0.0697 1 2 29 4 M.ALSDADVQKQIK.H 27060 793.8595 1585.7045 1585.8311 -0.1266 1 3 18 6 R.ARDDLITDLLNEAK.Q 32062 475.0742 2844.4015 2844.5935 -0.1920 1 2 12 2 R.YQVLLDGLVLQGLYQLLEPRM IVR.C

360. Q9HBG4|VPP4_HUMAN Mass: 97207 Score: 35 Queries matched: 8 emPAI: 0.04 V-type proton ATPase 116 kDa subunit a isoform 4 OS=Homo sapiens GN=ATP6V0A4 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12410 448.2013 894.3881 894.4382 -0.0501 1 11 4 8 K.KICDGFR.A 12406 3676 459.2463 916.4780 916.5090 -0.0310 1 4 1e+002 6 R.KSQLQASR.I 18436 538.7574 1075.5002 1075.5332 -0.0329 0 35 0.016 1 R.EMLESVNVR.L 18438 24199 653.3344 1304.6543 1304.6897 -0.0354 0 15 1.4 1 R.EMITLETVLEK.L 24198 24200

361. Q9NQW7|XPP1_HUMAN Mass: 70558 Score: 35 Queries matched: 12 emPAI: 0.05 Xaa-Pro aminopeptidase 1 OS=Homo sapiens GN=XPNPEP1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7444 408.7256 815.4367 815.4501 -0.0134 1 11 6.4 2 K.DKVADLR.L 8233 420.7228 839.4310 839.4541 -0.0231 0 4 18 4 R.YFLQAAK.Q 20746 579.2984 1156.5823 1156.6240 -0.0417 0 1 40 9 R.QEALEWLIR.E 20939 583.2983 1164.5820 1164.6026 -0.0206 0 35 0.015 1 K.ASYAVSETIPK.D 23433 635.8186 1269.6227 1269.7115 -0.0888 1 7 9.5 3 -.MPPKVTSELLR.Q 23423 23425 23427 23428 23430 23432 23434

362. P62899|RL31_HUMAN Mass: 14454 Score: 35 Queries matched: 1 emPAI: 0.27 60S ribosomal protein L31 OS=Homo sapiens GN=RPL31 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15634 494.7667 987.5189 987.5349 -0.0160 0 35 0.02 1 R.SAINEVVTR.E

363. P62906|RL10A_HUMAN Mass: 24987 Score: 35 Queries matched: 13 emPAI: 0.33 60S ribosomal protein L10a OS=Homo sapiens GN=RPL10A PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7359 406.2496 810.4847 810.4963 -0.0116 0 33 0.024 2 R.ILGPGLNK.A 7351 7356 265 7360 12920 452.7443 903.4741 903.4596 0.0145 0 (0) 62 4 K.STMGKPQR.L 13669 460.7347 919.4549 919.4545 0.0004 0 5 19 3 K.STM GKPQR.L 15080 483.7437 965.4728 965.4818 -0.0089 0 31 0.043 1 R.DTLYEAVR.E 15075 15078 24199 653.3344 1304.6543 1304.7928 -0.1385 1 10 4.5 5 K.QIPRILGPGLNK.A 24198 24200

364. P01023|A2MG_HUMAN Mass: 164614 Score: 35 Queries matched: 18 emPAI: 0.02 Alpha-2-macroglobulin OS=Homo sapiens GN=A2M PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7154 403.7093 805.4041 805.3970 0.0071 0 22 0.47 1 K.GPTQEFK.K 7964 414.2407 826.4669 826.3895 0.0775 1 13 2.7 9 R.KEYEMK.L 7978 414.7392 827.4638 827.4501 0.0137 0 8 10 1 K.SDIAPVAR.L 1796 432.2419 862.4693 862.5276 -0.0583 1 2 2.1e+002 2 K.TKVFQLK.R 12120 443.7260 885.4373 885.4345 0.0029 0 30 0.066 1 K.YGAATFTR.T 13806 463.2797 924.5448 924.5393 0.0055 0 19 0.63 1 R.TGTHGLLVK.Q 16130 503.7442 1005.4738 1005.4628 0.0110 0 19 0.69 1 K.FQVDNNNR.L 16120 16121 16126 16127 16129 16134 16135 16371 509.2886 1016.5627 1016.5502 0.0125 1 19 0.82 2 K.SLNEEAVKK.D 18641 542.7560 1083.4974 1083.6077 -0.1102 0 8 9.2 2 K.GHFSISIPVK.S 22411 614.8102 1227.6059 1227.6142 -0.0083 1 6 14 3 K.MLERSNHVSR.T 23031 628.3254 1254.6363 1254.6357 0.0007 0 35 0.016 1 K.AIGYLNTGYQR.Q

365. P0C869|PA24B_HUMAN Mass: 89093 Score: 35 Queries matched: 3 emPAI: 0.04 Cytosolic phospholipase A2 beta OS=Homo sapiens GN=PLA2G4B PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7938 414.2241 826.4336 826.5025 -0.0688 0 4 20 3 K.QVVAAALR.Q 10242 431.6728 861.3311 861.4742 -0.1431 0 6 18 1 R.TCLLTVR.V 15173 486.7502 971.4859 971.5148 -0.0289 1 35 0.021 2 R.QELAERAR.L

366. O75608|LYPA1_HUMAN Mass: 24996 Score: 35 Queries matched: 3 emPAI: 0.33 Acyl-protein thioesterase 1 OS=Homo sapiens GN=LYPLA1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13459 458.2532 914.4919 914.5073 -0.0154 0 31 0.047 1 K.ALIDQEVK.N 21793 602.3247 1202.6349 1202.6659 -0.0310 0 16 1.3 1 K.TLVNPANVTFK.T 23447 636.3148 1270.6149 1270.6418 -0.0269 0 33 0.022 1 R.ASFPQGPIGGANR.D

367. Q96TA1|NIBL1_HUMAN Mass: 83144 Score: 35 Queries matched: 20 emPAI: 0.14 Niban-like protein 1 OS=Homo sapiens GN=FAM129B PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8007 415.2291 828.4436 828.4454 -0.0017 0 31 0.055 1 R.LDGLQQR.F 8003 8004 10006 428.7499 855.4852 855.4814 0.0038 1 32 0.035 1 R.KVPLDER.I 10977 435.7139 869.4132 869.3412 0.0721 0 7 9.8 4 -.MGWMGEK.T 10981 12058 443.2147 884.4149 884.3949 0.0200 0 8 9.3 2 K.LGEYMEK.L 2846 2850 2851 2857 13713 461.7491 921.4837 921.4920 -0.0083 0 16 1.2 1 R.AVINSAGYK.I 18897 546.2652 1090.5158 1090.4567 0.0591 0 4 21 1 K.YDYDSSSVR.K 19610 558.7790 1115.5435 1115.5499 -0.0064 0 26 0.14 1 R.FDVSSTSVFK.Q 19614 20620 576.2753 1150.5361 1150.5540 -0.0179 0 (8) 7.8 3 R.TDMDQIITSK.E 20622 20624 20956 584.3385 1166.6625 1166.5489 0.1136 0 9 5.8 1 R.TDM DQIITSK.E 25876 700.8293 1399.6440 1399.7096 -0.0656 1 1 37 4 R.FDVSSTSVFKQR.A

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368. P49913|CAMP_HUMAN Mass: 19517 Score: 35 Queries matched: 2 emPAI: 0.20 Cathelicidin antimicrobial peptide OS=Homo sapiens GN=CAMP PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12126 443.7358 885.4571 885.4668 -0.0097 0 24 0.29 1 R.AIDGINQR.S 3796 463.2174 924.4203 924.4301 -0.0098 0 35 0.052 1 R.SSDANLYR.L

369. P42226|STAT6_HUMAN Mass: 94816 Score: 34 Queries matched: 10 emPAI: 0.04 Signal transducer and activator of transcription 6 OS=Homo sapiens GN=STAT6 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7412 408.2237 814.4327 814.4548 -0.0221 0 10 7 7 R.QILQGEK.K 7410 7414 14362 472.2709 942.5272 942.5498 -0.0226 1 3 27 5 R.QILQGEKK.A 20898 582.8011 1163.5875 1163.5605 0.0271 1 32 0.03 2 R.ADMVTEKQAR.E 20894 20895 20896 20897 20899

370. P61160|ARP2_HUMAN Mass: 45017 Score: 34 Queries matched: 8 emPAI: 0.08 Actin-related protein 2 OS=Homo sapiens GN=ACTR2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7041 400.7395 799.4644 799.4664 -0.0020 1 21 0.57 1 R.RLDIAGR.D 7039 7042 2922 444.2614 886.5083 886.5124 -0.0040 1 34 0.1 1 R.VLKGDVEK.L 2921 2923 4973 498.2697 994.5249 994.5560 -0.0310 1 4 52 3 K.IRIEDPPR.R 23852 647.8149 1293.6153 1293.6388 -0.0234 0 3 23 1 K.VVVCDNGTGFVK.C

371. Q99436|PSB7_HUMAN Mass: 30288 Score: 34 Queries matched: 14 emPAI: 0.12 Proteasome subunit beta type-7 OS=Homo sapiens GN=PSMB7 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13651 460.2589 918.5032 918.5022 0.0010 0 34 0.026 1 K.GTTAVLTEK.I 13629 13632 16498 510.7663 1019.5180 1019.4957 0.0222 0 9 8.3 3 R.ATEGMVVADK.N 16492 5272 16494 16496 16497 5273 5274 16499 1650

372. Q0VF96|CGNL1_HUMAN Mass: 149525 Score: 34 Queries matched: 22 emPAI: 0.02 Cingulin-like protein 1 OS=Homo sapiens GN=CGNL1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7582 411.7036 821.3926 821.4429 -0.0503 1 7 11 10 K.SRLTAMK.M 7573 1401 423.2060 844.3975 844.4290 -0.0315 0 11 17 5 R.IAELEDR.L 9601 12383 447.7362 893.4578 893.4606 -0.0029 1 34 0.024 1 K.KYEGEIR.Q 12382 12385 3546 455.2272 908.4399 908.4716 -0.0316 0 11 7.7 1 K.AGSYGVSIR.V 14088 467.2593 932.5041 932.4927 0.0114 1 2 42 5 K.TLEAEKSR.L 15888 500.2630 998.5114 998.4893 0.0221 1 10 5.3 1 R.NRINPDDR.K 15886 16862 516.7913 1031.5680 1031.5182 0.0498 1 9 8.2 7 R.RELAEMQR.Q 16922 517.2663 1032.5181 1032.4836 0.0346 1 5 18 7 R.LESEERDR.A 17487 524.2395 1046.4645 1046.4992 -0.0347 0 15 1.8 1 R.NNSDLLSER.I 17852 531.2595 1060.5045 1060.5036 0.0008 0 3 26 5 R.LEESEGELR.K 18727 544.2993 1086.5841 1086.5822 0.0020 0 8 9.5 6 R.IIHLEGSYR.S 19657 559.7940 1117.5735 1117.5615 0.0121 0 13 2.9 5 K.TLTEEGINNK.K 19653 20513 574.2968 1146.5791 1146.5815 -0.0023 1 4 22 6 R.MRANLEELR.S 20903 583.2291 1164.4437 1164.6251 -0.1814 0 10 4.3 1 R.QLEEALVHAR.K 21283 592.7750 1183.5355 1183.6812 -0.1457 0 2 33 4 K.GALIEELLQAK.Q 26143 714.8331 1427.6517 1427.7117 -0.0600 1 6 12 9 R.QDSAGPVLDGARSR.R

373. P13798|ACPH_HUMAN Mass: 82142 Score: 34 Queries matched: 11 emPAI: 0.09 Acylamino-acid-releasing enzyme OS=Homo sapiens GN=APEH PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11781 438.2548 874.4951 874.4913 0.0039 0 28 0.11 1 K.VGFLPSAGK.E 11776 11777 12773 451.7402 901.4659 901.4141 0.0518 0 1 53 3 K.AGGTGPGEEK.Q 14821 479.2351 956.4557 956.4603 -0.0046 0 7 11 1 K.AESFFQTK.A 21008 585.2648 1168.5151 1168.6816 -0.1665 0 9 5.5 2 K.VTSVVVDVVPR.Q 21000 21007 23574 641.7903 1281.5660 1281.6904 -0.1243 0 1 34 7 K.MGFAVLLVNYR.G 23571 25325 681.3207 1360.6269 1360.6470 -0.0201 0 29 0.059 1 K.ALDVSASDDEIAR.L

374. Q9HB71|CYBP_HUMAN Mass: 26308 Score: 34 Queries matched: 8 emPAI: 0.14 Calcyclin-binding protein OS=Homo sapiens GN=CACYBP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 398 411.2375 820.4604 820.4695 -0.0090 0 17 2.6 1 R.SFDLLVK.N 389 14517 474.2699 946.5252 946.5335 -0.0083 1 21 0.45 1 K.SKIETEIK.N 15275 487.7532 973.4919 973.5444 -0.0524 1 10 6.2 3 K.IETEIKNK.M 18877 545.7957 1089.5768 1089.5852 -0.0084 0 34 0.027 1 K.TDTVLILCR.K 24979 448.8600 1343.5582 1343.5551 0.0031 1 8 6.3 1 K.KIYEDGDDDMK.R 24978 24982

375. Q92616|GCN1L_HUMAN Mass: 294953 Score: 33 Queries matched: 31 emPAI: 0.01 Translational activator GCN1 OS=Homo sapiens GN=GCN1L1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 50 402.2125 802.4105 802.3933 0.0172 0 5 96 3 K.ALQDSNR.G 7111 8205 419.7469 837.4792 837.4232 0.0560 0 1 37 6 K.QVFTSEK.F 8195 8211 9810 426.2424 850.4702 850.4259 0.0444 0 6 14 4 R.FTMEVPK.K 12253 444.7446 887.4746 887.4964 -0.0218 0 11 5.1 6 R.EILSELGK.C 12223 13772 462.7146 923.4146 923.5189 -0.1043 1 4 22 8 K.HAVDGAVKK.L 14941 480.2695 958.5245 958.5270 -0.0025 0 11 5.1 8 R.CGLALALNK.L 15441 490.2955 978.5765 978.5321 0.0445 0 6 13 4 R.VLAGLYMGR.S 15439 17208 522.7991 1043.5836 1043.5975 -0.0139 1 8 8.2 6 R.REILSELGK.C 19596 558.3001 1114.5857 1114.5843 0.0014 1 12 3.4 4 K.ALQDSNRGVR.L 22879 624.3212 1246.6279 1246.6955 -0.0676 0 33 0.023 2 R.QSVVVLMGSLAK.H 23425 635.8108 1269.6071 1269.7809 -0.1738 1 10 4.5 1 K.SRVVLPYLVPK.L 23423 23424 23426 23427 23428 23429 23430 23432 2706 439.8485 1316.5235 1316.6936 -0.1701 0 3 25 1 K.SIIQSAQQDSIK.K 24504 660.7910 1319.5675 1319.6907 -0.1232 1 2 31 6 R.MKIDPEAFITR.H 25183 452.5854 1354.7344 1354.8435 -0.1091 0 2 28 6 K.AALLETLSLLLAK.V 26829 510.6098 1528.8076 1528.8534 -0.0459 1 2 26 1 K.LEKLMPEIVATASK.V 28422 415.5897 2072.9123 2073.0776 -0.1653 1 0 25 2 R.SGAAQGLAEVM AGLGVEKLEK.L

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376. Q15404|RSU1_HUMAN Mass: 31521 Score: 33 Queries matched: 14 emPAI: 0.12 Ras suppressor protein 1 OS=Homo sapiens GN=RSU1 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12499 449.2260 896.4374 896.5555 -0.1181 1 8 7 1 R.KPLAAKNR.- 12500 12504 14752 477.7747 953.5349 953.4865 0.0485 0 8 8.1 1 K.HLNLGMNR.L 16281 507.7487 1013.4828 1013.5393 -0.0565 0 20 0.52 2 R.DNDLISLPK.E 16269 5333 515.7934 1029.5722 1029.5706 0.0016 0 33 0.027 1 K.EIGELTQLK.E 5332 21300 592.8115 1183.6085 1183.7652 -0.1567 1 7 11 9 K.LTKLQILSLR.D 21290 21291 21296 21299 21972 606.3298 1210.6451 1210.6604 -0.0153 1 0 40 9 K.LKHLNLGMNR.L

377. Q99798|ACON_HUMAN Mass: 86113 Score: 33 Queries matched: 10 emPAI: 0.04 Aconitate hydratase, mitochondrial OS=Homo sapiens GN=ACO2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12047 442.7600 883.5055 883.5603 -0.0548 1 5 14 5 R.LQKALGVR.Q 12022 12035 12051 13712 461.7442 921.4738 921.4668 0.0070 0 12 3.1 1 R.EHAALEPR.H 3958 468.2424 934.4702 934.4872 -0.0170 0 33 0.076 1 R.DGYAQILR.D 21058 588.2723 1174.5300 1174.6571 -0.1270 1 6 13 3 K.SYLRLRPDR.V 21054 21621 599.3448 1196.6750 1196.5925 0.0825 0 9 5.4 9 R.LEAPDADELPK.G 21586

378. P30046|DOPD_HUMAN Mass: 12818 Score: 33 Queries matched: 15 emPAI: 0.31 D-dopachrome decarboxylase OS=Homo sapiens GN=DDT PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10588 435.2467 868.4789 868.5130 -0.0341 1 11 3.4 1 R.VPAGLEKR.L 10683 10792 10810 10881 10941 10963 11926 441.2494 880.4843 880.4728 0.0114 0 9 5.3 1 K.IGTVMTFL.- 11917 11919 2787 11939 2796 12684 451.2334 900.4522 900.4665 -0.0142 0 33 0.035 1 K.ELALGQDR.I 12688

379. Q5TZA2|CROCC_HUMAN Mass: 228787 Score: 33 Queries matched: 38 emPAI: 0.02 Rootletin OS=Homo sapiens GN=CROCC PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5107 503.2775 502.2702 502.2499 0.0203 0 10 27 3 K.AEAGR.V 6522 589.2848 588.2775 588.3231 -0.0456 0 7 39 3 R.TLEAR.E 7450 408.7341 815.4536 815.4249 0.0287 1 2 43 10 K.LQDERR.L 9582 422.7207 843.4268 843.4450 -0.0182 0 13 3.5 3 R.LEQEVAR.Q 9583 12305 445.7355 889.4564 889.4253 0.0310 0 8 11 3 R.SAQAQTER.T 12647 450.7281 899.4416 899.4937 -0.0521 1 9 7.5 4 R.RLQEQAR.D 12807 451.7566 901.4986 901.4981 0.0005 1 3 35 2 R.QALSEARK.Q 13398 457.7694 913.5242 913.5232 0.0009 0 33 0.028 1 K.LALLEEAR.T 13445 458.2416 914.4687 914.5046 -0.0358 1 14 2.6 1 K.SALQGRQR.Q 13882 464.7522 927.4898 927.5137 -0.0239 0 6 13 2 R.QLAQLEAR.R 13921 465.2539 928.4933 928.4978 -0.0045 0 3 29 9 R.AEAAELGLR.L 13891 14003 466.2366 930.4586 930.5022 -0.0436 0 2 37 3 K.AEVAEALTK.A 14408 472.7630 943.5115 943.4974 0.0140 0 14 2.6 7 R.QLEQLEGK.R 15163 486.2741 970.5337 970.5196 0.0141 0 13 2.8 6 R.QELQVAQR.K 15186 486.7765 971.5385 971.5287 0.0098 0 2 39 3 R.ALAQLEAEK.R 4933 495.2772 988.5398 988.4825 0.0573 0 5 39 6 K.VEESEGALR.D 15960 501.2833 1000.5521 1000.5553 -0.0031 1 1 46 2 R.LEKQNLEK.D 15955 16475 510.2994 1018.5843 1018.5196 0.0648 1 5 18 8 R.KVTNDWTR.C 18192 536.2502 1070.4858 1070.5832 -0.0975 0 8 8 9 R.AQLQSQLQR.E 20738 579.2905 1156.5665 1156.6200 -0.0535 1 7 9.2 3 R.LLEDARDGLR.R 20735 20747 21061 588.2799 1174.5453 1174.6306 -0.0852 1 11 4.3 4 R.TLSEEATRLR.L 21355 595.2814 1188.5483 1188.5986 -0.0503 1 5 19 3 K.DQVNKDLTEK.L 21351 21356 21870 603.8088 1205.6031 1205.6438 -0.0407 1 17 1.1 3 K.TALSEKLMGTR.H 22323 611.8088 1221.6030 1221.6387 -0.0357 1 (15) 1.5 4 K.TALSEKLMGTR.H 22321 879 416.1560 1245.4462 1245.6248 -0.1786 1 3 1.8e+002 2 R.QLQVQDMRGR.Y 22969 626.7896 1251.5646 1251.6684 -0.1038 1 6 12 7 R.GLSGQRTPSPPR.R 25226 453.5656 1357.6749 1357.6837 -0.0088 0 7 11 1 R.QEGEAAALNTVQK.L 25224 26927 774.8582 1547.7019 1547.8056 -0.1036 1 5 14 9 K.YNAVSERLEQALR.L 26925

380. P12004|PCNA_HUMAN Mass: 29092 Score: 33 Queries matched: 21 emPAI: 0.13 Proliferating cell nuclear antigen OS=Homo sapiens GN=PCNA PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7045 400.7607 799.5069 799.5167 -0.0098 1 11 5.7 10 K.KVLEALK.D 10144 429.2748 856.5351 856.5382 -0.0031 0 16 1.6 1 R.LVQGSILK.K 10143 2839 442.7525 883.4905 883.4586 0.0320 0 (6) 11 3 K.IADMGHLK.Y 12021 12026 12027 12038 12040 12045 12046 12052 2910 444.2402 886.4658 886.3742 0.0915 0 8 43 4 K.VSDYEMK.L 2899 2902 2906 2928 12655 450.7618 899.5091 899.4535 0.0557 0 7 12 6 K.IADMGHLK.Y 15267 487.7137 973.4128 973.4141 -0.0013 0 33 0.034 1 R.SEGFDTYR.C 25312 680.8554 1359.6961 1359.7874 -0.0913 1 11 4 2 M.FEARLVQGSILK.K 3736 461.2158 1380.6255 1380.6741 -0.0486 0 1 1.9e+002 7 R.NLAMGVNLTSMSK.I

381. P61970|NTF2_HUMAN Mass: 14640 Score: 33 Queries matched: 2 emPAI: 0.27 Nuclear transport factor 2 OS=Homo sapiens GN=NUTF2 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13647 460.2549 918.4952 918.5175 -0.0222 0 30 0.057 1 K.LSSLPFQK.I 13648

382. Q8N335|GPD1L_HUMAN Mass: 39021 Score: 33 Queries matched: 3 emPAI: 0.10 Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens GN=GPD1L PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10227 431.2155 860.4164 860.4491 -0.0327 0 33 0.037 1 K.TIEELEK.E 10226 18702 543.8249 1085.6353 1085.6444 -0.0092 1 1 45 9 K.LISDIIREK.M

383. P14324|FPPS_HUMAN Mass: 48758 Score: 33 Queries matched: 6 emPAI: 0.08 Farnesyl pyrophosphate synthetase OS=Homo sapiens GN=FDPS PE=1 SV=4

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15000 481.2438 960.4731 960.5757 -0.1025 0 4 27 9 R.GLTVVVAFR.E 16018 502.2497 1002.4849 1002.4982 -0.0133 0 33 0.032 1 K.IGTDIQDNK.C 16025 21369 595.8194 1189.6243 1189.6343 -0.0099 0 26 0.12 1 R.ATPEQYQILK.E 21368 21370

384. Q9Y5K8|VATD_HUMAN Mass: 28245 Score: 33 Queries matched: 2 emPAI: 0.13 V-type proton ATPase subunit D OS=Homo sapiens GN=ATP6V1D PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 14346 472.2326 942.4506 942.5498 -0.0992 1 9 7.5 1 R.GGEQLAKLK.R 16991 518.7736 1035.5327 1035.5236 0.0090 0 33 0.03 1 R.EAAFSLAEAK.F

385. Q08211|DHX9_HUMAN Mass: 142181 Score: 33 Queries matched: 13 emPAI: 0.05 ATP-dependent RNA helicase A OS=Homo sapiens GN=DHX9 PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5080 502.2672 501.2600 501.2911 -0.0311 0 7 20 1 R.GANLK.D 14015 466.2516 930.4886 930.5134 -0.0248 0 23 0.3 1 R.ISAVSVAER.V 14003 14954 480.6951 959.3757 959.4784 -0.1027 1 7 12 1 K.KDAQSNAAR.D 16018 502.2497 1002.4849 1002.5862 -0.1013 0 3 26 10 R.LGGIGQFLAK.A 18068 533.2685 1064.5224 1064.5172 0.0052 0 5 16 4 R.LSMSQLNEK.E 18392 538.2677 1074.5208 1074.5458 -0.0250 0 30 0.056 1 K.LAQFEPSQR.Q 18398 18639 542.7501 1083.4857 1083.5098 -0.0241 0 1 38 2 R.AGYGAGVGGGYR.G 21062 588.2930 1174.5714 1174.5982 -0.0269 0 15 1.8 1 R.DVVQAYPEVR.I 22238 406.9062 1217.6968 1217.6040 0.0928 1 4 23 6 R.VAFERGEEPGK.S 23749 644.8324 1287.6503 1287.6969 -0.0466 0 21 0.34 2 K.LAAQSCALSLVR.Q 3105 448.9128 1343.7165 1343.6768 0.0397 1 2 29 1 R.YGDGPRPPKMAR.Y

386. P59665|DEF1_HUMAN Mass: 10536 Score: 32 Queries matched: 1 emPAI: 0.38 Neutrophil defensin 1 OS=Homo sapiens GN=DEFA1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15556 493.7472 985.4798 985.5015 -0.0217 0 32 0.033 1 R.IPACIAGER.R

Proteins matching the same set of peptides: P59666|DEF3_HUMAN Mass: 10580 Score: 32 Queries matched: 1 Neutrophil defensin 3 OS=Homo sapiens GN=DEFA3 PE=1 SV=1

387. P30153|2AAA_HUMAN Mass: 66065 Score: 32 Queries matched: 3 emPAI: 0.06 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens GN=PPP2R1A PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15465 491.2347 980.4548 980.5113 -0.0565 1 3 27 7 R.VRYMVADK.F 20804 580.7842 1159.5538 1159.5721 -0.0183 0 32 0.033 1 K.LTQDQDVDVK.Y 22804 621.8405 1241.6664 1241.7343 -0.0679 0 13 2.6 1 K.LSTIALALGVER.T

388. P18583|SON_HUMAN Mass: 264079 Score: 32 Queries matched: 24 emPAI: 0.01 Protein SON OS=Homo sapiens GN=SON PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5697 530.1492 529.1419 529.3224 -0.1805 0 6 20 3 R.ALAQK.R 5708 7052 400.7694 799.5242 799.4552 0.0690 0 12 4.5 5 K.GLVAVGER.A 1761 431.7332 861.4517 861.4344 0.0173 0 7 13 5 R.LAQDPYR.L 1764 431.7377 861.4608 861.4821 -0.0212 1 7 14 6 R.IAPRSYR.I 1762 12082 443.2457 884.4769 884.5331 -0.0562 0 1 40 6 K.AQLLEIAK.A 17686 529.2550 1056.4955 1056.4038 0.0917 0 1 48 6 R.SM MSPMADR.S 20509 574.2499 1146.4852 1146.5404 -0.0553 0 3 28 7 K.SVESTSPEPSK.I 20709 578.8157 1155.6168 1155.6135 0.0033 0 32 0.035 1 R.SLPNEEIVQK.I 20707 20708 20710 20711 24695 444.8594 1331.5565 1331.5784 -0.0219 1 2 32 5 R.RSMMMSYAAER.S 25989 707.7811 1413.5477 1413.6744 -0.1268 0 2 21 6 K.HPVSALM EICNK.R 27493 853.4014 1704.7882 1704.8583 -0.0701 1 13 1.7 2 R.LAQDPYRLAQDPYR.L 27486 27487 27488 27489 27491 27492 27494

389. Q8NFY4|SEM6D_HUMAN Mass: 121050 Score: 32 Queries matched: 7 emPAI: 0.03 Semaphorin-6D OS=Homo sapiens GN=SEMA6D PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3016 446.2353 890.4561 890.3739 0.0822 0 3 1.2e+002 1 K.SMVMDHR.G 13658 460.7090 919.4034 919.4736 -0.0702 1 0 52 6 K.AHGHGASRK.E 15147 485.7656 969.5167 969.4767 0.0400 0 7 9.9 3 K.ELPPNGDTK.S 17176 522.2748 1042.5350 1042.6386 -0.1036 1 32 0.037 1 K.KVISLQLDK.D 17172 21165 589.7705 1177.5264 1177.6455 -0.1191 0 2 38 7 K.LQNIDHPLTK.S 26986 783.8655 1565.7164 1565.7395 -0.0231 0 0 36 8 R.DQVYTVNLNEMPK.T

390. Q5VWK0|NBPF6_HUMAN Mass: 72936 Score: 32 Queries matched: 5 emPAI: 0.05 Neuroblastoma breakpoint family member 6 OS=Homo sapiens GN=NBPF6 PE=2 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11999 442.2635 882.5124 882.4559 0.0565 0 2 29 1 K.VQESPAPR.E 15430 490.2298 978.4451 978.4328 0.0123 0 7 10 10 R.DELQSMEK.L 20781 580.2475 1158.4805 1158.5881 -0.1076 0 31 0.039 1 M.VVSADPLSSER.A 20779 20780

Proteins matching the same set of peptides: Q86XG9|NBPF5_HUMAN Mass: 40750 Score: 32 Queries matched: 5 Neuroblastoma breakpoint family member 5 OS=Homo sapiens GN=NBPF5 PE=2 SV=2

391. P62851|RS25_HUMAN Mass: 13791 Score: 32 Queries matched: 7 emPAI: 1.12 40S ribosomal protein S25 OS=Homo sapiens GN=RPS25 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 9757 425.7358 849.4570 849.4708 -0.0139 0 20 0.7 1 R.AQVIYTR.N 9754 9759 15186 486.7765 971.5385 971.5651 -0.0266 0 21 0.52 1 R.AALQELLSK.G 18367 538.2487 1074.4827 1074.6073 -0.1246 0 7 12 3 K.LNNLVLFDK.A 5933 542.8109 1083.6072 1083.6288 -0.0216 0 27 0.12 1 K.LITPAVVSER.L

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23458 637.2958 1272.5771 1272.5582 0.0189 1 5 16 1 R.NTKGGDAPAAGEDA.-

392. Q99536|VAT1_HUMAN Mass: 42122 Score: 32 Queries matched: 7 emPAI: 0.19 Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens GN=VAT1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6592 597.3030 596.2958 596.3282 -0.0324 0 1 91 7 K.HEALK.E 7179 404.1694 806.3242 806.3956 -0.0714 1 6 14 2 K.QMQEKK.N 14681 476.2933 950.5721 950.5801 -0.0080 0 28 0.086 1 K.VLLVPGPEK.E 21474 597.8316 1193.6487 1193.6656 -0.0169 1 24 0.18 1 K.VLLVPGPEKEN.- 21464 21466 21473

393. Q9BUL8|PDC10_HUMAN Mass: 24686 Score: 32 Queries matched: 3 emPAI: 0.15 Programmed cell death protein 10 OS=Homo sapiens GN=PDCD10 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 18239 536.8039 1071.5933 1071.6036 -0.0103 0 32 0.05 1 R.VNLSAAQTLR.A 19199 552.2440 1102.4734 1102.4457 0.0277 1 2 35 10 M.RMTMEEMK.N 26877 770.8785 1539.7423 1539.8256 -0.0833 1 0 42 4 K.QILSKIPDEINDR.V

394. Q01968|OCRL_HUMAN Mass: 105392 Score: 32 Queries matched: 23 emPAI: 0.04 Inositol polyphosphate 5-phosphatase OCRL-1 OS=Homo sapiens GN=OCRL PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6719 614.3161 613.3088 613.3911 -0.0823 0 1 1.1e+002 4 K.VQLVR.L 79 403.2808 804.5471 804.3977 0.1494 1 1 1.7e+002 6 R.EKEASNK.E 2163 433.2623 864.5100 864.4487 0.0613 1 0 1.4e+002 4 K.VTNTMRK.L 11630 437.1732 872.3319 872.4505 -0.1185 0 3 32 5 R.VQGDWIR.E 19725 561.2727 1120.5309 1120.6968 -0.1659 1 13 3 4 R.EGLIKHILAK.R 19763 19766 20763 579.7821 1157.5496 1157.5941 -0.0445 1 27 0.1 1 R.VQGDWIRER.R 20755 20756 20758 20759 20760 20761 20762 20764 20950 584.2881 1166.5617 1166.6084 -0.0467 1 3 23 5 R.REFVFENVK.F

395. Q7Z494|NPHP3_HUMAN Score: 32 Queries matched: 16 Nephrocystin-3 OS=Homo sapiens GN=NPHP3 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7234 404.2251 806.4357 806.4068 0.0289 1 7 13 10 K.RSLEMR.E 7205 7212 7224 7231 7240 7241 11002 435.7502 869.4857 869.4290 0.0568 1 7 8.9 2 K.LERHCR.S 11003 11015 12701 451.2439 900.4732 900.4777 -0.0045 1 10 6.8 6 R.AGRAGNLDK.I 15995 501.7605 1001.5064 1001.5505 -0.0441 1 32 0.045 2 R.ELESKLQR.L 17497 524.2604 1046.5063 1046.5244 -0.0180 1 1 49 8 R.EAKLDTENK.R 21362 595.3002 1188.5857 1188.5523 0.0334 1 6 12 7 R.AATFEHDRDK.V 21358 27235 811.8536 1621.6925 1621.7835 -0.0910 0 2 20 9 K.QDILGFENTDLETK.D

396. P14174|MIF_HUMAN Mass: 12639 Score: 32 Queries matched: 2 emPAI: 0.31 Macrophage migration inhibitory factor OS=Homo sapiens GN=MIF PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 10044 428.7565 855.4984 855.4926 0.0058 1 12 3.4 6 R.LRISPDR.V 17202 522.7861 1043.5577 1043.5797 -0.0220 0 32 0.04 1 K.LLCGLLAER.L

397. Q9Y5W7|SNX14_HUMAN Mass: 111081 Score: 32 Queries matched: 7 emPAI: 0.03 Sorting nexin-14 OS=Homo sapiens GN=SNX14 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 8601 421.2565 840.4984 840.5433 -0.0448 1 32 0.034 1 K.IIKSVPGK.L 1077 8612 16685 514.2631 1026.5117 1026.6801 -0.1684 0 5 15 5 R.LVSLITLLR.D 6638 602.3033 1202.5919 1202.6547 -0.0627 0 0 2e+002 7 R.IAEGPYIDVVK.L 767 415.1362 1242.3868 1242.5438 -0.1570 0 3 27 1 K.TYCLDESIDK.I 769

398. P14314|GLU2B_HUMAN Mass: 60357 Score: 32 Queries matched: 5 emPAI: 0.06 Glucosidase 2 subunit beta OS=Homo sapiens GN=PRKCSH PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15860 499.2680 996.5214 996.4988 0.0226 1 8 8.4 2 R.EAKEQHQK.L 4987 16540 511.7493 1021.4841 1021.4828 0.0013 1 10 5 1 R.NKFEEAER.S 17203 522.7867 1043.5588 1043.6015 -0.0427 1 9 7.5 3 K.KILIEDWK.K 24426 439.2314 1314.6723 1314.6779 -0.0056 1 32 0.036 1 R.TVKEEAEKPER.E

399. Q9NUQ3|TXLNG_HUMAN Mass: 61061 Score: 31 Queries matched: 29 emPAI: 0.06 Gamma-taxilin OS=Homo sapiens GN=TXLNG PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5935 543.2507 542.2434 542.3540 -0.1106 0 6 35 5 K.AILAR.S 6370 572.3152 571.3080 571.3693 -0.0614 0 3 46 5 K.ALQIK.L 12176 444.2451 886.4757 886.4621 0.0136 1 11 5.8 1 R.VEEAARGR.G 16096 503.2264 1004.4383 1004.5654 -0.1271 0 20 0.63 2 K.LIEQYALR.E 16092 16093 16094 16095 16097 16098 16099 16100 16 20118 567.2733 1132.5321 1132.6604 -0.1283 1 31 0.039 2 K.KLIEQYALR.E 20111 20113 20114 20115 20121 20122 20124 20126 20536 575.2609 1148.5073 1148.5608 -0.0535 1 5 16 10 -.MATRVEEAAR.G 25540 687.8603 1373.7060 1373.6284 0.0777 1 9 6.4 1 R.GGGAEEATEAGRGGR.R

400. Q71UM5|RS27L_HUMAN Mass: 9813 Score: 31 Queries matched: 2 emPAI: 0.41 40S ribosomal protein S27-like protein OS=Homo sapiens GN=RPS27L PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15135 485.2174 968.4202 968.4386 -0.0183 0 31 0.035 1 R.LTEGCSFR.R 15134

Proteins matching the same set of peptides: P42677|RS27_HUMAN Mass: 9797 Score: 31 Queries matched: 2 40S ribosomal protein S27 OS=Homo sapiens GN=RPS27 PE=1 SV=3

401. Q6ZR08|DYH12_HUMAN Mass: 359792 Score: 31 Queries matched: 31 emPAI: 0.01 Dynein heavy chain 12, axonemal OS=Homo sapiens GN=DNAH12 PE=2 SV=2

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Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5094 503.0922 502.0849 502.2751 -0.1902 0 6 16 1 R.GAVEK.W 9163 421.7559 841.4973 841.4698 0.0275 0 3 24 4 K.VPEIWAK.R 1235 9209 12018 442.7366 883.4585 883.4585 0.0000 0 8 7.4 9 K.LMNHLEK.D 13061 453.3037 904.5928 904.4477 0.1452 0 2 40 1 K.GVFGPPM GK.K 15085 483.7530 965.4914 965.4562 0.0352 0 4 19 5 R.DVVM DMIK.M 15420 489.7847 977.5549 977.4851 0.0698 1 2 32 8 K.KENELMAK.R 16870 517.2142 1032.4138 1032.5426 -0.1288 1 2 40 4 K.GVFGPPM GKK.C 19201 552.2521 1102.4896 1102.6135 -0.1239 0 4 26 1 K.SFIAVPVTNR.I 19501 555.7344 1109.4543 1109.4488 0.0055 0 31 0.032 1 K.WECPFDEK.G 19500 19594 558.2927 1114.5709 1114.6281 -0.0571 1 8 7.7 6 R.VRIINCNVK.Y 20049 566.2554 1130.4962 1130.5390 -0.0428 0 9 6.9 7 K.MTNEPPTGLR.L 20034 20038 20050 20051 20056 21400 597.2849 1192.5553 1192.6425 -0.0871 1 5 15 3 K.AAVHRNLEGAR.K 23449 636.3547 1270.6948 1270.6452 0.0496 1 0 44 6 R.DAVANKHTMIR.L 24592 663.8401 1325.6657 1325.7191 -0.0534 0 10 5.1 3 K.QSVENLLPTPTK.S 24595 24596 24597 24901 671.3291 1340.6437 1340.7663 -0.1226 1 5 17 1 K.AAIAAEKEALNLK.L 24895 26007 708.3540 1414.6935 1414.7642 -0.0707 0 13 2.2 3 K.WLIQVEDLMLR.S 26151 715.8541 1429.6935 1429.6837 0.0098 1 14 1.9 3 R.EIYDSKEPHNAK.F 28378 516.5213 2062.0560 2061.9969 0.0591 0 1 24 2 R.FFFLSNDEMLEILSETK.D 30296 430.8812 2579.2434 2579.3280 -0.0846 0 1 18 1 K.FLSLASEIM LLPQWIHYTMVR.L

402. P01903|2DRA_HUMAN Mass: 28760 Score: 31 Queries matched: 4 emPAI: 0.13 HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens GN=HLA-DRA PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7442 408.7093 815.4040 815.3926 0.0114 0 30 0.077 1 R.EDHLFR.K 7441 18384 538.2593 1074.5040 1074.5855 -0.0815 1 (1) 50 6 K.ANLEIMTKR.S 18888 546.2125 1090.4104 1090.5804 -0.1701 1 9 5.7 2 K.ANLEIM TKR.S

403. P51553|IDH3G_HUMAN Mass: 43166 Score: 31 Queries matched: 54 emPAI: 0.09 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens GN=IDH3G PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11598 436.7635 871.5124 871.4988 0.0136 1 11 5.2 1 K.SRNNILR.T 11689 437.7443 873.4740 873.4920 -0.0179 0 31 0.056 1 K.VATVAGSAAK.A 11674 11675 11684 11686 11687 11688 11690 11691 11 12270 444.7535 887.4924 887.4825 0.0099 1 17 1.4 1 K.LAQESGRK.K 12256 12259 12262 12268 12274 12275 12277 12281 2947

404. P10451|OSTP_HUMAN Mass: 35572 Score: 31 Queries matched: 4 emPAI: 0.11 Osteopontin OS=Homo sapiens GN=SPP1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 3210 449.7627 897.5109 897.4556 0.0553 1 13 2.5 6 K.EEDKHLK.F 5442 519.2422 1036.4698 1036.4309 0.0389 0 6 48 1 K.QADSGSSEEK.Q 5436 25666 694.2955 1386.5765 1386.6263 -0.0498 0 31 0.03 1 R.ISHELDSASSEVN.-

405. Q08752|PPID_HUMAN Mass: 41137 Score: 31 Queries matched: 11 emPAI: 0.09 40 kDa peptidyl-prolyl cis-trans isomerase OS=Homo sapiens GN=PPID PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 2683 439.7154 877.4163 877.5021 -0.0858 1 4 24 3 K.KYAEVLR.Y 11832 13878 464.7111 927.4076 927.4661 -0.0585 0 1 47 9 K.AQGIAPEDK.A 4113 472.2517 942.4889 942.5386 -0.0497 0 4 68 9 R.ILENVEVK.G 14348 17701 529.3150 1056.6155 1056.6430 -0.0275 0 31 0.042 3 K.ILLITEDLK.N 17687 5687 17699 17700 19536 556.7992 1111.5839 1111.6965 -0.1125 1 3 21 5 K.AIQAELLKVK.Q

406. Q14974|IMB1_HUMAN Mass: 98420 Score: 31 Queries matched: 5 emPAI: 0.04 Importin subunit beta-1 OS=Homo sapiens GN=KPNB1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6573 594.1884 593.1811 593.2809 -0.0998 0 9 5.5 1 K.ANFDK.E 6579 12705 451.2454 900.4763 900.4916 -0.0153 0 5 21 9 R.LELEAAQK.F 3303 22387 613.3246 1224.6347 1224.6575 -0.0228 0 31 0.037 1 R.VLANPGNSQVAR.V

407. Q9BTC0|DIDO1_HUMAN Mass: 245434 Score: 31 Queries matched: 24 emPAI: 0.01 Death-inducer obliterator 1 OS=Homo sapiens GN=DIDO1 PE=1 SV=5 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7634 412.2241 822.4336 822.4963 -0.0627 0 31 0.04 3 K.IALHIEK.E 7600 7624 7631 7638 7639 7649 832 415.2234 828.4322 828.4930 -0.0607 1 2 72 6 K.GIQSRLR.K 10263 432.7061 863.3977 863.4534 -0.0557 1 1 54 5 K.AAAMAASKK.T 12058 443.2147 884.4149 884.4352 -0.0202 0 2 31 6 R.APEAAAAER.E 13181 454.2155 906.4164 906.4559 -0.0395 1 9 8.4 7 K.KSFDPSAR.E 14902 479.7699 957.5253 957.5131 0.0122 0 1 46 5 K.VATVPQSEK.K 18429 538.7457 1075.4768 1075.5258 -0.0490 1 6 15 8 K.SSEDQGIKGR.I 19618 559.2587 1116.5028 1116.5829 -0.0801 0 6 13 5 R.GPPPGHFVGPR.G 21851 402.8591 1205.5555 1205.5676 -0.0122 0 5 15 2 K.ALGSAQYEDPR.N 21928 604.8036 1207.5926 1207.6271 -0.0344 1 6 13 4 R.SIMFNLKDPK.N 21931 21932 21962 606.2246 1210.4346 1210.6207 -0.1861 1 1 19 1 K.DPKNQGLFHR.V 3083 448.2499 1341.7280 1341.6637 0.0643 1 0 1.8e+002 2 K.ESARDPKPEASR.A 3258 450.2599 1347.7578 1347.6969 0.0609 1 0 2.1e+002 1 K.HAAATMKFLSSGK.E 25168 677.8545 1353.6944 1353.7252 -0.0308 0 2 28 8 K.SILAKPSSSPDPR.Y 25854 466.9349 1397.7829 1397.7878 -0.0049 1 2 25 1 K.VATVPQSEKKPSK.Y 25885 701.3214 1400.6283 1400.6055 0.0227 1 0 41 9 M.DDKGDPSNEEAPK.A

408. Q8N7S2|DNJ5G_HUMAN Score: 31 Queries matched: 5 DnaJ homolog subfamily C member 5G OS=Homo sapiens GN=DNAJC5G PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6440 583.2801 582.2728 582.2874 -0.0146 0 14 1.2 1 K.EAAHR.L 9741 425.7116 849.4086 849.3868 0.0218 0 31 0.05 2 K.GASPEDFK.K 9764 15410 489.7371 977.4597 977.4818 -0.0221 1 2 33 3 K.KGASPEDFK.K 15418 489.7607 977.5068 977.4818 0.0250 1 4 22 6 K.GASPEDFKK.S

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409. P49720|PSB3_HUMAN Mass: 23219 Score: 31 Queries matched: 2 emPAI: 0.16 Proteasome subunit beta type-3 OS=Homo sapiens GN=PSMB3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 12363 446.7533 891.4920 891.5065 -0.0145 0 31 0.051 1 R.LNLYELK.E 15670 495.2609 988.5073 988.4760 0.0314 0 7 13 3 K.NCVAIAADR.R

410. Q9NY33|DPP3_HUMAN Mass: 82880 Score: 31 Queries matched: 10 emPAI: 0.09 Dipeptidyl-peptidase 3 OS=Homo sapiens GN=DPP3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7419 408.2342 814.4538 814.4548 -0.0010 0 19 0.74 1 R.LLSPTER.L 9584 422.7443 843.4740 843.4702 0.0038 0 27 0.13 1 K.VVEQLEK.A 9588 9590 9595 11839 439.7334 877.4522 877.4545 -0.0023 0 19 0.85 1 K.LFVQDEK.G 14323 471.7342 941.4538 941.4566 -0.0029 0 13 2.4 1 R.AQDPDQLR.Q 14798 478.7742 955.5339 955.5451 -0.0112 0 12 3.6 1 R.SVGKPALER.F 16068 502.7693 1003.5240 1003.5338 -0.0099 0 26 0.14 1 R.GDYAPILQK.V 27687 588.2963 1761.8672 1761.9009 -0.0337 0 11 2.6 1 R.VILGSEAAQQHPEEVR.G

411. Q9C099|LRCC1_HUMAN Mass: 120719 Score: 31 Queries matched: 14 emPAI: 0.03 Leucine-rich repeat and coiled-coil domain-containing protein 1 OS=Homo sapiens GN=LRRCC1 PE=2 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7172 403.7332 805.4518 805.4698 -0.0180 0 8 10 6 R.EIYLLR.T 7168 7170 13660 460.7256 919.4367 919.4433 -0.0066 0 6 14 6 K.CIDSANLK.V 13672 13683 461.2212 920.4279 920.4967 -0.0688 1 1 45 8 R.SKIPYDAK.T 13697 461.7046 921.3946 921.4589 -0.0643 1 15 1.5 1 K.TLEKM ER.Q 16070 502.7701 1003.5257 1003.5888 -0.0631 1 31 0.047 1 R.KMKPPYLK.E 16930 517.2728 1032.5311 1032.5274 0.0037 1 8 9.7 6 K.LKDCLQEK.D 16928 5879 540.1505 1078.2865 1078.4753 -0.1889 0 6 10 1 K.LHSMDDAFK.R 5880 5881 21068 588.7800 1175.5455 1175.5968 -0.0513 1 6 13 5 K.QKCIDSANLK.V

412. Q7KZF4|SND1_HUMAN Mass: 102618 Score: 31 Queries matched: 26 emPAI: 0.04 Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens GN=SND1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 6155 558.2998 557.2926 557.2922 0.0004 0 5 46 3 K.TPQGR.E 26 401.2142 800.4138 800.4392 -0.0254 0 11 17 1 R.EVLPSTR.L 1668 430.2140 858.4134 858.4348 -0.0214 0 2 1.2e+002 1 K.VHFTAER.S 12356 446.7226 891.4306 891.4450 -0.0144 0 12 4.5 1 K.YTIENPR.H 16885 517.2517 1032.4889 1032.5088 -0.0198 0 31 0.046 1 R.VADISGDTQK.A 1921 432.8728 1295.5967 1295.6986 -0.1019 1 11 3.8 1 K.FFTESRLLQR.D 1902 1906 1915 1922 1963 1992 2004 2010 2026 20

413. Q9ULM0|PKHH1_HUMAN Mass: 152733 Score: 31 Queries matched: 31 emPAI: 0.02 Pleckstrin homology domain-containing family H member 1 OS=Homo sapiens GN=PLEKHH1 PE=2 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5353 516.2896 515.2823 515.3431 -0.0608 1 6 26 1 K.AIKGK.D 5366 19 400.7769 799.5392 799.5167 0.0224 0 19 0.89 1 R.VLQSLLK.V 11739 437.7547 873.4947 873.4920 0.0028 1 11 6.4 6 K.TVQEKAAK.I 11752 12817 451.7601 901.5056 901.4981 0.0074 1 11 6.3 1 R.KTSGLGSPR.A 12758 12800 12809 12816 12818 3338 12826 12836 12 14061 466.7459 931.4771 931.5087 -0.0316 1 8 11 7 K.SEGGTRVVK.L 14030 3902 14070 15422 489.7891 977.5636 977.5043 0.0594 0 4 23 7 R.HGAPAEQLR.H 15447 490.7415 979.4684 979.5280 -0.0596 1 16 1.4 1 R.KWPFFGAK.L 16332 508.7600 1015.5055 1015.6066 -0.1011 1 13 2.9 3 K.IKEWVTLK.L 16329 16331 16333 16334 16335 16337 20392 571.7851 1141.5556 1141.5979 -0.0423 0 31 0.044 1 R.EGGPGSSLTLPK.V 2842 442.8713 1325.5922 1325.7013 -0.1091 1 3 28 3 K.SGYLLKM GSQVK.T 6680 606.6209 1816.8408 1816.9029 -0.0621 1 3 19 7 -.M AELKVEAPASVDWQK.R

414. P06744|G6PI_HUMAN Mass: 63335 Score: 31 Queries matched: 20 emPAI: 0.12 Glucose-6-phosphate isomerase OS=Homo sapiens GN=GPI PE=1 SV=4 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5733 531.2882 530.2810 530.3176 -0.0367 0 9 29 1 M.AALTR.D 1401 423.2060 844.3975 844.3926 0.0049 0 36 0.061 1 K.SPEDLER.L 9601 9602 9603 9606 9607 9610 9611 9613 9614 9615 96 9837 426.7151 851.4157 851.4137 0.0020 0 23 0.28 1 K.INYTEGR.A 9836 15416 489.7567 977.4988 977.4930 0.0057 1 27 0.1 1 R.LFDANKDR.F 17182 522.2812 1042.5478 1042.5659 -0.0180 0 19 0.68 1 R.SNTPILVDGK.D 22225 609.8169 1217.6193 1217.6404 -0.0211 0 28 0.091 1 K.HFVALSTNTTK.V

415. P27482|CALL3_HUMAN Mass: 16937 Score: 31 Queries matched: 2 emPAI: 0.51 Calmodulin-like protein 3 OS=Homo sapiens GN=CALML3 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7556 411.2019 820.3892 820.4113 -0.0221 0 18 0.95 1 R.ELGTVM R.S 24410 657.8215 1313.6284 1313.6575 -0.0291 0 32 0.031 1 R.SLGQNPTEAELR.D

416. Q01813|K6PP_HUMAN Mass: 86454 Score: 31 Queries matched: 6 emPAI: 0.04 6-phosphofructokinase type C OS=Homo sapiens GN=PFKP PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7745 412.7224 823.4302 823.4301 0.0002 0 31 0.04 1 R.VGIADGHR.M 7763 7845 413.2112 824.4079 824.2970 0.1108 0 2 28 2 -.M DADDSR.A 13181 454.2155 906.4164 906.4196 -0.0032 0 21 0.52 1 R.GGTPSAFDR.I 21871 402.8898 1205.6475 1205.6478 -0.0003 1 1 37 7 R.AM EWITAKLK.E 25067 450.9053 1349.6939 1349.7918 -0.0979 1 1 42 5 R.LAIKLPDDQIPK.T

417. P55060|XPO2_HUMAN Mass: 111145 Score: 31 Queries matched: 14 emPAI: 0.03 Exportin-2 OS=Homo sapiens GN=CSE1L PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 5102 503.2411 502.2338 502.2751 -0.0413 0 11 15 1 K.ADGIK.Y

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7125 402.7156 803.4166 803.3960 0.0206 0 2 53 9 R.AACDLVR.G 14733 477.2946 952.5746 952.5957 -0.0210 0 31 0.042 2 K.IIIPEIQK.V 4393 14734 14735 4394 4395 15849 499.2455 996.4765 996.5240 -0.0475 0 2 30 9 K.TLDPDPAIR.R 4983 19938 563.2779 1124.5413 1124.6190 -0.0777 1 7 9.5 4 K.KTLDPDPAIR.R 19943 27914 477.0219 1904.0587 1904.0515 0.0072 1 8 4.5 1 K.MFGMVLEKIIIPEIQK.V 27913

418. Q5H9F3|BCORL_HUMAN Mass: 184237 Score: 31 Queries matched: 54 emPAI: 0.02 BCoR-like protein 1 OS=Homo sapiens GN=BCORL1 PE=1 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7999 415.2200 828.4254 828.4705 -0.0451 0 8 12 10 K.LAGDTKPK.N 13029 453.2693 904.5240 904.4654 0.0586 0 3 31 1 R.YEPDLLR.L 17778 530.7637 1059.5129 1059.5019 0.0110 0 16 1.7 2 K.QVDCSPAGVK.A 17761 17767 17769 17771 17772 17776 17777 17779 18478 539.2712 1076.5279 1076.6091 -0.0812 1 10 5.6 3 K.LSSRIFQAR.F 18466 18469 18472 18473 18474 18482 18483 18486 1 19012 547.2849 1092.5552 1092.6403 -0.0852 1 3 26 6 R.QKLPLPNQR.K 20049 566.2554 1130.4962 1130.5316 -0.0354 0 31 0.047 2 K.TSSSQSLEHR.L 20034 20035 20036 20037 20038 20040 20042 20043 23623 642.3409 1282.6672 1282.6881 -0.0209 0 1 39 6 R.KPTKPESQSPGK.R 24367 437.8902 1310.6487 1310.7016 -0.0529 0 1 34 2 R.CLPGVLASPELR.S 25204 679.3312 1356.6479 1356.6269 0.0210 1 14 2.1 3 K.RADSHEEGSLEK.K 25203 25206 25207 25208

419. Q92882|OSTF1_HUMAN Mass: 23943 Score: 31 Queries matched: 3 emPAI: 0.16 Osteoclast-stimulating factor 1 OS=Homo sapiens GN=OSTF1 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 7072 401.2408 800.4670 800.4392 0.0278 0 11 5.2 2 R.VGVNGLDK.A 9620 423.2364 844.4583 844.4555 0.0028 0 13 3.9 1 R.GNLSWLR.E 4976 498.7524 995.4902 995.5076 -0.0174 0 31 0.043 1 R.ALYTFEPR.T

420. P07858|CATB_HUMAN Mass: 38766 Score: 31 Queries matched: 6 emPAI: 0.10 Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11794 438.7342 875.4539 875.4501 0.0038 0 32 0.048 1 K.LPASFDAR.E 11791 11795 15866 499.7402 997.4659 997.4790 -0.0131 0 2 34 6 K.DIMAEIYK.N 15867 499.7427 997.4708 997.4790 -0.0082 0 4 18 2 R.VMFTEDLK.L 24404 657.7734 1313.5322 1313.5962 -0.0640 0 1 30 9 K.ICEPGYSPTYK.Q

421. P02788|TRFL_HUMAN Mass: 80014 Score: 30 Queries matched: 8 emPAI: 0.05 Lactotransferrin OS=Homo sapiens GN=LTF PE=1 SV=6 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 1528 426.7153 851.4161 851.4137 0.0024 0 5 17 6 K.DSAIGFSR.V 16492 510.7568 1019.4990 1019.5036 -0.0046 0 30 0.055 1 R.DGAGDVAFIR.E 16487 25771 465.2398 1392.6976 1392.6707 0.0269 0 5 16 3 R.CLAENAGDVAFVK.D 25767 25793 27392 555.9303 1664.7692 1664.7875 -0.0183 0 2 25 3 R.SCHLAMAPNHAVVSR.M 28245 412.0225 2055.0762 2054.9448 0.1313 1 1 21 1 R.SCHLAM APNHAVVSRMDK.V

422. O60296|TRAK2_HUMAN Mass: 102268 Score: 30 Queries matched: 21 emPAI: 0.04 Trafficking kinesin-binding protein 2 OS=Homo sapiens GN=TRAK2 PE=1 SV=2 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 15824 498.2551 994.4956 994.5811 -0.0855 1 30 0.047 2 K.LKEHVIEK.E 15815 15816 15818 15819 15820 15821 15822 15823 15 18858 545.3157 1088.6168 1088.5826 0.0342 0 7 10 1 R.LSIGESITNR.R 5980 19567 557.7852 1113.5557 1113.6506 -0.0948 1 3 28 7 K.LLQERGISAK.V

423. Q8NCA9|ZN784_HUMAN Mass: 35071 Score: 30 Queries matched: 19 emPAI: 0.11 Zinc finger protein 784 OS=Homo sapiens GN=ZNF784 PE=2 SV=1 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 13792 463.2063 924.3980 924.4640 -0.0659 0 5 13 5 R.FCAKPFR.R 19154 550.2855 1098.5565 1098.6913 -0.1348 1 3 26 1 R.AFKALAPLLR.H 20073 566.7574 1131.5002 1131.4727 0.0275 1 5 16 4 R.SSDMRDHER.V 20065 20066 20068 20071 20072 20074 20087 20091 2 20523 574.7661 1147.5177 1147.4676 0.0500 1 (3) 27 1 R.SSDM RDHER.V 21792 602.3243 1202.6340 1202.5826 0.0515 0 30 0.051 2 -.MAAARPEAQSR.S 21776 21789 21790 21791 21794

424. Q92889|XPF_HUMAN Mass: 105333 Score: 30 Queries matched: 5 emPAI: 0.04 DNA repair endonuclease XPF OS=Homo sapiens GN=ERCC4 PE=1 SV=3 Query Observed Mr(expt) Mr(calc) Delta Miss Score Expect Rank Peptide 11879 440.6947 879.3748 879.4338 -0.0590 1 30 0.056 1 K.EKEAFEK.L 11880 5387 517.2607 1032.5067 1032.4910 0.0158 0 3 1.4e+002 8 K.ASMVVPEER.E 21966 606.3013 1210.5881 1210.5805 0.0077 1 11 3.7 3 K.AEEVWMKFR.K 21968

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