Vaccines Check with Your Beyond Get The Importance Veterinarian Vaccinating Vaccinating of It is imperative for and dairy Vaccination Side Effects Right can threaten even the best beef producers to work closely with Modern vaccines have proven to be both effective and safe. and dairy operations. The right vaccination However, occasionally an animal will experience mild side effects. their herd veterinarian to both Reactions noted may include low , soreness and/or swelling program will control and/or prevent many of develop the initial vaccination at injection site, or unusual lethargy. These should disappear in a these diseases, and is vital to achieve optimal few hours or a day or two. program and make alterations as reproductive and growth rates in cattle, Rarely, more serious reactions may occur. If the animal appears needs and circumstances change. unusually weak, develops severe diarrhea, has difficulty breathing, as well as to maintain overall herd health. and/or there is extreme swelling at the injection site, a veterinarian In addition, a veterinarian can provide valuable should be called immediately. insight and advice concerning other aspects of When vaccinations are incorporated as part herd management by carefully observing the Other Health Considerations of a management plan that includes good animals at regular intervals and conferring with the producer. A good partnership with a bovine Keep in mind that food and food-producing animals are strongly nutrition, effective sanitation, the appropriate veterinarian can pay big dividends over the influenced by what they eat. Good nutrition is a top priority, long-term. as is plenty of clean water, comfortable living conditions, and environment and other practices, the appropriate veterinary care. Regular deworming and other results include a better quality product responsible management practices are vital to operating a successful cattle business. and higher profits.

Cattle should be checked at least once each day in confinement The Right Vaccination Program operations and as often as possible in pasture environments. Individuals should appear bright and healthy, move soundly, Although no is 100 percent effective all the time, most and have no abnormal discharge from the nose, eyes or raise the general herd immunity level, decrease severity of clinical mouth. Appetites should be strong, with plenty of good , and minimize the threat of the spread of infectious feedstuffs available. diseases.

Following good, basic cattle management plans—and including Individual herd circumstances may affect vaccination program the right vaccination program—will help ensure a healthy herd choices. Those that might need to be considered include: and many years of profitability. • Regional variations • Age For More Information • Disease history • Timing • Housing • Cost vs. benefits For more information about beef and dairy cattle diseases, • Feeding practices • Breeding/Pregnancy Status or vaccinations, please visit: www.the-best-defense.com • Management practices • Type of vaccine and more

Types of Vaccines

Bovine vaccines include two main types: modified-live products and killed products. It is important to know the difference, as it affects storage and handling. Vaccine types are usually clearly marked on the label.

Modified-live vaccines are UV light, heat and disinfectant sensitive. Keep them cool and away from sunlight. Follow BQA guidelines for proper needle use and disposal.

Killed vaccines are less sensitive, but should still be kept cool CHECKwith and protected from sunlight. Follow BQA guidelines for proper YOUR VET needle use and disposal. Copyright© 2021 Intervet Inc., a subsidiary of Merck & Co., Inc. All rights reserved BE SURE IT’S RIGHT FOR YOU. Intervet Inc. (d/b/a Merck Animal Health) RET-4576-Cattle Get Vaccinating Right Brochure | US-NAL-210100011 Histophilus somni (Haemophilus somnus) – Know the Diseases Haemophilus somnus (Histophilus somni) Bacterium can Know the Antigens Know the Vaccines cause pneumonia, neurological disease, and abortions. Can be primary cause of pneumonia or a secondary Viral Vaccines IBR, BVD Type 2, and BRSV, Viral and The most common diseases affecting cattle fall into Cattle 5-way viral + VISTA® ONCE SQ bacterial invader. Mannheimia and BVD Type 1, Parainfluenza-3, Bacterial two main categories viral and bacterial. For many Mannheimia haemolytica, and 50 Dose and 10 Dose diseases treatment is not an option and the best Leptospirosis – This bacterium causes milk drop, Pasteurella combo Pasteurella multocida

defense against them are vaccines. An effective abortions, and infertility in breeding cattle. May also Viral Vaccines** 3 Intranasal Pasteurella Pasteurella multocida and ONCE® PMH IN IBR 1 BVD Type 2 BVD Type PI BRSV Mannheimia Haemolytica Pasteurella multocida Leptospirosis Vibriosis Mannheimia haemolytica vaccination program gives you the power to get in cause urinary disease and anemia in all cattle groups. and Mannheimia vaccine 50 Dose and 10 dose front of disease before it strikes, tackling it before Five different types of “lepto” can cause disease. VISTA® ONCE SQ it gains ground. Instead of treating disease, you can Most vaccines contain all five. IBR, BVD Type 2 and BRSV, ® Cattle 5-way Viral BVD Type 1 and Parainfluenza-3 VISTA 5 SQ keep producing healthy, profitable cattle. ONCE® PMH IN 50 Dose and 10 dose Pasteurella (Pasteurella multocida and Mannheimia ) – A group of commonly found ® haemolytica VISTA 5 SQ Cattle 5-way Viral IBR, BVD Type 2, BRSV, and ® Leptospirosis, BVD Type 1 and VISTA 5 VL5 SQ Viral BRSV – Bovine Respiratory Syncytial Virus in the environment and animal itself that compound Lepto + Vibrio Parainfluenza-3,L. hardjo organism, 50 Dose and 10 Dose Diseases Causes pneumonia and nasal discharge. respiratory diseases caused by viruses or other VISTA® 5 VL5 SQ and Campylobacter fetus bacteria. Keeping animals healthy overall is the Bacterial pneumonia often develops secondarily. Intranasal Cattle Infectious Bovine Rhinotracheitis BOVILIS® NASALGEN® 3 BOVILIS® NASALGEN® 3 (IBR) virus, Bovine Respiratory Primarily affects cattle less than 2 years old. best protection. Use of a broad spectrum vaccine can 3-way viral vaccine Syncytial Virus (BRSV) and 50 Dose , 10 Dose and Single dose prevent lung damage caused by Pasteurella Parainfluenza-3 virus BVD – Bovine Viral Diarrhea BOVILIS® NASALGEN® 3-PMH and Mannheimia. Intranasal Cattle 3-way Infectious Bovine Rhinotracheitis BOVILIS® NASALGEN® 3-PMH Types 1 & 2 – As the most costly viral disease (IBR) virus, Bovine Respiratory viral + Mannheimia and 50 Dose , 10 Dose and Single dose ® ® Syncytial Virus (BRSV) and in cattle, BVD causes digestive tract erosions, Pinkeye (caused by Moraxella bovis and Moraxella BOVILIS VISTA BVD CFP Pasteurella combo Parainfluenza-3 virus,Pasteurella abortions, infertility, birth defects and respiratory bovoculi) – Bacterium causes corneal ulcers with multocida and Mannheimia haemolytica disease. Immune system suppression leaves animals temporary blindness and/or permanent damage to Cattle BVD type 1 Bovine Viral Diarrhea (BVD) BOVILIS® VISTA® BVD CFP

Types 1 & 2. open to other . A fetus infected in utero the eye’s cornea. It is spread by flies feeding on the and 2 viral vaccine 50 Dose and 10 Dose

prior to 120-140 days gestation may become a infected eye drainage. persistently infected (PI) calf and shed the virus to Clostridial Vaccines Vibriosis – This bacterium is a venereal disease spread Blackleg Malignant Edema Sordellii Black Disease Enterotoxemia Redwater Tetanus Somni Clostridial Vaccines other animals for life. Those infected after 140 days Blackleg, Malignant Edema, by bulls during natural service. Vibrio can ® Cattle 7-way VISION® 7 gestation may have impaired immune function and be VISION 7* * Sordellii, Black Disease, cause early embryonic death and repeat breeders. Blackleg (+ Somni*) and Enterotoxemia 250 Dose, 50 Dose and 10 Dose and (Histophilus Somni*) more prone to serious infections within the first year ® VISION 8* ® of life. Testing for BVD-PI calves and removing them * *(with optional Somni in VISION 7 SOMNUS) from the group as soon as possible is beneficial. Clostridial diseases are caused by bacteria. These CAVALRY® 9 Cattle 8-way Blackleg, Malignant Edema, VISION® 8 Clostridial Blackleg (+ ) Sordellii, Black Disease, diseases generally are divided into three groups: Somni* Enterotoxemia, Red Water and 50 Dose and 10 Dose IBR – Infectious Bovine Rhinotracheitis (Rednose) Diseases COVEXIN® 8 (Histophilus Somni*) Virus causes upper respiratory disease, eye lesions, hepatic group, intestinal group, and muscle group. *(with optional Somni in VISION® 8 SOMNUS) Most commercial vaccines contain protection against VISION® CD-T Cattle 8-way Blackleg, Malignant Edema, Sordellii, CAVALRY® 9 abortions and infertility. IBR is extremely contagious Black Disease, Enterotoxemia, and outbreaks can be severe. seven of the most common disease-causing clostridial Blackleg + Tetanus Red Water and Tetanus 125 Dose, 50 Dose and 10 Dose organisms. VISION® CD

– Virus causes mild ® PI3 Parainfluenza Type 3 Cattle and 8-way Blackleg, Malignant Edema, COVEXIN 8 Hepatic Group – Cl. novyi (Black Disease), ® ® Black Disease, Enterotoxemia, respiratory disease that may lead to other *(with optional Somni available in VISION 7 SOMNUS or VISION 8 SOMNUS) Blackleg + Tetanus Red Water and Tetanus 50 Dose and 10 Dose respiratory infections, both viral and bacterial. and Cl. haemolyticum (Redwater)

Black Disease causes liver necrosis and blood vessel Enterotoxemia and Tetanus ® Rotavirus and Coronavirus Multi Species CD-T VISION C D -T – Leading viral causes of damage, and produces a that causes rapid death. 50 Dose calf scours (diarrhea) in young calves. May weaken Redwater causes death in the liver, red-colored Pinkeye Vaccines the individual and slow growth, and may cause death urine, and death. Moraxella bovis Moraxella bovoculi Blackleg Malignant Edema Sordellii Disease Black Enterotoxemia Pinkeye Vaccines in highly-compromised individuals. As many other ® Intestinal Group – Cl. perfringens Types C & D 20/20 VISION 7 scour causing pathogens can also be lethal to the calf Cattle 7-way Blackleg, Malignant Edema, 20/20 VISION® 7 (2 mL) PILIGUARD® Pinkeye-1 Sordellii, Black Disease, and are difficult to treat, a broad spectrum vaccine (Enterotoxemia) Sometimes called “purple gut” because Blackleg + Pinkeye Enterotoxemia, and Pinkeye 50 Dose and 10 Dose administered to the cow at the proper time is the best of lesions found during necropsy, this produces TRIVALENT caused by Moraxella bovis that cause illness and death with little or no outward ® defense. Passive immunity is transferred to the calf PILIGUARD Pinkeye+7 Cattle Pinkeye Pinkeye caused by Moraxella bovis PILIGUARD® Pinkeye-1 TRIVALENT from the cow with first milk (colostrum). clinical signs. 50 Dose and 10 Dose MORAXELLA BOVOCULI Muscle Group – Cl. chauvoei (Blackleg), Cl. septicum Cattle 7-way Pinkeye caused by Moraxella bovis, PILIGUARD® Pinkeye + 7 (5 mL) (Malignant Edema), and Cl. sordellii (Sord) chauvoei, C. septicum, Bacterial Brucellosis – A reproductive system bacterial disease Blackleg + Pinkeye C. novyi Type B, C. sordellii and C. 50 Dose and 10 Dose These organisms produce toxins that cause perfringens Types C and D. Diseases nearly eradicated in the United States. May cause late- muscle and/or heart lesions leading to death. term abortions, weak calves or retained afterbirth. Moraxella Bovoculi Pinkeye caused by Moraxella bovoculi. Moraxella Bovoculi May be spread to other species, including humans— 50 Dose and 10 Dose Scours

although with different symptoms. Rotavirus E. coli K99 Enterotoxemia Coronavirus *GUARDIAN is the only scours Scours GUARDIAN® vaccine on the market with two inactivated coronaviruses Calf Scours Rotavirus, E. coli K99, GUARDIAN® Pre-calving vaccination option Enterotoxemia, Coronavirus BOVILIS® CORONAVIRUS 50 Dose and 10 Dose

® **Modified Live Vaccines:All VISTA vaccines are labeled as being safe for use in pregnant heifers and cows or calves BOVILIS Coronavirus Coronavirus BOVILIS® CORONAVIRUS nursing pregnant cows provided the cows and heifers in the herd are vaccinated prior to breeding, within the previous Intranasal 50 Dose and 10 Dose 12 months, with any of the modified live IBR and BVD containing vaccine(s) in this product line. Read product label Post-calving vaccination option carefully. If cows have not previously been vaccinated with modified-live vaccines consult your veterinarian before use.