Anti-RIT1 Monoclonal Antibody, Clone 25H8 (DCABH-4956) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-RIT1 monoclonal antibody, clone 25H8 (DCABH-4956) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse monoclonal to RIT1

Antigen Description Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.

Specificity Antibody detects recombinant Rit1 protein expressed in 293 cells, but does not cross-react with Rin protein.

Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant full length human Rit protein and mouse myeloma cells.

Isotype IgG1

Source/Host Mouse

Species Reactivity Mouse, Human

Clone 25H8

Purity IgG fraction

Conjugate Unconjugated

Applications WB

Positive Control 293 cells expressing HA-tagged Rit1 protein.

Format Liquid

Size 100 μg

Buffer Preservative: 3mM Sodium Azide; Constituents: 50% Glycerol, 20mM Sodium phosphate, 150mM Sodium chloride, pH 7.5

Preservative 3mM Sodium Azide

Storage store at -20°C. Avoid freeze / thaw cycles.

Ship Shipped at 4°C.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name RIT1 Ras-like without CAAX 1 [ Homo sapiens ]

Official Symbol RIT1

Synonyms RIT1; Ras-like without CAAX 1; Ric (Drosophila) like, expressed in many tissues , RIT; GTP- binding protein Rit1; GTP binding protein Roc1; MGC125864; MGC125865; RIBB; Ric like; expressed in many tissues; ROC1; GTP-binding protein Roc1; ras-like without CA

Entrez Gene ID 6016

Protein Refseq NP_001243749

UniProt ID Q92963

Chromosome Location 1q21.2

Pathway NGF signalling via TRKA from the plasma membrane, organism-specific biosystem; Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signalling by NGF, organism-specific biosystem; Signalling to ERKs, organism-specific biosystem; Signalling to p38 via RIT and RIN, organism- specific biosystem; Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem;

Function GTP binding; GTPase activity; calmodulin binding; nucleotide binding; protein binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]