Monoclonal Antibody to Catenin Delta-2 - Supernatant
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OriGene Technologies, Inc. OriGene Technologies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected] BM5099 Monoclonal Antibody to Catenin delta-2 - Supernatant Alternate names: ARM-repeat protein, CTNND2, Delta-catenin, GT24, NPRAP, Neural plakophilin-related, Neurojungin Quantity: 5 ml Background: Delta-Catenin, is a member of the p120 catenin subfamily of catenins. Delta- Catenin/NPRAP was identified as a protein homologous to plakophilin 1 and as a protein interacting with the loop region of presenilin 1 (PS1), the gene most commonly mutated in Alzheimer's disease. Delta-Catenin/NPRAP is almost exclusively expressed in the central nervous system mainly during early brain development. Delta-Catenin/NPRAP has been shown to co- localize and interact with N-cadherin in the mouse brain and to undergo dynamic relocalization during brain development. Uniprot ID: Q9UQB3 NCBI: NP_001323.1 GeneID: 1501 Host / Isotype: Mouse / IgG1 Clone: J19 Immunogen: Synthetic peptide J6 (corresponding to aa 292-309), coupled to KLH Format: State: Liquid Culture Supernatant Applications: Immunoblotting. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: Ready-to-use (only after microwave treatment). Positive Control: Murine Brain, Retina. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: This Monoclonal antibody reacts specifically with Neurojungin (delta-catenin,a unique 160 kD polypeptide of the plakoglobin / armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. Deltacatenin also binds to Presenilin-1, mutations of this protein are described to play a role in familial Alzheimer’s disease. No cross-reaction with other members of the Armadillo / Plakoglobin protein family. The antibody is positive with a 300 kD polypetide in Endothelia from blood vessels. Species Reactivity: Tested: Human, Bovine, Rat, Mouse, Zebrafish. Storage: Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch. General Readings: 1. Paffenholz R, Kuhn C, Grund C, Stehr S, Franke WW. The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction. Exp Cell Res. 1999 Aug 1;250(2):452-64. PubMed PMID: 10413599. For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130513 1 / 2 BM5099: Monoclonal Antibody to Catenin delta-2 - Supernatant 2. Hatzfeld M. The p120 family of cell adhesion molecules. Eur J Cell Biol. 2005 Mar;84(2-3):205-14. PubMed PMID: 15819401. 3. Kosik KS, Donahue CP, Israely I, Liu X, Ochiishi T. Delta-catenin at the synaptic- adherens junction. Trends Cell Biol. 2005 Mar;15(3):172-8. PubMed PMID: 15752981. For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130513 2 / 2 Powered by TCPDF (www.tcpdf.org).