Transition(s) [ Chapter 1 ] November 2020 The aim of this “Transition(s)” magazine, the first chapter of which we present here, is to put into perspective the emblematic actions of the Nord-Europe Excellence Initiative, which, through the integration of Research, Academic Programmes, Interna- tional Projects and Valorisation, justify the construction of a future Experimental Public Establishment (EPE). Its structure, bringing together the current Université de Lille and four schools (Centrale Lille Institut, Lille, ENSAPL and ESJ), in partnership with the CNRS and Inserm, the Inria Lille Nord-Europe centre, the Lille University Hospital and the Institut Pasteur de Lille, will enable the Lille site to position itself as a spearhead on the theme of global transition.

This work has been carried out with the financial support of the French government within the framework of the Pro- gramme d’Investissements d’Avenir (Future Investments’ Programme) (I-SITE ULNE / ANR-16-IDEX-0004 ULNE) managed by the French National Research Agency (ANR). Photo credits: Antoine Repessé, Atmosphere photo, Éléonore Durand, Bilge Sayim, Mésocentre de Lille, Université de Lille, CHU de Lille, Institut Pasteur de Lille, Inria / G. Scagnelli, Her Majesty Queen Elizabeth II 2019, istockphotos2020 Design and production: Caillé associés SOMMAIRE 04 06 08 Editorial Dynamics of An initiative of the Excellence excellence that Initiative contributes to the development of its territory...

10 12 14 Projects Understanding Towards a oriented global changes world of digital towards and providing technology at precision solutions the service of healthcare society

16 18 Changing A consortium, cultures, incubator of the societies and “Université de practices Lille - 2022”

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Editorial

Putting into perspective the emblematic actions of the Lille Nord-Europe Excellence Initiative

ur societies are facing a This justifies the fact that the Lille turning point on a techno- Nord-Europe Initiative of Excellence, logical, economic, health, the I-SITE label awarded to the Lille social and environmen- site in February 2017, has chosen to Otal level. These issues are particularly promote “A university for global tran- significant in our Region, an area of sition”. The project takes an integrated economic, social and ecological tran- approach to all the dimensions of this sition on a par with its important complex issue, with the aim of beco- industrial and mining past. The Rev3 ming one of the European universities project, supported by all the institutio- of excellence in 2030, while at the nal, academic and economic players same time building an identity linked Régis Bordet of the Region, is the striking symbol to its history and territory. The EPE MANAGING DIRECTOR OF THE of this. All these upheavals question (Etablissement Public Expérimental I-SITE ULNE FOUNDATION not only our knowledge and its prac- “Université de Lille”), which is due to tical applications, but also our ability to come into being on 1 January 2022, transmit them, by highlighting their therefore intends to be fully involved complexity. in this turning point, by putting its pro- found organisational transformation On the basis of this regional diagnosis, at the service of a better understan- the public players in charge of higher ding of the global nature of this phase education and research in the metro- of systemic transition initiated at the politan area have their full part to play European level, which is being acce- in responding to these challenges, lerated in the context of the health whether through the penetration of crisis we are currently experiencing. new understanding in the sphere of This ambition should lead to the gene- education, participation in the public ration of courses of action to reinvent debate and the clarification of public progress, using the metropolitan and policies, or by contributing to the life regional ecosystem as a laboratory for of the city, whether institutional or not, observation and experimentation. by developing socio-economic outlets for the products of their research or by Based on its sixty or so research units setting up concrete demonstrators of and their very favourable appraisal, innovative organisations, including on the Lille Nord-Europe Excellence Ini- its campuses. tiative has increased the density of its

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“The attractiveness of our metro- - The development of thematic over the period 2020-2021. It will host polis and the competitiveness of its graduate programmes linked to experts in different specialisations to economy are based on a top level the four hubs, the specification shed light on the debates surroun- of which is to offer a high level of ding transitions in its multiple facets, university, a vector of technological training based on the highlights of be they ecological, economic, tech- and social innovation, an inspiration our research. The development of nological, societal or other. to guide our public policies and a academic programmes is accom- stimulus for its inhabitants.” panied by a transformation of teaching practices through the Damien Castelain, creation of the Lille Learning Lab, a support for innovative teaching president of the MEL projects and the availability of new teaching infrastructures in collabo- ration with foreign universities.

Thanks to its research and training activities, the EPE “Université de Lille” has to integrate scientifically, economically, socially, culturally and architecturally into the city, beco- ming its driving force. It is, in fact, “It is logical and relevant that the hi- the EPE that trains the future pro- fessional and managerial staff, that gher education and research strategy scientific fabric by supporting the is at the source of innovations gene- of our region, embodied in particular consolidation of four themes of rating economic activity and that by the Lille initiative of excellence excellence called “hubs”: Preci- enlightens citizens with reliable data focusing on transitions, is part of the sion healthcare; Changing planet; in order to avoid the excesses linked same dynamic force as our project to ignorance, or even lies. This invol- Human-friendly digital world; Chan- for a third industrial revolution in the ging cultures, societies and practices, ves the co-construction of public Hauts-de-.” directly aligned to the theme of policies with decision-makers from global transition. The hubs serve to local authorities, based on scientific differentiate the Lille site and pro- work generated within the university, Philippe Vasseur, mote interdisciplinarity and the link as is already the case with the Métro- chairman of the Rev3 mission between research and training. They pole Européenne de Lille (MEL) and are based on a dozen or so research the Hauts-de-France Region. But the clusters. Forming partnerships with Lille site will only be able to achieve companies and the socio-profes- its level of ambition by developing sional world and grounding itself its international hold, strengthening in international networks are also its cross-border network with the KU among the priorities of the Lille ini- Leuven, and the universities of Ghent tiative. and Kent in particular, as well as by developing premium partnerships This densification of the scientific with prestigious universities, via fabric is worked in with a complete international chairs and international reform of graduate programmes associate laboratories. undertaken along two main lines: - The evolution of doctoral schools In order to illustrate the challenges towards graduate schools for bet- that the Lille Excellence Initiative ter movement between master wishes to take up in order to respond and doctorate, and a greater ope- to the various transitions that impact ning towards the international and its region, a series of conferences for socio-professional world. the general public is being organised

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DYNAMICS OF THE INITIATIVE OF EXCELLENCE

GLOBAL TRANSITION

4 THEMES OF EXC ELLENCE

PRECISION HEALTHCARE CHANGING PLANET

• promoting systems biology • understanding and monitoring global and precision medicine; changes; • catalysing the digital revolution • seeking alternative solutions to the in biomedical research; exploitation of fossil resources; • optimising the impact for the patient • assessing the impact of global and society. changes on Man, Earth and Societies.

4 GRADUATED PROGRAMMES

“PRECISION HEALTHCARE” “SCIENCE FOR A CHANGING PLANET”

12 RESEARCH CLUSTERS

PHENOTYPES MIXING INNOVATIVE MODELLING STRUCTURED STUDY OF SENSITIVE OF RADIONUCLIDE AND UNSTRUCTURED DATA MATERIALS AEROSOLS OVERSEE

PHENOMIX TEM-ASTER OVERSEE

CATALYTIC RESOURCES MOLECULAR DESIGN HEALTH & ENVIRONMENT AND THE BIO-ECONOMY FOR HEALTH RECABIO

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DYNAMICS OF THE INITIATIVE OF EXCELLENCE

GLOBAL TRANSITION

4 THEMES OF EXC ELLENCE

HUMAN-FRIENDLY CHANGING CULTURES, DIGITAL WORLD SOCIETIES AND PRACTICES

• designing a digital world involving • analysing the organisational and institutional issues human and social sciences; related to the historical transformation of cultures • creating innovative concepts to tame and societies; complexity; • understanding the logics of inequality and forms • developing disruptive technologies of vulnerability in order to build a more inclusive for a society in transition. world; • seeing Europe as a laboratory for transitions (social, political, legal, economic, environmental...).

4 GRADUATED PROGRAMMES

“INFORMATION & KNOWLEDGE “CHANGING CULTURES, SOCIETY” SOCIETIES AND PRACTICES”

12 RESEARCH CLUSTERS

DYNAMICS FOR DISRUPTIVE EUROPE: HISTORICAL CHANGING INSTITUTIONS COMMUNICATIONS AND CONSTRUCTIONS AND ORGANISATIONS CONNECTIVITY AND THE DYNAMICS DYDICO OF TRANSITION

DIGITAL SYSTEMS FOR HUMAN ARTIFICIAL INTELLIGENCE KNOWLEDGE AT THE SERVICE OF PEOPLE VULNERABILITIES AND INCLUSION DISYKNOW HUMAIN@LILLE

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Ecosystem

AN INITIATIVE OF EXCELLENCE THAT CONTRIBUTES TO THE DEVELOPMENT OF ITS REGION...

The Lille Nord-Europe Initiative for Excellence is part of the Hauts-de-France Region’s strategy for specialisation in research and innovation, the training of young people in the Region and of those engaged in a professional activity who wish to refresh their knowledge, and the international visibility of the metropolis and the Region.

... with the socio-economic world ingredients”. Still with SATT Nord, the for a region that creates value I-SITE finances early research pro- The I-SITE and its consortium rely jects with a view to transferral to the “KU Leuven and its Kortrijk campus are on an ecosystem made up of seven socio-economic world (28 projects looking forward to a particularly fruitful competitiveness clusters, the CCI since 2018). Within this framework, and mutually enriching collaboration in and HDFID*, to mobilise and raise it has initiated a specific action to awareness among businesses. develop returns on investment in the field of educational technology as a The initiative collaborates with the the human and social sciences. driver of educational innovation. SATT** Nord and the network of In order to develop partnerships Whether it be multi-site teaching, accelerator-incubators (Euratech- between research laboratories and collaborative approach or personalised nologies, Eurasanté, Plaine Images, companies, it co-finances, with the learning, our joint activities will lead Cré’Innov...). Objective: to develop Hauts-de-France Region and the to concrete learning systems that are student entrepreneurship and the Lille European Metropolis, collabo- perfectly integrated into our academic creation of start-ups by researchers rative projects via thesis schemes or in connection with research, par- in companies, industrial chairs and programmes.”. ticularly in these strategic fields: joint laboratories. Since 2018, over “Artificial intelligence and data 40 companies have been involved in Piet Desmet, sciences at the service of people and these projects. vice-rector of KU Leuven, industry”, “Precision healthcare and rector of Kulak medical devices”, “Circular economy ... with academic programmes and the new functions of equip- ment” and “Food and functional that promote pedagogical innovation and lifelong learning With nearly 80,000 students, the Université de Lille and the Grandes COMPANIES IN Ecoles of the I-SITE consortium 40 THE REGION constitute one of the most impor- INVOLVED IN OUR tant university sites in France. As SYSTEMS a vital player in the local labour market, the consortium offers com- prehensive and diversified academic Leuven Louvain learning lab). This programmes. Pedagogical innova- project benefits in particular from MILLION EUROS tion is a priority of I-SITE. Its actions the expertise of colleagues from KU 3 INVESTED IN A LEARNING in this area are part of a wider tra- Leuven, which is a world reference LAB jectory to co-construct the L5 (Lille in this field. A chair dedicated to

NEARLY FUNDED MOBILITY 400 GRANTS

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“The 3i network enables the researchers of the I-SITE consor- ...with the means to strengthen tium to develop their expertise in its international influence and collaboration with our partners in attractiveness the cross-border region in order to Thanks to the geographical location respond to the challenges shared of the Lille site at the heart of Europe, by the regions of Kent, Flanders and the I-SITE project has enabled its Hauts-de-France. Together, we will establishments to strengthen their find solutions to serve the citizens.” Collaborative study room at Lilliad. collaboration with universities of excellence in the cross-border Kathleen O’Connor, “learning analytics” allows a profes- region. A network called 3i (Interre- coordinator for the development sor from KU Leuven to develop the gional Internationalisation Initiative) of international relations project. On the Lille site, the Lille lear- has been set up with the University at the I-SITE ULNE foundation ning lab, with a budget of around two of Ghent, KU Leuven in Belgium million euros, will put forward a set of and the in the innovative measures to encourage United Kingdom. Objective: to bring the establishment of intensified, inte- together the academic world, local ractive and multi-site courses. Already authorities and the private sector to established on the Pont-de-Bois cam- collaborate on challenges common pus, it will soon be deployed on the to the different regions. In addition to other campuses. The foundation also existing double degrees, this encourages the launch of innovative partnership has fostered the emer- and ambitious projects led by teams gence of new joint research projects, of teachers and engineers from the thanks to the funding of mobi- visibility of the consortium. A second university and schools in its consor- lity grants for teacher-researchers, representative office should be ope- tium. In response to the challenge staff and students (340 grants in ning soon in China. posed by the COVID-19 pandemic, 2019-2020) and joint thesis grants the I-SITE will, for the start of the 2020 (45 grants in 2018-2020). To further Finally, the consortium is actively academic year, contribute 650,000 consolidate their cooperation, the working to attract more internatio- euros to the deployment of new tea- Université de Lille and KU Leuven also nal scientific talent (researchers and ching tools, making this constraint an signed a strategic partnership agree- academics) and to improve their opportunity to teach differently. ment in 2019. reception in France. Winner of a European H2020 project, the PEARL In the field of lifelong learning, the Outside Northwestern Europe, the (Programme for EArly-stage Resear- I-SITE supports the experimental Université de Lille has created the chers in Lille) programme will enable project, ‘University of work-linked InclusU consortium with seven Euro- the recruitment of around thirty training’ which aims to amplify the pean universities. This partnership, international doctoral students on relationship between university and focusing on the issue of social inclu- interdisciplinary research themes. business. sion and civic responsibility, has fed into the creation of the I-SITE hub, Further information on the 3i cross-bor- “Changing cultures, societies and der network: www.3iuni.eu; and on the practices”. Beyond Europe, a repre- PEARL programme: www.pearl-phd-lille.eu sentative office has been opened in

Belo Horizonte (Brazil) to increase the *Hauts-de-France Innovation Development **Société d’Accélération du Transfert de Technologies (Technology Transfer Acceleration Company)

“Developing an ecosystem favourable to In synergy with public policies pedagogical innovation is at the heart of The I-SITE works on behalf of its founding members in close consultation our project to create the Lille learning lab, with the Hauts-de-France Region and the MEL who are represented on which is divided into three areas: suppor- the foundation’s board of directors. They participate in the construction of ting teaching teams in the development its strategy. Their departments collaborate with the I-SITE team, commu- of their teaching practices; creating places nicating every month to coordinate their actions and produce significant conducive to pedagogical experimenta- changes. Given the large number of people that the consortium repre- tion; enhancing and recognising teachers’ sents (over 7,000 staff), its research and development activities cover most of the areas of specialisation presented in the intelligent specialisation investment in this field.” matrix and its regional diagram (SRI-SI). For its part, the MEL has played a major role in structuring the site by financing the research clusters in Lynne Franjié, particular, essential tools for focusing research and technological inno- vice-president for academic programmes vation efforts, and the Lille Leuven Louvain learning lab, an emblematic at the Université de Lille pedagogical innovation project built with our partners from KU Leuven.

In the field of health, its considerable support was decisive for the crea- tion of the PreciDIAB National Centre for Precision Medicine for Diabetes headed by Professor Froguel.

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Health

PROJECTS CENTRED ON PRECISION HEALTHCARE

Advances in biology, technology and information technology now make it possible to help develop more precise medical care. The Lille site participates in the deployment of precision medicine in the flagship topics of the health sector.

“The cooperation among our make health data (analysis and hos- institutions in these large-scale pitalisation reports, mail, medical imagery, photos, etc.) readable and projects for the region is a unique structured in a way that is difficult opportunity. It allows us to unite to use on a large scale in its current excellence at the service of state. patient care at Lille University Phenomix cluster Hospital.” Contacts: Vincent Sobanski and Grégoire Ficheur Frédéric Boiron, A graduate programme general director of the University dedicated to precision health Hospital (CHU) of Lille research As part of the development of the Lille site’s academic programmes, a specialised master’s course known as the “Precision Health graduate programme” opened in September 2020. This interdisciplinary and international programme covers very fundamental aspects of preci- sion healthcare, as well as the social Artificial intelligence issues it raises. Diabetes and Precision Medicine at the service of precision Contact: Anne Tailleux The Lille region is a major player in the The Lille Health Data Warehouse fight against diabetes. Spearheaded (EDS) aims to be one of the main Stimulating the discovery of drugs by the European Genomic Institute centres in France for the exploita- to fight infectious diseases for Diabetes (EGID), it has been awar- tion of big health data. The data Thanks to the support of institutions, ded the label of National Centre for submitted will be used for seve- the Lille site has a chemical library Precision Medicine on diabetes and ral purposes such as research, of over 100,000 molecules with obesity through the PreciDIAB pro- improving the quality of care and therapeutic potential. The model- ject. Thanks to a new method for the medico-economic analysis. This tool ling offered by artificial intelligence detection and quantification at high will contribute to the progress in makes it possible to better identify throughput by mass spectrometry medical knowledge, to the improve- target-molecule interactions whilst of hormones involved in diabetes ment of patient inclusion in clinical avoiding animal experimentation. (INS-SPECT project), Jean-Sébas- trials and to the strengthening of Lille’s health researchers are actively tien Annicotte’s team at LABEX medical and strategic management. participating in the race for new EGID hopes to be able to screen This strategic data will also help to medicines, particularly with regard compounds to identify new drug improve the quality of care. to infectious diseases. The joint candidates. Thanks to the MD-PhD scheme SmartLab team, co-financed with START-AIRR INS-SPECT Project, Institut implemented by the I-SITE, Arthur the help of the I-SITE, will promote européen de génomique du diabète (Euro- Lauriot dit Prevost, a paediatric intern, the collaboration between the M2SV pean Diabetes Genomics Institute- EGID) will be able to spend a year concen- Unit and BioVersys for the develop- Contact: Jean-Sébastien Annicotte trating on his research work prior to ment of treatments aimed at raising becoming clinic chief. His project antibiotic resistance. This project aims to use artificial intelligence to has just been selected by the Inno-

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“The Institut Pasteur de Lille, alongside its partners, is proud to contribute to the construction on the Lille site, of a centre of excel- lence in biomedical research on a European scale.”

Xavier Nassif, general director of the Institut Pasteur de Lille

For a precision cancer diagnosis In France, cancer is the leading cause tissues, providing invaluable help of mortality ahead of cardiovascu- when choosing the perimeter for lar pathologies. The main locations excision, as well as in defining the are the lung, stomach, liver, colon cancer type. and breast. The situation is drama- Snoopy Prematuration Project, vative Medicine Initiative (IMI) of the tic in Hauts-de-France: the regional Proteomics, inflammatory response, European Union. This capacity for excess mortality rate for all cancers mass spectrometry laboratory (PRISM) Contact: Isabelle Fournier innovation is now fully mobilised in combined is around 25%, with pre- the search for effective therapeutic mature morbidity 36% higher than approaches to fight COVID-19. the national average. Among the Learning how to announce Joint team of SmartLab, Centre d’infec- many projects funded in this area, more precise diagnoses tion et d’immunité de Lille (Infection and the Snoopy intelligent sniffer project In Lille, the Presage simulation centre Immunity Centre - CIIL) and Medicines is led by Isabelle Fournier. The pro- supports medical students in the and Molecules for Acting on Living Systems Unit (M2SV) ject aims to analyse volatile organic practice of the main medical proce- Contact: Nicolas Willand compounds using mass spectrome- dures. These courses are aimed at try to detect certain cancers. It has paramedical professions and doc- Quickly diagnosing COVID-19 resulted in funding to develop this tors practising in various specialities: for fast treatment technology. The researcher also surgery, gynaecology, obstetrics, CNRS silver medal winner Sabine works with the cancer department anaesthesia, resuscitation, pneumo- Szunerits and her team at the IEMN of Lille University Hospital to guide logy, general medicine, paediatrics, are developing, in conjunction with surgery. Thanks to the real-time ana- cardiology, etc. The announcement David Devos at the University Hospi- lysis of tissue micro-samples using of the diagnosis becomes a challenge tal and with the help of the LICORNE mass spectrometry, the MSGUIDE for health professionals who will be cohort of patients who have had technology helps rapid discrimina- able to train before treating patients the COVID-19 infection, a rapid dia- tion between cancerous and normal face-to-face. gnostic tool using an immunological sensor approach, thanks to nanopar- ticles. The CorDial-S project, initially supported by the I-SITE via the two million euros made available to the Lille task force to fight COVID-19, has just been selected by the European High throughput screening for already bearing fruit with the identifi- Commission as part of the H2020 call COVID-19 cation of a molecule which will enter for projects, the only project coordi- Thanks to the Lille chemical library clinical evaluation, thanks to the sup- nated by a French institution. and in partnership with Apteeus, a port of the I-SITE and the Lille task CorDial-S, Institut d’électronique, de microé- Lille-based start-up, the teams led by force fighting COVID-19. lectronique et de nanotechnologie (Institute Jean Dubuisson and Benoît Deprez ANTI SARS 2 project, Centre d’infection et of Electronics, microelectronics and nano- are repositioning existing drugs by d’immunité de Lille (CIIL) and the Medicines technology - IEMN) and Lille University testing them in vitro on both virolo- and molecules for action on living systems Hospital (CHU) gical and tissue models. This project is unit (M2SV) Contacts: Sabine Szunerits and David Devos Contacts: Jean Dubuisson and Benoît Deprez

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Planet

UNDERSTANDING GLOBAL CHANGES AND PROVIDING SOLUTIONS

The Earth is undergoing a series of changes linked to planetary activity in itself, but also to human activity impacting the environment, ecosystems and society. Researchers at the Lille site benefit from state-of-the-art equipment and pool their expertise. Objectives: to understand and predict global developments, and to develop technologies helping to limit their harmful effects.

“The research carried out within the Planet hub is multi-scale: from the atomic nucleus to the earth’s mantle; multidisciplinary: from chemistry to human and social sciences; multi-thematic: from the environment to energy; multi-techniques: from spectros- copy to catalyst reactors. Let’s bet that discoveries and innovations will be just as plentiful!”

Understanding and modelling Lionel Montagne, the team is now able to observe dislo- vice-president of research the bowels of the Earth cations of crystals using electronic at the Université de Lille Our planet is constantly undergoing microscopy on human time scales, changes and deformations in its whose translation to a macroscopic structure. They are responsible, for scale can be made on a geological example, for volcanic eruptions and time scale. earthquakes on the surface. Unders- ERC Rheoman and Timeman, Materials tanding these complex phenomena and Transformation Unit (UMET) allows for better preparation. The Contact: Patrick Cordier study of the earth’s mantle is a real experimental challenge because Deciphering and predicting the pressure and temperature the evolution of plants conditions at these depths are very How do plants choose their breeding plants. It is based on the combina- difficult to reproduce in the labora- partners when they cannot move tion of different approaches, ranging tory. With their first ERC Advanced around? How can they recognise and from mathematical modelling of Grant in 2012, entitled RheoMan, avoid being pollinated by the pollen natural selection to experimental Patrick Cordier’s team put forward they themselves have produced, manipulation via the exploration of a revolutionary approach based on when they are generally hermaphro- the dynamics of complex genomes. multi-scale simulations that allow ditic and therefore have both male ERC NOVEL, Evolution, ecology and scientists to deduce from events and and female sexual organs? The paleontology laboratory (EEP) Contact: properties on a microscopic scale, NOVEL project aims to understand Vincent Castric the behaviours observed and felt on the evolutionary processes and to a human scale. With the ERC Time- identify the molecular mechanisms Man, Patrick Cordier then turned by which a genetic system at the his attention to the problem of time heart of flowering plant reproduc- in the study of earth deformations. tion (called “self-incompatibility”) has Combining digital techniques with been able to diversify dramatically experiments on a microscopic scale, since the emergence of flowering

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Towards a revolution in chemistry, there are major scientific and techno- the backbone of the circular logical challenges in developing the economy miniaturisation of electrochemical Thanks to original scientific approaches energy storage and substantial per- (hybrid catalysis, photo- and elec- formance improvements. The teams tro-catalysis, etc.), the research teams in Lille are currently developing new, working on the RECABIO project are original and efficient micro storage proposing new ways of exploiting alter- devices. In particular, two miniaturised native resources such as bio-resources devices, Li-ion micro-batteries and 3D or plant waste so that they can effec- super micro-capacitors, complement tively replace the products produced the energy storage micro-source built by petro-resources. The approach into connected objects. The VERMINE is based on a strong collaboration 3D project uses the third dimension to between researchers in experimen- artificially increase the surface of the tal sciences and in human and social micro-devices without increasing the sciences to develop new tools. Objec- surface footprint. This technological Arabidopsis lyrata flower and genetic network tive: to develop new solutions and revolution represents a real paradigm for regulating dominance between self- evaluate their virtues (socio-economic shift in the field. It should enable incompatible alleles. and environmental impacts in particu- energy density never before achieved, lar) with regard to their technological opening the door to the energy auto- advantages. nomy of miniaturised communicating Cluster I-SITE Ressources: catalyses et electronic components of the future. bioéconomie (Resources catalysis and Project START-AIRR VERMINE 3D, Unité Better control of the nuclear risk bio-economy - RECABIO), Unité de cata- de catalyse et chimie du solide (UCCS), What happens to the radioactive ele- lyse et chimie du solide (UCCS), Institute Institute of Electronics, microelectronics of electronics, microelectronics and and nanotechnology (IEMN) ments in the event of an accident nanotechnology (IEMN), Laboratory of Contact: Christophe Lethien affecting nuclear facilities? This is the electro-technology and power electronics focal issue of the Oversee project. (L2EP), Group of studies and research, Based on globally unique approaches interdisciplinary in information and com- to multi-scale digital modelling, it munication (GERiiCO), Lille economy aims to analyse how these elements management (LEM) Contact: Robert Wojcieszak are released into the atmosphere. For example, when there is a serious Mastering energy with batteries accident in a power plant such as Fukushima or Chernobyl; in spent and miniaturised super capacitors fuel storage tanks or in fuel repro- for the electronics of the future cessing plants where fires may break Connected watches, drones, micro out in the reprocessing solvents. With sensors... more and more miniature its large nuclear stock (including the objects are emerging. They are capable Gravelines power plant in the Hauts- of interacting in a network (Internet of de-France region) and the proximity Things) to capture information in the of a reprocessing plant in The Hague, environment and respond to needs in France presents a significant nuclear the fields of health, the environment risk and volatile compounds could or the industries of the future. In order transport radioactive elements far to make them self-sufficient in power, beyond the accident site. Digital simulations of unprecedented sophis- tication will enable the Lille project to better understand the transport phe- nomena of these elements and to limit their health and environmental consequences.  I-SITE Oversee cluster, Laboratoire phy- sique des lasers, atomes et molecules (Physics Laboratory of Lasers, Atoms and Molecules - PhLAM), Physical Che- mistry of Combustion Processes and the Atmosphere Laboratory (PC2A), Unité de catalyse et chimie du solide (Catalysis and Solid Chemistry Unit - UCCS), Labex chemical and physical properties of the atmosphere (CAPPA) and CPER Climibio Contact: Valérie Valleten

imie, pivot de l’économie circu- laire Mesocentre used for computer modelling.

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Digital

TOWARDS A DIGITAL WORLD AT THE SERVICE OF SOCIETY

The digital world is transforming life in society, both individually and socially. In this context, researchers are developing disruptive digital technologies (hard and soft) by integrating advances in research in the humanities and social sciences.

would be a world first. The clus- the topological control of waves. ter benefits from the fact that Lille Cluster I-SITE Dynamics for disruptive is the only French site with both a communications and connectivity large nanotechnology centre and an (Dydico), ERC emergenTopo, Physics optical fibre manufacturing plant. It Laboratory of Lasers, Atoms and molecules (PhLAM) also participates in a joint laboratory Contact: Alberto Amo with Prysmian/Draka, the world lea- der in optical communication cables, and is supported by partnerships with Nokia and Alcatel Submarine Networks. At the user level, the mul- tiplication of connected objects and the requirements of low latency and data security necessitate the use of systems that mimic the human Artificial intelligence for analysing brain (neuromorphic calculation) for complex systems local and secure data processing. The HumAIn@Lille cluster brings Cluster I-SITE Dynamics for disruptive communications and connectivity together research excellence in statis- (Dydico), Institute of Electronics, microe- tical modelling and machine learning lectronics and nanotechnology (IEMN), to explore complex systems, with appli- Laboratoire physique des lasers, atomes cations in biology, astrophysics and et molécules (PhLAM), European Centre chemistry. The approaches developed Networks of the future for Mathematics, Physics and their Inte- in Lille make it possible, in particular, to The production and exchange of ractions (Labex CEMPI), Équipex Flux et effectively test whether a model correc- data is at the heart of our modern Excelsior Contact: Marc Lefranc tly reproduces experimental data (for societies, where increasingly mobile example, the electrical activity of heart users and intelligent objects need The topology for the creating cells) or to better analyse this data (for to be connected. Current commu- of electronics using light example, to determine in detail how a nication networks are close to their Today’s requirements for processing pair of black holes generating gravita- limits. Radically new solutions have and transporting data are increasing tional waves rotates, or to understand to be developed for tomorrow’s exponentially. However, the perfor- the functioning of areas housing stel- connectivity, both for the transmis- mance of today’s electrical circuits is lar nurseries based on observations sion and the processing of data. tending to peak. To go further, one from radio telescopes). The ambition This requires multi-scale commu- of the avenues explored by physi- is to design AI that is accepted and nication infrastructures: this is the cists is the replacement of electric integrated into human society, pro- objective of the Dydico cluster. Over currents with light or other electro- viding decisions and predictions that long distances, these infrastructures magnetic waves, for example in the are easily understood by its users and will use multi-core or multi-mode THz range. Another very promising obey ethical and legal rules. optical fibres. For short distance approach is based on “topologi- Cluster I-SITE HumAIn@Lille, IA Baccarat connections, they will use ultra- cal metamaterials”, in which these and Sherlock Chairs, ERC BlackJack, Lille high frequency wireless links in the waves propagate without loss and Centre for Research in Computer Science, TeraHertz (THz) range. As such, in are insensitive to disturbances. The Signal and Control (CRIStAL), European 2018, the Lille site set a record for emergenTopo project combines Centre for Mathematics, Physics and their transmission (100 Gbit/s). An ongoing these two approaches by exploring Interactions (Labex CEMPI) project aims to directly drive an array new avenues in topological photo- Contact: Olivier Colot of THz transmitters via a multi-core nics, and is spearheading a nascent optical fibre (see illustration), which Lille community grouped around

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splendours of the Renaissance. Tour- each individual photoreceptor (rods naments and dismounted combat, and cones) of the retina, based on wrestling matches, feasts, balls and an adaptive optics scanning laser masquerades followed one after the ophtalmoscope (AOSLO). At the other, with music as a backdrop. same time, the second study will To celebrate the 500th anniversary show how the image is subjectively of this event, which will leave a las- perceived in the brain, using innova- ting impression on memories on tive psychophysical methods. At the both sides of the Channel, the digi- same time, low energy consumption tal Cloth of Gold Camp project has neuromorphic integrated circuits undertaken to reconstruct it in 3D. are being developed from solutions The aim is to show people what inspired by living organisms. Thus, happened and to re-enact it for the start-up Axorus, developed out of public through an interactive visual the IEMN laboratory, incubated at mediation tool. It is the opportunity Eurasanté and supported by SATT for ambitious collaboration between Nord, is developing an artificial retina the human and social sciences; for based on electronic neurons, with the analysis of historical sources on the ambition of restoring the visual material culture; and for computer acuity of people suffering from reti- modelling, in particular the optical nal diseases. “The regional academic players rendering of precious ancient fabrics, Cluster: I-SITE Digital systems for are grouped around the humAIn mixing gold and silver threads. Human Knowledge (Disyknow), ANR alliance to structure and boost DEBORRA, Cognitive & Affective Cluster: I-SITE Digital systems for research in artificial intelligence Human Knowledge (Disyknow), Project Sciences Laboratory (SCALab), Institute of electronics, microelectronics and across the region, integrating inter- I-SITE VALO SHS, Institut de recherches historiques du septentrion (IRHiS), nanotechnology (IEMN), équipex IrDIVE disciplinary research based on all Equipex IrDIVE, CPER Mauve Contacts: Bilge Sayim, Virginie Hoel, the research laboratories Contact: Isabelle Paresys Alain Cappy of the Region.”

Mireille Régnier, director of the Centre Inria Lille Nord-Europe

Analysing visual perception to develop artificial retinas The precise mechanisms of human vision are not well known. Detailed History of algorithmic tissue understanding is a major challenge reconstruction from the 16th in creating artificial retinas for the century visually impaired. The Disyknow In June 1520, the meeting between cluster project is developing a new King François I and the British sove- experimental approach coupling reign Henry VIII and their courts was two types of devices. The first one the occasion for a display of unpre- uses the most precise system in the cedented luxury, emblematic of the world to study the stimulation of

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Human and social sciences

CHANGING CULTURES, SOCIETIES AND PRACTICES

The Université de Lille and the Grandes Ecoles of the Lille area are mobilising their skills and knowledge in the human and social sciences to promote an understanding of the changes that mark cultures, practices and societies. Objectives: to seize opportunities more effectively, but also to measure and control risks.

Cross-border cooperation sup- Words as a trigger for change porting social inclusion The NeoLog project is carrying out a The Franco-Belgian Interreg project, linguistic analysis of gender markers I SAID, promotes the inclusion and in the English language in order to self-determination of people with “Building on their critical tradition identify the logics of exclusion and inclusion at work in its efforts to intellectual disabilities. It aims to iden- and their openness to interdisci- tify the facilitators and obstacles they renew itself. The study looks at the plinarity, the human encounter in life, to develop response social and cognitive impact of the strategies in consultation with players and social sciences of the Lille site appearance of new gendered words in the field and to disseminate them are mobilising to understand our in English. through the training of the professio- present and imagine our future, I-SITE SHS NeoLog Project, Laboratoire nals concerned. It participates in the to identify the processes of vulne- Savoirs, Textes, Langage (STL) Contact: Maarten Lemmens construction of innovative and inte- rability that weaken individuals grated solutions within the regions and threaten social ties, and to Questioning membership involved (Hauts-de-France and Wal- build more inclusive societies on lonia). in the European Union the scale of our Region, Europe Membership in the European Union Project I SAID Interreg France- Wallonie-Vlaanderen, Laboratoire and beyond.” is a topical issue at a time when, psychologie: interactions, temps, émo- for the first time in the history of tions, cognition (Psychology Laboratory: Philippe Sabot, European integration, a Member interactions, time, emotions, cognition vice-president of research in State has left the Union. However, - PSITEC) charge of the humanities and the question of membership in this Contact: Yannick Courbois social sciences sector international organisation does not at the Université de Lille exclusively concern States. There are Lifestyles, quality of life and also issues of concern at the level of inequality in Europe the European regions, particularly In Europe, work on inequality and in the cross-border areas such as class difference is experiencing the Lille site. Finally, the disenchant- a revival, but is often confined to ment that people seem to feel with national areas only. Co-financed by the European project also raises the I-SITE and the Maison Européenne question of EU citizenship. Awar- des Sciences de l’Homme et de la Société (European Centre for the Humanities and Social Sciences - MESHS), the QUALIEUROPE project studies social inequalities at Euro- pean level and their repercussions inequalities in the quality of life and on the lifestyle and quality of life of work in Europe. The project mobi- workers. It employs a multi-facto- lises research teams in ten European rial analysis of inequalities in terms countries. of wealth, access to culture, health Project I-SITE SHS QUALIEUROPE, and public transport, quality of the Centre d’études et de recherches environment, foreign language skills, administratives politiques et sociales participation in community and poli- (CERAPS) and Centre lillois d’études et de recherches sociologiques et écono- tical life, etc. It draws on the major miques (CLERSÉ) European statistical surveys which Contacts: Étienne Pénissat and Manuel provide a detailed analysis of the Schotté

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“The strength of Lille’s research on European and international ded by the European Union, the offering a free online working tool to issues is the strength that comes Jean Monnet Chair, obtained by the the whole scientific community. from a metropolis where researcher Elsa Bernard, will support Project I-SITE EXPAND Danubius, Labo- research and take it to an internatio- ratoire histoire, archéologie et littérature borders, traffic and nal level, as well as strengthen and des mondes anciens (Laboratory of exchanges are a daily and diversify training on these issues. history, archaeology and literature of ancient worlds - HALMA) inescapable reality.” Jean Monnet Chair, Laboratory Centre Contact: Dominic Moreau for Law and Legal Perspectives (CRDP) Pierre Mathiot, Contact: Elsa Bernard director of A historical understanding of change: the archaeological and historical signs of Christianity The DANUBIUS programme, jointly funded by the I-SITE and the ANR is looking at the spread of Chris- tianity in one area of the Roman Empire (Lower Danube), during the transition between Antiquity and the Middle Ages. It brings together historians, archaeologists and geo- graphers from several European and North American countries. The The Trend(s) industrial chair to support work involves the use of computer changes in the distribution sector technologies, in particular geogra- The distribution sector in the Lille metropolitan area and the Hauts- phic information systems (GIS). The de-France Region is undergoing profound changes. To respond to the archaeological and historical signs urgency of the situation, the Trend(s) chair, launched in November of Christianity in the Late Antique 2019, is supported by an inter-disciplinary and international research Lower Danube are geo-located and team, and brings together three major retailers (Boulanger, IDKids compiled on a platform. This car- and Leroy Merlin) around four lines of research: the functions of the tography will feed the historical brick and mortar shop in an omnicommercial environment; new analysis of the different aspects of business models and emerging markets; the (re)legitimisation of the the phenomenon under study, while sector and the players in distribution in the face of consumer distrust; the organisational and cultural transformation of companies. The chair aims to produce and disseminate the knowledge co-produced by this ecosystem, using an innovative and collaborative methodo- logy. It is supported by the MEL, the I-SITE and the PICOM by Cap “The Hauts-de-France Region is Digital competitiveness cluster. both creative and fragile, rich in Trend(s) Chair, Lille school management research centre (LSMRC) Contact: Isabelle Collin-Lachaud its industrial history and cultural heritage and an exceptional site for analysis, reflection and expe- rimentation in the human and social sciences. Research in Lille is taking root in this area but is also working to better understand the challenges of a changing world and to define the conditions for a more inclusive society.”

Nil Toulouse, vice-president of research in charge of the law, economy and management sector at the Université de Lille

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A CONSORTIUM, INCUBATOR OF THE “UNIVERSITÉ DE LILLE - 2022”

The Lille Nord-Europe Excellence Initiative, led by a foundation and labelled I-SITE in February 2017 within the framework of the Investments for the Future Programme, supports the creation, on 1 January 2022, of an Experimental Public Establishment which will be named “Université de Lille” and which will bring together the current Université de Lille, Centrale Lille Institut, Sciences Po Lille, the École Supérieure de Journalisme de Lille and the École Nationale Supérieure d’Architecture et Paysage de Lille.

By strengthening the links with the development of research, and national research organisations support for training and innovation (CNRS, Inserm, Inria), the Univer- in education. It also provides finan- “The creation of the Experimental sity Hospital (CHU) and the Institut cial support for the international Public Establishment, ‘Université Pasteur de Lille, the other schools development of the Lille site and for on the site, as well as with many actions linked to the socio-economic de Lille’, will be in line with our players in the socio-economic world world. values, particularly inclusion, and and by participating in a cross-bor- will be at the very foundation of der university network (KU Leuven, our excellence.” University of Ghent and University of Kent), the ambition is to create an Jean-Christophe Camart, internationally recognised university, president capable of ranking among the top of the Université de Lille European universities. “For the past two years, the management the of I-SITE has Structuring and strategic actions been working to convince the With a budget of 15 million euros per University and the Schools of the year, the Excellence Initiative directs need to create an Experimental its funds towards structuring and Public Establishment in Lille. strategic actions, notably around This is an essential step in the confirmation of the label of excellence. I am delighted that the institutionsare now actively “For Centrale Lille Institut, the working towards this goal.” Experimental Public Establish- ment, ‘Université de Lille’, will Gilberte Chambaud, be an opportunity to develop its president of the I-SITE ULNE 190 international ambition.” COMPANIES THAT foundation SUPPORT THE PROJECT Emmanuel Duflos, director of Centrale Lille Institut

150 NATIONALITIES 2,100 PHD STUDENTS 70 RESEARCH 80,000 UNITS STUDENTS

3,500 RESEARCHERS

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ENSAIT

UNIVERSITÉ DE LILLE (6 CAMPUS)

INSTITUT PASTEUR DE LILLE

IMT CNRS LILLE-DOUAI ESJ INRIA

ENSAP

CHU ARTS ET MÉTIERS CAMPUS DE LILLE

CENTRALE LILLE INSTITUT

INSERM SCIENCES PO LILLE

Our founding establishments Université de Lille, Centrale Lille, École Nationale Supérieure des Arts et Industries Textiles, École Nationale Supérieure de Chimie de Lille, École Mines-Télécom Lille-Douai, Sciences Po Lille, École Supérieure de Journa- lisme, École Nationale Supérieure d’Architecture et de Paysage de Lille, Arts et Métiers Campus de Lille, CNRS, Inserm, Inria Lille Nord-Europe, CHU (uni- versity hospital) de Lille and Institut Pasteur de Lille.

THE MEMBERS OF THE EPE

Centrale Lille Institut, ENSAP, ESJ, Sciences Po Lille, Université de Lille.

Vivre mieux plus lon gtemps

Our founders

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