Table SI. Summary of LGI3‑regulated products from the present study and previous studies.

A, Upregulated

Arrays Official symbol Official full name

Cytokin XL arrays CCL11 C‑C motif chemokine ligand 11 CCL21 C‑C motif chemokine ligand 21 CXCL5 C‑X‑C motif chemokine ligand 5 F3 coagulation factor III, GAS6 growth arrest specific 6 TNFSF13B tumor necrosis factor superfamily member 13b Phospho explorer arrays BLNK B‑cell linker BRCA1 BRCA1, DNA repair associated BTK Bruton tyrosine CALM1 calmodulin 1 CREB1 cAMP responsive element binding 1 ERBB2 erb‑b2 2 FOXO3 forkhead box O3 GRK2 ‑coupled receptor kinase 2 IKBKB inhibitor of kappa polypeptide gene enhancer in B‑cells, kinase beta IL2RA 2 receptor subunit alpha JUN Jun proto‑oncogene, AP‑1 subunit LIMK1 LIM domain kinase 1 RELA RELA proto‑oncogene, NF‑kB subunit RPS6KA1 ribosomal protein S6 kinase A1 TP73 tumor protein p73 Signaling explorer arrays ADCK2 aarF domain containing kinase 2 AFP alpha fetoprotein CASP1 caspase 1 CD37 CD37 molecule CD80 CD80 molecule ERBB3 erb‑b2 3 ERN1 endoplasmic reticulum to nucleus signaling 1 F10 coagulation factor X F12 coagulation factor XII GAD1 glutamate decarboxylase 1 GH1 growth hormone 1 GPR151 G protein‑coupled receptor 151 LYN LYN proto‑oncogene, Src family tyrosine kinase MSTN myostatin PTGS1 prostaglandin‑endoperoxide synthase 1 PTK6 protein tyrosine kinase 6 RCBTB1 RCC1 and BTB domain containing protein 1 RPS27 ribosomal protein S27 SND1 staphylococcal nuclease and tudor domain containing 1 TUBB3 tubulin beta 3 class III TYK2 TYRO3 TYRO3 protein tyrosine kinase Explorer arrays CD63 CD63 molecule E2F2 E2F transcription factor 2 MLH1 mutL homolog 1 SEMA4D 4D SLC3A2 solute carrier family 3 member 2 Previous studies (1‑16) ADGRE1 adhesion G protein‑coupled receptor E1, EMR1, F4/80a AKT1 AKT serine/threonine kinase 1 CCL12 chemokine (C‑C motif) ligand 12b CCL2 C‑C motif chemokine ligand 2 CD68 CD68 molecule CSF3 colony stimulating factor 3 Table SI. Continued.

A, Upregulated genes

Arrays Official symbol Official full name

CTNNB1 catenin beta 1 CXCL13 C‑X‑C motif chemokine ligand 13 CXCL2 C‑X‑C motif chemokine ligand 2 CYBA cytochrome b‑245 alpha chain CYBB cytochrome b‑245 beta chain FLG IGF1 like 1 IGFBP5 insulin like growth factor binding protein 5 IL6 interleukin 6 ITGAX subunit alpha X IVL involucrin KRT10 LOR loricrin MAPK1 mitogen‑activated 1 MAPK3 mitogen‑activated protein kinase 3 MDM2 proto‑oncogene MITF melanogenesis associated transcription factor NCF1 neutrophil cytosolic factor 1 NCF2 neutrophil cytosolic factor 2 NFKB1 nuclear factor kappa B subunit 1 NOS2 nitric oxide synthase 2 PIK3CA phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit alpha PRKAA1 protein kinase AMP‑activated catalytic subunit alpha 1 PTEN phosphatase and tensin homolog PTGS2 prostaglandin‑endoperoxide synthase 2 PTK2 protein tyrosine kinase 2 TGM1 transglutaminase 1 TIMP1 TIMP metallopeptidase inhibitor 1 TNF tumor necrosis factor

B, Downregulated genes

Arrays Official symbol Official full name

Cytokine XL arrays AHSG alpha 2‑HS CCL6 chemokine (C‑C motif) ligand 6b CFD complement factor D CST3 cystatin C DPP4 dipeptidyl peptidase 4 FGF1 1 IGFBP2 insulin like growth factor binding protein 2 IGFBP6 insulin like growth factor binding protein 6 POSTN periostin PRL2C2 prolactin family 2, subfamily c, member 2b RARRES2 retinoic acid receptor responder 2 REG3G regenerating family member 3 gamma RETN resistin Phospho explorer arrays ALK anaplastic lymphoma receptor tyrosine kinase CAV1 caveolin 1 CBL Cbl proto‑oncogene CD5 CD5 molecule DOK1 docking protein 1 ESR1 estrogen receptor 1 HSP90AB1 90 alpha family class B member 1 Table SI. Continued.

B, Downregulated genes

Arrays Official symbol Official full name

IRS1 substrate 1 KIT KIT proto‑oncogene receptor tyrosine kinase KRT18 MAPK14 mitogen‑activated protein kinase 14 MTOR mechanistic target of rapamycin PDGFRA platelet derived alpha PRKCA protein kinase C alpha PRKCD protein kinase C delta RYR2 ryanodine receptor 2 STMN1 1 ZAP70 zeta chain of T cell receptor associated protein kinase 70 Signaling explorer arrays ADCK1 aarF domain containing kinase 1 AKT2 AKT serine/threonine kinase 2 AXL AXL receptor tyrosine kinase C1S complement C1s CAMKV CaM kinase like vesicle associated CD247 CD247 molecule CD3E CD3e molecule CFB complement factor B COL4A3 collagen type IV alpha 3 chain CRYAB alpha B CYP2S1 cytochrome P450 family 2 subfamily S member 1 CYP39A1 cytochrome P450 family 39 subfamily A member 1 DCC DCC netrin 1 receptor DDX4 DEAD‑box helicase 4 DNAL4 dynein axonemal light chain 4 EEF1G eukaryotic translation elongation factor 1 gamma EGF EPHB1 EPH receptor B1 EPN3 epsin 3 EXOG exo/endonuclease G F2R coagulation factor II thrombin receptor FLI1 Fli‑1 proto‑oncogene, ETS transcription factor FN1 fibronectin 1 FOXA2 forkhead box A2 KAT8 lysine acetyltransferase 8 KDR kinase insert domain receptor KLK3 kallikrein related peptidase 3 LAMC3 laminin subunit gamma 3 MATK megakaryocyte‑associated tyrosine kinase MUC16 mucin 16, cell surface associated NCR1 natural cytotoxicity triggering receptor 1 NEUROG3 neurogenin 3 NFKBIA NFKB inhibitor alpha POLR3D RNA polymerase III subunit D POU3F1 POU class 3 homeobox 1 PRPF19 pre‑mRNA processing factor 19 RCHY1 ring finger and CHY zinc finger domain containing 1 SLU7 SLU7 homolog, splicing factor SNAI2 snail family transcriptional repressor 2 TAF4 TATA‑box binding protein associated factor 4 TBP TATA‑box binding protein TP63 tumor protein p63 USP13 specific peptidase 13 Explorer arrays INSR insulin receptor MAP2K2 mitogen‑activated protein kinase kinase 2 Table SI. Continued.

B, Downregulated genes

Arrays Official symbol Official full name

Previous studies (1‑16) ADIPOQ adiponectin, C1Q and collagen domain containing BAD BCL2 associated agonist of cell death C5 complement C5 CEBPA CCAAT/enhancer binding protein alpha CRP C‑reactive protein CSF1 colony stimulating factor 1 DLK1 delta like non‑canonical Notch ligand 1 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 ESM1 endothelial cell specific molecule 1 FABP4 fatty acid binding protein 4 GSK3A glycogen synthase kinase 3 alpha GSK3B glycogen synthase kinase 3 beta IGFBP1 insulin like growth factor binding protein 1 LPL lipoprotein lipase PPARG peroxisome proliferator activated receptor gamma SERPINE1 serpin family E member 1 STX1A syntaxin 1A TP53 tumor protein p53

All the official symbols and official full names are from Organization Committee (https://www.gene‑ names.org). aPreviously named EMR1 (F4/80) (12); bMouse orthologs. Table SII. Mouse XL Cytokine Array coordinates. Table SII. Continued.

Coordinates Protein name Gene ID Coordinates Protein name Gene ID

A1 A2 Reference spotsa N/A E13 E14 GM‑CSF 12981 A3 A4 Adiponectin/Acrp30 11450 E15 E16 HGF 15234 A5 A6 11839 E17 E18 ICAM‑1/CD54 15894 A7 A8 ‑1 11600 E19 E20 IFN‑γ 15978 A9 A10 Angiopoietin‑2 11601 E21 E22 IGFBP‑1 16006 A11 A12 Angiopoietin‑like 30924 E23 E24 IGFBP‑2 16008 A13 A14 BAFF/BLyS/ 24099 F1 F2 IGFBP‑3 16009 TNFSF13B F3 F4 IGFBP‑5 16011 A15 A16 C1q R1/CD93 17064 F5 F6 IGFBP‑6 16012 A17 A18 CCL2/JE/MCP‑1 20296 F7 F8 IL‑1α/IL‑1F1 16175 A19 A20 CCL3/CCL4/MIP‑1α/β 20302/ F9 F10 IL‑1β/IL‑1F2 16176 20303 F11 F12 IL‑1ra/IL‑1F3 16181 A21 A22 CCL5/RANTES 20304 F13 F14 IL‑2 16183 A23 A24 Reference spota N/A F15 F16 IL‑3 16187 B3 B4 CCL6/C10 20305 F17 F18 IL‑4 16189 B5 B6 CCL11/Eotaxin 20292 F19 F20 IL‑5 16191 B7 B8 CCL12/MCP‑5 20293 F21 F22 IL‑6 16193 B9 B10 CCL17/TARC 20295 F23 F24 IL‑7 16196 B11 B12 CCL19/MIP‑3β 24047 G1 G2 IL‑10 16153 B13 B14 CCL20/MIP‑3α 20297 G3 G4 IL‑11 16156 B15 B16 CCL21/6Ckine 18829 G5 G6 IL‑12 p40 16160 B17 B18 CCL22/MDC 20299 G7 G8 IL‑13 16163 B19 B20 CD14 12475 G9 G10 IL‑15 16168 B21 B22 CD40/TNFRSF5 21939 G11 G12 IL‑17A 16171 C3 C4 CD160 54215 G13 G14 IL‑22 50929 C5 C6 Chemerin 71660 G15 G16 IL‑23 83430 C7 C8 Chitinase 3‑like 1 12654 G17 G18 IL‑27 p28 246779 C9 C10 Coagulation III/Tissue 14066 G19 G20 IL‑28A/B 330496/ factor 338374 C11 C12 Complement 15139 G21 G22 IL‑33 77125 Component C5/C5a G23 G24 LDL R 16835 C13 C14 Complement Factor D 11537 H1 H2 Leptin 16846 C15 C16 C‑Reactive Protein/CRP 12944 H3 H4 LIF 16878 C17 C18 CX3CL1/Fractalkine 20312 H5 H6 Lipocalin‑2/NGAL 16819 C19 C20 CXCL1/KC 14825 H7 H8 LIX 20311 C21 C22 CXCL2/MIP‑2 20310 H9 H10 M‑CSF 12977 D1 D2 CXCL9/MIG 17329 H11 H12 MMP‑2 17390 D3 D4 CXCL10/IP‑10 15945 H13 H14 MMP‑3 17392 D5 D6 CXCL11/I‑TAC 56066 H15 H16 MMP‑9 17395 D7 D8 CXCL13/BLC/BCA‑1 55985 H17 H18 Myeloperoxidase 17523 D9 D10 CXCL16 66102 H19 H20 Osteopontin (OPN) 20750 D11 D12 Cystatin C 13010 H21 H22 Osteoprotegerin/ 18383 D13 D14 DKK‑1 13380 TNFRSF11B D15 D16 DPPIV/CD26 13482 H23 H24 PD‑ECGF/Thymidine 72962 D17 D18 EGF 13645 phosphorylase D19 D20 /CD105 13805 I1 I2 PDGF‑BB 18591 D21 D22 Endostatin 12822 I3 I4 Pentraxin 2/SAP 20219 D23 D24 Fetuin A/AHSG 11625 I5 I6 Pentraxin 3/TSG‑14 19288 E1 E2 FGF 14164 I7 I8 Periostin/OSF‑2 50706 E3 E4 FGF‑21 56636 I9 I10 Pref‑1/DLK‑1/FA1 13386 E5 E6 Flt‑3 Ligand 14256 I11 I12 Proliferin 18811 E7 E8 Gas 14456 I13 I14 Proprotein 100102 E9 E10 G‑CSF 12985 Convertase 9/PCSK9 E11 E12 GDF‑15 23886 I15 I16 RAGE 11596 Table SII. Continued.

Coordinates Protein name Gene ID

I17 I18 RBP4 19662 I19 I20 Reg3G 19695 I21 I22 Resistin 57264 J1 J2 Reference spotsa N/A J3 J4 E‑/CD62E 20339 J5 J6 P‑Selectin/CD62P 20344 J7 J8 Serpin E1/PAI‑1 18787 J9 J10 Serpin F1/PEDF 20317 J11 J12 21832 J13 J14 TIM‑1/KIM‑1/HAVCR 171283 J15 J16 TNF‑α 21926 J17 J18 VCAM‑1/CD106 22329 J19 J20 VEGF 22339 J21 J22 WISP‑1/CCN4 22402 J23 J24 Negative control N/A aReference spots, included to align the transparency overlay template and to demonstrate that the array has been incubated with Streptavidin‑HRP during the assay procedure. Table SIII. KEGG pathway analysis of the gene products regulated by phosphorylation in LGI3‑treated 3T3‑ cells.

A, Gene products positively regulated by LGI3

Term Count P‑value Gene symbols hsa04722: signaling pathway 7 6.66x10‑8 RPS6KA1, RELA, JUN, FOXO3, IKBKB, TP73, CALM1 hsa04380:Osteoclast differentiation 6 4.05x10‑6 RELA, JUN, CREB1, IKBKB, BLNK, BTK hsa04662: receptor signaling pathway 5 8.60x10‑6 RELA, JUN, IKBKB, BLNK, BTK hsa04151:PI3K‑Akt signaling pathway 6 4.24x10‑4 IL2RA, RELA, CREB1, FOXO3, IKBKB, BRCA1 hsa04064:NF‑ κB signaling pathway 4 6.43x10‑4 RELA, IKBKB, BLNK, BTK hsa05215:Prostate 4 6.65x10‑4 RELA, CREB1, ERBB2, IKBKB hsa04668:TNF signaling pathway 4 1.18x10‑3 RELA, JUN, CREB1, IKBKB hsa04931:Insulin resistance 4 1.21x10‑3 RPS6KA1, RELA, CREB1, IKBKB hsa05166:HTLV‑I infection 5 1.36x10‑3 IL2RA, RELA, JUN, CREB1, IKBKB hsa05161:Hepatitis B 4 2.82x10‑3 RELA, JUN, CREB1, IKBKB hsa05030:Cocaine addiction 3 4.28x10‑3 RELA, JUN, CREB1 hsa04062:Chemokine signaling pathway 4 5.68x10‑3 RELA, FOXO3, IKBKB, GRK2 hsa04024:cAMP signaling pathway 4 6.76x10‑3 RELA, JUN, CREB1, CALM1 hsa05212:Pancreatic cancer 3 7.44x10‑3 RELA, ERBB2, IKBKB hsa05031:Amphetamine addiction 3 7.66x10‑3 JUN, CREB1, CALM1 hsa05120:Epithelial cell signaling in 3 7.89x10‑3 RELA, JUN, IKBKB Helicobacter pylori infection hsa05133:Pertussis 3 9.81x10‑3 RELA, JUN, CALM1

B, Gene products negatively regulated by LGI3

Term Count P‑value Gene symbols hsa05205:Proteoglycans in cancer 6 6.65x10‑5 PRKCA, CAV1, MAPK14, CBL, ESR1, MTOR hsa04151:PI3K‑Akt signaling pathway 6 8.51x10‑4 PRKCA, HSP90AB1, PDGFRA, KIT, MTOR, IRS1 hsa05200:Pathways in cancer 6 1.53x10‑3 PRKCA, HSP90AB1, CBL, PDGFRA, KIT, MTOR hsa05206:MicroRNAs in cancer 5 3.58x10‑3 PRKCA, PDGFRA, STMN1, MTOR, IRS1 hsa04930:Type II diabetes mellitus 3 5.38x10‑3 MTOR, IRS1, PRKCD hsa04150:mTOR signaling pathway 3 7.77x10‑3 PRKCA, MTOR, IRS1 hsa05230:Central carbon metabolism in cancer 3 9.40x10‑3 PDGFRA, KIT, MTOR hsa05214:Glioma 3 9.69x10‑3 PRKCA, PDGFRA, MTOR

KEGG, Kyoto Encyclopedia of Genes and Genomes; LGI3, leucine‑rich repeat LGI family member 3. Table SIV. Functional enrichment analysis of the gene products regulated by expression in leucine‑rich repeat LGI family member 3‑treated 3T3‑L1 cells.

A, Gene products regulated positively by LGI3

Category Term Count P‑value Gene symbols

GOTERM_BP_DIRECT GO:0007169 transmembrane 4 4.28x10‑4 TYK2, LYN, ERBB3, PTK6 receptor protein tyrosine kinase signaling pathway GOTERM_MF_DIRECT GO:0004713 protein tyrosine 5 4.10x10‑5 TYK2, TYRO3, LYN, kinase activity ERBB3, PTK6 GOTERM_MF_DIRECT GO:0004716 receptor signaling 3 9.41x10‑5 TYRO3, LYN, ERBB3 protein tyrosine kinase activity GOTERM_MF_DIRECT GO:0005515 protein binding 23 1.67x10‑4 TYRO3, E2F2, F12, F10, LYN, ERBB3, SLC3A2, MSTN, MLH1, CD63, TYK2, GH1, AFP, CD37, RPS27, CD80, PTK6, SND1, ERN1, SEMA4D, CASP1, GAD1, TUBB3 GOTERM_BP_DIRECT GO:0038083 peptidyl‑tyrosine 3 1.73x10‑3 TYK2, LYN, PTK6 autophosphorylation GOTERM_MF_DIRECT GO:0004715 non‑membrane 3 2.09x10‑3 TYK2, LYN, PTK6 spanning protein tyrosine kinase activity GOTERM_BP_DIRECT GO:0046777 protein 4 2.31x10‑3 TYRO3, LYN, PTK6, ERN1 autophosphorylation GOTERM_BP_DIRECT GO:0042127 regulation of 4 2.84x10‑3 TYK2, ERBB3, PTK6, PTGS1 cell proliferation GOTERM_CC_DIRECT GO:0031234 extrinsic 3 4.21x10‑3 TYK2, LYN, PTK6 component of cytoplasmic side of plasma membrane GOTERM_BP_DIRECT GO:0014068 positive 3 4.52x10‑3 GH1, ERBB3, SEMA4D regulation of phosphatidylinosito 3‑kinase signaling GOTERM_MF_DIRECT GO:0005524 ATP binding 8 4.86x10‑3 TYK2, TYRO3, ADCK2, LYN, ERBB3, PTK6, ERN1, MLH1 GOTERM_BP_DIRECT GO:0006468 protein 5 4.99x10‑3 TYK2, ADCK2, LYN, PTK6, ERN1 phosphorylation GOTERM_BP_DIRECT GO:0050731 positive regulation 3 7.10x10‑3 GH1, CD80, SEMA4D of peptidyl‑tyrosine phosphorylation GOTERM_MF_DIRECT GO:0005131 growth hormone 2 7.38x10‑3 TYK2, GH1 receptor binding GOTERM_CC_DIRECT GO:0042470 melanosome 3 9.06x10‑3 SND1, SLC3A2, CD63

B, Gene products regulated negatively by LGI3

Category Term Count P‑value Gene symbols

GOTERM_BP_DIRECT GO:0045893~positive regulation 10 4.98x10‑6 KAT8, TAF4, FOXA2, MAP2K2, TP63, of transcription, DNA‑templated TBP, POU3F1, EGF, INSR, F2R GOTERM_MF_DIRECT GO:0004713~protein tyrosine 6 2.39x10‑5 MAP2K2, AXL, EGF, INSR, KDR, kinase activity MATK GOTERM_BP_DIRECT GO:0018108~peptidyl‑tyrosine 6 4.28x10‑5 MAP2K2, AXL, EGF, INSR, EPHB1, phosphorylation KDR KEGG_PATHWAY hsa05200:Pathways in cancer 10 1.10x10‑4 DCC, COL4A3, LAMC3, KLK3, MAP2K2, NFKBIA, EGF, AKT2, FN1, F2R KEGG_PATHWAY hsa04151:PI3K‑Akt signaling 9 2.64x10‑4 COL4A3, LAMC3, MAP2K2, EGF, pathway INSR, KDR, AKT2, FN1, F2R Table SIV. Continued.

B, Gene products regulated negatively by LGI3

Category Term Count P‑value Gene symbols

KEGG_PATHWAY hsa05222:Small cell lung cancer 5 8.49x10‑4 COL4A3, LAMC3, NFKBIA, AKT2, FN1 KEGG_PATHWAY hsa05215:Prostate cancer 5 9.67x10‑4 KLK3, MAP2K2, NFKBIA, EGF, AKT2 GOTERM_CC_DIRECT GO:0005576~extracellular region 12 1.00x10‑3 COL4A3, ADCK1, LAMC3, KLK3, CFB, MAP2K2, C1S, EGF, EPHB1, KDR, FN1, F2R GOTERM_CC_DIRECT GO:0000790~nuclear chromatin 5 1.09x10‑3 TAF4, TP63, TBP, SNAI2, POLR3D GOTERM_BP_DIRECT GO:0030335~positive regulation 5 1.23x10‑3 SNAI2, INSR, KDR, AKT2, F2R of cell migration GOTERM_MF_DIRECT GO:0005515~protein binding 34 1.53x10‑3 DCC, CYP2S1, CD247, NFKBIA, TP63, TBP, C1S, EPHB1, PRPF19, FLI1, RCHY1, EGF, INSR, USP13, AKT2, MATK, FN1, KAT8, EPN3, COL4A3, TAF4, KLK3, MAP2K2, CRYAB, CD3E, AXL, NEUROG3, SNAI2, KDR, SLU7, EEF1G, DNAL4, MUC16, F2R KEGG_PATHWAY hsa04660:T cell receptor signaling 5 1.56x10‑3 CD3E, MAP2K2, CD247, NFKBIA, pathway AKT2 GOTERM_BP_DIRECT GO:0007169~transmembrane 4 1.89x10‑3 CD3E, INSR, KDR, MATK receptor protein tyrosine kinase signaling pathway KEGG_PATHWAY hsa04510:Focal adhesion 6 3.58x10‑3 COL4A3, LAMC3, EGF, KDR, AKT2, FN1 KEGG_PATHWAY hsa04015:Rap1 signaling pathway 6 3.89x10‑3 MAP2K2, EGF, INSR, KDR, AKT2, F2R GOTERM_MF_DIRECT GO:0004714~transmembrane 3 4.40x10‑3 AXL, INSR, KDR receptor protein tyrosine kinase activity GOTERM_BP_DIRECT GO:0038083~peptidyl‑tyrosine 3 4.70x10‑3 INSR, KDR, MATK autophosphorylation GOTERM_MF_DIRECT GO:0008134~transcription factor 5 6.28x10‑3 KAT8, TAF4, FOXA2, NFKBIA, TBP binding GOTERM_BP_DIRECT GO:0008284~positive regulation 6 6.51x10‑3 EGF, INSR, KDR, FN1, F2R, MATK of cell proliferation GOTERM_BP_DIRECT GO:0016032~viral process 5 7.04x10‑3 TAF4, CD247, NFKBIA, TBP, KDR Table SV. Transcription factor affinity prediction of the genes included in the inner circular subnetwork of cytokines, adipokines and chemokines that are presented in Fig. 3.

Rank Matrix Transcription factor Association score P‑value

1 NFKB_C N/A 5.616 5.00x10‑5 2 NFKB_Q6_01 Nf‑κb1, Nf‑κb2 5.389 8.40x10‑5 3 NFKAPPAB65_01 Rela 4.934 2.34x10‑4 4 CREL_01 C‑rel 4.753 3.19x10‑4 5 NFKB_Q6 N/A 4.699 3.44x10‑4 6 NFKAPPAB_01 Rela 4.374 7.23x10‑4 7 CEBP_Q2 C/ebp, C/ebpα 3.772 2.53x10‑3 8 PAX8_01 Pax‑8 3.682 3.03x10‑3 9 TFIIA_Q6 Tfiia‑α/β, Tfiia‑γ 3.648 3.30x10‑3 10 TATA_C Tbp 3.584 3.78x10‑3 11 NKX62_Q2 Nkx6‑2 3.486 4.53x10‑3 12 SPZ1_01 Spz1 3.393 5.53x10‑3 13 MTATA_B N/A 3.359 5.80x10‑3 14 PAX8_B Pax‑8 3.317 6.17x10‑3 15 HNF1_01 Hnf‑1α, Hnf‑1α‑a 3.123 9.51x10‑3 16 HNF1_Q6 Hnf‑1α, Hnf‑1α‑a 3.123 9.51x10‑3 17 HNF1_Q6_01 Hnf‑1α, Hnf‑1α‑a 3.123 9.51x10‑3 18 LMO2COM_02 Lmo2 3.123 9.51x10‑3 19 BARBIE_01 N/A 3.093 9.84x10‑3

N/A, sequence motifs with no transcription factors identified.