Curriculum Vitae

Date Prepared: 03/25/2020 Name: Konstantin Deutsch Office Address: Boston Children’s Hospital

Hildebrandt Laboratory

Enders Room 570

300 Longwood Ave

Boston, MA 02115 Home Address: 10 Akron Street, Apt. 212 Cambridge, MA 02138 Work Phone: 617-919-9980 Work Email: [email protected] Work FAX: Place of Birth: Wismar

Education:

11/2015 State exam Medicine Hannover Medical School 05/2018 MD Medicine Hannover Medical School The Jackson Laboratory Mount Desert Island Biological Laboratory

Postdoctoral Training:

Since Resident and Internal Medicine and Hannover Medical School 01/2016 Assistant Physician Nephrology (Postdoctoral advisor: Prof. Dr. Mario Schiffer)

Since Postdoctoral research Internal Medicine and Boston Children’s 07/2018 fellow Nephrology (Postdoctoral Hospital advisor: Prof. Dr. Friedhelm Hildebrandt)

Appointments at Hospitals/Affiliated Institutions:

Since Resident and Internal Medicine and Hannover Medical School 01/2016 Assistant Physician Nephrology

Since Postdoctoral research Internal Medicine and Boston Children’s 07/2018 fellow Nephrology Hospital

Professional Societies:

Since German Society of Internal Medicine Member 01/2016

Since American Society of Nephrology Member 05/2019

Editorial Activities:

• Ad hoc Reviewer o Nature Communications o Journal of the American Society of Nephrology

Honors and Prizes:

2019 Advances in Research American Society of Nephrology Conference Travel Award

2 Report of Funded and Unfunded Projects Funding Information: Past

07/2011 to Role of Kynurenine 3-monooxygenase (KMO) for the Integrity of the Glomerular 05/2012 Filtration Barrier Research scholarship from German Academic Exchange Council (DAAD) Student in doctorate; PIs: Prof. Dr. med. Mario Schiffer, Ron Korstanje PhD This project aimed to investigate the role of a decrease in KMO activity as a potential contributor to development of nephrotic range proteinuria. Unfunded Current Projects

Since Identification of novel monogenic causes of steroid resistant nephrotic syndrome by 07/2018 whole exome sequencing Postdoctoral Research Fellow Identification of potential novel monogenic causes of steroid resistant nephrotic syndrome by performing whole exome sequencing on a study population of 2000 pediatric patients and and subsequent functional delineation of the pathophysiology

Since Mutations in Diaphanous Related Formins (DRF) cause nephrotic syndrome 07/2018 Postdoctoral Research Fellow Delineation of the pathophysiology of mutations causative of nephrotic syndrome in the Diaphanous Related Formins, a family of important actin modulators

Since Novel approaches to CRISPR/Cas9 mediated knockout in zebrafish 08/2019 Postdoctoral Research Fellow Establishment of novel knockout techniques using the CRISPR/Cas9 system in zebrafish to circumvent phenotypic rescue due to nonsense mediated decay in zebrafish

3 Report of Local Teaching and Training Teaching of Students in Courses:

01/2016 to Clinical skills Hannover Medical School 04/2018 2nd year medical students Two hours per week for eight weeks 01/2016 to Internal medicine Hannover Medical School 04/2018 4th year medical students 20 hours per week for three weeks 10/2017 Abdominal ultrasound imaging Hannover Medical School 4th year medical students 10 hours for one week

Formal Teaching of Peers (e.g., CME and other continuing education courses): No presentations below were sponsored by outside entities Those presentations below sponsored by outside entities are so noted and the sponsor(s) is (are) identified.

01/2016 to Internal medicine CME Regular presentations 04/2018 Hannover Medical School CME Hannover

Report of Clinical Activities and Innovations Current Licensure and Certification:

11/2015 German Medical License (Approbation)

Practice Activities:

01/2016 to Ward Physician Division of Nephrology and 42 hours per week 11/2016 Hypertensiology, Department of Internal Medicine, Hannover Medical School 11/2016 to Ambulatory Dialysis KfH Dialysis, Hannover 42 hours per week 04/2017 04/2017 to Intensive Care Unit Deister-Süntel-Klinik, Bad 42 hours per week 10/2017 Münder 10/2017 to Emergency Room Emergency Room, Department of 42 hours per week 04/2018 Internal Medicine, Hannover Medical School

4 Report of Scholarship

Peer-Reviewed Scholarship in print or other media:

Research Investigations

Korstanje R*, Deutsch K*, Bolanos-Palmieri P, et al. Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria. J Am Soc Nephrol 2016;27(11):3271–7.

Greite R*, Deutsch K*, Bräsen JH, von Vietinghoff S. Azathioprine hypersensitivity syndrome in anti- myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis. Clin Kidney J. 2019 Feb;12(1):89-91.

* shared first-authorship

Thesis:

Role of Kynurenine 3-Monooxygenase (KMO) for the Integrity of the Glomerular Filtration Barrier

Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings:

Deutsch K, Schneider R, Kitzler TM, Jobst-Schwan T, Colvenbach C, Kause F, Hildebrandt F: CRISPR/Cas9 Zebrafish Models Do Not Recapitulate 4 Human Monogenic Causes of Nephrotic Syndrome [Abstract] J Am Soc Nephrol 30, 2019:327

Schneider R, Deutsch K, Hoeprich G, Braun DA, Kitzler TM, Mao Y, Majmundar A, Buerger F, Wagner M, Riedhammer KM, Renders L, Shril S, Hoefele J, Hildebrandt F: Mutations in the Diaphanous Related Formin DAAM2 as a Novel Cause of Nephrotic Syndrome [Abstract] J Am Soc Nephrol 30, 2019:643-644

Buerger F, Majmundar A, Klambt V, Schneider R, Deutsch K, Onuchic-Whitford A, Kitzler TM, Mao Y, Ashraf S, Shril S, Hildebrandt F: Nos1ap-/- Mice Replicate the Human Nephrotic Syndrome Phenotype Potentially via a CDC42-Diaphanous-Related Mechanism [Abstract] J Am Soc Nephrol 30, 2019:643

Onuchic-Whitford A, Klambt V, Buerger F, Majmundar A, Ashraf S, Schneider R, Deutsch K, Mao Y, Lim TY, Sanna-Cherchi S, Shril S, Hildebrandt F: Recessive Mutations in Bassoon (BSN) Are a Potential New Cause of Nephrotic Syndrome [Abstract] J Am Soc Nephrol 30, 2019:644

Kitzler TM, Schneider R, Deutsch K, Mao Y, Ashraf S, Klambt V, Majmundar A, Buerger F, Onuchik- Whitford A, Cifuentes IM, Lou-Meda RM, Aguilar AL, Soliman N, Bagga A, Shril S, Hildebrandt F: Recessive Mutations in TNS1 Are a Potential Novel Cause of Nephrotic Syndrome [Abstract] J Am Soc Nephrol 30, 2019:644

Mao Y, Schneider R, Ashraf S, Majmundar A, Klambt V, Kitzler TM, Nakayama M, Buerger F, Deutsch K, Onuchik-Whitford A, Shamseldin HE, Alkuraya FS, Fathy H, Shril S, Hildebrandt F:

5 Recessive Mutations in SYNPO2 May Cause Nephrotic Syndrome via Mesangial Cell Dysfunction [Abstract] J Am Soc Nephrol 30, 2019:644