Product Datasheet

LGMN Polyclonal Antibody

Catalog No: #27479

Package Size: #27479-1 50ul #27479-2 100ul Orders: [email protected] Support: [email protected]

Description

Product Name LGMN Polyclonal Antibody

Host Species Rabbit

Clonality Polyclonal

Isotype IgG

Purification Affinity purification

Applications WB,IF

Species Reactivity Hu,Ms,Rt

Immunogen Description Recombinant fusion of human LGMN (NP_001008530.1).

Other Names LGMN; AEP; LGMN1; PRSC1; legumain

Accession No. Swiss-Prot#:Q99538NCBI ID:5641

Calculated MW 54kDa

Formulation Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage Store at -20°C

Application Details

WB 1:1000 - 1:2000IF 1:50 - 1:200

Images

Western blot analysis of extracts of various cell lines, using LGMN antibody.

Immunofluorescence analysis of C6 cells using LGMN Polyclonal Antibody.

Address: 8400 Baltimore Ave. Suite 302 College Park MD 20740 USA http://www.sabbiotech.com 1 Immunofluorescence analysis of HeLa cells using LGMN Polyclonal Antibody.

Immunofluorescence analysis of L929 cells using LGMN Polyclonal Antibody.

Background

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a on 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Note: This product is for in vitro research use only and is not intended for use in humans or animals.

Address: 8400 Baltimore Ave. Suite 302 College Park MD 20740 USA http://www.sabbiotech.com 2