Issue Highlights: Editor's Note: Editorials: Original Articles: Cardiovascular Surgery

Total Page:16

File Type:pdf, Size:1020Kb

Issue Highlights: Editor's Note: Editorials: Original Articles: Cardiovascular Surgery Contents:Volume 112, Issue 1; July 5, 2005 Issue Highlights: Issue Highlights Circulation 2005 112: 1 Editor's Note: Editor’s Note Joseph Loscalzo Circulation 2005 112: 2, Editorials: Endothelial Progenitor Cells, Neointimal Hyperplasia, and Hemodialysis Vascular Access Dysfunction: Novel Therapies for a Recalcitrant Clinical Problem Prabir Roy-Chaudhury Circulation 2005 112: 3 - 5, Cell Death and Adenosine Triphosphate: The Paradox Jutta Schaper and Sawa Kostin Circulation 2005 112: 6 - 8, N-Terminal-Pro-B–Type Natriuretic Peptide: Universal Marker of Cardiovascular Risk? A. Mark Richards and Christopher M. Frampton Circulation 2005 112: 9 - 11, Original Articles: Cardiovascular Surgery: gfedc In Vivo Cell Seeding With Anti-CD34 Antibodies Successfully Accelerates Endothelialization but Stimulates Intimal Hyperplasia in Porcine Arteriovenous Expanded Polytetrafluoroethylene Grafts Joris I. Rotmans, Jan M.M. Heyligers, Hence J.M. Verhagen, Evelyn Velema, Machiel M. Nagtegaal, Dominique P.V. de Kleijn, Flip G. de Groot, Erik S.G. Stroes, and Gerard Pasterkamp Circulation 2005 112: 12 - 18; published online before print June 27 2005, Coronary Heart Disease: gfedc Periodontal Disease and Coronary Heart Disease: A Reappraisal of the Exposure James D. Beck, Paul Eke, Gerardo Heiss, Phoebus Madianos, David Couper, Dongming Lin, Kevin Moss, John Elter, and Steven Offenbacher Circulation 2005 112: 19 - 24; published online before print June 27 2005, gfedc C-Reactive Protein and the 10-Year Incidence of Coronary Heart Disease in Older Men and Women: The Cardiovascular Health Study Mary Cushman, Alice M. Arnold, Bruce M. Psaty, Teri A. Manolio, Lewis H. Kuller, Gregory L. Burke, Joseph F. Polak, and Russell P. Tracy Circulation 2005 112: 25 - 31; published online before print June 27 2005, Epidemiology: gfedc Obesity, Insulin Resistance, and the Metabolic Syndrome: Determinants of Endothelial Dysfunction in Whites and Blacks A.A. Lteif, K. Han, and K.J. Mather Circulation 2005 112: 32 - 38; published online before print June 27 2005, Health Services and Outcomes Research: gfedc Adoption of Spironolactone Therapy for Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction in the United States, 1998–2001 Frederick A. Masoudi, Cary P. Gross, Yongfei Wang, Saif S. Rathore, Edward P. Havranek, JoAnne Micale Foody, and Harlan M. Krumholz Circulation 2005 112: 39 - 47; published online before print June 27 2005, Heart Failure: gfedc Effects of Candesartan on the Development of a New Diagnosis of Diabetes Mellitus in Patients With Heart Failure Salim Yusuf, Jan B. Ostergren, Hertzel C. Gerstein, Marc A. Pfeffer, Karl Swedberg, Christopher B. Granger, Bertil Olofsson, Jeffrey Probstfield, John V. McMurray on behalf of the Candesartan in Heart Failure—Assessment of Reduction in Mortality and Morbidity Program (CHARM) Investigators Circulation 2005 112: 48 - 53; published online before print June 27 2005, gfedc -Myosin Heavy Chain: A Sarcomeric Gene Associated With Dilated and Hypertrophic Phenotypes of Cardiomyopathy Elisa Carniel, Matthew R.G. Taylor, Gianfranco Sinagra, Andrea Di Lenarda, Lisa Ku, Pamela R. Fain, Mark M. Boucek, Jean Cavanaugh, Snjezana Miocic, Dobromir Slavov, Sharon L. Graw, Jennie Feiger, Xiao Zhong Zhu, Dmi Dao, Debra A. Ferguson, Michael R. Bristow, and Luisa Mestroni Circulation 2005 112: 54 - 59, Hypertension: gfedc Elevated Blood Pressure Linked to Primary Hyperaldosteronism and Impaired Vasodilation in BK Channel–Deficient Mice Matthias Sausbier, Claudia Arntz, Iancu Bucurenciu, Hong Zhao, Xiao-Bo Zhou, Ulrike Sausbier, Susanne Feil, Simone Kamm, Kyrill Essin, Claudia A. Sailer, Usamah Abdullah, Peter Krippeit-Drews, Robert Feil, Franz Hofmann, Hans-Günther Knaus, Chris Kenyon, Michael J. Shipston, Johan F. Storm, Winfried Neuhuber, Michael Korth, Rudolf Schubert, Maik Gollasch, and Peter Ruth Circulation 2005 112: 60 - 68; published online before print May 2 2005, Imaging: gfedc Risk of Embolism and Death in Infective Endocarditis: Prognostic Value of Echocardiography: A Prospective Multicenter Study Franck Thuny, Giovanni Disalvo, Olivier Belliard, Jean-François Avierinos, Valeria Pergola, Valerie Rosenberg, Jean-Paul Casalta, Joanny Gouvernet, Geneviève Derumeaux, Diana Iarussi, Pierre Ambrosi, Raffaello Calabro, Alberto Riberi, Frédéric Collart, Dominique Metras, Hubert Lepidi, Didier Raoult, Jean-Robert Harle, Pierre-Jean Weiller, Ariel Cohen, and Gilbert Habib Circulation 2005 112: 69 - 75; published online before print June 27 2005, Molecular Cardiology: gfedc Bcl-xL Gene Transfer Inhibits Bax Translocation and Prolongs Cardiac Cold Preservation Time in Rats Jianhua Huang, Kiminori Nakamura, Yoshinori Ito, Takeshi Uzuka, Masayuki Morikawa, Sachie Hirai, Kei Tomihara, Toshihiro Tanaka, Yukari Masuta, Keiji Ishii, Kazunori Kato, and Hirofumi Hamada Circulation 2005 112: 76 - 83; published online before print June 27 2005, gfedc Augmented Cardiac Hypertrophy in Response to Pressure Overload in Mice Lacking the Prostaglandin I2 Receptor Akiyoshi Hara, Koh-ichi Yuhki, Takayuki Fujino, Takehiro Yamada, Koji Takayama, Shuhko Kuriyama, Osamu Takahata, Hideji Karibe, Yuji Okada, Chun-Yang Xiao, Hong Ma, Shuh Narumiya, and Fumitaka Ushikubi Circulation 2005 112: 84 - 92; published online before print June 27 2005, gfedc Neuronal Nitric Oxide Synthase Mediates Statin-Induced Restoration of Vasa Nervorum and Reversal of Diabetic Neuropathy Masaaki Ii, Hiromi Nishimura, Kengo F. Kusano, Gangjian Qin, Young-sup Yoon, Andrea Wecker, Takayuki Asahara, and Douglas W. Losordo Circulation 2005 112: 93 - 102; published online before print June 27 2005, Pediatric Cardiology: gfedc Early Structural and Functional Changes of the Vasculature in HIV-Infected Children: Impact of Disease and Antiretroviral Therapy Marietta Charakida, Ann E. Donald, Hannah Green, Clare Storry, Margaret Clapson, Muriel Caslake, David T. Dunn, Julian P. Halcox, Diana M. Gibb, Nigel J. Klein, and John E. Deanfield Circulation 2005 112: 103 - 109; published online before print June 27 2005, Stroke: gfedc Prediction of Myocardial Infarction by N-Terminal-Pro-B-Type Natriuretic Peptide, C-Reactive Protein, and Renin in Subjects With Cerebrovascular Disease Duncan J. Campbell, Mark Woodward, John P. Chalmers, Samuel A. Colman, Alicia J. Jenkins, Bruce E. Kemp, Bruce C. Neal, Anushka Patel, and Stephen W. MacMahon Circulation 2005 112: 110 - 116; published online before print June 27 2005, Vascular Medicine: gfedc Statin Treatment After Onset of Sepsis in a Murine Model Improves Survival Marc W. Merx, Elisa A. Liehn, Jürgen Graf, Annette van de Sandt, Maren Schaltenbrand, Jürgen Schrader, Peter Hanrath, and Christian Weber Circulation 2005 112: 117 - 124, Contemporary Reviews in Cardiovascular Medicine: gfedc Valvular Heart Disease: Aortic Regurgitation Raffi Bekeredjian and Paul A. Grayburn Circulation 2005 112: 125 - 134, New Drugs and Technologies: Frontiers in Cardiovascular Magnetic Resonance Valentin Fuster and Raymond J. Kim Circulation 2005 112: 135 - 144, Special Reports: A Vision for the Future: Opportunities and Challenges: Notes From the Director of the National Heart, Lung, and Blood Institute Elizabeth G. Nabel Circulation 2005 112: 145 - 146, Images in Cardiovascular Medicine: Detection of Luminal-Intimal Border and Coronary Wall Enhancement in Intravascular Ultrasound Imaging After Injection of Microbubbles and Simultaneous Sonication With Transthoracic Echocardiography Manolis Vavuranakis, Ioannis A. Kakadiaris, Sean M. O’Malley, Christodoulos Stefanadis, Sophia Vaina, Maria Drakopoulou, Ioannis Mitropoulos, Stephane Carlier, and Morteza Naghavi Circulation 2005 112: e1 - e2, Detection of Carotid Atherosclerotic Plaque Ulceration, Calcification, and Thrombosis by Multicontrast Weighted Magnetic Resonance Imaging Baocheng Chu, Marina S. Ferguson, Hunter Underhill, Norihide Takaya, Jianming Cai, Michel Kliot, Chun Yuan, and Thomas S. Hatsukami Circulation 2005 112: e3 - e4, Primary Lymphoma of the Heart Jeffrey Kuvin, Nisha Parikh, Robert Salomon, Arthur Tischler, Philip Daoust, Yevgeniy Arshanskiy, Karl Coyner, Philip Carpino, Natesa G. Pandian, Carey Kimmelstiel, Caroline Foote, John Erban, and Hassan Rastegar Circulation 2005 112: e5 - e6, Correspondence: Letter Regarding Article by McNair et al, "SCN5A Mutation Associated With Dilated Cardiomyopathy, Conduction Disorder, and Arrhythmia" • Response W.A. Groenewegen, A.A.M. Wilde, William P. McNair, Lisa Ku, Matthew R.G. Taylor, Pam R. Fain, Eugene Wolfel, and Luisa Mestroni Circulation 2005 112: e9 - e10, Letter Regarding Article by Galbreath et al, "Long-Term Healthcare and Cost Outcomes of Disease Management in a Large, Randomized, Community-Based Population With Heart Failure" • Response Ariel Linden, Thomas Wilson, Autumn Dawn Galbreath, Gregory L. Freeman, Brad Smith, Richard A. Krasuski, Karl C. Stajduhar, Michael D. Kwan, and Robert Ellis Circulation 2005 112: e11, Book Reviews: Computed Tomography of the Coronary Arteries Frederick L. Ruberg Circulation 2005 112: e7 - e8, Acknowledgment of Reviewers: Acknowledgment of Reviewers Circulation 2005 112: e12 - e26, Circulation JOURNAL OF THE AMERICAN HEART ASSOCIATION IIssssuuee HHiigghhlliigghhttss Vol 111, No 1, July 5, 2005 PERIODONTAL DISEASE AND CORONARY HEART STATIN TREATMENT AFTER ONSET OF SEPSIS IN DISEASE: A REAPPRAISAL OF THE EXPOSURE, by A MURINE MODEL IMPROVES SURVIVAL, by Merx Beck et al. et al. There currently is great interest in understanding the role of certain The clinical benefits achieved with
Recommended publications
  • American Heart Association Preview 2017.Pdf
    NovemberNovember 11-15 11-15 Anaheim,Anaheim, California California PREVIEWTHE IN CLASS CARDIOVASCULAR CONFERENCE EDUCATIONAL SESSIONS FOR ALL CAREER STAGES WITH GLOBAL THOUGHT LEADERS innovative FACULTY PROVIDING INTERACTIVE, network PERSONALIZED EDUCATION world- renowned PAID ADVERTISEMENT PICK UP A FREE COPY AT: AHA HeartQuarters, booth #355 Wolters Kluwer, booth #439 Wiley, booth #545 FIND THE ENTIRE AHA /ASA JOURNALS’ TREND WATCH COLLECTION ONLINE DOWNLOAD ALL 3 ISSUES TODAY! Freely 450+ Available Articles INTERACTIVE MAGAZINE DOWNLOAD THE BLIPPAR APP App required for free, full-text Download the latest issue and view access to Trend Watch. a video demonstration at AVAILABLE ON www.ahajournals.org/site/trendwatch American Heart Association American Heart Association National Center 7272 Greenville Ave. Dallas, TX 75231 214-373-6300 800-242-2453 professional.heart.org Registration INSIDE Convention Data Services 107 Waterhouse Road THE PREVIEW Bourne, MA 02532 800-748-3583 (inside U.S.) 508-743-8517 (outside U.S.) Join the [email protected] AHA Scientific Sessions 2017 conversation Housing 2 Welcome from the program chair onPeak 4 What’s hot at AHA Scientific Sessions 2017 381 Park Ave. S., Third Floor 6 Expect the best in 2017 New York, NY 10 Week at a glance facebook.com/ 800-221-3531 (inside U.S.) ahameetings 312-527-7300 (outside U.S.) [email protected] Advance programming and faculty Facility Anaheim Convention Center 14 Programming information and schedule @AHAmeetings 800 W. Katella Ave. #AHA17 Anaheim, CA 92802 14 CE/CME
    [Show full text]
  • Omega-3 Fatty Acids and Their Role in Cardiac Arrhythmogenesis Workshop Research Challenges and Opportunities
    National Heart, Lung, and Blood Institute and the Office of Dietary Supplements National Institutes of Health Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop Research Challenges and Opportunities August 29-30, 2005 Embassy Suites Hotel at the Chevy Chase Pavilion 4300 Military Road, NW Washington, District of Columbia 20015 AGENDA Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop: Research Challenges and Opportunities Day 1: Monday, August 29, 2005 9:00 a.m. Call to Order 9:30 a.m. Welcome and Opening Remarks Dr. David Lathrop Dr. Rebecca Costello 9:35 a.m. Workingshop Goals and Objectives Dr. Barry London (Chair) Session I - Background: Evidence for Antiarrhythmic Effects of Omega-3 (n-3) Fatty Acids 9:50 a.m. Evidence for Antiarrhythmic Effects from Epidemiologic Dr. Christine Albert Studies 10:20 a.m. Agency for Healthcare Research and Quality Dr. Ethan Balk (AHRQ): Evidence Reports on the Cardiovascular Ms. Mei Chung Effects of n-3 Fatty Acids 10:50 a.m. Discussion All Participants 11:05 a.m. Break . Session II –NHLBI-supported Trials to Determine the Antiarrhythmic Effects of n-3 Fatty Acids 11:15 a.m. The Fatty Acid Antiarrhythmia Trial (FATT) (R01 Dr. Alexander Leaf HL062154) 11:55 a.m. The Antiarrhythmic Effects of n-3 Fatty Acids Study (R01 Dr. John McAnulty HL061682) 12:35 p.m. Discussion All Participants 12:50 p.m. Lunch Session III – Possible Basic Mechanisms of Action 1:50 p.m. Dietary Source of n-3 Fatty Acids: Metabolic Pathways Dr. Bill Lands and Sites of Interaction 2:20 p.m.
    [Show full text]
  • Remodeling of Myocardial Passive Electrical Properties: Insights Into the Mechanisms of Malignant Arrhythmias and Sudden Cardiac Death
    Remodeling of Myocardial Passive Electrical Properties: Insights into the Mechanisms of Malignant Arrhythmias and Sudden Cardiac Death. DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Carlos Luis del Rio, M.S. Graduate Program in Electrical and Computer Science The Ohio State University 2015 Dissertation Committee: Professor Bradley D. Clymer, Ph.D., Advisor Professor George E. Billman, Ph.D., Co-Advisor Professor Furrukh S. Khan, Ph.D. Copyright by Carlos Luis del Rio 2015 Abstract Despite extensive research, sudden cardiac death (SCD) resulting from ischemia-induced malignant arrhythmias, such as ventricular fibrillation (VF), remains a leading cause of death, particularly following myocardial infarction (MI). Furthermore, SCD is generally the first and most common manifestation of the disease, as current risk-stratifying tools are inaccurate and insufficient. Acute/chronic changes in the passive electrical properties governing electrotonic coupling in the myocardium have been proposed as a potential mechanism mediating both the onset and maintenance of arrhythmias, as the loss of homogenizing electrotonic coupling can exacerbate intrinsic pro-arrhythmic electrical heterogeneities within the ventricle, especially during repolarization. However, no study to date has assessed the ability of indices reflective of electrotonic changes to stratify intrinsic arrhythmic susceptibility in vivo. Leveraging a well-established in vivo post-MI canine model of SCD and lethal arrhythmias, this research work investigates the pro-arrhythmic role of changes in the passive electrical properties of the myocardium, as measured by its complex electrical impedance spectrum (MEI). The studies were performed under the general hypothesis that the loss of electrotonic coupling accompanies and facilitates the development of malignant arrhythmias in the setting of ischemia and post-MI ventricular/autonomic remodeling.
    [Show full text]
  • Research Digest
    ERD Examine.com Research Digest Issue 7 ◆ May 2015 1 Table of Contents 05 Going nuts over infant peanut exposure Randomized trial of peanut consumption in infants at risk for peanut allergy 13 How the Food Industry Spins Science to Fit Its Agenda By Andy Bellatti, MS, RD 16 Non-celiac gluten sensitivity: much ado about something? Small Amounts of Gluten in Subjects with Suspected Nonceliac Gluten Sensitivity: a Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial 23 Baby probiotics for prevention of ADHD and Asperger’s A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial 31 Putting the “D” in Death A reverse J-shaped association between serum 25- hydroxyvitamin D and cardio- vascular disease mortality – the CopD-study 40 Eggcellent Eggs: Is it safe for people with diabetes to eat a lot of eggs? The effect of a high-egg diet on cardiovascular risk factors in people with type 2 dia- betes: the Diabetes and Egg (DIABEGG) study—a 3-mo randomized controlled trial 46 Do BCAAs and arginine prevent central fatigue during exercise? Branched-chain amino acids and arginine improve performance in two consecutive days of simulated handball games in male and female athletes: a randomized trial 52 HMB-elly be gone β-Hydroxy-β-methylbutyrate (HMB) supplementation and resistance exercise sig- nificantly reduce abdominal adiposity in healthy elderly men 58 Spicing up your workout Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS) 65 INTERVIEW: Shawn Wells, MPH, RD 71 Ask the Researcher: James Heathers, Ph.D.
    [Show full text]
  • Relengthening RT50, Fig 3C-G)
    Neuronal Nitric Oxide Synthase Signaling Contributes to the Beneficial Cardiac Effects of Exercise DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Steve R. Roof Biomedical Sciences Graduate Program The Ohio State University 2012 Dissertation Committee: Dr. Mark T. Ziolo, PhD Advisor Dr. George E. Billman, PhD Dr. Sandor Gyorke, PhD Dr. Brandon Biesidecki, PhD ABSTRACT Exercise is beneficial to one’s health, reduces the risk of cardiomyopathies, and is utilized as a therapeutic intervention after disease [2-7]. This is due, in part, due to the beneficial chronic adaptations that enhance contraction and accelerate relaxation [8]. These intrinsic exercise-induced adaptations are observed at the level of the cardiomyocyte [9]. That is, ventricular myocytes from exercised (Ex) mice exhibit increased Ca2+ cycling and contraction-relaxation rates [6, 9-12]. Additionally, cardiac growth (physiological hypertrophy) and an increase in aerobic fitness (VO2max) are hallmark cardiac adaptations due to exercise training. The molecular mechanisms that explain how the heart adapts are not fully understood and studies examining signaling pathways are limited. A signaling molecule with a potential role in cardiac adaptations to exercise is nitric oxide (NO). Nitric Oxide (NO) has been shown to be a key regulator of myocyte contractile function. NO, produced via the neuronal nitric oxide synthase (nNOS or NOS1), enhances basal contraction by increasing Ca2+ cycling through the sarcoplasmic reticulum (SR) [13-15]. Data suggest that NOS1 signaling increases Ca2+ uptake by targeting the SR Ca2+ ATPase (SERCA2a)/phospholamban (PLB) complex. NOS1 signaling also targets the SR Ca2+ release channel (ryanodine receptor - RYR2) to increase its open time probability [16].
    [Show full text]
  • Regulation of Cardiac Voltage Gated Potassium Currents in Health and Disease
    REGULATION OF CARDIAC VOLTAGE GATED POTASSIUM CURRENTS IN HEALTH AND DISEASE DISSERTATION Presented in Partial Fulfillment of the Requirements for The Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Arun Sridhar, M.S. ****** The Ohio State University 2007 Dissertation Committee: Dr. Cynthia A. Carnes, Pharm.D, PhD Approved By: Dr. Robert L. Hamlin, DVM, PhD ______________________ Dr. Sandor Gyorke, PhD Advisor Dr. Mark T. Ziolo, PhD Graduate Program in Biophysics ABSTRACT Cardiovascular disease (CVD) is a major cause of mortality and morbidity worldwide. CVD accounts for more deaths than all forms of cancer in the United States. Hypertension, Heart Failure and Atrial Fibrillation are the most common diagnosis, hospitalization cause and the sustained cardiac arrhythmia respectively in the US. Sudden cardiac death is the one of the most common causes of cardiovascular mortality after myocardial infarction, and a common cause of death in heart failure patients. This has been attributed to the development of ventricular tachyarrhythmias. In addition, most forms of acquired CVD have been shown to produce electrophysiological changes due to very close interactions between structure, signaling pathways and ion channels. Due to the increased public heath burden caused by CVD, a high impetus has been placed on identifying novel therapeutic targets via translational research. Identification of novel therapeutic targets to treat heart failure and sudden death is underway and is still in a very nascent stage. In addition, ion channel blockers, more specifically “atrial-specific” ion channel blockers have proposed to be a major therapeutic target to treat atrial fibrillation without the risk of ventricular pro- arrhythmia.
    [Show full text]
  • The Benefits of Marine Omega-3S for Preventing Arrhythmias
    Open access Editorial Open Heart: first published as 10.1136/openhrt-2018-000904 on 4 February 2020. Downloaded from The benefits of marine omega- 3s for preventing arrhythmias James J DiNicolantonio, James OKeefe To cite: DiNicolantonio JJ, MARINE OMEGA-3S FOR THE PREVENTION OF polyunsaturated fatty acids (PUFAs) can also OKeefe J. The benefits of marine ARRHYTHMIAS be liberated from lipoproteins via lipoprotein omega- 3s for preventing and hepatic lipase and picked up by albumin arrhythmias. Open Heart Omega- 3s have been theorised to increase 2020;7:e000904. doi:10.1136/ membrane fluidity by reducing compression via fatty acid- binding sites. The omega- 3s are openhrt-2018-000904 of the acyl chains of membrane phospholipid then carried by albumin to the heart, brain fatty acids, which can lead to a reduction in and other tissues for entrance into membrane 4 Received 17 July 2018 the ‘spring- like’ tension on membrane ion phospholipids and stored as triglycerides. Revised 29 September 2018 channels. This spring-like tension can reduce However, it is the liberated ‘free- fatty acid’ Accepted 12 October 2018 the ability of ions to freely move in and out form of omega-3s that are thought to produce of the ion channel and hence reduce its the antiarrhythmic properties. This free conductance. This is known as the ‘Andersen form of omega-3 can be mobilised from the membrane spring- like tension hypothesis’ plasma phospholipid during states of stress and is just one way marine omega- 3s may (severe exertion, sympathetic discharge) via prevent arrhythmias.1 This theory states that phospholipases.5 6 If consumed on a regular the phospholipid cell membrane curves near basis, omega- 3s will be adequately stored the ion protein channel in order for the in the heart waiting to be released in order hydrophobic domains of the cell membrane to protect against fatal arrhythmias.
    [Show full text]
  • Effect of Omega-3 Fatty Acids on Ventricular Action Potentials in a Canine Model of Sudden Cardiac Death
    Effect of omega-3 fatty acids on ventricular action potentials in a canine model of sudden cardiac death THESIS Presented in Partial Fulfillment of the Requirements for the Degree Master of Science in the Graduate School of The Ohio State University By Sarmistha Mazumder Graduate Program in Pharmacy The Ohio State University 2010 Master's Examination Committee: Cynthia Carnes, PharmD, PhD, Advisor Terry S. Elton, PhD George E. Billman, PhD Copyright by Sarmistha Mazumder 2010 Abstract Background : Sudden cardiac death (SCD) is the most common cause of death in the United States and in most developed countries, accounting for ~ 50% of total mortality. The most common underlying cause of SCD is “ventricular fibrillation” (VF). Several clinical trials have reported conflicting results on the benefits of omega-3 fatty acids for the prevention of lethal ventricular arrhythmias following infarction. The explanation for these inconsistent results remains to be determined. Methods : Dogs with healed left ventricular anterior wall myocardial infarctions (MI, 3-4 weeks post- MI, n = 76) were subjected to an exercise and ischemia test to stratify animals by arrhythmia risk as VF susceptible, VF + (n = 46) and VF resistant, VF - (n = 30). The animals were then assigned to omega-3 fatty acid ethyl esters (1-4 grams/day, n = 45) or corn-oil treatment (placebo, n = 31) for 3 months. Following treatment, arrhythmia inducibility was re-evaluated with the exercise and ischemia test. The left ventricular myocytes were isolated one week following the exercise plus ischemia test. Five age matched dogs served as controls (non-infarcted). Action potentials were recorded by perforated whole cell patch clamp studies (T= 36 ± 0.5ºC) to measure the resting membrane potentials (RMP) and the action potential duration at 90% repolarization (APD 90 ).
    [Show full text]
  • Letter to President Obama Vivisection Marlene Phelan March 17, 2011
    letter to president obama vivisection marlene phelan March 17, 2011 1 March 17th, 2011 The White House 1600 Pennsylvania Ave. NW Washington, D.C. 20500 Dear Mr. President; I would like to speak out for 115 million individuals a year whose voices will never be heard. I would like to speak of their outrageous, heartbreaking suffering. “Sanitized Sadism” is what it has been called by one human. This legalized torture is hidden in buildings without windows. It takes place in basements, cellars, and underground rooms. George Bernard Shaw once said, “There are hundreds of paths to scientific knowledge. The cruel ones can teach us only what we ought not to know.” This sanitized sadism costs the United States taxpayers over 18 billion dollars annually. This tragic waste of life is represented here in print, photos and DVD’s of numerous undercover investigations of laboratories in the United States. These animals are voiceless victims of a devious atrocity that is called vivisection. Vivisection is a method of “science”, which was labeled by Dr. Frederic Mayo, founder of the Mayo clinic, as “Evil.” “My own conviction is that the study of human physiology by way of experiments on animals is the most grotesque and fantastic 2 error ever committed in the whole range of human intellectual ability.” (Dr. G.F. Walker in “Medical World” Dec. 8, 1933). The victims of these scientific atrocities have faces. I would like to introduce you to one rare survivor known formerly only as “CH 411”. (“CH 411”,Tom, 1965-2009) 3 “CH 411” was the way he was referred to by laboratory workers that kept him in a cage for 30 years.
    [Show full text]
  • Future Physiologists Early Career Special Issue Experimental Models in Physiology 27 - 29 June 2018 | University of Exeter, UK
    PN Issue 109 / Winter 2017 Physiology News Future physiologists Early career special issue Experimental models in physiology 27 - 29 June 2018 | University of Exeter, UK The Mighty Mouse and the might of other models Why is the mouse not so mighty? Complementary models Pathophysiological models: Cells to complex systems Insights from animal models of human disease Towards human models Future directions: Opportunities and challenges www.physoc.org/models Physiology News Scientific Editor Roger Thomas We welcome feedback on our membership magazine, or letters and suggestions for (University of Cambridge) articles for publication, including book reviews, from our Members. Managing Editor Please email Julia Turan at [email protected] Julia Turan Editorial Board Physiology News is one of the benefits of membership, along with reduced registration rates Karen Doyle for our high-profile events, free online access to our leading journals,The Journal of Physiology, (NUI Galway) Experimental Physiology and Physiological Reports, and travel grants to attend scientific Rachel McCormick meetings. Membership offers you access to the largest network of physiologists in Europe. (University of Liverpool) Keith Siew Join now to support your career in physiology: (University of Cambridge) Visit www.physoc.org/membership or call 0207 269 5721 Austin Elliott (University of Manchester) Mark Dallas (University of Reading) Membership Fees for 2017 FEES Fiona Hatch Fellow £120 (Cello Health Communications iScience, Member £90 Medical writer) [email protected] Retired Member – Affiliate £40 www.physoc.org Associate £30 Undergraduate – @ThePhySoc /physoc Opinions expressed in articles and letters submitted by, or commissioned from, Members, Affiliates or outside bodies are not necessarily those of The Physiological Society.
    [Show full text]
  • DAVID C. RANDALL DATE of BIRTH April 23, L945 DEGREES HELD BA
    DAVID C. RANDALL DATE OF BIRTH April 23, l945 DEGREES HELD B.A. (scl) physics, chemistry Taylor University, l967 Ph.D. physiology University of Washington, l972 POSITIONS HELD 2007 - present Donald T. Frazier Professor, Department of Physiology and Biophysics, College of Medicine, University of Kentucky 1985 - present Professor, Department of Physiology and Biophysics, College of Medicine, University of Kentucky 1978 - 1985 Associate Professor, Department of Physiology and Biophysics, College of Medicine, University of Kentucky 1981 - 1984 Director of Graduate Studies, Department of Physiology and Biophysics, University of Kentucky 1981 Visiting Associate Professor, Department of Neurobiology and Behavior, State University of New York at Stony Brook 1979 - 2014 Part-time Instructor, Asbury University, Wilmore, KY 1975 - 1978 Assistant Professor, Department of Physiology & Biophysics, College of Medicine, University of Kentucky 1972 - 1975 Assistant Professor, Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine JOINT APPOINTMENTS 1987 - Present Professor, Graduate Center for Biomedical Engineering, University of Kentucky (Executive Committee, 1990 - 1992) 2004 - Present Associate Faculty, University of Kentucky Spinal Cord and Brain Injury Research Center MEMBERSHIP ON PUBLIC ADVISORY GROUPS American Heart Association, Kentucky Affiliate Research Peer Review Committee (1980 - 1990; chair, 1985 – 1987) Resource Allocation Committee, (member, 1986 - 1992; chair,
    [Show full text]
  • Physiologynews
    PHYSIOLOGYNEWS winter 2006 | number 65 Meetings Bristol Brazil Heidelberg International Workshop, Kiev Also featuring A century of research in sugar transport A summer in the life of a retiring physiologist Did evolution go the wrong path for the human lung? Acute pain Legs pay out for cost of breathing! Long and tortuous goodbye to Stud Muffin No 1 A publication of The Physiological Society IMAGES OF BRAZIL JOINT INTERNATIONAL MEETING WITH THE BRAZILIAN PHYSIOLOGICAL SOCIETY Ribeirão Preto, Brazil 27-30 August 2006 For more images of Brazil, including flora and fauna, see the inside back cover (photos by Prem Kumar) PHYSIOLOGYNEWS Editorial 3 Meetings Bristol Focused Meeting Johannes Reul, Astrid Linthorst, 4 The Society’s dog. ‘Rudolf Magnus gave Stafford Lightman me to Charles Sherrington, who gave me Heidelberg Focused Meeting Joseph Bruton 5 to Henry Dale, who gave me to The Images of Brazil inside front and back covers Physiological Society in October 1942’ Living history The surface energy of water from 1908 Wilfred Widdas 7 A summer in the life of ... Published quarterly by The Physiological Society An (endless?) summer in the life of a retiring physiologist 11 Contributions and Queries David Miller Executive Editor Features Linda Rimmer The Physiological Society Publications Office What structures bear the tension and store energy in lengthening 13 P O Box 502 muscle? Gavin Pinniger, K W Ranatunga, Gerald Offer Cambridge CB1 0AL Acidification protects skeletal muscle volume during anaerobic 15 UK exercise Juliet Usher-Smith,
    [Show full text]