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ContentsWELCOME MESSAGE 6
PRE CONGRESS COURSES 11
SCIENTIFIC PROGRAM 23
HPP MORNING SESSIONS 63
INDUSTRY WORKSHOP PROGRAMS 83
POSTERS 97
GENERAL INFORMATION 275
EXHIBITION FLOOR PLAN 282
COMPANY PROFILES 285
AUTHORS INDEX 298
5 WELCOME MESSAGE
Dear colleagues,
It is our great pleasure to welcome you all to the 13th World Congress of the Human Proteome Organization , the 7th EuPA annual conference and the 6th Spanish Proteomics Society Congress that are celebrated conjointly in Madrid.
Despite the fast advances experienced over the last few years, Proteomics is still at its youthfulness. It is a discipline with a tremendous future that offers all kinds of opportunities to analyze biological systems with unprecedented efficacy to generate new concepts in biology, identify new diagnostic and therapeutic targets and study drug effects in cell biology.
The challenge of defining and understanding proteomes in the context of cell biology is huge and requires a multidisciplinary effort to ensure innovative technical developments, the generation of biological information as well as the integration and interpretation tools to transform the information into biological knowledge. We sincerely hope to have been able to create an ideal environment where international experts can discuss all these aspects generating new ideas and establishing productive scientific interactions.
We wish you a pleasant and productive stay in Madrid, including its art galleries offer, which will amaze you and since life is not only science, do not forget to spare some time visiting Madrid, including its art galleries offer which will amaze you. Be careful with the small and charming bars of the old town, they are pretty addictive...
We are waiting for you in Madrid
Fernando J. Corrales Juan Pablo Albar Juan Calvete Concha Gil
Chairs of 13th HUPO World Congress
6 COMMITEES
CONGRESS CO-CHAIRS
Concha Gil Juan Pablo Albar Juanjo Calvete Fernando J. Corrales
ORGANIZING COMMITTEE
Fernando Vivanco Manuel Sánchez del Pino Ignacio Casal Montserrat Carrascal Jesús Vázquez Eliandre de Oliveira Lucía Monteoliva Ángel García Jesús Jorrín José M. Mato Juan A. Vizcaino
CHAIRS OF HUPO EDUCATION DAY, HUPO CLINICAL DAY, EUPA DAY, HUPO & EUPA AWARDS AND HUPO & EUPA INITIATIVES
CLINICAL DAY CHAIRS: Jennifer Van Eyk, Ignacio Casal
HUPO & EUPA AWARDS CHAIRS: Luca Bini, Mark Baker
HUPO & EUPA INITIATIVES CHAIRS: Gilbert Omenn, Garry Corthals, Bill Hancock
PRECONGRESS COURSE AND EDUCATIONAL DAY CHAIRS: Peter James, Montserrat Carrascal, Thierry Rabilloud
7 Human Proteome Organisation
WHAT IS HUPO?
The Human Proteome Organisation (HUPO) is an international scientific organization representing and promoting proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training.
HUPO EXECUTIVE COMMITTEE
President Pierre Legrain (2013-2014) Past President Catherine Costello (2013-2014) Vice-President William Hancock (2013-2014) Treasurer Bruno Domon (2014-2016) Secretary General Maxey C.M. Chung (2013-2014) President-Elect Mark Baker (2014) Member-at-Large Gilbert S. Omenn (2013-2014) Member-at-Large Michael Snyder (2014-2015)
HUPO COUNCIL (BOARD OF DIRECTORS)
The HUPO Council is the decision-making body. The Council is elected by the HUPO members.
8 European Proteomics Association (EuPA)
The European Proteomics Association (EuPA) is the federation of European national proteomics societies. It has been established to coordinate and integrate national initiatives within the proteomics field. The main objectives are to strengthen and promote fundamental research and applications, as well as education and training in all areas of proteomics throughout Europe. EuPA is a non-profit organization.
CURRENT EXECUTIVE COMMITTEE
President: Gyorgy Marko-Varga Vice-President: Jean-Charles Sanchez Conference & Communication committee: Luca Bini Education committee: Peter James Eu-HUPO committee: Emøke Bendixen Funding committee: Peter Verhaert New Developments Committee: Garry Corthals
Current EuPA country members are:
Austria, Belgium, Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Italy, Luxembourg, Netherlands, Norway, Poland, Portugal, Russia, Spain, Sweden, Switzerland, Turkey and United Kingdom
9 Spanish Proteomics Society (SEProt)
SEProt was founded in 2004 and it currently has about 200 members .The main objective of SEProt is to promote the development of Proteomics in Spain. This is to be done by encouraging scientific and technical research in the field of Proteomics, by promoting training, learning and formation in this field, and by sponsoring and facilitating the organization and/or participation of their members in national or international activities, courses, workshops and meetings and any kind of cooperation and interchange with other societies.
President: Fernando J. Corrales CIMA-Universidad de Navarra, Pamplona
Vice-president: Fernando Vivanco Universidad Complutense, Fundación Jiménez Diaz, Madrid
Secretary: Manuel M. Sánchez del Pino Universidad de Valencia, Valencia
Treasurer: Eliandre de Oliveira Plataforma de Proteómica, Parc Cientific de Barcelona
Vocals: Ignacio Casal Juanjo Calvete CIB, CSIC, Madrid IBV-CSIC, Valencia
Concha Gil Ángel García Universidad Complutense de Madrid Universidad de Santiago de Compostela
Jesús Jorrín Lucía Monteoliva Universidad de Córdoba Universidad Complutense de Madrid
Jesús Vázquez Montserrat Carrascal CBM SO-UAM-CSIC, Madrid IIBB-CSIC-IDIBAPS, Barcelona
Proteored
ProteoRed-ISCIII is a technological platform integrating 25 proteomics laboratories distributed all over Spain. The main objective of ProteoRed-ISCIII consortium is to coordinate and integrate activities of the Spanish proteomic facilities and services in a common network with a nodal structure, to support the whole development of proteomic research in our country.
10 List of Volunteers
Name Last Name Name Last Name
Adan Alpízar Morúa Luis Felipe Clemente Velarde Ahinara Amador García Mª Carmen Mena Valverde Aida Pitarch Velasco Mª Luisa Hernáez Sánchez Alberto Peláez García Manuel Lombardia Uria Alberto Paradela Elizalde María del Mar González Garcés Ana Martinez del Val María Dolores Segura Buitrago Ana Gil de Bona Maria Isabel Mora Orellano Antonio Ramos Miguel Marcilla Goldaracena Beatriz Escudero Paniagua Miguel Ángel López García Carmen González Tejedo Noemi Bujan Catarina Oliveira Vaz Nuria Ibarz Ferrer Dolores Gutiérrez Blázquez Perceval Vellosillo Elvira Marín Pilar Ximénez de Embún Cadarso Emilie Bigaud Roi Villar-Vázquez Gema Bravo Sanz Rosana Navajas Morillas Gonzalo Martínez Martínez Sergio Ciordia Higuera Inés Zapico Megido Severine Gharbi Inmaculada Cosano Maya Víctor Fanjul Hevia J. Alberto Medina Auñón Virginia Pavon Mañani Jose Antonio Reales Calderón Vital Vialas Fernandez Lucía Monteoliva Díaz PRE CONGRESS COURSES
11 PROTEOMICS INFORMATICS WITH THE TRANS-PROTEOMIC PIPELINE (TPP)
Date
29th September - 2nd October 2014
Course Venue
Edificio nuevo, Facultad de Farmacia UCM Room: Aula de informática Address: Plaza Ramón y Cajal S/N. 28040 Madrid Metro Station: Ciudad Universitaria (Line 6).
Agenda
• Data Conversion • TPP installation • Database searching • PeptideProphet • iProphet • PTMProphet • ProteinProphet • Quantitation software • Spectral library searching • TPP on Amazon Web Services • PeptideAtlas • SRMAtlas
Speakers
• Luis Mendoza • David Shteynberg • Eric Deutsch • Ulrike Kusebauch
Fees
• Students: 150 EUR • Academic: 250 EUR • Industry: 500 EUR
Pre-registration
http://tools.proteomecenter.org/course/
12 PROTEOMICS INFORMATICS: MASCOT, MAXQUANT, PROGENESIS AND SKYLINE
Organisers
EuPA and HUPO Education Committees with Lund University - Peter James
Course dates: October 03 – 04, 2014
Two days, Friday 3rd Saturday 4th October before the HUPO congress. There are four half- day courses covering modern bioinformatics for Proteomics. In accordance with the HUPO/ EuPA guidelines, we aim to:
• Provide a theoretical basis for understanding the software used • Provide practical instruction in laboratory techniques
Course Venue
Edificio nuevo, Facultad de Farmacia UCM Room: Aula de informática Address: Plaza Ramón y Cajal S/N. 28040 Madrid Metro Station: Ciudad Universitaria (Line 6).
13 COURSE OUTLINE
Friday 3rd October GROUP 1 GROUP 2 Jurgen Cox John Cottrell 13:00 - 16:30h MAXQUANT MASCOT
16:30 - 17:00h Coffee break
Mike MacCoss Martin Wells 17:00 - 20:30h SKYLINE SRM PROGENESIS
Saturday 4th October
John Cottrell Jurgen Cox 9:30 - 13:00h MASCOT MAXQUANT
13:00 - 14:30h Lunch
Martin Wells Mike MacCoss 14:30 - 18:00h PROGENESIS SKYLINE SRM
* Lunch and coffee will be provided.
14 Please follow the instructions below:
MASCOT Course. John Cottrell Please bookmark the following page: http://www.ms-ms.com/exercises/exercises.html
PROGENESIS Course. Martin Wells Please download and install the Progenesis QI software from here http://www.nonlinear.com/progenesis/qi-for-proteomics/download And also the DDA tutorial dataset and user guide http://www.nonlinear.com/progenesis/qi-for-proteomics/download
MAXQUANT Course. Juergen Cox Please download and install the MaxQuant software from here http://www.maxquant.org/downloads.htm
SKYLINE SRM Course. Mike MacCoss Please download and install the Skyline software from here https://skyline.gs.washington.edu/labkey/project/home/software/Skyline/begin.view
How to register
Use the registration form of the congress for attending to this course.
Please note you have the options to attend only to the “Pre-Congress course” or both “Pre-Congress + Congress”.
15 EDUCATIONAL DAY PROTEOMICS: BASICS AND APPLICATIONS
Date
Sunday 5th October 2014 09:00 - 17:30 h. - Room: H
Organizing team
Montserrat Carrascal, Peter James and Thierry Rabilloud.
Agenda
09:00 - 10:00 h Introduction to proteomics. Basic concepts. Thierry Rabilloud (Institut de Recherches en Technoloqies et Sciences pour le Vivant-Grenoble)
10:00 - 10:50 h MS/MS and shotgun proteomics Mike MacCoss (University of Washington)
10:50 - 11:10h Coffee break
11:10 - 12:00 h Quantitative mass spectrometry Albert Heck (Netherlands Proteomics Centre, Utrecht)
12:00 - 12:50 h Postraslational Modifications Martin Larsen (University of Southern Denmark, Denmarck)
12:50 - 13:40 h Antibody and protein arrays. Matthias Uhlen (KTH Royal Institute of Technology, Sweden)
13:40 - 15:00 h Lunch time
15:00 - 16:00 h Manual MS/MS Interpretation of CID data. Peter James (Department of Immunotechnology, Lund University)
16:00 - 17:00 h Manual MS/MS Interpretation of ETD data Donald Hunt (Department of Chemistry, University of Virginia)
17:00 - 17:30 h Concluding remarks
16 CLINICAL DAY
Date
Sunday 5th October 2014 09:00 - 17:30 h. - Room: E
Organizing team
Jennifer Van Eyk, Gustavo Salem, Oliver Poetz, Jochen Schwenk, Charles Pineau and Ignacio Casal
From discovery to clinical impact: the road to translation and commercialization
Background: It is the right time to move proteomics beyond the research stage, and acknowledge that there are now protein biomarkers that can be or are used in clinical diagnostics. Efforts to commercialize protein biomarkers are currently at the stage of addressing the important new challenges of demonstrating clinical utility to physicians and establishing reimbursement plans with payers.
The translation from discovery to the clinic requires impactful clinician applications, but also requires research and development so that understanding of the disease and clinical framework can be established. The initial successes include diagnostic tests to improve patient outcomes in cancer, heart disease, metabolic disorders, and neurological disease.
Equally important are the technology platforms that allow for seamless quantification in CLIA and clinical chemistry laboratories, and potentially point-of-care. Important developments in the areas of mass spectrometry, multiplexing, and automation are underway and are improving the adoption of protein-based diagnostics.
09:30 - 09:40 h Opening remarks: The winding path forward from discovery to patient impact
Speakers: Jennifer Van Eyk, Advanced Clinical Biosystems Institute, Cedars Sinai Medical Center, Gustavo Salem, President and CEO, SISCAPA Assay Technologies, Charles Pineau, Research Director Inserm IRSET, Director Proteomics Core Facility Biogenouest, France
17 Session 1: The reality of biomarkers and clinical utility: making it happen
Goal: The “clinical” in clinical chemistry: evaluating cohorts, biobanking, discovery, and protein quantification of new biomarkers to aid their acceptance by physicians. What are the medical needs that are not been serviced currently which proteomics are or can address? What are the needed technologies, approach and concepts to allow proteomics to meet its potential.
Moderator: Charles Pineau, Research Director Inserm IRSET, Director Proteomics Core Facility Biogenouest, France
09:40 - 10:15 h Clinical Chemistry lab meets proteomics and new quantitative assays
Keynote: The journey to launching the Xpresys Lung test: a novel protein biomarker panel for nodule classification Paul Kearney Co-Founder, President and CSO, Integrated Diagnostics, Seattle, USA
Session 2: Due diligence: Beyond discovery and establishing intended use.
Goal: To provide the big view on the transition between discovery and a commercial product intended for patient care. Considerations from entrepreneurial verses established diagnostic company perspective. What is needed from academics to increase potential of successful hand off for commercialization and clinical utility?.
Moderator: Ina Schuppe-Koistrum, Scientific coordinator of the SAFET project and Director Biochemical Biomarkers, Astra Zeneca
10:15 - 10:30 h Speaker 1: Donna Edmonds President and CEO, Virginia Biosciences Commercialization Center 10:30 - 10:45 h Speaker 2: Gustavo Salem President and CEO, SISCAPA Assay Technologies, Inc. (Formerly VP and General Manager, Biological Systems Division – Agilent Technologies)
10:45 - 11:00 h Questions and debate: Discussion around commercialization and interaction with academics Lead by Ina Schuppe-Koistinen. Scientific coordinator of the SAFET project and Director Biochemical Biomarkers, Astra Zeneca
11:00 - 11:20 h BREAK
18 Session 3: Success in the clinic: a long road from discovery proteomics
Goal: To provide overview of the diverse commercial successes in proteomics and biomarker diagnostics.
Moderator: Jochen M Schwenk, SciLifeLab and KTH Royal Institute of Technology, Sweden (part 1 and 2)
11:20 - 11:50 h Speaker 1: From discovery to building a FDA-Trial: Circulating brain injury biomarkers for pediatric and adult acute clinical assessment. Allen Everett, Johns Hopkins University, Baltimore, USA 11:50 - 12:20 h Speaker 1: The value of longitudinal testing for continuous and personalized assessment of wellness and disease: at-home DBS sampling for SISCAPA multiplexed protein assays. Selena Larkin, SISCAPA Assay Technologies, Inc., USA)
12:20 - 12:35 h Personal viewpoint: Translational route through biobanks - a key component towards clinical use?
Goal: To summarize what are the major challenges related to biobanking and cohort collections that must be considered and overcome for bridging into a next era of biomarkers with enhance clinical impact and utility
Speaker: Jochen Schwenk, SciLifeLab and KTH Royal Institute of Technology, Sweden
12:35 - 13:35 h LUNCH
13:35 - 14:10 h The reality of biomarkers and clinical utility: making it happen
Moderator: Katrin Marcus, University Bochum, Germany
Keynote: Analytical development and validation of a novel biomarker panel for colon polyp detection”, Bruce Wilcox, Director of Instrumentation and Lab Operations, Applied Proteomics, Inc.
Session 4: The technical hurdle: What are the next enabling technologies?
Goal: Next steps in generating proteomic data for clinical applications: pushing the edge of technology.
Moderator: Christoph H Borchers, University of Victoria, Victoria, Canada
19 14:10 - 14:35 h Speaker 1: Mass spectrometry development is only the beginning Jennifer Van Eyk, Director, Advanced Clinical BioSystems Research Inssitue, Cedar Sinai Medical College, Los Angeles, USA 14:35 - 15:00 h Speaker 1: Evolution and next generation of immune/aptimer assays Oliver Poetz, Head Protein Analytics, University of Tuebingen, Germany
15:15 - 15:15 h Personal viewpoint: are we on the right road?
Goal: To summarize what are the key challenges that need to be overcome in bringing next era of protein-based quantitation to enhance clinical impact
Speaker: Christoph H Borchers, University of Victoria, Victoria, Canada
15:15 - 15:20 h BREAK
Session 5: Discussion panel and question period
Moderator: Jennifer Van Eyk
Discussants: Gustavo Salem: President and CEO, SISCAPA Assay Technologies Paul Kearney: Co-Founder, President and CSO, Integrated Diagnostics Inc. Bruce Wilcox: Director of Instrumentation and Lab Operations, Applied Proteomics Inc. Ralph Schiess: Proteomedix Donna Edmonds: President and CEO, ImmunArray/Veracis Inc.
A. Given that many clinical assays today are still based on ELISA type of assays, how can MS or other proteomic technology platforms add / supplement / replace current systems in use? What does it take to get an MS-based protein assay into the market? B. What are the key lessons one would you take to the NEXT development-stage protein panel? C. What do the regulators think about these new, LDT protein tests? D. Is there a place for integration of genomics and other ‘Omic data in a clinical assay? E. What is missing when communicating proteomics and its opportunities with intended users? F. What kind of new career opportunities are being created in these new companies? 15:20 - 17:30 h Speaker 1: Personal viewpoint: Are we on the right road? To summarize and discuss what are the key technical challenges in bring- ing the next era of protein-based quantitation to enhance clinical impact. Speakers: Jennifer Van Eyk, Charles Pineau and Gustavo Salem 20 3D IMAGING MASS SPECTROMETRY WORKSHOP
Imaging Mass Spectrometry is an exciting, rapidly developing, and promising field of mass spectrometry and –omics sciences. 3D imaging mass spectrometry represents a new frontier in this field. The aim of this workshop is to highlight the newest achievements in this advanced field, bring scientists contributing to this field with methodological, computational, and biomedical developments, and discuss where the field can go in the future.
The workshop is organizes in the framework of the 3D-MASSOMICS project (http://3d-massomics.eu)
Date & Place
Sunday 5th October 2014 HUPO’14 main place (Centro de Convenciones Norte), Madrid, Spain; room I
Registration
The workshop will be free of charge, sponsored by the EU FP7 3D-MASSOMICS project and Bruker Daltonics.
However, in order for us to estimate the number of participants, please register online, separately from the HUPO Congress by using this link: https://docs.google.com/forms/d/1X0I-PL7wWSM_iWZnkyNYBcEfOfNMID6R5qVO919gZc0/edit
Workshop speakers
• Ron Heeren, FOM-AMOLF, NL • Livia Eberlin, Stanford, US • Per Andren, Uppsala University, SE • Amanda Hummon, Notre Dame University, US • John S. Fletcher, University of Gothenburg, SE • Jeramie Watrous, University of California San Diego, US • Ferdinand von Eggeling, Jena University Hospital, DE • Pierre Chaurand, Université de Montréal, CA • Olga Vitek, Northeastern University, US
Submissions
We do not plan to accept submissions for this workshop. However, if you would like to present exciting results on 3D imaging mass spectrometry either as a talk or as a poster, please contact Theodore Alexandrov ([email protected]) over email.
21 Workshop organizers
• Fernando Vivanco Martínez, Fundación Jiménez Díaz, ES • Charles Pineau, University of Rennes 1 / INSERM, FR • Dennis Trede, SCiLS GmbH, DE • Theodore Alexandrov, University of Bremen / University of California San Diego / SCiLS, DE/US
For more information, please email us at: [email protected], [email protected], [email protected], [email protected]
PROTEOMEANALYZER – WORKSHOP SUNDAY
09:00 - 11:30 h Room G
09:00h Introduction
09:05h Viewpoints of End-user and HPP/BD Users’ 09:30h Proteome Analyzer Survey – Results
09:45h Viewpoint of Manufacturers
10:10h Discussion ProteomeAnalyzer I 10:50h Discussion ProteomeAnalyzer II
11:30h Wrap up
Everyone is invited to complete this survey on the ProteomeAnalyzer project: https://www.surveymonkey.com/s/ProteomeAnalyzer2014
22 SCIENTIFIC PROGRAM
23 SCIENTIFIC PROGRAM Sunday October 5th
24 Room A+B+C Room D Room E Room F Room G Room H Room I Room K
08:30 Opening Secretariat - Documentation Delivery
09:00 - 10:00 Proteome Analyzer 10:00 - 11:30
11:30 - 14:00 Human Proteome EuPA Council HUPO Educational 3D 14:00 - 16:00 Project Clinical day Council day Massomics
16:00 - 17:00
17:00 - 17:15
17:15 - 17:30
17:30 - 18:00
Opening 18:00 - 20:00 Ceremony
20:00 - 21:30 Opening Reception (Exhibition Hall) 25 18:00 - 20:00 Opening Ceremony: In Memory of Juan Pablo Albar
Chairs C. Gil F. J. Corrales J. J. Calvete
18:15 - 19:00 MULTIPROTEIN ASSEMBLIES OF THE HUMAN PROTEOME: IMPLICATIONS FOR CELL SIGNALLING AND DRUG DISCOVERY
Keynote Tom L. Blundell Speaker University of Cambridge, United Kingdom
19:00 - 19:45 A GLOBAL AND GENOME-WIDE HUMAN PROTEIN ATLAS BASED ON INTEGRATION OF OMICS APPROACHES
Keynote Mathias Uhlen Speaker KTH Royal Institute of Technology, Stockholm, Sweden
20:00 - 21:30
Exhibit Hall Welcome Reception
26 SCIENTIFIC PROGRAM Monday October 6th
28 Room A Room B Room C Room D Room E Room F Room G Room H Room I HPP Morning Sessions
08:00 - 09:20 Extreme Infectious HPPP (Plasma) C-HPP I Cancer I iMOP Liver EyeOME Conditions Diseases
09:30 - 10:15 Plenary Lecture
10:20 - 11:00 Coffee Break - Exhibition Hall
Regulation of Microvesicle Cancer 11:00 - 12:50 cellular pathways. Proteogenomics and organelle Proteomics I Role of PTMs proteomics Eupa young investigator Lunch Lunch Session Symposium Symposium 13:00 - 14:15 Bruker Daltonik Waters GmbH Corporation
14:15 - 15:45 Poster Session
16:00 - 16:45 Plenary Lecture
Proteomics of New trends in obesity and related Non-human and HUPO young 16:45 - 18:35 biomarker dis- Phosphoproteomics metabolic liver food investigator covery disorders. proteomics Session Metabolomics
HUPO General 18:35 - 19:05 Assembly
19:05 - 20:00 Informal Mixer with Exhibits-Posters 29 09:30 - 10:15
Room A Plenary Lecture
Chair J. Muñoz
09:30 - 10:15 PROTEOMICS BEYOND TRYPSIN
Keynote Albert Heck Speaker Utrecht University, The Netherlands
10:20 - 11:00 Coffee Break - Exhibition Hall
11:00 - 12:50
Room A Cancer Proteomics I
Chair H. Rodriguez I. Casal
11:00 - 11:25 POWER IN COMBINING GENOMICS AND PROTEOMICS (CPTAC’s COLORECTAL CANCER STUDY: NEW MOLECULAR FEATURES DISCOVERED)
Keynote Henry Rodriguez Speaker National Cancer Institute, Washington, USA
11:25 - 11:50 MOLECULAR INSIGHTS IN COLON CANCER METASTASIS
Keynote Ignacio Casal Speaker Centro de Investigaciones Biológicas (CSIC), Madrid, Spain
11:50 - 12:05 OP001 - A QUANTITATIVE PROTEOMIC INVESTIGATION OF PAIRED COLORECTAL CANCER AND NORMAL TISSUE SAMPLES
Manveen Sethi Macquarie University, Sydney, Australian
12:05 - 12:20 OP002 - PROTEOMIC INVESTIGATION OF INTRA-TUMOR HETEROGENEITY
Tiannan Guo Institute of Molecular Systems Biology, ETH Zurich, Switzerland
12:20 - 12:35 OP003 - PROTEOMIC PATTERNS UNRAVEL A NEW LUMINAL A BREAST CANCER MOLECULAR SUBGROUP
Angelo Gámez-Pozo Hospital Universitario La Paz-IdiPAZ. Madrid, Spain
12:35 - 12:50 OP004 - A SYNTHETIC LETHAL INTERACTION BETWEEN APC/C AND TOPOISOMERASE POISONS UNCOVERED BY PROTEOMIC SCREENS
Fernando Garcia Spanish National Cancer Research Centre, Madrid, Spain 30 Room B Regulation of Cellular Pathways. Role of PTMs
Chair O. Jensen M.M. Sánchez del Pino
11:00 - 11:25 MODIFICATION-SPECIFIC PROTEOMICS: STRATEGIES FOR THE CHARACTERIZATION OF CO-EXISTING POST-TRANSLATIONAL MODIFICATIONS IN PROTEINS
Keynote Ole Jensen Speaker University of Southern Denmark, Odense, Denmark
11:25 - 11:50 INNOVATIVE METHODS AND NEW MASS SPECTROMETRY INSTRUMENTATION FOR THE CHARACTERIZATION OF PROTEIN AND PEPTIDE POST-TRANSLATIONAL MODIFICATIONS
Keynote Donald Hunt Speaker University of Virginia, Charlottesville,USA
11:50 - 12:05 OP005 - CONVERGENCE OF UBIQUITYLATION AND PHOSPHORYLATION SIGNALING IN RAPAMYCIN-TREATED YEAST CELLS
Vytautas Iesmantavicius University of Copenhagen, Denmark
12:05 - 12:20 OP006 - A NOVEL DATA-INDEPENDENT APPROACH ALLOWS AN EXTREMELY DETAILED STRUCTURAL MAP OF PROTEIN COMPONENTS OF MITOCHONDRIAL COMPLEXES AND SUPERCOMPLEXES
Enrique Calvo National Cardiovascular Research Centre ;Madrid, Spain
12:20 - 12:35 OP007 - CHAFRADIC - A NOVEL MULTIFUNCTIONAL TOOL FOR PTM-SPECIFIC PROTEOMICS
Rene P. Zahedi Leibniz–Institut Für Analytische Wissenschaften - ISAS, Dortmund, Germany
12:35 - 12:50 OP008 - PROTEOMIC ANALYSIS OF CELLULAR CHOLESTEROL REGULATION USING TARGETED MASS-SPECTROMETRY
Peter Blattmann Institute of Molecular Systems Biology (IMSB), Zurich, Switzerland
Room C Proteogenomics
Chairs V. Bafna J Armengaud
11:00 - 11:25 PROTEOGENOMICS FOR CANCER
Keynote Vineet Bafna Speaker University of California, San Diego, USA
31 11:25 - 11:50 PROTEOGENOMICS, THE SENSU STRICTO AND SENSU LATO PANORAMA!
Keynote Jean Armengaud Speaker French Institute of Environmental Biology and Biotechnology, Saint-Paul-les-Durance, France
11:50 - 12:05 OP009 - A NOVEL UNPRECEDENTEDLY COMPREHENSIVE PROTEIN IDENTIFICATION STRATEGY, MASS SPECTROMETRY AND RIBOSOME PROFILING: THE PERFECT MATCH.
Gerben Menschaert Ghent University, Belgium
12:05 - 12:20 OP010 - PERSONALISED PROTEOMICS BY MEANS OF INDIVIDUALISED PROTEIN MICROARRAYS
Jörg Hoheisel German Cancer Research Center (DKFZ), Heidelberg, Germany
12:20 - 12:35 OP011 - A FAST DECOY-FREE APPROACH FOR RELIABLE IDENTIFICATON OF PSMS
Giulia Gonnelli Ghent University, Belgium
12:35 - 12:50 OP012 - AN INTEGRATED PROTEOGENOMIC STRATEGY FOR GENOME ANNOTATION AND GLOBAL POST-TRANSLATIONAL MODIFICATIONS DISCOVERY IN THE MODEL CYANOBACTERIUM SYNECHOCOCCUS SP. STRAIN PCC 7002
Feng Ge Chinese Academy of Sciences, Wuhan, China
Room D Microvesicle and Organelle Proteomics
Chairs R.J Simpson F. Elortza
11:00 - 11:25 SIMULTANEOUS AND DYNAMIC PROTEIN SUB-CELLULAR LOCALIZATION BY MASS SPECTROMETRY
Keynote Kathryn S Lilley Speaker The Cambridge Centre for Proteomics, United Kingdom
11:25 - 11:50 PROTEIN AND RNA TYPING OF THREE EXTRACELLULAR VESICLE (EV) SUBTYPES RELEASED FROM THE HUMAN LIM1863 COLORECTAL CANCER (CRC) CELL LINE: AN OMICS ROADMAP TO DISCOVERY
Keynote Richard J.Simpson Speaker La Trobe University, Melbourne, Australia
11:50 - 12:05 OP013 - HEPATIC EXOSOMES IN METABOLISM AND DISEASE
Juan M Falcon-Perez CIC bioGUNE, Derio, Spain
32 12:05 - 12:20 OP014 - PROTEOME-WIDE PROFILING OF SERUM EXOSOMES FOR IDENTIFICATION OF SCIRRHOUS GASTRIC CANCER BIOMARKERS
Koji Ueda The University of Tokyo, Japan
12:20 - 12:35 OP015 - GLYCOPROTEINS ON THE SURFACE OF MDSC EXOSOMES
Catherine Fenselau University of Maryland, USA
12:35 - 12:50 OP016 - CLINICAL AND TECHNICAL POTENTIALS AND PROSPECTS OF THE EV ARRAY
Malene Jørgensen Aalborg University Hospital, Denmark
Room E EuPA young investigator Session
Chairs P. James D. Penque
11:00 - 11:22 OP017 - THREE DIMENSIONAL ANALYSES OF PTM PATTERNS IN LARGE SCALE PROTEOMIC DATA
Alistair Edwards University of Southern Denmark, Odense, Denmark
11:22 - 11:44 OP018 - DISCOVERING THE GLUTEN FINGERPRINT: A SMALL STEP TOWARDS THE QUANTIFICATION OF GLUTEN IN PROCESSED FOODS
Maria Jose Martinez Esteso Institute For Reference Materials And Measurements, Geel, Belgium
11:44 - 12:06 OP019 - CELL-CELL COMMUNICATION AND SIGNALING IN COLON CANCER
Maria Magdalena Koczorowska University of Freiburg, Germany
12:06 - 12:28 OP020 - PROGNOSTIC EVALUATION OF 15 AUTOANTIBODY-TYPE SPECIFIC COLORECTAL CANCER BIOMARKERS IDENTIFIED THROUGH PROTEIN MICROARRAYS
Roi Villar-Vázquez Centro De Investigaciones Biológicas (CSIC), Madrid, Spain
12:28 - 12:50 OP021 - TOP-DOWN VENOMICS - HIGH RESOLUTION MASS SPECTROMETRY AS A FAST AND ACCURATE TOOL FOR THE PROFILING OF SNAKE VENOMS
Daniel Petras Institut Für Chemie, Berlin, Germany
33 13:00 - 14:15 Lunch Seminars / Lunch Break
14:15 - 15:45
Poster Session
Odd-numbered poster boards present
16:00 - 16:45 Plenary Lecture
Chair J.M Mato
16:00 - 16:45 PRACTICE & PERSPECTIVE OF HUMAN PROTEOME PROJECT - A TRIP FROM WASHINGTON TO MADRID (2002-2014)
Keynote Fuchu He Speaker Beijing Proteome Research Center. China
16:45 - 18:35
Room A New Trends in Biomarker Discovery
Chair S. Hanash F. Canals
16:45 - 17:10 THE VALUE OF BIOBANK PATIENT SAMPLES IN PROTEIN EXPRESION STUDIES
Keynote Gyorgy Marko-Varga Speaker Lund university, Sweden
17:10 - 17:35 MINING THE CANCER PHENOME AS A SOURCE OF BIOMARKERS
Keynote Sam Hanash Speaker MD Anderson Cancer Center, Houston, USA
17:35 - 17:50 OP022 - EXCLUSION OF CEREBRAL LESIONS IN MILD TRAUMATIC BRAIN INJURY USING PLASMA NUCLEOSIDE DIPHOSPHATE KINASE A (NDKA)
Linnea Lagerstedt University of Geneve, Geneve, Switzerland
17:50 - 18:05 OP023 - BLOOD BASED PROTEOMIC AND GENOMIC BIOMARKERS FOR CARDIAC TRANSPLANTATION: FROM DISCOVERY TO CLINICAL IMPLEMENTATION
Robert McMaster University of British Columbia, Vancouver, Canada
34 18:05 - 18:20 OP024 - GERM CELL-SPECIFIC PROTEINS MEASURED IN SEMINAL PLASMA EMERGE AS MARKERS OF SPERMATOGENESIS AND MALE INFERTILITY
Andrei Drabovich University of Toronto, Canada 18:20 - 18:35 OP025 - DIAGNOSIS AND PREDICTION OF PROGRESSION OF CHRONIC KIDNEY DISEASE BY ASSESSMENT OF URINARY PEPTIDES
Adela Ramírez-Torres Mosaiques Diagnostics GmbH, Hannover, Germany
Room B Phosphoproteomics
Chairs P. Thibault J. Abian
16:45 - 17:20 THE DEVELOPMENT OF PHOSPHOPROTEOMICS – FROM TECHNOLOGIES TO APPLICATIONS
Keynote Martin Larsen Speaker University of Southern Denmark, Odense, Denmark
17:20 - 17:35 OP026 - PHOSPHOPROTEOMICS OF ADENOVIRUS TYPE 2 PROTEINS
Sara Bergström Lind Uppsala University, Sweden
17:35 - 17:50 OP027 - PHOSPHOPROTEOMIC PROFILING OF POST-NATAL HEART DEVELOPMENT UNRAVELS A NOVEL MITOCHONDRIAL PROTEIN TO BE ASSOCIATED WITH THE MINOS COMPLEX
Sriram Aravamudhan Max Planck Institute For Heart And Lung Research, Bad Nauheim, Germany
17:50 - 17:05 OP028 - QUANTITATIVE PHOSPHOPROTEOMICS ON A µG-SCALE - A STRAIGHTFORWARD AND HIGHLY SENSITIVE ERLIC-SCX/RP-LC-MS STRATEGY
Stefan Loroch Leibniz-Institut Für Analytische Wissenschaften – ISAS, Dortmund, Germany
17:05 - 18:20 OP029 - THE DNA DAMAGE-INDUCED PHOSPHOPROTEOME IS MODULATED BY INHIBITION OF THE RECEPTOR TYROSINE KINASE MET
Ariel Bensimon ETH Zürich, Switzerland
17:05 - 18:20 OP030 - DYNAMIC PHOSPHOPROTEOMICS ANALYSES OF COLON CANCER CELLS REVEAL DIFFERENTIAL REGULATION OF SIGNALING PATHWAYS UPON RAF INHIBITION
Pierre Thibault Universite De Montreal/IRIC, Canada
35 Room C Proteomics of Obesity and Related Metabolic Liver Disorders. Metabolomics
Chairs T. Nilsson F.J Corrales
16:45 - 17:10 NEW CELL BIOLOGY THROUGH THE STUDY OF HUMAN FATTY LIVER DISEASE
Keynote Tommy Nilsson Speaker McGill University and Genome Quebec Innovation Centre, Canada
17:10 - 17:35 METABOLOMICS ILLUMINATES THE PATHS TO NONALCOHOLIC FATTY LIVER DISEASE
Keynote Jose María Mato Speaker CIC BIOGUNE- CIBEREHD, Derio-Bizkaia, Spain
17:35 - 17:50 OP031 - OMICS IN NUTRITION AND ITS PERSPECTIVES FOR PEDIATRICS RESEARCH AND HEALTHCARE
Martin Kussmann Nestlé Institute of Health Sciences, Lausanne, Switzerland
17:50 - 18:05 OP032 - CHARACTERIZATION OF BLOOD PLASMA METABOLOME OF HEALTHY MEN BY MASS SPECTROMETRY APPROACH
Oxana Trifonova Institute of Biomedical Chemistry RAMS, Russia
18:05 - 18:20 OP033 - TOWARDS SPATIAL METABOLOMICS: DATABASE DRIVEN METABOLIC ANNOTATION FOR IMAGING MASS SPECTROMETRY
Theodore Alexandrov University of Bremen, Germany
18:20 - 18:35 OP034 - PLASMA PROFILING REVEALS NOVEL BIOMARKERS FOR DRUG-IN- DUCED LIVER INJURY IN HUMANS
Maria Mikus KTH-Royal Institute of Technology, Stockholm, Sweden
Room D Non-Human and Food Proteomics
Chairs W. Weckwerth J. Jorrín Novo
16:45 - 17:15 GREEN SYSTEMS BIOLOGY - LINKING GENOME-SCALE METABOLIC MODELLING AND OMICS DATA IN ECOLOGY, EVOLUTION AND DEVELOPMENT
Keynote Wolfram Weckwerth Speaker University of Vienna, Austria
36 17:15 - 17:30 OP035 - PLANT PROTEOMICS: ITS APPLICATION TO CLARIFICATION OF FLOODING TOLERANCE MECHANISM IN SOYBEAN
Setsuko Komatsu National Institute of Crop Science, Tsukuba, Japan
17:30 - 17:45 OP036 - MARINE PROTEOMICS: FINDING MECHANISMS OF ADAPTATION IN LARVAE OF RED SEA BARNACLE BALANUS AMPHITRITE
Kondethimmanahalli Chandramouli University of Science And Technology, Thuwal, Kingdom of Saudi Arabia
17:45 - 18:00 OP037 - SHOTGUN PROTEOMICS OF DOG CEREBROSPINAL FLUID
Mårten Sundberg Uppsala University, Sweden
18:00 - 18:10 OP038 - DEVELOPMENT OF AN ABSOLUTE AND MULTIPLEX MS-BASED QUANTIFICATION METHOD FOR E. COLI CARBON CENTRAL METABOLISM PROTEINS: A TOOL TO FEED DYNAMIC PREDICTIVE MODELS
Myriam Ferro CEA/Grenoble, France
18:10 - 18:20 OP039 - ONE HEALTH PROTEOMICS: MECHANISM OF BACTERIAL COMPETITION IN FOOD SAFETY OF DAIRY PRODUCTS
Paola Roncada Istituto Sperimentale Italiano L. Spallanzani, Milano, Italy
18:20 - 18:30 OP040 - PROTEOMICS WORKFLOWS AND PROTOCOLS FOR THE STUDY OF ORPHAN SPECIES
Christof Lenz Max Planck Institute For Biophysical Chemistry, Göttingen, Germany
18:30 - 18:35 CONCLUSIONS: HOW CAN NON-HUMAN PROTEOMICS CONTRIBUTE TO HUPO INITIATIVE?
Wolfram Weckwerth University of Vienna, Austria Jesus V. Jorrín Novo University of Cordoba, Spain
Room E HUPO young investigator Session
Chairs T. Rabilloud S. Srivastava
16:45 - 17:07 OP041 - PROTEOMIC ANALYSIS OF INFLAMMATORY BOWEL DISEASE BIOPSIES IDENTIFIES PROTEINS THAT SEGREGATE CROHN’S DISEASE FROM ULCERATIVE COLITIS IN PEDIATRIC PATIENTS
Amanda Starr University of Ottawa, Canada
37 17:07 - 17:38 OP042 - CALPAIN-DEPENDENT CLEAVAGE IN HIGHLY ACTIVATED PLATELETS REVEALED BY QUANTITATIVE N-TERMINAL CHAFRADIC: ALTERATIONS IN SCOTT SYNDROME
Fiorella A. Solari Leibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany
17:38 - 18:00 OP043 - CHEMICAL PROBES FOR STUDYING CELL-TO-CELL COMMUNICATION IN PATHOGENIC BACTERIA
Ysobel Baker University of Cambridge, United Kingdom
18:00 - 18:22 OP044 - PROTEOGENOMIC ANALYSIS OF AN ASIAN MALARIA VECTOR – ANOPHELES STEPHENSI
T. S. Keshava Prasad Institute of Bioinformatics, Bangalore, India
18:22 - 18:35 OP045 - UNRAVELING TRKA SIGNALING IN NEUROBLASTOMA USING A QUANTITATIVE MS-BASED APPROACH
Kristina B. Emdal The Novo Nordisk Foundation Center For Protein Research, Copenhagen, Denmark
18:35 - 19:05
Room B HUPO General Assembly
Chairs P. Legrain HUPO President
19:05 - 20:00 Informal Mixer with Exhibits-Posters
38 SCIENTIFIC PROGRAM Tuesday October 7th
40 Room A Room B Room C Room D Room E Room F Room G Room H Room I HPP Morning Sessions
Biobanking & 08:00 - 09:20 PSI/ Antibody Brain Pre-Analytical Diabetes Cancer II Glycoproteomics Stem Cells ProteomeXchange Proteomics Project Sample Assesment
09:30 - 10:15 Plenary Lecture
10:20 - 11:00 Coffee Break - Exhibition Hall
Integrative Immunobiology REDOX Cancer EuPA 11:00 - 12:50 proteomics and and cell proteomics and Proteomics II initiatives systems biology signalling mitochondrial biology
Lunch Lunch 13:00 - 14:15 Symposium Symposium ABSciex Thermo Fisher
14:15 - 15:45 Poster Session
16:00 - 16:45 Plenary Lecture
Glycoproteomics Inflammatory Proteomics of human Standardisation in EuPA 16:45 - 18:35 in biology and and rheumatic microbiome and proteomics:tribute to Company diseases diseases infectious diseases Juan Pablo Albar Club
Meeting of the Minds 18:45 - 20:00 Informal Mixer with Exhibits-Posters Agilent Technologies 41 09:30 - 10:15
Room A Plenary Lecture
Chair J. Labaer
09:30 - 10:15 ADVANCES IN EXPRESSION AND INTERACTION PROTEOMICS
Keynote Matthias Mann Speaker Max-Planck Institute of Biochemistry, Munich, Germany
10:20 - 11:00
Coffee Break - Exhibition Hall
11:00 - 12:50
Room A Integrative Proteomics and Systems Biology
Chairs L. Serrano M. Ueffing
11:00 - 11:25 PROTEIN INTERACTION COMPETITION IN CELL SIGNALLING
Keynote Luis Serrano Speaker Centre for Genomic Regulation, Barcelona, Spain
11:25 - 11:50 FUNCTIONAL RELATIONSHIPS IN PROTEIN NETWORKS
Keynote Marius Ueffing Speaker Helmholtz Zentrum Munich, Germany
11:50 - 12:05 OP046 - DEEP PROTEOMICS, TRANSCRIPTOMICS AND SYSTEMS BIOLOGY ANALYSIS OF VASCULAR SMOOTH MUSCLE CELLS REVEALS NOVEL ANGIOTENSIN II –REGULATED PATHWAYS UNDERLYING VASCULAR WALL THICKENING
Fernando Garcia-Marques National Cardiovascular Research Centre, Madrid, Spain
12:05 - 12:20 OP047 - OSTEOGENESIS IMPERFECTA: AFFECTED PATHWAYS IN SKIN, BONE, AND LUNG FROM THE BRTLIV MURINE MODEL
Laura Bianchi University of Siena, Italy
12:20 - 12:35 OP048 - PROTEOMIC CHARACTERISATION OF TIO2 NANOPARTICLE- PROTEIN CORONA FORMATION IN VITRO
Ana Paula Farinha Linköping University, Sweden
42 12:35 - 12:50 OP049 - PROTEOMICS MOVES FROM EXPRESSION TO TURNOVER: UNDERSTANDING THE DYNAMIC PROTEOME
Mary Doherty University of The Highlands And Island, Inverness, United Kingdom
Room B Cancer Proteomics II
Chairs D. Fenyo C. Jiménez
11:00 - 11:25 BREAST CANCER: MOLECULAR PROFILING OF A MOVING TARGET
Keynote Peter James Speaker Lund University, Sweden
11:25 - 11:50 FROM CANCER PROTEOMICS TO PROTEIN BIOMARKERS, DRUG TARGETS AND CLINICAL APPLICATIONS
Keynote Conny Jimenez Speaker VU University Medical Center, Amsterdam, The Netherlands
11:50 - 12:05 OP050 - PUTTING THE PROTEOME TO WORK: NEW ADVANCES FOR CANCER RESEARCH
Carol Nilsson University of Texas Medical Branch, Galveston, USA
12:05 - 12:20 OP051 - HIGHLY MULTIPLEXED IMAGING OF TUMOR TISSUES WITH SUBCELLULAR RESOLUTION BY MASS CYTOMETRY
Bernd Bodenmiller University of Zurich , Switzerland
12:20 - 12:35 OP052 - SUITABILITY OF A CANCER PROTEOMICS SAMPLE
Christopher Kinsinger National Cancer Institute, Bethesda, USA
12:35 - 12:50 OP053 - AN INTER-CANCER STUDY OF HUMAN PLASMA PROTEINS BY GLYCOSWATH MASS SPECTROMETRY
Tatjana Sajic ETH Zurich, Switzerland
Room C Immunobiology and Cell Signaling
Chairs A. Admon O. Acuto
43 11:00 - 11:25 THE HLA PEPTIDOME PRODUCTION PIPELINE
Keynote Arie Admon Speaker Israel Institute of Technology, Haifa, Israel
11:25 - 11:50 PROTEOMICS SURVEY OF T CELL ACTIVATION AND DIFFERENTIATION
Keynote Oreste Acuto Speaker University of Oxford, United Kingdom
11:50 - 12:05 OP054 - QUANTITATIVE PROTEOMICS TO STUDY PROTEIN SECRETION FROM IMMUNE CELLS
Felix Meissner MPI of Biochemistry, Munich, Germany
12:05 - 12:20 OP055 - A SYSTEMATIC PROTEOMICS-BASED APPROACH TO GENERATING IMMUNOTHERAPEUTICS BASED ON HIGH AFFINITY SOLUBLE T CELL RECEPTORS
Alex Powlesland Immunocore Ltd, Abingdon, United Kingdom
12:20 - 12:35 OP056 - IN-DEPTH ANALYSIS OF HLA-I PEPTIDOMES REVEALS THAT PROTEIN ABUNDANCE AND TURNOVER STRONGLY AFFECTS PRESENTATION – IMPLICATIONS FOR IMMUNOTHERAPY OF MELANOMA
Michal Bassani-Sternberg Max Planck Institute For Biochemistry, Martinsried, Germany
12:35 - 12:50 OP057 - OMICS ANALYSES PROVIDE EVIDENCE FOR PERITONEAL IMMUNE-MODULATION BY AN ALANYL-GLUTAMINE CONTAINING PERITONEAL DIALYSIS SOLUTION
Klaus Kratochwill Medical University of Vienna, Austrian
Room D REDOX Proteomics and Mitochondrial Biology
Chairs J. Vázquez E. Murphy A. Martinez
11:00 - 11:25 NOVEL APPROACHES FOR THE STUDY OF THE DYNAMIC BEHAVIOR OF THE MITOCHONDRIAL REDOXOME AND SUPERCOMPLEXOME
Keynote Jesús Vázquez Speaker National Cardiovascular Research Centre , Madrid, Spain
11:25 - 11:50 SIGNALING BY S-NITROSYLATION IN THE HEART
Keynote Elizabeth Murphy Speaker National Heart, Lung, and Blood Institute, Bethesda, USA
44 11:50 - 12:05 OP058 - GLOBAL PROTEIN OXIDATION PROFILING OF PODOSPORA ANSERINA MITOCHONDRIA SUGGESTS EFFICIENT REMOVAL OF DAMAGED PROTEINS EVEN AT HIGH AGE
Ansgar Poetsch Ruhr University Bochum, Germany
12:05 - 12:20 OP059 - A DECADE OF MITOCHONDRIAL PROTEOMICS
Julia Maria Burkhart Leibniz-Institut Für Analytische Wissenschaften - ISAS - E.V., Dortmund, Germany
12:20 - 12:35 OP060 - PROTEOMIC CHARACTERIZATION OF CYSTEINE OXIDATION IN INS-1E CELLS IN RESPONSE TO CYTOKINES STIMULATION
Honggang Huang University of Southern DenmarK, Odense M.,Denmark
12:35 - 12:50 OP061 - CONCURRENT ANALYSIS OF REVERSIBLE CYSTEINE OXIDATIONS: S-NITROSYLATION AND S-SULFONYLATION
Adelina Rogowska-Wrzesinska University of Southern DenmarK, Odense M.,Denmark
Room E EuPA Initiatives
Chairs G. Corthals A. Urbani
11:00 - 11:22 STANDARDISATION
F. Canals Vall D’Hebron Institute Of Oncology (VHIO) , Barcelona, Spain
11:22 - 11:44 BIOBANKS AND PROTEOMICS
A Wheelock Karolinska Institutet, Stockholm, Sweden
11:44 - 12:06 MS IMAGING
L. McDonnell Leiden University Medical Center, The Netherlands
12:06 - 12:28 MODEL ORGANISMS
E. Bendixen Aarhus University, Denmark
12:28 - 12:50 FUTURE PERSPECTIVES
G. Corthals Turku Centre for Biotechnology, finland
45 13:00 - 14:15 Lunch Seminars / Lunch Break
14:15 - 15:45 Poster Session
Even-numbered poster boards present
16:00 - 16:45 Plenary Lecture
Chair M. C.M. Chung
16:00 - 16:45 SIGNALING INTERACTOME DYNAMICS IN HEALTH AND DISEASE
Keynote Anne-Claude Gingras Speaker Lunenfeld-Tanenbaum Research Institute, Toronto, Canada
16:45 - 18:35
Room A Glycoproteomics in Biology and Diseases
Chairs N. Taniguchi A. García
16:45 - 17:10 FUT8-/- MICE WHICH LACK THE CORE FUCOSE STRUCTURE SHOW THE UPREGULATED GNT-III GENE AND ITS PRODUCT, A BISECTING GLCNAC: A POSSIBLE ADAPTIVE AND COMPENSATORY MECHANISM FOR GLYCAN FUNCTION
Keynote Naoyuki Taniguchi Speaker RIKEN Advanced Science Institute, Osaka, Japan
17:10 - 17:35 COMBINATION OF GLYCOPROTEOMICS TECHNOLOGIES UTILIZED IN SUCCESSFUL DEVELOPMENT OF DIAGNOSTIC SYSTEMS
Keynote Hisashi Narimatsu Speaker National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan
17:35 - 17:50 OP062 - GLYCOPROTEOMIC IDENTIFICATION OF CELL SURFACE ATTACHMENT MOLECULES FOR ENTEROVIRUS 71
Chuan-Fa Chang National Cheng Kung University, Tainan, Taiwan
17:50 - 18:05 OP063 - PRONOUNCED DIFFERENCES IN GLYCOSYLATION PROFILES OF HUMAN PANCREATIC ADENOCARCINOMA CELL LINES AFFECT THEIR RECOGNITION BY LECTIN RECEPTORS
Stephanie Holst§ LUMC, Center For Proteomics And Metabolomics, Leiden, The Netherlands 46 18:05 - 18:20 OP064 - CHARACTERIZATION OF THE COMPETITION BETWEEN ASPIRIN-ACETYLATION AND GLYCATION ON HUMAN PLASMA PROTEINS
Francesco Finamore University of Geneva, Switzerland
18:20 - 18:35 OP065 - COMPREHENSIVE N-GLYCOME PROFILING OF CULTURED HUMAN EPITHELIAL BREAST CELLS IDENTIFIES UNIQUE SECRETOME N-GLYCOSYLATION SIGNATURES ENABLING TUMORIGENIC SUB-TYPE CLASSIFICATION
Ling Lee Macquarie University , Sidney, Australina
Room B Inflammatory and Rheumatic Diseases
Chairs F.Blanco K. Marcus
16:45 - 17:20 SPANISH HPP-16 CONSORTIUM: THE B/D APPROACH OF THE RHEUMATIC DISEASES
Keynote Francisco Blanco Speaker Instituto de Investigación Biomédica de A Coruña (INIBIC), Spain
17:20 - 17:35 OP066 - AUTOANTIBODIES IN THE SERA OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
Caroline May Ruhr-University Bochum, Germany
17:35 - 17:50 OP067 - 2D-DIGE/MS ANALYSIS ALLOWS THE IDENTIFICATION OF A DISTINCT SERUM PROTEIN PROFILE IN CD38-DEFICIENT MICE ASSOCIATED WITH EITHER COLLAGEN-INDUCED ARTHRITIS OR INFLAMMATION
Jaime Sancho Instituto de Parasitología y Biomedicina López-Neyra (IPBLN) Armilla, Spain
17:50 - 18:05 OP068 - PROTEOMIC STUDIES OF HMGB1 INVOLVEMENT IN LUNG INFLAMMATION
Alexander Kurosky University of Texas Medical Branch , USA
18:05 - 18:20 OP069 - MOLECULAR PROFILING OF AUTOIMMUNE DISEASE FOR IMPROVED DIAGNOSIS, PROGNOSIS, AND CLASSIFICATION
Christer Wingrem Lund University, Sweden
18:20 - 18:35 OP070 - DETECTION OF BACTERIAL AND HOST PROTEINS IN PEDIATRIC ULCERATIVE COLITIS FROM A SINGLE COLONIC BIOPSY SAMPLE BY SWATH-MS
Petri Kouvonen University of Turku, Turku, Finland
47 Room C Proteomics of Human Microbiome and Infectious Diseases
Chairs I. Cristea L. Monteoliva
16:45 - 17:10 UNDERSTANDING CELLULAR HOST DEFENSE AGAINST VIRAL INFECTION: LESSONS FROM PROTEOMICS
Keynote Ileana Cristea Speaker Princeton University, USA
17:10 - 17:35 PROTEOMICS-BASED OPERATIONAL PIPELINES FOR ADVANCED GUT MICROBIOTA ANALYSES
Keynote Lorenza Putignani Speaker Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
17:35 - 17:50 OP071 - AN OPTIMIZED METAPROTEOGENOMIC PIPELINE FOR IN-DEPTH CHARACTERIZATION OF THE MOUSE GUT MICROBIOME
Alessandro Tanca Porto Conte Ricerche, Alghero, Italy
17:50 - 18:05 OP072 - HIGH-RESOLUTION LC-MS ANALYSIS OF TARGET CELLS TREATED WITH CLOSTRIDIUM DIFFICILE TOXINS
Andreas Pich Hannover Medical School, Germany
18:05 - 18:20 OP073 - HIGH-THROUGHPUT TARGETED SWATH-MS PROTEOMICS OF A HUMAN PATHOGEN IMPLICATES NOVEL PROTEIN QUANTITATIVE TRAIT LOCI (PQTL) IN THE REGULATION OF KEY VIRULENCE FACTORS
Röst Hannes ETH Zurich, Switzerland
18:20 - 18:35 OP074 - PROTEOMICS UNRAVELS EXTRACELLULAR VESICLES AS CARRIERS OF MOONLIGHTING PROTEINS IN CANDIDA ALBICANS
Ana Gil de Bona Universidad Complutense de Madrid, Madrid, Spain
Room D Standardisation in Proteomics: Tribute to Juan Pablo Albar
Chairs C.H. Borchers A. Paradela
16:45 - 17:10 INTER-LABORATORY EVALUATION OF STANDARDIZATION KITS FOR QUANTITATIVE PLASMA PROTEOMICS
Keynote Christoph H Borchers Speaker University of Victoria, Canada
48 17:10 - 17:35 QUANTIFICATION OF ONCOGENIC SIGNALLING BY PHOSPHOPROTEOMICS
Keynote Pedro Cutillas Speaker Queen Mary University of London, United Kingdom
17:35 - 17:50 OP075 - SCRIPT-MAP, A DATABASE OF “BEST-RESPONDERS”, PUSHES ACCURACY IN MS QUANTIFICATION
Chen Ding Beijing Institute of Radiation Medicine, China
17:50 - 18:05 OP076 - THE MZTAB DATA STANDARD FORMAT FOR REPORTING MS-BASED PEPTIDE, PROTEIN AND SMALL MOLECULE IDENTIFICATION AND QUANTIFICATION RESULTS
Johannes Griss Medical University Of Vienna, Austria
18:05 - 18:20 OP077 - EXPEDIENTS IN PROTEOMIC RESEARCH - STANDARDISATION AND OPTIMIZED PROTOCOLS
Albert Sickmann ISAS, Dortmund, Germany
18:20 - 18:35 OP078 - AN AUTOMATED QUALITY CONTROL PLATFORM FOR NANOLC-MS BASED PROTEOMICS
Daniel Lopez-Ferrer Thermo Fisher Scientific, San Jose, USA
Room E EuPA Company News Corner EuPA/HUPO MADRID
About the EuPA Company Club
The EuPA Company Club Concept was first presented in September 2011. Companies involved in Proteomics Technologies are invited to join the Club as a platform for direct interaction with the Proteomics Community at the European level and to support correspondingly EuPA’s Educational mission.
Participation in EuPA’s high level Educational activities provides prospective visibility for the next generation of researchers in the Proteomics field. EuPA is the organisation optimally positioned to achieve this. Both together, the Company Club members and EuPA, will eventually create a platform for a fruitful cooperation in building a system of EuPA endorsed courses at different levels giving companies high visibility as important players in the field.
About the of EuPA Company News Corner
The EuPA Company Club News Corner is established at Annual EuPA Conferences as a dedicated platform for member companies where they can present latest developments. New solutions arriving from continuous engineering efforts to improve equipment and reagents for research in Proteomics will be orally presented by leading technology providing companies in the “News Corner” session. 49 16:45 - 17:00 EUPA COMPANY CLUB - INTRODUCTION AND OUTLOOK
Peter Verhaert Delft University of Technology, The Netherland
17:00 - 17:15 NEW TRIPLETOF® 6600 AND SWATHTM 2.0 FOR NEXT GENERATION PROTEOMICS AND QUANTITATIVE BIOLOGY
Joerg Dojahn AB Sciex
17:15 - 17:30 DEVELOPMENT, IMPLEMENTATION AND APPLICATION OF PERFORMANCE / ASSESSMENT KITS FOR QUANTITATIVE PROTEOMIC STUDIES
Andrew Percy Agilent Technologies
17:30 - 17:45 PROTEOMICS BEYOND BOUNDARIES WITH A NEW UHR-QTOF SYSTEM
Carsten Baessmann Bruker
17:45 - 18:00 MEASURING PROTEIN´S ACTIVITY, QUANTITY AND FUNCTION BY MULTIPLEXED BEAD-ARRAYS - APPLICATIONS IN BIOMEDICAL RESEARCH
Oliver Poetz Luminex
18:00 - 18:15 COMPARATIVE TWO DIMENSIONAL FLUORESCENT ELECTROPHORESIS (COFGE)
Simone König SERVA
18:15 - 18:30 APPLICATION OF PROTEOMICS TECHNOLOGIES TO DRUG DEVELOPMENT – CURRENT STATUS AND CHALLENGES
Fabian Milz PROTAGEN
18:45 - 20:00 Informal Mixer with Exhibits-Posters
50 51 SCIENTIFIC PROGRAM Wednesday October 8th
52 Room A Room B Room C Room D Room E Room F Room G Room H Room I HPP Morning Sessions
Computational 08:00 - 09:20 Respiratory Protein C-HPP III Cardiovascular Mass Mitochondria PediOME diseases Aggregation Spectrometry
09:30 - 10:15 Plenary Lecture
10:20 - 11:00 Coffee Break - Exhibition Hall
Cardiovascular and From Siena to Technological haematological Madrid, 20 years of Mapping Neurological horizons. MS imaging, 11:00 - 12:50 proteomics: proteomics: tribute the Human disorders targeted proteomics, tribute to to Friederich Proteome others Mike Dunn Lottspeich
13:00 - 14:15 Lunch Break
14:15 - 15:00 Poster Session
Interactomics Computational Proteomics of and beyond. Human proteomics. Data neglected 15:00 - 16:50 Protein Proteome Project analysis and tropical networks and biostatistics diseases pathways
Awards Session 16:50 - 18:15 (HUPO & EuPA)
18:15 - 19:30 Closing Ceremony 53 09:30 - 10:15
Room A Plenary Lecture
Chair A. Bairoch
09:30 - 10:15 DEMOCRATIZATION OF ADVANCES IN MS-BASED PROTEOMICS TOOLS AND RESOURCES
Keynote Rob Moritz Speaker Institute for Systems Biology, Seattle, USA
10:20 - 11:00 Coffee Break - Exhibition Hall
11:00 - 12:50
Room A Cardiovascular and Haematological Proteomics: Tribute to Mike Dunn
Chairs M. Mayr F. Vivanco
11:00 - 11:25 TRIBUTE TO MIKE DUNN: Paying forward
Jennifer Van Eyk Cedar Sinai Medical Center, Los Angeles, USA
Michael J. Dunn UCD Conway Institute. Dublin Ireland
Hans-Joachim Kraus Wiley-VCH Verlag. Weinheim, Germany
11:25 - 11:50 INTEGRATION OF PROTEOMICS AND LIPIDOMICS - OPPORTUNITIES AND CHALLENGES IN CARDIOVASCULAR SYSTEMS BIOLOGY
Keynote Manuel Mayr Speaker King’s College London, United kingdom
11:50 - 12:15 A MULTIOMIC APPROACH TO UNDERSTANDING ATHEROSCLEROSIS
Fernando Vivanco IIS-Fundacion Jimenez Diaz, Madrid, Spain
12:15 - 12:30 OP079 - QUANTITATIVE MEMBRANE PROTEOME PROFILING TO DISCOVER THERAPEUTIC TARGETS FOR HTLV-I ASSOCIATED DISEASES
Makoto Ishihara The University of Tokyo, Japan
12:30 - 12:45 OP080 - A PROTEOMIC INSIGHT TO A NOVEL THERAPEUTIC TARGET FOR MYOCARDIAL INFARCTION
54 Agnese Petrera University of Freiburg, Germany 12:45 - 12:50 OP081 - PROTEOMIC ANALYSES OF ARCHIVAL FORMALIN-FIXED PARAFFIN-EMBEDDED HUMAN AORTAS STORED FOR 25 YEARS
Zongming Fu Johns Hopkins University School of Medicine, Maryland, USA
Room B Neurological Disorders
Chairs H. Meyer M. Fuentes
11:00 - 11:35 WHAT TRIGGERS THE ONSET AND PROGRESSION OF ALZHEIMER’S DISEASE?
Keynote Helmut Meyer Speaker Ruhr-University Bochum, Germany
11:35 - 11:50 OP082 - BROAD-SCALE ANTIGEN ARRAY PROFILING PROVIDES NOVEL INSIGHTS INTO AUTOIMMUNE TARGETS IN MULTIPLE SCLEROSIS
Burcu Ayoglu KTH Royal Institute of Technology, Stockholm, Sweden
11:50 - 12:05 OP083 - TARGETING SYNAPTIC PATHOLOGY IN ALZHEIMER’S DISEASE – AFFINITY MASS SPECTROMETRY AS A TOOL IN BIOMARKER DISCOVERY AND CLINICAL DIAGNOSIS
Ann Brinkmalm The University of Gothenburg, Sweden
12:05 - 12:20 OP084 - A NEW CEREBROSPINAL FLUID 16PLEX ASSAY FOR NEURODEGENERATION
Christopher Lößner Proteome Sciences plc, London, United Kingdom
12:20 - 12:35 OP085 - ISOLATION OF MULTIPROTEIN COMPLEXES AND SYNAPSE PROTEOMES FROM HUMAN POST-MORTEM BRAIN
Àlex Bayés Biomedical Research Institue Sant Pau, Barcelona, Spain
12:35 - 12:50 OP086 - A SINGLE DOSE OF THE GAMMA-SECRETASE INHIBITOR SEMAGACESTAT ALTERS THE CEREBROSPINAL FLUID PEPTIDOME IN HUMANS
Johan Gobom University of Gothenburg, Sweden
Room C Technological horizons
Chairs B. Domon E. Oliveira
55 11:00 - 11:25 ADVANCES IN HIGH-RESOLUTION QUANTITATIVE PROTEOMICS
Keynote Bruno Domon Speaker Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg
11:25 - 11:40 OP087 - APPLICATION OF A NOVEL INTEGRATED MICROFUIDICS DEVICE FOR HIGH-THROUGHPUT LC-MS MRM DISEASE PROTEIN MARKER VERIFICATION
Lee Gethings Waters Corporation, Wilmslow, United Kingdom
11:40 - 11:55 OP088 - A NOVEL SWATH-MS PLATFORM FOR COMPREHENSIVE CHARACTERIZATION OF THE EPIGENETIC HISTONE MODIFICATIONS
Sahana Mollah AB SCIEX, Redwood City, USA
11:55 - 12:10 OP089 - TOWARDS QUANTIFICATION BASED MS IMAGING: FILLING THE GAP BETWEEN MALDI MS IMAGING AND TISSUE MICROPROTEOMICS
Isabelle Fournier Université Lille 1, France
12:10 - 12:25 OP090 - TARGETED PROTEOMICS VIA AUTOMATED, HIGH PRECISION TRYPTIC DIGESTION AND SISCAPA-MS QUANTIFICATION OF HUMAN PLASMA PROTEINS USING THE AGILENT BRAVO PLATFORM
Selena Larkin SISCAPA Assay Technologie, Dublin USA
12:25 - 12:40 OP091 - JUST ANOTHER FISHING EXERCISE? STABLE ISOTOPE LABELLING STRATEGIES TO INVESTIGATE THE DYNAMIC PROTEOME
Mary Doherty University of The Highlands And Islands, United Kingdom
12:40 - 12:50 PROTEOME ANALYZER. CURRENT STATE
Bruno Domon Luxembourg Clinical Proteomics Center (LCP), Luxembourg
Room D From Siena to Madrid, 20 years of proteomics: Tribute to Fiedrich Lottspeich
Chairs J. C. Sanchez L. Bini
11:00 - 11:10 INTRODUCTION
Luca Bini University of Siena, Italy
11:10 - 11:30 AFTER 20 YEARS OF PROTEOMICS – IS THE VISION STILL ALIVE?
Friederich Lottspeich Max-Planck-Institute of Biochemistry, Munich, Germany 56 11:30 - 11:50 FROM SINGLE PROTEIN IDENTIFICATION TO PROTEOMIC SYSTEMS BIOLOGY IN 20 YEARS
Mathias Mann Max-Planck Institute of Biochemistry, Munich, Germany
11:50 - 12:10 20 YEARS OF PROTEOMICS: WHAT DOES HISTORY TELL US ABOUT THE FUTURE?”
Ruedi Aebersold Institute of Molecular Systems Biology, Zurich, Switzerland
12:10 - 12:30 TISSUE-BASED MAP OF THE HUMAN PROTEOME
Mathias Uhlen KTH Royal Institute of Technology, Stockholm, Sweden
12:30 - 12:50 SHOULD WE REALLY TRUST AUTOMATED HT PEPTIDE IDENTIFICATION?
Peter James Lund University, Sweden
Room E Mapping the Human Proteome
Chairs L. Martens E. Deustch
11:00 - 11:25 MASS SPECTROMETRY BASED DRAFT OF THE HUMAN PROTEOME
Keynote Bernhard Kuster Speaker Technische Universität München, Freising, Germany
11:25 - 11:50 PROBING DEEPER INTO THE HUMAN PROTEOME
Keynote Akhilesh Pandey Speaker Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
11:50 - 12:05 OP092 - PROTANNOTATOR: A SEMIAUTOMATED PIPELINE FOR CHROMOSOME-WISE FUNCTIONAL ANNOTATION OF THE “MISSING” HUMAN PROTEOME
Shoba Ranganathan Macquarie University, Sydney, Australia
12:05 - 12:20 OP093 - PROTEOMICS STUDIES SUGGEST THAT THERE ARE JUST 19,000 PROTEIN CODING GENES IN THE HUMAN GENOME
Michael Tress Spanish National Cancer Research Centre (CNIO), Madrid, Spain
12:20 - 12:35 OP094 - BIOINFORMATICS PIPELINE AND MASS SPECTROMETRY-BASED METHODOLOGIES FOR THE DISCOVERY OF MISSING PROTEINS: THE CASE OF HUMAN CHROMOSOME 2 AND 14
Yves Vandenbrouck CEA, Life Science Division, Grenoble, France
57 12:35 - 12:50 OP095 - PROTEOGENOMICS DASHBOARD FOR THE HUMAN PROTEOME PROJECT
Alberto Pascual-Montano National Center For Biotechnology-CSIC, Madrid, Spain
13:00 - 14:15 Lunch Seminars / Lunch Break
14:15 - 15:45 Poster Session
All poster boards are free to present
15:00 - 16:50
Room A Human Proteome Project
Chairs G. Omenn Y. K. Paik
15:00 - 15:25 COMPARATIVE PROTEOMICS AND THE ROLE OF MULTI-ORGANISM PROTEOMES IN THE HPP
Keynote Emøke Bendixen Speaker Aarhus University, Denmark
15:25 - 15:50 MULTILAYERED GENETIC AND OMICS DISSECTION OF MITOCHONDRIAL ACTIVITY
Keynote Johan Auwerx Speaker École Polytechnique Fédérale, Lausanne, Switzerland
15:50 - 16:05 OVERVIEW OF PROGRESS, STRATEGIES, AND METRICS OF THE HUMAN PROTEOME PROJECT
Gilbert Omen University of Michigan Medical Center, USA
16:05 - 16:20 LEVERAGING THE GENOME-WIDE PROTEOME PARTS TO STUDY DISEASE BIOMARKERS THROUGH FUNCTIONAL VALIDATION OF MISSING PROTEINS
Young-ki Paik Yonsei University, Seoul, Korea,
16:20 - 16:35 MULTIPLEXED AND SENSITIVE PROTEIN QUANTITATION OF FRACTIONATED HUMAN PLASMA BY MRM/MS WITH ISOTOPICALLY LABELED STANDARD Andrew Percy UVic-Genome BC Proteomics Centre, Victoria, BC, Canada
16:35 - 16:50 PANEL AND GENERAL AUDIENCE DISCUSSION
Ruedi Aebersold, Catherine Costello, Bill Hancock, Pierre Legram, Michael Snyder, Mathias Uhlen, Jennifer Van Eyk 58 Room B Interactomics and Beyond. Protein Networks and Pathways
Chairs M.Gstaiger P. Roepstorff
15:00 - 15:50 INTERACTION PROTEOMICS: CURRENT CHALLENGES AND EMERGING IMPLICATIONS
Keynote Matthias Gstaiger Speaker Swiss Federal Institute of Technology Zurich (ETH), Switzerland
15:50 - 16:05 OP096 - LARGE SCALE IDENTIFICATION OF PHOSPHO-DEPENDENT PROTEIN- PROTEIN INTERACTIONS
Ulrich Stelzl Max Planck Institute For Molecular Genetics (MPI), Berlin, Germany
16:05 - 16:20 OP097 - HIGHLY ACCURATE PROTEIN COMPLEX RETRIEVAL BY AFFINITY ENRICHMENT MS RATHER THAN AFFINITY PURIFICATION MS
Eva C. Keilhauer Max Planck Institute of Biochemistry, Martinsried, Germany
16:20 - 16:35 OP098 - AP-MS AND BIOID ANALYSIS OF THE HBX VIRAL-HOST INTERACTOME
Emanuela Milani Institute of Molecular Systems Biology ETH, Zurich, Switzerland
16:35 - 16:50 OP099 - UNTANGLING THE COLORECTAL CANCER EGFR/ERBB NETWORK USING A TRIPLE SILAC AP/MS APPROACH
Cinzia Raso University College of Dublin, Ireland
Room C Computational Proteomics. Data Analysis and Biostatistics
Chairs H. Hermjakob A. Pascual
15:00 - 15:25 EXPANDING THE SCOPE, SCALE, AND REPRODUCIBILITY OF TARGETED PROTEOMICS
Keynote M. MacCoss Speaker University of Washington, USA
15:25 - 15:50 PROTEOMEXCHANGE - AN INTERNATIONAL INFRASTRUCTURE FOR OPEN PROTEOMICS DATA
Keynote Henning Hermjakob Speaker European Bioinformatics Institute (EMBL-EBI)
59 15:50 - 16:05 OP100 - SEQUENCE VARIANT ANALYSIS WITH INCREASED SPECIFICITY AND MEANINGFUL CONFIDENCES
Sean L Seymour AB SCIEX, Redwood City, USA
16:05 - 16:20 OP101 - RE-ANALYSIS OF PUBLIC DATA: DOES THE FUTURE OF PROTEOMICS LIE IN THE PAST?
Lennart Martens UGent / VIB, Ghent, Belgium
16:20 - 16:35 OP102 - PINT: A NEW PLATFORM FOR THE COMPREHENSIVE INTEGRATION OF COMPLEX LARGE-SCALE PROTEOMICS DATA AND RESULTS
Salvador Martínez-Bartolomé The Scripps Research Institute, San Diego, USA
16:35 - 16:50 OP103 - SCALING UP SPECTRAL CLUSTERING IN THE PRIDE DATABASE
Juan Antonio Vizcaino EMBL-European Bioinformatics Institute, Cambrigde, United Kingdom
Room D Proteomics of Neglected Tropical Diseases
Chairs J.C. Sanchez J.J. Calvete
15:00 - 15:35 SLEEPING-SICKNESS: FROM OMICS DISCOVERY TO A FIELD POINT OF CARE TEST
Keynote Jean-Charles Sanchez Speaker Medical University Centre, Geneva, Switzerland
15:35 - 15:50 OP104 - COMPARATIVE PROTEOMICS OF REPLETE FEMALE TICKS HIGHLIGHTS MOLECULAR MECHANISMS ASSOCIATED WITH BM86 AND SUBOLESIN VACCINE PROTECTION
Margarita Villar Instituto de Investigación en Recursos Cinegéticos, Ciudad Real, Spain
15:50 - 16:05 OP105 - ROLE OF STAGE SPECIFIC LEISHMANIA A600 PROTEINS IN CELLULAR DIFFERENTIATION AND METABOLISM
Robert McMaster University of British Columbia, Vancouver, Canada
16:05 - 16:20 OP106 - DISCOVERING UNIQUE PEPTIDES WITHOUT A SEQUENCE DATABASE
Sule Yılmaz University Of Gent, VIB, Belgium
16:20 - 16:35 OP107 - QUANTITATIVE PROTEOMIC ANALYSIS OF HUH 7 CELLS INFECTED WITH DENGUE VIRUS BY LABEL-FREE LC-MS
Victoria Pando-Robles Instituto Nacional De Salud Pública, Morelos, Mexico 60 16:50 - 18:15 Awards Session (HUPO & EuPA)
Chairs M. Baker L. Bini
HUPO Awards
Distinguished Achievement in Proteomic Sciences Sponsored by Journal of Proteome Research/ ACS Publications Pier Giorgio Righetti
Translational Proteomics Sponsored by Translational Proteomics/ Elsevier Daniel W. Chan
Discovery in Proteomic Sciences Neil L. Kelleher
Science and Technology Award Sponsored by HUPO Industrial Advisory Board Subhasish “Babu” Purkayastha, John Rogers, Rosa Viner, Andrew Thompson
This team of four is nominated for their contributions in the commercialization of isobaric labeling compounds for use in quantitative proteomics. Both programs, ITRAQ (AB SCIEX) and TMT (Thermo Fisher Scientific and Proteome Sciences) are recognized.
EUPA Award Proteomic Pioneer Award in Proteomics Sciences Albert Heck
EuPA Young Investigator Award
HUPO-Madrid 2014 Young Investigator Award
Poster Awards
61 18:15 - 19:30
Closing Ceremony
Chairs P. Legrain G Marko-varga C. Gil F.J Corrales J. Calvete
18:15 - 18:40 GENETIC VARIABILITY AND THE QUANTITATIVE PROTEOME
Keynote Ruedi Aebersold Speaker Institute of Molecular Systems Biology, Zurich, Switzerland CLOSING REMARKS AND ANNOUNCEMENTS
62 HPP Morning Sessions
63 HPP Investigators Meeting - Sunday, October 5, 10:00 - 17:00 Location: Room D
10:00 - 10:10 Overview of Progress, Metrics, and Publications from the HPP Gil Omenn, Chair, HPP, Univ. of Michigan, Ann Arbor, MI, US
10:20 - 10:40 B/D-HPP Highlights, Priority Protein Lists by Disease, Clinician - Scientist Initiative, Workshops Plan + Discussion • Ruedi Aebersold, ETH Zurich, Switzerland • Jennifer Van Eyk, Cedars-Sinai Health System, Los Angeles, CA, US
10:40 - 11:00 C-HPP Highlights, Busan and Bangkok Workshops, Congress Workshops + Discussion • Young-Ki Paik, Chair, C-HPP Initiative, Yonsei Univ., Seoul, Korea • William S. Hancock, Co-Chair, Northeastern Univ., Boston, MA, US
11:00 - 11:55 Update of HPP Metrics: neXtProt (9/14), PeptideAtlas (8/1/14) & GPMdb - Moderator: Gil Omenn Bioinformatics Discussions and Standardized Re-Analyses of Major Datasets of Four Major Publications in 2014: Kim et al (Pandey lab, PXD000561); Wilhelm et al (Kuster lab, PXD000865); Guo et al (Mirzaei lab with various proteolytic enzymes); and TCGA datasets Comments: • Amos Bairoch & Lydie Lane, SIB, Geneva, Switzerland • Eric Deutsch, Inst. Systems Biology, Seattle, WA, US • Akhilesh Pandey, Johns Hopkins & Bangalore; Bernhard Kuster, TUM, Munich; Henry Rodriguez, Bethesda
12:00 - 12:50 Working Lunch Discussion (lunch provided by RSVP only) Inter-Relationships across HPP Components and Bioinformatics Approaches - Bill Hancock From China: Latest Database Search for Evidence of Missing Proteins - Pengyuan Yang
13:00 - 13:30 Antibody and MS Resource Pillars Cross-Validation with Ab and MS Approaches Including MRM Based Quantitation for HPP • Emma Lundberg, SciLifeLab, Stockholm, Sweden ProteomeAnalyzer Project • Bruno Domon, Centre Sante’ Clinical Proteomics Center, Luxembourg
13:30 - 14:00 SSAB Panel, Overview, Strategic Comments from SSAB Members Moderator: Mike Snyder, Stanford Univ., Stanford, CA, US • Cathy Costello, Boston Univ, Boston, MA, US; Matthias Mann, Max Planck, Munich, Germany; Kate Rosenbloom, Univ of California Santa Cruz/ENCODE, US 14:00 - 16:00 Town Hall Meeting Open Forum – on B/D- and C-HPP Collaboration Co-Chairs: Ruedi Aebersold and Young-Ki Paik Part 1. Integrated Data Management “Priority Proteins”/”Popular Proteins”, Including PTMs, Splice Isoforms, SNPs/SAAPs, for Specific Diseases; Use of SRM Peptides, Spectral Libraries, and SRMAtlas • Jennifer Van Eyk, Ruedi Aebersold, Eric Deutsch and B/D Teams ProteomeExchange Experience: PDX Identifiers and Release of Data on Acceptance, Uploading Large Data Sets • Juan Vizcaino, EBI, Hinxton, UK Proteogenomics/RNA Seq, Integrated ‘Omics analyses • Gyorgy Marko-Varga, Jennifer Harlow, Kate Rosenbloom, Michael Snyder (ENCODE) Part 2. Biological Impact of Missing Proteins on C-HPP and B/D-HPP Research Updates from neXtProt on the missing and orphan proteins • Lydie Lane and Amos Bairoch, SIB, Switzerland A Strategy for Bioinformaticians to Take a Deep Dive on Chr-Specific Missing Protein Lists (as discussed in Bangkok C-HPP workshop) • William S. Hancock and Gyorgy Marko-Varga, Co-Chairs, C-HPP Consortium Timing of JPR Special Issue and Standardization of Data Bases for Publication Metrics: What is the Best Theme and Date (middle of 2015) for this Special Issue? • Bill Hancock and Young-Ki Paik, C-HPP Consortium Part 3. Opportunities to Explore Collaborations Within and Between B/D-HPP and C- HPP • Young-Ki Paik and Ruedi Aebersold, entire C-HPP & B/D-HPP Groups
16:00 - 17:00 Meeting of SSAB with HPP-EC for Feedback: Mike Snyder and SSAB Group HPP Early Morning Sessions
The Human Proteome Project (HPP) has grown to become a strong focus of HUPO activities. Most existing HUPO initiatives have found a focus within the HPP and a wide range of new initiatives and projects have also been started by the HPP. All congress attendees are invited to participate in the early morning HPP sessions. These lively, smaller sessions are an invaluable opportunity to connect with colleagues and contribute to the HPP.
Refer to the following pages for detailed description of the initiative sessions Monday, Tuesday and Wednesday mornings 8:00 - 9:20 am. For details on the Wednesday, October 8 HPP Parallel, please refer to the main congress program.
Overview of HPP Early Morning Sessions
Open to ALL Congress Attendees
MONDAY, OCTOBER 6 TUESDAY, OCTOBER 7 WEDNESDAY, OCTOBER 8 08:00 - 09:20 08:00 - 09:20 08:00 - 09:20 HPPP (Plasma) Diabetes Respiratory Diseases Room B Room B Room B
C-HPP, Part I: C-HPP, Part II: Poster Session C-HPP, Part III: PIC New Technology Inside Poster Hall Room C Room C
Cancers I PSI / ProteomeXchange Cardiovascular Room D Room C Room D
iMOP Antibody Proteomics Computational Mass Spec. Room E Room D Room E
Liver Cancers II Mitochondria Room F Room E Room G
Extreme Conditions Glycoproteomics Protein Aggregation Diseases Room G Room F Room H
Infectious Diseases Brain Project PediOme Room H Room G Room I
Stem Cells Room H EyeOme Room I Biobanking & Pre-Analytical Sample Assessment Room I
Please see the following pages for details on each workshop. 64 HPP Early Morning Sessions - Monday, October 6, 2014
Human Plasma Proteome Project (HPPP) Plasma Proteomics Underpins a Translational HPP Organizers: Mark Baker, Martin Kussman, Eric Deutsch, and Simon Fredericksson Room B
8:00 - 8:12 am Loïc Dayon: A Comprehensive and Scalable Automated Workflow for Human Plasma Proteomics and Its Application to the DiOGenes Clinical Study
8:15 - 8:27 am Simon Fredriksson: Multiplexed and Sensitive Immunoassays by the Highly Specific Proximity Extension Assay
8:30 - 8:42 am Eric Deutsch: The PeptideAtlas Plasma Proteome Build
8:45 - 8:50 am Jochen Schwenk: Affinity Proteomics in Plasma from Cancer Biobanks
8:50 - 8:55 am Sadia Mahboob: Targeted Proseek Multiplexed Immunoassays of Candidate Plasma Biomarkers for Dukes’ Stage A-D CRC
8:55 - 9:00 am Tatjana Sajic: An Inter-Cancer Study of Human Plasma Proteins by gly coSWATH Mass Spectrometry
9:00 - 9:20 am Panel: Baker, Aebersold, Omenn, Kussmann, Deutsch, Fredriksson
C-HPP, Part I: New Technology Organizer: Bill Hancock Room C
The following topics will be discussed in the New Technology C-HPP session.
• SRM measurement of missing proteins
• RNA analysis, including predicting when transcript forms protein • Integration of RNA-Seq and proteomics • Approaches to ASV and SNV characterization such as down top MS, adoption of protein chemistry methods • Identification of protein families and sharing of specific data across chromosome families
65 HPP Early Morning Sessions - Monday, October 6, 2014
Cancer I Organizers: Hui Zhang, Christopher Kinsinger and Edouard Nice Room D
8:00 - 8:10 am Hui Zhang: Overview of the Ca-B/D HPP
8:10 - 8:25 am Ruedi Aebersold: Quantifying Cancer Related Proteins via Targeting MS Assay
8:25 - 8:40 am Christopher Kinsinger: The CPTAC Initiative
8:40 - 8:55 am Robert Moritz: MRM
8:55 - 9:10 am Edouard Nice: Towards the Human Proteome Analysis of Alternate Clinical Samples
9:10 - 9:20 am Open Discussion
iMOP Organizers: Emøke Bendixen, Sabine Schrimpf Room E
8:00 - 8:05 am Emøke Bendixen: Introduction
8:05 - 8:25 am Erik Bongcam-Rudloff: The ALLBIO Project, Beyond Human Centric Bioinfor matics Resources
8:25 - 8:45 am Fabrize Bertil: Deciphering New Anti-Obesity Mechanisms Using Non-Se quenced Species
8:45 - 9:10 am Dorothea Rutishauser: Levels of Chemosensory and Odorant-Binding Pro teins from Caterpillar Saliva are Affected by Host Plant and Immune Challenge
9:10 - 9:20 am Open discussion
66 HPP Early Morning Sessions - Monday, October 6, 2014
Human Liver B/D Initiative Organizers: Pumin Zhang and Fernando J. Corrales Room F
The Human Liver Proteome Project (HLPP) was launched in 2002, aiming to establish a biological atlas of the human liver, uncover the proteomic basis of liver development, physiology and pathology, and develop diagnostics and therapeutics for liver diseases. It is a large-scale international collaborative initiative of the Human Proteome Project (HPP). In the past decade, under the efforts of HLPP international consortium, HUPO has set up standard operating procedures, optimized the strategies for proteomic analysis and investigated the proteomes of liver tissues, healthy and diseased. More specifically, in 2010, Human Liver 1.0 was published, in which 6788 gene products have been identified, whilst in 2013, proteome of liver cellular organelles was profiled and totally 12,168 gene products in human liver were identified. The next goals will be, first, to profile the four major cell types in the liver to produce Liver Proteome 3.0 that will include around 13,000 proteins in total; second, to investigate post-translational modifications of liver proteins, and finally, focusing on the Biology/Disease (B/D)-driven Liver Proteome Project and looking for biomarkers for liver disease.
This session will feature talks from the following speakers:
• Opening Remarks: Pumin Zhang (Baylor College of Medicine, USA) • Reference Material-Based Liver Proteome Quantitation: J Eugene Lee (Korea Research Institute of Standards and Science, Korea) • Proteomic Analysis of Human Urine Exosomes and Hepatoblastoma Tissue Samples by Label-Free nLC MS/MS: Felix Elortza (CIC bioGUNE) • Deciphering Essential Genes by Comparative Analysis Transcriptoproteome of Liver Tissue and HepG2 Cell Line: Andrey Lisitsa (Institute of Biomedical Chemistry, Russia) • From Protein Lists to the Pathogenesis of Chronic Liver Disorders. Role of One Carbon Metabolism: Fernando J Corrales (CIMA, University of Navarra, Spain) • Proteomics on Post-Translation Modifications of Proteins: Ping Xu (Beijing Proteome Research Center, China) • Laura Beretta (MD Anderson Cancer Center, USA) • New Cell Biology through the study of Human Fatty Liver Disease: Tommy Nilsson (McGill University, Canada) • Characterization of Altered Membrane Lipid Profiling in Hepatocellular Carcinoma • Progression: Pengyuan Yang (Fudan University, China) 67 HPP Early Morning Sessions - Monday, October 6, 2014
Extreme Conditions Organizer: Evgeny Nikolaev and Irina Larina Room G
8:00 - 8:05 am Evgeny Nikolaev: Introduction
8:05 - 8:20 am Irina Larina: Adaptation of Human Organism to Long Space Flight (Institute of Biomedical Problems, Moscow, Russia)
8:20 - 8:30 am Saik Olga: System for Automated Literature Mining and Protein Interactome Networks Reconstruction (Institute of Cytology and Genetics, Novosibirsk)
8:30 - 8:40 am Igor Popov: Technical Aspects of Proteomic Assays of People Under Extreme Conditions (Talroze Institute for Energy problems of Chemical Physics, Mos cow Institute of Physics and Technology, Dolgoprudnyj, Russia)
8:40 - 8:50 am Alexey Kononikhin: Proteomics of Exhaled Breath Condensate of People in Extreme Conditions (Talroze Institute for Energy problems of Chemical Phys ics, Moscow Institute of Physics and Technology, Dolgoprudnyj, Russia)
8:50 - 9:00 am Ludmila Pastushkova: Cardiovascular Proteins in the Urine of Healthy Volun teers During the “Dry” Immersion; (Institute of Biomedical Problems, Moscow, Russia)
9:00 - 9:10 am Andrew Chambers: Plasma and Urine MRM Assay Development for the Cos monaut Samples (UVic-Genome BC Proteomics Centre, Victoria, Canada)
9:10 - 9:20 am Bruno Domon, Nina Khristenko, Irina Larina, Eugene Nikolaev: Systematic Analysis of Proteins in Urine Samples; Application to the Mars-500 Program; (Luxembourg Clinical Proteomics, (Institute of Biomedical Problems, Moscow, Russia, Institute for Energy problems of Chemical Physics, Moscow, Russia)
68 HPP Early Morning Sessions - Monday, October 6, 2014
Infectious Diseases (HID) Organizers: Ileana Cristea and Concha Gil Room H
Infectious diseases are disorders caused by (micro) organisms (viruses, bacteria, fungi and parasites). These have the potential to rapidly become global epidemics and pandemics, and are a leading cause of human disease and death worldwide, in particular in low income countries. Lower respiratory infections, HIV/AIDS and diarrheal diseases are ranked in the top ten causes of death globally, whereas malaria and tuberculosis are two of the major ten causes of death in low income countries. In developed countries infectious diseases are also important in immunosuppressed patients and transplant recipients. New diagnostic tests and therapeutic agents are required to reduce the mortality of these infectious diseases.
8:00 - 8:05 am HID-HPP Initiative Introduction
8:05 - 8:40 am Round Table Discussion Panelists: Ileana Cristea, Concha Gil, Manuel Fuentes, Sanjeeva Srivastava, Rafa Cantón, Jesús Fortún, Catherine Costello, Christopher Overall, Frank Schmidt, Joshua LaBaer, Peter Nilsson
Key discussion points:
A. How to organize a community of scientists working in Infectious disease proteomics? B. Potential scientific goals for this initiative 1. Selection of human proteins related to infectious diseases and immune system response based on published data using literature searches and bioinformatic analysis 2. Definition of human infectious disease-specific protein profiles (viruses, bacteria, fungi and parasites) 3. Selection of microbial proteins useful as diagnostic biomarkers. 4. Development of SRM methods for detection and quantification of human and microbial proteins 5. Generation of PeptideAtlas and SRMAtlas of selected microorganisms 6. Detection and quantification of these proteins by targeted proteomics in clinical samples 7. Detection and quantification of these proteins by affinity or antibodies based technolgies 8. Identification of novel host factors for antiviral therapeutic intervention 9. Characterization of host-pathogen protein-protein interactions 10. Building of a web page to freely-access data 11. Collaboration with other HPP Initiatives (e. g. HAI - Antibodies, HPPP – Plasma Proteins, DBI- Disease Biomarkers Initiatives, iMOP- Initiative on Model Organism Proteomes
69 HPP Early Morning Sessions - Monday, October 6, 2014
C. Contribution to J. Proteomics HUPO 2014 special issue D. HID-HPP initiative Organization and future actions
8:40 - 8:50 am Discovery and Validation of Biomarkers to Guide Clinical Management of Pneumonia; Climent Casals-Pascual, University of Oxford, UK
8:50 - 9:00 am Label-Free Proteomic Analysis of Environmental Acidification-Influenced Streptococcus Secretome Reveals a Novel Acid-Induced Protein Histidine Triad Protein A (HtpA) Involved in Necrotizing fasciitis Pyogenes; Pao-Chi Liao, National Cheng Kung University, Taiwan
9:00 - 9:10 am Phosphoproteomic Characterization of Influenza A Virus Infected Human Primary Macrophages; Tuula Nyman, Institute of Biotechnology, Finland
9:10 - 9:20 am Open Discussion
EyeOme The EyeOME: A View on the Proteomics Side of Vision Organizer: Richard Semba, Marius Ueffing, and Hyewon Chung Room I
In this session, eight speakers will present the current state-of-the-art of proteomic investigations of the eye. Tear, aqueous, vitreous, and serum sampling offers great potential for identifying bio- logical pathways leading to eye disease. A comprehensive catalogue of eye proteins should pro- vide a solid basis for proteomic studies of the eye. Animal models help increase the understanding of uveitis and diabetic macular edema. Proteomics provides new insight into major causes of blindness and visual disability such as glaucoma, retinal vascular disease, diabetic retinopathy, and age-related macular degeneration.
8:00 - 8:10 am Proteomics and Immunoproteomics Biomarker in Glaucoma; Franz Grus, Experimental Ophthalmology, Department of Ophthalmology, University Medical Center, Mainz, Germany
8:10 - 8:20 am Diagnostic Aspects of Proteomics and Metabolomics in Ophthalmology; Sascha Dammeier1; Dario Bosch1; Focke Ziemssen2; Marius Ueffing1, 1Medical Proteome Center, Institute for Ophthalmic Research, Eberhard-Karl- University Tuebingen, Tuebingen, Germany; 2Centre for Ophthalmology, University Eye-Hospital, Tuebingen, Germany
8:20 - 8:30 am The Human Eye Proteome Project - Update 2014; Richard D. Semba1; Pingbo Zhang1; Randi Turner1; Sara Ferri1; Jennifer E. Van Eyk2; Craig Dufresne3, 1Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA; 2Cedars-Sinai Medical Center, Los Angeles, CA, USA; 3Thermo Fisher Scientific, West Palm Beach, FL, USA 70 HPP Early Morning Sessions - Monday, October 6, 2014
8:30 - 8:40 am A Peculiar Translational Animal Model for Recurrent Uveitis; Cornelia A Deeg, Department of Veterinary Sciences, LMU Munich, Munich, Germany
8:40 - 8:50 am The Vitreous is an Accessible Source for Retinal and Choroidal Disease Biomarkers; Vinit B. Mahajan1, 2, Stephen H. Tsang3, Jessica M. Skeie1,2, 1Omics Laboratory, 2Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA; 3Departments of Ophthalmology, Pathology & Cell Biology, College of Physicians & Surgeons, Columbia University, New York, NY, USA
8:50 - 9:00 am Clinical Vitreous Biopsy Reveals Molecular Signature of the Retina; Jeffrey M. Sundstrom1, Alexey Nesvizhskii2, 1Department of Ophthalmology, Penn State Hershey Medical Center, Hershey, PA, USA1; 2Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA
9:00 - 9:10 am Identification of Protein Biomarkers for Retinal Thickening in Diabetic Macular Edema; Edward P. Feener1,3; Nivetha Murugesan1,3; Allen Clermont1,2,3; Ward Fickweiler1; Takeshi Kita1; Lloyd P. Aiello1,2,4; 1Joslin Diabetes Center, 2Beetham Eye Institute, Departments of 3Medicine and 4Ophthalmology, Harvard Medical School, Boston, MA, USA
9:10 - 9:20 am Exosomal Proteins in the Aqueous Humor as Novel Biomarkers in Patients with Neovascular Age-related Macular Degeneration; Hyewon Chung1; Ae Jin Choi1; Jeehyun Yoon1; Joo Young Bang2; Je-Hyun Baek2; Hyung Soon Park2; 1Department of Ophthalmology, Konkuk University School of Medicine, Seoul, Republic of Korea; 2Diatech Korea Co., Ltd., Seoul, Republic of Korea
71 HPP Early Morning Sessions - Tuesday, October 7, 2014
Human Diabetes Proteome Project (HDPP) Organizer: Martin Kussmann Room B
Diabetes prevalence has increased dramatically during recent years with rising numbers of both individuals suffering from relative (type 2 diabetes mellitus, T2DM) and absolute (type 1 diabetes mellitus, T1DM) insulin deficiency.
To slow down, eventually stop, and ideally prevent this epidemic, deeper knowledge of the pathophysiological mechanisms responsible for impaired function of the multiple organs and cell-types affected is required.
We have leveraged a worldwide constellation of expertise into the Human Diabetes Proteome Project (HDPP) initiative to generate systems-level insights into diabetes-associated cellular changes by gathering multivariate data sets over time from specialized cells and organs of healthy and diabetes-affected individuals.
The HDPP has begun not only to deliver comprehensive information on disease mechanisms but also to identify proteins and isoforms associated with diabetic pathogenesis and crucial for the development of better diagnostics, therapies and preventions.
8:00 - 8:10 am Welcome and Presentation / Introduction of the HDPP Group & Partners; Martin Kussmann, Chair, Nestle Inst. Health Science (NIHS), Lausanne, Switzerland
8:10 - 8:20 am Update on the HDPP Project and HDPP Protein List Domitille Schvartz and Jean-Charles Sanchez, Univ. Geneva, Switzerland
8:20 - 8:35 am HDPP Partner Presentation
8:35 - 8:50 am Peter Bergsten, Uppsala Univ. Sweden: Beta Cell Function HDPP Partner Presentation
8:50 - 9:05 am Loïc Dayon, NIHS: Mitochondrial Function HDPP Partner Presentation
9:05 - 9:20 am Y.A. Goo Univ. Maryland, USA / Univ. Turku, Finland: The DIPP Study Diabetes Protein Panel Project: SRM/MRM Assays (Open Discussion for all presenters and attendees)
72 HPP Early Morning Sessions - Tuesday, October 7, 2014
C-HPP, Part II: Poster Session Organizer: Gyorgy Marko-Varga Inside Poster Hall
Poster Awards (Cash Prize and Award Certificate) will be given to Total 10 Best Outstanding Poster Presenters
Each team needs to load the poster no later than 5 pm, Monday. In addition to the C-HPP, any papers related to common technology or resources can be presented.
Presentation Times: 8:00 - 8:40 am: Group A: Chromosome 1-12 and 8:40 - 9:20 am: Group B: Chr 13-22, X, Y and Related Technologies (bioinformatics, MS, Ab, reagents etc.)
HUPO Proteomics Standards Initiative (PSI) and ProteomeXchange Organizers: Eric Deutsch and Henning Hermjakob Room C
The HUPO Proteomics Standards Initiative defines community standards for data representation in proteomics to facilitate data comparison, exchange and verification. We contribute to data management and integration in all other HUPO initiatives, and have published a modular set of standards for proteomics data representation. For details of the HUPO PSI please see http://www.psidev.info
For a publication list see http://scholar.google.com/citations?user=oNoChlcAAAAJ
Based on the HUPO PSI standards, we have developed ProteomeXchange, an international consortium for efficient collection and dissemination of open proteomics data (http://www.proteomexchange.org). We will provide an overview of current PSI activities, and discuss practical aspects of data deposition in ProteomeXchange through a short tutorial and Q&A session.
73 8:00 - 8:15 am The Proteomics Standards Initiative – Introduction and Status Report Eric Deutsch, ISB Seattle
8:15 - 25 am Fine-grained modelling of molecular interactions in PSI MI XML 3.0 Henning Hermjakob, European Bioinformatics Institute, Cambridge, UK
8:25 - 8:35 am Mass Spectrometry Informatics Gerhard Mayer, MPC, Bochum, Germany
8:35 - 8:55 am Submitting Your Data to ProteomeXchange – A Mini-Tutorial Juan Antonio Vizcaino, European Bioinformatics Institute, Cambridge, UK
8:55 - 9:05 am Representing Imaging MS Data Juan Antonio Vizcaino, European Bioinformatics Institute, Cambridge, UK
9:05 - 9:20 am Open Q&A session
Antibody Proteomics Organizers: Tadashi Yamamoto and Mathias Uhlen Room D
• “ Validation of antibodies in the Human Protein Atlas project “ presented from Antibody Atlas project by Emma Lundberg, Sophia Hober, Caroline Kampf, Peter Nilsson, Jenny Ottosson Takanen, Kalle von Feilitzen and Mathias Uhlén. Science for Life Laboratory, KTH—Royal Institute of Technology, Stockholm, Sweden
• “ Antibodypedia – guiding antibody users to find the right antibody for the right application “ presented from Antibodypedia project by Tove Alm, Kalle von Feilitzen, and Mathias Uhlén. Science for Life Laboratory, KTH—Royal Institute of Technology, Stockholm, Sweden
• “AntibodyRanker” from Antibody Ranker project by Naohiko Kinoshita and Tadashi Yamamoto Biofluid Biomarker Center and Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
• “Antibodyregistry.org and the Resource Identification Initiative: identifying research resources in biomedical literature, one antibody at a time” presented from Antibodyregistry project by Anita Bandrowski. UCSD, La Jolla, CA 92093-0608, USA
• “Monoclonal antibody-based strategies for missing proteins” presented from Antibody Initiative by Ed Nice. Monash Antibody Technologies Facility, Monash University, Melbourne, Australia
• “Development and validation of a high specificity, high affinity antibodies” presented from a Antibody producing company by Simon Braschi, Gary Dillon, Weimin Zhu, Mark Bushfield, Alejandra Solache. Abcam plc, 330 Cambridge Science Park, Cambridge, CB4 0FL, UK
74 HPP Early Morning Sessions - Tuesday, October 7, 2014
Cancer II Roundtable Discussion Chaired by Joseph Kagen Organizers: Hui Zhang, Christopher Kinsinger and Edouard Nice Room E
Chair/Moderator: Jacob Kagan
Discussion Panel: Bill Hancock, Bryan Krastins, Christopher Kinsinger, Connie Jimenez, Daniel Chan, Edouard Nice, Henry Rodriguez, Hui Zhang, Jacob Kagan, Joshua LaBaer, Josip Blender, Mark Baker, Peter James, Robert Moritz, Ruedi Aebersold, Shoba Ranganathan, Sam Hanash, Zhen Zhang
Key Discussion Points
• Mining the existing datasets and databases • Dissemination of data and resources: generation and/or linking of appropriate websites • Generation of a directory of key players, skills, cancer targets, and available assays • Key persons to take responsibilities • Prioritization of targets in the top 5 cancers • Use of animal models • Understand the normal/personalized medicine
Glycoproteomics / HGPI Organizer: Hisashi Narimatsu Room F
Through the past three pilot studies, the Human Disease Glycomics/Proteome Initiative (HGPI) had tried an evaluation and standardization of glycomic technologies for discovery and application of disease-related glycome. To establish the glycomic technologies, there are many technical prob- lems even now. However, disease/biology-driven glycomic studies should make solid progress into the analyses of glyco-conjugates such as glycoproteins or glycopeptides rather than released glycans. This research direction was proposed and agreed by many committee members at the last two HGPI sessions in the HUPO annual meetings at Boston and Yokohama.
In this session, we would like to discuss on the researches generating the large-scale knowledge on glycomes, glycosylation site maps, and recent hot technologies on site-specific glycomics, as well as the construction of database for the resultant huge resources.
75 HPP Early Morning Sessions - Tuesday, October 7, 2014
Tentative Speakers:
• Novel Protocol for Preparation and nLC-MS/MS Characterization of Proteoglycan Linkage Region Glycopeptides of Human Plasma, Urine and Cerebrospinal Fluid Samples; Goran Larson; Institute of Biomedicine, University of Gothenburg;
• Mass Spectrometry-Based Novel Techniques and Methods for N-Glycomics; Haojie Lu, Ying Zhang, Yan Cai, Jing Jiao and Pengyuan Yang; Dept of Chemistry, Institutes of Biomedical Sciences, Fudan University
• Construction of the Standard Method for Mouse Tissue Glycome Mapping in HUPO BD-GPP Initiative; Atsushi Kuno1, Jun Iwaki1, Maki Yoshida1, Atsushi Matsuda1, Takashi Sato1, Yoko Itakura2, Masashi Toyoda2, Binbin Tan3, Sheng-Ce Tao3, Yan Zhang3, Hiroyuki Kaji1, Hisashi Narimatsu1; 1Glycomedicine Technology Research Center, National Institute of Advanced Industrial Science and Technology; 2Department of Vascular Medicine, Tokyo Metropolitan Institute of Gerontology; 3Ministry of Education, Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
• Development and Application of a Method for the Glycopeptide-Based Site-Specific Glycomic Analysis; Hiroyuki Kaji, Azusa Tomioka, Erika Noro, Maki Sogabe, Takashi Sato, Toshihide Shikanai, Hisashi Narimatsu; Glycomedicine Technology Research Center, National Institute of Advanced Industrial Science and Technology
Human Brain Project Organizers: Lea T. Grinberg, Young-Mok Park, Fouzi El Magraoui, Helmut E. Meyer Room G
8:00 - 8:02 am Welcome Address; Helmut E. Meyer
8:02 - 8:14 am Bridging Old and New Anatomo-Proteomic Characterization of Human Brain Subcortical Nuclei; Enrique Santamaría Martínez
8:14 - 8:26 am Proteomic Characterization of Neuromelanin Granules; Katrin Marcus
8:26 - 8:38 am Autoantibodies as Disease Markers in ALS and Other Neurodegenerative Diseases; Caroline May
8:38 - 8:50 am Molecular Predictive Diagnosis of Preclinical Alzheimer’s Disease: On the Way Towards the Development of Future Preventive Treatment Options; Jens Wiltfang
8:50 - 9:02 am Discovery of Regulated Brain Proteins in Mouse Multiple Sclerosis Models and the Presence of Their Homologues in Human CSF; Frode Berven
9:02 - 9:20 am Open Discussion 76 HPP Early Morning Sessions - Tuesday, October 7, 2014
Proteome Biology of Stem Cells Organizers: Javier Muñoz, Jeroen Krijgsveld, Albert Heck Room H
8:00 - 8:20 am Reprogramming in vivo Produces Teratomas and iPS Cells with Totipotency Features; Maria Abad (CNIO, Madrid, Spain)
8:20 - 8:40 am Proteome profiling of human healthy and tumor colon organoids; Alba Cristobal, Marc van de Wetering, Henk van den Toorn, Hans Clevers, Albert Heck, Shabaz Mohammed (Biomolecular Mass Spectrometry and Proteomics Group, Utrecht, The Netherlands)
8:40 - 9:00 am Characterisation of a novel spontaneous model of epithelial to mesenchymal transition using a primary prostate cancer cell line using quantitative label-free proteomics (SWATH™); David Boocock, Clare Coveney, Naomi Dunning-Foreman, Jayakumar Vadakekolathu, Matthew Nicklin, Graham Hickman, Graham Pockley, Sibylle Heidelberger, Thomas Knapman, Robert Rees (John van Geest Cancer Research Centre, Nottingham, UK)
9:00 - 9:20 am Dynamics of locus-specific chromatin composition in stem cells; Mahmoud-Reza Rafiee and Jeroen Krijgsveld (European Molecular Biology Laborator, Heidelberg, Germany)
Biobanking and Pre-Anlytical Sample Assessment Organizer: Andrea Urbani Room I
8:00 - 8:15 am Opening and General Concepts; Andrea Urbani
8:15 - 8:35 am Biobanking Workflow for Proteomics Investigation; Gyorgy Marko Varga
8:35 - 8:55 am Intergating and Developing Quality Controls in System Biology; Garry Corthals
8:55 - 9:00 am Direct Analytical Sample Quality Assessment (DASQ) for Biomarker Investigation: Qualifying CSF Samples; Viviana Greco
9:00 - 9:15 am Round Table Discussion for the Preparation of Seeding Initiative on Standardization and Biobanking
9:15 - 9:20 am Closing; Andrea Urbani
77 HPP Early Morning Sessions - Wednesday, October 8, 2014
Respiratory Diseases Organizer: Rainier Bischoff Room B
This workshop has the goal to establish Respiratory Disease as a new area in the B/D-HPP program of HUPO.
8:00 - 8:10 am The Need to Establish a Respiratory Disease Area as Part of the B/D-HPP Program Rainer Bischoff, University of Groningen, Netherlands
8:10 - 8:20 am What We Can Learn from Proteogenomics Approaches Peter Horvatovich, University of Groningen, Netherlands
8:20 - 8:30 am Biobanking Gyorgy Marko-Varga, Tom Fehniger, Lund University, Sweden
8:30 - 8:40 am The Role of Glycans in COPD Naoyuki Taniguchi, RIKEN and RIKEN-Max Planck Joint Research Center, Japan
8:40 - 8:50 am The Clinical Need for Proteomics Research in Respiratory Disease Xiangdong Wang Fudan University, Shanghai, China
8:50 - 9:20 am Panel Discussion: Consortium Building, Sub-Topics (e.g. asthma, COPD), Funding Opportunities / Strategies
78 HPP Early Morning Sessions - Wednesday, October 8, 2014
C-HPP, Part III: Principal Investigators Council Organizer: Young-Ki Paik Room C
This meeting is intended for Principal Investigator Council members and guests (by invitation).
1. Approval of new Chr 16 PI
2. A New Strategy for Stimulating C-HPP Activities.
3. Election of the C-HPP EC member-at-large
4. 2015 C-HPP workshop plans
5. 2015 JPR Special Issue on thematic topics with publication timing may possibly be explored.
6. Organization Matters
Looking to the Future: The Cardiovascular Initiative Organizers: Jennifer Van Eyk, Catherine Costello, Peipei Ping, Vidya Venkatraman, Maggie Lam Room D
Session Chair: Peipei Ping, PhD
Popular Proteins in the Heart 8:00 - 8:10 am Jennifer Van Eyk, PhD; Peipei Ping, PhD; Vidya Venkatraman, PhD; Maggie Lam, PhD Cedars-Sinai Medical Center; University of California Los Angeles
Perspectives and Updates on Proteomics in Cardiovascular Sciences 8:10 - 8:20 am Moving to Populations in Biomarkers; Manuel Mayr, MD, PhD, King’s College, London
8:20 - 8:30 am Dynamic Regulations of the Cardiac Proteome; Maggie Lam, PhD, University of California, Los Angeles
8:30 - 8:40 am PTM in Heart Disease - Which Are Your Favorite?; Melanie White, PhD, The University of Sydney, Australia
8:40 - 8:50 am Large-Scale Pre-Clinical/Clinical Profiling; Jun Qu, PhD, University at Buffalo
8:50 - 9:00 am The Complexity of Oxidative Modifications; Catherine Costello, PhD, Boston University School of Medicine
9:00 - 9:20 am Panel Discussion 79 HPP Early Morning Sessions - Wednesday, October 8, 2014
CompMS - HUPO Computational Mass Spectrometry Initiative Organizers: Henning Hermjakob Room E
CompMS is a new, joint initiative of HUPO and the International Society for Computational Biol- ogy (ISCB). It promotes the efficient, high quality analysis of mass spectrometry data through dissemination and training in existing approaches and coordination of new, innovative approach- es. The CompMS initiative aims to exploit synergies between different application domains, in particular proteomics and metabolomics. We aim to
• build a community of scientists working in computational mass spectrometry • integrate experimental and theoretical research • bridge the gaps between proteomics, metabolomics, and other MS-driven fields
For more information on CompMS please see http://compMS.org. This will be the constitutive meeting of CompMS as a HUPO initiative, and will provide an oppor- tunity for all attendees to engage with the initiative and its future activities.
8:00 - 8:10 am Introduction to the Computational Mass Spectrometry Initiative, Oliver Kohlbacher (U Tuebingen)
8:10 - 8:30 am Computational Challenges in Spatial Mass Spectrometry, Laurent Gatto (U Cambridge)
8:30 - 8:50 am Spatial Metabolomics Using Imaging Mass Spectrometry, Theodore Alexandrov (U Bremen / EMBL Heidelberg)
8:50 - 9:20 am Open Business Meeting of the HUPO Initiative for Computational Mass Spectrometry
80 HPP Early Morning Sessions - Wednesday, October 8, 2014
Mitochondria Organizers: Andrea Urbani Room G
8:00 - 8:05 am Opening, Andrea Urbani
8:05 - 8:17 am Characterization, Design, and Function of the Mitochondrial Proteome: From Organs to Organisms, Peipei Ping
8:17 - 8:29 am Decoding the Mitochondrial Interaction Landscape in Neurodegenerative Diseases, Mohan Babu
8:29 - 8:41 am The Mitochondrial Proteome from the Human Protein Atlas Perspective, Emma Lundberg
8:41 - 8:53 am Mitochondrial Proteomics of Cellular Models of Parkinson’s Disease Pathogenesis, Mauro Fasano
8:53 - 9:05 am Bacterial Resistance and Host Mitochondria Rearrangements, Alessio Soggiu
9:05 - 9:17 am Investigating Mitochondria Proteome in Fatigue Syndrome, Federica Ciregia
9:17 - 9:20 am Wrap up
Protein Aggregation Diseases B/D HPP Working Group Organizers: Paola Picotti Room H
8:00 - 8:10 am Introduction
8:10 - 8:20 am Amyloidoses: fatal diseases caused by Misfolded Proteins; Bouke Hazenberg (University of Groningen, Netherlands)
8:20 - 8:30 am Targeted MS Assays for the Clinical Diagnosis and Subtyping of Systemic Amyloidoses in Subcutaneous Fat Aspirates; Paul Boersema (ETH Zurich, Switzerland)
8:30 - 8:40 am Proteomics in the Understanding and Management of Systemic Amyloidoses: The Pavia Experience; Giampaolo Merlini (University of Pavia, Italy)
8:40 - 8:50 am Disease developments in Parkinson and Malignant Melanoma; Melinda Rezeli (Lund University)
8:50 - 9:00 am Towards MS-Based Conformational (Bio)Markers?; Paola Picotti (ETH Zurich, Switzerland)
9:00 - 9:20 am Wrap-up 81 HPP Early Morning Sessions - Wednesday, October 8, 2014
PediOme Pediatric Proteomics Initiative (PediOme): Exploring Child Health with Proteomics Organizers: Allen Everett and Vera Ignjatovic Room I
Overview of the project will be followed by these talks:
• Differences in Platelet Proteome and Secretome between Children and Adults: The Role in Protection from Thrombosis and Cardiovascular Disease. - Vera Ignjatovic
• The Regenerative Abilities of Resident Cardiac Stem Cell Depends on Secreted Paracrine Factors - Sunjay Kushal
• Monitoring the Status of Infants Being on Nursing in Incubators by Urine Proteome Analysis. - Alexey Kononikhin
• Urine Proteomics for the Discovery of Non-Invasive Diagnostic Biomarkers for Pediatric Diseases. - Hanno Steen
• Omics in Nutrition and Its Perspectives for Pediatrics Research and Healthcare - Martin Kussmann
82 INDUSTRY WORKSHOP PROGRAMS
83 Industry Workshop Programs
DAY TIME COMPANY ROOM SESSION
13:00 - 14:15 BRUKER ROOM B LUNCH SYMPOSIUM MONDAY 6 OCTOBER 2014 13:00 - 14:15 WATERS ROOM D LUNCH SYMPOSIUM
13:00 - 14:15 ABSciex ROOM B LUNCH SYMPOSIUM
THERMO TUESDAY 13:00 - 14:15 ROOM C LUNCH SYMPOSIUM 7 OCTOBER FISHER 2014
18:45 - 20:00 AGILENT ROOM D MEETING OF THE MINDS
85 86 Industry Workshop Programs
13:00 - 14:15 MONDAY 6 OCTOBER 2014
Room B Bruker Daltonic GmbH Lunch Symposium
We are pleased to invite you to the Bruker sponsored lunch seminar on Monday, October 6th, Room B, 1.00-2.15 p.m.
“Qualitative and quantitative proteomics on the Impact Q-TOF platform” Dr. Stephanie Kaspar Application Development Scientist, Bruker Daltonics, Germany
“Evaluation of quantitative proteomics performance and robustness on a benchtop UHR-QTOF platform”
Professor Dr. Alain Van Dorsselaer LSMBO, Strasbourg
“Modern time of flight instrumentation fullfilling the needs of shotgun proteomics”
Scarlet Beck Research Department Proteomics and Signal Transduction, MPI Munich
87 88 Industry Workshop Programs
13:00 - 14:15 MONDAY 6 OCTOBER 2014
Room D Waters Corporation Lunch Symposium Developments in Progenesis QI for proteomics Dr. Robert Tonge Waters Corporation, Wilmslow, UK
Proteomic analyses pose a massive analytical challenge in which thousands of structurally similar analytes are distributed over a wide dynamic range. Our unique approach and analytical strategy combines three orthogonal techniques to separate, characterise and quantify the components of very complex biological samples. We integrate Ultra Performance Liquid Chromatography (UPLC) or Ultra Performance Convergence Chromatography (UPC2), Travelling Wave Ion Mobility Separation (TW-IMS) and high resolution Time-Of-Flight (TOF) mass spectrometry to enable High Definition Transomics Analysis. The combination of complimentary orthogonal methods allows the total Peak Capacity of the analytical system to be increased by an order of magnitude compared to the conventional methodologies. Endogenous metabolite/lipid and protein profiling are performed with highly specific analytical systems where analytes are fully separated before identification and quantification, minimising the potential misleading effects of contaminant data. Alongside instrumentation, software is increasingly important to realize the value in feature-rich experimental data. Progenesis QI for proteomics software, co-developed with Nonlinear Dynamics, delivers highly intuitive, flexible, common workflows for bottom-up protein profiling with comprehensive data visualizations to facilitate robust transomics studies on all scales. We will present the latest development and applications of Progenesis for proteomic studies.
Using Skyline to extend targeted proteomics to IMS-TOF Dr. Michael MacCoss University of Washington, Seattle, USA
Skyline is a freely-available Windows client application for building Selected Reaction Monitoring (SRM) / Multiple Reaction Monitoring (MRM), Parallel Reaction Monitoring (PRM - Targeted MS/MS), Data Independent Acquisition and targeted DDA with MS1 quantitative methods and analyzing the resulting mass spectrometer data. It aims to employ cutting-edge technologies for creating and iteratively refining targeted methods for large-scale proteomics studies. This presentation will focus upon the development of Skyline for targeted proteomics experiments using the unique ion mobility functionality contained within the Waters Synapt systems.
89 90 Industry Workshop Programs
13:00 - 14:15 TUESDAY 7 OCTOBER 2014
Room B AB SCIEX Lunch Symposium
SOLUTIONS FOR NEXT GENERATION PROTEOMICS AND QUANTITATIVE BIOLOGY
Extending the Power of SWATH™ Acquisition – Advances in Data Acquisition and Processing
Christie Hunter AB SCIEX
Bioinformatics Solutions for the Next Generation of Quantitative Omics
Anne-Claude Gingras Samuel Lunenfeld Research Institute, Mount Sinai Hospital
*Lunch included
91 92 Industry Workshop Programs
13:00 - 14:15 TUESDAY 7 OCTOBER 2014
Room B Thermo Fisher Scientific Lunch Symposium
Multiplexed quantitation: The need for moredata to drive understanding of functional biology and disease”.
Introduction: Julian Saba
DIA analyses – Confirmed title: ”Novel DIA methods for pathways analysis”. Michael Blank, Thermo Fisher Scientific
NTAILS workflow – Confirmed title: “TMT10 plex analysis of the N-terminome by TAILS in NFkbeta stimulation”
Chris Overall, Canada Research Chair, The University of British Columbia, Canada
93 94 Industry Workshop Programs
18:15 - 20:00 TUESDAY 7 OCTOBER 2014
Room D Agilent Technologies - Meeting of the Minds
Continuing what has become a tradition at HUPO meetings, Agilent Technologies is pleased to host the “Meeting of the Minds” on 7th October. This event allows young scientists to meet with established leaders in Proteomics in a social environment.
Register in advance to secure your ticket www.agilent.com/chem/hupo2014
95 96 Odd numbers:POSTERS Monday 6, 2014 Even numbers: Tuesday 6, 2014 Odd and Even numbers: Wednesday 7, 2014
97 01 - CANCER PROTEOMICS
P-1 OVEREXPRESSION OF AVß6 INTEGRIN ALTERS THE COLORECTAL CANCER CELL PROTEOME IN FAVOR OF ELEVATED PROLIFERATION AND A SWITCHING IN CELLULAR ADHESION THAT INCREASES INVASION David Cantor1, Iveta Slapetova2, Alison Kan1, Leon McQuade3, Mark Baker1 1 Macquarie University 2 University of New South Wales 3 Australian Proteome Analysis Facility
P-2 CIRCULATING PROTEOLYTIC PRODUCTS OF TUMOR-RESIDENT ENZYME AS POTENTIAL BIOMARKERS FOR EARLY DETECTION OF BREAST CANCER Tony Hu Houston Methodist Research Institute, Weill Cornell Medical College of Cornell University
P-3 CHARACTERISATION OF THE UPAR•AVß6 INTERACTION IN COLORECTAL CANCER CELL LINES Seone Ahn1, Samyuktha Anand2, Abidali Mohamedali1, Harish Cheruku1, Sowmya Gopichandran2, David Cantor1, Shoba Ranganathan2, Ronald Frank3, Edouard Nice4, Mark Baker1 1 Australian School of Advanced Medicine, Faculty of Human Sciences, Macquarie University, NSW 2109, Australia 2 Department of Chemistry and Biomolecular Sciences, Macquarie University, NSW 2109, Australia 3 Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffen Strasse 738124 Braunschweig, Germany 4 Department of Biochemistry and Molecular Biology, Monash University, VIC, Australia, 3800
P-4 MEMBRANE PROTEOME ANALYSIS OF TGFB STIMULATED COLORECTAL CANCER CELL LINES Harish Cheruku, Sock Hwee Tan, Charlie Ahn, Abidali Mohamedali, David Cantor, Mark Baker Australian School of Advanced Medicine, Faculty of Human Science, Macquarie University, Sydney, NSW 2109, Australia Department of Chemistry and Biomolecular Sciences, Faculty of Science, Macquarie University, Sydney, NSW 2109, Australia
P-5 MAPPING THE FUNCTIONAL PROTEIN COMMUNICATION BETWEEN DIFFERENT CELL TYPES IN THE TUMOR MICROENVIRONMENT OF PANCREATIC CANCER Mohamed Saiel Saeed Alhamdani, Jörg D Hoheisel DKFZ/Functional Genome Analysis
98 P-6 THE B6 INTEGRIN ENHANCES PLASMINOGEN AND LATENT-TRANSFORMING GROWTH FACTOR-B ACTIVATION, PROMOTING THE METASTATIC PHENOTYPE IN COLORECTAL CANCER CELLS David Cantor1, Harish Cheruku1, Seong Beom Ahn1, Michael Crouch2, Mark Baker1 1 Macquarie University 2TGR BioSciences, Australia
P-7 IMPROVING THE CHROMATOGRAPHIC SEPARATION OF DMB-LABELED SIALIC ACIDS FOR THE COMPARISON OF BIOSIMILARS TO REFERENCE MATERIALS Xiaoning Lu, Isil Yasa, Ben Cutak, Kevin Ray, David Bell Sigma-Aldrich
P-8 A NOVEL NEGATIVE ENRICHMENT METHOD FOR PROTEOME SCALE C-TERMINAL PEPTIDES ANALYSIS AND ITS APPLICATIONS Yichu Shan1, Lingfan Chen1,2, Lihua Zhang1, Yukui Zhang1 1 Dalian Institute Of Chemical Physics,Dalian,China 2 University of Chinese Academy of Sciences, Beijing,China
P-9 IDENTIFICATION OF SIGNALING PATHWAYS ASSOCIATED WITH PROSTATE CANCER RADIORESISTANCE USING THE LABEL-FREE LC-MS/MS APPROACH Lei Chang1,2, Valerie Wasinger3, Peter Graham1,2, Jingli Hao1,2, Jie Ni1,2, Julia Beretov1,2, Joseph Bucci1,2, Paul Cozzi2,4 John Kearsley1,2 Yong Li1,2 1 Cancer Care Centre and Prostate Cancer Institute, St George Hospital, Kogarah NSW 2217, Australia 2 St George and Sutherland Clinical School, Faculty of Medicine, UNSW, Kensington, NSW 2052, Australia 3 Bioanalytical Mass Spectrometry facility, Mark Wainwright Analytical centre, UNSW, Kensington, NSW 2052, Australia 4 Department of Surgery, St George Hospital, Kogarah, NSW 2217, Australia
P-10 QUANTITATIVE PROTEOMIC PROFILING IDENTIFIES DPYSL3 AS PANCREATIC DUCTAL ADENOCARCINOMA-ASSOCIATED MOLECULE THAT REGULATES CELL ADHESION AND MIGRATION BY STABILIZATION OF FOCAL ADHESION COMPLEX Kiyoshi Yanagisawa, Takashi Takahashi Division of Molecular Carcinogenesis, Nagoya University Graduate School of Medicine
P-11 HYPOTHESIS DRIVING PROTEOMIC STUDY ON THE EFFECT OF DIETARY UNSATURATED FATTY ACIDS ON PROSTATE CANCER Mu Wang, Heng Zhao, Beth Pflug, Xianyin Lai Indiana University
99 P-12 PROTEOMICS IDENTIFIED OVEREXPRESSION OF SET ONCOGENE PRODUCT AND POSSIBLE THERAPEUTIC UTILITY OF PROTEIN PHOSPHATASE 2A IN ALVEOLAR SOFT PART SARCOMA Daisuke Kubota1, Akihiko Yoshida2, Akira Kawai1, Tadashi Kondo3 1 Division of Musculoskeletal Oncology, National Cancer Center Hospital 2 Pathology and Clinical Laboratory Division, National Cancer Center Hospital 3 Division of Pharmacoproteomics, National Cancer Center Research Institute
P-13 DISCRIMINATION BETWEEN PATIENTS WITH VARIOUS STAGES OF CERVIX CARCINOMA BY SERUM ANALYSIS OF DIFFERENTIALLY EXPRESSED HEAT SHOCK PROTEIN 90 FOUND BY LASER MICRODISSECTION Rainer Bischoff1, Coskun Güzel2, Nathalia Govorukhina1, Klaske ten Hoor3, Lennard Dekker2, Harry Hollema3, Harry Klip3, Ate van der Zee3 Alexander Boichenko1 Theo Luider2 1 University of Groningen 2 Erasmus MC Rotterdam 3 University Medical Center Groningen
P-14 SNAIL11 SUPPRESSES DIFFERENTIATION IN 3T3-L1 FIBROBLAST AND MMSC BY REPRESSION OF NOVEL SNAIL-MODULATED TRANSCRIPTION FACTORS Alberto Peláez Garcia1, Rodrigo Barderas1, Raquel Batlle2, Ruben Alvaro Bartolomé1, Maria Lopez-Lucendo1, Marta Mendes1, Sofia Torres1, Jean Charles Sanchez3 Antonio Garcia de Herreros2 Jose Ignacio Casal1 1Centro De Investigaciones Biologicas 2IMIM-Hospital del Mar 3University of Geneva (CMU, UNIGE)
P-15 PROTEOMIC PROFILING OF AN INDUCIBLE MODEL OF ACUTE MYELOID LEUKAEMIA REVEALS NOVEL INSIGHTS INTO LEUKAEMOGENESIS. Jarrod Sandow, Gabriela Brumatti, Giuseppe Infusini, Andrew Webb, Paul Ekert The Walter And Eliza Hall Institute
P-16 MEMBRANE PROTEINS ASSOCIATED WITH INVADOPODIA STRUCTURES IN GLIOBLASTOMA MULTIFORME Duthika M. Mallawaaratchy1, Kerrie L. McDonald2, Erin K. Sykes1, Michael E. Buckland3, 4, Richard I. Christopherson1, Kimberley L. Kaufman1, 4 1 University Of Sydney, Sydney, NSW, Australia 2 University of New South Wales, Sydney, NSW, Australia 3 Royal Prince Alfred Hospital, Camperdown, NSW, Australia 4 Brain and Mind Research Institute, Camperdown, NSW, Australia
P-17 DIFFERENTIAL DIAGNOSIS OF PANCREATIC CYSTS USING MASS SPECTROMETRY- BASED APPROACH Jisook Park, Hwan Sic Yun, Kwang Hyuck Lee, Kyu TaeK Lee, Jong Kyun Lee, Soo Youn Lee Samsung Medical Center
100 P-18 PHOSPHOPROTEOMICS REVEALED TRPV4 CALCIUM PERMEABLE CHANNEL TO BE A NOVEL EFFECTOR OF BREAST CANCER METASTASIS Yoon Pin Lim1, Lee Yee Choong1, Sandy Lee1, Naing Naing Mon1, Ssu Yi Lu1, Brian Druker2, Jean Paul Thiery1, Patrick Tan3 Chwee Teck Lim4 Christian Harteneck5 1 National University Of Singapore 2 Oregon Health and Science University 3 Duke-NUS Medical Graduate School 4 Mechanoniology Institute 5Eberhard-Karls-Universitát
P-19 ANALYSIS OF MEMBRANE PROTEIN EXPRESSION PATTERNS FOR CELLS CULTURED USING CANCER-TISSUE ORIGINATED SPHEROIDS Haruhiko Kamada1, Shintaro Taki1, Masaki Inoue1, Kazuya Nagano1, Yohei Mukai1, Yasuo Yoshioka3, Kazuma Higashisaka3, Yasuo Tsutsumi3 Shin-ichi Tsunoda1 1 Lab Biopharmaceutical Res, Natl Inst Biomedical Innovation 2 MEI Center, Osaka University 3 Lab Toxicol Safety Sci, Osaka University
P-20 PROTEOMIC ANALYSIS REVEALS FAM120A AS A KEY REGULATOR OF IL13-TRIGGERED LIVER METASTASIS IN COLORECTAL CANCER Ruben A Bartolome1, Irene Garcia-Palmero1, Sofia Torres1, Maria Lopez-Lucendo1, Irina V Balyasnikova2, J Ignacio Casal1 1 Centro De Investigaciones Biologicas (CSIC), Madrid, Spain 2 University of Chicago, Chicago, Illinois, USA
P-21 DATA-INDEPENDENT MSE WITH ION MOBILITY IDENTIFIES A GPX4 AS A NEW TARGET FOR ANTI-CANCER DRUGS Lewis M. Brown1, Rohitha SriRamaratnam1, Wan Seok Yang1, Matthew E. Welsch1, Kenichi Shimada1, Clary B. Clish2, Albert W. W. Girotti3, Virginia W. Cornish1 Stuart L. Schreiber2 Brent R. Stockwell1 1 Columbia University, New York, NY 2 Broad Institute of Harvard and MIT 3 Medical College of Wisconsin, Milwaukee, WI
P-22 SHOTGUN PROTEOMICS RECOGNIZES CELL LINES USING EXOME DATA: NCI-60 PANEL CASE STUDY Maria A. Vlasova1, Dmitry A. Karpov1, Mark V. Ivanov2, Mikhail A. Pyatnitskiy1, Vassily N. Lazarev3, Victor G. Zgoda1, Anna A. Lobas2, Alexander A. Archakov1, Mikhail V. Gorshkov2 Sergei A. Moshkovskii1 1 Orekhovich Institute Of Biomedical Chemistry, Moscow, Russia 2 Institute for Energy Problems of Chemical Physics, RAS, Moscow, Russia 3 Institute of PhysicP-Chemical Medicine, Moscow, Russia
101 P-23 DEVELOPMENT OF PROTEOMIC BASED DIAGNOSTIC BIOMARKERS FOR EARLY DETECTION OF LIVER CANCERS Shabnam Malik, Deepshikha Pande Katare, S.K. Jain Jamia Hamdard Amity Institute of Biotechnology, Amity University, Noida
P-24 MRM VALIDATION OF TARGETED NONGLYCOSYLATED PEPTIDES IN UNDEPLETED HUMAN PLASMA USING SIMPLE SAMPLE PREPARATION METHOD Ju Yeon Lee1,2, Jin Young Kim1, Mi Hee Cheon1,3, Gun Wook Park 1,3, Yeong Hee Ahn 1, Young Hye Kim1, Myeong Hee Moon2, Jong Shin Yoo1,3 1 Korea Basic Science Institute, P-chang Campus, Chungcheongbukdo, Korea 2 Department of Chemistry, Yonsei Univesity, Seoul, Korea 3 Graduate School of Analytical Science and Technology, Deajeon, Korea
P-25 DIFFUSE LARGE B CELL TYPE NON HODGKIN LYMPHOMA OF PANCREAS IN A PATIENT WITH MS; A CASE REPORT FROM IRAN Pooria Ghadiri1, Alireza Nikseresht2, Maryam Sharifian3, Nazila hassanabadi4, amirhossein sharifian5, Abbas mohammadi4, Alireza Setarehaseman4 1 Department of Neurology, Student Research committee Shiraz university of Medical Sciences 2 Department of Neurology ,Faculty of medicine, Shiraz university of Medical Sciences. 3 Department of Neurology, Resident of neurology, Shiraz university of Medical Sciences 4 Department of Neurology, Student Research committee Shiraz university of Medical Sciences 5 Department of Neurology Student Research committee, Jahrom university of Medical Sciences
P-26 LATE ONSET MULTIPLE SCLEROSIS IN SOUTHERN IRAN Alireza Setarehaseman1, Alireza Nikseresht2, Sadegh Izadi2, Pooria Ghadiri3, amirhossein sharifian4, Abbas Mohammadi4, Maryam Sharifian5, Nazila Hassanabadi1 1 Faculty of medicine, Student Research committee Shiraz university of Medical Sciences 2 Department of Neurology, Faculty of medicine, Shiraz university of Medical Sciences. 3 Department of Neurology Student Research committee Shiraz university of Medical Sciences 4 Department of Neurology Student Research committee, Jahrom university of Medical Sciences 5 Department of Neurology, Resident of neurology, Shiraz university of Medical Sciences
P-27 ALPHA 1-ANTITRYPSIN AND ALPHA 2HS-GLYCOPROTEIN, TWO TUMOR-ASSOCIATED ANTIGENS (TAA) DETECTED IN MEXICAN PATIENTS WITH EARLY-STAGE BREAST CANCER Rodolfo Hernández-Gutiérrez1, Adriana Aguilar-Lemarroy2, Luis Jave-Suarez2, Abel Gutiérrez-Ortega1 1 CIATEJ, A. C. Av. Normalistas 800, Colinas de la Normal, Guadalajara 2 CIBP-IMSS. Sierra Mojada #800 Col. Independencia, Guadalajara, Jalisco. México
102 P-28 DIAGNOSTIC PROTEIN BIOMARKERS OF WELL-DIFFERENTIATED THYROID MALIGNANCIES IN THAI PATIENTS N. Monique Paricharttanakul1, Kittirat Saharat2, Daranee Chokchaichamnankit1, Phaibul Punyarit3, Chantragan Srisomsap1, Jisnuson Svasti1,2 1 Laboratory of Biochemistry, Chulabhorn Research Institute 2 Applied Biological Sciences Program, Chulabhorn Graduate Institute 3 Department of Clinical Pathology, Army Institute of Pathology, Phramongkutklao Medical Center
P-29 UNDERSTANDING LAPATINIB ACTION BY CHEMICAL – AND PHOSPHOPROTEOMICS Benjamin Ruprecht1, Bernhard Kuster1, Simone Lemeer1,2 1 Chair of Proteomics and Bioanalytics, Technische Universitaet Muenchen, Freising, Germany 2 Biomolecular Mass Spectrometry and Proteomics, Utrecht University, the Netherlands
P-30 UNCOVERING AQUIRED RESISTANCE MECHANISMS TO EGFR-SPECIFIC KINASE INHIBITORS USING CHEMICAL PROTEOMICS Heiner Koch1,2,3, Estela Del Castillo Busto1, Karl Kramer1, Guillaume Medard1, Bernhard Kuster1,2,3,4 1 Chair of Proteomics and Bioanalytics, Technische Universität München, Freising, Bavaria, Germany 2 German Cancer Consortium (DKTK), Munich, Bavaria, Germany 3 German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany 4 Center for Integrated Protein Science Munich, Munich, Bavaria, Germany
P-31 AFFINITY PROTEOMICS IN PLASMA FROM CANCER BIOBANKS Jochen Schwenk, Kimi Drobin, Sanna Byström, Burcu Ayoglu, Ulrika Qundos, Mun-Gwan Hong, Frauke Henjes, Claudia Fredolini, Peter Nilsson, Mathias Uhlen SciLifeLab, KTH - Royal Institute of Technology
P-32 A UNIQUE CELLULAR MODEL OF THE COLORECTAL ADENOMA-TP-CARCINOMA SEQUENCE REVEALS CONSISTENT SERIES OF PROGRESSION MARKERS IN TWO INDEPENDENT DIFFERENTIAL LABEL-BASED (ITRAQ-MALDI) AND LABEL-FREE (TRIPLE-TOF) MASS SPECTROMETRIC SETTINGS Stefan Müller1, Dietmar Waidelich2, Franz-Georg Hanisch1 1 Institute of Biochemistry II, Medical Faculty, University of Cologne 2 ABSciex, Darmstadt, Germany
P-33 PROTEIN BIOMARKERS FOR PROSTATE CANCER IN URINARY EXOSOME-LIKE VESICLES Tamara Sequeiros2, Cristina Chiva1, Marina Rigau2, Melania Montes2, Jaume Reventós2, Andreas Doll2, Mireia Olivan2, Eduard Sabidó1 1 University Pompeu Fabra/Centre for Genomic Regulation, Barcelona, Spain 2 Research Institute Vall d’Hebron University Hospital, Barcelona, Spain
103 P-34 IDENTIFICATION OF NOVEL TWIST1 TARGETS IN HUMAN FIBROBLASTS BY ITRAQ-BASED QUANTITATIVE PROTEOMICS. Irene Garcia-Palmero1, Sofia Torres1, Alberto Peláez-García1, María Lopez-Lucendo4, María Jesús Larriba3, Mercedes Herrera2, Alberto Muñoz3, Felix Bonilla2 J. Ignacio Casal1 1 Department of Cellular and Molecular Medicine. Centro de Investigaciones Biológicas (CIB-CSIC). 28040 Madrid, Spain 2 Oncology Department. Hospital Puerta de Hierro Majadahonda. Madrid. Spain 3 Instituto de Investigaciones Biomédicas ‘‘Alberto Sols’’ (CSIC-UAM). Madrid, Spain 4 Proteomics core facility. CIB-CSIC. Madrid. Spain
P-35 MOUSE MONOCLONAL ANTIBODIES AGAINST HUMAN URINARY PROTEIN SM-UP2IP OF SCHISTOSOMA MANSONI Daniel Boamah1,2, Irene Ayi2, Kobena Yankson3, Kwabena Bosompem2 1 Centre For Scientific Research Into Plant Medicine. 2 Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. 3 School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.
P-36 COMPREHENSIVE PROTEOMIC PROFILING OF BEVACIZUMAB-RESISTANT GLIOBLASTOMA MULTIFORME Kimberley Kaufman1, Linda Ly1, Matthew McKay2, Duthika Mallawaaratchy1, Swetlana Mactier1, Ben Crossett1, Mark Molloy2, Michael Buckland1,3 Kerrie McDonald4 Richard Christopherson1 1 University of Sydney, NSW 2006, Australia 2 Macquarie University, Sydney, NSW 2109 Australia 3 Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia 4 University of New South Wales, Sydney, 2052, Australia
P-37 MELANOMA; THE UNFOLDED PROTEIN RESPONSE AND MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 1 Erin Sykes, Swetlana Mctier, Kimberley L. Kaufman, Munther Alomari, Duthika M. Mallawaaratchy, Richard I. Christopherson University Of Sydney, Sydney, NSW, Australia
P-38 PROTEOMIC DYNAMICS IN UTERINE CERVICAL CANCER TUMORS FROM THE CANCER CELL LINES HELA AND SIHA. Sergio Encarnación-Guevara, Luis-Fernando Delgadillo-Silva, Alberto Checa-Rojas Centro de Ciencias Genómicas, Universidad Nacional Autónoma De México
104 P-39 TARGETED PROTEOMIC IMMUNOASSAYS OF CANDIDATE PLASMA BIOMARKERS FOR STAGE A-D CRC Sadia Mahboob1, Sock-Hwee Tan3, Seong B Ahn1, Harish Cheruku1, David Cantor1, Alamgir Khan2, Emma Rennel4, Shoba Ranganathan3 Ed Nice5 Mark S Baker1 1 Australian School Of Advanced Medicine. Macquarie University. NSW Australia 2 Australian Proteome Analysis Facility (APAF) NSW Australiia 3 Department of CBMS, Macquarie University NSW Australia 4 Olink BioScience, Uppsala Sweden 5 Monash University. Vic Australia
P-40 PROTEOMIC ANALYSIS OF NXS2 NEUROBLASTOMA CELL LINE TREATED WITH FASTING IN COMBINATION WITH DOXORUBICIN Danilo Marimpietri1, Andrea Petretto1, Giovanna Bianchi1, Roberto Martella1, Elvira Inglese1, Chiara Lavarello1, Valter Longo2, Vito Pistoia1 Lizzia Raffaghello1 1 Istituto Giannina Gaslini, Genoa, Italy 2 University of Southern California, Los Angeles, USA
P-41 QUANTITATIVE MS-BASED ANALYSIS OF HISTONE MODIFICATION PATTERNS AS MARKERS FOR RESPONSE TO HDAC INHIBITORS IN BREAST CANCER Roberta Noberini1, Claudia Miccolo2, Susanna Chiocca2, Saverio Minucci2, 3, Tiziana Bonaldi2 1 Italian Institute Of Technology, Milan, Italy 2 European Institute of Oncology, Milan, Italy 3 University of Milan, Milan, Italy
P-42 FFPE TISSUE PROTEOMICS: WAKING SLEEPING BEAUTY Maria Filippa Addis, Alessandro Tanca, Daniela Pagnozzi, Sergio Uzzau Porto Conte Ricerche
P-44 DIFFERENTIAL PROTEIN EXPRESSION ANALYSIS IN HEPATOBLASTOMA BY 2D-DIGE AND LABEL FREE LC-MS Mikel Azkargorta1, Carolina Armengol2, Marina Simon2, Iraide Escobés1, Felix Elortza1 1 CIC BioGUNE 2 Health Science Institute Germans Trias i Pujol Foundation (IGTP)
105 P-45 PHOSPHOPEPTIDE ENRICHMENT ON A MONOLITHIC COLUMN CONTAINING SUPERFI- CIALLY IMMOBILIZED NANO TIO2 Andreas Fichtenbaum1, Pungor András2, Nagy Zoltán2, Cernigoj Urh3, Vidic Jana3, Barut Miloš3, Mitulovic Goran4 1 Medical University Of Vienna, Austria 2 University of Debrecen, Debrecen, Hungary 3 BIA Separations d.o.o. , Ajdovšcina, Slovenia 4 Medical University of Vienna
P-46 THE IDENTIFICATION OF BIOMARKERS FOR LUNG CANCER USING PLASMA COLLECTED PROXIMAL AND DISTAL TO THE SITE OF THE TUMOUR. Michael Walker1, Phillip Crosbie1, Maria Pernemalm2, Cong Zhou1, Caroline Dive1, Anthony Whetton1 1 University Of Manchester, Manchester, UK 2 Karolinska Institutet, Stockholm, Sweden
P-47 PROTEOMICS ARGUES TOWARDS MTOR/PI3K DOMINANCE IN PEDIATRIC MEDULLOBLASTOMA TUMORS WITH 17P DELETION Athanasios Anagnostopoulos, George Tsangaris Biomedical Research Foundation Of The Academy Of Athens, Athens, Greece P-48 METHOD DEVELOPMENT FOR THE QUANTITATION OF A HUMAN URINE BIOMARKER FOR ACUTE KIDNEY INJURY USING A QTRAP® MASS SPECTROMETER Dietrich Merkel1, Christian Baumann1, Robert May2 1 Ab Sciex, Darmstadt, Germany 2 Labor Dr. Spranger und Partner, Ingolstadt, Germany
P-49 COMPARISON OF EARLY STAGES OF COLORECTAL CANCER FFPE SAMPLES BY LABEL FREE PROTEOMICS Florence Quesada-Calvo1, Marie-Alice Meuwis1, Gabriel Mazzucchelli1, Nicolas Smargiasso1, Dominique Baiwir2, Joan Somja5, Philippe Delvenne5, Malaise Michel4 De Pauw Edwin2 Edouard Louis1 1 Gastroenterology, GIGA-R,ULG, University Hospital Of Liège 2 Laboratory of mass spectrometry, dep of chemistry, GIGA-R, University of Liège 3 Proteomics facility GIGA University of Liège 4 Rheumatology, GIGA-R, ULg, University Hospital Of Liège 5 Laboratory of Pathological Anatomy and Cytology , GIGA-R, University Hospital Of Liège
P-50 DECIPHERING THE RESISTANCE MECHANISMS TO EGFR TYROSINE KINASE INHIBITORS IN NON-SMALL CELL LUNG CANCER: A QUANTITATIVE PROTEOMIC APPROACH Sylvia Lehmann1;2;3, Amandine Hurbin1;2, Michel Seve1;2;3, Sandrine Bourgoin-Voillard1;2;3 1 Univ. Grenoble Alpes, IAB, PROMETHEE Proteomic Platform, F-38000 Grenoble, France 2 INSERM, IAB, PROMETHEE Proteomic Platform, F-38000 Grenoble, France 3 CHU de Grenoble, IAB, Institut de Biologie et de Pathologie, PROMETHEE Proteomic Platform, F-38000 Grenoble, France
106 P-51 PROTEOMIC ANALYSIS OF SECRETOME AND TOTAL CELL EXTRACT FROM NORMAL AND MALIGNANT CERVICAL CELL LINES Georgia Kontostathi1, 2, Vasiliki Lygirou1, 2, Jerome Zoidakis1, Antonia Vlahou 1, Nicholas P. Anagnou 1,2, Kalliopi I. Pappa1, 2 1 Biomedical Research Foundation, Academy Of Athens, Athens, Greece 2 University of Athens School of Medicine, Athens, Greece
P-52 MULTIPLEXED MRM FOR THE VERIFICATION OF PLASMA PROTEINS BIOMARKER: APPLICATIONS TO HEPATOCELLULAR CARCINOMA DEVELOPMENT AND METASTASIS Xinwen Zhou1, Yi Wang1, Pengyuan Yang1, Yinkun Liu2 1 Institutes Of Biomedical Sciences 2 Liver Cancer Institute, Zhongshan Hospital
P-53 MASS SPECTROMETRY-GUIDED DEVELOPMENT OF A LUMINEX-BASED DIAGNOSTIC TEST FOR THE REDUCTION OF UNNECESSARY PROSTATE BIOPSIES Kathrin Endt1, Jens Goepfert2, Kerstin I Pohl2, Aurelius Omlin3, Daniel Engeler3, Silke Gillessen3, Thomas O Joos2, Ralph Schiess1 1 ProteoMediX AG, Schlieren, Switzerland 2 NMI Tuebingen, Reutlingen, Germany 3 Cantonal Hospital St. Gallen, St. Gallen, Switzerland
P-54 MS-BASED IMMUNOASSAYS FOR TRANSPORTER QUANTIFICATION IN XENOGRAFT-BASED TUMOR MODELS Helen Hammer, Bart van den Berg, Frederik Weiss, Hannes Planatscher, Thomas O. Joos, Oliver Poetz Nmi
P-55 CAN PROFILING FOR PLASMA PHOSPHORYLATION BE A USEFUL TOOL IN AIDING THE DIAGNOSIS OF ALZHEIMER’S DISEASE? Nicholas Ashton1,2, Abdul Hye1,2, Malcolm Ward3, Chantal Bazenet1,2 1 Department of Old Age Psychiatry, Institute of Psychiatry, Kings College London 2 NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation 3 Proteomics facility, Institute of Psychiatry, Kings College London
P-56 MALDI TOF/TOF DETERMINATION OF SERUM PLASMINOGEN SIALYLATION PROFILE FROM PATIENTS WITH GASTRIC PRECANCEROUS LESIONS Catarina Gomes1, Andreia Almeida2, Alexandre Ferreira2, Celso Reis1, 3, Hugo Osorio1, 3 1 Institute of Molecular Pathology and Immunology of the University of Porto - IPATIMUP, Porto, Portugal 2 Department of Chemistry, University of Aveiro, Aveiro, Portugal 3 Faculty of Medicine, University of Porto, Porto, Portugal
107 P-57 DECIPHERING ALTERED CELL SIGNALING PATHWAYS IN B- LYMPHOCYTIC CHRONIC LEUKEMIA (B-CLL) BY FUNCTIONAL PROTEOMICS APPROACHES Manuel Fuentes1, Raquel Bartolome1, Martin Perez-Andres1, Paula Diez1, Marco Gonzalez 2, Julia Almeida1, Wei Wu3, Anders Holm3 Fridtjof Lund-Johansen3 Alberto Orfao1 1 Cancer Research Center. University Of Salamanca-CSIC 2 Salamanca University Hospital. 3 Department of Immunology. Oslo University. Hospital Rikshospitalet.
P-58 KNOCKDOWN OF C-FOS SUPPRESSES THE ACTIVATION AND ECM PROTEINS PRODUCTION OF PANCREATIC STELLATE CELL Aseel Marzoq, Mohamed Alhamdani, Luzia Heidrich, Jörg Hoheisel DKFZ / Germany
P-59 PROTEIN EXPRESSION PROFILES IN B-CLL PATIENTS WITH CYTOGENETIC AND MOLECULAR ALTERACTIONS Manuel Fuentes1, Paula Diez1, Seila Lorenzo1, Wendy Nieto1, Ignacio Criado1, Marcos Gonzalez2, Julia Almeida2, Alberto Orfao1 1 Cancer Research Center. University Of Salamanca-CSIC 2 Salamanca University Hospital
P-60 OPTIMIZED NONLINEAR GRADIENTS FOR REVERSED-PHASE LIQUID CHROMATOGRAPHY IN SHOTGUN PROTEOMICS Luminita Moruz1, Peter Pichler2,3, Karl Mechtler2,4, Lukas Käll5 1 Stockholm University, Stockholm, Sweden 2 Research Institute of Molecular Pathology, Vienna, Austria 3 Christian Doppler Laboratory for Proteome Analysis, Vienna, Austria 4 Institute of Molecular Biotechnology, Vienna, Austria 5 Royal Institute Of Technology - KTH, Stockholm, Sweden
P-61 SHOTGUN PROTEOMIC ANALYSIS OF PANCREATIC CANCER STEM CELLS Jessica Brandi1, Elisa Dalla Pozza1, Ilaria Dando1, Giulia Biondani1, Victoria Elliott2, Eithne Costello2, Marta Palmieri1, Daniela Cecconi1 1 University Of Verona, Italy 2 University Of Liverpool, United Kingdom
P-62 PROTEOMIC ANALYSIS OF CONNEXIN 43 REVEALS NOVEL INTERACTORS RELATED TO OSTEOARTHRITIS Maria D. Mayan1, Raquel Gago-Fuentes1, Patricia Fernandez-Puente2,3, Paula Carpintero-Fernandez1, Jesus Mateos2,3, Francisco J. Blanco1,2,3 1 Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, Xubias de Arriba 84, 15006 A Coruña, Spain 2 Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, Xubias de Arriba 84, 15006 A Coruña, Spain 3 Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, Xubias de Arriba 84, 15006 A Coruña, Spain
108 P-63 CHARACTERISATION OF A NOVEL SPONTANEOUS MODEL OF EPITHELIAL TO MESENCHYMAL TRANSITION USING A PRIMARY PROSTATE CANCER CELL LINE USING QUANTITATIVE LABEL-FREE PROTEOMICS (SWATH™). David Boocock1, Clare Coveney1, Naomi Dunning-Foreman1, Jayakumar Vadakekolathu1, Matthew Nicklin1, Graham Hickman1, Graham Pockley1, Sibylle Heidelberger2 Thomas Knapman2, Robert Rees1 1 John Van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, UK 2 AB SCIEX, Warrington, UK
P-64 FROM DISCOVERY PROTEOMICS TO FUNCTIONAL INVESTIGATION: STUDYING ABERRANT GLYCOSYLATION IN CLL CELLS Umberto Restuccia1, Cristina Scielzo2, Federico Caligaris Cappio2, Angela Bachi1 1 FIRC Institute of Molecular Oncology Foundation, IFOM, Milano, Italy 2 Lymphoid Malignancies Unit, OSR, Milano, Italy
P-65 IDENTIFYING TARGETS SPECIFIC FOR METASTASIS VIA A WHOLISTIC STRATEGY COMBINING PROTEOMICS AND TRANSCRIPTOMICS Lisa Weilnböck, Andrea Loipetzberger, Fitz Aberger, Christian G. Huber University Of Salzburg, Department Of Molecular Biology
P-66 EVALUATION OF MODE OF ACTION AS WELL AS RESISTANCE MECHANISMS REGARDING THE NOVEL ANTICANCER RUTHENIUM COMPOUND KP1339 BY PROTEOME PROFILING Dominique Kreutz1, Michael Grössl1, Ammar Tahir1, Petra Heffeter2, Walter Berger2, Bernhard Keppler3, Christopher Gerner1 1 University Of Vienna - Institute Of Analytical Chemistry 2 Medical University of Vienna - Institute of Cancer Research 3 University Of Vienna - Institute Of Inorganic Chemistry
P-67 IN-DEPTH PROTEOME PROFILING IN CHRONIC LYMPHOCYTIC LEUKEMIA – UNRAVELING NEW TREATMENT OPTIONS Rupert Mayer1, Astrid Slany1, Andrea Bileck1, Dominique Kreutz1, Josef Schwarzmeier2, Christopher Gerner1 1 University Of Vienna - Institute Of Analytical Chemistry 2 Karl Landsteiner Society - Institute Of Bioanalytical Oncology
P-68 ASSESSMENT OF TUMOR-PROMOTING ACTIVITIES OF TUMOR-ASSOCIATED FIBROBLASTS Christopher Gerner1, Andrea Bileck1, Verena Paulitschke2, Hermine Agis3, Astrid Slany1 1 University Of Vienna - Institute Of Analytical Chemistry 2 Medical University of Vienna - Department Of Dermatology 3 Medical University of Vienna - Department Of Medicine I
109 P-69 TERMINOMICS ANALYSES OF PRIMARY CELL CULTURE SUPERNATANTS IDENTIFY A ROLE FOR ADAM17 IN EXTRACELLULAR CATHEPSIN ACTIVITY Lindsay Rogers1, Carl Blobel2, Christopher Overall1 1 Department of Oral Biological and Medical Sciences, University Of British Columbia, Vancouver, British Columbia, Canada 2 Departments of Medicine and Physiology, Biophysics and Systems Biology, Weill Medical College of Cornell University, New York, New York, USA
P-70 A COMPREHENSIVE COMPARATIVE AND SEMI-QUANTITATIVE PROTEOME OF A VERY LOW NUMBER OF NATIVE AND MATCHED EPSTEIN-BARR VIRUS- TRANSFORMED B LYMPHOCYTES INFILTRATING HUMAN MELANOMA M. Maurer1, A.C Mueller2, K. Parapatics2, W.F Pickl1, C. Wagner1, E. L. Rudashevskaya2, F. P Breitwieser2, J. Colinge2 K. Garg2 J. Griss1 K.L Bennett2 S.N. Wagner3 1 Medical University Of Vienna, Vienna, Austria 2 Center for Molecular Medicine (CeMM), Vienna, Austria 3 Medical University Of Vienna, Vienna, Austria
P-71 PROTEOME PROFILING OF HUMAN HEALTHY AND TUMOR COLON ORGANOIDS Alba Cristobal1, Marc van de Wetering2, Henk van den Toorn1, Hans Clevers2, Albert J.R. Heck1, Shabaz Mohammed3 1 Biomolecular Mass Spectrometry And Proteomics Group, Utrecht, The Netherlands 2 Hubrecht Institute, Utrecht, The Netherlands 3 Chemistry Research Laboratory, Oxford, UK
P-72 DEVELOPMENT OF TARGETED PROTEOMIC METHOD FOR POSSIBLE BIOMARKERS FOR ORAL CANCER SCREENING IN HUNGARIAN POPULATION Eva Csosz, Peter Labiscsak, Viktoria Bacsik, Adrienn Szabo, Maria Fera, Jozsef Tozser, Ildiko Marton, University Of Debrecen, Debrecen, Hungary
P-73 PRELIMINARY PROTEOMIC STUDY OF EPITHELIAL –MESENCHYMAL TRANSITION INDUCED BY TGF-B1 AND EGF IN PANCREATIC CANCER CELL LINE Gabriela N.S. Canchaya, Carolina Thomé, Camila Palma, Mariana Lopes Grassi, Vera L. Epifanio, Vitor M. Faça Departaments Of Biochemistry And Inmunolog - Ribeirao Preto Medical School - University Of Sao Paulo
P-74 ASSESSMENT OF EPITELIAL TO MESENCHYMAL TRANSISTION BY MRM Vitor Faca1,2, Camila Palma1, Daniele Albuquerque1, Mariana Grassi1, Gabriela Canchaya1, Carolina Thome1, Valeria Cerqueira Cesar1, Eduardo Brant de Oliveira1 Simone Kashima Haddad2 Dimas Covas1,2 1 Ribeirao Preto Medical School - University of Sao Paulo - Ribeirao Preto - Sao Paulo - BRAZIL 2 Center for Cell Based Therapy – Hemotherapy Center of Ribeirão Preto - Ribeirao Preto - Sao Paulo – BRAZIL
110 P-75 D3CLP: AN UNFOLDED PROTEIN RESPONSE ACTIVATOR IDENTIFIED THROUGH A PROTEOMIC APPROXIMATION. Carlos Páez, Marco Antonio Cerbón, Alfonso Lira, Rogelio Rodríguez Universidad Nacional Autónoma De México
P-76 OPTIMIZATION OF A SILAC BASED QUANTITATIVE PLATFORM FOR TUMOR TISSUE PROTEOMICS Jerome Staal, Ling San Lau, Huizhen Zhang, Yetrib Hathout, Kristy Brown, Brian Rood Children’s National Medical Center
P-77 DEVELOPMENT OF CANDIDATE BIOMARKERS FOR PANCREATIC CANCER USING MULTIPLE REACTION MONITORING Chaeeun Lee1, Jiyoung Yu1, JiYoung Park1, Mee Joo Kang2, Jin-Young Jang2, Youngsoo Kim1 1 Seoul National University College Of Medicine 2 Department of Surgery, Seoul National University Hospital 3 Departments of Biomedical Engineering & Biomedical Sciences Seoul National University College of Medicine
P-78 QUANTITATIVE PROTEOMIC ANALYSIS OF PERIPHERAL BLOOD MONONUCLEAR CELLS TO IDENTIFY NOVEL BIOMARKERS FOR PANCREATIC CARCINOMA Xiaohui Liu1,2, Wansheng Wang3, Xiaolin Wang3, Pengyuan Yang1,2 1 Institue of Biomedical Science, Fudan University, Shanghai, 200032, China 2 Department of Chemistry, Fudan University, Shanghai, 200032, China 3 Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
P-79 PROTEOMIC ANALYSIS OF SP600125-CONTROLLED TRKA-DEPENDENT TARGETS IN SK-N-MC NEUROBLASTOMA CELLS: INHIBITION OF TRKA ACTIVITY BY SP600125 Choong Won Kim, Eun Joo Jung, Hyung Chul Park, Ky Hyun Chung Gyeongsang National University
P-80 QUANTITATIVE PROTEOMIC ANALYSIS OF ACQUIRED SORAFENIB RESISTANCE OF LIVER CANCER CELLS REVEALS EXPRESSION SIGNATURES ASSOCIATED WITH METASTASIS Lu-Ping Chow, Chao-Chi Institute Of Biochemistry & Molecular Biology, National Taiwan Univ
P-81 COMPARATIVE PROTEOMIC ANALYSIS OF MALIGNANT PLEURAL MESOTHELIOMA: FOCUSING ON THE BIPHASIC SUBTYPE Laura Giusti1, Ylenia Da Valle1, Federica Ciregia1, Alessandra Bonotti2, Elena Donadio1, Rudy Foddis3, Gino Giannaccini1, Giovanni Guglielmi2 Alfonso Cristaudo2 Antonio Lucacchini1 1 Department Of Pharmacy University Of Pisa 2 Operative Unit of Occupational Medicine of the University Hospital of Pisa, Italy. 3 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy.
111 P-82 IDENTIFICATION OF MOLECULAR MARKERS OF CANCER REVERSAL AND CELL DIFFERENTIATION BY SELDI PROTEIN PROFILING Javier Marquez1,2, Narkhyun Bae3, Francisco J. Alonso1, Jose A. Campos-Sandoval1, Juan A. Segura1, Jose M. Mates1, Mercedes Martin-Rufian1 1 Dept. Molecular Biology And Biochemistry, University of Malaga 2 Proteomics Unit, Central Instrumentation Facility, University of Malaga, Campus de Teatinos, 29071 Malaga, Spain 3 Department of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, 440-746, South Korea
P-83 PROTEOMIC INVESTIGATION OF BIOMARKERS USING HUMAN PLASMA AND SERUM SAMPLES FOR EARLY BREAST CANCER DIAGNOSIS. Julia Beretov1,2,3, Valerie Wasinger4, Peter Schwartz5, Peter Graham1,2, John Kearsley1,2, Yong Li1,2 1 Cancer Care Centre, St George Hospital, Gray St, Kogarah, NSW 2217, Australia 2 St George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales (UNSW), Kensington, NSW 2052, Australia 3 SEALS, Anatomical Pathology, St George Hospital, Gray St, Kogarah, NSW 2217, Australia 4 Bioanalytical Mass Spectrometry facility, Mark Wainwright Analytical Centre, UNSW, Kensington, NSW 2052, Australia 5 Breast Surgery, St George Private Hospital, South St, Kogarah, NSW 2217, Australia
P-84 PROTEOMIC VARIATIONS IDENTIFIED BETWEEN INVASIVE AND NONINVASIVE NONFUNCTIONAL PITUITARY ADENOMAS Xianquan Zhan, Xiaowei Wang, Xiaohan Zhan, Zhuchu Chen, Xuejun Li Xiangya Hospital, Central South University
P-85 ITRAQ TECHNOLOGY COMBINED 2DLC-MS/MS DIFFERENTIALLY EXPRESSED PROTEINS IN RENAL CELL CARCINOMA SCREENING Zan Liu, Haiyan Yan, Youcheng Xiu Department Of Urology, The First Affiliated Hospital Of Harbin Medical University
P-86 METABOLIC ADAPTATION IN NON-SMALL CELL LUNG CANCER Alfonso Martín-Bernabé1,2,3,4, Roldán Cortés1, Sylvia G. Lehmann2,3,4, Michel Seve2,3,4, Marta Cascante1, Sandrine Bourgoin-Voillard2,3,4 1 Department of Biochemistry and Molecular Biology, IBUB, Faculty of Biology, Universitat de Barcelona and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. 2 Univ. Grenoble Alpes, IAB, PROMETHEE Proteomic Platform, F-38000 Grenoble, France 3 INSERM, IAB, PROMETHEE Proteomic Platform, F-38000 Grenoble, France 4 CHU de Grenoble, IAB, Institut de Biologie et de Pathologie, PROMETHEE Proteomic Platform, F-38000 Grenoble, France.
112 P-87 AN UNDERSTANDING OF METABOLIC ADAPTATION IN NON-SMALL CELL LUNG CANCER Alfonso Martín-Bernabé1,2,3,4, Roldán Cortés1, Sylvia G. Lehmann2,3,4, Michel Seve2,3,4, Marta Cascante1, Sandrine Bourgoin-Voillard2,3,4 1 Department of Biochemistry and Molecular Biology, IBUB, Faculty of Biology, Universitat de Barcelona and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. 2 Univ. Grenoble Alpes, IAB, PROMETHEE Proteomic Platform, F-38000 Grenoble, France 3 INSERM, IAB, PROMETHEE Proteomic Platform, F-38000 Grenoble, France 4 CHU de Grenoble, IAB, Institut de Biologie et de Pathologie, PROMETHEE Proteomic Platform, F-38000 Grenoble, France.
P-88 GLOBAL PROTEOME CHANGES INDUCED BY C-MYB SILENCING IN K562 HUMAN CHRONIC MYELOID LEUKEMIA CELLS Mariasole Di Carli1, Barbara Tanno1, Cristina Capodicasa1, Maria Elena Villani1, Anna Maria Salzano2, Andrea Scaloni2, Giuseppe Raschella’1, Eugenio Benvenuto1 Marcello Donini1 1 ENEA, UT BIORAD, Centro Ricerche Casaccia, 00123, Rome, Italy 2 Proteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council, 80147 Napoli, Italy
P-89 PROFILING URINARY PROTEOME FOR STRESS INDUCED FEMALE URINARY INCONTINENCE Marianne Koch1, Rosa Laterza1, Wei-Qiang Chen2, Miloš Barut, Sonja Seyfert4, Heinz Kölbl1, Goran Mitulovic2,3 1 Medical University Of Vienna - Clinical Dept. of Gynecology 2 Medical University Of Vienna - Clinical Dept. of Laboratory Medicine 3 Medical University Of Vienna - Proteomics Core Facility
P-90 DISCOVERY AND LONGITUDINAL MEASUREMENT OF CANDIDATE BIOMARKERS OF BIOCHEMICAL RECURRENCE IN PROSTATE CANCER PATIENTS TREATED WITH CHRT Claire Tonry1, Darren Doherty1, Carmel O’Shea2, Brian Morrissey1, Lisa Staunton1, Brian Flately1, Aoife Shannon2, John Armstrong2 Stephen Pennington1 1 Conway Institute Of Biomolecular And Biomedical Research 2 St. Luke’s Hospital, Rathgar, Dublin 6, Co. Dublin, Ireland
P-91 DAILY RHYTHMS IN THE CYANOBACTERIUM SYNECHOCOCCUS ELONGATUS PROTEOME AND PROTEIN COMPLEXES Ana Guerreiro1,2, Renske Penning1,2, Marco Benevento1,2, Robert Lehmann3, Bas van Breukelen1,2, Harm Post1,2, Ilka Axmann3,4, Maarten Altelaar1,2 Albert Heck1,2 1 Utrecht University, Utrecht, The Netherlands 2 Netherlands Proteomics Centre, Utrecht, The Netherlands 3 Humboldt-Universitaet zu Berlin, Berlin, Germany 4 Heinrich-Heine-Universitaet Duesseldorf, Duesseldorf, Germany
113 P-92 PROTEOMIC ANALYSIS OF BENIGN AND MALIGNANT PROSTATE TISSUES BY 2-D DIGE COUPLED WITH MASS SPECTROMETRY TO IDENTIFY NOVEL DIAGNOSTIC MARKERS FOR PROSTATE CANCER Katarina Davalieva1, Sanja Kiprijanovska1, Katerina Kubelka-Sabit2, Vanja Filipovski2, Momir Polenakovik1 1 Research Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia 2 Clinical Hospital “Sistina”, Skopje, Republic of Macedonia
P-93 THE ANTITUMOR NATURAL COMPOUND CURCUMIN PROMOTES PROSTATE CANCER CELL DEATH BY INDUCING ENDOPLASMIC RETICULUM STRESS. Yanilda Ramos1, Maricarmen Colon2, Madeline Rodriguez1, Sheila Lopez1, Luis Cubano1, Jin Zou3, Nawal Boukli1 1 Universidad Central Del Caribe.School of Medicine. Biomedical Proteomics Facility, Department of Microbiology and Immunology. Bayamón, Puerto Rico 2 Universidad San Juan Bautista.Department of Physiology and Pathology, Caguas, Puerto Rico 3 Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, Georgia.
P-94 PROTEOMIC PROFILING OF THYROID NEOPLASMS IDENTIFIES CANDIDATE MARKERS OF TUMOUR MALIGNANCY Juan Martinez-Aguilar1, Roderick Clifton-Bligh2, Mark Molloy1,3 1 Macquarie University 2 Kolling Institute of Medical Research 3 Australian Proteome Analysis Facility
P-95 QUANTITATIVE ANALYSIS OF N-LINKED GLYCOPROTEIN IN THE BRAIN OF APP/PS-1 ALZHEIMER’S DISEASE MODEL Pan Fang, Hong Li, Hongxiu Yu, Huali Shen, Pengyuan Yang Institutes Of Biomedical Sciences Fudan University
P-96 SPATIOTEMPORAL UPAR EXPRESSION IN STAGE B AND C RECTAL CANCER CORRELATES DIFFERENTIALLY WITH PATIENT SURVIVAL Seong Beom Ahn1, Charles Chan2, Julie Fletcher2, Sun Young Kwun2, Candice Clarke2, Owen Dent3, Pierre Chapuis3, Edouard Nice4 Mark Baker5 1 Australian School Of Advanced Medicine, Macquarie University 2 Anatomical Pathology, Concord Hospital, University of Sydney 3 Colorectal Surgery, Concord Hospital, University of Sydney 4 Biochemistry and Molecular Biology, Monash University 5 Australian School Of Advanced Medicine, Macquarie University
P-97 CALIBRATION FREE CONCENTRATION ANALYSIS (CFCA) OF PROTEINS IN COMPLEX SERUM SAMPLES USING SURFACE PLASMON RESONANCE Veenita Shah1,2, Sandipan Ray1, Sanjeeva Srivastava1 1 Indian Institute Of Technology Bombay, Mumbai, India 2 Wipro GE Healthcare, Mumbai, India
114 P-98 STUDY OF GRADE-SPECIFIC PROTEOMIC ALTERATIONS IN GLIOMAS Kishore Gollapalli1, Mayuri Gandhi2, Rapole Srikanth3, Aliasgar Moiyadi4, Sanjeeva Srivastava1 1 Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India 2 CRNTS, Indian Institute of Technology Bombay, Mumbai 400076, India 3 Proteomics Laboratory, National Centre for Cell Science, Ganeshkhind, Pune 411007, India 4 Department of Neurosurgery, Advanced Center for Treatment Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai, India
P-99 QUANTITATIVE SERUM PROTEOMIC ANALYSIS OF MENINGIOMAS FOR THE IDENTIFICATION OF SURROGATE PROTEIN MARKERS Samridhi Sharma1, Sandpan Ray1, Aliasgar Moiyadi2, Epari Sridhar3, Sanjeeva Srivastava1 1 Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India 2 Department of Neurosurgery, Advanced Center for Treatment Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai 410210, India 3 Department of Pathology, Tata Memorial Hospital, Mumbai 400012, India
P-100 IMPROVING SELECTIVITY AND SENSITIVITY IN CLINICAL ASSAYS USING PARALLEL REACTION MONITORING Sebastien Gallien1, Yeoun-Jin Kim1, Guy Berchem2, Bruno Domon1 1 Luxembourg Clinical Proteomics Center, Strassen, Luxembourg 2 CRP-Sante, Strassen, Luxembourg
P-101 MULTIPRONGED QUANTITATIVE TISSUE PROTEOMIC ANALYSES INDICATE MODULATION OF VARIOUS SIGNAL TRANSDUCTION PATHWAYS IN MENINGIOMAS Samridhi Sharma1, Sandipan Ray1, Aliasgar Moiyadi2, Epari Sridhar3, Sanjeeva Srivastava1 1 Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India 2 Department of Neurosurgery, Advanced Center for Treatment Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai 410210, India 3 Department of Pathology, Tata Memorial Hospital, Mumbai 400012, India
P-102 PROTEOMIC ANALYSIS OF G PROTEIN-COUPLED ESTROGEN RECEPTOR 1 (GPER) BY MALDI-TOF/TOF MS Hariprasad Thangavel1, Anna Napli1, Donatella Aiello1, Marcello Maggiolini2, Giovanni Sindona1 1 Department of Chemistry and Chemical Technologies, University Of Calabria 2 Department of Pharmacobiology, University of Calabria
P-103 DISCOVERY OF COLORECTAL CANCER BIOMARKER CANDIDATES BY MEMBRANE PROTEOMIC ANALYSIS AND SUBSEQUENT VERIFICATION USING SELECTED REACTION MONITORING AND TISSUE MICROARRAY ANALYSIS Takeshi Tomonaga, Hideaki Kume National Institute Of Biomedical Innovation
115 P-104 IDENTIFICATION OF AN EXOSOMAL PROTEIN INVOLVED IN INVASION OF BREAST CANCER CELL AND STUDY ON CLEARANCE OF THE EXOSOMES FROM THE CIRCULATION Min-Jeong Yi, Pyong-Gon Moon, Jeong-Eun Lee, Sang-Hyun Kim, Moon-Chang Baek Department Of Molecular Medicine, School Of Medicine, Kyungpook National University
P-105 THE CANCER-DERIVED SECRETORY/RELEASING PROTEOME: A VALUABLE RESOURCE FOR DISCOVERING TUMOR MARKERS Yanning Gao, Ting Xiao, Shujun Cheng Cancer Institute & Hospital, Chinese Academy Of Medical Sciences
P-106 ANALYSIS OF THE EXOSOME UNDER T IRRADIATION. Consuelo Marin-Vicente, Judit Domingo-Prim, Andrea B. Eberle, Neus Visa Stockholm University
P-107 BREAST CANCER TUMOUR TRANSFORMATION FROM PRIMARY TUMOUR TO SECONDARY SITE Emila Kurbasic1, Sofia Waldemarson1, Peter James1, Emma Nimeus-Malmström2 1 Department of Immunotechnology, Lund University 2 Department of Oncology, Lund University
P-108 ALPHA-ACTININ 4 IS ASSOCIATED WITH CANCER CELL MOTILITY AND IS A POTENTIAL DIAGNOSTIC BIOMARKER IN NON-SMALL-CELL LUNG CANCER Ming-Chuan Wang1, Ying-Hua Chang1, Yu-Chang Tyan2, Hua-Chien Chang3, Yih-Gang Goan1, Wu-Wei Lai4, Pin-Nan Cheng1, Pao-Chi Liao1 1 National Cheng Kung University 2 Kaohsiung Medical University 3 Kaohsiung Veterans General Hospital 4 National Cheng Kung University
P-109 IMMOBILIZATION OF ANTIBODIES ON FE3O¬4@POLYDOPAMINE CORE¨CSHELL MICROSPHERES FOR SELECTIVE ENRICHMENT OF LYSINE-ACETYLATED PROTEINS AND PEPTIDES Lu Chen Fudan University
P-110 THE EFFECT OF MUTATIONS IN BETA-AMYLOID ON ZINC ION COORDINATION Igor Popov1,2, Maria Indeykina2, Alexey Kononikhin1,2, Sergey Kozin3, Eugene Nikolaev2,4 1 Moscow Institute of Ohysics and Technology 2 Emanuel Institute of Biochemical Physics RAS 3 Engelhardt Institute of Molecular Biology RAS 4 Talrose Institute for Enerhy Problems of Chemical Physics RAS
116 P-111 IMPROVED METHOD FOR SEQUENCING OF IMMUNOGLOBULIN MOLECULES; COMBINING NEXT GENERATION SEQUENCING AND MS/MS. Svend Birkelund1, Andreas Møller Stehr1, Tue Bennike1, Gunna Christensen2, Mads Sønderkær3, Kåre Lehmann3, Allan Stensballe1 1 Department Of Health Science And Technology, Aalborg University, 9220 Aalborg, Denmark 2 Department for Biomedicine, Aarhus University, 8000 Aarhus C, Denmark 3 Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, 9000 Aalborg, Denmark
P-112 OPTIMIZATION OF A WORKFLOW FOR FAST AND DEEP PROTEOME SEQUENCING Sung Yun Jung, Jun Qin, Wenchuan Leng, Jong Min Choi, Jain Antrix Baylor College Of Medicine
P-113 MS- AND AB-BASED PROTEOMICS TO UNDERSTAND BIOLOGY AND DISEASE OF KIDNEY Tadashi Yamamoto1, Bo Xu1, Ying Zhang1, Sameh Magdeldin1, Masato Habuka1, 2, Hidehiko Fujinaka1, Keiko Yamamoto1, Yutaka Yoshida1 Shin Goto2 Ichiei Narita2 1 Niigata University, BBC And Inst Of Nephrology 2 Niigata University, Department of Nephrology
P-114 IDENTIFICATION OF DISEASE SPECIFIC PATHWAYS THROUGH SILAC PROTEOMICS IN HBX-TRANSGENIC MICE Ping Xu1, Zhongwei Xu1, Linhui Zhai1, Tailong Yi1, Huiying Gao1, Fengxu Fan1, Yanchang Li1, Youliang Wang2 Xiao Yang2 Chunping Cui1 1 Beijing Proteome Research Center 2 Beijing Institute of Bioengineering, Beijing
P-115 A QUANTITATIVE PROTEOMICS TOWARDS THE TISSUE INTERSTITIAL FLUID FROM AOM-DSS MOUSE MODEL OF COLORECTAL CANCER Yang Wang1, Qiang Shan1, Guixue Hou1, Yingying Xie1, Ningzhi Xu2, Xiaomin Lou1, Siqi Liu1 1 Beijing Institute Of Genomics, Chinese Academy Of Sciences, Beijing, China 2 Cancer Institute, Chinese Academy of Medical Sciences, Beijing, China
P-116 THE VITREOUS PROTEOME IN YOUNG AND MATURE NEW ZEALAND WHITE (NZW) RABBITS Deepak Edward1,2, Rachida Bouhenni3, Ying Liu1, Qundeel Rafiq1, Randi Turner1, Craig Dufresne4, Richard Semba1 1 Wilmer Eye institute, Johns Hopkins University School Of Medicine, Baltimore, MD 2 King Khaled Eye Specialist Hospital, Riyadh KSA 3 Summa Health System, Akron, OH 4 Thermo Fisher Training Institute, West Palm Beach, Florida, USA
117 P-117 CHARACTERISTIC PATTERNS OF PROTEIN AND GENE EXPRESSION AS MARKERS FOR DIAGNOSIS AND PROGNOSIS OF MALIGNANT MELANOMA Yoana Arroyo-Berdugo1, Santos Alonso2, Gorka Pérez-Yarza1,3, Aintzane Asumendi1,3, María Dolores Boyano1,3 1 Department of Cell Biology and Histology, University of the Basque Country (UPV/EHU), E-48940 Leioa, SPAIN. 2 Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of Basque Country (UPV/EHU). E-48940 Leioa, SPAIN 3 BioCruces Health Research Institute, Cruces University Hospital.
P-118 COMPREHENSIVE ANALYSIS OF RADIOTHERAPY EFFECTS AFTER IRRADIATION WITH CARBON AND PHOTON USING GENOME-WIDE TRANSCRIPTOMICS AND QUANTITATIVE PROTEOMICS Uwe Warnken1, Tilmann Rackwitz1,2,3,4, Martin Winter1, Philipp Seidel1,2,3,4, Cheng Zhou1,2,3,4, Ramona Mayer1, Amir Abdollahi1,2,3,4, Martina Schnölzer1 1 German Cancer Research Center (DKFZ), Heidelberg, Germany 2 Heidelberg Ion Therapy Center (HIT), Heidelberg, Germany 3 National Center for Tumor Diseases (NCT), Heidelberg, Germany 4 German Cancer Consortium (DKTK), Heidelberg, Germany
P-119 CHEMOKINE RECEPTOR CXCR7 PROMOTES HEPATOCELLULAR CARCINOMA CELL GROWTH AND METASTASIS IN VITRO AND IN VIVO VIA ACTIVATING MAPK PATHWAY Ling Lin, Meimei Han, Hongxiu Yu, Pengyuan Yang Institutes Of Biomedical Sciences Of Shanghai Medical School, Fudan University
P-120 A NOVEL PANEL OF PROTEINS CORRELATING WITH LYMPH NODE METASTASIS OF LOW-GRADE BREAST CANCER AS IDENTIFIED BY COMBINED PROTEOMICS AND TRANSCRIPTOMICS APPROACH Pavel Bouchal1, 2, Monika Dvoøáková1, 2, Theodoros Roumeliotis3, Zbynìk Bortlíèek4, Ivana Ihnatová4, Iva Struhárová1, 2, Eva Budinská1, 4, Spiros D. Garbis3 Boøivoj Vojtìšek1 Rudolf Nenutil1 1 Masaryk Memorial Cancer Institute, Regional Centre For Apllied Molecular Oncology, Brno, Czech Republic 2 Masaryk University, Faculty of Science, Department of Biochemistry, Brno, Czech Republic 3 University of Southampton, UK 4 Masaryk University, Institute of Biostatistics and Analyses, Brno, Czech Republic
P-121 COMPREHENSIVE CHARACTERIZATION OF CELL SECRETOME VIA LC MS/MS ANALYSIS OF CONDITIONED MEDIUM AND SECRETORY PATHWAY ORGANELLES. Agnieszka Latosinska1, Maria Frantzi2, William Mullen3, Antonia Vlahou1, Manousos Makridakis1 1 Biomedical Research Foundation, Academy Of Athens, Athens, Greece 2 Mosaiques Diagnostics GmbH, Hannover, Germany 3 University of Glasgow, Glasgow, United Kingdom
118 P-122 ANTIBODY-BASED PLASMA PROFILING FOR THE IDENTIFICATION OF PROTEIN SIGNATURES IN LYMPHOMA Frauke Henjes1, Kimi Drobin1, Claudia Fredolini1, Mun-Gwan Hong1, Hendrik Hjalgrim2, Bengt Glimelius3, Mathias Uhlén1, Peter Nilsson1 Karin Ekström-Smedby4 Jochen M. Schwenk1 1 Science for Life Laboratory, Royal Institute of Technology - KTH, Solna, Sweden 2 State Serum Institute, Copenhagen, Denmark 3 Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden 4 Department of Medicine, Karolinska Insitute, Solna, Sweden
P-123 CHARTING THE TEMPORAL SIGNALING NETWORK OF EGFR UPON EGF STIMULATION Jun Qin1,2, Yue Chen1, Mei Leng1, Xia Xia2, Antrix Jain1, Amol Onkar1, Sung Jung1, Yi Wang1 1 Baylor College Of Medicine, Houston, TX, USA 2 Beijing Proteome Research Center, Beijing, China
P-124 COMBINING BOTTOM-UP AND MIDDLE-DOWN APPROACHES TO MAP HYPER-MODIFIED HISTONE PEPTIDES USING UHPLC SEPARATION AND QEXACTIVE INSTRUMENT. Alessandro Cuomo, Monica Soldi, Tiziana Bonaldi European Institute of Oncology (IEO)
P-125 NEW POTENTIAL BIOMARKERS FOR PROSTATE CANCER DIAGNOSIS AND PROGNOSIS USING 2D-DIGE Cordelia Geisler1, Nadine T Gaisa1, David Pfister2, Susanne Fuessel3, Christoph H Borchers4,5, Hanna C. Diehl6, Helmut E. Meyer6,7, Axel Heidenreich2 Ruth Knüchel1 Corinna Henkel6 1 Institute of Pathology, RWTH Aachen University, Germany 2 Department of Urology, University Hospital of the RWTH Aachen, Germany 3 Department of Urology, University Hospital Carl Gustav Carus, Dresden, Germany 4 University of Victoria – Genome British Columbia Proteomics Centre, Vancouver Island 5 Department of Biochemistry and Microbiology, University of Victoria, Victoria BC, Canada 6 Medizinisches Proteom-Center, Ruhr-University Bochum, Germany 7 Leibniz-Institut für Analytische Wissenschaften–ISAS–e.V., Dortmund, Germany
P-126 RELATIVE QUANTITATION OF N-LINKED GLYCANS USING CARBONYL-REACTIVE TANDEM MASS TAG™ (TMT™) REAGENTS Sergei Snovida1, Kay Opperman1, Rosa Viner2, Julian Saba2, John Rogers1 1 Thermo Fisher Scientific, Rockford, IL, USA 2 Thermo Fisher Scientific, San Jose, CA, USA
P-127 GC-MS-BASED SEMI-QUANTITATIVE ANALYSIS OF TARGETED METABOLITES IN HUMAN PLASMA Yue Luo, Mohammad Nezami Ranjbar, Chi Zhang, Cristina Di Poto, Rency Varghese, Habtom Ressom Georgetown University
119 P-128 LC-MS/MS-BASED SERUM PROTEOMICS FOR IDENTIFICATION OF BIOMARKERS FOR HEPATOCELLULAR CARCINOMA Tsung-Heng Tsai1, Ehwang Song2, Cristina Di Poto1, Minkun Wang1, Yue Luo1, Rency Varghese1, Yehia Mechref2, Habtom Ressom1 1Georgetown University 2Texas Tech University
P-129 BIOMARKERS BREAST CANCER IDENTIFICATION THROUGH ITRAQ LABELING AND TANDEM MASS SPECTROMETRY Karla G. Calderón-González1, María L. Valero Rustarazo2, María L. Labra-Barrios3, María E. Herrera-Aguirre3, Alejandra Tavera-Tapia3, César I. Bazán-Méndez3, Manuel M. Sánchez Del Pino2, José L Gallegos-Pérez4 Humberto González-Márquez1 José M Hernández3 Gloria León-Ávila5 Sergio Rodríguez-Cuevas, Fernando Guisa-Hohenstein, Juan P. Luna-Arias 1 Universidad Autónoma Metropolitana 2 Universidad de Valencia 3 Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN) ABSciex en Framingham, MA 4 Escuela Nacional de Ciencias Biológicas 5 Instituto De Enfermedades De La Mama, Fundación Del Cáncer De Mama (FUCAM A.C.)
P-130 SERUM PROTEOMIC ANALYSIS OF PATIENTS WITH THE CERVICAL HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION Norma Angélica Galicia1, Vicente Madrid1, Jorge Salmerón2, Alfredo Antúnez2, Guillermo Mendoza3, Ivone Castro1 1 National Institute of Public Health 2 National Institute of Social Security 3 National Autonomous University of Mexico
P-131 PROTEOMIC MAPPING OF GLIOMA ENDOTHELIAL CELL SURFACE PROTEINS Lei Teng, Na Zhang Department Of Neurosurgery, The First Affiliated Hospital Of Harbin Medical University, Harbin, China
P-132 EMILIN-1 AND TALIN-2 ARE MATRIX METALLOPROTEINASE-9 DEPENDENT MECHANISMS OF STIFFNESS IN THE AGING HEART Lisandra E. de Castro Brás1, 2, Kristine Y. DeLeon-Pennell1, 2, Howard Yao2,3, Yuan Tian1, 2, Merry L. Lindsey1, 2,4 1 San Antonio Cardiovascular Proteomics Center 2 Mississippi Center for Heart Research, Department of Physiology and Biophysics, Jackson MS 39216 3 Center of Biostatistics & Bioinformatics, University of Mississippi Medical Center, Jackson MS 39216 4 Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson MS 39216
120 P-133 A QUANTITATIVE TELOMERIC CHROMATIN ISOLATION PROTOCOL (QTIP) TO CHARACTERIZE TELOMERE COMPOSITION CHANGES Larissa Grolimund1, 2, Eric Aeby1, 2, Romain Hamelin1, 3, Diego Chiappe1, 3, Florence Armand1, 3, Marc Moniatte1, 3, Joachim Lingner1, 2 1 EPFL-Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, Lausanne, Switzerland 2 ISREC-Swiss institute for experimental cancer research 3 Proteomics Core Facility
P-134 STEAROYL-COA DESATURASE AS A POTENTIAL NOVEL THERAPEUTIC TARGET IN HEAD AND NECK SQUAMOUS CELL CARCINOMA Vishalakshi Nanjappa1,2, Santosh Renuse1,2, Nazia Syed1,3, Gajanan Sathe1,4, Aneesha Radhakrishnan1,3, T.S. Keshava Prasad1,2,3,4, Harsha Gowda1, David Sidransky5 Akhilesh Pandey5, Aditi Chatterjee1 1 Institute of Bioinformatics, International Technology Park, Bangalore 560066, India 2 Amrita University, Kollam 690525, India 3 Pondicherry University, Puducherry 605014, India 4 Manipal University, Manipal 576104, India 5 Johns Hopkins University School of Medicine, Baltimore MD 21205, USA
P-135 QUANTITATIVE PROTEOMICS OF SERUM IDENTIFIES INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4 (ITIH4) AS A POTENTIAL BIOMARKER OF GASTRIC CANCER Nazia Syed1,2, Yashwanth Subbannayya1,3, Sartaj Ahmad1, Nandini A. Sahasrabuddhe1, Hitendra S. Solanki1, T. S. Keshava Prasad1, Harsha Gowda1, Rekha Vijay Kumar3 Aditi Chatterjee1 Akhilesh Pandey4 1 Institute of Bioinformatics, International Technology Park, Bangalore 560066, India 2 Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry 605014, India 3 Kidwai Memorial Institute of Oncology, Bangalore 560029, India 4 Johns Hopkins University School of Medicine, Baltimore MD 21205, USA.
P-136 MACROPHAGE MIGRATION INHIBITORY FACTOR - A THERAPEUTIC TARGET IN GALLBLADDER CANCER Tejaswini Subbannayya1,2, Pamela Leal Rojas3,4, Santosh Renuse1,2, Mustafa A. Barbhuiya4, T. S. Keshava Prasad1,2, Harsha Gowda1, David Sidransky4, Akhilesh Pandey4 Juan Carlos Roa5 Aditi Chatterjee1 1 Institute Of Bioinformatics, Bangalore, Karnataka, India 2 Amrita University, Kollam, Kerala, India 3 Universidad de La Frontera, Temuco, Chile 4 Johns Hopkins University School of Medicine, Baltimore, MD, USA 5 Pontificia Universidad Catolica de Chile, Santiago, Chile
121 P-137 INVESTIGATION OF DIFFERENTIALLY EXPRESSED PLASMA MEMBRANE GLYCOPROTEINS IN ORAL SQUAMOUS CELL CARCINOMAS Giovana Polachini1, José F. Góis-Filho2, Patrícia Cury1, Fábio Nunes3, Victor Wünsch-Filho4, Hngp Gencapo5, Eloiza Tajara1 1 Faculdade de Medicina de São José Do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil 2 Instituto do Câncer Arnaldo Vieira de Carvalho, São Paulo, SP, Brazil 3 Faculdade de Odontologia da Universidade de São Paulo, São Paulo, SP, Brazil 4 Faculdade de Saúde Pública da Universidade de São Paulo, São Paulo, SP, Brazil 5 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), São Paulo, SP, Brazil
P-138 MEASURING WNT-PATHWAY ACTIVITY IN CANCER MODELS Oliver Poetz1, Christina Esdar2, Cornelia Sommersdorf1, Richard Schneider2, Thomas O. Joos1 1 NMI Natural and Medical Sciences Institute at the University of Tuebingen 2 Merck KGaA
P-139 SOMASCAN™, A TOOL FOR UNCOVERING THE MECHANISM OF ACTION OF ONCOLOGY DRUGS: DIFFERENTIAL PROTEIN SIGNATURES IN ERLOTINIB SENSITIVE AND RESISTANT LUNG CANCER CELL LINES IN VITRO AND IN VIVO Robert Swift, Deb Ayers, Ying Chang, Eduardo Tabacman, Darryl Perry, Sheri Wilcox, Nicholas Saccomano SomaLogic, Inc.
P-140 PROTEOMIC STUDY OF CHROMATOME DYNAMICS REVEALS REGULATORY SWITCHES OF EPIGNOME IN HYPOXIA-INDUCED ONCOGENESIS Siu Kwan Sze, Bamaprasad Dutta Nanyang Technological University
P-141 OVARIAN CANCER: HUNTING BIOMARKERS BY MASS SPECTROMETRY IMAGING AND TISSUE PROTEOMIC Michel Salzet1, Benoit Fatou1, Eric Leblanc2, Isabelle Farré2, Denis Vinatier3, Maxence Wisztorski1, Isabelle Fournier1 1 Université Lille 1 2 Centre Oscar Lambret 3 CHRU Lille
P-142 N-LINKED GLYCOPROTEIN PROFILING FOR BIOMARKER DISCOVERY IN COLORECTAL CANCER Annalisa Nicastri, Antonia Rizzuto, Laura Elia, Caterina Gabriele, Roberto Romano, Rosario Sacco, Giovanni Cuda, Marco Gaspari Magna Graecia University of Catanzaro, Catanzaro, Italy
122 P-143 TEAR PROTEIN BIOMARKERS IDENTIFY LACRIMAL GLAND TUMORS Roger W. Beuerman1,3,4,5, Lay Leng Seah2, Lei Zhou1,4,5 1 Singapore Eye Research Institute 2 Singapore National Eye Centre, Singapore 3 Yong Loo Lin School of Medicine, National University of Singapore, Singapore 4 DUKE-NUS Graduate Medical School, Singapore, Singapore 5 University of Tampere, School of Medicine, Tampere, Finland
P-144 SYSTEM-WIDE CHARACTERIZATION OF DYNAMICS OF CYTOSOLIC MACROMOLECULAR PROTEIN COMPLEXES IN ONCOGENE-INDUCED CELL TRANSFORMATION Joern Dengjel1, Britta Diedrich1, Kristoffer Rigbolt1, Michael Röring2, Armaghan Naik3, Robert F. Murphy3, Tilman Brummer2 1 Dep. Of Dermatology, University of Freiburg 2 Institute of Molecular Medicine and Cell Research, University of Freiburg 3 Lane Center for Computational Biology, Carnegie Mellon University
P-145 PROTEIN CARBONYLATION IN HEPATOCELLULAR CARCINOMA DERIVED FORM VIRUS C AND METABOLIC SYNDROME. TWO DIMENSIONAL FLUORESCENCE DIFFERENCE IN GEL DETECTION. Fernando Ariel Martin1, 4, Mouniya Mebarki2, Romain Ladouce3, Valerie Paradis2, Bertrand Friguet3, Ivan Matic1, Miroslav Radman4 1 Inserm U1001 Paris Decartes Medical School, Paris, France 2 Pathology Service, Beaujon University Hospital, Paris, France 3 Université Pierre et Marie Curie, Paris, France 4 Mediterranean Institute for Life Sciences (MedILS) Split, Croatia
P-146 PROTEOMIC ANALYSIS OF THE HETEROGENEITY OF IN BREAST CANCER Nirma Skrbo1,3,4, Valentina Siino2, Kristin Andersen1,5, Peter James2, Therese Sørlie3,5 1 Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway 2 Lund University Biomedical Centre, Lund, Sweden 3 DInstitute For Cancer Research, Oslo University Hospital Norwegian Radium Hospital Norway 4 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway 5 Cancer Stem Cell Innovation Center, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway.
P-147 VALIDATION OF POTENTIAL BIOMARKERS FOR AJCC STAGE III MELANOMA Cassandra McDonald1, Swetlana Mctier1, Erin Sykes1, Kimberley L. Kaufman2, Penghao Wang4, Ben Crossett3, Eva H. Yang1, Richard Scolyer6,7 Graham Mann5 Richard I. Christopherson 1 1 School of Molecular Bioscience, University Of Sydney 2 Brain and Mind Research Institute, University of Sydney 3 Mass Spectrometry Core Facility, University 4 School of Mathematics and Statistics, University of Sydney 5 University of Sydney at Westmead Millennium Institute, Westmead, NSW 2145, Australia 6 Melanoma Institute Australia, Crows Nest, NSW 1585, Australia 7 Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
123 P-148 INTEGRATIVE ANALYSIS OF ACUTE AND LATE RADIOTHERAPY EFFECTS USING GENOME-WIDE TRANSCRIPTOMICS AND QUANTITATIVE PROTEOMICS Uwe Warnken1, Tilmann Rackwitz1,2, Martin Winter1, Philipp Seidel1,2, Cheng Zhou1,2, Mayer Ramona1, Abdollahi Amir1,2, Martina Schnölzer1 1 German Cancer Research Center (DKFZ) 2 University of Heidelberg Medical School
P-149 MOLECULAR MECHANISMS RELATED TO IRON HOMEOSTASIS AND DISTURBED IN BREAST CANCER Maida de Bortoli, Elena Taverna, Giulia Spinelli, Lucia Radici, Silvia Veneroni, Chiara M. Ciniselli, Paolo Verderio, Rosaria Orlandi, Italia Bongarzone Fondazione IRCCS Istituto Nazionale Tumori
P-150 A DISTRIBUTED SYSTEM FOR THE ANALYSIS OF HIGH THROUGHPUT PROTEOMICS DATA Kenneth Verheggen1,2, Niels Hulstaert1,2, Davy Maddelein1,2, Harald Barsnes3,4, Marc Vaudel3,4, Lennart Martens1,2 1 Department of Medical Protein Research, VIB, B-9000 Ghent, Belgium 2 Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium 3 Proteomics Unit, Department of Biomedicine, University of Bergen, Norway 4 Computational Biology Unit, UniComputing, Bergen, Norway
P-151 IMAGING MASS SPECTROMETRY (IMS) TO DISCRIMINATE BREAST FROM PANCREATIC CANCER METASTASIS IN FFPE TISSUES Detlev Suckau1, Rita Casadonte2, Mark Kriegsmann3, Friederike Zweynert4, Katrin Friedrich5, Gustavo Barreton5, Mike Otto1,3,5, Daniela Aust5 Christian Pilarsky5 Jörg Kriegsmann1,3,5 1 Bruker Daltonik GmbH, Bremen, Germany 2 Proteopath, Trier, Germany 3 University of Heidelberg, Department of Pathology, Heidelberg, Germany 4 Institute of Molecular Pathology Trier, Germany 5 University of Dresden, Department of Pathology, Dresden, Germany 6 Center for Histology, Cytology and Molecular Diagnostics Trier, Germany
P-152 PROFILING OF TRANSMEMBRANE PROTEINS IN HUMAN LYMPHOMA CELLS BASED ON MEMBRANE-EMBEDDED PEPTIDES Ondrej Vit1, Petr Man2, Alan Kadek2, Jan Sklenar3, Lucie Lorkova1, Jana Pospisilova1, Michaela Scigelova4, Gary Woffendin4 Jiri Petrak1 1 Charles University In Prague, First Faculty Of Medicine, Prague, Czech Republic 2 Academy of Sciences of the Czech Republic, Institute of Microbiology, Prague, Czech Republic 3 The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom 4 Thermo Fisher Scientific GmbH, Bremen, Germany
124 P-153 IDENTIFICATION AND SPATIAL LOCALIZATION OF PROTEINS FROM MOUSE BRAIN TUMOR USING A COMBINATION OF MALDI IMAGING AND LC-MALDI Detlev Suckau1, Daniel R. Feldman2, Sergei Dikler3, Jennifer L. Ide2, Mark A. Marchionni4, Charles D. Stiles4, Nathalie Y.R. Agar2,4 1 Bruker Daltonik GmbH, Bremen, Germany 2 Brigham and Women’s Hospital, HMS, Boston, MA 3 Bruker Daltonics, Billerica, MA 4 Dana-Farber Cancer Institute, HMS, Boston, MA
P-154 A SILAC MOUSE-BASED QUANTITATIVE PHOSPHOPROTEOMIC APPROACH TO ANALYZE SRC ONCOGENIC SIGNALING IN XENOGRAFT TUMORS Audrey Sirvent1, Oana Vigy2, Serge Urbach2, Serge Roche1 1 CNRS UMR5237, University of Montpellier 1 and 2, CRBM, 34000 Montpellier, France 2 CNRS UMR5203 INSERM U661, University of Montpellier 1 and 2, IGF, 34000 Montpellier, France
P-155 EXPLORING THE DETECTION LIMITS OF ERG ONCOPROTEIN IN PROSTATE CANCER USING DIFFERENT SAMPLE TYPES SIMULATING CLINICAL SPECIMENS Jintang He1, Tujin Shi1, Athena A. Schepmoes1, Thomas L Fillmore2, Chaochao Wu1, Alagarsamy Srinivasan3, Albert Dobi3, Shiv Srivastava3 Shyh-Han Tan3 Ahmed A Mohamed3 Anshu Rastogi3 Sudhir Srivastava, Wei-Jun Qian, Richard D Smith, Karin D Rodland, Tao Liu, David G Camp, Jacob Kagan 1 Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 2 Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 3 Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Rockville, MD 4 Division of Cancer Prevention, National Cancer Institute, Rockville, MD
P-156 PROTEOGENOMIC ANALYSIS OF GLIOMA STEM CELLS: A POTENTIAL TOOL FOR THE DISCOVERY OF GBM BIOMARKERS Carmen González1, Severine Gharbi1, Vanessa Rodríguez2, Ana Dopazo3, Daniel Tabas1, Alberto Pascual1, Ángel Ayuso2, Juan Pablo Albar1 1Centro Nacional De Biotecnologia (CNB-CSIC), Madrid - España 2Instituto IMDEA Nanociencia, Madrid - España 3Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid - España
P-157 TRANSFORMING GROWTH FACTOR BETA REGULATES NOVEL PROTEINS IN A HUMAN TROPHOBLASTIC CELL MODEL. Susana Novoa-Herrán1, Marta Monge2, Francesc Canals2, Myriam Sánchez-Gómez1 1 Universidad Nacional de Colombia, Bogotá, Colombia. 2 Vall d’Hebron Institute of Oncology, Barcelona, Spain.
125 P-158 FUNCTIONAL PROTEOME ANALYSIS OF TRANSLATIONALLY CONTROLLED TUMOR PROTEIN (TCTP), A NOVEL NEUROFIBROMATOSIS TYPE 1 (NF1)-RELATED PROTEIN Daiki Kobayashi1, Megumi Nagayama1, Mio Hirayama1,2, Sumio Ohtsuki2, Norie Araki1 1 Tumor genetics and Biology, Graduate School of Medical Science, Kumamoto University 2 Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University
P-159 STATHMIN-1 SILENCING INHIBITS METASTATIC PROCESSES IN COLORECTAL CANCER Maxey CM Chung, Wei Wu National University Of Singapore, Singapore
P-160 PROFILING EGFR KINASE INHIBITOR RESISTANCE PATHWAYS IN NON-SMALL LUNG CANCER CELL LINES Ryan Bomgarden1, Gregory Botting2, Ryan Jacobs2, Rosa Viner3, Neelu Puri2, John Rogers1 1 Thermo Fisher Scientific, Rockford, IL USA 2 University of Illinois at Chicago, Rockford, IL 3 Thermo Fisher Scientific, San Jose, CA
P-161 RELATIVE QUANTITATION OF N-LINKED GLYCANS USING CARBONYL-REACTIVE TANDEM MASS TAG REAGENTS Sergei Snovida, Navid Haghdoost, John Rogers Thermo Fisher Scientific, Rockford, IL USA
P-162 PROTEIN DEEP SEQUENCING IN MALIGNANT MELANOMA PATIENT SAMPLES Maria Yakovleva1, Charlotte Welinder1, Göran Jönsson2, Christian Ingvar2, Bo Baldetorp1, Håkan Olsson1, Melinda Rezeli1, Thomas Fehniger1 Elisabet Wieslander1 György Marko-Varga1,3 1 Lund University, Lund, Sweden 2 Skåne University Hospital, Lund, Sweden 3 Tokyo Medical University, Tokyo, Japan
P-163 PROTEOMIC ANALYSIS OF NOVEL NGF-REGULATED TRKA-DEPENDENT TARGETS ASSOCIATED WITH PI3K SIGNALING AND JNK SIGNALING IN SK-N-MC NEUROBLASTOMA CELLS Eun Joo Jung, Ky Hyun Chung, Choong Won Kim Gyeongsang National University
P-164 COMPREHENSIVE IDENTIFICATION OF GENETIC VARIATIONS AT PROTEIN LEVEL WITH LARGE SCALE MS DATASETS Tieliu Shi, Ruifang Cao, Juan Yang, Peng Li East China Normal University
126 P-165 PROTEOME PROFILING OF HUMAN CANCER CELL LINES USING DATA-INDEPENDENT ACQUISITION LABEL-FREE LC-MS Jennifer Hahlbrock, Pedro Navarro, Joerg Kuharev, Ute Distler, Stefan Tenzer Institute For Immunology, University Medical Center Of The Johannes Gutenberg University Mainz
P-166 DECIPHERING PROTEOME CONTENT OF EXOSOMES SECRETED BY LIVER CANCER CELL LINES Terence Chuen Wai Poon1,2,3, Melody Man Ting Lam2,3, Mian He2,4, Wai Hung Lau2,3, Eddy Wing Yin Ng2,3, Arthur Kar Keung Ching2,4, Kwok Wai Lo2,4, Ka Fai To2,4 Nathalie Wong2,4 1 Faculty of Health Sciences, The University of Macau 2 Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong 3 Department of Paediatrics, The Chinese University of Hong Kong 4 Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
P-168 IMMUNOPROFILING OF CANCER – HARVESTING THE IMMUNE SYSTEM AS A SENSOR FOR CANCER Carl Borrebaeck, Christer Wingren Lund University
P-169 DIAGNOSIS OF THE PRESENCE OF NON-SMALL-CELL-LUNG CARCINOMA (NSCLC) USING AUTOANTIBODIES Samuel Chun-lap Lo, Yoki Kwok-chu Butt, Wai-ting Wong Hong Kong Polytechnic University
P-170 IMMUNOCAPTURE LC-MS; A TOOL FOR ISOZYME DIFFERENTIATED MEASUREMENT AND CP-DETERMINATION OF CANCER MARKERS Silje B. Torsetnes1,2, Trine G Halvorsen2, Leon Reubsaet2, Marianne N. Broughton3, Elisabeth Paus3 1 University Of Southern Denmark 2 University Of Oslo 3 Oslo University Hospital
127 P-171 PARALLEL REACTION MONITORING ANALYSIS OF NIPPLE ASPIRATE FLUID FROM BRAZILIAN BREAST CANCER PATIENTS: LOOKING FOR MOLECULAR SIGNATURES Giselle Brunoro1, 2, Dante Pagnoncelli1, Richard Valente1, Jonas Perales1, René Zahedi3, Ana Gisele Neves-ferreira1 1 Oswaldo Cruz Foundation 2 Federal University of Rio De Janeiro 3 Leibniz – Institut für Analytische Wissenschaften
P-172 IDENTIFICATION OF MARKERS OF ENDOMETRIAL CANCER IN EXOSOME-LIKE VESICLES OF UTERINE FLUIDS USING A SUPER SILAC QUANTITATIVE PROTEOMICS APPROACH Irene Campoy1, Marina Rigau1, Tamara Sequeiros1, Elena Martínez1, Lucia Lanau1, Laura Devis1, Antonio Gil-Moreno1, Jaume Reventós1 Eva Colás1 Pierre Thibault2 1 Vall Hebron Research Institute (VHIR) 2 Institute for Research in Immunology and Cancer (IRIC)
P-173 MAPPING THE METALLOPROTEASE DEGRADOME OF BREAST CANCER CELLS THROUGH A GLYCOPROTEIN CAPTURE SILAC PROTEOMIC ANALYSIS Francesc Canals1, Gemma Reverter-Branchat1, Joan-Josep Bech-Serra1, Marta Monge1, Núria Colomé-Calls1, Laura Villarreal1, Luna Martín1, Stephanie Kaspar2 Pierre-Olivier Schmitt3 Carsten Baessmann2 1 Vall D’Hebron Institute Of Oncology (VHIO) 2 Bruker Daltonics, Bremen, Germany 3 Bruker Daltonique,S.A., Wissembourg, France
P-174 TARGETED PROTEOMIC ANALYSIS OF POTENTIAL NEW THERAPEUTIC TARGETS FOR PSORIASIS Isabel Ruppen1, Helia Schonthaler2, Pilar Ximenez-Embun1, Javier Munoz1, Keith Ashman1, Erwin wagner2 1 Proteomics Unit, Spanish National Cancer Research Centre (CNIO), 29029 Madrid, Spain 2 BBVA Foundation-CNIO Cancer Cell Biology Programme, Spanish National Cancer Research Centre (CNIO), 29029 Madrid, Spain
P-175 MOLECULAR EVIDENCE FOR TUMOUR HETEROGENEITY IDENTIFIED BY MALDI TOF IMAGING AND INTACT CELL MASS SPECTROMETRY Sophie Froehlich1, Guenter Allmaier1, Dontscho Kerjaschki2, Martina Marchetti-Deschmann1 1 Vienna University of Technology, Vienna, AUSTRIA 2 Medical University of Vienna, Vienna, AUSTRIA
P-176 THE QUEST FOR ENDOMETRIAL CANCER PROTEIN BIOMARKERS IN UTERINE ASPIRATES Elena Martinez1, Antoine Lesur2, Irene Campoy1, Marina Rigau1, Laura Devis1, Antonio Gil1, Berta Díaz1, Jaume Reventós1 Eva Colás1 Bruno Domon2 1 Vall D’Hebrón Research Institute 2 Centre de Recherche Public de la Santé
128 P-177 QUANTITATIVE ANALYSIS OF YEAST KINETOCHORE COMPLEXES USING SWATH-MS Zuzana Demianova, Michael Schutzbier, Karl Mechtler, Stefan Westermann Institute Of Molecular Pathology, Dr. Bohrgasse 7, 1030 Vienna, Austria
P-178 ECM PROTEOMICS AND CYTOKINE PROFILING IN 3D-CELL CULTURE MODELS Kerstin Pohl1, Sabine Hensler2, Jens Goepfert3, Christopher Pynn1, Nicole Schneiderhan-Marra3, Thomas O. Joos3, Brigitte Angres4, Claudia Hoffmann4 Margareta M. Mueller2 Dieter Stoll1 1 Albstadt-Sigmaringen University of Applied Sciences 2 Furtwangen University of Applied Sciences 3 Natural and Medical Sciences Institute at the University of Tuebingen 4 Cellendes GmbH
P-179 LPS- INDUCED COLORECTAL TUMOR PROTEINS Cira Rosario Caveda1, Meike de Wit2, Remond Finjeman2, Connie Jimenez2, Marina Perez1, Fernando Vidal-Vanaclocha1 1 Universidad CEU San Pablo 2 Cancer Center Amsterdam
P-180 SECRETED PROTEINS IN URINE OF RENAL CELL CARCINOMA PATIENTS: INVESTIGATIONS USING THREE DIFFERENT PROTEOMIC APPROACHES Vanessa Sandim1, 2, Denise Pereira1, Dario Kalume3, Ana Oliveira-Carvalho1, Antonio Ornellas4, 5, Gilda Alves2, Russolina Zingali1, 6 1 Unidade de Espectrometria de Massas e Proteômica, Instituto de Bioquímica Médica, Universidade Federal Do 2Rio De Janeiro, Rio de Janeiro, RJ, Brazil 3 Laboratório de Genética Aplicada, Instituto Nacional do Câncer, Rio de Janeiro, RJ, Brazil 4 Laboratório Interdisciplinar de Pesquisas Médicas, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil 5 Serviço de Urologia, Instituto Nacional do Câncer, Rio de Janeiro, RJ, Brazil 6 Serviço de Urologia, Hospital Mario Kroeff, Rio de Janeiro, RJ, Brazil 7 Laboratório de Hemostase e Venenos, Instituto de Bioquímica Médica, Universidade Federal Do Rio De Janeiro, Rio de Janeiro, RJ, Brazil
P-181 ANALYSIS OF ERLIC TIP-BASED ENRICHMENT OF GLYCOSYLATED SERUM PROTEINS Gerard Such-Sanmartín, Ole Jensen University Of Southern Denmark
P-182 ENRICHMENT OF EGFR/PI3K/AKT/PTEN PROTEINS USING IMMUNOPRECIPITATION AND ANALYSIS WITH MASS SPECTROMETRY-BASED PROTEOMICS Bhavin Patel, Scott Meier, Kay Opperman, Paul Haney, Barb Kaboord, John Rogers Thermo Fisher Scientific, Rockford, IL USA
P-183 INTEGRATED PROTEOMICS FOR CANCER STEM CELLS Norie Araki1, Akiko Nambu1, Uichi Midorikawa1, Souhei Mizuguchi1, Daiki Koabayashi1, Junichi Kuratsu2 1 Dep. Tumor Gene. Biol., Grad. Sch. Med. Sci., Kumamoto University 2 Dep. Neurosurgery, Grad. Sch. Med. Sci., Kumamoto University
129 P-184 A NOVEL AND STRAIGHTFORWARD EXPERIMENTAL NULL STRATEGY ENABLES ACCURATE EVALUATION AND CONTROL OF FALSE-DISCOVERY OF SIGNIFICANTLY-ALTERED-PROTEINS IN LABEL-FREE QUANTITATIVE PROTEOMICS Xiaomeng Shen, Jun Li, Jun Qu Dept. of Pharmaceutical Sciences, SUNY-Buffalo
P-185 PROTEOMIC AND DEGRADOMIC PROFILING OF GLIOBLASTOMA MULTIFORME Oliver Schilling1, Zon W. Lai1, Christopher Nimsky2, Joerg W. Bartsch2 1 Freiburg University 2 Marburg University
P-186 SECRETOME AND DEGRADOME PROFILING SHOWS THAT KALLIKREIN-RELATED PEPTIDASES 4, 5, 6, AND 7 INDUCE TGFB–1 SIGNALING IN OVARIAN CANCER CELLS Jasmin Shahinian1, Daniela Loesssner2, Martin Biniossek3, Jayachandran N. Kizhakkedathu4, Judith Clements2, Viktor Magdolen5, Oliver Schilling2 1 Department of Cardiovascular Surgery, University Heart Center Freiburg - Bad Krozingen, D–79194 Freiburg, Germany. 2 Cancer Program, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia 3 Institute Of Molecular Medicine And Cell Research, University Of Freiburg, D-79104 Freiburg 4 Centre for Blood Research, University of British Columbia, Vancouver BC V6T 1Z3, Canada 5 Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich, D-81675, Germany
P-187 DEMONSTRATION OF ORTHOGONAL COMPLEMENTARY ENRICHMENT METHODS FOR ENHANCED PHOSPHOPEPTIDE PROFILING OF DRUG-TREATED GASTRIC CARCINOMA CELLS Bryon Ricketts, Charles Farnsworth, Hongbo Gu, Xiaoying Jia, Kimberly Lee, Jian Min Ren Cell Signaling Technology
P-188 GLOBAL ANALYSIS OF THE PHOSPHOPROTEOME OF HUMAN BLASTS REVEALS PREDICTIVE PHOSPHORYLATION MARKERS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA WITH AC220 Christoph Schaab1,2, Martin Klammer1, Kathrin Grundner-Culemann1, Heike Pfeifer3, Thomas Oellerich3,4,5, Jürgen Krauter6, Mark Levis7, Alexander E. Perl8 Björn Steffen3 Hubert Serve3,4,5 1 Evotec (München) GmbH, Martinsried, Germany 2 Max Planck Institute of Biochemistry, Martinsried, Germany 3 Department of Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany 4 German Cancer Consortium (DKTK), Heidelberg, Germany 5 German Cancer Research Center (DKFZ), Heidelberg, Germany 6 Department of Medicine, Hematology/Oncology, Medizinische Hochschule Hannover 7 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 8 Hematologic Malignancies Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania
130 P-189 PROTEOMICS PROFILING OF THE THE INTERSTITIAL FLUID OF MURINE BREAST CANCER. Alejandro Gomez-Auli1,2,3, Oliver Schilling1,2, Christoph Peters1, Thomas Reinheckel1,2 1 Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-Universität Freiburg 2 Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-Universität Freiburg 3 Faculty of Biology, Albert-Ludwigs-Universität Freiburg
P-190 PROTEOMIC ANALYSIS IN PATIENTS WITH HEPATOCELLULAR CARCINOMA AFTER LIVER RADIOEMBOLIZATION. PRELIMINARY RESULTS M. Iñarrairaegui1,2, M.I Mora3, N. Fernnadez Ros1, D. D´Avola1,2, B. Sangro1,2, F. Corrales3 1 Liver Unit, Clínica Universidad De Navarra 2 Centro De Investigación Biomédica En Red De Enfermedades Hepáticas Y Digestivas (CIBEREHD) 3 Area De Terapia Génica Y Hepatología, Centro De Investigación Medica Aplicada CIMA, Pamplona, Spain
P-191 PRE-ANALYTICAL VARIABLES FROM BIOBANK SAMPLES IN MALIGNANT MELANOMA Yutaka Sugihara, Charlotte Welinder, Maria Yakovleva1, Bo Baldetorp, György Marko-Varga Lund University, Lund, Sweden
P-192 STOOL PROTEOMICS REVEALS NOVEL CANDIDATE BIOMARKERS FOR COLORECTAL CANCER SCREENING Linda JW Bosch1, Meike De Wit2, Annemieke C Hiemstra1, Sander R Piersma2, Thang V Pham2, Gideon Oudgenoeg2, George L Scheffer1, Sandra Mongera1 M.A. Komor1 Jochim S Terhaar Sive Droste3 Frank A Oort3 Sietze T Van, Turenhout Ilhame, Ben Larbi, Chris JJ Mulder, Beatriz Carvalho, Connie R Jimenez, Remond JA, Fijneman Gerrit, A Meijer 1 Department Pathology, OncoProteomics Laboratory of The Dept. Medical Oncology 2 Department of Gasteroenterology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amster- dam, The Netherlands
P-193 SEARCH AND IDENTIFICATION OF PEPTIDE BIOMARKERS OF COLORECTAL CANCER IN SERA. Igor Azarkin1, Rustam Ziganshin1, Sergey Kovalchuk1,2, Georgy Arapidi1, Nikolay Anikanov1, Olga Ivanova1, Viktoria Shender1, Vadim Govorun1,2 Vadim Ivanov1 1 Ibch Ras 2 Nii Fhm Fmba
P-194 PROTEOME ANALYSIS OF OVARIAN CANCER ASCITES AS A MEDIUM FOR INTERCELLULAR COMMUNICATION Victoria Shender1, Marat Pavlukov1, Georgij Arapidi1, Sergey Kovalchuk1, Nikolay Anikanov1, Rustam Ziganshin1, Vadim Govorun1,2 1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia 2 Scientific Research Institute of Physical-Chemical Medicine, Moscow, Russia
131 P-195 PROTEOMICS-BASED DISCOVERY OF BIOMARKERS FOR PAEDIATRIC ACUTE LYMPHOBLASTIC LEUKAEMIA: CHALLENGES AND OPPORTUNITIES Elena López Villar1, Duojiao Wu2, William C Cho3, Luis Madero1, Xiangdong Wang2,4 1 Hospital Universitario Infantil Niño Jesús, Madrid, Spain 2 Biomedical Research Centre, Fudan University Zhongshan Hospital, Shanghai, China 3 Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong 4 Department of Respiratory Medicine, Zhongshan Hospital Fudan University School of Medicine, Shanghai Respiratory Research Institute, Shanghai, China
132 02 - Regulation of cellular pathways. Role of PTMs
P-196 BORNA DISEASE VIRUS INFECTION IMPACTS HOST PROTEOME AND HISTONE LYSINE ACETYLATION IN HUMAN OLIGODENDROGLIA CELLS Xia Liu1, Zhongyi Cheng2, Peng Xie1 1 Department Of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China 2 Advanced Institute of Translational Medicine, Tongji University, Shanghai, China
P-197 PATHOPHYSIOGICAL TENSILE STRETCH CHANGES THE HUMAN CEREBRAL ENDOTHELIAL CELL PROTEOME Nurul Farhana Jufri1, Eun Hwa Sohn2, Alberto Avolio1, Mark Baker1 1 Macquarie University, Sydney, Australia 2 Kangwon National University, Samcheok, South Korea
P-198 RELEVANCE AND REGULATION OF ARGININE METHYLATION OF THE CARDIAC VOLTAGE-GATED SODIUM CHANNEL Pedro Beltran-Alvarez1, Sara Pagans1, Ramon Brugada1 1 Institute Of Biomedical Research Of Girona Dr. Josep Trueta
P-199 IDENTIFICATION OF NEW MECHANISMS OF CELLULAR RESPONSE TO ANTICANCER THERAPY BY TRACKING CHANGES IN POST-TRANSLATIONAL MODIFICATIONS BY UBIQUITIN AND UBIQUITIN-LIKE PROTEINS. Thomas Bonacci1,2, Stephane Audebert1,2, Luc Camoin1,2, Emilie Baudelet1,2, Ghislain Bidaut1,2, Ini-Isabée Witzel3, Neil D Perkins3, Jean-Paul Borg1,2 Juan-Lucio Iovanna1,2 Philippe Soubeyran1,2 1 Inserm, U1068, CNRS, UMR7258, CRCM, Aix-Marseille Univ, UM 105, Marseille, F-13009, France. 2 Institut Paoli-Calmettes, Marseille Protéomique, Marseille, F-13009, France 3 Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Catherine Cookson Building, Framlington Place, Newcastle Upon Tyne NE2 4HH, UK
P-200 OMICS PROFILING OF PROTEIN AND METABOLITE CHANGES DURING AGEING OF CASPASE-2 DEFICIENT MICE Claire Wilson1, Sonia Shalini1, Joey Puccini1, Andrej Nikolic1, Sharad Kumar1 1 Centre For Cancer Biology, University Of South Australia
P-201 IN GEL DERIVATIZATION OF HISTONE H3 FOR QUANTITATIVE ANALYSIS OF HISTONE MODIFICATIONS Jiajia Chen1, Hong Jin, Pengyuan Yang 1 Fudan University, Shanghai,China
P-202 MRM-BASED QUANTIFICATION OF ACETYLATION METABOLISM ENZYMES Leilei Xu1, Fang Wang1, Yi Wang1, Hongxiu Yu1, Pengyuan Yang1 1 Fudan University,Shanghai,China
133 P-203 THE INFLUENCE OF SIALIC ACID MODIFICATION OF SURFACE PROTEINS ON INTRACELLULAR SIGNALLING Maria Ibanez Vea1, Sara E. Lendal1, Lylia Drici1, Lene Jakobsen1, Giuseppe Palmisano1, Martin R. Larsen1 1Department Of Biochemistry And Molecular Biology, University Of Southern Denmark
P-204 QUANTITATIVE PROTEOMICS FOR STUDYING HUMAN STEM CELLS DIFFERENTIATION Iñigo Barrio-Hernandez1, Kristoffer Rigbolt1, Virginia Sanchez-Quiles1, Moustapha Kassem1, Jörn Dengjel2, Blagoy Blagoev1 1 Syddansk Universitet, Odense, Denmark 2 University of Freiburg, Freiburg, Germany
P-205 IDENTIFICATION OF N-TERMINALLY ACETYLATED KINETOCHORE PROTEINS USING HIGH RESOLUTION MASS SPECTROMETRY Tanja Bange1, Claudio Pathe1, Andrea Musacchio1 1 Max-Planck Institute Of Molecular Physiology
P-206 GLYCOPROTEOMIC STUDY IN RAT SERUM USING ALBUVOID-A SERUM REDUCTION TOOL Haiyan Zheng1, Caifeng Zhao1, Matthew Kuruc2 1 RWJ Medical School and Rutgers, New Jersey, USA 2 Biotech Support Group LLC, New Jersey, USA
P-207 IMMOBILIZATION OF ANTIBODIES ON FE3O4@POLYDOPAMINE CORE¨CSHELL MICROSPHERES FOR SELECTIVE ENRICHMENT OF LYSINE-ACETYLATED PROTEINS AND PEPTIDES Huizhi Fan1, Lu Chen1, Yinghua Yan1, Jun Yao1, chunhui Deng1, pengyuan Yang1 1 Fudan University
P-208 IMMOBILIZATION OF ANTIBODIES ON FE3O¬4@POLYDOPAMINE CORE¨CSHELL MICROSPHERES FOR SELECTIVE ENRICHMENT OF LYSINE-ACETYLATED PROTEINS AND PEPTIDES Huizhi Fan1, Lu Chen1, Yinghua Yan1, Jun Yao1, Chunhui Deng1, pengyuan Yang1 1Fudan University
P-209 UNCOVERING SMALL UBIQUITIN-LIKE MODIFIER SIGNALING NETWORKS Ivo Hendriks1, Joost Schimmel1, Karolin Eifler1, Sabine Cuijpers1, Joel Chang1, Rochelle D’souza3, Jesper Olsen2, Mathias Mann3 Alfred Vertegaal1 1 Leiden University Medical Center, Leiden, the Netherlands 2 Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark 3 Max-Planck Institute for Biochemistry, Martinsried, Germany
134 P-210 DEFINING THE INTERACTOME OF THE TUMOR SUPPRESSOR CYLD AND ITS ROLE IN EGF SIGNALING Virginia Sanchez-Quiles1, Nerea Osinalde1, Vyacheslav Akimov1, Iñigo Barrio-Hernandez1, Chiara Francavilla2, Jesper V Olsen2, Blagoy Blagoev1 1 Center For Experimental Bioinformatics, Bmb, University Of Southern Denmark 2 The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
P-211 BOTTON-UP AND MIDDLE-DOWN APPROACHES FOR COMPREHENSIVE ANALYSIS OF CHROMATIN-BINDING PROTEINS AFTER TREATMENT WITH SODIUM BUTYRATE. Livia Goto-Silva1, Jimmy Rodriguez1, Magno Junqueira1, Gilberto B. Domont1 1 Unidade Proteomica, Departamento de Bioquímica, Instituto de Química, Federal University of Rio de Janeiro
P-212 IDENTIFICATION OF THE MYOFIBRILLAR Z-DISC AS A NODAL POINT IN SKELETAL MYOCYTE SIGNALING BY LARGE-SCALE PHOSPHOPROTEOMICS Lena Reimann1, Heike Wiese1, Anna Lena Fricke1, Yvonne Leber2, Zacharias Orfanos2, Gerald Radziwill1, Peter F.M. van der Ven2, Dieter O. Fürst2 Bettina Warscheid1 1 Institute Of Biology And BIOSS Centre For Biological Signalling Studies, University Of Freiburg 2 Institute For Cellbiology, University Of Bonn
P-213 INTEGRATIVE BIOINFORMATICS FOR PROTEIN PTM NETWORK DISCOVERY: ANALYSIS OF A CANCER DRIVER GENE Cathy Wu1, Karen Ross1, Cecilia Arighi1, Catalina Tudor1, Vijay Shanker1 1 University Of Delaware
P-214 THE ROLES OF HAUSP/USP7 DEUBIQUITINATING ENZYME REGULATING DNA DAMAGE RESPONSE Kwang-Hyun Baek1, Key-Hwan Lim1 1CHA University
P-215 SIRT5 DESUCCINYLATES MITOCHONDRIAL ISOCITRATE DEHYDROGENASE 2 AND REGULATES TUMORGENESIS Wang Fang1, Xu Leilei1, Yu Hongxiu1, Yang Pengyuan1 1 Fudan University,Shanghai, R. P. China
P-216 TARGETED LC-MS EXPERIMENTS FOR THE ACCURATE MAPPING OF ADP-RIBOSYLATION SITES Tomas Koudelka1, Stephan Menzel2, Friedrich Koch-Nolte2, Andreas Tholey1 1 Div. Systematic Proteome Research & Bioanalytics, Christian Albrechts-Universität, Kiel, Germany 2 Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
135 P-217 ELUCIDATING THE ROLES OF LYSINE METHYLTRANSFERASES BASED ON THEIR NON-HISTONE PROTEIN TARGETS USING A NOVEL TECHNIQUE Alexandra Star1,2, Sylvain Lanouette1,2, Zhibin Ning1,2, Janice Mayne1,2, Jean-Francois Couture1,2, Daniel Figeys1,2 1 Ottawa Institute Of Systems Biology 2 University Of Ottawa
P-218 DECIPHERING THE CLEAVAGE SITE SPECIFICITY OF THE SHEDDASES ADAM10 AND ADAM17 Joanna Tucher1, Dennis Linke1, Tomas Koudelka1, Liam Cassidy1, Claudia Tredup2, Rielana Wichert2, Claus Pietrzik3, Christoph Becker-Pauly2 Andreas Tholey1 1 Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany 2 Institute for Biochemistry, Christian-Albrechts-Universität zu Kiel, Kiel, Germany 3 Institute of Pathobiochemistry, Johannes-Gutenberg-Universität, Mainz, Germany
P-219 ACETYLATION,¡AINSTEAD OF UBIQUITINATION, MEDIATES PROTEASOMAL DEGRADATION OF CORE HISTONES DURING SPERMATOGENESIS AND DNA REPAIR Xiao-Bo Qiu1 1 College of Life Sciences, Beijing Normal University
P-220 A SECRETED PROTEIN FROM M. TUBERCULOSIS SUPPRESSES NF-¦ÊB SIGNALING PATHWAY AND PROMOTES INTRACELLULAR SURVIVAL OF MYCOBACTERIA Jing Wang1, Cuihua Liu1 1 Institute Of Microbiology, Chinese Academy Of Sciences
P-221 QUANTITATIVE PHOSPHORYLATION ANALYSIS OF HOST RESPONSES TO DENGUE VIRUS INFECTION Xiaolu Zhao1, Jie Dai3, Hui Zhao2, Xiujuan Zhu1, Xi Zhou1, Ole Jensen3, Chengfeng Qin2, Lin Guo1 1 State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, P.R.China 2 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P.R.China 3 University of Southern Denmark, DK-5230 Odense M, Denmark
P-222 COMPARABLE PATHWAY ANALYSIS OF IGA NEPHRITIS GLOMERULI WITH NORMAL ONE BASED ON SWATH APPROACH Bo Xu1, Ying Zhang1, Yansheng Liu2, Yutaka Yoshida1, Sameh Magdeldin1, Hidehiko Fujinaka1, Eishin Yaoita1, Ruedi Abersold2 Tadashi Yamamoto1 1 Niigata University Medicine School, Japan 2 Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Switzerland.
136 P-223 PROTEOME ANALYSIS OF ENRICHED CARDIAC PROGENITOR AND DOPAMINERGIC NEURONS DERIVED FROM HUMAN EMBRYONIC STEM CELLS REVEALS NOVEL PATHWAYS AND MARKERS Ghasem Hosseini Salekdeh1, Ali Fathi1, Zaniar Ghazizadeh2, Mehdi Mirzaei3, Mehdi Sharifitabar1, Faranak Fatahi1, Ann Goodchild3, Paul Haynes4 Nasser Aghdami2 Hossein Baharvand5 1 Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem2Cell Biology and Technology, ACECR, Tehran, Iran 2 Department of Regenerative Medicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran 3 The Australian School of Advanced Medicine, Faculty of Human Sciences, Macquarie University, Sydney, NSW, 2109, Australia 4 Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, NSW, Australia 5 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
P-224 A PROTEOMIC ANALYSIS OF P27(KIP1)-BINDING PROTEINS REVEALS A ROLE OF THIS PROTEIN ON THE REGULATION OF TRANSCRIPTION THROUGH ITS INTERACTION WITH RNA POLYMERASE II Juan Sebastian Triviño1, Atilla Biçer1, Arnauld Besson2, Edurne Gallastegui1, Josep María Estanyol3, María Jesus Puyol1, Oriol Bachs1, 1 Department of Cell Biology Immunology and Neurosciences, University of Barcelona-IDIBAPS, Barcelona, Spain 2 INSERM UMR1037-Cancer Research Center of Toulouse, Universite De Toulouse, CNRS ERL5294 Toulouse, France 3 Proteomic Unit, Centres Científics I Tecnologics, University of Barcelona, Barcelona, Spain
137 03 - Microvesicle and organelle proteomics
P-225 A POST-TRANSLATIONAL MODIFICATION PROTEOMICS STUDY OF INS CELL MITOCHONDRIA Loïc Dayon1, Antonio Núñez Galindo1, Jaime Santo Domingo2, Pilar Giner1, Umberto De Marchi2, Andreas Wiederkehr2, Martin Kussmann1, 3, 4 1 Molecular Biomarkers Core, Nestlé Institute of Health Sciences, Lausanne, Switzerland 2 Mitochondrial Function Core, Nestlé Institute of Health Sciences, Lausanne, Switzerland 3 Faculty of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland 4 Faculty of Science, Aarhus University, Aarhus, Denmark
P-226 NUCLEAR PROTEOMICS REVEALS THE LINK BETWEEN MINICHROMOSOME MAINTENANCE COMPLEX AND GLUCOSE-INDUCED PROLIFERATION OF RAT PANCREATIC INS-1E B-CELLS Domitille Schvartz1, Yohann Couté2,3, Jean-Charles Sanchez1 1 University Of Geneva, Geneva, Switzerland 2 INSERM, Grenoble, France 3 Université Grenoble-Alpes, Grenoble, France
P-227 LABEL-FREE QUANTITATIVE MASS SPECTROMETRIC ANALYSIS OF COMPLEX PROTEOME ALTERATIONS IN THE AGING MUNICH WISTAR FRÖMTER RAT BRUSH BORDER MEMBRANE Mark Wagner1, Xianyin Lai1, Bruce Molitoris1, Frank Witzmann1 1 Indiana University School Of Medicine, Indianapolis IN USA
P-228 IN DEPTH PROFILING OF PROTEINS IN EXOSOMES RELEASED FROM SCIRRHOUS GASTRIC CANCER CELL Satoshi Muraoka1, Ayako Sato1, Hideaki Kume1, kazunari Hashiguchi1, Jun Adachi1, Yuuki Hashimoto1, Kazuna Fukamizu1, Takeshi Tomonaga1 1 National Institute Of Biomedical Innovation
P-229 ISOLATION AND PROTEOMIC ANALYSIS OF EXTRACELLULAR MEMBRANE VESICLES OF STREPTOCOCCUS PNEUMONIAE Chi Won Choi1, Edmond Changkyun Park1, Sung Ho Yun1, Youn Hee Hong1, Yeol Gyun Lee1, Sang-Yeop Lee1, Gun-Hwa Kim1, Seung Il Kim1 1 Korea Basic Science Institute
P-230 PROTEOMIC ANALYSIS OF IMMUNOAFFINITY-ISOLATED URINARY EXOSOMES Siri Hildonen1, Leon Reubsaet1, Trine Grønhaug Halvorsen1 1 Department of Pharmaceutical Chemistry, School Of Pharmacy, University Of Oslo
138 P-231 MILK FAT GLOBULE PROTEOMICS FOR UNDERSTANDING THE CONTRIBUTION OF EPITHELIAL CELLS IN INNATE IMMUNITY OF THE MAMMARY GLAND Salvatore Pisanu1, Daniela Pagnozzi1, Tiziana Cubeddu2, Stefania Ghisaura1, Gavino Marogna3, Stefano Rocca2, Sergio Uzzau1, Maria Filippa Addis1 1 Porto Conte Ricerche, Alghero, Italy 2 Università di Sassari, Sassari, Italy 3 Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy
P-232 PROTEOMIC ANALYSES OF EXTRACELLULAR VESICLES FROM THE PARASITIC TREMATODES FASCIOLA HEPATICA AND DICROCOELIUM DENDRITICUM Dolores Bernal1, Maria Trelis2, Sergio Montaner2, Alicia Galiano2, Antonio Marcilla2 1Universitat de València, Dept. Bioquimica i Biologia Molecular 2 Universitat de València, Dept. Biologia Cel.lular i Parasitologia
P-233 QUANTITATIVE PROTEOMIC ANALYSIS OF MICROPARTICLES IN HYPERTENSIVE PATIENTS WITH ELEVATED CARDIP-RENAL RISK Fernando De La Cuesta1, Montserrat Baldan-Martin1, Rafael MorenP-Luna1, Gloria Alvarez-Llamas2, Laura González-Calero2, Juan A. Lopez3, Jesus Vazquez3, Fernando Vivanco2 Luis M. Ruilope4 Maria G. Barderas1 1 Department of Vascular Physiopathology, Hospital Nacional De Paraplejicos SESCAM, Toledo 2 Department of Immunology. IIS-Fundacion Jimenez Diaz, Madrid 3 Unidad de Proteomica , CNIC, Madrid 4 Department of Cardiovascular risk and Hypertension. IIS-Hospital 12 de Octubre, Madrid
P-234 PROTEOMIC STUDY OF BLOOD-DERIVED MICROPARTICLES IN MULTIPLE SCLEROSIS Serena Camerini1, Maria luisa Casella1, Denise Soldati1, Marco Crescenzi1, Paola Margutti1 1 Istituto Superiore Di Sanità
P-235 A TRANSFER LEARNING FRAMEWORK FOR ORGANELLE PROTEOMICS DATA Lisa Breckels1, Sean Holden1, Kathryn Lilley1, Laurent Gatto1 1 University Of Cambridge, UK
P-236 FRACTIONATION PROFILING: A FAST AND VERSATILE APPROACH FOR MAPPING VESICLE PROTEOMES AND PROTEIN-PROTEIN INTERACTIONS. Georg Borner1, Marco Hein1, Jennifer Hirst2, James Edgar2, Margaret Robinson2, Mathias Mann1 1 Max Planck Institute Of Biochemistry 2 Cambridge Institute for Medical Research, UK
P-237 SUBCELLULAR PROTEOMICS OF HUMAN EMBRYONIC STEM CELLS Faezeh Shekari1, Hossein Nezari1, Chia-Li Han2, Hossein Baharvand1, Yu-Ju Chen2, S. Ghasem Hosseini Salekdeh1,3 1 Royan Institute, Tehran, Iran 2 Academia Sinica, Taipei, Taiwan 3 Agricultural Biotechnology Research Institute of Iran, Karaj, Iran
139 P-238 CENTRAL COMPONENTS OF THE PEROXISOMAL MATRIX PROTEIN IMPORT MACHINERY ARE SUBSTRATES OF CYTOSOLIC KINASES Andreas Schummer1, Sven Fischer1, Ida Suppanz1, Thomas Gronemeyer2, Silke Oeljeklaus1, Bettina Warscheid1 1 Institute of Biology II and BIOSS Centre For Biological Signalling Studies, University of Freiburg, Freiburg, Germany 2 Institute of Molecular Genetics and Cell Biology, Ulm University, Ulm, Germany
P-239 URINARY EXOSOMES REFLECT PROTEOMIC CHANGES AT TISSUE LEVEL. A NOVEL TOOL FOR NON-INVASIVE DETECTION OF KIDNEY INJURY IN DIABETIC NEPHROPATHY. Irene Zubiri1, Maria Posada-Ayala1, Aroa S. Maroto1, Marta Martin-Lorenzo1, Pablo Cannata-Ortiz1, Fernando de la Cuesta2, Laura Gonzalez-Calero1, Alberto Ortiz1 Fernando Vivanco1,3 Gloria Alvarez-Llamas1 1 IIS-Fundacion Jimenez Diaz, Madrid, Spain 2 Hospital Nacional de Paraplejicos SESCAM, Toledo, Spain 3 Universidad Complutense de Madrid, Spain
P-240 PROTEOMIC PROFILING OF EXOSOMES FROM CEREBROSPINAL FLUID Patrick Oeckl1, Fabian Metzger1, Emily Feneberg1, Albert Ludolph1, Markus Otto1 1 Ulm University Hospital
P-241 PROTEOMIC IDENTIFICATION OF MICROVESICLE BIOMARKERS IN ST-ELEVATION MYOCARDIAL INFARCTION Paula Vélez1,2, Andrés F. Parguiña1,2, Raymundo Ocaranza-Sánchez3, Lilian Grigorian-Shamagian3, Isaac Rosa1,2, Sergio Alonso-Orgaz4, Fernando de la Cuesta4, María G. Barderas4 José Ramón González-Juanatey3 Ángel García1,2 1 Platelet Proteomics Group. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela 2 Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain 3 Cardiology Department and Coronary Unit, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain 4 Department of Vascular Physiopathology, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain
P-242 PHENOTYPIC CHARACTERIZATION OF EXOSOMES PRESENT IN BLOOD BY EXTRACELLULAR VESICLE (EV) ARRAY – IS THE EXOSOME PROFILE A REFLECTION OF THE DISTRIBUTION OF THE LEUKOCYTE SUBPOPULATIONS IN BLOOD? Lotte Pugholm1, Anne Elbaek1, Malene Joergensen1, Rikke Baek1, Evo Soendergaard1, Kim Varming1 1Department Of Clinical Immunology, Aalborg University Hospital
P-243 COMPARISON OF SUPER-SILAC AND SWATH-MS TECHNIQUES: APPLICATION FOR QUANTIFYING THE MOUSE SYNAPTIC MITOCHONDRIAL PROTEOME. Kelly Stauch1, Pawel Ciborowski1, Howard Fox1 1 University Of Nebraska Medical Center
140 P-244 THE AGING MOUSE BRAIN SYNAPTIC MITOCHONDRIAL PROTEOME: PRESERVATION OF FUNCTION THROUGH HORMESIS. Kelly Stauch1, Phillip Purnell1, Howard Fox1 1 University Of Nebraska Medical Center
P-245.00 PROTEOMIC STUDY OF EXTRACELLULAR VESICLES OF HUMAN MACROPHAGES IN RESPONSE TO CANDIDA ALBICANS INFECTION Jose Antonio Reales-Calderon1, Gloria Molero1, Lucia Monteoliva1, Concha Gil1 1 Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
P-246 THE SUBCELLULAR PROTEIN ATLAS Emma Lundberg1, Hammou Ait Blal1, Frida Danielsson1, Martin Hjelmare1, Diana Mahdessian1, Rutger Schutten1, Marie Skogs1, Charlotte Stadler1 Mikaela Wiking1 Mathias Uhlén1 1 Science For Life Laboratory (KTH)
P-247 PROTEOMIC CHARACTERIZATION OF DETERGENT-RESISTANT PLASMA MEMBRANE MICRODOMAINS: SIMILARITIES AND DISSIMILARITIES BETWEEN PLANT AND OOMYCETE Vaibhav Srivastava1, Hugo Melida, Erik Malm, Vincent Bulone 1 Royal Institute Of Technology, KTH
P-248 PROTEOMIC ANALYSIS OF CEREBROSPINAL FLUID EXTRACELLULAR VESICLES: A COMPREHENSIVE DATASET D. Chiasserini1,2, J.R Van Weering3, S.R. Piersma1, T.V Pham1, A Malekzadeh4, C.E. Teunissen4, H De Wit3, Cr Jiménez1 1 OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. 2 Department of Medicine, Section of Neurology, University of Perugia, Perugia, Italy 3 Department of Functional Genomics and Clinical Genetics, Center For Neurogenomics and Cognitive 4 Research, Neuroscience Campus Amsterdam, VU University Amsterdam, VU University Medical Center, The Netherlands. 5 Department of Clinical Chemistry, Neurochemistry Laboratory and Biobank, VU University Medical Center, Amsterdam, The Netherlands
141 04 - Proteogenomics
P-249 QUANTITATIVE AND QUALITATIVE PROTEOME CHARACTERISTICS EXTRACTED FROM IN-DEPTH INTEGRATED GENOMICS AND PROTEOMICS ANALYSIS Henk van den Toorn1,2,6, Teck Low1,2,6, Sebastiaan van Heesch3,6, Piero Giansanti1,2, Alba Cristobal1,2, Bas van Breukelen1,2, Shabaz Mohammed1,2,4, Edwin Cuppen3 Victor Guryev3,5 Albert Heck1,2 1 Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands 2 Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, the Netherlands 3 Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands 4 Present address: Departments of Chemistry and Biochemistry, University of Oxford, Physical & Theoretical Chemistry Laboratory,South Parks Road, OX1 3QZ Oxford, UK 5 Present address: European Research Institute for the Biology of Ageing, University of Groningen, 6 University Medical Center Groningen, Antonius Deusinglaan, 1, Building 3226, 9713 AV Groningen, the Netherlands
P-250 NEXTSEARCH: DISCOVERY OF NOVEL TRANSCRIPTS USING NUCLEOTIDE-BASED SPLICE GRAPHS Hyunwoo Kim1, Heejin Park2, Eunok Paek2 1 Department of Electronics and Computer Engineering, Hanynag University 2 Division of Computer Science and Engineering, Hanyang University
P-251 DISCOVERY OF NOVEL ALTERNATIVE SPLICE VARIANTS IN HUMAN HEPATOCELLULAR CARCINOMA CELLS Chen Chen, Weimin Zheng, Xiaohui Liu, Lei Zhang, Pengyuan Yang Fudan University
P-252 CAPER 3.0: A SCALABLE CLOUD-BASED PIPELINE FOR THE DATA-INTENSIVE ANALYSIS OF PROTEOMIC DATASETS Shuai Yang, Dan Wang, Feifei Guo, Dong Li, Fuchu He Beijing Proteome Research Center
P-253 REVISITING THE IDENTIFICATION OF CANONICAL SPLICE ISOFORMS THROUGH INTEGRATION OF FUNCTIONAL GENOMICS AND PROTEOMICS EVIDENCE Hongdong Li1, Rajasree Menon1, Gilbert Omenn1,2,3,5, Yuanfang Guan1,2,4 1 Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA 2 Internal Medicine, University of Michigan, Ann Arbor, MI, USA 3 Human Genetics, University of Michigan, Ann Arbor, MI, USA 4 Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA 5 School of Public Health, University of Michigan, Ann Arbor, MI, USA
142 P-255 PROTEOMIC ANALYSIS IN PTERYGIUM Boram Lee1, Jonghoon Lee1, Taiyoun Rhim1, Sun Woong Kim2 1 Hanyang University 2 Hando Hospital
P-256 THE FUNCTIONAL ROLE OF INFLAMMATORY BIOMARKER IN RECURRENT PREGNANCY LOSS Jin-Ock Kim1, Lan Li1, Jung-Hyun Park1, Bum-Chae Choi2, Sangjin Song2, Kwang-Hyun Baek3 1 CHA University 2 CL Women¡¯s Hospital 3 CHA University
P-257 SPLICE ISOFORMS IN TRIPLE-NEGATIVE BREAST CANCERS Rajasree Menon, Gilbert S Omenn Center For Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA
143 05 - Proteomics of obesity & related metabolic liver disorders
P-258 A COMPREHENSIVE AND SCALABLE AUTOMATED WORKFLOW FOR HUMAN PLASMA PROTEOMICS AND ITS APPLICATION TO THE DIOGENES CLINICAL STUDY Loïc Dayon1, Antonio Núñez Galindo1, John Corthésy1, Ornella Cominetti1, Armand Valsesia2, Jörg Hager2, Martin Kussmann1, 3, 4 1 Molecular Biomarkers Core, Nestlé Institute of Health Sciences, Lausanne, Switzerland 2 Obesity & Weight Management Core, Nestlé Institute of Health Sciences, Lausanne, Switzerland 3 Faculty of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland 4 Faculty of Science, Aarhus University, Aarhus, Denmark
P-259 MATURE ADIPOCYTE PROTEOME REVEALS ALTERED METABOLIC AND REGULATORY ACTIVITY BETWEEN LEAN, OVERWEIGHT AND OBESE: USING PROTEOMIC APPROACH AND NETWORK ANALYSIS. Hicham Benabdelkamel1, Afshan Masood1, Ghaith M Almidani1, Abdulmajeed A Alsadhan1, Abdulelah Bassas2, Mark W Duncan1,3, Assim A Alfadda1, 4, 1 Obesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi Arabia 2 Department of Surgery, Security Forces Hospital, P.O.Box 3643, Riyadh 11481, Saudi Arabia 3 Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, School of Medicine, 4 MS8106, E. 19th Avenue, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, USA 5 Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (38), Riyadh 11461, Saudi Arabia
P-260 HEPATIC SILAC PROTEOMIC ANALYSIS OF THE PANDER TRANSGENIC MOUSE REVEALS NOVEL LIPOGENIC PATHWAYS Mark Athanason1, Harris Bell-Temin, Stanley Stevens, Brant Burkhardt University of South Florida, Department of Cell Biology
P-261 INVESTIGATION OF ADIPOCYTE PROTEOME DURING THE DIFFERENTIATION OF BROWN PREADIPOCYTES Kwang-Hee Bae1, Abu Hena Mostafa Kamal1, Sung Goo Park2, Byoung Chul Park2, Jang Seong Kim1, Sang Chul Lee1 1 Research Center For Integrated Cellulomics, Korea Research Institute Of Bioscience And Biotechnology 2 Medical Proteomics Research Center, Korea Research Institute Of Bioscience And Biotechnology
P-262 A STUDY OF TWO SEQUENTIAL MEDIA FOR IVF Jia Wan1, Sonja Seyfert1, Tanja Panic1, Goran Mitulovic1 1 Medical University Vienna
144 P-263 INTAKE OF ISOFLAVONES ATTENUATES THE DEVELOPMENT OF METABOLIC SYNDROME ASSOCIATED WITH CONSUMPTION OF A WESTERN-STYLE DIET IN C57BL/6J MICE Tomoko Oya-Ito1, Kazuhiro Katada1, Mayuko Morita1, Katsura Mizushima1, Yasuki Higashimura1, Osamu Handa1, Tomohisa Takagi1, Yoshito Itoh1 Yuji Naito1 Toshikazu Yoshikawa1 1 Kyoto Prefectural University Of Medicine
P-264 DIAGNOSING IMPAIRED GLUCOSE TOLERANCE USING DIRECT MASS SPECTROMETRY OF BLOOD PLASMA METABOLITES Petr Lokhov1, Oxana Trifonova1 1 Institute Of Biomedical Chemistry RAMS
P-265 A PROTEOMIC APPROACH TO IDENTIFY BIOMARKERS OF FOOD CRAVING AND RESPONSE TO BARIATRIC SURGERY IN MORBID OBESITY Carmen Perez-Garcia1, Marta Vicente-Rodriguez1, Teresa Rodriguez-Cano2, Jesus Martin2, Rhian-Marie Ford1, Jose Ramon Muñoz-Rodriguez2, Carmen Gonzalez-Martin1,2, Esperanza Segura2 Matilde Sanchez2 Luis Fernando Alguacil1,2 1 University CEU San Pablo 2 Hospital General de Ciudad Real
P-266 QUANTITATIVE STUDY OF HUMAN ADIPOSE TISSUE SECRETION BY CILAIR SHOWS LOCATION-SPECIFIC DIFFERENCES BETWEEN VISCERAL AND SUBCUTANEOUS FAT DEPOTS Arturo Roca-Rivada1, Susana B Bravo2, Jana Alonso3, Diego Pérez-Sotelo1, María Larrosa1, Felipe F Casanueva4, María Pardo1 1 Grupo Obesidómica. Instituto De Investigaciones Sanitarias De Santiago De Compostela (IDIS) 2 Servicio de Proteómica. Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS) 3 MRC Protein Phosphorylation & Ubiquitylation Unit. University of Dundee, Dundee (UK) 4 Laboratorio de Endocrinología Molecular y Celular. Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS)
P-267 EVALUATION OF INTRACELLULAR TRACE ELEMENTS, MRNA EXPRESSION AND PROTEIN ABUNDANCES IN HUMAN LIVER Guadalupe Espadas1, Johannes Engelken2,3, Francesco M. Mancuso1, Elena Bosch2, Eduard Sabidó1 1 Proteomics Unit CRG/UPF, Barcelona, Spain 2 Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Barcelona, Spain 3 Evolutionary Genetics, Max Planck Institut, Leipzig, Germany
145 P-268 COMPREHENSIVE PROTEOMIC ANALYSIS OF 3D HUMAN LIVER SPHEROIDS FOR DRUG TOXICITY INVESTIGATION Nathalie Selevsek1, Jonas Grossmann1, Paolo Nanni1, Claudia Fortes1, Patrina Gunness2, Jens Kelm2, Ralph Schlapbach1, 1 Functional Genomics Center Zurich (FGCZ), Zurich, Switzerland 2 InSphero AG, Schlieren, Switzerland
P-269 SERUM PROTEOMIC PROFILE OF MEXICAN PATIENTS WITH “DIABESITY” Erik Elvin Gómez-Cardona1, Eric Edmundo Hernández-Domínguez1, José Ángel Huerta-Ocampo1, Alberto Barrera-Pacheco1, Agustín Díaz-Gois2,3, Ana Paulina Barba de la Rosa1 1 IPICyT, Instituto Potosino de Investigación Científica y Tecnológica A.C. San Luis Potosi, Mexico 2 Jurisdicción Sanitaria No.1, Centros de Salud, S.L.P., Mexico 3 Clínica Pedro Barcena Hiriart-ISSSTE, S.L.P., Mexico
P-270 DISSECTION OF METABOLIC PATHWAYS IN THE DBDB MOUSE MODEL BY INTEGRATIVE PROTEOME AND ACETYLOME ANALYSIS Soraya Hoelper1, Hendrik Nolte1, Thomas Braun1, Marcus Krüger1 1 Max-Planck-Institute For Heart And Lung Research In Bad Nauheim
P-271 PROTEOMIC ANALYSIS OF SERUM INDICATE FIBRINOGEN AS POTENTIAL BIOMARKER IN EARLY DIAGNOSIS OF HEPATOLENTICULAR DEGENERATION IN PEDIATRIC AND ADULT SUBJECTS Grzegorz Bazylak1, Tai-Long Pan2, Pei-Wen Wang2, Wen-Neng Chang3, Yu-Chiang Hung2,3 1 Nicolaus Copernicus University, Faculty of Pharmacy, Bydgoszcz, POLAND 2 Chang-Gung University, School of Traditional Chinese Medicine,Taoyuan,Taiwan, ROC 3 Chang Gung Memorial Hospital, Kaohsiung,Taiwan, ROC
P-272 SUBTRACTIVE PROTEOMIC ANALYSIS ALLOWS DEFINITION OF LIPID DROPLET ASSOCIATED PROTEIN (LDP) AND UNRAVELS DIFFERENTIAL LIVER LDP PROFILING IN FATTY LIVER DISEASE Mingwei Liu1,2, Chen Ding1,2, Wanlin Liu1,2, Gaigai Guo1,2, Tianyi Fu1,2, Sung Yun Jung3, Bei Zhen1,2, Yi Wang3 Lawrence C.B. Chan3 Jun Qin1,2,3 1 Beijing Proteome Research Center 2 National Engineering Research Center for Protein Drugs 3 Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Cellular Biology, Baylor College of Medicine
146 P-273 HIGH FAT DIET INDUCED ISOFORM CHANGES OF THE PARKINSON’S DISEASE PROTEIN DJ-1 Gereon Poschmann1, Katrin Seyfarth2, Daniela Besong Agbo3, Hans-Wolfgang Klafki3, Jens Wiltfang4, Helmut E. Meyer5, Martin Klingenspor2, Kai Stühler1 1 Heinrich-Heine-Universität Düsseldorf 2 Technische Universität München 3 University of Duisburg-Essen 4 Georg-August-University Göttingen 5 Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V.
P-274 GAINING INSIGHT INTO OBESITY AND RELATED PATHOLOGIES BY HIGH-THROUGHPUT PROTEOMIC ANALYSIS OF HUMAN ADIPOSE TISSUE Belén Peral1, María Gómez-Serrano1, Eva García-Santos1, Juan A . López2, Emilio Camafeita2, Jesús Vázquez2 1 Instituto De Investigaciones Biomédicas, Alberto Sols (CSIC-UAM), Madrid, Spain 2 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
P-275 A LABEL-FREE PROTEOME WIDE BINDING STUDY TO REVEAL FUNCTIONALLY RELEVANT SNP VARIANT DNA BINDERS Stefanie Hauck1,4, Heekyoung Lee2,3,4,5, Melina Claussnitzer2,3,4,5,6, Christine von Toerne1,4, Hans Hauner2,3,4,5, Helmut Laumen2,3,4,5 1 Research Unit Protein Science, Helmholtz Zentrum Muenchen 2 Else Kroener-Fresenius-Centre for Nutritional Medicine, Chair of Nutritional Medicine, Technische Universität München 3 ZIEL - Research Centre for Nutrition and Food Sciences, Technische Universität München 4 German Center for Diabetes Research (DZD) 5 Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München and Technische Universität München 6 Hebrew SeniorLife Institute for Aging Research, Harvard Medical School
P-276 ADVANCED GLYCATION END-PRODUCTS AS PROSPECTIVE DIABETIC PEPTIDE-BIOMARKERS Uta Greifenhagen1, 2, Matthias Blüher3, Ralf Hoffmann1, 2, Andrej Frolov1, 2 1 Institute Of Bioanalytical Chemistry, Faculty For Chemistry And Mineralogy, Universität Leipzig 2 Center for Biotechnology and Biomedicine, Universität Leipzig 3 Universitätsklinikum Leipzig, Department of Internal Medicine, Clinics of Endocrinology and Nephrology
P-277 MS BASED APPROACHES FOR STUDYING THE PHARMACOKINETICS OF AN INNOVATIVE LIVER TARGETED COPPER CHELATOR IN ATP7B -/ MICE USED AS A MODEL FOR STUD- IES OF WILSON’S DISEASE Brun Virginie1, Arrivé Clémence 1, Delangle Pascale 2, Mintz Elisabeth3, Gateau Christelle2, Bruley Christophe 1, Rivaux Céline3, Jaquinod Michel1 1 CEA/DSV/iRTSV/BGE/EDyP 2 CEA/DSM/INAC 3 CEA/DSV/iRTSV/LCBM
147 P-278 ONE-WEEK PALMITATE TREATMENT MODIFIES HUMAN ISLET INSULIN SORTING AND PROCESSING Domitille Schvartz1, Ernest Sargsyan2, Kirsten Roomp3, Azazul Chowdhury2, Reinhard Schneider3, Peter Bergsten2, Jean-Charles Sanchez1 1 University Of Geneva, Geneva, Switzerland 2 Uppsala University, Uppsala, Sweden 3 University of Luxembourg, Luxembourg
P-279 MYOCARDIAL PROTEOME DURING METABOLIC SYNDROME AND TYPE 2 DIABETES IN ZUCKER DIABETIC FATTY RATS Anders V. Edhager1, Jonas A. Povlsen2, Bo Løfgren2, Hans Erik Bøtker2, Johan Palmfeldt1 1 Research Unit for Molecular Medicine, Department of Clinical Medicine, Aarhus University and Aarhus 2 University Hospital, Aarhus, Denmark 3 Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
P-280 NUCLEAR PROTEOMIC STUDY OF C2C12 MYOTUBES WITH ALTERNATED INSULIN SENSITIVITY INDUCED BY PALMITIC ACID Leung Chung Ning1, Ngai Sai Ming1 1 The Chinese University of Hong Kong, Hong Kong
P-281 IMPLICATIONS OF METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENCY IN LIVER INJURY Emilie Bigaud1, Fernando J. Corrales1 1 Division of Hepatology and Gene Therapy, Proteomics Laboratory. Centre For Applied Medical 2 Research (CIMA), University of Navarra. 31008, Pamplona, Spain
P-282 PROFILING OF CELL SURFACE PROTEOME AND METABOLOME FROM AN IN-VITRO MODEL SYSTEM, USING LC-MS TECHNOLOGIES Lynette Lincoln1, Leo E Bonilla2, Arunkumar Padmanaban1, Syed Salman Lateef1, Ravi K Krovidi1 1 Agilent Technologies India Pvt. Ltd, Bangalore, 560 048, India 2 Agilent Technologies, Santa Clara, USA
148 06 - Phosphoproteomics
P-283 COMPARISON OF AN ORBITRAP FUSION SYSTEM PERFORMANCE WITH AN ORBITRAP VELOS PRO USING SOLID PHASE AMINP-LABELLING WITH TMTS ON COMPLEX DIGESTS FOR SUBSEQUENT PHOPHOPEPTIDE ENRICHMENT Gitte Boehm, Petra Préfot, Stephan Jung, Vikram Mitra, David Britton, Karsten Kuhn, Andrew Thompson Proteome Sciences Plc
P-284 EXPANDING THE MYCOBACTERIUM TUBERCULOSIS PHOSPHOPROTEOME CATALOGUE AND IDENTIFICATION OF TYROSINE-PHOSPHORYLATION THROUGH LABEL-FREE PHOSPHOPROTEOMIC ANALYSIS OF A CLINICAL ISOLATE Suereta Fortuin1, Gustavo de Souza2, Samantha Sampson1, Robin Warren1, Harald Wiker3, Nicolaas Gey v Pittius1, Nagarjuna Nagaraj4, Matthias Mann 1 Stellenbosch University 2 Olso University 3 Bergen University 4 Max Planck Institute
P-285 PHOSPHOPROTEOMIC ANALYSES REVEAL THAT GALECTIN-1 AUGMENTS THE DYNAMICS OF B-CELL RECEPTOR SIGNALING Hsin-Yi Wu1, Chih-Ming Tsai1, Tseng-Hsiung Su1, Chu-Wei Kuo1, Han-Wen Huang1, Cheng-Han Chung1, Chien-Sin Chen1, Kay-Hooi Khoo1 Yu-Ju Chen1 Kuo-I Lin1 1 Academia Sinica, Taipei, Taiwan
P-286 SIMPLIFIED AND MINIMIZED FRACTIONATION USING STAGETIPS FOR IN-DEPTH PROTEOME AND PHOSPHOPROTEOME ANALYSIS Jun Adachi, Kazunari Hashiguchi, Misako Sato, Kazuna Fukamizu, Takeshi Tomonaga National Institute Of Biomedical Innovation
P-287 IRON-TRIGGERED SIGNAL TRANSDUCTION IN THE PARASITIC PROTOZOAN TRICHOMONAS VAGINALIS Jung-Hsiang Tai1, Hong-Ming Hsu1, Fu-An Lee1, Shu-Hui Chen2 1 National Chen-Kung University
P-288 A PHOSPHOPROTEOMIC VIEW OF CHICKPEA EXTRACELLULAR MATRIX ILLUSTRATE COMBINATORIAL INTERPLAY OF PREDICTED AND UNEXPECTED COMPONENTS OF CELL WALL INTEGRITY SIGNALING IN PLANT Eman Elagamey, Kanika Narula, Arunima Sinha, Pooja Choudhary, Niranjan Chakraborty, Subhra Chakraborty National Institute Of Plant Genome Research
149 P-289 MASS-SPECTROMETRIC IDENTIFICATION OF AMPK PHOSPHOSITES IN RAT MITOCHONDRIAL FUMARATE HYDRATASE Sylvie Michelland1, 2, 3, Sarah Zorman4, 5, Malgorzata Tokarska-Schlattner4, 5, Michel Seve1, 2, 3, Uwe Schlalttner4, 5, Sandrine Bourgoin-Voillard1, 2, 3 1 Univ. Grenoble Alpes, IAB, PROMETHEE Proteomic Platform, F-38000, Grenoble, France 2 INSERM, IAB, PROMETHEE Proteomic Platform, F-38000, Grenoble, France 3 CHU de Grenoble, IAB, Institut de Biologie et de Pathologie, PROMETHEE Proteomic Platform, F-38000, Grenoble, France 4 Univ. Grenoble Alpes, Laboratory of Fundamental and Applied Bioenergetics, F-38000, Grenoble, France 5 INSERM, U1055, F-38000, Grenoble, France
P-290 EFFECTS OF A TOXOPLASMA GONDII ROP KINASE ON THE HOST CELL PHOSPHOPROTEOME Konstanze Schott, Kathryn Lilley, Jim Ajioka University Of Cambridge
P-291DEEP PROTEOME MAPPING OF MOUSE KIDNEY BASED ON OFFGEL PREFRACTIONATION REVEALS REMARKABLE PROTEIN POST- TRANSLATIONAL MODIFICATIONS Sameh Magdeldin1,2, Keiko Yamamoto1, Yutaka Yoshida1, Bo Xu1, Ying Zhang1, Hidehiko Fujinaka1, Eishin Yaoita1, John Yates3 Tadashi Yamamoto1 1 Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan 2 Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. 3 Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, United States
P-292 COMPLEMENTARY PROTEASES SUBSTANTIALLY EXPAND PHOSPHOPROTEOME COVERAGE Thin Thin Aye1,2, Piero Giansanti1,2, Mao Peng1,2, Henk van den Toorn1,2, Bas van Breukelen1,2, Albert J. R. Heck1,2 1 Biomolecular Mass Spectrometry And Proteomics Group 2 The Netherlands Proteomics Center
P-293 GLIOBLASTOMA PHOSPHOTYROSINE-CONTAINING PROTEINS IDENTIFIED WITH TWP-DIMENSIONAL WESTERN BLOTTING AND TANDEM MASS SPECTROMETRY Xianquan Zhan, Tianyao Guo, Maoyu Li, Xiaowei Wang Xiangya Hospital, Central South University
P-294 QUALITATIVE AND QUANTITATIVE PHOSPHOPROTEOMICS ANALYSIS OF CHICK RETINA OF TIO2-ENRICHED STRATEGY Bingjie Chen1,2, Fengjuan Yu1, King Kit Li1, Ka Man Chun1, Chuen Lam1, Chi Ho To1 1 The Hong Kong Polytechnic University, Hong Kong SAR, China 2 Sichuan University, Sichuan Province, China
150 P-295 MOTIF-BASED QUANTITATIVE PROTEOMICS FOR ABSOLUTE PHOSPHORYLATION STOICHIOMETRY MEASUREMENT Chia-Feng Tsai1,2, Yi-Ting Wang1, 3, Hsin-Yung Yen3, 4, Chih-Chiang Tsou5, Wei-Chi Ku7, Pei-Yi Lin1, Alexey I. Nesvizhskii5, Chi-Huey Wong4 Yasushi Ishihama6 Yu-Ju Chen1, 2 1 Institute of Chemistry, Academia Sinica, Taipei, Taiwan 2 Department of Chemistry, National Taiwan University, Taipei, Taiwan 3 Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan 4 Genomics Research Center, Academia Sinica, Taipei, Taiwan 5 Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, US 6 Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan 7 School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
P-296 ADAPTATION OF CELLULAR SIGNALING BY INTRINSICALLY ACTIVE P38 MAP KINASES Dganit Melamed1, Jonah Beenstock2, David Engelberg2, Arie Admon1 1 Technion-Israel Institute Of Technology 2 The Hebrew University of Jerusalem
P-297 PHOSPHOPEPTIDE ENRICHMENT USING SYNTHETIC BIOMIMETIC LIGANDS Iris L. Batalha1, Christopher R. Lowe2, Ana C. A. Roque1 1 Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal 2 University of Cambridge, Tennis Court Road, CB2 1QT, Cambridge, UK
P-298 PHOSPHODISTILLER: A WORKFLOW OF THE PHOSPHORYLATION QUALITY CONTROL BASED ON THE TANDEM MASS SPECTROMETRY DATA Chengpu Zhang, Jie Ma, Ning Li, Songfeng Wu, Ping Xu, Fuchu He, Yunping Zhu Beijing Proteome Research Center, Beijing, China
P-299 SIGNALLING NETWORK PLASTICITY IN RESPONSE TO CHRONIC CLASS I PI3K OR MTORC1/2 INHIBITION Edmund Wilkes1, Camille Terfve2, Julio Saez-Rodriguez2, Pedro Cutillas1 1 Barts Cancer Institute, Queen Mary University of London, UK 2 European Bioinformatics Institute-EMBL, Cambridge, UK
P-300 MAGNETITE-DOPED POLYDIMETHYLSILOXANE (PDMS) AS A SOLID PHASE SUPPORT FOR PHOSPHOPEPTIDE ENRICHMENT. Mairi Sandison2, Karina Tveen Jensen1, Frank Gesellchen2, Jonathan Cooper2, Andrew Pitt1 1 Aston University, Birmingham, UK 2 Glasgow University, Glasgow, UK
P-301 QUANTITATIVE PHOSPHOPROTEOMICS FOR BREAST CANCER VIA PHOSPHORYLATION BY AMPK Sachendra Kumar, Debnath Pal, Annapoorni Rangarajan Indian Institute Of Science
151 P-302 IMPROVED DETECTION OF MULTIPHOSPHORYLATED PEPTIDES USING NOVEL TIO2 BASED NANOMATERIALS Rudolf Kupèík, Jan Macák, Pavel Øehulka, Zuzana Bílková University of Pardubice, Faculty of Chemical Technology, Pardubice, Czech Republic
P-303 SEA URCHIN PHOSPHOPROTOEMICS REVEAL THE NEW LIGHTS ON EGG ACTIVATION Hongbo Guo1, Andrew Lugowski1, Ana Elisa Garcia-Vedrenne2, Cuihong Wan1, Anthony Morada2, Ruth Isserlin1, Kathy Foltz2, Andrew Emili1 1 University of Toronto, Toronto, ON, Canada 2 UCSB Marine Science Institute, Santa Barbara, CA, United States
P-304 QUANTITATIVE PHOSPHOPROTEOMICS OF SIGNALING PATHWAYS ACTIVATED BY HEPATITIS C VIRUS CORE PROTEIN AND TGF-Â USING A TRIPLE SILAC APPROACH Cosette Abdallah1, Nazha Sidahmed-Adrar1, Nassima Benzoubir1, Marie-Françoise Bourgeade1, François Le Naour1, Delphine Pflieger2 1 Inserm U785, 14 Avenue Paul Vaillant Couturier, 94800 Villejuif, France 2 LAMBE, CNRS UMR 8587, Université d’Evry Val d’Essonne, Boulevard François Mitterrand, 91025 Evry, France
P-305 PARTICULATE MATTER DEPHOSPHORYLATES EZRIN/RADIXIN/MOESIN (ERM) PROTEIN ON BEAS-2B CELL Moonhwan Choi1,2, Yungeun Ha1,2, Eunhye Nam1,2, Taiyoun Rhim1,2 1 Department Of Bioengineering, College Of Engineering, Hanyang University 2 Institute of Bioengineering and Biopharmaceutical Research, Hanyang University
P-306 IDENTIFICATION OF NEW PHOSPHORYLATION SITES IN KEY MAIZE C4 ENZYMES BY LIT-ORBITRAP MASS SPECTROMETRY Bruno M. Alexandre, Ana P. Farinha, Inês M. Luís, Nelson J.M. Saibo, M. Margarida Oliveira, Isabel A. Abreu Instituto Biologia Experimental e Tecnológica (iBET) and Instituto de Tecnologia Química e Biológica (ITQB) da Universidade Nova de Lisboa, Oeiras, Portugal
P-307 MONITORING KINOME ACTIVITIES USING THE HIGHLY SPECIFIC AND SENSITIVE SUBSTRATE PEPTIDES Naoyuki Sugiyama, Haruna Imamura, Pasrawin Taechawattananant, Dai Sakamoto, Masaki Wakabayashi, Yasushi Ishihama Graduate School of Pharmaceutical Sciences, Kyoto University
P-308 PLK2 SPECIFICITY AND SUBSTRATES IDENTIFICATION BY PROTEOME-DERIVED PEPTIDE LIBRARIES AND QUANTITATIVE PROTEOMICS Cinzia Franchin1,2, Luca Cesaro1, Lorenzo A. Pinna1,3, Mauro Salvi1, Giorgio Arrigoni1,2 1 University of Padova, Padova, Italy 2 Proteomic Center of Padova University, Padova, Italy 3 CNR Institute of Neurosciences, Padova, Italy
152 P-309 THE PHOSPHOPROTEOME OF JURKAT T-CELLS UPON COSTIMULATION WITH ANTI-CD3/ANTI-CD28 Tien Dung Nguyen1, 2, Oriol Vidal1, Oscar Gallardo1, Vanessa Casas1, Montserrat Carrascal1, Van Chi Phan2, Joaquin Abian1, 1 Proteomics Laboratory CSIC/UAB, Institute Of Biomedical Research Of Barcelona (IIBB), Spanish National Research Council (CSIC), Spain 2 Protein Biochemistry Laboratory, Institute of Biotechnology (IBT), Vietnam Academy of Science and Technology (VAST), Vietnam
P-310 QUANTITATIVE PROTEOMICS APPLIED TO THE STUDY OF THE MAMMALIAN CIRCADIAN PROTEOME AND PHOSPHOPROTEOME Maria S. Robles, Juergen Cox, Matthias Mann Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
P-311 EVALUATION OF PHOSPHOTYROSINE IMMUNOPRECIPITATION FOR LABEL-FREE PHOSPHOPROTEOMICS USING CANCER CELL LINE MODELS Inge De Reus1, Koen Van Der Mijn2, Robin Beekhof1, Sander R. Piersma1, Jaco C. Knol1, Thang V. Pham1, Henk Broxterman2, Henk MW Verheul2 Connie R Jimenez1 1 OncoProteomics Laboratory 2 Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
P-312 ROBUST TIO2-BASED ENRICHMENT FOR SINGLE-SHOT PHOSPHOPROTEOMICS; APPLICATION TO COLORECTAL CANCER CELL LINES REPRESENTING DIFFERENT SUBTYPES Sander R Piersma1, Inge De Reus1, Bharath Sampadi1, Mariette Labots2, Jaco C. Knol1, Thang V. Pham1, Henk MW Verheul2, Connie R Jimenez1 1 OncoProteomics Laboratory 2 Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
P-313 IS LESS ENOUGH? SCALING DOWN PROTEIN INPUT FOR PHOSPHOPROTEOMICS BASED TREATMENT SELECTION IN PATIENTS WITH ADVANCED SOLID TUMORS Mariette Labots1, Johannes C. Van Der Mijn1, Sander R Piersma2, Richard R. De Haas1, Inge De Reus2, Jaco C. Knol2, Thang V. Pham2, Nicole C.T. Van Grieken3 Gerrit A. Meijer3 Henk M.W. Verheul1 Connie R. Jiménez2 1 Department of Medical Oncology, VU University Medical Center 2 OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center Department of Pathology, VU University Medical Center
153 P-314 PHOSPHOPROTEOMICS OF A PANEL OF AML CELL LINES Carolien Van Alphen1,2, Jacqueline Cloos2, Sander R. Piersma1, Jaco C. Knol1, Thang V. Pham1, Gert J. Ossenkoppele2, Henk MW Verheul1, Jeroen JWM. Janssen2 Connie R. Jimenez1 1 OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands 2 Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, T he Netherlands
154 07 - New trends in biomarker discovery
P-315 DEVELOP A MALDI-IMAGING MASS SPECTROMETRY METHOD IN MOUSE SKIN TISSUE PEPTIDE DISTRIBUTION STUDY. Jiekai Yu1, Shu Zheng1, Hui Zhang2 1 Cancer Institute, The Second Affiliated Hospital, Zhejiang University School Of Medicine, Hanzhou, Zhejiang, China 2 Department of Chemistry, University of Nevada at Las Vegas,, Las Vegas, NV USA
P-316 POTENTIAL BIOMARKERS BETWEEN BURKHOLDERIA PSEUDOMALLEI WILD TYPE AND ITS RPON2 MUTANT STRAIN USING MALDI-TOF MASS SPECTROMETRY APPLICATION Kitima Sresanga, Suthamat Niyompanich, Sittiruk Roytrakul, Sumalee Tungpradabkul Mahidol University
P-317 RELATIONSHIP BETWEEN BIOMARKER DISCOVERY AND COLONY MORPHOLOGY OF BURKHOLDERIA PSEUDOMALLEI BY WHOLE-CELL MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY (MALDI-TOF MS) Suthamat Niyompanich1, Kitima Srisanga1, Sittiruk Roytrakul2, Sumalee Tungpradabkul1 1 Mahidol University, Bangkok, Thailand 2 National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Pathum Thani, Thailand
P-318 IDENTIFICATION OF POTENTIAL BIOMARKERS OF HEPATOTOXICITY BY PROTEOMIC ANALYSIS OF BLOOD PLASMA IN A LOWER VERTEBRATE EXPOSED TO ARSENIC Bimal Mohanty1, Sudeshna Banerjee1, Anil Sharma1, Sasmita Mohanty2, Deebendranath GuhaMazumder3 1 ICAR- Central Inland Fisheries Research Institute, Barrackpore, Kolkata, India 2 School of Biotechnology, KIIT University, bhubaneswar, India 3 DNGM Research Foundation, 37/C- Block B, New Alipore, Kolkata, India
P-319 LABEL-FREE QUANTITATIVE PROTEIN PROFILING OF VASTUS LATERALIS MUSCLE DURING HUMAN AGING Laetitia Theron1, Christophe Chambon1, Marine Gueugneau2, Cecile Coudy2, Didier Viala1, Astrid Bijlsma3, Andrea Maier4, Gillian Butler-Browne5 Daniel Béchet2 1 Inra PFEM, Theix, France 2 INRA UMR1019 UNH, Theix, France 3 Groene Hart Hospital, Gouda, The Netherlands 4 University Medical Center, Amsterdam, The Netherlands 5 Institut de Myologie UM76, GH Pitié-Salpétrière, Paris, France
155 P-320 A NOVEL APPROACH FOR PROCESSING LC - ION MOBILITY - MS METABONOMICS DATA SETS Giorgis Isaac1, Giuseppe Astarita1, Martin Palmer2, Mark Bennett3, James Langridge2, John Shockcor1, Andy Borthwick3 1 Waters Corporation, Milford, MA 2 Waters Corporation, Wilmslow, UK 3 Nonlinear Dynamics, Newcastle upon Tyne, UK
P-321 DEVELOPING A HIGH-THROUGHPUT, LABEL FREE TARGETED-MS APPROACH FOR VALIDATION OF PLASMA PROTEIN CONCENTRATIONS ASSOCIATED WITH DISEASE RISK. Richard T Blankley1,2, Christal Fisher1,2, Wanchang Lin1,2, Garth JS Cooper1,2, Jenny E Myers1,2, Richard D Unwin1,2 1 The University of Manchester, Manchester UK 2 Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
P-322 PROTEOMICS-DRIVEN SELECTIVE MITOCHONDRIAL TARGETING FOR TREATING ANXIETY DISORDERS Michaela Filiou1, Markus Nussbaumer1, Larysa Teplytska1, Mike Murphy2, Rainer Landgraf1, Chris Turck1 1 Max Planck Institute Of Psychiatry, Munich, Germany 2 MRC, Mitochondrial Biology Unit, Cambridge, UK
P-323 NOVEL BIOMARKERS OF ANDROGEN DEFICIENCY FROM SEMINAL PLASMA PROTEOMIC PROFILING USING HIGH-RESOLUTION MASS SPECTROMETRY. Giuseppe Grande1, Federica Vincenzoni2, Domenico Milardi3, Antonella Giampietro1, Irene Messana4, Laura De Marinis1, Alfredo Pontecorvi1, Riccardo Marana3 Massimo Castagnola2 1 Division Of Endocrinology And Metabolic Diseases, Università Cattolica Del S. Cuore - Rome 2 Institute of Biochemistry and Clinical Biochemistry, Università Cattolica Del S. Cuore - Rome 3 International Scientific Institute “PaoloVI”, Università Cattolica Del S. Cuore - Rome 4 Department of Life and Environmental Sciences, University of Cagliari
P-324 INCREASING DEPTH OF COVERAGE IN DATA INDEPENDENT ACQUISITION Christie Hunter1, Ben Collins2, Ludovic Gillet2, Ruedi Aebersold2 1 AB SCIEX 2 ETH Zurich
P-325 THE DISCUSSION ABOUT RESULTS FROM IMMUNOASSAYS AND TARGETED PROTEOMICS - NEVER-ENDING STORY OF THE QUANTIFICATION OF PROTEINS Alena Fucikova1, Helena Rehulkova2, Lenka Zidkova2, Pavel Rehulka1, Radek Pudil3, Jiri Stulik1 1 Institute Of Molecular Pathology, Hradec Kralove, Czech Republic 2 Faculty of Medicine, Hradec Kralove, Czech Republic 3 University Hospital, Hradec Kralove, Czech Republic
156 P-326 SPIKEMIX PEPTIDES – A NOVEL APPROACH FOR SYNTHETIC PREPARATION OF LOW COST & SMALL SCALE PEPTIDE POOLS FOR MS-BASED PROTEOMICS Karsten Schnatbaum1, Johannes Zerweck1, Maren Eckey1, Larry Eckler1, Holger Wenschuh1, Hannes Hahne2, Bernhard Kuster2, Christopher M. Colangelo3,4 Ulf Reimer1 1 JPT Peptide Technologies GmbH, Berlin, Germany 2 Technische Universitaet Muenchen, Chair of Proteomics and Bioanalytics, Freising, Germany 3 W.M. Keck Foundation Biotechnology Resource Laboratory, School of Medicine, Yale University, New Haven, CT, USA 4 Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA
P-327 TEAR PEPTIDOMICS: IDENTIFICATION OF TEAR NATURALLY OCCURRING PEPTIDES BY CID, HCD AND ETD Mikel Azkargorta1, Arantxa Acera2, Javier Soria2, Ibon Iloro1, Iraide Escobes1, Tatiana Suarez2, Felix Elortza1 1 CIC bioGUNE, Proteored-ISCIII, CIBERehd, Derio, Spain 2 Bioftalmik Applied Research, Derio, Spain
P-328 NEOPTERIN PLASMA LEVELS PREDICT INFECTION DEVELOPMENT IN ANEURYSMAL SUBARACHNOID HEAEMORRHAGE PATIENTS Leire Azurmendi1, Vincent Degos2, Natalia Tiberti1, Natacha Kapandji2, Paola Sanchez2, Asita Sarrafzadeh3, Louis Puybasset2, Natacha Turck1 Jean-Charles Sanchez1 1 University Of Geneva, Geneva, Switzerland 2 Pitié-Salpêtrière Teaching Hospital, Paris, France 3 Geneva University Hospitals, Geneva, Switzerland
P-329 SEARCH FOR NOVEL ALLERGEN OF HEN FS EGG ALLERGY USING WESTERN BLOT ANALYSIS Yui Shibata1, Kazuyuki Sogawa1, Mamoru Satoh2, Naoki Shimojo3, Fumio Nomura2 1 Department Of Biochemistry, School Of Life And Environmental, Azabu University 2 Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University 3 Department of Pediatrics, Graduate School of Medicine, Chiba University
P-330 INTEGRATION OF SWATH AND MRM FOR BIOMARKER DISCOVERY OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA Guixue Hou1,2, Quanhui Wang1,2, Xiaomin Lou2, Jin Zi1, Liang Lin1, Siqi Liu1,2 1 BGI-Shenzhen, Shenzhen, China 2 Beijing Institute of Genomics, CAS, Beijing, China
P-331 STOP ENZYMATIC ACTIVITY AND PRESERVE PROTEOME INTEGRITY OF TISSUE SAMPLES BY HEAT STABILIZATION Charlotta Göransson1, Ulla Sollenberg1, Mats Borén1 1 Denator AB, Uppsala, Sweden
157 P-332 DIFFERENTIAL MOBILITY SPECTROMETRY FOR GAS-PHASE FRACTIONATION INCREASES PROTEOME COVERAGE AND IMPROVES ION LIBRARY CREATION FOR SWATH™ ACQUISITION Antonio Serna Sanz1, Christie Hunter1 1 ABSciex
P-333 CRITICAL COMPARISON OF SAMPLE PREPARATION STRATEGIES FOR SHOTGUN PROTEOMIC ANALYSIS OF FORMALIN-FIXED, PARAFFIN-EMBEDDED SAMPLES Marcello Abbondio1, Alessandro Tanca1, Salvatore Pisanu1, Sergio Uzzau1, Daniela Pagnozzi1, Maria Filippa Addis1 Porto Conte Ricerche, Alghero, Italy
P-334 INVESTIGATING BIOLOGICAL VARIATION IN HUMAN HEPATOCYTES OF PHASE I AND II DRUG METABOLISM ENZYMES Christian Baumann1, Xu Wang2, Hui Zhang3, Christie Hunter4 1 AB SCIEX, Darmstadt, Germany 2 AB SCIEX, Framingham, MA 3 Pfizer, Groton, CT 4 AB SCIEX, Redwood Shores, CA
P-335 IMPROVING PREDICTION OF IVF SUCCESS - LOOKING FOR PUTATIVE BIOMARKERS IN IVF-MEDIA UPON EMBRYO CULTIVATION Tanja Panic-Jankovic1, Anna Lobas2, Mikhail Gorshkov2, Andreas Fichtenabum1, Jia Wan1, Wei-Qiang Chen1, Detlef Pietrowski3, Sonja Seyfert1 Rainer Schmid1 Goran Mitulovic1 1 Medical University Of Vienna-Clin. Inst. Of Lab. Medicine 2 Russian Academy of Science-INEP 3 Medical University Of Vienna-Clin. Dept. for Obstr. and Gynecology
P-336 HIGH-THROUGHPUT/HIGH ACCURACY PROTEIN BIOMARKER DISCOVERY FOR DEVELOPMENTAL NEUROTOXICITY AFTER INSECTICIDE EXPOSURE BY APPLICATION OF ISOBARIC REPORTER ION QUANTIFICATION (TMT10PLEX) IN COMBINATION WITH HCD-MS3 ACQUISITION Stephan Jung1, Christopher Lößner1, Stefan Selzer1, Saša Koncarevic1, Belén Gómez Giménez2, Marta Llansola2, Vicente Felipo2, Marieke Meijer3 Milou M. L. Dingemans3 Karsten Kuhn1 1 Proteome Sciences R&D 2 Centro de Investigacion Principe Felipe (CIPF), Valencia, Spain 3 Institute for Risk Assessment Sciences (IRAS), Utrecht, The Netherlands
P-337 NOVEL BIOMARKERS FOR BLADDER CANCER: EVALUATION OF ELISA ASSAY PERFORMANCE IN URINE Despina Chatziharalambous1, Vasiliki Lygirou1, Jerome Zoidakis1, Kim E.M. van Kessel2, Ellen C. Zwarthoff2, Antonia Vlahou1 1 Proteomics Laboratory, Biomedical Research Foundation, Academy Of Athens, Athens, Greece 2 Departments of Public Health and Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
158 P-338 DOWNSCALING TISSUES PROTEOMICS, TOWARD PRECIOUS FFPE TISSUE SAMPLES PREPARATION. APPLICATION TO EARLY EVENTS OF CERVIX CANCER DECIPHERING. Rémi Longuespée1, Gabriel Mazzucchelli1, Nicolas Smargiasso1, Dominique Baiwir2, Charles Pottier3, Marie Alice Meuwis4, Florence Quesada-Calvo4, Philippe Delvenne3 Edwin De Pauw1 1 Mass Spectrometry Laboratory, Systems Biology and Chemical Biology, GIGA-Research, University of Liège, Liège, Belgium 2 GIGA Proteomic Facilities, University of Liège, Liège, Belgium. 3 Department of Pathology, GIGA Cancer, University of Liège Hospital, Liège, Belgium. 4 HepatP-Gastroenterology and Digestive Oncology Department, GIGA-Research, University of Liège Hospital, Liège, Belgium.
P-339 DATA DEPENDENT VERSUS DATA INDEPENDENT ACQUISITION APPLIED TO SAMPLES OF DIFFERENT PROTEIN DYNAMIC RANGE Nicolas Smargiasso1, Gabriel Mazzucchelli1, Dominique Baiwir1, Edouard Louis2, Florence Quesada-Calvo2, Marie-Alice Meuwis2, Edwin De Pauw1, 1 University of Liege 2 University Hospital of Liege
P-340 PROFILING OF HUMAN PLASMA CLUSTERIN USING A GLYCOPROTEOMICS APPROACH TO DISCOVER POTENTIAL BIOMARKERS OF ALZHEIMER’S DISEASE Hui-Chung Liang1, Claire Russell1, Raymond Chung2, Chantal Bazenet2, Abdul Hye2, Simon Lovestone2, Ian Pike2, Malcolm Ward1 1 Proteome Sciences PLC, London, UK 2 King’s College London, London, UK
P-341 TIO2 ENRICHMENT REVEALS LOW-ABUNDANCE, CANCER-ASSOCIATED PROTEINS IN HUMAN SERUM Shibu Krishnan1, Annalisa Nicastri1, Caterina Gabriele1, Giovanni Cuda1, Marco Gaspari1 University Magna Graecia Of Catanzaro, Italy
P-342 A NEXT GENERATION PROTEOMIC APPROACH FOR BIOMARKER DISCOVERY LINKING MULTIPLEXED SINGLE BINDER ASSAYS TO MASS SPECTROMETRY (MS) FOR DIRECT MOLECULAR VERIFICATION AND INVESTIGATION OF CANDIDATE BIOMARKERS. Claudia Fredolini1, Maja Neiman1, Frauke Henjes1, Davide Tamburro2, Rui Branca2, Fredrik Edfors 1, Janne Lehtiö2, Mathias Uhlén 1 Peter Nilsson1 Jochen M. Schwenk1 1 SciLifeLab, KTH–Royal Institute of Technology, Sweden. 2 SciLifeLab,Karolinska Institute, Sweden.
159 P-343 DESCRIPTION OF BAL PROTEOME IN LUNG TRANSPLANT RECIPIENTS: OPTIMIZATION OF SAMPLE ANALYSIS AND COMPARISON WITH HEALTHY VOLUNTEERS Johanna Claustre1,2, Hélène Flamant-Waret1,3, Sandrine Bourgoin-Voillard1,3, Izabel Bérard1,3, Sylvia G Lehmann1,3, Candice Trocmé3,4, Bertrand Toussaint3,4, Karine Botturi-Cavaillès5,6 Antoine Magnan5,6 Laurent Nicod7 Christophe Pison2,3,8,9 Michel Sève 1 Univ. Grenoble Alpes, IAB, PROMETHEE Proteomic Plateform, F-38000 Grenoble, France 2 Clinique Universitaire de Pneumologie, CHU de Grenoble, Grenoble, France 3 Université Joseph Fourier, Grenoble, France 4 Laboratoire de Biochimie des Enzymes et des Protéines, CHU de Grenoble, Grenoble, France 5 Service de Pneumologie, CHU de Nantes - Université de Nantes, Nantes, France 6 Institut du Thorax - INSERM UMR1087/CNRS UMR6291, Nantes, France 7 8 Centre HospitalP-Universitaire Vaudois - Université de Lausanne, Lausanne, Switzerland 8 Laboratoire de Bioénergétique Fondamentale et Appliquée, INSERM 1055, Grenoble, France 9 European Institute of Systems Biology and Medicine, Lyon, France
P-344 IDENTIFICATION OF HUMAN TEAR FLUID BIOMARKERS IN DIFFERENT DRY EYE DISEASE SUBGROUPS USING LABEL-FREE QUANTITATIVE PROTEOMICS Natarajan Perumal1, Sebastian Funke1, Dominik Wolters1, Norbert Pfeiffer1, Franz Grus1 1University Medical Center Of Mainz, Mainz, Germany
P-345 IDENTIFICATION OF POTENTIAL ISCHEMIC STROKE BIOMARKERS THROUGH SECRETOME ANALYSIS OF A BRAIN ENDOTHELIAL CELL LINE USING SILAC Víctor Llombart1, Teresa García-Berrocoso1, Mar Hernández-Guillamón1, Joan Josep Bech1, Francesc Canals1, Joan Montaner1 1 Vall D’Hebron Institute Of Research (VHIR), Universitat Autònoma De Barcelona, Barcelona, Spain
P-346 IMMUNP-LASER MICRODISSECTION COUPLED TO LABEL-FREE PROTEOMICS FOR THE ANALYSIS OF HUMAN BRAIN CELLS TO IDENTIFY POTENTIAL STROKE BIOMARKERS Teresa García-Berrocoso1, Victor Llombart1, Virginie Licker2, Alexandre Hainard2, Héctor Huerga1, Francesc Canals3, Jean-Charles Sanchez2, Joan Montaner1 1 Vall d’Hebron Institute of Research, Universitat Autònoma de Barcelona, Barcelona, Spain 2 University Medical Center, University of Geneva, Geneva, Switzerland 3 Vall d’Hebron Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain
P-347 MALDI IMAGING MASS SPECTROMETRY IN SUBTYPING BREAST CANCER: A PILOT STUDY Barbara Cardinali1, Thomas W. Powers2, Richard R. Drake2, Benjamin A. Neely2, Franca Carli1, Aldo Profumo1, Lucia Del Mastro1 1 IRCCS AOU San Martino - IST, Genoa, Italy 2 Medical University of South Carolina, Charleston , SC, USA
P-348 DETECTION OF TEAR PROTEIN BIOMARKERS FOR DIABETIC RETINOPATHY SCREENING Eva Csosz1, Adrienne Csutak1, Gergo Kallo1, Zsolt Torok1, 2, Jozsef Tozser1 1 University Of Debrecen, Debrecen, Hungary 2 Astrid Research Ltd., Toronto, Canada
160 P-349 HIGH THROUGHPUT MRM TARGETED PROTEIN QUANTIFICATION USING MICRO LC Stephen Lock1, Saša Miladinovic2, Eike Loge1, Yulia Butscheid2, Oliver Rinner2 1 AB Sciex 2 Biognosys AG
P-350 QUANTIFYING DRUG INDUCED ORGAN INJURY BIOMARKERS ACROSS THE SPECIES BARRIER Bart Van Den Berg1, Frederik Weiss1, Hannes Planatscher1, Helen Hammer1, Thomas O Joos1, Oliver Poetz1 1 NMI
P-351 CROSS-SECTIONAL SALIVA PROTEOMICS REVEALS ASSOCIATIONS BETWEEN PROTEIN ABUNDANCE AND PERIODONTAL AND NON-PERIODONTAL PHENOTYPES Manuela Gesell Salazar1, Annette Murr2, Elke Hammer1, Julia Bischof2, Vishnu Mukund Dhople2, Birte Holtfreter3, Thomas Kocher2, Uwe Völker 1 1 Interfaculty Institute For Genetics And Functional Genomics, University Medicine Greifswald 2 Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, 3 University Medicine Greifswald
P-352 DATA INDEPENDENT ACQUISITION - PACIFIC – FACILITATES IN-DEPTH PHENOTYPE ANALYSIS OF IRRITABLE BOWEL SYNDROME Young Ah Goo1, Bao Tran1, David Goodlett1 1 University of Maryland
P-353 PREPARATION OF ANTIBODY COATED NANOPARTICLES FOR HIGH SPEED PROTEOMICS ANALYSIS Zoltán Nagy1, Dávid Nyul1, Melinda Andrási1, István Bányai1, András Pungor2 1 University Of Debrecen, Dept. Of Colloid And Environmental Chemistry 2 University of Debrecen, Dept. of Experimental Physics
P-354 MONOLITHIC COLUMNS WITH IMMOBILIZED TIO2 FOR TRAPPING PHOSPHOPEPTIDES FROM HUMAN-EMBRYP-SECRETED PROTEINS Andreas Fichtenbaum1, Wei-Qiang Chen1, Tanja Panic-Jankovic1, Urh Cernigoj2, Miloš Barut2, Andras Pungor3, Zoltan Nagy3, Goran Mitulovic 1,4 1 Medical University Of Vienna-Clinical Dept. Of Laboratory Medicine 2 BIA Separations, Ajdovšcina, Slovenia 3 University of Debrecen, Debrecen, Hungary 4 Medical University Of Vienna-Proteomics Core Facility
161 P-355 PATIENT-DERIVED MELANOMA CELL LINE PROFILING BY MULTIPHASE-CHIPLC COUPLED SWATH CORRELATES WITH SENSITIVITY TO MEK INHIBITION Christoph Krisp1, Robert Parker1, Matthew McKay1, Hao Yang2, Remco van Soest2, Mark Molloy1 1 Australian Proteome Analysis Facility 2 Eksigent, part of AB SCIEX
P-356 DEVELOPMENT OF DIAGNOSTIC BIOMARKERS FOR DIABETIC RETINOPATHY AT EARLY STAGES USING ABSOLUTE QUANTITATIVE PROTEOMIC METHOD Jonghwa Jin1, Kyunggon Kim1,3, Sohee Oh4, Sang Jin Kim2, Hyeong Gon Yu1, Taesung Park5, Misol Do1, Youngsoo Kim1,3 1 Departments of Biomedical Engineering Seoul National University, Gwanak-ro, Gwanak-gu, Seoul 151-747 Korea 2 Opthalmology Seoul National University, Gwanak-ro, Gwanak-gu, Seoul 151-747 Korea 3 Institute of Medical & Biological Engineering Seoul National University, Gwanak-ro, Gwanak-gu, Seoul 151-747 Korea 4 Medical Research Center, Seoul National University College of Medicine, 28 Yongon-Dong, Seoul 110-799 Korea. Department of Biostatistics 5 Eoul Metropolitan Government-Seoul National University Boramae Medical Center, 20 Borame-Ro 5-Gil, Dongjak-Gu, Seoup 156-707, Korea, Department of Statistics
P-357 AUTOANTIBODY PROFILING OF MENINGIOMAS TO IDENTIFY BIOMARKERS USING HUMAN PROTEOME ARRAYS Parvez Syed1, Sanjeev Kumar1, Darpan Malhotra1, Sanjeeva Srivastava1 Department of Biosciences and Bioengineering, Indian Institute of Technology-Bombay, Mumbai 400 076, India
P-358 CHARACTERIZATION OF PROTEIN ISOFORMS PREDICTIVE OF CANCER USING IMMUNP-AFFINITY CAPTURE AND FAST LC-MS. Antoine Lesur1, Lina Ancheva1, Sebastien Gallien1, Jan Van Oostrum1, Yeoun-Jin Kim1, Guy Berchem2, Bruno Domon1, 2Luxembourg Clinical Proteomics Center, Strassen, Luxembourg 2CRP-Sante, Strassen, Luxembourg
P-359 CHALLENGES OF BIOMARKER DISCOVERY IN HUMAN DISEASES IN DEVELOPING WORLD Shabarni Gupta1, Apoorva Venkatesh1, Sandipan Ray1, Sanjeeva Srivastava1 1Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
162 P-360 DEVELOPMENT OF NOVEL BIOMARKER COMBINATIONS FOR THE DIFFERENTIAL DIAGNOSIS OF LUNG CANCER AND LUNG DISEASES USING MULTIPLE REACTION MONITORING Yong-In Kim1, Jung-Mo Ahn1, Hye-Jin Sung1, Sang-Su Na1, Jaesung Hwang2, Yongdai Kim2, Je-Yoel Cho1 1 BK21 Plus And Research Institute For Veterinary Science, College Of Veterinary Medicine, Seoul 2 National University, Seoul, South Korea 3 College of Natural Sciences, Seoul National University, Seoul, South Korea
P-361 PROTEOME-WIDE STUDY OF NEW POTENTIAL CEREBROSPINAL FLUID BIOMARKERS FOR BIPOLAR DISORDER WITH MULTIPLEXED SEMI-QUANTIFICATION BY TANDEM MASS TAG (TMT-6) LABELING IN COMBINATION WITH HIGH-RESOLUTION LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY Jessica Holmén Larsson1, Johan Gobom2, Joel Jakobsson1, Mikko Hölttä1, Henrik Zetterberg1,2, Kaj Blennow1,2, Mikael Landén1,2 1 Institute of Neuroscience and Physiology, University of Gothenburg 2 Sahlgrenska University hospital, Gothenburg
P-362 INTEGRATED GENE AND PROTEIN TISSUE EXPRESSION ANALYSIS FOR ADJUVANT TREATMENT DECISIONS IN EARLY STAGE LUNG CANCER Ferdinando Cerciello1, Simona G. Codreanu2, Luis Araujo1, Joseph M. Amann1, Nilini S. Ranbaduge3, Owen E. Branson3, Selen A. Yilmaz1, Jie Zhang1 Daniel C. Liebler2 Kun Huang1 Michael A. Freitas1 Kevin R Coombes, Vicki H. Wysocki, David P. Carbone 1 The Ohio State University Medical Center, Columbus, OH, USA 2 Vanderbilt University School of Medicine, Nashville, TN, USA 3 The Ohio State University, Columbus, OH, USA
P-363 PROTEOMICS APPLICATION OF CLINICALLY ARCHIVED FORMALIN-FIXED PARAFFIN EMBEDDED TISSUES: QUALITY EVALUATION BY 2-D PAGE Katarina Davalieva1, Sanja Kiprijanovska1, Katerina Kubelka-Sabit2, Vanja Filipovski2, Momir Polenakovik1 1 Research Center For Genetics Engineering And Biotechnology 2 Clinical Hospital “Sistina”, Skopje, Republic of Macedonia
P-364 IDENTIFICATION OF CANDIDATE BIOMARKERS FOR CNS RELAPSE OF DIFFUSE LARGE B CELL LYMPHOMAS USING LABEL-FREE QUANTITATIVE PROFILING Emmanuelle Mouton-Barbosa1, Anne Gonzalez de Peredo1, Florence Roux-Dalvai1, Roxana Martinez-Pinna1, Caroline Le Gall2, Catherine Thieblemont3, Bernard Monsarrat1, Odile Schiltz1 1 CNRS/Institut De Pharmacologie Et De Biologie Structurale, Toulouse, France 2 Methodomics, Toulouse, France 3 Hôpital Saint-Louis, Paris, France
163 P-365 LOW ABUNDANT PROTEINS ENRICHMENT OF URINARY SAMPLES FROM NEFROLYTHIASIS PATIENTS UNDERGOING LITHOTRIPSY THERAPY: PROTEOMINER TECHNIQUE VS ACETONE PRECIPITATION FOR URINE PROTEOME ANALYSIS. Fabrizio Di Giuseppe1,2, Riviello Antonella1, Zezza Andrea3, Marilisa Sulpizio1,2, Enrica Eleuterio1,2, Piergustavo De Francesco3, Carmine Di Iliio1,2, Sandra Cicchittti1,2 Stefania Angelucci1,2 1 School of Medicine and Health, “University G. d’Annunzio”, Chieti-Pescara, Aging Research Center CeSI “University G. d’Annunzio” Foundation,CHIETI, Italy 2 Stem TeCh Group, CHIETI, Italy 3 Urinary Stones Lythotripsy Center, ASL Chieti-Pescara, CHIETI, Italy
P-366 MONITORING THE STATUS OF INFANTS BEING ON NURSING IN INCUBATORS BY URINE PROTEOME ANALYSIS. Natalia Starodubtseva1, Alexey Kononikhin1,2, Kseniya Krohina1, Anna Bugrova3, Irina Nikitina1, Igor Popov1,3, Oleg Ionov1, Dmitriy Degtyarev1 Genady Sukhih1 Eugene Nikolaev2,3 1 Research Center For Obstetrics, Gynecology And Perinatology, Moscow, Russia 2 Institute for Energy Problems of Chemical Physics RAS, Moscow, Russia 3 Emanuel Institute of Biochemical Physics RAS, Moscow, Russia
P-367 NEW PARKINSON’S DISEASE EARLY BIOMARKERS? A DYNAMIC INTERACTOME APPROACH TO BETTER ELUCIDATE DJ-1 ROLE IN OXIDATIVE STRESS Bruno Manadas1, 2, Sandra Anjo1, 4, Matilde Melo1, Liliana Loureiro1, 3, Lúcia Sabala1, 3, José Carvalho1, 4, Vera M. Mendes1, 2, Tiago Faria1 Pedro Castanheira2 Mário Grãos2 1 Center For Neurosciences And Cell Biology - University Of Coimbra, Portugal 2 Biocant - Biotechnology Innovation Center, Cantanhede, Portugal 3 University of Aveiro, Portugal 4 Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
P-368 MEASUREMENT OF GLYCOSYLATED ALPHA-FETOPROTEIN IMPROVES DIAGNOSTIC POWER OVER NATIVE FORM ON HEPATOCELLULAR CARCINOMA Hyunsoo Kim1, Kyunggon Kim2, Jonghwa Jin2, Sujong Yu3, Eunsun Jang3, Jung-Hwan Yoon3, Youngsoo Kim1,2, 1 Seoul National University / Biomedical Sciences 2 Seoul National University / Biomedical Engineering 3 Seoul National University College of Medicine / Internal Medicine
P-369 MULTIPLEXED QUANTIFICATION OF PRETERM INFANT PLASMA PROTEINS USING HEAVY PROTEIN STANDARDS AND MS-BASED IMMUNOASSAYS Benedikt Lang1, Bart H.J. van den Berg1, Christopher Pynn2, Dieter Stoll2, Martin Gamer3, Wolfgang Goepel4, Peter Schulz-Knappe3, Thomas O. Jooa1 Oliver Poetz1 1 NMI The Natural And Medical Sciences Institute At The University Of Tuebingen 2 University of Albstadt-Sigmaringen 3 Protagen AG 4 Univerversitätsklinikum Schleswig-Holstein
164 P-370 CHANGE IN BLOOD CAN BE MORE SENSITIVELY DETECTED IN URINE Youhe Gao1, Menglin Li1, Mindi Zhao1 Institute Of Basic Medical Sciences, Chinese Academy Of Medical Sciences
P-371 NOVEL BIOMARKER DISCOVERY FOR ACUTE MYOCARDIAL INFARCTION: PROTEOMIC ANALYSIS OF FORMALIN-FIXED PARAFFIN-EMBEDDED TISSUE FROM AUTOPSY Yu Kakimoto1, Shinji Ito2, Tatsuaki Tsuruyama2, Keiji Tamaki2, Motoki Osawa1 1 Tokai University, Kanagawa, Japan 2 Kyoto University, Kyoto, Japan
P-372 PROTEOME ANALYSIS AND COMPARATIVE STUDY OF NORMAL ENDOMETRIAL STEM CELLS, ENDOMETRIOSIS STEM CELLS AND BONE MARROW MESENCHYMAL STEM CELLS Saeed Heidari-Keshel1, Mostafa Rezaei-tavirani1, Maryam Ebrahimi1 Proteomics Research Center, Beheshti University Of Medical Sciences
P-373 QUANTITATIVE PROTEOMIC ANALYSIS OF VITREOUS IN DIABETIC RETINOPATHY USING SWATH Lei Zhou1,2,3, Choi Mun Chan4, Ignatius Chua1, Roger Beuerman1,2,3 1 Singapore Eye Research Institute 2 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 3 SRP Neuroscience and Behavioral Disorder, DUKE-NUS Graduate Medical School, Singapore, Singapore 4 Singapore National Eye Centre, Singapore
P-374 PROTEOSEPSIS: PROTEOMIC ANALYSIS OF PLASMA PROTEINS DURING THE COURSE OF SEPSIS. Alex Campos2, Ramón Díaz1, Antonia Odena1, Ricard Ferrer3, Antoni Artigas4, Eliandre Oliveira1 1 Parc Científic de Barcelona, Barcelona, Catalonia, Spain 2 Sanford-Burnham Medical Research Institute; La Jolla, California, USA 3 Hospital Universitari Mútua Terrassa, Terrassa, Catalonia, Spain 4 Hospital de Sabadell. Corporació Sanitària Parc Tauli. Sabadell, Catalonia, Spain
P-375 SUBREGIONAL PROTEOMIC ANALYSIS OF HIPPOCAMPI FROM PATIENTS WITH ALZHEIMER’S DISEASE Jae Ho Kim1, Julien Franck, Taewook Kang, Harry W Steinbusch, Rivka Ravid, Isidro Ferrer, Jong Shin Yoo, Michel Salzet, Isabelle Fournier, Young Mok Park 1 1Mass Spectrometry Research Center, Korea Basic Science Institute 2 Laboratoire de Spectrometrie de Masse Biologique Fondamentale et Applique 3 Graduate School of Analytical Science and Technology, Chungnam National University 4 Department of Translational Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University Medical Center 5 Brain bank Consultants 6 Institut de Neuropatologia, Servei Anatomia Patologica, IDIBELL-Hospital Universitari de Bellvitge
165 P-376 PROTEOME ALTERATION INDUCED BY DIFFERENT-SIZED SILVER NANOPARTICLES (AG NPS) IN AN INTESTINAL CP-CULTURE MODEL Tommaso Serchi1, Anastasia Georgantzopoulou1, Celine Leclercq1, Jenny Renaut1, Marcin Kruszewski2, Anna Lankoff2, Jean-Nicholas Audinot1, Cedric Guignard1 Lucien Hoffmann1 Arno Gutleb1 1 Centre de recherche public Gabriel Lippmann - Belvaux, Luxembourg 2 Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warszawa, Poland
P-377 IDENTIFICATION OF NEW POTENTIAL MARKERS OF PRETERM BIRTH IN AMNIOTIC FLUID Petra Domasinska1,2, Vojtech Tambor2, Marian Kacerovsky3, Juraj Lenco4, Bo Jacobsson5, Maria Hallingstrom5, Mark Raftery6, Marie Vajrychova4 Alexander Cegan1 1 University of Pardubice, Pardubice, Czech Republic 2 University Hospital Hradec Kralove, Hradec Kralove, Czech Republic 3 University Hospital and Medical Faculty in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic 4 University of Defence, Hradec Kralove, Czech Republic 5 Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden 6 University of New South Wales, Sydney, Australia
P-378 IDENTIFICATION OF HUMAN HEMOGLOBIN-ACETAMINOPHEN ADDUCT Maxim Anurov1, Yaroslav Dubrovsky1, Vladimir Babakov1 1 Research Institute Of Hygiene, Occupational Pathology And Human Ecology
P-379 ISOLATION AND IDENTIFICATION OF SERUM PEPTIDES - A USEFUL TOOL FOR IDENTIFICATION OF NOVEL DISEASE BIOMARKERS FOR ALZHEIMER’S DISEASE Dilek Inekci1, Yi Sun2, Zacharias Damholt2, Kim Henriksen1, Birte Svensson2, Susanne Jacobsen2, Ole Vilholm3, Per Hägglund2 1 Nordic Bioscience A/S 2 Systems Biology, Technical University of Denmark 3 Vejle Hospital
P-380 3D MALDI IMAGING OF MOUSE HEART AFTER MYOCARDIAL INFARCTION Dagmar Niemeyer1, Lena Hauberg-Lotte2, Wolfgang Dreher7, Judith Berger3, Janina Oetjen2, Dennis Trede9, Moritz Wildgruber8, Peter Maass4 Axel Walch6 Klaus Steinhorst5 1 Bruker Daltonik GmbH; Bremen, Germany 2 MALDI Imaging Lab, University of Bremen, Bremen, Germany 3 Fraunhofer MEVIS Project Group Image Registration, Lübeck, Germany 4 Center for Industrial Mathematics, Bremen, Germany 5 Steinbeis Innovation Center SCiLS Research, Bremen, Germany 6 Research Unit Analytical Pathology, HMGU München, Oberschleissheim, Germany 7 University of Bremen, Bremen, Germany 8 Klinikum Rechts der Isar, TU München, München, Germany 9 SCiLS GmbH, Bremen, Germany
166 P-381 IN-DEPTH IDENTIFICATION OF PROTEIN IMAGES BY COMBINING HIGH MASS RESOLUTION MALDI FTICR IMAGING AND HIGH PERFORMANCE QTOF NLC-MS/MS Pierre-Olivier Schmit1, Shannon Cornett2, Sergei Dikler2, Matt Willetts2 1 Bruker Daltonique S.A., Wissembourg, France 2 Bruker Daltonics Inc., Billerica, MA
P-382 PROTEOMIC PATTERNS IN THE NCI60 CANCER CELL COMPENDIUM COMPLEMENT GENOMIC FEATURES IN PREDICTIVE MODELING OF ANTICANCER DRUG SENSITIVITY Tiannan Guo1, Ching Chiek Koh1,2, Michael Menden3, Emanuel Goncalves3, Qing Zhong3, Peter Wild4, Julio Saez-Rodriguez4, Ruedi Aebersold1,5 1 Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Switzerland 2 Heidelberg University, Germany 3 European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) 4 Institute of Surgical Pathology, University Hospital Zürich, Zürich, Switzerland 5 Faculty of Science, University of Zurich, Zurich, Switzerland
P-383 PROTEOMIC LANDSCAPE OF THE HUMAN CHOROID-RPE Jessica Skeie1, Vinit Mahajan 1 1 University Of Iowa
P-384 SCREENING FOR NEW FIBROSIS BIOMARKERS IN RAT BRONCHOALVEOLAR LAVAGE FLUID Jacob Hull Kristensen1,2, Per Hägglund2, Birte Svensson2, Susanne Jacobsen2, Morten Karsdal1, Jannie Sand1, Diana Leeming1, 1 Nordic Bioscience, Herlev, Denmark 2 Technical University of Denmark, Kgs. Lyngby, Denmark
P-385 CHARACTERIZATION OF AMNIOTIC FLUID PEPTIDOME IN PPROM PREGNANCIES WITH INFECTIOUS AND INFLAMMATORY COMPLICATIONS Marie Vajrychova1, Long Dai Vu2, Vojtech Tambor2, Marian Kacerovsky2,3, Marek Link1, Juraj Lenco1 1 Faculty Of Military Health Sciences, University Of Defense, Hradec Kralove, Czech Republic 2 Biomedical Research Center, University Hospital Hradec Kralove, Czech Republic 3 Faculty of Medicine, Charles University in Prague, Hradec Kralove, Czech Republic
P-386 IN-DEPTH ANALYSIS OF THE HUMAN VITREOUS PROTEOME USING A RESIN DEPLETION-BASED METHOD: APPLICATION TO THE DISCOVERY OF NEW BIOMARKERS FOR PROLIFERATIVE DIABETIC RETINOPATHY. Cindy Salvisberg1, Jean-Antoine C Pournaras2, Alexandre Hainard3, Catherine Fouda1, Thomas J Wolfensberger2, Natacha Turck1 1 Medical University Center, Geneva, Switzerland 2 Jules Gonin Eye Hospital, University of Lausanne, Switzerland 3 Proteomics Core Facility, Medical University Center, Geneva, Switzerland
167 P-387 NEW APPROACH TO THYROID-ASSOCIATED ORBITOPATHY DISEASE IN TEARS BY QUANTITATIVE PROTEOMICS Maria De Los Angeles Graciá1, Simone Eperon2, Alexandre Hainard3, Cindy Salvisberg1, Mehrad Hamedani2, Natacha Turck1 1 Medical University Center, Geneva, Switzerland 2 Jules-Gonin Eye Hospital , Lausanne, Switzerland 3 Proteomics Core Facility, Geneva, Switzerland
P-388 REDOX-STATE OF PENTRAXIN 3 AS A NOVEL BIOMARKER FOR RESOLUTION OF INFLAMMATION AND SURVIVAL IN SEPSIS Xiaoke Yin1, Friederike Cuello1,2,3, Manu Shankar-Hari4,5, Ursula Mayr1, Melanie Marshall1, Gonca Suna1, Peter Willeit6,7, Sarah R. Langley1 Ajay M. Shah1 Manuel Mayr1 1 King’s BHF Centre, King’s College London 2 Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Centre, 3 University Medical Center Hamburg-Eppendorf, Hamburg, Germany 4 DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany 5 Critical Care Medicine, Guy’s and St Thomas’ NHS Foundation Trust, London, UK 6 Division of Asthma Allergy and Lung Biology, King’s College London, London, UK 7 Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK 8 Department of Neurology, Innsbruck Medical Univerisity, Innsbruck, Austria
P-389 PROTEOMICS OF RED BLOOD CELLS FROM PATIENTS WITH OBSTRUCTIVE SLEEP APNEA Amelia Feliciano1,2, Vesna Prosinecki1, Vukosava Milic Torres1, Bruno Alexandre1, Fátima Vaz1, Andreia Almeida1, Ana S. Carvalho1, Rune Matthiesen1 Atul Malhotra3 Paula Pinto2 Cristina Bárbara2 Deborah Penque 1 Instituto Nacional de Saude Dr Ricardo Jorge, Lisboa, Portugal and Centro Hospitalar Lisboa Norte (CHLN), Lisboa, Portugal 2 Centro Hospitalar Lisboa Norte (CHLN), Lisboa, Portugal 3 Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
P-390 SECOND-HAND TOBACCO SMOKE EFFECTS EVALUATED BY PROTEOMICS Solange Pacheco1,2, Sofia Neves1,2, Vukosava Milic Torres1, Fátima Vaz1, Rune Matthiesen1, Peter James2, Carlos Lopes3, Nelson Marçal3 Antonio Bugalho De Almeida3 Tânia Simões1 Deborah Penque1 1 Instituto Nacional de Saude Dr Ricardo Jorge, Lisboa, Portugal 2 Lund University, Medicon Village, S-223 81 Lund, Sweden. 3 Centro Hospital Lisboa Norte (CHLN), Lisboa, Portugal
P-391 DEEP PROTEOME PROFILING USING HR/AM SELECTED ION MONITORING AND DATA INDEPENDENT ACQUISITION ON THE ORBITRAP FUSION TRIBRID MS Claire Dauly1, Karima Chaoui2, Marlène Marcellin2, Anne Gonzalez-de-Peredo2, Odile Schiltz2, 1 Thermo Fisher Scientific 2 Institut de Pharmacologie et de Biologie Structurale
168 P-392 BRONCHOALVEOLAR LAVAGE FLUID PROTEIN PROFILE IN HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS Maneesh Bhargava1, Kevin Viken1, Sanjoy Dey1, Michael Steinback1, Baolin Wu1, Pratik Jagtap1, Peter Bitterman1, Mukta Arora1 David Ingbar1 Chris Wendt1 1 University Of Minnesota
P-393 SMFAP4 – A NOVEL BIOMARKER FOR GRADING AND MANAGEMENT OF HEPATITIS C INFECTION Thilo Bracht1, Christian Möllecken2, Gereon Poschmann3, Anders Schlosser5, Kai Stühler3, Helmut E. Meyer1, 4, Wolff H. Schmiegel2, Uffe Holmskov5 Grith Lykke Sorensen5 Barbara Sitek1 1 Medizinisches Proteom-Center, Ruhr-Universität Bochum, Germany 2 Department of Gastroenterology and Hepatology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum, Germany 3 Molecular Proteomics Laboratory, Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine- Universität Düsseldorf, Germany 4 Leibniz-Institut für Analytische Wissenschaften - ISAS e.V., Dortmund, Germany 5 Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark
P-394 AFFIMER ARRAYS FOR BIOLOGICAL AND BIOMARKER DISCOVERY Paul Ko Ferrigno1, Kit-Yee Tan1, Vincent Puard1, Qifeng Song2, 3, Paul Shadbolt1, Matt Johnson1 1 Avacta Life Sciences 2 University of Leeds 3 (Current) Johns Hopkins University
P-395 HIGH THROUGHPUT PROTEIN PURIFICATION: 235,000 PROTEINS A YEAR, AND COUNTING Paul Ko Ferrigno1, Paul Shadbolt1, Emma Branson1, Amanda Evans1, Katarzyna Gorczak1, Tony Kwok1, Ruth Lunn1, Matt Johnson1 1 Avacta Life Sciences
P-396 ROLE OF COMPLEMENT COMPONENTS IN RETINOPATHY OF PREMATURITY? Sonika Rathi1, Subhabrata Chakrabarti1, Subhadra Jalali, Ramesh Kekunaya, Suman Thakur, Rohit Budhraja, T Ramakrishna, Ch Mohan Rao, Inderjeet Kaur 1 Prof. Brien Holden Eye Research Centre 2 Smt. Kannuri Santhamma Centre For Vitreo? 3 Jasti V Ramanamma Children’s Eye Care Centre, L V Prasad Eye ? 4 Centre For Cellular and Molecular Biology Hyderabad, India.?
P-397 CHARACTERIZATION OF UROKINASE VIA ELECTROPHORESIS AND MASS SPECTROMETRY ANALYSES A. D´Amato1, P.G Righetti1, E. Fasoli1 1 Dep of CMIC “Giulio Natta”, Politecnico Di Milano, Via Mancinelli 7, 20131. Milano. Italy
169 P-398 STROMAL MARKERS OF BREAST CARCINOMA IDENTIFIED BY PROTEOMICS OF LASER MICRODISSECTED TISSUE Lavakumar A Reddy1, Leann Mikesh1, Christopher Moskulak1, Paola Zigrino2, Cornelia Mauch2, Jay W Fox1 1 University of Virginia School of Medicine, Departments of Microbiology, Immunology and Cancer 2 Biology; Radiology and Pathology, Charlottesville, VA USA 3 University of Cologne, Department of Dermatology, Cologne, Germany
P-399 POTENTIAL BIOMARKER DISCOVER OF THE WILSON’S DISEASE BY TOP-DOWN PROTEOMIC INVESTIGATION OF WHOLE SALIVA T. Cabras1, M. Sanna1, D. Fanni2, L. Demelia3, O. Sorbello3, F. Iavarone4, M. Castagnola4, G. Faa2 I. Messana1 1 Department of Life and Environmental Sciences, Biomedical Section. University of Cagliari, Monserrato Campus, Monserrato, Italy 2 Department of Surgery Sciences. University of Cagliari, Monserrato Campus, Monserrato, Italy 3 Department of Medical Sciences “M. Aresu”, AOU, University of Cagliari, Monserrato Campus, Monserrato, Italy 4 Biochemistry and Clinical Biochemistry Institute, Medicine Faculty, Catholic University of Rome, and 5 Institute of Chemistry of The Molecular Recognition CNR, Rome, Italy
170 08 - Non-human proteomic and food proteomics
P-400 RAPID DIRECT DETECTION OF THE MAJOR FISH ALLERGEN BY HIFU-SMIM Monica Carrera1, Benito Cañas2, Lorena Barros1, Jose M Gallardo1 1 Spanish National Research Council (CSIC), Vigo, Pontevedra, SPAIN 2 Complutense University (UCM), Madrid, SPAIN
P-401 QUANTITATIVE PROTEOME ANALYSIS OF THE ENDOSPERM OF DEVELOPING SEEDS OF JATROPHA CURCAS L. Mohibullah Shah1, Emanoella Soares1, Arlete Soares1, Paulo Carvalho2, Fabio Nogueira3, Gilberto Domont3, Francisco Campos1 1 Federal University Of Ceará, Fortaleza, CE, Brazil 2 Fundação Osvaldo Cruz, Curitiba, PR, Brazil 3 Universidade Federal do Rio de Janeiro, Rio de Janeiro, RB, Brazil
P-402 METABOLOMIC PROFILE IN XYLITOL INTOXICATION OF DOGS Mari Palviainen, Mari Vainionpää, Kati Hanhineva, Marja Raekallio, Heini Lahtinen, Outi Vainio University Of Helsinki
P-403 PROTEOMIC ANALYSIS OF ESCAMOLES (LIOMETOPUM APICULATUM MAYR, LARVAE), THE “MEXICAN CAVIAR”: A NEW MODEL FOR DISEASE RESEARCH? José A. Huerta-Ocampo1, Sara García-Muñoz2, Alberto Barrera-Pacheco1, Alicia Grajales-Lagunes2, Ana Paulina Barba de la Rosa1 1 IPICyT, Instituto Potosino De Investigación Científica Y Tecnológica A.C. 2 Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí
P-404 PROTEIN PROFILING ACROSS THE DEVELOPMENT OF THE ORIENTAL FRUIT FLY Chiou Ling Chang, MaryAnn Villalun USDA-ARS
P-405 PROTEOMICS OF RICE AND COCHLIOBOLUS MIYABEANUS FUNGAL INTERACTION: INSIGHT INTO PROTEINS AT INTRACELLULAR AND EXTRACELLULAR SPACES Sun Tae Kim1, Jingni Wu2, Jin Young Kim1, Yu Ji Kim1, Soon Jae Kwon1, Ha Ram Oh1 1 Department of Plant Bioscienc, Pusan National University 2 Department of Plant Microbe Interactions, Max-Planck Institute for Plant Breeding Research
P-406 COMPARATIVE METABLOMICS AND PROTEOMICS ANALYSIS REVEAL CHANGES OF ISOFLAVONE PATHWAY FLOW IN SEED COAT OF GLYCINE MAX CV. MALLIKONG AND MALLIKONG MUTANT Sun Tae Kim, Yu Ji Kim, Soon Jae Kwon, Yong Chul Kim, In Soo Choi Department Of Plant Bioscience, Pusan National University
171 P-407 INVESTIGATION OF NUTRIENT DEFICIENCY RESPONSES OF POTATO ROOTS USING PROTEOMICS AND METABOLOMICS APPROACHES Stephanie Kaspar1, Anna Maria Jozefowicz2, Nadja Arens2, Andrea Matros2, Manuela Peukert2, Stefanie Döll2, Hans-Peter Mock2, 1 Bruker Daltonik GmbH, Bremen 2 1Institute of Plant Genetics & Crop Plant Research, Gatersleben
P-408 QUANTITATIVE LABEL-FREE SHOTGUN PROTEOMIC ANALYSIS OF RED AND WHITE GRAPEVINE EXPOSED TO HIGH AND LOW TEMPERATURE STRESSES. Iniga S George, Paul A Haynes, Robert D Willows Macquarie University, Sydney, NSW, Australia
P-409 UNDERSTANDING NUTRIENT-RESPONSIVE PROTEIN AND METABOLIC NETWORKS IN FOOD CROPS Kanika Narula, Sudip Ghosh, Shubhendu Shekhar, Priyanka Jawa, Niranjan Chakraborty, Subhra Chakraborty National Institute Of Plant Genome Research
P-410 PROTEOME ANALYSIS OF PROGRAMMED CELL DEATH FOLLOWING SPINAL CORD INJURY Teresa Muñoz De Galdeano, Rodrigo Martinez MAza, Ángela de Águila Sánchez, Manuel Nieto Diaz, David Reigada Prado, Marcos Caballero López, Rosa Navarro Ruíz, Verónica M. Darde, Gemma Barroso García, Ana Gallardo Escobar Hospital Nacional De Paraplejicos
P-411 PEPTIDOMICS OF YOUR SARDINIAN SNACK: ENRICHMENT AND CHARACTERIZATION OF PEPTIDES IN ARTISANAL CHEESE AND BEER Salvatore Pisanu, Grazia Biosa, Roberto Anedda, Luca Pretti, Sergio Uzzau, Daniela Pagnozzi, Maria Filippa Addis Porto Conte Ricerche, Alghero, Italy
P-412 GEL-BASED PROTEOMIC ANALYSIS OF RNA-DEPENDENT PROTEIN STABILITY IN ESCHERICHIA COLI Chan Park, Keun Na, Baik-Lin Seong Yonsei University, Seoul, Korea
P-413 IDENTIFICATION OF CHITINOLYTIC PROTEINS IN THE SECRETOME OF CELLVIBRIO JAPONICUS Tina Tuveng, Magnus Arntzen, Johan Larsbrink, Phil Pope, Gustav Vaaje-Kolstad, Vincent Eijsink Norwegian University Of Life Sciences
172 P-414 POTEOMIC MILK AND BLOOD ANALYSIS OF GREEK DOMESTIC SHEEP BREEDS Athanasios Anagnostopoulos1, Aggeliki Katsafadou1, 2, Marouko Tsagkari1, George Arsenos3, John Skoufos4, Athina Tzora4, Spiros Karkampounas5, George Fthenakis2 George Tsangaris1 1 Biomedical Research Foundation Of The Academy Of Athens, Athens, Greece 2 University of Thessaly, Karditsa, Greece 3 Aristotle University of Thessaloniki, Thessaloniki, Greece 4 Technological Educational Institute of Epirus, Arta, Greece 5 University of Ioannina , Ioannina, Greece
P-415 MULTIPLE REACTION MONITORING ANALYSIS REVEALS CHANGES IN S1P-S1 PRECEPTOR AXIS FOLLOWING SPINAL CORD INJURY Angela Del Águila, Verónica M. Darde, Gemma Barroso, Ana Gallardo-Escobar, David Reigada, Teresa Muñoz-Galdeano, Rosa Navarro-Ruiz, Marcos Caballero-López, Rodrigo M Maza, Manuel Nieto-Diaz Hospital Nacional De Paraplejicos (SESCAM)
P-416 DE NOVO SEQUENCING AND QUANTITATIVE PROTEOMICS IN A NON-SEQUENCED SPECIES AS A WAY TO DISCOVER NEW ANTI-OBESITY MECHANISMS Margaux Benhaim-Delarbre1, Georg Tascher1, Mikko Hürlimann2, Alain Van Dorsselaer1, Pierre Bize2, Fabrice Bertile1 1 Institut Pluridisciplinaire Hubert Curien, CNRS, Université de Strasbourg; France 2 Institute of Biological and Environmental Sciences, University of Aberdeen; Scotland
P-417 APPLICATION OF CESI-MS ON SILAC-BASED QUANTITATIVE PROTEOMICS Herbert Sarg1, Klaus Faserl1, Leopold Kremser1, Martin Müller2, David Teis2, Bettina Sarg1 1 Innsbruck Medical University, Biocenter, Division of Clinical Biochemistry 2 Innsbruck Medical University, Biocenter, Division of Cell Biology
P-418 IDENTIFICATION OF WELFARE BIOMARKERS IN PIGS USING PERIPHERAL MONONUCLEAR CELLS (PBMCS) AND DIFFERENTIAL GEL ELECTROPHORESIS (DIGE) Daniel Valent, Laura Arroyo, Lourdes Criado, Francesca dell’Orco, Anna Bassols Universitat Autonoma De Barcelona
P-419 MINING OF PROTEINS INVOLVED IN NUTRITION AND TRANSDIFFERENTIATION IN BOVINE SKELETAL MUSCLE Hong-Gu Lee, U-Suk Jung, Jae-Sung Lee, Sang-Bum Lee, Min-Jeong Kim, Seung-Woo Jeon Konkuk University
P-420 PROTEOMIC ANALYSIS OF ARTHROBACTER SP. MWB-30, OIL-BIODEGRADING MICROBE ISOLATED FROM CRUDE-OIL CONTAMINATED SEASHORE Jonghyun Kim1, Soo Jung Kim1, Hyung-Yeel Kahng2, Seung Il Kim1, Young-Ho Chung1 1 Korea Basic Science Institute 2 Sunchon National University
173 P-421 THE NUTRACEUTICAL POTENTIAL OF QUERCUS ILEX L. REVEALED BY PROTEOMIC ANALYSIS OF ACORNS AND ROOTS. IMPACT OF THE DROUGHT STRESS. Lyudmila Simova-Stoilova1, Cristina Romero-Rodríguez2, Jose Valero-Galvan3, Rosa Sanchez2, Jesús Jorrín-Novo2 1 Institute Of Plant Physiology And Genetics, Sofia, Bulgaria 2 University of Cordoba, Cordoba, Spain 3 Autonomous University of Ciudad Juárez, Ciudad Juarez, Chihuahua, Mexico
P-422 PROTEOMICS APPLIED TO OENOLOGY, CHARACTERIZATION OF AUTOCHTHONOUS WINE YEAST STRAINS Eugenia Muñoz-Bernal, Maria C. Bernal, Jesus Cantoral, Francisco J. Fernandez-Acero Universidad De Cadiz
P-423 PROTEOMICS ANALYSIS OF BOTRYTIS CINEREA SIGNALING CASCADES: THE MEMBRANOME Eva Liñeiro, Jesus Cantoral, Francisco J. Fernandez-Acero Universidad De Cadiz
P-424 PROTEOMIC ANALYSIS OF CARDIAC TISSUE FROM RESISTANCE TRAINED RATS REVEALS CHANGES COMPATIBLE WITH HEART FAILURE Patricia Dantas1, Maisa Sakata1, Juliana Brandão1, Regina Watanabe1, Fernando Bizerra1, Vander Neves2, Vinicius Guzzoni2, Fernanda Marcondes2 Dulce Casarini1 Tatiana Uchiyama1 1 Federal University of São Paulo - UNIFESP. São Paulo, Brazil. 2 State University of Campinas - UNICAMP. São Paulo, Brazil.
P-425 SEMINAL PLASMA PROTEOMES OF RABBITS, BOARS AND BULLS AND THEIR ASSOCIATIONS WITH SPERM PARAMETERS. Arlindo Moura1, Veronica Cadavid1, Joao Paulo Rego1, Josy Alencar-Arruda1, Jorge Martins1, Aderson Viana-Neto1, Thiago Andrade1, Frederico Moreno2 Ana Cristina Monteiro-Moreira2 Renato Moreira2 1 Federal University of Ceara, Fortaleza, CE, Brazil 2 The University of Fortaleza (Unifor), Fortaleza, CE, Brazil
P-426 LACTOBACILLUS REUTERI SUB-PROTEOME STUDY TO ELUCIDATE UPTAKE, METABOLISM AND RELEASE OF SELENIUM FOR NUTRACEUTICAL APPLICATION Enrica Pessione1, Erika Mangiapane1, Alessandro Pessione1, Eugenio Galano2, Ryszard Lobinski3, Angela Amoresano2 1 Department of Life Sciences and Systems Biology, University of Turin, Turin , Italy 2 Department of Chemical Sciences, University of Naples “Federico II”, Napoli , Italy 3 LCABIE UMR5254, Technopôle Hélioparc Pau Pyrénées, France
174 P-427 TYPE I COLLAGEN COMPOSITION IN THE BONY FISH DANIO RERIO Assunta Gagliardi1, Claudia Landi1, Roberta Gioia2, Alessandro Armini1, Silvia Carra3, Sergey Leikin4, Shannon Fisher5, Ruggero Tenni2 Franco Cotelli3 Antonio Rossi2 Antonella Forlino2 Luca Bini, Laura Bianchi 1 University of Siena, Siena, Italy 2 University of Pavia, Pavia, Italy 3 University of Milano, Milan, Italy 4 NICHD/NIH, Bethesda, Maryland, USA 5 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
P-428 DYNAMIC CHANGES OF CONA-ENRICHED URINARY PROTEINS IN A FOCAL SEGMENTAL GLOMERULOSCLEROSIS RAT MODEL Mindi Zhao, Youhe Gao Institute Of Basic Medical Sciences, Chinese Academy Of Medical Sciences/Peking Union Medical College
P-429 PROTEOMIC IDENTIFICATION OF POTENTIAL LIVER BIOMARKERS IN AYU, PLECOGLOSSUS ALTIVELIS AS AN AGING ANIMAL MODEL Wei-Jung Chen1, Chih-Yun Chao1, Wei-Chen Tsai1, Yi-Lin Chen1, Chai-Ching Lin1, Hong-Young Yan2 1 National Ilan University, Ilan City, Taiwan 2 Marine Research Station, Academia Sinica, Jiaoshi, Ilan County, Taiwan
P-430 UNDERSTANDING THE INTERACTION OF ORGANISMS WITH THEIR BIOLOGICAL ENVIRONMENT – INITIATIVE ON MULTI ORGANISM PROTEOMES (IMOP) Andreas Tholey1, Sabine Schrimpf2, Emöke Bendixen3 1 Systematic Proteome Research And Bioanalytics, Christian-Albrechts-Universität Kiel, Germany 2 Institute of Molecular Life Sciences, University of Zurich, Switzerland 3 Department of Molecular Biology and Genetics, Aarhus University, Denmark
P-431 A VALIDATED METHOD FOR COW MILK DETECTION AND QUANTIFICATION IN BAKERY PRODUCTS BY LC-MS/MS. Elena Acquadro1, Davide Corpillo1, Cristina Lamberti2, Maria Gabriella Giuffrida2, Lucia Decastelli3, Marco Arlorio4, Carlo Ricciardi5, Garino Cristiano4 1 ABLE Biosciences- Bioindustrypark Silvano Fumero, Colleretto Giacosa, Torino, Italy 2 CNR ISPA c/oBioindustrypark Silvano Fumero, Colleretto Giacosa, Torino, Italy 3 Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D`Aosta, Torino, Italy 4 University of Piemonte Orientale A. Avogadro, Novara, Italy 5 DISAT, Politecnico, Torino, Italy
175 P-432 PHENOTYPING CHICKEN MALE FERTILITY BY INTACT CELL MALDI-TOF MASS SPECTROMETRY Laura Soler Vasco1, Aurore Thèlie1, Valérie Labas1,2,3,4, Isabelle Grasseau1,2,3,4, Ana-Paula Teixeira-Gomes1,2,3, Grégoire Harichaux1,2,3,4, Elisabeth Blesbois1,2,3,4 1 INRA Val de Loire, Nouzilly, Tours, France 2 CNRS, Nouzilly, Tours, France 3 Université François Rabelais de Tours, Tours, France 4 IFCE, Institut Français du Cheval et de l’Equitation, Nouzilly, Tours, France
P-433 CHANGES IN THE PROTEIN PROFILES OF PLASMA MEMBRANE PREPARATIONS FROM BETA VULGARIS ROOTS AS AFFECTED BY FE DEFICIENCY Elain Gutierrez Carbonell1, Daisuke Takahashi2, Sabine Lüthje3, Matsuo Uemura4, Javier Abadía1, Ana Flor López-Millán1 1 Aula Dei Experimental Station (CSIC) 2 United Graduate School of Agricultural Sciences (Iwate University), Morioka, Japan 3 University of Hamburg (Biocenter Klein Flottbek), Hamburg, Germany 4 Cryobiosystem Research Center, Faculty of Agriculture (Iwate University), Morioka, Japan
P-434 PROTEOMIC STUDY OF BOVINE ENDOMETRIAL CELL STIMULATED WITH LPS Cristian Piras1, Alessio Soggiu1, Guo Yongzhi 2, Patrice Humblot2, Isabella Alloggio1, Michele De Canio1,4, Andrea Urbani3,4, Luigi Bonizzi1 Paola Roncada1,3,5 1 Department Of Veterinary Science And Public Health, University Of Milan 2 Division of Reproduction, Departement of Clinical Sciences,Swedish University of Agricultural Sciences, Uppsala, Sweden 3 Fondazione Santa Lucia – IRCCS, Rome, Italy 4 Dipartimento di Medicina Sperimentale e Chirurgia, Università degli Studi di Roma “Tor Vergata Istituto Sperimentale Italiano L. Spallanzani, Milano 5 Spallanzani Technologies srl, Milano
P-435 META-OMICS ANALYSIS TO INVESTIGATE MICROBIAL CONSORTIUM IN CHEESE PRODUCTION Paola Roncada1,2, Alessio Soggiu2, Emøke Bendixen3, Cristian Piras2, Isabella Alloggio2, Luigi Bonizzi2 1 Istituto Sperimentale Italiano L. Spallanzani, Milano, Italy 2 Department of Veterinary Science and Public Health, University of Milan, Milano, Italy 3 Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark
P-436 PROTEOMIC APPROACH TO INVESTIGATE THE ESCHERICHIA COLI MEMBRANE PROTEOME IN SEVERE ENVELOPE STRESS CONDITIONS. Sara Motta1, Alessandra Martorana2, Dario Di Silvestre1, Anna Maria Agresta1, Paola Sperandeo2, Alessandra Polissi2, Pierluigi Mauri1 1 Institute of Biomedical Technologies, National Research Council, Segrate, Milan, Italy 2 Department of Biotechnology and Biosciences, University of MilanP-Bicocca, Milan, Italy
176 P-437 PROTEOMIC INSIGHTS INTO SULFUR METABOLISM IN THE HYDROGEN-PRODUCING HYPERTHERMOPHILIC ARCHAEON THERMOCOCCUS ONNURINEUS NA1 Yoon-Jung Moon1, Joseph Kwon1, Sung-Ho Yun1, Hye Li Lim1, Sung Gyun Kang2, Jung-Hyun Lee2, Seung Il Kim1, Young-Ho Chung1 1 Korea Basic Science Institute 2 Korea Institute of Ocean Science and Technology
P-438 A PROTEOMIC APPROACH UNRAVELS GENOTYPE DIFFERENCES IN GRAPEVINE RESISTANCE TO DOWNY MILDEW Ana Varela Coelho1, Andreia Figueiredo2, Joana Martins1, Mónica Sebastiana2, Filipa Monteiro2, Maria Salomé Pais2 1 Instituto De Tecnologia Química E Biológica António Xavier - UNL 2 Functional & Integrative Genomics (BioFIG), Science Faculty of Lisbon University, 1749-016 Lisboa, Portugal
P-439 PROTEOMICS TO UNRAVEL MECHANISMS OF NANOPARTICLE TOXICITY Francisco Cabello-Hurtado1, Jesús V. Jorrín-Novo2, Marie-Andrée Esnault1, Stéphane Cordier3, Fabien Grasset3 1 UMR UR1-CNRS 6553 Ecobio, Mechanisms at the Origin of Biodiversity Team, University of Rennes1, Campus de Beaulieu, 35042 Rennes, France 2 Agricultural and Plant Biochemistry, Proteomics Research Group, Dept. of Biochemistry and Molecular Biology, University of Córdoba, Campus de Rabanales, 14071 Córdoba, Spain 3 UMR UR1-CNRS 6226 Institut des Sciences Chimiques de Rennes, Solid State Chemistry and Materials Group, University of Rennes1, Campus de Beaulieu, 35042 Rennes, France
P-440 PROTEOMICS OF THE AGING LIVER MITOCHONDRIA Madalina Oppermann1, Jenny Ho1, Loïc Dayon2, John Corthésy2, Antonio Núñez Galindo2, Umberto De Marchi2, Rosa Viner3, Martin Hornshaw1 Andreas Wiederkehr2 Martin Kussmann2 1 Thermo Fisher Scientific, Europe 2 Nestlé Institute of Health Sciences, Lausanne, Switzerland 3 Thermo Fisher Scientific, USA
P-441 CHARACTERIZATION OF PROTEINS AND PUTATIVE FUNCTIONAL PATHWAYS IN ROTIFER ENCYSTED DORMANT EMBRYOS (RESTING EGGS) Tamar Ziv1, Nadav Denekamp2, Vered Chalifa-Caspi3, Inbar Plaschkes3, Arie Admon1, Esther Lubzens1 1 Technion-Israel Institute Of Technology, Haifa, Israel 2 Israel Oceanographic and Limnological Research, Haifa, Israel 3 Bioinformatics Core Facility, National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel
177 P-442 CHARACTERIZATION OF PLANT GLYCATED PROTEOME AND ITS CHANGES DURING AGEING AND UNDER ENVIRONMENTAL STRESS CONDITIONS Elena Lukasheva1, Dominic Brauch2, Tatiana Bilova2, Juliane Mittasch3, Carsten Milkowski3, Natalia Osmolovskaya1, Ludgar Wessjohann4, Andrej Frolov2 1 St. Petersburg University, Faculty of Biology and Soil Science, Department of Plant Physiology and Biochemistry 2 Universität Leipzig, Faculty of Chemistry and Mineralogy, Institute of Bioanalytical Chemistry 3 Martin Luther University Halle-Wittenberg, Interdisciplinary Center for Crop Plant Research (IZN) Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry
P-443 LEVELS OF CHEMOSENSORY AND ODORANT-BINDING PROTEINS FROM CATERPILLAR SALIVA ARE AFFECTED BY HOST PLANT AND IMMUNE CHALLENGE Dorothea Rutishauser1,2, Maria de la Paz Celorio-Mancera4, A. Jimmy Ytterberg3, Niklas Janz4, Roman A. Zubarev1,2 1 Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Sweden 2 Science for Life Laboratory, Sweden 3 Karolinska Institute, Department of Medicine, Sweden 4 Stockholm University, Department of Zoology, Sweden
P-444 FRACTIONATION OF TOTAL, SOLUBLE AND INSOLUBLE PROTEINS IN GLOEOBACTER VIOLACEUS PCC7421 Soo Jung Kim1, 4, Jung Ha Choi1, Kun Cho2, Joseph Kwon1, Young Hwan Kim2, Kwang Hwan Jung3, Young-Ho Chung1 1 Division of Life Sciences, Korea Basic Science Institute, Daejeon 2 Mass Spectrometry Research Center, Korea Basic Science Institute, Ochang 3 Department of Biological Sciences, Sogang University 4 Department of Biological Sciences, Korea Advanced Institute of Science and Technology
P-445 UNDERSTANDING PHYTOCHELATIN PROFILE IN NICOTIANA TABACUM UNDER CD, CU AND AS STRESS: A STEP TOWARDS PHYTOREMEDIATION-APPLICATIONS Rita Laires1, Luisa Louro Martins2, Miguel P. Mourato2, Ana Varela Coelho1 1 Instituto De Tecnologia Química E Biológica António Xavier - UNL 2 UIQA, Instituto Superior de Agronomia, Universidade de Lisboa, Lisboa, Portugal
P-446 THE PROTEOME OF OLIVE AND THE INVISIBLE PROTEOME OF OLIVE OILS A. D´Amato1, C. Esteve2, M.L Marina2, M.C Garcia2, P.G Righetti1, E. Fasoil1 1 Dep of CMIC “Giulio Natta”, Politecnico Di Milano, Via Mancinelli 7, 20131. Milano. Italy. 2 Dep of Analytical Chemistry, University of Alcalá, Ctra. Madrid-Barcelona,. Alcalá De Henares. Madrid. Spain.
178 P-447 PROTEOMIC FINGERPRINTING OF ITALIAN APERITIFS Elisa Fasoli1, Alfonsina D’Amato1, Mara Colzani2, Giancarlo Aldini2, María Jesús Lerma-García3, Ernesto Francisco Simó-Alfonso3, Pier Giorgio Righetti1 1 Politecnico Di Milano, Department of Chemistry, Materials and Chemical Engineering “Giulio Natta” (CMIC), Via Mancinelli 7, Milano 20131, Italy 2 Department of Pharmaceutical Sciences, Università Degli Studi Di Milano 3 Department De Química Analítica, Facultat De Química, Universitat De València
P-448 PROTEOMIC CHANGES OF CERVICAL ADENOCARCINOMA CELLS (HELA) INDUCED BY THE TREATMENT WITH A SNAKE VENOM DERIVED PHOSPHOLIPASE A2 (BOTHROPS MARMORATUS) Jessica Kele A Macedo1,2,3, Mariana S. Castro1,2, Jay W. Fox3 1 Laboratory of Biochemistry and Protein Chemistry, Dept. of Cell Biology/IB, University of Brasilia, Brasi- lia/DF, Brazil 2 Lab. of Toxinology, Dept. of Physiological Sciences/IB, University of Brasilia, Brasilia/DF, Brazil 3 Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virgínia, United States
P-449 EXTENDED-SPECTRUM ??-LACTAMASE (ESBL) PRODUCING GRAM (-) ENTEROBACTERIACEAE STRAINS IN FOODS FROM TURKEY Haydar Özp?nar1,2, Ísmail Hakk1 Tekiner1, Aysel Özp?nar3 1 Food Engineering Department of ?stanbul Ayd?n University 2 Food Safety and Nutritional Sciences Department of ?stanbul Ayd?n University 3 Medical Biochemistry Department of Ac?badem School of Medicine
179 09 - Immunobiology and cell signalling
P-450 MASS SPECTROMETRY ANALYSIS OF RAT ALVEOLAR MACROPHAGES NR8383 SECRETOMES: EFFECT OF PROPROTEIN CONVERTASE 1/3 (PC1/3) DOWN-REGULATION. Marie Duhamel1, Franck Rodet1, Maxence Wisztorski1, Antonella Raffo Romero1, Michel Salzet1, Isabelle Fournier1 1 Laboratoire Spectrométrie De Masse Biologique Fondamentale Et Appliquée, Université Lille 1
P-451 COMPARISON OF IMMEDIATE RENAL DYSFUNCTION IN SPLIT AND PARTIAL LIVER TRANSPLANTATION VERSUS FULL SIZE LIVER TRANSPLANTATION IN SHIRAZ TRANSPLANT CENTRE Nazila Hassanabadi1, Pooria Ghadiri2, Maryam Sharifian3, Mohammad Mahdi Sagheb4, Saman Nikeghbalian5, Ali Malek-Hosseini6, Jamshid Roozbeh7, Abbas Mohammadi8 1 Faculty Of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran 2 Faculty of medicine, Student Research committee Shiraz university of Medical Sciences 3 Department of Neurology, Resident of neurology, Shiraz university of Medical Sciences 4 Department of Nephrology,Faculty Of Medicine, Shiraz university of Medical Sciences 5 Department of liver Transplantation ,Faculty Of Medicine, Shiraz university of Medical Sciences 6 Department of liver Transplantation ,Faculty Of Medicine, Shiraz university of Medical Sciences 7 Nephrology,Faculty Of Medicine, Shiraz university of Medical Sciences 8 Faculty Of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran
P-452 INSIGHTS INTO SIGNALLING PATHWAYS INVOLVED IN ALLERGIC IMMUNE RESPONSES THROUGH DIFFERENTIAL PROTEOME AND SECRETOME ANALYSIS OF DENDRITIC CELLS. Christina Ramsauer1, Lisa Weilnböck1, Michael Wallner1, Jutta Horejs-Höck1, Christian G. Huber1 1 University of Salzburg, Salzburg, Austria
P-453 A LABEL FREE APPROACH TO CHARACTERIZE THE INTERACTION OF HUMAN NATURAL KILLER CELLS WITH POLARIZED MACROPHAGES. Andrea Petretto1, Inglese Elvira1, Lavarello Chiara1, Bellora Francesca2, Bottino Cristina2, 1 Core Facilities - Laboratorio di Spettrometria di Massa e Proteomica, Istituto Giannina Gaslini, Genoa, Italy 2 Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genoa Italy.
P-454 IMMUNOMODULATORY MECHANISM OF A NOVEL POLYSACCHARIDE FROM LENTINULA EDODES Xiaofei Xu1, Xuewu Zhang1 1 South China University Of Technology
180 P-455 THE ANALYSIS OF HUMAN SPERM PROTEOME BY MEANS OF POLYCLONAL ANTISPERM ANTIBODIES. Karolina Nowicka-Bauer1, Marzena Kamieniczna1, Jan Cibulka2, Zdenka Ulcova-Gallova2, Maciej Kurpisz1 1 Institute Of Human Genetics Polish Academy Of Sciences 2 Department of Gynecology and Obstetrics, Charles University and Faculty Hospital, Pilsen
P-456 IL-2 AND IL-15 SIGNALING NETWORKS: SIMILAR BUT NOT IDENTICAL Nerea Osinalde1, Irina Kratchmarova1 Center Of BioInformatics, University Of Southern Denmark
P-457 STAIN FREE TOTAL PROTEIN QUANTITATION – A METHOD FOR GREATER RELIABILITY IN WESTERN BLOT LOADING CONTROLS Ning Liu1, Matt Hammond1, Jonathan Kohn1, Kenneth Oh1, Patricia Piatti1 1 BiP-Rad Laboratories
P-458 EARLIER DIAGNOSIS AND PREDICTION OF ALLERGY TO PEANUT ALLERGENS USING ADVANCED TECHNIQUE IMMUNOCAP 250 Amrat Khorana1, Jacqueline Smith1, 2, Ruta Furmonaviciene1 1 De Montfort University, Leicester, Leicestershire, United Kingdom 2 Northampton General Hospital NHS Trust, Northampton, Northamptonshire, United Kingdom
P-459 OPTIMIZED ANTIBODY PANEL FOR MULTIPLEXED DETECTION OF AKT/MAPK PHOSPHORYLATION EVENTS BY WESTERN BLOTTING April Baugher1, Tom Davies1, Christian Frisch1, Lei Li1, Shane Peterson1, Sricharan Bandhakavi1, Ning Liu1, David Peretz1 1 BiP-Rad Laboratories
P-460 COOPERATION OF LIVER CELLS REVEALED BY CELL-SPECIFIC GENES Ying Jiang1, Peng Wu, Yanyan Li, Chen Ding, Jun Qin, Fuchu He 1 Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
P-461 LARGE-SCALE, LABEL-FREE QUANTITATIVE PROTEOMIC CHARACTERIZATION OF REGULATORY VERSUS CONVENTIONAL T LYMPHOCYTES ISOLATED FROM MOUSE Anne Gonzalez De Peredo1, Fanny Duguet1, Marlène Marcellin1, Céline Colacios2, Abdelhadhi Saoudi2, Bernard Monsarrat1, Odile Schiltz1, 1 CNRS/Institute de Pharmacologie et de Biologie Structurale 2 INSERM/Centre de Physiopathologie Toulouse Purpan
181 P-462 PHOSPHOPROTEOMIC CHARACTERIZATION OF INFLUENZA A VIRUS INFECTED HUMAN PRIMARY MACROPHAGES Tuula Nyman1, Sandra Söderholm1,2, Denis Kainov3, Tiina Öhman1, Susumu Imanishi4, Garry Corthals4, Vittorio Fortino2, Dario Greco2 Tero Aittokallio3 Sampsa Matikainen2 1 Institute Of Biotechnology 2 Finnish Institute of Occupational Health 3 Institute for Molecular Medicine Finland 4 Turku Centre for Biotechnology
P-463 INFLAMMATORY BOWEL DISEASES - A CLINICAL PROTEOMICS STUDY SEEKING TO IDENTIFY THE UNDERLYING BIOLOGICAL TRIGGERS. Tue Bennike1, Thomas Carlsen1, Lau Sennels1, Vibeke Andersen2, Svend Birkelund1, Allan Stensballe1 1 Aalborg Universitet 2 University of Southern Denmark
P-464 IMMUNE DYSREGULATION LEADS TO PATHOLOGICAL NEOVASCULARISATION IN SUBJECTS WITH RETINOPATHY OF PREMATURITY Inderjeet Kaur1, Sonika Rathi1, Subhabrata Chakrabarti1, Subhadra Jalali2,3, Ramesh Kekunaya3, Suman Thakur4, Rohit Budhraja4, T Ramkrishna4 Ch Mohan Rao4 1 Prof Brien Holden Eye Research Centre, L V Prasad Eye Institute 2 Smt. Kannuri Santhamma centre for Vitreo Retinal Diseases, L V Prasad Eye Institute 3 Jasti V Ramanna Children’s Eye Care Centre, L V Prasad Eye Institute 4 Centre for Cellular and Molecular Biology, Hyderabad, India
P-465 2-DE-BASED PROTEOMIC ANALYSIS OF THE PLATELET CLEC-2 SIGNALLING CASCADE FOCUSING ON THE PI 6-11 RANGE Irene Izquierdo1, Isaac Rosa1, Esteban Guitián1, Johannes A. Eble2, Ángel García1 1 Universidad De Santiago De Compostela 2 University of Münster
P-466 LIPOPOLYSACCHARIDE-INDUCED CYTOKINES/CHEMOKINES SECRETOME IN HUMAN NEUROBLASTOMA SH-SY5Y CELLS: A MODEL FOR NEUROINFLAMMATION Nadezhda Rogovskaya1, Yaroslav Dubrovsky1, Petr Beltiukov1, Andrey Radilov1, Vladimir Rembovsky1, Vladimir Babakov1 1 Research Institute Of Hygiene, Occupational Pathology And Human Ecology
182 P-467 THE SURFACEOME OF NAÏVE T CELLS – A PROTEOMIC SYSTEMS APPROACH TO IDENTIFY NEW CELL SURFACE MARKERS IN EARLY T CELL ACTIVATION Anke Graessel1, Katharina Dietz1, 2, Stefanie Hauck3, Christine von Toerne3, Michael Schindler4, Herwig Koppensteiner4, Carsten Schmidt-Weber1, 2, Kathrin Suttner1, 2 1 ZAUM - Center of Allergy and Environment, Technical University and Helmholtz Center Munich, Munich, Germany 2 DZL- member of the German Center for Lung Research 3 Research Unit Protein Science, Helmholtz Center Munich, Munich, Germany 4 Institute of Virology, Helmholtz Center Munich, Munich, Germany
P-468 PROTEOMIC PROFILE OF ISLETS OF LANGERHANS IN PRE-DIABETIC NOD MICE. Inne Crèvecoeur1, Dieter Rondas1, Wannes D’Hertog1, Etienne Waelkens2, Valborg Gudmundsdottir3, Soeren Brunak3, Chantal Mathieu1, Lut Overbergh1 1 Laboratory for Clinical and Experimental Endocrinology, KU Leuven, Belgium 2 Laboratory for Protein Phosphorylation and Proteomics, KU Leuven, Belgium 3 Department of Disease Systems Biology, University of Copenhagen, Denmark
P-469 CHEMICAL PROTEOMICS HIGHLIGHTS PROTEIN KINASES INVOLVED IN MACROPHAGE DIFFERENTIATION AND FUNCTION Erik Richter1, Manuela Harms1, Katharina Ventz1, Jörg Mostertz1, Falko Hochgräfe1 1 Junior Research Group Pathoproteomics - University Of Greifswald
P-470 A SILAC-PHOS STRATEGY TO DETERMINE THE PMA-PKCA DEPENDENT SIGNALING MAP Severine Gharbi1, Rosana Navajas1, Antonio Ramos-Fernandez2, Raquel Arcos1, Isabel Merida1, Juan Pablo Albar1 1 Spanish National Biotechnology Centre (CNB)/CSIC, Madrid, Spain 2 Proteobotics SL, Spanish National Biotechnology Centre (CNB)/CSIC, Madrid, Spain
P-471 ANALYSIS OF THE SURFACEOME OF CYTOTOXIC T LYMPHOCYTES IN DIACYLGLYCEROL KINASE ZETA KO MICE Gonzalo Martínez1, Severine Gharbi1, Elena Andrada1, Isabel Merida1, Juan Pablo Albar1 1 National Center For Biotechnology/CSIC
183 10 - REDOX proteomics and mitochondrial biology
P-472 GLOBAL-SCALE NITRATION IDENTIFICATION AND RELATIVE QUANTITATION USING STA- BLE ISOTOPE-CODED NITROTYROSINE INTERNAL STANDARDS Stanley M. Stevens Jr.1, Alison R. Fertig1, Joao P. C. Pinho1, Craig P. Dufresne2, Harris Bell-Temin1 1 University Of South Florida 2 Thermo Fisher Scientific
P-473 REDOX PROTEOMICS AND METABOLOMICS TO UNDERSTAND THE HEALTHY EFFECT OF OMEGA-3 FISH LIPIDS Lucía Méndez1, Gabriel Dasilva1, Monica Carrera1, Manuel Pazos1, José Manuel Gallardo1, Isaac Rodríguez2, Rafael Cela2, Isabel Medina1 1 Spanish National Research Council (CSIC), Vigo, Pontevedra, SPAIN 2 University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
P-474 A NEW METHOD FOR DETECTING AND IDENTIFYING CARBONYLATED BIOMOLECULES: APPLICATION TO IN VITRO OXIDIZED TAU PROTEIN BY MALDI-MASS SPECTROMETRY. Lyna Sellami1, Claude Villard2, Matthew Openshaw1, Jean-Michel Brunel2, Pascale Barbier2, Omar Belgacem1, Daniel Lafitte2 1 Kratos Analytical 2 Aix-Marseille University
P-475 NOVEL INSIGHTS INTO THE DYNAMIC DEEP REDOXOME Aleksandra Binek1, Inmaculada Jorge Cerrudo1, Emilio Camafeita1, Elena Bonzón-Kulichenko1, Juan Antonio López1, Alicia Izquierdo2, Antonio Martínez-Ruiz2, Borja Ibáñez1 Mario Nuño Ayala1 Jesús Vázquez1 1 Centro Nacional De Investigaciones Cardiovasculares (CNIC), Madrid, Spain 2 Hospital Universitario de la Princesa, Madrid, Spain
P-476 PROTEOMIC ANALYSES REVEALED RESTORING OF THE VALOSIN CONTAINING PROTEIN IN THE ISCHEMIA-REPERFUSION INJURED RAT HEPATIC CELLS BY KAEMPFEROL ENRICHED ETHANOLIC EXTRACT FROM DRY STIGMATA OF CROCUS SATIVUS L. (SAFFRON) Grzegorz Bazylak1, Tung-Ho Wu2,3, Pei-Wen Wang4, Tai-Long Pan4, Yann-Lii Leu5, Yang-Chang Wu2 1 Nicolaus Copernicus University, Faculty of Pharmacy, Bydgoszcz, POLAND 2 Kaohsiung Medical University, College of Pharmacy, Kaohsiung,Taiwan, ROC 3 Kaohsiung Veterans General Hospital, Department of Surgery, Kaohsiung,Taiwan, ROC 4 Chang-Gung University, School of Traditional Chinese Medicine,Taoyuan,Taiwan, ROC 5 Chang-Gung University, College of Medicine,Taoyuan, Taiwan, ROC
184 P-477 TARGETTED MASS SPECTROMETRY METHODS FOR DETECTING OXIDATIVE POST-TRANSLATIONAL MODIFICATIONS. Karina Tveen Jensen, Ana Reis, Corinne Spickett, Andrew Pitt Aston University
P-478 THE REDOX INTERACTOME OF PTEN: CELLULAR AND PROTEIN SPECIFIC CHANGES Ivan Verrastro1, Karina Tveen Jensen1, Rudiger Woscholski2, Corinne Spickett1, Andrew Pitt1 1 Aston University, Aston Triangle, Birmingham, UK 2 Imperial College London, London, UK
P-479 UNCOVERING THE TRACES OF OXIDATIVE DAMAGE IN OBESE PATIENTS María Gómez-Serrano1, Emilio Camafeita2, Juan A. López2, Eva García-Santos1, Jesús Vázquez2, Belén Peral1 1 Instituto De Investigaciones Biomedicas, Alberto Sols (CSIC-UAM), Madrid, Spain 2 Proteomics Unit. Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
P-480 FUNCTIONAL PROTEOMICS ANALYSIS OF THE MAIN GATEWAY TO MITOCHONDRIA: DECODING THE MITOCHONDRIAL IMPORTOME IN TRYPANOSOMA BRUCEI Silke Oeljeklaus1, Christian Peikert1, Jan Mani2, André Schneider2, Bettina Warscheid1, 1 Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany 2 Faculty of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
P-481 A NOVEL METHOD FOR ENRICHMENT OF CYSTEINE-CONTAINING PEPTIDES STARTING FROM LOW AMOUNT OF BIOLOGICAL MATERIALS Giuseppe Palmisano, Honggang Huang, Martin Pedersen, Martin Rossel Larsen University Of Southern Denmark
P-482 ANALYSIS OF CHMEICAL OXIDATION OF A DUAL SPECIFICITY PHOSPHATASE BY MASS SPECTROMETRY. Stuart Calimport, Karina Tveen Jensen, Corinne Spickett, Andrew Pitt Aston University, Birmingham, UK
P-483 PROFILING THE CYSTEINE REDOX PROTEOME: CHEMICAL VS. METABOLIC LABELING Shakir Shakir, Giovanni Chiappetta, Iman Haddad, Gennaro Chiappetta, Joelle Vinh National Cancer Institute, Naples, Italy
P-484 TETRAHYDROBIOPTRIN PROTECTED CARDIAC FUNCTION AND STRUCTURE IN TYPE 2 DIABETIC RAT HEART VIA MODULATION OF MITOCHODRIAL PROTEOME Jin Han, Hyoung Kyu Kim, Tae Hee Ko, In Sung Song, Sung Hun Jeong, Sung Ryul Lee, Thi Thu Vu, Nari Kim, Kyung Soo Ko, Byoung Doo Rhee, Sora Lee 1 National Research Laboratory For Mitochondrial Signaling Laboratory, Department Of Physiology, 2 College Of Medicine, Cardiovascular And Metabolic Disease Center, Inje University
185 P-485 REDOX PROTEOMICS FOR EVALUATION OF PERITONEAL DIALYSIS INDUCED OXIDATIVE STRESS Silvia Tarantino1, Anton Lichtenauer1,2, Anja Wagner2, Rebecca Herzog1,2, Christoph Aufricht1, Klaus Kratochwill1,2 1 Medical University Of Vienna, Vienna, Austria 2 Zytoprotec GmbH, Vienna, Austria
P-486 LARGE SCALE PROTEOMICS REVEALS REGULATION OF MULTIPLE SIGNALLING PATHWAYS IN FIBROBLASTS FROM MAPLE SYRUP URINE DISEASE CLASSIC PATIENTS Paula Fernandez Guerra1, Lei Cheng2, Rune Isak Dupont Birkler1, Robert A. Fenton2, Magdalena Ugarte3, Pilar Rodriguez Pombo3, Peter Bross1, Johan Palmfeldt1 1 Aarhus University and Aarhus University Hospital, Aarhus, Denmark 2 Aarhus University, Aarhus, Denmark 3 Centro de Biología Molecular-SO, UAM-CSIC, Centro de Investigación en Red de Enfermedades Raras, (CIBERER), IDIPAZ, Universidad Autónoma Madrid, Madrid, Spain
P-487 MITOCHONDRIAL PROTEOME CHANGES IN ETHE1-DEFICIENT MICE:INDICATION OF METABOLIC IMBALANCE Navid Sahebekhtiari1, Carlo Viscomi2, Massimo Zeviani2, Niels Gregersen1, Johan Palmfeldt1 1 Research Unit For Molecular Medicine, Aarhus University And Aarhus University Hospital, Denmark 2 Division of Molecular Neurogenetics, Foundation ‘C Besta’ Institute of Neurology, Milano, Italy
P-488 THIOL REDOX PROTEOMICS IN NITRIC OXIDE-INDUCED NEURAL STEM CELLS PROLIFERATION AND NEUROGENESIS Ana I. Santos1,2,3, Alicia Izquierdo-Alvarez4, Elena Ramos4, Elena Bonzón-Kulichenko5, Nuria Sánchez4,6, Bruno P. Carreira1, Ana S. Lourenço1,2,3, Dorinda M. Silva2,3 Tamara Villa-Piña4 Pablo Hernansanz-Agustín4,7 Anabel Marina6 Jesús Vázquez, Caetana M. Carvalho, Ines M. Araujo, Antonio Martínez-Ruiz 1 Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal 2 University of Algarve, Faro, Portugal 3 IBB - Institute for Biotechnology and Bioengineering, Centre for Molecular and Structural Biomedicine, Faro, Portugal 4 Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP) 5 Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain 6 Centro de Biología Molecular Severo Ochoa, CSIC-Universidad Autónoma de Madrid, Madrid, Spain 7 Universidad Autónoma de Madrid and Instituto de Investigaciones Biomédicas Alberto Sols, Madrid, Spain
P-489 COUPLING OCSILAC WITH SUBCELLULAR PROTEIN FRACTIONATION FOR CYSTEINE-REDOXOMICS Giovanni Chiappetta, Shakir Shakir, Joelle Vinh USR3149 CNRS/ESPCI-ParisTech
186 P-490 NEW FRONTIERS IN BACTERIAL INFECTION: THE ‘TARGET’ MITOCHONDRIA Alessio Soggiu1, Michele De Canio2, Cristian Piras1, Cristina Lecchi1, Fabrizio Ceciliani1, Valerio Bronzo3, Luigi Bonizzi1, Andrea Urbani2 Paola Roncada4 1 Department Of Veterinary Science And Public Health, University Of Milan, Milano, Italy 2 Dipartimento di Medicina Sperimentale e Chirurgia, Università degli Studi di Roma “Tor Vergata”, Roma, Italy 3 Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, University of Milano, Milano, Italy 4 Istituto Sperimentale Italiano L. Spallanzani, Milano, Italy
P-491 MITOCHONDRIA PROTEIN REPERTOIRE ADAPTATION IN ANIMAL MODELS OF AMIOTROPHIC LATERAL SCLEROSIS Viviana Greco1,2, Alida Spalloni2, Cristian Piras3, Paola Roncada3,4, Nicola B. Mercuri1,2, Patrizia Longone2, Andrea Urbani1,2 1 University of Rome “Tor Vergata”, Rome, Italy 2 Santa Lucia Foundation, Rome, Italy 3 Dipartimento Di Scienze Veterinarie E Sanità Pubblica , DIVET, Università Degli Studi Di Milano 4 Istituto Sperimentale Italiano Lazzaro Spallanzani, Milano
P-492 CHARACTERIZATION OF DRUG RESISTANCE BY NOVEL DATA INDEPENDENT ANALYSIS METHODS Michael Blank1, Ryan Bomgarden2, Ryan Jacobs3, Jason Fong3, Neelu Puri3, Andreas Huhmer1, John Rogers2, Rosa Viner1 1 ThermoFisher Scientific, San Jose, CA 2 Thermo Fisher Scientific, Rockford, IL 3 University of Illinois at Chicago, Rockford, IL
P-493 ANALYSIS OF THE THIOL REDOX PROTEOME OF HYPOXIC TREATED HUH7 CELLS AND POST-ISCHEMIC REPERFUSION MOUSE LIVER Armando Moreno, Fernando J. Corrales Hepatology and Gene Therapy. Proteomics Laboratory. CIMA, University of Navarra. 131008 Pamplona, Spain
187 11 - Mapping the Human Proteome
P-494 MONOCLONAL ANTIBODY AND RELATED PRODUCT CHARACTERIZATION UNDER NATIVE CONDITIONS USING A BENCHTOP EXACTIVE PLUS EMR MASS SPECTROMETER Yue Xuan1, François Debaene2, Johann Stojko2, Alain Beck3, Alain Van Dorsselaer2, Sarah Cianférani2, Maciej Bromiski1 1 ThermoFisher Scientific, Bremen, Germany 2 Institut Pluridisciplinaire Hubert Curien (IPHC), University of Strasbourg, Strasbourg, France 3 Centre d’Immunologie Pierre Fabre (CIPF), Saint Julien En Genevois, France
P-495 SIMPLIFIED MONOCLONAL ANTIBODY CHARACTERIZATION BY MIDDLE-DOWN/UP STRATEGY Hillel Brandes1, Xiaoning Lu1 1 Sigma-Aldrich Corp.
P-496 MIGRATION ASSOCIATED PROTEINS IN HUMAN CORNEAL EPITHELIAL CELLS (HCEC) AND ITS ROLE IN WOUND REPAIR Shamim Mushtaq1, Meraj Zahra2, Nikhat Siddiqui2 1 Department Of Biochemistry, Ziauddin University 2 Department Of Biochemistry, University of Karachi
P-497 HIGH-MOLECULAR-MASS PROTEOMICS BY TWP-DIMENSIONAL GEL ELECTROPHORESIS WITH AGAROSE AND POLYACRYLAMIDE HYBRID GELS IN THE SECOND DIMENSION Masamichi Oishi1 1 Kitasato University School Of Science
P-498 UNDERSTANDING THE STRUCTURAL DETERMINANTS FOR THE SELECTIVE INHIBITION OF SNAKE VENOM METALLOPEPTIDASES Viviane Bastos1, Surza Rocha1, Francisco Gomes-Neto1, Eladio Sanchez2, Teresa Escalante3, Alexandra Rucavado3, Jonas Perales1, Richard Valente1 Ana Gisele Neves-Ferreira1 1 Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Rio de Janeiro, Brazil 2 Instituto Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil 3 Instituto Clodomiro Picado, San José, Costa Rica
P-499 NEW WEAPONS AGAINST PERVASIVE FISH FRAUD: TOP DOWN PROTEOMICS AND A NEW HIGH THROUGHPUT LC-MS PLATFORM Daniel Lopez-Ferrer1, Michael Blank1, Monica Carrera2, Jose Manuel Gallardo2, Michael Andersen3, Nikolai Bache3, Andreas Huhmer1 1 Thermo Fisher Scientific, San Jose CA, USA 2 Instituto de Investigaciones Marinas, Vigo, Spain 3 Thermo Fisher Scientific, Germering, Germany
188 P-500 EVALUATION OF PROTEOLYTIC EXCISION ONLINE SAW-BIOSENSOR-MASS SPECTROMETRY TO MAP CONTACT SURFACES: APPLICATION TO VEGF-AVASTIN SYSTEM Mireia Diaz-Lobo1, Mar Vilanova1, Marina Gay1, Adrian Moise2, Stefan Slamnoiu2, Michael Przybylski2, Marta Vilaseca1, 1 Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain 2 University of Konstanz, Konstanz, Germany
P-501 CLINICAL SCREENING OF HEMOGLOBINOPATHIES USING TOP DOWN MASS SPECTROMETRY Julia Smith1, James Scrivens2, Sarah Nicolle4, Jane Newbold4, Krisztina Radi3 1 Bruker UK, Coventry, UK 2 Univ of Warwick, Coventry, UNITED KINGDOM 3 University of Warwick - Life Sciences, Coventry, UNITED KINGDOM 4 Coventry and Warwickshire Hospital, Coventry, UK
189 12 - Integrative proteomics and systems biology
P-502 A SYSTEMS BIOLOGY APPROACH UNRAVELS THE ROLE OF MIR-17-92 IN FINE-TUNING MYC-CENTERED REGULATORY NETWORKS TO SUSTAIN CANCER PROGRESSION Tiziana Bonaldi1, Marjia Mihailovic1, Michael Bremang1, Elena Vitale1, Gabriele Varano2, Francesco Mancuso1,3, Federico Zambelli4, Giulio Pavesi4 Stefano Casola2 1 European Oncologic Institute, Milan- Italy 2 IFOM, FIRC Institute of Molecular Oncology Foundation, Milan ITALY 3 Centre for Genomic Regulation and Universitat Pompeu Fabra, Barcelona- SPAIN 4 Milan University, Milan -ITALY
P-503 PROTEOMIC AND TRANSCRIPTOMIC ANALYSIS OF LIQUID NON-SPORULATING STREPTOMYCES COELICOLOR CULTURES DEMONSTRATES THE EXISTENCE OF A COMPLEX DIFFERENTIATION COMPARABLE TO THAT OCCURRING IN SOLID SPORULATING CULTURES Paula Yagüe1, Antonio Rodriguez-Garcia2, Maria Teresa López-García1, Beatriz Rioseras1, Ole Jensen3, Angel Manteca1 1 Universidad De Oviedo 2 Instituto de Biotecnología de León, INBIOTEC 3 University of Southern Denmark
P-504 QUANTITATIVE PROTEOMIC ANALYSIS OF RAT MESENCHYMAL STEM CELLS AT DIFFERENT AGES Juan Fafián1, Jesús Mateos2, Pablo Fernández1, Susana Sangiao1, Isaac Fuentes1, Javier De Toro1, Francisco Blanco2 María Arufe1 1 University of A Coruña 2 INIBIC
P-505 COMPREHENSIVE CHARACTERIZATION OF A LIVER TISSUE AND HEPG2 CELLS TRANSCTIPROPROTEOME FOR HUMAN CHROMOSOME 18 Ekaterina Poverennaya1 Institute Of Biomedical Chemistry RAMS
P-506 DIGESTOMICS OF HUMAN MILK DURING LACTATION AND MASTITIS Andres Guerrero Navarro1, Stephanie Contreras1, Dave Dallas1, Jincui Huang1, Elisha Goonatilleke1, Evan Parker1, Xin Sun1, Daniela Barile1 Bruce German1 Carlito Lebrilla1 University Of California, Davis
190 P-507 THE HUMAN KIDNEY SPECIFIC PROTEOME DEFINED BY TRANSCRIPTOMICS AND ANTIBODY-BASED PROFILING Masato Habuka1, Linn Fagerberg1, Björn Hallström1, Caroline Kampf2, Tadashi Yamamoto3, Fredrik Pontén2, Mathias Uhlén1, Jacob Odeberg1 1 Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden 2 Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Sweden 3 Department of Structural Pathology, Institute of Nephrology, Medical and Dental School, Niigata 4Univer- sity, Niigata, Japan
P-508 IDENTIFICATION OF ENRICHED PTM CROSSTALK MOTIFS FROM LARGE-SCALE EXPERIMENTAL DATASETS Mao Peng1, Arjen Scholten1, Albert J.R. Heck1, Bas van Breukelen1 Biomolecular Mass Spectrometry And Proteomics, Utrecht University
P-509 CONSERVED AND DIVERSE ASPECT OF PROTEOME PROFILE ACROSS MULTIPLE YEAST SPECIES Keiji Kito1, Haruka Ito1, Takehiro Nohara1, Mihoko Ohnishi1, Daisuke Takeda1 Meiji University
P-510 SANXOT: A NOVEL FUNCTIONAL CLASS-SCORING ALGORITHM FOR SYSTEMS BIOLOGY AND ANALYSIS OF COORDINATED PROTEIN BEHAVIOR Marco Trevisan-Herraz1, Elena Bonzon-Kulichenko1, Fernando Garcia-Marques1, Juan Antonio Lopez1, Emilio Camafeita1, Inmaculada Jorge1, Jesús Vázquez1, 1 Cnic
P-511 THE PROTEOMIC POINT OF VIEW ON HUMAN TEETH AND SALIVA SAMPLES Michal Jágr1, Adam Eckhardt1, Statis Pataridis1, Ivan Mikšík1 1 Institute Of Physiology, Academy Of Sciences Of The Czech Republic
P-512 ANALYSIS OF CHRONIC LUNG ALLOGRAFT DYSFUNCTION (CLAD) AFTER LUNG TRANSPLANTATION BY PROTEOMIC APPROACHES OF BRONCHOALVEOLAR LAVAGE AND PLASMA FLUIDS Sandrine Bourgoin-Voillard1,2,3, Candice Trocme1,3, Johanna Claustre1,2,3, Hélène Flamant-Waret1,2,3, Izabel Bérard1,2,3, Karine Botturi-Cavailles4, Antoine Magnan4, Laurent Nicod5 Christophe Pison1,3,6 Michel Seve1,2,3 1 Université Grenoble Alpes, Grenoble, France 2 INSERM/Institut Albert Bonniot, Grenoble, France 3 CHU Grenoble, Grenoble, France 4 CHU Nantes, Institut du Thorax, INSERM UMR 1087 / CNRS UMR 6291, Nantes, France 5 Centre HospitalP-Universitaire Vaudois, Lausanne, Suisse 6 European Institute of Systems Biology and Medicine, Lyon, France
191 P-514 AN EXTENSIVE PROTEOME PROFILING OF VISCERAL ADIPOSE TISSUES FOR UNDERSTANDING THE RELATION WITH EARLY PATHOGENESIS OF TYPE 2 DIABETES MELLITUS Dong-Gi Mun1, Seunghoon Back1, Hokeun Kim1, Sang-Won Lee Korea University
P-515 INVESTIGATION OF DRUG-INDUCED STEATOSIS IN HEPARG CELLS AFTER LONG-TERM TREATMENT WITH VALPROIC ACID USING LC/MS-BASED QUANTITATIVE PROTEOMICS Georg Tascher1, Marine Plumel1, Sebastian Klein2, Elmar Heinzle2, Fozia Noor2, Alain Van Dorsselaer1, Fabrice Bertile1, 1 Institut Pluridisciplinaire Hubert Curien (CNRS UMR7178), Strasbourg; France 2 Saarland University, Saarbrücken; Germany
P-516 DYNAMIC ASSESSMENT OF FIN REGENERATION IN ZEBRAFISH USING A PULSED SILAC APPROACH Hendrik Nolte1, Soraya Hölper1, Anne Konzer1, Michael Housley1, Thomas Braun1, Marcus Krüger1 Max Planck Institute Bad Nauheim
P-517 AN ENHANCED INDUSTRIAL-RELEVANT PRODUCTS PORTFOLIO FOR CORYNEBACTERIUM GLUTAMICUM BY MEANS OF PROTEOMIC APPROACHES. Carlos Barreiro1, María F Vasco-Cárdenas1, Fernando Pérez-García1, Eva Rubio-Sabugo1, Rosario Pérez-Redondo1, Ricardo V Ullán1, Juan F Martín6, 1 INBIOTEC (Instituto de Biotecnología de León), Parque Científico de León, Avda. Real 1, 24006 León, Spain 2 Área de Microbiología, Departamento de Biología Molecular, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain
P-518 PROTEOMIC ANALYSIS OF THE ENZYMATIC EXTRACT OF THE FERULOYL ESTERASE PRODUCER PENICILLIUM CHRYSOGENUM B13 Carlos Barreiro1, Raquel Rodríguez-Castro1, Silvia M Albillos1, Marta Fernández-Aguado1, Laura García-Calvo1, Ricardo V Ullán1 1 INBIOTEC (Instituto de Biotecnología de León), Parque Científico de León, Avda. Real 1, 24006 León, Spain
192 P-519 PROTEOMIC ANALYSIS OF A MUTANT OF TRICHODERMA ARUNDINACEUM IMPAIRED IN TRICHOTHECENE BIOSYNTHESIS REVEALS A SYSTEMIC FUNCTION OF THESE COMPOUNDS IN FUNGAL PHYSIOLOGY Carlos Barreiro5, Mónica G Malmierca1, Rosa E Cardoza2, Susan P McCormick3, Nancy J Alexander4, Enrique Monte6, Santiago Gutiérrez7, 1 Area of Microbiology. Universitary School of Agricultural Engineers. University of León. Campus de Ponferrada. Avda. Astorga s/n. 24400 Ponferrada, Spain. 2 Area of Microbiology. Universitary School of Agricultural Engineers. University of León. Campus de Ponferrada. Avda. Astorga s/n. 24400 Ponferrada, Spain. 3 Bacterial Foodborne Pathogen and Mycology Unit, USDA/ARS, National Center for Agricultural Utilization Research, Peoria Illinois 61604-3902. USA 4 Bacterial Foodborne Pathogen and Mycology Unit, USDA/ARS, National Center for Agricultural Utilization Research, Peoria Illinois 61604-3902. USA 5 INBIOTEC (Instituto de Biotecnología de León), Parque Científico de León, Avda. Real 1, 24006 León, Spain 6 Spanish-Portuguese Centre of Agricultural Research (CIALE), Department of Microbiology and Genetics, University of Salamanca, Edificio Departamental lab 208, Plaza Doctores de la Reina s/n, 37007 Salamanca, Spain 7 Area of Microbiology. Universitary School of Agricultural Engineers. University of León. Campus de Ponferrada. Avda. Astorga s/n. 24400 Ponferrada, Spain.
P-520 SERUM PROTEOMICS IN MELANOMA BIOMARKER DISCOVERY María Dolores Boyano1, Idoia Ortega-Martínez 1, Jesús Gardeazabal2, Asier Erramuzpe3, Rocio Fernandez-Suarez1, Erika Alonso-Tejerina1, Gorka Pérez-Yarza1, Ildefonso de la Fuente5 Cortes Jesus M3,4 Aintzane Asumendi1 1 Department of Cell Biology and Histology, University of the Basque Country (UPV/EHU), E-48940 Leioa, SPAIN. 2 Department of Dermatology, Ophathalmology and Otorhinolaryngology, University of the Basque Country (UPV/EHU), E-48940 Leioa, SPAIN. 3 Quantitative Biomedicine Unit. BioCruces Health Research Institute, Cruces University Hospital. Ikerbasque, The Basque Foundation for Science, Bilbao, Spain. 4 Instituto de Parasitología y Biomedicina “López-Neyra” (CSIC), Granada, Spain.
P-521 AN INTEGRATED PROTEOMICS AND METABOLOMICS APPROACH FOR MOLECULAR CHARACTERIZATION OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA Nazia Syed1,2, Mustafa Barbhuiya3, Keshava Datta1,4, Sartaj Ahmad1,5, Rekha Kumar6, TS Keshava Prasad1, Gundimeda Ramanjaneyulu1, Aditi Chatterjee1 Akhilesh Pandey1,3 Harsha Gowda1 1 Institute of Bioinformatics, International Technology Park, Bangalore 560066, India 2 Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry 605014, India 3 Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 4 School of Biotechnology, KIIT University, Bhubaneswar 751024, India 5 Manipal University, Madhav Nagar, Manipal, Karnataka 576104, India 6 Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India
193 P-522 UTILIZING A QUANTITATIVE PROTEOMIC APPROACH TO DISCOVER NOVEL SUBSTRATES OF PROPROTEIN CONVERTASE 7 Deeptee Seebun1,2, Rui Chen1,2, Daniel Figeys1,2 1 Ottawa Institute Of Systems Biology 2 University Of Ottawa
P-523 PROTEOMICS AND BIOMARKERS IN OSTEOARTHRITIS Bryan Krastins1, Mary Lopez1, David Sarracino1, Susan Ritter2, Antonious Aliprantis2, Gregory Byram1, Maryann Vogelsang1, Scott Peterman1 Gouri Vadali 1 Thermo Fisher Scientific, Cambridge, MA USA 2 Brigham and Women’s Hospital, Boston, MA USA
P-524 ITRAQ-BASED PROTEOME PROFILING OF THREE HUMAN LIVER-DERIVED CELL LINES: COMPARISON WITH PRIMARY HEPATOCTYES AS MODELS FOR DRUG SAFETY ASSESSMENT Neil Kitteringham1, Dimitra Mitsa1, Rosalind Jenkins1, Rowena Sison-Young1, Christopher Goldring1, Kevin Park1 1 MRC Centre For Drug Safty Science 2 Institute of Translational Medicine 3 University of Liverpool 4 Liverpool 5 Merseyside 6 L69 3GE UK
P-525 THE METACASPASE MCA1P HAS A DUAL ROLE IN FARNESOL-INDUCED APOPTOSIS IN CANDIDA ALBICANS Thibaut Léger1, Camille Garcia1, Marwa Ounissi1, Jean-Michel Camadro1 1 Mass spectrometry Laboratory, Institut Jacques Monod, UMR 7592, Univ Paris Diderot, CNRS, 2Sorbonne Paris Cité, F-75205 Paris, France
P-526 A SENTINEL PROTEIN ASSAY FOR THE QUANTIFICATION OF CELLULAR PROCESS ACTIVITIES USING PRM AND DIA Paul Boersema1, Martin Soste1, Yue Xuan2, Rita Hrabakova3, Paola Picotti1 1 Institute Of Biochemistry, ETH Zürich 2 Thermo Fisher Scientific, Bremen, Germany 3 Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic
P-527 ABSOLUTE QUANTIFICATION OF PROTEINS AND PROTEIN MODIFICATIONS ON THE SINGLE-CELL LEVEL BY COMBINING MASS CYTOMETRY AND TARGETED PROTEOMICS Serena Di Palma1, Paul Boersema2, Paola Picotti2, Bernd Bodenmiller1 1 University Of Zurich 2 ETH, Zurich
194 P-528 SWATH-MS FOR QUANTITATIVE PROTEOMICS OF NUCLEIC ACID BINDING AND REGULATORY PROTEINS Nicole Haverland1, Howard Fox1, Pawel Ciborowski1 1 University Of Nebraska Medical Center
P-529 WEAK LINEAR MOTIF-MEDIATED INTERACTIONS CONTRIBUTE TO THE REARRANGEMENT OF MODULAR ARCHITECTURE IN COMPLEX PROTEIN INTERACTION NETWORKS Inhae Kim1, Hee-tak Lee1, Seong Kyu Han1, Sanguk Kim1 1 Pohang University Of Science And Technology
P-530 INTEGRATIVE MAPPING OF THE ZEBRAFISH EMBRYO PROTEOME AND TRANSCRIPTOME Jayantha Gunaratne1, Asfa Alli Shaik1, Sheena Wee1, Rachel H Li1, Zhen Li2, Tom J. Carney1, Sinnakaruppan Mathavan2, 1 Institute Of Molecular & Cell Biology 2 Genome Institute of Singapore
P-531 GENE ESSENTIALITY ON MODEL ORGANISM EXPLAINS CLINICAL SEVERITY OF HUMAN GENETIC DISORDERS Seong Kyu Han1, Inhae Kim1, Sanguk Kim1 Pohang University Of Science and Technology
P-532 USING AN ITRAQ APPROACH TO INVESTIGATE THE EFFECT OF CIGARETTE SMOKE EXPOSURE IN A 90-DAYS INHALATION STUDY FOLLOWED BY 42-DAYS RECOVERY PERIOD ON SPRAGUE-DAWLEY RATS LUNG TISSUE. Ashraf Elamin1, Thomas Schneider1, Sophie Dijon1, Bjoern Titz1, Florian Martin1, Ulrike Kogel1, Patrick Vanscheeuwijck1, Nikolai V. Ivanov1 Julia Hoeng1 Manuel C. Peitsch1 1Philip Morris International
P-533 DYNAMICS PERSONAL OMICS PROFILES DURING PERIODS OF HEALTH, DISEASE, WEIGHT GAIN AND LOSS Michael Snyder1, Wenyu Zhou1, Brian Piening1, Kimberly Kukurba1, Colleen Craig2, Rui Chen1, George Mias1, Jennifer Li-Pook-Than1 Hua Tang1 Tracey McLaughlin2 1 Department of Genetics, Stanford University School of Medicine 2 Department of Medicine, Stanford University
195 P-534 THE GLOBAL LANDSCAPE OF HEMATOPOIETIC STEM CELLS AND THEIR IMMEDIATE PROGENY Daniel Klimmeck1,2,3, Nina Cabezas-Wallscheid1,3, Jenny Hansson2, Daniel B. Lipka1, Alejandro Reyes2, Wolfgang Huber2, Michael D. Milsom1,3, Christoph Plass1 Jeroen Krijgsveld2 Andreas Trumpp1,3 1 Deutsches Krebsforschungszentrum (DKFZ) 2 European Molecular Biology Laboratory (EMBL) 3 Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH)
P-535 COMMUNITY PROTEOMIC ANALYSIS OF ARCHAEAL COMMUNITY OF CELLULOSE-ENRICHED MUD AND WATER SLURRY FROM MT. MAKILING MUD SPRING, LOS BAÑOS, PHILIPPINES Andrew Montecillo1, Asuncion Raymundo1, Nacita Lantican1, Ajay Kohli2, Jaime Samaniego3, Leopold Ilag4 1 Institute Of Biological Sciences, University Of The Philippines Los Baños, Los Baños, Laguna, Philippines 2 Plant Molecular Biology Laboratory, International Rice Research Institute, Los Baños, Laguna 3 Institute of Computer Science, University Of The Philippines Los Baños, Los Baños, Laguna, Philippines 4 Department of Analytical Chemistry, Stockholm University, Stockholm, Sweden
P-536 STRUCTURE-BASED PREDICTION AND BIOINFORMATICS ANALYSIS OF THE THIAMIN-DEPENDENT PROTEOME: IMPLICATIONS FOR THE THIAMIN DEFICIENCY STATES AND MODELS. V. Bunik1,2, V. Aleshin1, G. Mkrtchyan1, A. Artyukhov1 1 Faculty of Bioengineering and Bioinformatics of Lomonosov Moscow State University, Vorob’evy Gory 1, 119992 Moscow, Russian Federation 2 Belozersky Institute of Physicochemical Biology of Lomonosov Moscow State University, Vorob’evy Gory 1, 119992 Moscow, Russian Federation
P-537 TARGET IDENTIFICATION OF NON-TAGGED SMALL MOLECULES WITH DARTS AND LC/ MS/MS Yoon Sun Cho1, Hui-Yun Hwang1, Jin Young Kim2, Jong Shin Yoo2, Ho Jeong Kwon1 1 Chemical Genomics National Research Laboratory, Department of Biotechnology, Translational Research Center For Protein Function Control,College of Life Science & Biotechnology, Yonsei University,Seoul 120- 749, Korea, 2 Korea Basic Science Institute, Cheongwon-Gun, Chungbuk 363-883, Korea
P-538 PROTEOMIC COMPARATIVE STUDY OF SMOOTH MUSCULE CELLS ISOLATED FROM SMALL PULMONARY AND SYSTEMIC ARTERIES Marie Zaloudíková1, Adam Eckhardt2, Richard Vytásek1, Karel Karmazín1, Katerina Dousová1 1 Department of Pathophysiology, 2nd Faculty of Medicine, Charles University In Prague, Prague, Czech Republic 2 Institute of Physiology, Academy of Sciences of The Czech Republic, Víde?ská 1083, Prague 4
196 P-539 IDENTIFICATION OF SMALL OPEN READING FRAMES WITH HIGH CODING POTENTIAL IN MOSS PHYSCOMITRELLA PATENS G.P Arapidi1,2, I.A Fesenko1, K.A Babalyan1,2, A.V Seredina1, R.A Chazigaleeva1, E.S Kostrukova2, S.I Kovalchuk1,2, N.A Anikanov1 V.M Govorun1,2 V.T Ivanov1 1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS 2 Moscow Institute of Physics and Technology (State University)
P-540 ADVANCED TI4+-IMAC (PHOSPHO)PROTEOMICS TO IDENTIFY NOVEL MELANOMA COMPANION DRUG TARGETS AND UNCOVER PHOSPHORYLATION DYNAMICS AND PATHWAY DEPENDENCE IN SENESCENCE SIGNALING Erik L De Graaf1, Gianluca Maddalo1, Joanna Kaplon1, Marjon A. Smit,1, Daniel S. Peeper1, J.R. Heck1, A.F. Maarten Altelaar1, 1 Utrecht University, Utrecht, The Netherlands
197 13 - Inflammatory and rheumatic diseases
P-541 DISCOVERY OF SERUM BIOMARKERS FOR PREDICTION OF RESPONSE TO ADALIMUMAB IN RHEUMATOID ARTHRITIS TREATMENT Ignacio Ortea1, Bernd Roschitzki2, Juan Gabriel Ovalles3, Javier López3, Inmaculada de la Torre3, Isidoro González-Álvaro4, Juan José Gómez-Reino1, 5, Antonio González1 1 Rheumatology Unit, Instituto De Investigación Sanitaria, Hospital Clínico Universitario De Santiago De Compostela 2 Functional Genomics Center Zurich, University and ETH Zurich, Switzerland 3 Rheumatology Unit, Hospital Gregorio Marañón, Madrid, Spain 4 Rheumatology Unit, Hospital de la Princesa, Madrid, Spain 5 Department of Medicine, University of Santiago de Compostela, Spain
P-542 DIFFERENTIALLY EXPRESSED PROTEINS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS Hwa Chia Chai1,2, Kek Heng Chua1, Iekhsan Othman2, Maude Elvira Phipps2 1 University Of Malaya 2 Monash University (Malaysia Campus)
P-543 PROTEOMIC ANALYSIS OF THE MESENCHYMAL STEM CELLS SECRETOME USING A LABEL-FREE APPROACH Gabriella Tedeschi1, Elisa Maffioli1, Lucia Zanotti2, Armando Negri1, Simona Nonnis1, Cristina Ploia2, Viola Antonella2 1 University Of Milano 2 Humanitas Clinical and Research Center, Rozzano, Italy
P-544 POTENTIAL PROTEOMIC BIOMARKERS ASSOCIATED TO MUCOSAL HEALING IN CROHN’S DISEASE Marie-Alice Meuwis1, Gabriel Mazzucchelli2, Nicolas Smarggiasso2, Dominique Baiwir3, Florence Queseda-Calvo1, Michel Malaise4, Edwin De Pauw2, Edouard Louis1 1 Gastroenterology, GIGA-R,ULG, University Hospital Of Liège 2 Laoratory of mass spectrometry, dep of chemistry, GIGA-R, university of Liège 3 Proteomics facility GIGA University of Liège 4 Rheumatology, GIGA-R, ULg, University Hospital Of Liège
P-545 PROTEOMIC ANALYSIS OF CLUBFEET Adam Eckhardt1, Martin Oš ádal2,3, Jan Herget2, Bohumil Oš ádal1, Ivan Mikšík1 1 Institute Of Physiology, The Academy Of Sciences Of The Czech Republic 2 Department of Physiology, the 2nd Medical Faculty of Charles University, Prague, Czech Republic 3 Department of Orthopaedics, the 1st Medical Faculty of Charles University and Hospital Na Bulovce Prague, Czech Republic
198 P-546 MOLECULAR PROFILING OF PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) FOR THE IDENTIFICATION OF CELLULAR RESPONSES TO DEXAMETHASONE Andrea Bileck, Dominique Kreutz, Besnik Muqaku, Rupert Mayer, Astrid Slany, Christopher Gerner University Of Vienna - Institute Of Analytical Chemistry
P-547 PROTEOMIC ANALYSIS USING NUCLEID ACID PROGRAMMABLE PROTEIN ARRAYS FOR SERUM AUTOANTIBODY PROFILING IN RHEUMATIC DISEASES Lucía María Lourido Salas1, Juan Fernandez-Tajes1, Valentina Calamia1, Carolina Fernández1, Beatriz Rocha1, Patricia Fernández-Puente1, Jesús Mateos1, Manuel Fuentes2 Francisco J.Blanco1 Cristina Ruiz-Romero1 1 Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, 15006 A Coruña-SPAIN. 2 Centro de Investigación del Cáncer/IBMCC (USAL/CIC), IBSAL, Departamento de Medicina, Unidad de Proteomica Servicio general de Citometría, Universidad de Salamanca, Salamanca, SPAIN.
P-548 PROFILING OF CARTILAGE-CHARACTERISTIC PROTEINS TO IDENTIFY A NOVEL PANEL OF OSTEOARTHRITIS BIOMARKER CANDIDATES. Lucía María Lourido Salas, Valentina Calamia, Patricia Fernández-Puente, Jesús Mateos, Carolina Fernández-Costa, Francisco J. Blanco, Cristina Ruiz-Romero Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, 15006 A Coruña-Spain.
P-549 SILAC-BASED PROTEOMIC ANALYSIS REVEALED DIFFERENTIALLY EXTRACELLULAR PROTEIN PROFILES OF OSTEOARTHRITIC AND NORMAL MESENCHYMAL STEM CELLS UNDERGOING CHONDROGENESIS. Beatriz Rocha1, Valentina Calamia1, Vanessa Casas2, Lucía Lourido1, Carolina Fernández-Costa1, Patricia Fernández-Puente1, Jesús Mateos1, Montserrat Carrascal2 Cristina Ruiz-Romero1,3 Francisco J. Blanco1 1 Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña 2 Laboratorio de Proteómica CSIC/UAB, Barcelona, SPAIN 3 CIBER-BBN, INIBIC-CHUAC, A Coruña, SPAIN
P-550 SERUM PEPTIDE PROFILES OF OSTEOARTHRITIS AND RHEUMATIC DISORDERS BY MALDI-TOF MASS SPECTROMETRY Carolina Fernandez-Costa1, Lucia Lourido1, Beatriz Rocha1, Valentina Calamia1, Patricia Fernandez-Puente1, Jesús Mateos1, Jose Luis Capelo-Martinez2, Cristina Ruiz-Romero1,3 Francisco J. Blanco1 1 INIBIC-Hospital Universitario A Coruña, SPAIN 2 Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa, Caparica, Portugal 3 CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain
199 P-551 CHARACTERIZATIONS OF HEPARIN-BINDING PROTEINS IN HUMAN URINE AND IDENTIFICATION OF “L-X(2,3)-A-X(0,1)-L” AS A NOVEL HEPARIN-BINDING MOTIF. Juthatip Manissorn, Visith Thongboonkerd Siriraj Hospital, Mahidol University
P-552 PROTEOMICS REVEALED AN IMPORTANT ROLE OF LAMIN A/C IN KIDNEY STONE DISEASE. Nutkridta Pongsakul, Visith Thongboonkerd Siriraj Hospital, Mahidol University
P-553 DYNAMIC PROFILING OF CHROMATIN PROTEOME AT ENHANCERS OF INFLAMMATORY GENES Monica Soldi, Gianluca Sigismondo, Tiziana Bonaldi European Institute Of Oncology (IEO), Mialn, Italy
P-554 QUANTITATIVE PROTEOMICS (ITRAQ) REVEALS PUTATIVE BIOMARKERS IN PRE-RADIOLOGICAL OSTEOARTHRITIS Jesús Mateos1, Alejandra Pintor-Iglesias1, Patricia Fernández-Puente1, Sara Relaño1, Ignacio Rego1, Natividad Oreiro1, Carlos López-Fernández1, Cristina Ruiz-Romero1,2 Francisco J Blanco1,2,3 1 Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, 15006 A Coruña-SPAIN 2 CIBER-BBN-Spain 3 Department of Medicine. University of Santiago de Compostela. Spain.
P-555 SECRETED PEPTIDOME OF HUMAN CARTILAGE: A NOVEL SOURCE FOR EARLY OA BIOMARKER DISCOVERY Valentina Calamia1, Lucía Lourido1, Jesús Mateos1, Patricia Fernández-Puente1, Carolina Fernández-Costa1, Beatriz Rocha1, Carlos García2, Anabel Marina2 Francisco Blanco1 Cristina Ruiz-Romero1 1 Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, 15006 A Coruña-Spain. 2 Laboratorio de Proteómica, Centro de Biología Molecular Severo Ochoa, Madrid, Spain.
P-556 EVALUATION OF ADHERENCE TO “GLOBAL INITIATIVE FOR CHRONIC OBSTRUCTIVE LUNG DISEASE” GUIDELINES FOR MANAGEMENT OF COPD EXACERBATION IN FAGHIHI HOSPITAL, SHIRAZ, IRAN 2012-13 Abbas Mohammadi1, Somayeh Mohammadi2, Pooria Ghadiri1, Alireza Setarehaseman1, Nazila Hasanabadi1 1 Students research center, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Department of Anesthesiology, Resident of Anesthesiology, Kermanshah university of Medical Sciences, Kermanshah, Iran.
200 P-557 CHARACTERIZATION OF THE HOST AND MICROBIOTA PROTEOME IN PEDIATRIC IBD Shelley Deeke1, Amanda Starr1, Alain Stinzi1, David Mack2, Daniel Figeys1 1 University Of Ottawa 2 Children’s Hospital of Eastern Ontario
P-558 ITRAQ APPROACH TO INVESTIGATE THE IMPACT OF CIGARETTE SMOKE, SMOKING CESSATION AND SWITCHING TO A PROTOTYPIC MODIFIED RISK TOBACCO PRODUCT ON THE LUNG PROTEOME OF C57BL/6 MICE Thomas Schneider1, Sophie Dijon1, Ashraf Elamin1, Blaine Phillips2, Emilija Veljkovic1, Bjoern Titz1, Florian Martin1, Nikolai Ivanov1 Julia Hoeng1 Manuel Peitsch1 1 Philip Morris International, Research & Development, Neuchatel, Switzerland 2 Philip Morris International, Research & Development, Singapore, Singapore
P-559 THE EFFECT OF HMGB1 A BOX ON ACUTE LUNG INJURY Manbok Choi, Ji Hyun Song, Minhyung Lee Hanyang University
P-560 MOLECULAR PORTRAITS OF SYSTEMIC LUPUS ERYTHEMATOSUS USING AFFINITY PROTEOMICS FOR IMPROVED DIAGNOSIS BASED ON A BLOOD TEST Payam Delfani1, Linda Dexlin Mellby1, Gunnar Sturfelt2, Carl A.K. Borrebaeck1,2, Anders A. Bengtsson2, Christer Wingren1 1 Dept. of Immunotechnology and CREATE Health, Lund University, Medicon Village, SE-221 83 Lund, Sweden. 2 Dept. of Clinical Sciences, Section of Rheumatology, Lund University Hospital, Lund University, SE-221 85 Lund, Sweden.
P-561 A MECHANISTIC STUDY USING 2D-PAGE PROTEOMIC APPROACH TO INVESTIGATE THE EFFECT OF CIGARETTE SMOKE-INDUCED COPD, CESSATION AND SWITCHING TO MODIFIED RISK TOBACCO PRODUCT IN THE LUNGS OF C57BL/6 MICE Sophie Dijon1, Thomas Schneider1, Ashraf Elamin1, Emilija Veljkovic1, Blaine Phillips2, Bjoern Titz1, Florian Martin1, Nikolai Ivanov1 Julia Hoeng1 Manuel Peitsch1 1 Philip Morris International Research & Development, Neuchâtel, Switzerland 2 Philip Morris International Research & Development, Singapore, Singapore
P-562 PROTEOMIC ANALYSIS OF ULCERATIVE COLITIS (UC): REDUCED MUCOSAL LEVEL OF INSOLUBLE KERATIN 8 PROTEOFORMS IN ACTIVE UC RELATIVE TO PROXIMAL UNIN- VOLVED COLONIC MUCOSA. Caroline Evans1, Arash Assadsangabi1, Joanne Connolly2, Debabrata Majumdar1, Phillip Wright1, Bernard Corfe1, Alan Lobo1 1 The University of Sheffield, Sheffield, South Yorkshire, UK 2 Waters, Wilmslow, Cheshire, UK
201 P-563 ON THE WAY TOWARD A THERAPEUTIC DECISION-MAKING TOOL FOR A BETTER MANAGEMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS A. Obry1, K. Roget2, G. Legent2, T. Lequerre3, J. Hardouin4, C. Heuclin2, O. Vittecoq3, P. Cosette4 1 U905 Inserm, PISSARO Proteomic Platform, University of Rouen, France 2 BioSIMS Company, Rouen, France 3 U905 INSERM, Department of Rheumatology, Rouen University Hospital, University of Rouen France 4 UMR6270 CNRS, PISSARO Proteomic Platform, University of Rouen, France
P-564 SHARED IMMUNOLOGICAL TARGETS IN THE LUNGS AND JOINTS OF PATIENTS WITH RHEUMATOID ARTHRITIS: IDENTIFICATION AND VALIDATION. A. Jimmy Ytterberg1,2, Vijay Joshua1, Gudrun Reynisdottir1, Nataliya K Tarasova2, Dorothea Rutishauser2, Elena Ossipova2, Aase Haj Hensvold2, Anders Eklund2 C. Magnus Sköld2 Johan Grunewald2 Vivianne Malmström2 Per-Johan Jakobsson, Johan Rönnelid, Leonid Padyukov, Roman A. Zubarev, Lars Klareskog, Anca I. Catrina 1 Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden 2 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden 3 Department of Immunology, Genetics and Pathology; Uppsala University, Uppsala, Sweden
202 14 - Glycomics in biology and diseases
P-565 NOVEL PROTOCOL FOR PREPARATION AND NLC-MS/MS CHARACTERIZATION OF PROTEOGLYCAN LINKAGE REGION GLYCOPEPTIDES OF HUMAN PLASMA, URINE AND CEREBROSPINAL FLUID SAMPLES Göran Larson1, Fredrik Noborn1, Alejandro Gomez Toledo1, Jonas Nilsson1 1 Institute of Biomedicine, The Sahlgrenska Academy at the University Of Gothenburg
P-566 EVALUATION OF SERUM CARBOHYDRATE-DEFICIENT TRANSFERRIN BY HPLC AND MALDI-TOF MS Kazuyuki Sogawa1,2, Fumie Iida2, Yusuke Kawshima3, Mako Yamada4, Mamoru Satoh2,4, Hirotaka Takizawa5, Katsuya Maruyama6, Yoshinao Wada7 Fumio Nomura2,4 1 Department Of Biochemistry, School Of Life And Environmental Science, Azabu University, Kanagawa, Japan 2 Clinical Proteomics Research Center, Chiba University Hospital, Chiba, Japan 3 Center for Disease Proteomics, School of Science, Kitasato University, Kanagawa, Japan 4 Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan 5 Kashiwado Memorial Foundation, Kashiwado Clinic in Port-Square, Chiba, Japan 6 National Hospital Organization Kurihama Alcoholism Center, Kanagawa, Japan 7 Department of Molecular Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan
P-567 A MULTIPLE REACTION MONITORING METHOD TO SPECIFICALLY CHARACTERIZE AND RELATIVELY QUANTIFY THE P-GLYCANS OF THE POTENTIAL BIOLOGIC LUBRICIN Sarah A. Flowers1, Catherine S. Lane2, Liaqat Ali1, Tannin Schmidt3, Niclas G. Karlsson1 1University of Gothenburg, Gothenburg, Sweden 2AB Sciex, Warrington, UK 3University of Calgary, Calgary, Alberta, Canada
P-569 USE OF HYDRAZINONICOTINIC ACID AS DERIVATIZATION REAGENT FOR ENHANCED DETECTION OF OLIGOSACCHARIDES BY MALDI-MS Jing Jiao1, Ying Zhang, Yan Cai, Pengyuan Yang, Haojie Lu, 1 Fudan University
P-570 N-GLYCOMIC AND N-GLYCOPROTEOMIC ANALYSIS OF THREE SNAKE VENOMS Jiangming Huang1, Weiqian Cao1, Pengyuan Yang1 Fudan University
P-571 CAPILLARY ELECTROPHORESIS FOR MONITORING GLYCOPROTEIN CHANGES ASSOCIATED TO VASCULAR DISEASES AND PROSTATE CANCER Angel Puerta1, Noemi Farina-Gomez1, Monica Gonzalez1, Raul Garrido-Medina1, Olga Regueiro-Vilar1, Gabriel Morales-Cid1, Jose C. Diez-Masa1, Mercedes de Frutos1 1 Institute Of Organic Chemistry. CSIC
203 P-572 PREPARATION OF A NOVEL SENSITIVITY LECTIN SUSPENSION MICROARRAY SYSTEM AND APPLICATIONS TO SERUM PEPTIDOME GLYCAN PROFILING Wei Liming1, Li Hong1, Shen Huali1, Lu Haojie1, Yang Pengyuan1 1 Department Of Chemistry & Institutes Of Biomedical Sciences
P-573 N-LINKED GLYCOPROTEOMIC ANALYSIS OF ESOPHAGEAL CELLS STIMULATED BY PRP-INFLAMMATORY CYTOKINES Hua Xiao1, David E. Misek2 1 Shanghai Jiao Tong University,Shanghai, 200240, China 2 University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA
P-574 GLYCOPATTERNS OF HUMAN SALIVARY GLYCOPROTEINS AND THEIR ROLES AGAINST INFLUENZA A VIRUS Zheng Li1, Yaogang Zhong1, Tianran Ma1, Yannan Qin1, Peixin Zhang1, Hanjie Yu1, Minzhi Zhu1, Liuyi Dang1 Ganglong Yang1 Xiurong Wang2 1 Laboratory for Functional Glycomics, College of Life Sciences, Northwest University 2 National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute
P-575 CARBOHYDRATES MODIFICATIONS IN GRASS POLLEN GROUP 13 ALLERGENS Chiara Giangrande1, Pascal Poncet2,3, Hélène Sénéchal2, Jean-Pierre Sutra2, Joelle Vinh1 1 Spectrométrie De Masse Biologique et Protéomique, ESPCI-ParisTech, PSL Research University, Paris, France. CNRS USR 3149, Paris France 2 Laboratoire de Biochimie et Biologie Moléculaire, Equipe Allergie & Environnement , Hôpital Armand Trousseau, Paris France 3 Département Infections et Epidémiologie, Institut Pasteur, Paris, France
P-576 GLYCAN CHANGES OF PLASMA TRANSFERRIN IN ELASTASE-INDUCED EMPHYSEMA AND LPS-INDUCED ACUTE LUNG INJURY MICE MODELS Miyako Nakano1, Katsunori Shirai1, Reiko Fujinawa2, Satoshi Kobayashi2, Shinobu Kitazume2, Naoyuki Taniguchi2 1 Hiroshima University, Hiroshima, Japan 2 RIKEN Global Research Cluster, RIKEN-Max Planck Joint Research Center, Saitama, Japan
P-577 GRIP-GUI: GRAPHIC USER INTERFACE FOR GLYCOPEPTIDE REVEAL & INTERPRETATION PLATFORM. Zhang Yang1 1 Fudan University
P-578 THE SEPARATION AND IDENTIFICATION OF GLYCANS USING AN ULTRA HIGH RESOLUTION COLUMN AND AN ULTRA HIGH RESOLUTION MASS SPECTROMETER Julian Saba1, Udayanath Aich2, Rosa Viner1, Xiaodong Liu2, Srinivasa Rao2, Jeff Rohrer2, Chris Pohl2, 1 Thermo Fisher Scientific, San Jose, CA 2 Thermo Fisher Scientific, Sunnyvale, CA
204 P-579 PROTEOMIC ANALYSIS OF THE EFFECTS OF ALOE VERA IN KIDNEY OF STREPTOZOTOCIN-INDUCED DIABETIC RATS Lilian Santos1, Lilian Arita1, Kleiton Silva1, Mirtes Tanae1, Juliana Perez1, Tatiana Cunha1, 2, Maria Teresa Lima-Landman1, Danielle Arita1 Valdemir M. Carvalho3 Dulce Casarini1 1 Federal University of Sao Paulo, Sao Paulo, Sao Paulo/Brazil 3 Federal University of Sao Paulo, Sao Jose dos Campos, Sao Paulo/Brazil 4 Fleury Group, Sao Paulo, SP, Brazil
P-580 GLYCOFOREST - DISTILLING GLYCOMIC MS/MS DATA Oliver Horlacher1,2, Catherine A. Hayes3, Davide Alocci1,2, Frederic Nikitin1, Markus Muller1,2, Niclas G. Karlsson3, Frederique Lisacek1,2 1 Swiss Institute Of Bioinformatics 2 University of Geneva 3 Gothenburg University, Sweden
P-581 SITE SPECIFIC GLYCOSYLATION OF SERUM PROTEINS IN CANCER DISEASES – FROM DISCOVERY TO QUANTIFICATION Michaela Scigelova1, Petr Pompach2, Gary Woffendin1, Jaroslav Pol1, Petra Darebna3, Ondrej Topolcan4, Petr Novak2 1 Thermo Fisher Scientific 2 Institute of Microbiology Czech Academy of Sciences 3 Faculty of Sciences Charles University Prague 4 Faculty Hospital Pilsen
P-582 N-GLYCOSYLATION ANALYSIS OF TRASTUZUMAB BIOSIMILAR CANDIDATES BY LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY STRATEGIES Carmen Duran1, Ivan Sanchez-De Melo2, Miguel Curto2, Paola Grassi3, Francisco Ochoa2, Anne Dell3, Francisco García-Cózar1 1 Cadiz University, Biomedicine, Biotechnology and Public Health Department. 2 Curaxys Biopharmaceuticals, cadiz, Spain 3 Biopolymer Mass Spectrometry group, Imperial College, London, UK
P-583 INFORMATICS SUPPORT FOR ISOMERIC SEPARATION AND THE STRUCTURAL IDENTIFICATION OF LABELED N-GLYCANS FROM PROTEINS Ningombam Sanjib Meitei1, Arun Apte2, Udayanath Aich3, Julian Saba4 1 PREMIER Biosoft, Indore, India 2 PREMIER Biosoft, Palo Alto, US 3 Thermo Fisher Scientific, Sunnyvale, CA 4 Thermo Fisher Scientific, San Jose, CA
P-584 IMPROVED GLYCOPEPTIDE ANALYSIS USING ACETONITRILE ENRICHED SHEATH GAS AND OXONIUM ION DEPENDENT ETD Andrea Schneider1, Kristina Marx1, Andrea Kiehne1, Markus Meyer1 1 Bruker Daltonik GmbH, Bremen, Germany
205 P-585 DEVELOPMENT AND APPLICATION OF A METHOD FOR THE GLYCOPEPTIDE-BASED SITE-SPECIFIC GLYCOMIC ANALYSIS Hiroyuki Kaji1, Azusa Tomioka1, Erika Noro1, Maki Sogabe1, Takashi Sato1, Toshihide Shikanai1, Hisashi Narimatsu1 1 National Institute Of Advanced Industrial Science And Technology (AIST)
P-586 HIGH-SENSITIVE DIFFERENTIAL GLYCAN PROFILING OF SERUM MUC1 TOWARD THE DEVELOPMENT OF A GLYCP-DIAGNOSTIC AGENT FOR CHOLANGIOCARCINOMA Atsushi Matsuda1, Atsushi Kuno1, Tomomi Nakagawa1, Yuzuru Ikehara1, Tatsuro Irimura2, Junichi Shoda3, Hisashi Narimatsu1 1 Glycomedicine Technology Research Center (GTRC), Advanced Industrial Science And Technology (AIST) 2 Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo 3 Graduate School of Comprehensive Human Sciences, University of Tsukuba
P-587 COMPREHENSIVE IDENTIFICATION OF GLYCOPROTEINS CARRYING LEWIS X AND SITE-SPECIFIC GLYCAN ALTERATION IN FUT9 KNOCKOUT MICE Erika Noro1,2, Akira Togayachi1, Takashi Sato1, Azusa Tomioka1, Mika Fujita1, Masako Sukegawa1, Nami Suzuki1, Hiroyuki Kaji1 Hisashi Narimatsu1,2 1 Glycomedicine Technology Research Center, National Institute Of Advanced Industrial Science And Technology (AIST) 2 Department of Biomolecular Function, Doctoral Program in Life System Medical Sciences, Graduate 3 School of Comprehensive Human Sciences, University of Tsukuba, Japan
P-588 ASSIGNMENT OF SACCHARIDE IDENTITIES THROUGH ANALYSIS OF OXONIUM ION FRAGMENTATION PATHWAYS IN LC-MS/MS OF GLYCOPEPTIDES Jonas Nilsson1, Adnan Halim2, Ulrika Westerlind3, Christian Pett3, Ulla Rüetschi1, Göran Larson1, 1 University Of Gothenburg/Inst. Of Biomedicine 2 University of Copenhagen/Copenhagen Center for Glycomics 3 Leibniz Institute for Analytical Science, Dortmund
P-589 A GLOBAL BOTTOM-UP STRATEGY FOR THE ANALYSIS OF GLYCOPROTEINS Estela Giménez1, Albert Barroso1, Fernando Benavente1, José Barbosa1, Victoria Sanz-Nebot1 1 Department of Analytical Chemistry, University of Barcelona, Diagonal 645, 08028 Barcelona, Spain.
P-590 CONSTRUCTION OF THE STANDARD METHOD FOR MOUSE TISSUE GLYCOME MAPPING IN HUPO BD-GPP INITIATIVE Atsushi Kuno1, Jun Iwaki1, Atsushi Matsuda1, Takashi Sato1, Maki Yoshida1, Yoko Itakura2, Masashi Toyoda2, Binbin Tan3 Sheng Ce Tao3 Yan Zhang3 Hiroyuki Kaji1 Hisashi Narimatsu 1 National Institute Of Advanced Industrial Science And Technology 2 Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan 3 Shanghai Jiao Tong University, Shanghai, China
206 P-591 GLYCOPROTEOMIC CHARACTERIZATION OF TRICHOMONAS VAGINALIS Andrea Carpentieri1, Gary G. Bushkin2, Catherine E Costello2, Angela Amoresano1, Phillip W. Robbins2, John C Samuelson2 1 Dipartimento Di Scienze Chimiche, Università Di Napoli “Federico II”, 2 Boston University, School of Medicine, Boston (MA)
207 15 - Proteomics of human microbiome and infectious diseases
P-592 LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY FOR COMPARING CLINICAL ISOLATES OF MRSA AND MSSA Shymaa Enany1, 2, Yutaka Yoshida1, Sameh Magdeldin1, Tadashi Yamamoto1 1 Niigata University 2 Suez Canal University
P-593 DISCOVERY AND VALIDATION OF BIOMARKERS TO GUIDE CLINICAL MANAGEMENT OF PNEUMONIA IN AFRICAN CHILDREN Climent Casals-Pascual1 1 University Of Oxford
P-594 APPLICATIONS OF PROTEOMIC METHODS IN SEVERE SEPSIS RESEARCH Susana Garcia-Obregon1, Javier Pilar-Orive1, Iratxe Seijas1, Mikel Azkargorta2, Felix Elortza2, Dolores Boyano3, Itziar Astigarraga2 1 BioCruces Health Research Institute, Hospital Universitario Cruces 2 CIC bioGUNE, Proteomics Platform, ProteoRed-ISCIII, CIBERehd 3 University of the Basque Country UPV/EHU
P-595 ANTIMICROBIAL ACTIVITIES OF SEVEN ESSENTIAL OILS FROM IRANIAN AROMATIC PLANTS AGAINST COMMON CAUSES OF ORAL INFECTIONS Pooria Ghadiri1, Kamiar Zomorodian2, Mohammad Jamal Saharkhiz3, Mohammad Reza Moein4, Peiman Mehriar5, Farideh Bahrani6, Tahereh Golzar7, Keyvan Pakshir8 Mohammad Mehdi Fani9 1 Student Research Committee, Faculty Of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran 2 Basic Sciences in Infectious Disease Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 3 Department of Horticultural Sciences, Faculty of Agriculture, Shiraz University, Shiraz, Iran 4 4Department of Pharmacognosy and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran 5 Department of Pharmacognosy and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran 6 Kamal Asgar Research Center (KARC), CA, USA 7 Department of Prosthodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. 8 Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 9 Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 10 Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
208 P-596 HYDATID CYST DISEASE OF THE SPINE: A CASE REPORT Nazila Hassanabadi1, Pooria Ghadiri1, Amirhossein Sharifian1, Abbas Mohammadi1, Alireza Nikseresht2, Hamid Reza Farrokhi3 1 Department of Neurology Student Research committee Shiraz university of Medical Sciences 2 Department of Neurology, Faculty of medicine, Shiraz university of Medical Sciences 3 Department of Neurosurgery, Faculty of medicine, Shiraz university of Medical Sciences
P-597 CEREBROSPINAL FLUID BIOMARKER CANDIDATES ASSOCIATED WITH HUMAN WNV NEUROINVASIVE DISEASE Christophe Fraisier1,2, Anna Papa3, Samuel Granjeaud4,5, Rogier Hintzen6, Byron Martina7, Luc Camoin4,5, Lionel Almeras1,2, 1 Aix-Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM 63, CNRS 7278, IRD 198, Inserm 1095, WHO Collaborative Center for Rickettsioses and 2Other Arthropod-borne Bacterial Diseases, Faculté de Médecine, 27 boulevard Jean Moulin, 13385 Marseille cedex 5, France 2 Institut de Recherche Biomédicale des Armées (Armed Forces Biomedical Research Institute, IRBA), antenne Marseille, Unité de Parasitologie, URMITE UM 63, GSBdD de Marseille Aubagne, 111 avenue de la Corse BP 40026, 13568 Marseille Cedex 02, France 3 Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece 4 Inserm, U1068, CNRS, UMR7258, CRCM, Aix-Marseille Univ, UM 105, Marseille, F-13009, France 5 Institut Paoli-Calmettes, Marseille Protéomique, Marseille, F-13009, France 6 Department of Neurology, Erasmus MC, 3000 CA Rotterdam, The Netherlands 7 Department of Virology, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
P-598 DEVELOPMENT OF A RAPID MICROBIAL PREPARATION SYSTEM FROM A BLOOD CULTURE BOTTLE USING CATIONIC PARTICLES FOR BACTERIAL IDENTIFICATION WITH MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY. Kaduho Ashizawa1, Koji Watanabe1, Yoko Teruuchi1, Masaru Bunya1, Motoi Nishimura2, Mamoru Satoh3, Sachio Tsuchida3, Syota Murata3 Fumio Nomura2 Kenta Noda1 1 Nittobo Medical Co., Ltd. 2 Chiba University 3 Chiba University Hospital
P-599 QUANTIFICATION OF BEXSERO® OMV PROTEINS BY A LABEL FREE LC MS/MS APPROACH Chiara Tani1, Maria Stella, Danilo Donnarumma, Massimiliano Biagini, Paolo Costantino, Fabio Rigat, Nathalie Norais, 1 Novartis Vaccines
209 P-600 IDENTIFICATION OF NATURALLY PROCESSED MHC CLASS I-RESTRICTED HIV EPITOPES PRESENTED BY HUMAN HIV-INFECTED CELLS Marijana Rucevic1, Georgio Kourjian1, Majahonkhe Shabangu2, Julie Boucau1, Carl Kadie3, Jonathan Carlson3, David Heckerman3, Bruce Walker1, 4 Sylvie LeGall1 1 Ragon Institute Of MGH, MIT And Harvard, Cambridge, MA 2 Harvard School of Engineering and Applied Sciences, Cambridge, MA 3 Microsoft Research, Los Angeles, CA 4 Howard Hughes Medical Institute, Chevy Chase, MD
P-601 WHY DATABASE MATTERS: IMPACT OF SEQUENCE DATABASES ON METAPROTEOME ANALYSIS OF A MOCK MICROBIAL MIXTURE Antonio Palomba1, Alessandro Tanca1, Massimo Deligios1,2, Tiziana Cubeddu1, Cristina Fraumene1, Grazia Biosa1, Daniela Pagnozzi1, Maria Filippa Addis1 Sergio Uzzau1,2 1Porto Conte Ricerche, Alghero, Italy 2Università di Sassari, Sassari, Italy
P-602 WHOLE PROTEOME AND MAIN POST-TRANSLATIONAL MODIFICATIONS (PTMS) ANALYSIS OF K. PNEUMONIAE CLINICAL ISOLATES Mariaconcetta Varano1, Marco Gaspari, Angela Quirino, Maria Carla Liberto, Giovanni Cuda, Alfredo Focà 1 University Magna Graecia Of Catanzaro, Italy
P-603 IDENTIFICATION OF API88 BINDING PARTNERS IN ESCHERICHIA COLI USING PHOTOAFFINITY-CROSSLINK STRATEGIES AND LABEL FREE QUANTIFICATION Daniela Volke1, Andor Krizsan1, Daniel Knappe1, Ralf Hoffmann1 1 Universität Leipzig, Institute of Bioanalytical Chemistry & Center for Biotechnology and Biomedicine
P-604 AFFINITY PROTEOMICS REVEALS ELEVATED MUSCLE PROTEINS IN PLASMA OF CHILDREN WITH CEREBRAL MALARIA Peter Nilsson1, Julie Bachmann1, Florence Burte2, Setia Pramana3, Ianina Conte2, Mathias Uhlen1, Olugbemiro Sodeinde4, Jochen Schwenk1 Mats Wahlgren3 Delmiro Fernandez-Reyes2 1 KTH - Royal Institute Of Technology 2 National Institute for Medical Research 3 Karolinska Institutet 4 University of Ibadan
210 P-605 COMPARATIVE 2D-DIGE ANALYSIS OF DEPLETED SERUM SAMPLES OF PATIENTS WITH 2009 INFLUENZA A (H1N1). Juan Pablo Reyes Grajeda1, María Isabel Ruiz Olmedo2, Diana I. Aparicio-Bautista1, Rodolfo Ayala Lira1, Diana Ortiz Soriano1, Germán Gutiérrez Campos1, Sergio A. Román-González1, David Escobedo-Ríos1 Mariana Ortiz-Casas3 Nadia Luz López Espinosa3 Victor Manuel Bautista De Lucio3 1 Instituto Nacional De Medicina Genómica (INMEGEN) 2 IFaB S.A. de C.V 3 Institute of Ophthalmology “Fundación de Asistencia Privada Conde de Valenciana”.
P-606 A COMPARISON OF SEVERE AND NON-SEVERE VIVAX MALARIA PATIENTS FOR THE IDENTIFICATION OF DISEASE MONITORING MARKERS USING QUANTITATIVE PROTEOMICS Sandipan Ray1, Sandip Patel1, Vipin Kumar1, Sanjeeva Srivastava1 1 Indian Institute Of Technology Bombay
P-607 THE STAPHYLOCOCCUS AUREUS HG001 PROTEOTYPE RESOURCE Maren Depke1, Stephan Michalik1, Kristin Surmann1, Nico Jehmlich1, Jörg Bernhardt1, Bernd Wollscheid1, Zhi Sun2, Robert Moritz3 Uwe Völker1 Frank Schmidt1 1 University Medicine Greifswald, Greifswald, Germany 2 ETH Zurich, Zürich, Switzerland 3 ISB, Seattle, WA, USA
P-608 SURFACOME CHANGES OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS IN BACTERIAL GROWTH UNDERGOING USNIC TREATMENT BY PROTEOMIC APPROACH Antonella Riviello1, Arianna Pomilio1, Fabrizio Di Giuseppe1,2, Gianni Di Bonaventura1, Marilisa Sulpizio1,2, Stefania Angelucci 1,2, Carmine Di Ilio1,2, Enrica Eleuterio1,2 1 1 School of Medicine and Health- University “G. d’Annunzio” Chieti-Pescara, Aging Research Center, CeSI “University G. d’Annunzio” Foundation”, CHIETI, Italy 2 Stem TeCh Group, CHIETI, Italy
P-609 QUANTITATIVE ANALYSIS OF THE SALIVARY PROTEOME IN HUMAN PAPILLOMAVIRUS (HPV) PATIENTS Marcia Soares1, Isabelle Campanhon1, Leonardo Gomes1, Dennis Ferreira1, Lorena Gonçalves1 1 Ufrj
P-610 A HUMAN PROTEOME MICROARRAY IDENTIFIES THAT THE HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K (HNRNP K) RECOGNIZES THE 5’ TERMINAL SEQUENCE OF THE HEPATITIS C VIRUS RNA Chien-Sheng Chen1 1 National Central University
211 P-611 COMPARATIVE SALIVA PROTEOME OF HEPATITIS B AND C-INFECTED SUBJECTS Lorena Da Ros Gonçalves1, Isabele Champagnon1, Marcia Silva1 1 Universidade Federal Do Rio De Janeiro
P-612 A NOVEL STRATEGY FOR TYPING MYCOPLASMA PNEUMONIAE USING MALDI-TOF MS-CLINPROTOOLS Di Xiao1, Fei Zhao1, Jianzhong Zhang1 1 China CDC
P-613 LABEL-FREE PROTEOMIC ANALYSIS OF ENVIRONMENTAL ACIDIFICATION-INFLUENCED STREPTOCOCCUS PYOGENES SECRETOME REVEALS A NOVEL ACID-INDUCED PROTEIN HISTIDINE TRIAD PROTEIN A (HTPA) INVOLVED IN NECROTIZING FASCIITIS Yao-Tseng Wen1, Jie-Siou Wang1, Shu-Han Tsai1, Chiang-Ni Chuan2, Jiunn-Jong Wu1, Pao-Chi Liao1 1 National Cheng Kung University 2 Chang Gung University
P-614 THIORIDAZINE INDUCES ALTERATIONS IN THE MYCOBACTERIUM TUBERCULOSIS CELL WALL PERMEABILITY BARRIER Jeroen de Keijzer1, Petra de Haas2, Arnoud de Ru1, Peter van Veelen1, Dick van Soolingen1,2 1 Leiden University Medical Centre (LUMC) 2 The National Institute for Public Health and the Environment (RIVM) 3 Radboud University Nijmegen Medical Centre (RUNMC)
P-615 DIFFERENTIAL PROTEOMICS OF ANTIBIOTIC RESISTANCE PROFILING OF ESCHERICHIA COLI FROM CLINICAL SOURCE Luís Pinto1,2,3,4, Patrícia Poeta3,4, Carmen Torres6, Concha García7, Hajer Radhouani1,2,3,4, Júlio Nunes-Miranda1,2, Hugo Santos5, Jose-Luis Capelo-Martinez5 Gilberto Igrejas1,2 1 University Of Trás-Os-Montes And Alto Douro, Vila Real, Portugal 2 Institute for Biotechnology and Bioengineering, Vila Real, Portugal 3 University of Trás-Os-Montes and Alto Douro, Center For Animal Science and Veterinary 4 University of Trás-os-Montes and Alto Douro, Veterinary Science Department 5 Bioscope Group, University of Nova de Lisboa, Faculty of Sciences and Technology, Department of Chemistry 6 University of La Rioja, Biochemistry and Molecular Biology Area 7 Complutense University of Madrid, Department of Microbiology II, Faculty of Pharmacy
P-616 SEROLOGIC PROFILING TO THE CANDIDA ALBICANS INTRACELLULAR PROTEOME FOR THE DIAGNOSIS OF INVASIVE CANDIDIASIS IN NON-NEUTROPENIC PATIENTS Aida Pitarch1, César Nombela1, Concha Gil1 Dep. Microbiology II, Complutense University And IRYCIS, Madrid, Spain
212 P-617 COMBINING NEUCODE WITH LYSC AND LYSN DIGESTION FOR DE NOVO SEQUENCING APPLICATIONS Robert Cunningham1, Kay Opperman1, Christine Johnson2, Ryan Bomgarden1, John Rogers1 1 Thermo Fisher Scientific, Rockford, IL USA 2 Northwestern University, Evanston, IL USA
P-618 FAST AND EFFICIENT CHARACTERIZATION OF BRACHYSPIRA´S PROTEOMA BY ONE-SHOT LC/MS ANALYSIS Vanessa Casas1, Montserrat Carrascal1, José Larrasa2, Santiago Vadillo3, Joaquín Abián1 1 CSIC/UAB Proteomics Laboratory, Bellaterra, Barcelona ,Spain 2 Larrasa Laboratories, La Albuera, Badajoz ,Spain 3 Extremadura University , Spain
P-619 SEMIQUANTITATIVE PROTEOMIC ANALYSIS OF THE INTERACTION BETWEEN CANDIDA ALBICANS AND ACINETOBACTER BAUMANNII Jose Antonio Méndez1, Montserrat Martínez-Gomariz2, Lola Gutiérrez2, Germán Bou1, Concha Gil2 1 Complejo Hospitalario Universitario A Coruña/A Coruña Spain 2 Universidad Complutense de Madrid/Madrid, Spain
P-620 SOLUBLE HLA ISOTYPES AND PEPTIDOME ASSOCIATED WITH HIV PATHOGENESIS Marijana Rucevic1, Majahonkhe Shabangu1, Xu Yang1, Bruce D. Walker1, 2, Sylvie Le Gall1 1 Ragon Institute Of MGH, MIT And Harvard 2 Howard Hughes Medical Institute, Chevy Chase, MD
P-621 SUBCELLULAR FRACTIONATION AND SEVERAL GROWING CONDITIONS TO INCREASE PROTEOME COVERAGE IN CANDIDA ALBICANS PEPTIDEATLAS Vital Vialas1, Maria Luisa Hernaez2, Jose Antonio Reales-Calderon1, Ana Gil de Bona1, Claudia Parra1, Lucia Monteoliva1, Vanesa Casas3, Montserrat Carrascal3, Joaquin Abian3, Zhi Sun4 Eric W Deutsch4, Robert L Moritz4, Concha Gil1,2 1 Universidad Complutense De Madrid , Madrid, Spain 2 Servicio de Proteómica UCM-PCM, Madrid, Spain 3 CSIC/UAB Proteomics Laboratory, Instituto de Investigaciones Biomédicas de Barcelona, Consejo Superior de Investigaciones Científicas, Spain 4 Institute for Systems Biology, Seattle, WA, USA
P-622 EFFECT OF THE GLOBAL REGULATOR CRC IN VESICLE AND VESICLE-FREE EXTRACELLULAR PROTEOME OF PSEUDOMONAS AERUGINOSA Jose Antonio Reales-Calderon1,2, Fernando Corona2, Lucia Monteoliva1, Concha Gil1, Jose Luis Martínez2 1 Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain 2 Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain
213 P-623 A COMPREHENSIVE PROTEOMIC STUDY OF CANDIDA ALBICANS SURFACE AFTER INTERACTION WITH HUMAN SERUM Elvira Marin1, Claudia Parra1, Maria Luisa Hernaez2, Monteoliva Lucia1, Gil Concha1 1 Microbiology II. UCM 2 Proteomic Unit. UCM-PCM
P-624 UNRAVELLING THE PATHOGENESIS PROCESSES OF STAPHYLOCOCCUS PSEUDINTERMEDIUS TOWARD NEW THERAPEUTIC STRATEGIES Joana Martins1, Natacha Couto1,2, Ilídio Magalhães1,3, Miguel Ventosa1,4, Constança Pomba2, Ana Varela Coelho1 1 Instituto De Tecnologia Química E Biológica António Xavier - UNL 2 Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal 3 Departamento Química, Universidade de Aveiro, Aveiro, Portugal 4 IBET, Oeiras, Portugal
P-625 PROTEOMIC CHARACTERIZATION OF HUMAN PROINFLAMMATORY M1 AND ANTI-INFLAMMATORY M2 MACROPHAGES AND THEIR RESPONSE TO CANDIDA ALBICANS. Jose Antonio Reales-Calderón1, Noemí Aguilera-Montilla2, Ángel Luis Corbí2, Gloria Molero1, Concha Gil1 1 Departamento De Microbiología II, Facultad De Farmacia, Universidad Complutense De Madrid, Madrid, Spain 2 Centro De Investigaciones Biológicas, Consejo Superior De Investigaciones Científicas, Madrid, Spain.
214 16 - Standardisation in proteomics
P-626 IMPACT OF GLYCOSYLATION ON ASSIGNING PROTEIN MASS VALUES AND THEIR TRACEABILITY Amalia Muñoz, Virginie Tregoat EC-JRC-IRMM
P-627 HIGH-ACCURACY, LABEL-FREE QUANTITATION OF HUMAN PLASMA PROTEINS FOR ESTIMATION OF BLOOD-DERIVED PROTEINS INCLUDED IN CLINICAL TISSUE SPECIMENS Yutaka Yoshida1, Masato Habuka1, 2, Ying Zhang1, Bo Xu1, Sameh Magdeldin1, 3, Eishin Yaoita1, Tadashi Yamamoto, 1 Niigata University, Niigata, Japan 2 Science for Life Laboratory, Stockholm, Sweden 3 Suez Canal University, Ismailia, Egypt
P-628 COMPARISON OF METHODS FOR THE QUANTIFICATION OF STABLE ISOTOPE LABELLED PROTEIN AND PEPTIDE STANDARDS FOR QUANTITATIVE PROTEOMICS Christopher Pynn1, Benedikt Lang2, Martin Gamer3, Sandra Maier2, Peter Schultz-Knappe3, Bart van den Berg2, Oliver Poetz2, Dieter Stoll1 1 Albstadt-Sigmaringen University Of Applied Sciences 2 NMI- Natural and Medical Sciences Institute at the University of Tuebingen 3 Protagen AG
P-629 COMPARISON OF DESALTING METHODS FOR PROTEOMIC ANALYSIS OF WHOLE SALIVA AS AN EXAMPLE FOR HUMAN BIOFLUIDS Annette Murr1, Claas Golatowski1, Manuela Gesell Salazar1, Vishnu Mukund Dhople1, Elke Hammer1, Uwe Voelker1, Nico Jehmlich1,2 1 Interfaculty Institute For Genetics And Functional Genomics, University Medicine Greifswald, Germany 2 Helmholtz-Centre for Environmental Research – UFZ, Leipzig, Germany
P-630 PROTEOSUITE - STANDARD SUPPORTING SOFTWARE FOR QUANTITATIVE ANALYSIS Faviel Gonzalez1, Andrew Collins1, Simon Perkins1, Huaizhong Zhang2, Jun Fan3, Conrad Bessant3, Andrew Dowsey2, Henning Hermjakob4 Simon Hubbard2 Andrew Jones1 1 University of Liverpool 2 University of Manchester 3 Queen Mary University of London 4 European Bioinformatics Institute
P-631 EVALUATION OF STAIN-FREE SDS-PAGE FOR GELC-MS APPLICATIONS Sricharan Bandhakavi1, Michael Early1, Kate Smith1, Todd Markowski2 1 BiP-Rad Laboratories, Hercules, CA, USA 2 University of Minnesota, Minneapolis, MN, USA
215 P-632 ELIMINATING WESTERN BLOT VARIABILITY WITH SALLY SUE Patricia Piatti, Andrea Tu, Suparna Mundodi, Jessica Dermody, Irina Kazakova, Francisco Ramirez, Uyen Nguyen, Hui Xui, Annegret Boge ProteinSimple
P-633 INTEGRATED WORKFLOW FOR PROTEIN PURIFICATION/FRACTIONATION BY NGC SYSTEM AND VISUALIZATION BY STAIN-FREE SDS-PAGE Kate Smith, Jonathan Kohn, Jeff Habel, Sricharan Bandhakavi, Kiranjot Kaur BiP-Rad Laboratories
P-634 THE EFFECTS OF PREANALYTICAL VARIABLES ON SERUM PEPTIDOME PROFILING BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY Sachio Tsuchida1, Mamoru Satoh1, Kazuyuki Sogawa1, Hiroshi Umemura1, Minako Beppu2, Setsu Sawai2, Motoi Nishimura2, Yoshio Kodera3 Kazuyuki Matsushita2 Fumio Nomura2 1 Clinical Proteomics Research Center, Chiba University Hospital 2 Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University 3 Laboratory of Biomolecular Dynamics, Department of physics, School of Science, Kitasato University
P-635 SYSTEMATIC COMPARISON OF SDS-PAGE AND HIGH-PH RPLC FRACTIONATION METHODS Xuefei Yin, Yang Zhang, Xiaohui Liu, Huali Shen, Haojie Lu, Pengyuan Yang Department of chemistry and Institutes of Biomedical Sciences of Shanghai medical School, Fudan Univ.
P-636 A SIMPLE PROTOCOL TO ROUTINELY ASSESS THE UNIFORMITY OF PROTEOMICS ANALYSES Adele Bourmaud, Sebastien Gallien, Bruno Domon Luxembourg Clinical Proteomics Center, Strassen, Luxembourg
P-637 NORMALIZATION OF CAPTURE PROBE CONCENTRATION USING A FLUORESCENT CALIBRANT IMPROVES ANTIBODY MICROARRAY REPRODUCIBILITY Veronique Laforte1, David Juncker1,2 1 Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada 2 Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada
P-638 COMPARATIVE PROTEOMIC ANALYSIS OF AQUEOUS HUMOR FROM HUMAN EYES AFTER CATARACT SURGERY AND FROM POST-MORTEM EYES WITHOUT OPHTHALMIC DISEASES Anna Bugrova1, Alexey Kononokhin1,3, Elena Verigo2, Natalia Starodubtseva1,4, Igor Popov1,3, Grigori Kalamkarov1, Eugeny Nikolaev1,3 1 Emanuel Institute of Biochemical Physics RAS, Moscow, Russia 2 Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia 3 Institute for Energy Problems of Chemical Physics RAS, Moscow, Russia
216 4 Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia P-639 THE NASAL FLUID PROTEOME IN HEALTHY CHILDREN Luis Teran1, Xinping Li2, Thomas Franz3 1 Instituto Nacional Enfemedades Respiratorias, Mexico 2 MPI For Biology of Ageing, Cologne Germany
P-640 QUICK AND CLEAN PEPTIDE MAPPING USING ULTRAFAST LC-MS SAMPLE DELIVERY SYSTEM Michael Blank1, John Rogers2, Robert Cunningham2, Michael Andersen3, Nikolai Bache3, Rosa Viner1, Andreas Huhmer1, Christian Ravnsborg3 Stefan Stromereder3 1 Thermo Fisher Scientific, San Jose CA, USA 2 Thermo Fisher Scientific, Rockford IL, USA 3 Thermo Fisher Scientific, Germering, Germany
P-641 PROCESS – PROTEOMICS DATA COLLECTION, SOFTWARE AND STANDARDS TO SUPPORT OPEN ACCESS AND LONG TERM MANAGEMENT OF DATA. Simon Perkins1, Henning Hermjakob2, Andy Jones1 1 University Of Liverpool, Liverpool, United Kingdom 2 European Bioinformatics Institute, Cambridge, United Kingdom
P-642 A HIGH-THROUGHPUT AND REPRODUCIBLE WORKFLOW TO PREPARE HUMAN PLASMA SAMPLES FOR PROTEOMIC ANALYSIS Qin Fu1, 2, Michael Kowalski3, Eric Grote2, Pingbo Zhang2, Xiaoquan Liu1, 2, Graham Threadgill4, Christie Hunter5, Jennifer Van Eyk1, 2 1 Cedars Sinai Medical Center 2 Johns Hopkins Bayview Proteomics Center 3 Beckman Coulter Life Sciences 4 Beckman Coulter 5 AB SCIEX
P-643 AN AUTOMATED WORKFLOW SOLUTION FOR IDENTIFICATION AND QUANTIFICATION OF PROTEOMES Xiaoyue Jiang, Daniel Lopez Ferrer, Andreas Hühmer Thermo Fisher Scientific
P-644 THE VALUE OF SUBCELLULAR FRACTIONATION IN PROTEOMIC STUDIES Manuel Fuentes, Paula Diez, Maria Gonzalez-Muñoz, Nieves Ibarrola, Rosa Mª Degano, Alberto Orfao Cancer Research Center. University Of Salamanca-CSIC
217 P-645 COMBINED PROTEOMIC AND METABOLOMIC ANALYSIS APPROACHES TO INVESTI- GATE THE MODIFICATION IN THE PROTEOME AND METABOLOME OF IN VITRO MODELS TREATED WITH GOLD NANOPARTICLES (AUNPS) Hubert Chassaigne1, Sabrina Gioria1, Joana Lobo Vicente1, Donatella Carpi2, Paola Barboro3, Giorgio Tomasi4, Agnieszka Kinsner-Ovaskainen1, François Rossi1 1 European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Via Enrico Fermi 2749, I-21027 Ispra, Italy 2 INGM Istituto Nazionale di Genetica Molecolare, Via Francesco Sforza 28, I-20122 Milan, Italy 3 IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi 10, I-16132 Genova, Italy 4 University of Copenhagen, Nørregade 10, DK-1017 Copenhagen, Denmark
P-646 VARIABILITY OF 15N METABOLIC LABELING-BASED PROTEOMIC WORKFLOWS IN MOUSE SPECIMENS. Michaela Filiou, Magdalena Soukupova, Christiane Rewerts, Christian Webhofer, Chris Turck, Giuseppina Maccarrone Max Planck Institute Of Psychiatry, Munich, Germany
P-647 EVALUATION OF MASS SPECTROMETER PERFORMANCES USED IN LARGE-SCALE PRO- TEOMICS Claire Ramus1,4, Agnès Hovasse3,4, Marlène Marcellin2,4, Anne-Marie Hesse1,4, Sebastian Vaca3,4, Sarah Cianférani3,4, Christine Schaeffer3,4, Yohann Couté1,4 Anne Gonzalez de Peredo2,4 Jérôme Garin1,4 1 U1038 INSERM/CEA/UJF, iRTSV, CEA Grenoble, France 2 IPBS, CNRS UMR5089, Université de Toulouse, France 3 IPHC-DSA, CNRS, UMR7178, Strasbourg, France 4 ProFi, Proteomic French Infrastructure
P-648 SUCCESS VIA STANDARDISATION – BRINGING RELIABILITY TO CLINICAL PROTEOMIC BIOMARKER DISCOVERY Ben Chaffey, Will Dracup, David Bramwell Biosignatures Ltd
P-649 CONFIRMING THE REMARKABLE IMPROVEMENT IN LC-MS SENSITIVITY FOR PROTEOMICS BESTOWED BY DIMETHYLSULFOXIDE AS A LC SOLVENT ADDITIVE Andrew Thompson, Amandeep Bhamra, Marcella Widya, Sarah Hanrahan The Institute Of Cancer Research
P-650 MZQ LIBRARY -- AN OPEN SOURCE JAVA LIBRARY FOR SUPPORTING QUANTITATIVE PROTEOMICS STANDARD Da Qi1, Jun Fan2, Huaizhong Zhang3, Simon Hubbard3, Conrad Bessant2, Andrew Jones1 1 Institute Of Integrative Biology, University Of Liverpool 2 The School of Biological and Chemical Sciences, Queen Mary University of London 3 The Faculty of Life Sciences, University of Manchester
218 P-651 MASS SPECTROMETRY-BASED PROTEOMICS AS TOOL FOR THE QUALITY CONTROL OF INTRAVENOUS IMMUNOGLOBULIN. Franck T.M Limonier WIV-ISP (Public Health Institute of Belgium), Bussels, Belgium
219 17 - Cardiovascular and haematological proteomics
P-652 RELATIOSHIP OF OSTEONECTIN LEVEL WITH INFLAMMATORY, OXIDATIVE AND LIPID BIOMARKERS IN BLOOD IN CORONARY ATHEROSCLEROSIS AND ITS COMPLICATION Yulia Ragino1, Elena Kashtanova1, Alexandr Chernjavski2, Yana Polonskaia1, Mikhail Voevoda1 1 Institute Of Internal And Preventive Medicine SB RAMS 2 Institute Of Circulation Pathology MH of RF
P-653 HALLMARKS OF INFLAMMATION, PROTEOLYSIS AND OXIDATIVE STRESS IN THE HDL PARTICLES FROM HUMAN ABDOMINAL AORTIC ANEURYSM PATIENTS Inmaculada Jorge1, Elena Burillo2, Luis Blanco-Colio2, Emilio Camafeita1, Raquel Mesa1, Marco Trevisan-Herraz1, Juan Carlos Silla-Castro1, Elena Bonzon-Kulichenko1 Jesús Ejido2 Olivier Meilhac3 Jose Luis Matín Ventura2 Jesús Vázquez 1 Centro Nacional De Investigaciones Cardiovasculares, Madrid, Spain 2 Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain 3 Hôpital Bichat, Paris, France
P-654 THE SEARCH FOR HEART SECRETORY PROTEINS AS HEART DISEASE BIOMARKERS Toshinobu Ogura1, 2, Yohei Mukai1, 2, Makiko Maeda1, Yasushi Fujio1, 3, Yasushi Sakata3, Kazuma Higashisaka1, 2, Yasuo Yoshioka1, 2, 4, Kazuya Nagano1,2 Haruhiko Kamada1, 2, 4 Shin-Ichi Tsunoda1, 2, 4 Yasuo Tsutsumi1, 2, 4 1 Graduate School Of Pharmaceutical Sciences, Osaka University, Osaka, Japan 2 National Institute of Biomedical Innovation, Osaka, Japan 3 Graduate School of Medicine, Osaka University, Osaka, Japan 4 MEI center, Osaka University, Osaka, Japan
P-655 HIGH-THROUGHPUT LC-MS MRM ANALYSIS OF CALCYCLIN IN PRE-ECLAMPSIA PATIENT SERA Coskun Güzel1, Lennard Dekker1, Johannes Vissers2, Gerda Zeeman3, Eric Steegers3, Theo Luider1 ErasmusMC, Department of Neurology, Rotterdam, The Netherlands Waters Corporation, Wilmslow, UK ErasmusMC, Department of Gynaecology, Rotterdam, The Netherlands
P-656 URINARY QUANTITATIVE PROTEOMIC REVEALS NEPHRIN 1 AS A MARKER OF SALT SENSITIVE HYPERTENSION IN HUMANS Vittoria Matafora1, Laura Zagato, Paolo Manunta, Giovambattista Capasso, Angela Bachi 1 IFOM- FIRC Institute Of Molecular Oncology 2 Division of Genetics & Cell Biology, San Raffaele Scientific Institute 3 Division of Genetics & Cell Biology, San Raffaele Scientific Institute 4 Department of Internal Medicine, Second University of Naples 5 IFOM- FIRC Institute Of Molecular Oncology
220 P-657 DIFFERENTIAL PROTEOMIC SIGNATURE IN CHRONIC CORONARY ARTERY DISEASE PATIENTS WITH AND WITHOUT A RECURRENT ACUTE EVENT Judit Cubedo*1, José Tuñón*2, Nieves Tarín3, Carmen Cristóbal4, Ana Huelmos5, Teresa Padró1, Lina Badimon1 1 Cardiovascular Research Center (CSIC-ICCC); Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain 2 Cardiology Department Jimenez Diaz Foundation, Madrid, Spain 3 University Hospital of Móstoles, Madrid, Spain 4 Fuenlabrada Hospital, Madrid, Spain 5 University Hospital Alcorcón Foundation, Madrid, Spain
P-658 ELUCIDATING THE RELATIONSHIP BETWEEN CALCIFIC AORTIC STENOSIS AND ATHEROSCLEROSIS: A COMPREHENSIVE PROTEOMIC STUDY IN AORTIC VALVE TISSUE Laura Mourino-Alvarez1, Fernando de la Cuesta1, Tamara Sastre-Oliva1, Montserrat Baldan-Martin1, Luis F. Lopez-Almodovar2, Esther Rosello-Lleti3, Miguel Rivera3, Pedro Luis Sanchez4 Luis R. Padial2 Maria G. Barderas1 1 Hospital Nacional De Parapléjicos, Toledo, Spain 2 Hospital Virgen de la Salud, Toledo, Spain 3 Health Research Institute Hospital La Fe, Valencia, Spain 4 Hospital General Universitario Gregorio Marañon, Madrid, Spain
P-659 PROTEOMIC CHARACTERIZATION OF HUMAN CORONARY THROMBUS IN PATIENTS WITH ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION: RIGHT TO THE EPICENTRE OF THE PATHOGENESIS Fernando De La Cuesta1, Rafael Moreno-Luna1, Sergio Alonso-Orgaz1, Laura Mourino-Alvarez1, Montserrat Baldan-Martin1, Tamara Sastre-Oliva1, Juan A. Lopez2, Luis R. Padial3 Jose Moreu4 Maria G. Barderas1 1 Department Of Vascular Physiopathology, Hospital Nacional De Paraplejicos SESCAM, Toledo 2 Unidad de Proteomica, CNIC, Madrid 3 Department of Cardiology, Hospital Virgen de la Salud, SESCAM, Toledo 4 Department of Hemodynamics, Hospital Virgen de la Salud, SESCAM, Toledo
P-660 ITRAQ: A STRATEGY FOR BIOMARKER PROFILING IN AORTIC STENOSIS DISEASE Tatiana Martin-Rojas1, Laura Mourino-Alvarez1, Fernando de la Cuesta1, Sergio Alonso-Orgaz1, Tamara Sastre-Oliva1, Luis F. Lopez-Almodovar2, Enrique Calvo3, Luis R. Padial2 Juan Antonio Lopez3 Maria G. Barderas1 1 Hospital Nacional De Parapléjicos, Toledo, Spain 2 Hospital Virgen de la Salud, Toledo, Spain 3 CNIC, Madrid, Spain
221 P-661 A CHARACTERISTIC PROTEOMIC AND METABOLOMIC PROFILE IN BLOOD PLASMA WITH UTILITY IN PREDICTING EVOLUTION OF PATIENTS WITH ARTERIAL HYPERTENSION TO ALBUMINURIA Montserrat Baldan-Martin1, Rafael Moreno-Luna, Gloria Alvarez-Llamas, Laura Gonzalez-Calero, Juan Antonio Lopez, Jesus Vazquez, Fernando Vivanco, Luis M. Ruilope, Fernando de la Cuesta, Maria G. Barderas 1 Hospital Nacional De Paraplejicos, Madrid, Spain 2 IIS-Fundacion Jimenez Diaz, Madrid, Spain 3 CNIC, Madrid, Spain 4 IIS-Hospital 12 de Octubre, Madrid, Spain
P-662 PROTEIN CONSTITUENCY OF LIPOPROTEINS DETERMINED BY RECONSTRUCTION OF SIZE FRACTION PROFILES COMBINED WITH SHOTGUN PROTEOMICS Jon Rees1, John Barr1, Susan Kuklenyik1, David Schieltz1, Yulanda Williamson1, Lisa McWilliams1, Michael Gardner1, 1 Centers For Disease Control And Prevention
P-663 SIMPLIFICATION STRATEGIES FOR THE CARDIAC PROTEOME Bethany Geary1, Kieran Magee2, Iain Young2, Phillip Cash3, Phillip Whitfield1, Mary Doherty1 1 Department of Diabetes and Cardiovascular Science, University Of The Higlands And Islands, Inverness, United Kingdom 2 Institute of Integrative Biology, University of Liverpool, United Kingdom 3 Division of Applied Medicine, University of Aberdeen, United Kingdom
P-664 EXPLORING THE DYNAMICS OF THE ZEBRAFISH HEART PROTEOME Bethany Geary1, Kieran Magee2, Iain Young2, Phillip Cash3, Phillip Whitfield1, Mary Doherty1 1 Department of Diabetes and Cardiovascular Science, University Of The Higlands And Islands, Inverness, United Kingdom 2 Institute of Integrative Biology, University of Liverpool, United Kingdom 3 Division of Applied Medicine, University of Aberdeen, United Kingdom
P-665 SEPSIS ASSOCIATED GLYCOPROTEINS IN PLASMA Yuan Tian1,2,3, Ashley Decoux1,2,3, Elizabeth Flynn1,2,3, Alan Jones2,4, Merry Lindsey1,2,3,5, Michael Puskarich2,4 1 San Antonio Cardiovascular Proteomics Center 2 Mississippi Center for Heart Research 3 Department of Physiology and Biophysics, University of Mississippi Medical Center 4 Department of Emergency Medicine, University of Mississippi Medical Center 5 Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center
222 P-666 VINNCARDIO: HIGH-THROUGHPUT SCREENING FOR PLASMA BIOMARKERS IN CARDIOVASCULAR DISEASE Maria Jesus Iglesias Mareque1, Elin Birgersson1, Mun-Gwan Hong1, Kimi Drobin1, Eni Andersson1, Andrea Ganna2, Peter Nilsson1, Mathias Uhlén1 Jacob Odeberg1,3,4 Jochen Schwenk1 1 Science for Life Laboratory – Royal Institute of Technology (KTH), Stockholm, Sweden 2 Molecular Epidemiology, Uppsala University Hospital, Sweden 3 Centre for Hematology Karolinska (HCK), Karolinska Institutet, Stockholm, Sweden 4 Centre for Molecular Medicine (CMM), Karolinska Institutet, Sweden
P-667 PROTEOMIC ANALYSIS OF LEFT VENTRICULAR TISSUES IN DILATED CARDIOMYOPATHY Mitsuhiro Nishigori1, Hiroaki Yagi1, Sayaka Muto1,2, Kazuki Sasaki1, Masanori Asakura3, Osamu Seguchi4, Takeshi Nakatani4, Yoshihiko Ikeda2 Hatsue Ishibashi-Ueda2 Naoto Minamino1 1 Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center Research Institute 2 Department of Pathology, National Cerebral and Cardiovascular Center Hospital 3 Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Hospital 4 Department of Transplantation, National Cerebral and Cardiovascular Center Hospital
P-668 IDENTIFICATION OF A URINE MOLECULAR FINGERPRINT WHICH RESPONDS TO ALBUMINURIA CONDITION AND PROGRESSION IN HYPERTENSIVE PATIENTS CHRONICALLY RAAS SUPPRESSED Laura Gonzalez-Calero1, Marta Martin-Lorenzo1, Aroa S. Maroto1, Maria Posada-Ayala1, Montserrat Baldan-Martin2, Fernando de la Cuesta2, Maria G. Barderas2, Luis M. Ruilope3 Gloria Alvarez-Llamas1 Fernando Vivanco1,4 1 Immunology Department, IIS-Fundacion Jimenez Diaz, Madrid (Spain) 2 Vascular Physiopathology Department, Hospital Nacional de Paraplejicos (HNP), SESCAM, Spain 3 Cardiovascular risk and Hypertension Department. IIS-Hospital 12 de Octubre, Madrid 4 Department of Biochemistry and Molecular Biology I, Universidad Complutense, Madrid, Spain
P-669 MOLECULAR ALTERATIONS IN HUMAN URINE REVEAL ATHEROSCLEROSIS DEVELOPMENT AND CARDIOVASCULAR EVENT AT ONSET AND FOLLOW-UP. Marta Martin-Lorenzo1, Irene Zubiri1, Aroa S. Maroto1, Laura Gonzalez-Calero1, Maria Posada-Ayala1, Fernando de la Cuesta2, Luis R. Padial3, Maria G. Barderas2 Fernando Vivanco1, 4 Gloria Alvarez-Llamas1 1 IIS-Fundacion Jimenez Diaz, Madrid, Spain 2 Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain 3 Hospital Virgen de la Salud; SESCAM, Toledo, Spain 4 Universidad Complutense, Madrid, Spain
P-670 THE DIRECT EFFECT OF CORTISOL ON CA2+ REGULATORY PROTEINS IN THE HEART Nari Kim1, Sung-Ryul Lee1, Tae- Hee Ko1, Hyoung Kyu Kim1, Kyung Soo Ko1, Byoung-Doo Lee1, Jin Han1, Sora Lee1 1 Cardiovascular And Metabolic Disease Center
223 P-671 MULTIPLE PTMS PLAY A ROLE IN THE REGULATION OF PLATELETS IN HEALTH AND DISEASE Florian Beck1, A. Saskia Venne1, Julia Burkhart1, Marc Vaudel1,2, Lennart Martens3, Ulrich Walter4, Johan W. Heemskerk5, Albert Sickmann1 René P. Zahedi1 1 Leibniz–Institut Für Analytische Wissenschaften - ISAS, Dortmund, Germany 2 Proteomics Unit, Department of Biomedicine, University of Bergen, Norway 3 VIB Ghent University, Ghent, Belgium 4 Center for Thrombosis and Hemostasis CTH, Wuerzburg, Germany 5 CARIM, Maastricht University, The Netherlands
P-672 ALTERED PHOSPHORYLATION PROFILE OF SCOTT SYNDROME PLATELETS REVEALED BY QUANTITATIVE PHOSPHOPROTEOMICS Nadine J.A Mattheij1, Fiorella A. Solari2, Julia M Burkhart2, Frauke Swieringa1, Peter W Collins3, Judith M.E.M Cosemans1, Albert Sickmann2, Johan W.M Heemskerk1 René P. Zahedi1 1 Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands 2 Leibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany 3 Arthur Bloom Haemophilia Centre, School of Medicine, Cardiff University, Cardiff, United Kingdom
P-673 THE REGENERATIVE ABILITIES OF RESIDENT CARDIAC STEM CELLS DEPENDS ON SECRETED PARACRINE FACTORS Sunjay Kaushal1, Rachana Mishra1, Sudhish Sharma1 University Of Maryland
P-674 CHARACTERIZING QUALITATIVE AND QUANTITATIVE GLOBAL CHANGES IN THE AGING HEART USING PSMART, A NOVEL ACQUISITION METHOD Maryann S. Vogelsang1, Amol Prakash1, David Sarracino1, Gouri Vadali1, Scott Peterman1, Barbara Frewen2, Aliya Nussupbekova3, Aibek Smagul3 Yueqiang Zhao2 Shadab Ahmad1 Gregory Byram1 Bryan Krastins, Victoria V Lunyak, Mary F Lopez 1 BRIMS, Thermo Fisher Scientific, Cambridge, MA, USA 2 Buck institute for Research on Aging, Novato, CA, USA 3 Buck institute for Research on Aging, Novato, CA, USA and Kazakh Medical University, Almaty, Kasakhstan
P-675 COMBINING MULTIPLE PROTEOMIC APPROACHES IN THE STUDY OF ATHEROSCLEROSIS: A NOVEL MECHANISM OF PLATELET-MONOCYTE INTERACTIONS Juergen Kast1, Ru Li1, Jiqing Huang1, Chengcheng Zhang1 1 University Of British Columbia
P-676 THE ROLE OF BLOOD INTENSITY IN EXPRESSION AND GLYCOSYLATION OF LDLR IN ENDOTHELIAL CELLS Gabriela Venturini1, Rafael Dariolli1, Valdemir Melechco Carvalho2, Jéssica Silva Salgueiro2, Karina Helena Morais Cardozo2, José Eduardo Krieger1, Alexandre da Costa Pereira1 1 Incor, USP 2 Fleury Group
224 P-677 SYSTEMATIC CHARACTERIZATION OF HUMAN PLATELETS IN CARDIOVASCULAR DISORDERS BY QUANTITATIVE PROTEOMICS Kristin Becker1, Thomas W.D. Möbius1, Sebastian Malchow1, Monika Stoll2, Bernhard Schieffer3, Julia M. Burkhart1, Albert Sickmann1, 1 Leibniz-Institut Für Analytische Wissenschaften – ISAS – e.V., Dortmund, NRW, Germany 2 Leibniz-Institut für Arterioskleroseforschung, Universität Münster, NRW, Germany 3 Klinik für Kardiologie und Angiologie, Philipps-Universität Marburg, Hessen, Germany
P-678 ENDOMYOCARDIAL PROTEIN PROFILING OF DCM PATIENTS WITH DIFFERENT RESPONSE TO IMMUNOADSORPTION THERAPY Gourav Bhardwaj1, Sabine Ameling1, Vishnu Dhople1, Marcus Dörr2, Karin Klingel3, Stephan Felix2, Uwe Völker1, Elke Hammer1 1 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany 2 Department of Internal Medicine B, University Medicine Greifswald, Germany 3 Department of Molecular Pathology, University Hospital Tübingen, Germany
P-679 PROFILING OF PLATELET PROTEIN IN CIRCULATION OF DIABETIC PATIENTS: IN VITRO EFFECT OF ISOLATED PLATELET-SPECIFIC PROTEIN MIXTURE ON ENDOTHELIAL CELLS Anugya Bhatt1, Serene Hilary1, Jothydev Kesavadev2, Lissy Krishnan1 1 Sctimst 2 Jothydev Diabetic Clinic
P-680 A 2D-DIGE-BASED PROTEOMIC ANALYSIS REVEALS DIFFERENCES IN THE PLATELET RELEASATE DEPENDING ON THE PLATELET STIMULUS Paula Vélez1,2, Isaac Rosa1,2, Ángel García1,2 1 Platelet Proteomics Group. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Spain 2 Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain
P-681 ESTABLISHMENT OF PROTEIN PROFILE-BASED STAGE CLASSIFICATION FOR AORTIC ANEURYSM Hiroaki Yagi1, Hiromitsu Nishigori1, Tsukasa Osaki1, Kazuki Sasaki1, Sayaka Muto1, Takayuki Morisaki1, Kenji Minatoya2, Hatsue Ishibashi-Ueda2 Naoto Minamino1 1 National Cerebral And Cardiovascular Center Research Institute 2 National Cerebral and Cardiovascular Center Hospital
P-682 INTEGRATED PROTEOMIC AND METABOLOMIC ANALYSIS REVEALS THE ROLE OF DYSSYNCHRONY IN METABOLIC REMODELING IN TACHYPACING-INDUCED HEART FAILURE Sarah Franklin1, Alexey Zaitsev1, Frank Sachse1, Justin Lichter1, Hui Li1, Tatiana Yuzyuk1, Mickey Miller1, Aman Makaju1 Junko Shibayama1 1 University Of Utah
225 P-683 MRM ASSAY DEVELOPMENT WITH APPLICATION TO BIOBANK SAMPLES FROM PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Melinda Rezeli1, Ákos Végvári1, Maria Yakovleva1, Olof Gidlöf2, Gustav Smith2, Pontus Andell2, David Erlinge2, György Marko-Varga1 1 Lund University, Lund, Sweden 2 Skåne University Hospital, Lund, Sweden
P-684 THE COMPARATIVE SECRETOME OF HUMAN HEPATIC HUH7 CELLS IN THE PRESENCE OF B-ESTRADIOL AND ITS AFFECT ON THE SECRETED PCSK9 INTERACTOME Janice Mayne1, Omar Anjum1, Amanda E. Starr1, Zhibin Ning1, Michel Chretien1, Daniel Figeys1 1 University Of Ottawa
P-685 QUANTITATIVE PROTEOME ANALYSIS OF SECTIONS OF FORMALIN FIXED-PARAFFIN EMBEDDED ARTERIAL SAMPLES FROM PATIENTS WITH TYPE 2 DIABETES: METFORMIN TREATMENT NORMALIZES ARTERIAL MATRIX COMPOSITION IN TYPE 2 DIABETES Hans C. Beck1, Simone A.R. Preil1, Lars P. Kristensen1, Pia S. Jensen1, Marina Bjørling-Poulsen1, Maria L. Hansen1, Torben S. Steiniche2, Martin R. Larsen3 Lars M. Rasmussen1 1 Odense University Hospital 2 University Hospital of Aarhus 3 University of Southern Denmark
P-686 CARDIAC PROTEOMIC PROFILING IDENTIFIES NOVEL PLASMA MEMBRANE PROTEINS THAT REGULATE CARDIAC FUNCTION Parveen Sharma1, Cynthia Abbasi2, Melissa Noronha2, Savo Lazic2, Peter Liu3, Gordon Keller4, Igor Stagljar2, Ian Scott2 Thomas Kislinger2 Anthony Gramolini2 1 University Of Liverpool, Liverpool, UK 2 University Of Toronto, Toronto, Ontario, Canada 3 Toronto General Hospital, University Health Network, Toronto, Ontario, Canada 4 McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON, M5G 1L7, Canada
P-687 EXPLORING PROTEOMICS TOOLBOX TOWARDS HUMAN CARDIAC STEM CELLS CHARACTERIZATION Patrícia Gomes-Alves1,2, Raquel Cunha1,2, Margarida Serra1,2, Marcos Sousa1,2, Catarina Brito1,2, Luís Rodriguez-Borlado3, Juan A., Jesús López Vázquez4, António Bernad4 Manuel J. Carrondo1,2, 5 Paula M. Alves1,2 1 iBET, Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal 2 Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal Coretherapix, Madrid, Spain 3 CNIC, Madrid, Spain 4 Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Monte da Caparica, Portugal
226 P-688 QUANTITATIVE PROTEIN ANALYSIS OF ENDOTHELIAL PROGENITOR CELLS IN ATHEROSCLEROSIS Violette Gautier1, 2, Francisco Vega3, Cecilia Fernandez-Ponce4, Ana B García4, Alipio Mangas4, Francisco García-Cozar4, Arjen Scholten1,2, Albert JR Heck1,2 Mª Carmen Duran4 1 Utrecht University, Utrecht, The Netherlands 2 Netherlands Proteomics Centre, Utrecht, The Netherlands 3 Institute of Biomedicine of Seville, Spain 4 Cadiz University,Cadiz, Spain
P-689 PROTEOMIC PROFILING OF THE HUMAN VENOUS EXTRACELLULAR MATRIX REVEALS A ROLE FOR MAST CELL PROTEASES IN THE PATHOGENESIS OF VARICOSE VEINS Xiaoke Yin1, Rahmi Oklu2, Javier Barallobre-Barreiro1, Marika Fava1,3, Hassan Albadawi2, Sarah R. Langley1, Marjan Jahangiri3, Michael T. Watkins2 Sanjay Misra4 Manuel Mayr1 1 King’s BHF Centre, King’s College London, London, UK 2 Harvard Medical School, Boston, Massachusetts, US 3 St. George’s, University of London, London, UK 4 Mayo Clinic, Rochester, Minnesota, US
P-690 PREDICTIVE BIOMARKERS FOR INCREASED RISK OF ARRHYTHMIC DEATH IN THE PREDICTION OF ARRHYTHMIC EVENTS IDENTIFIED BY LARGE-SCALE PLASMA PROTEOMICS PROFILING Jun Qu1, Rebbacah Yang1, Xiaomeng Shen1, Yang Qu1, John Canty1 SUNY-Buffalo
227 18 - Neurological disorders
P-691 INNATE AND ADAPTIVE IMMUNE SYSTEM ALTERATIONS IN PRE-MANIFEST STAGES OF TRANSGENIC PORCINE MODEL OF HUNTINGTON’S DISEASE Karla Jarkovska1, Eva Kotrcova1, Ivona Valekova1, Suresh Jivan Gadher2, Hana Kovarova1 1 Institute Of Animal Physiology And Genetics AS CR, v.v.i., Libechov, Czech Republic 2 Thermo Fisher Scientific, Frederick, USA
P-692 ALTERATIONS OF PROTEIN COMPOSITION ALONG THE ROSTRP-CAUDAL AXIS AFTER SPINAL CORD INJURY: PROTEOMIC ANALYSES Stéphanie Devaux1,2, Dasa Cizkova2, Françoise Le Marrec-Croq1, Julien Franck1, Lucia Slovinska2, Juraj Blasko2, Miriam Nagyova2, Christophe Lefebvre1 Isabelle Fournier1 Michel Salzet1 1 Laboratoire Spectrométrie De Masse Biologique Fondamentale Et Appliquée, Université Lille1 2 Institute of Neurobiology, Slovak Academy of Sciences
P-693 DIFFERENTIAL PROTEOMICS OF HUMAN CSF FROM TRAUMATIC SPINAL CORD INJURY PATIENTS REVEALS PERTURBED MOLECULAR PATHWAYS IN SECONDARY INJURY PHASE Mohor Sengupta1, Mahashweta Basu1, Sourav Ishwarari2, Kiran Mukhopadhyay2, Krishnapada Sardar2, Biplab Acharyya2, Pradeep Mohanty1, Debashis Mukhopadhyay1 1 Saha Institute Of Nuclear Physics 2 NRS Medical College Hospital, Kolkata
P-694 QUANTITATIVE PROTEOMICS OF HUMAN LRRK2 (R1441C) DROSOPHILA MODEL OF PARKINSON DISEASE Md. Shariful Islam1,2, Hendrik Hannes Nolte2, Marcus Krãger2, Bernhard Hovemann4, Rolf Heumann3, Hermann Heumann1 1 Silantes GmbH, Munich, Germany 2 Max Plank Institute For Heart And Lung, BadNauheim, Germany 3 Molecular neurobiochemistry, Ruhr-University Bochum, Germany 4 Department of Molecular Cell Biochemistry, Ruhr-University Bochum, Germany
P-695 INDUCTION MECHANISM OF NEURAL DIFFERENTIATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS BY ELECTROMAGNETIC FIELD Chan-Wha Kim, Han-Na Lee Korea University
228 P-696 A PROTEOMICS PERSPECTIVE ON NEURODEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS Daniel Hornburg1, Stephanie May2, Carsten Drepper3, Falk Butter5, Felix Meissner1, Dieter Edbauer2, Michael Sendtner4, Matthias Mann1 1 Max Planck Institute of Biochemistry, Martinsried, Germany 2 German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. 3 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, Wuerzburg, Germany 4 Institute for Clinical Neurobiology, Wuerzburg, Germany 5 Institute of Molecular Biology (IMB), Mainz, Germany
P-697 USE OF MULTIPLE REACTION MONITORING LC-MS FOR THE VERIFICATION OF PARKIN- SON’S DISEASE PROTEIN SIGNATURES Tiziana Alberio1,2, Kelly McMahon3, Lee Gethings3, Manuela Cuccurullo4, Craig Lawless5, Maurizio Zibetti6, Leonardo Lopiano6, Johannes Vissers3 Mauro Fasano1,2 1 Department of Theoretical and Applied Sciences, University of Insubria, Italy 2 Center of Neuroscience, University of Insubria, Italy 3 Waters Corporation, Wilmslow, United Kingdom 4 Waters Corporation, Milan, Italy 5 Faculty of Life Sciences, University of Manchester, United Kingdom 6 Department of Neuroscience, University of Torino, Italy
P-698 RELATION BETWEEN CERVICAL CORD LESIONS AND DISK HERNIATION IN THE PA- TIENTS WITH MULTIPLE SCLEROSIS Amirhossein Sharirian1, Alireza Nikseresht2, Sadegh Izadi2, Pooria Ghadiri3, Nazila Hassanabadi3, Alireza Setarehaseman3 1 Student Research committee, Faculty Of Medicine, Jahrom University Of Medical Sciences, Jahrom, Iran 2 Department of Neurology ,Faculty of medicine, Shiraz university of Medical Sciences. 3 Department of Neurology Student Research committee Shiraz university of Medical Sciences
P-699 EPILEPSY IN THE PATIENT WITH MYASTHENIA GRAVIS, A CASE REPORT AND REVIEW OF THE LITERATURES Alireza Setarehaseman1, Maryam Sharifian1, Nazila Hassanabadi2, Abbas Mohammadi1, Pooria Ghadiri1, Amirhossein Sharifian3 1 Department of Neurology, Resident of neurology, Shiraz university of Medical Sciences 2 Department of Neurology Student Research committee Shiraz university of Medical Sciences 3 Department of Neurology, Faculty of medicine, Jahrom university of Medical Sciences
P-700 PLASMA LEVELS OF IL-17 AND IL-23 IN THE PATIENTS WITH MULTIPLE SCLEROSIS Abbas Mohammadi1, Gholam Ali Yousefipour2, Alireza setarehaseman1, Amirhossein sharifian3, Pooria Ghadiri1, Nazila Hassanabadi1, Maryam Sharifian4, 1 Department of Neurology Student Research committee, Shiraz university of Medical Sciences 2 Department of Neurology ,Faculty of medicine, Shiraz university of Medical Sciences. 3 Department of Neurology Student Research committee, Jahrom university of Medical Sciences 4 Department of Neurology, Resident of neurology, Shiraz university of Medical Sciences
229 P-701 ASSOCIATION OF PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR-GAMMA (PPAR T) ON PROGNOSIS OF MULTIPLE SCLEROSIS Abbas Mohammadi1, Abbas rahimi jaberi2, Golam hossein yousefipour2, Alireza Setarehaseman3, amirhossein sharifian4, maryam sharifian5, Pooria Ghadiri5, Nazila Hassanabadi5 1 Faculty of medicine, Student Research committee Shiraz university of Medical Sciences 2 Department of Neurology ,Faculty of medicine, Shiraz university of Medical Sciences. 3 Faculty of medicine, Student Research committee Shiraz university of Medical Sciences 4 Department of Neurology Student Research committee, Jahrom university of Medical Sciences 5 Department of Neurology, Resident of neurology, Shiraz university of Medical Sciences
P-702 THE MONTH OF BIRTH AND THE INCIDENCE OF MULTIPLE SCLEROSIS IN THE IRANIAN POPULATION Amirhossein Sharifian1, Maryam Sharifian2, Alireza Nikseresht3, Nazila hassanabadi4, alireza Setarehaseman4, abbas Mohammadi4, pooria Ghadiri4 1 Faculty Of Medicine, Jahrom University Of Medical Sciences, Jahrom, Iran 2 Department of Neurology, Resident of neurology, Shiraz university of Medical Sciences 3 Department of Neurology ,Faculty of medicine, Shiraz university of Medical Sciences. 4 Department of Neurology, Student Research committee Shiraz university of Medical Sciences
P-703 THE EFFECT OF FREE TESTOSTERONE ON COURSE, SEVERITY, DISEASE ACTIVITY AND DISABILITY IN MULTIPLE SCLEROSIS Nazila Hassanabadi1, Alireza Nikseresht2, Pooria Ghadiri3, maryam Sharifian4, amirhossein sharifian5, Abbas Mohammadi6, Alireza Setarehaseman7 1 Department of Neurology Student Research committee Shiraz university of Medical Sciences 2 Department of Neurology ,Faculty of medicine, Shiraz university of Medical Sciences. 3 Department of Neurology Student Research committee Shiraz university of Medical Sciences 4 Department of Neurology, Resident of neurology, Shiraz university of Medical Sciences 5 Department of Neurology Student Research committee, Jahrom university of Medical Sciences 6 Department of Neurology Student Research committee Shiraz university of Medical Sciences 7 Faculty of medicine, Student Research committee Shiraz university of Medical Sciences
P-704 NEUROBRUCELLOSIS IN A PATIENT WITH MULTIPLE SCLEROSIS; A CASE REPORT Pooria Ghadiri1, Nazila Hassanabadi1, Maryam Sharifian2, Alireza Nikseresht3, amirhossein sharifian4 1 Department of Neurology Student Research committee Shiraz university of Medical Sciences 2 Department of Neurology, Resident of neurology, Shiraz university of Medical Sciences 3 Department of Nephrology,Faculty Of Medicine, Shiraz university of Medical Sciences 4 Department of Neurology Student Research committee, Jahrom university of Medical Sciences
P-705 PLASMA PROTEIN MARKERS IN MAJOR DEPRESSIVE DISORDER TREATED WITH ANTIDEPRESSANTS Hye In Woo1, Jisook Park2, Jeong Soo Yang3, Shinn-Won Lim4, Min-Ji Kim4, Seonwoo Kim4, Doh Kwan Kim2, Soo-Youn Lee2 1 Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea 2 Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 3 Clinical Research Institute, Samsung Medical Center, Seoul, Korea 4 Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea
230 P-706 LOW-DOSE TOTAL BODY IRRADIATION IN NEONATAL MICE CAUSES LONG-TERM IMPAIRED COGNITIVE PERFORMANCE ASSOCIATED WITH CHANGES IN CREB / MIR-132-MEDIATED SYNAPTIC PLASTICITY Stefan J. Kempf1, Sonja Buratovic2, Christine von Toerne3, Marius Ueffing3, Simone Moertl1, Michael J. Atkinson1, 4, Per Eriksson2, Soile Tapio1 1 Institute of Radiation Biology, Helmholtz Zentrum München, German Research Center For Environmental Health, Neuherberg, Germany 2 Department of Environmental Toxicology, Uppsala University, Uppsala Sweden 3 Department of Protein Science, Proteomics Core Facility, Helmholtz Zentrum München, German 4 Research Center for Environmental Health, Neuherberg, Germany 5 Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
P-707 CLINICAL WORKFLOW FOR ANALYSIS OF HUMAN CSF PROTEINS USING HIGH RESOLUTION MASS SPECTROMETRY PARALLEL REACTION MONITORING MULTIPLEX ASSAYS Gunnar Brinkmalm1, Ann Brinkmalm1, Floor Duits2, Charlotte E. Teunissen2, Wiesje M. van der Flier2, Henrik Zetterberg1, Kaj Blennow1 1 University of Gothenburg, Mölndal, Sweden 2 VU University Medical Center, Amsterdam, The Netherlands
P-708 VALIDATION OF PROGNOSTIC BIOMARKERS FOR CONVERSION TO MULTIPLE SCLEROSIS IN PATIENTS WITH CLINICALLY ISOLATED SYNDROME Eva Borràs1, Ester Cantó2, Cristina Chiva1, Mar Tintoré2, Xavier Montalban2, Meena Choi3, Olga Vitek3, Manuel Comabella2 Eduard Sabidó1 1 Universitat Pompeu Fabra i Centre de Regulació Genòmica, Barcelona, Spain 2 Cemcat. Institut de Recerca Hospital Vall d’Hebrón, Barcelona, Spain 3 Purdue University, West Lafayette, Indiana, USA
P-709 STUDY OF THE EXPRESSION OF NUCLEOSIDE AND NUCLEOTIDE RECEPTORS IN MOUSE SPINAL CORD THROUGH MULTIPLE REACTION MONITORING. David Reigada1, Verónica Moral-Dardé2, Gemma Barroso2, Ana Gallardo-Aguilar2, Rosa Navarro-Ruíz1, Marcos Javier Caballero-López1, Ángela del Águila1, Teresa Muñoz-Galdeano1 Manuel Nieto-Díaz1 Rodrigo Martínez-Maza1 1 Molecular Neuroprotection Group. National Hospital for Paraplegics. 2 Proteomics Unit. National Hospital for Paraplegics.
P-710 IDENTIFICATION OF POTENTIAL BIOMARKERS OF ISCHEMIC STROKE BY INTEGRATING 2D-DIGE AND LABEL FREE-MS/MS Laura Mourino-Alvarez1, Felix Gil-Dones1, Alan Juarez-Belaunde2, Rafael Moreno-Luna1, Tamara Sastre-Oliva1, Carlos Marsal2, Luis R. Padial2, Juan Antonio López3 Maria G. Barderas1 1 Hospital Nacional De Parapléjicos, Toledo, Spain 2 Hospital Virgen de la Salud, Toledo, Spain 3 CNIC, Madrid, Spain
231 P-711 SEARCH FOR PERIPHERAL BIOMARKERS IN PATIENTS AFFECTED BY ACUTELY PSYCHOTIC BIPOLAR DISORDER: A PROTEOMIC APPROACH Federica Ciregia1, Laura Giusti1, Ylenia Da Valle1, Valentina Mantua2, Ginevra Orsolini3, Elena Donadio1, Gino Giannaccini1, Tiziana Ventroni1 Giovanni B. Cassano3 Antonio Lucacchini1 1 Department Of Pharmacy University Of Pisa 2 AIFA, Rome, Italy 3 Casa di Cura San Rossore, Pisa, Italy
P-712 COMPARATIVE PROTEOMIC ANALYSIS OF DIFFERENT FRAGILE X SYNDROME CELL LINES Valeria Marzano1, Stella Lanni2, Federica Palumbo2, Martina Goracci2, Giorgia Mancano2, Federica Iavarone1, Federica Vincenzoni1, Massimo Castagnola1 Pietro Chiurazzi2 Giovanni Neri2 Alberto Vitali3 Elisabetta Tabolacci 1 Institute Of Biochemistry And Clinical Biochemistry, Catholic University, Rome, Italy 2 Institute of Medical Genetics, Catholic University, Rome, Italy 3 Institute of Chemistry of Molecular Recognition, CNR, Rome, Italy
P-713 PROTEOMIC CHARACTERIZATION OF CLUSTER SPOTS DOWN REGULATED IN PARKINSON DISEASE. Rosa Lippolis3, Antonio Rosato1, Consiglia Pacelli2, Anna Ferretta2, Paola Tanzarella2, Tiziana Cocco2, Salbvatore Scacco2, Francesco Palmisano1 Damiana Calvano1 Sergio Papa2 1 Departartment of Chemistry, University of Bari Italy. 2 Department of Medical Basic Sciences, Neurosciences and Sense Organs University of Bari Italy. 3 Institute of Biomembranes and Bioenergetics, CNR, Bari, Italy.
P-714 DOWN REGULATION OF PLASMA APOLIPOPROTEIN A-IV IN SUICIDAL ATTEMPTERS: A MASS SPECTROMETRY BASED APPROACH Boby Mathew1, Krishnamachari Srinivasan2, Johnson Pradeep2, Amit Mandal1 1 St. John’s Research Institute, Bangalore 2 St. John’s Medical College, Bangalore
P-715 AMYLOID-INDUCED TAU PHOSPHORYLATION AT MOUSE NEURONAL SYNAPSES ANALYZED BY QUANTITATIVE PHOSPHOPROTEOMICS Hwan-Ching Tai1, BP-Chen Guo1, Yi-Ting Wang2, Bradley T. Hyman3, Yu-Ju Chen2 1 Department of Chemistry, National Taiwan University, Taipei, Taiwan 2 Institute of Chemistry, Academia Sinica, Taipei, Taiwan 3 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
P-716 CHARACTERIZING THE UNIQUE PROTEIN COMPLEXES FORMED BY PSD95 AND SAP102 IN THE POST-SYNAPTIC DENSITY OF THE BRAIN BY IP-LC-MS/MS Marcia Roy1, Thierry Le Bihan2, Fei Zhu1, Seth G. N. Grant1 1 Center for Clinical Brain Sciences and Center of Neuroregeneration, University of Edinburgh. 2 SynthSys Centre (Synthetic and Systems Biology Centre), University of Edinburgh
232 P-717 KRABBE DISEASE: FIRST INVESTIGATION AT THE PROTEOMIC LEVEL Claudia Landi1, Laura Bianchi1, Alice Luddi1, Assunta Gagliardi1, Alessandro Armini1, Paola Piomboni1, Luca Bini1, 1 University Of Siena
P-718 QUANTITATIVE MASS SPECTROMETRY BASED COMPARISON OF THE VENTRICULAR AND LUMBAR CEREBROSPINAL FLUID (CSF) PROTEOME Fabian Metzger1, Patrick Öckl, Carsten Korth, Markus Otto 1 Experimental Neurology/university Hospital Ulm 2 Department of neuropathology/university Hospital Düsseldorf
P-719 PPROD1 DOWNREGULATION: A MAJOR DEPRESSION BIOMARKER THAT REDUCES HIPPOCAMPAL NEUROPROTECTION THROUGH DECREASING AKT-NF¦ÊB PATHWAY ACTIVITY Peng Xie1 1 Institute Of Neuroscience, Chongqing Medical University, Chongqing, China
P-720 APPLICATION OF TRANSLATIONAL PROFILING METHOD FOR THE MOLECULAR CHARACTERIZATION OF LPS-STIMULATED BV2 MICROGLIA Hejer Boutej1, Jasna Kriz1 1 Research Center Of Mental Health’s University Institute Of Québec (CRIUSMQ), Laval University
P-722 A PROTEOMICS INVESTIGATION TO UNDERSTAND THE ROLE OF SUBVENTRICULAR ZONE IN THE SURVIVAL OF GLIOBLASTOMA PATIENTS Kishore Gollapalli1, Saicharan Ghantasala1, Sachendra Kumar1, Aliasgar Moiyadi2, Sanjeeva Srivastava1, 1 Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India 2 Department of Neurosurgery, Advanced Center for Treatment Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai, India
P-723 IDENTIFICATION OF ALTERED METABOLIC PROTEINS IN DISTINCT BRAIN REGIONS OF SCHIZOPHRENIA Ayesha Khan1, Saadia Zahid3, Michael Oellerich2, Abdul Asif2, Nikhat Ahmed1 1 University of Karachi, Karachi 75270, Pakistan 2 University Medical Center Goettingen, Goettingen, Germany 3 National University of Sciences and Technology, Islamabad, Pakistan
233 P-724 PHARMACO-PROTEOMIC ANALYSIS OF IPS-04001 IN ALZHEIMER’S DISEASE MOUSE MODEL In-Cheol Kang1 1 Hoseo University 2 InnoPharmaScreen Inc.
P-725 EXPLORATIVE CLINICAL PROTEOMICS IN NEURODEGENERATIVE DISORDERS Karl Hansson1, Mikko Hölttä1, Erik Portelius1, Henrik Zetterberg1, Kaj Blennow1, Johan Gobom1 1 Gothenburg University, Gothenburg, Västra Götaland, Sweden
P-726 THE PROTEOMIC LANDSCAPE OF THE SUPRACHIASMATIC NUCLEUS CLOCK REVEALS LARGE-SCALE COORDINATION OF KEY BIOLOGICAL PROCESSES Cheng-Kang Chiang1, Neel Mehta2, Peng Zhang2, Zhibin Ning1, Warren Y. L. Sun1, Hai-Ying M. Cheng2, Daniel Figeys1 1 Ottawa Institute Of Systems Biology And Department Of Biochemistry, Microbiology And Immunology, 2 Faculty Of Medicine, University Of Ottawa 3 Department of Biology, University of Toronto Mississauga
P-727 ANTIGEN AND PEPTIDE MICROARRAYS REVEAL AUTOANTIBODY TARGETS IN NARCOLEPSY Anna Häggmark1, Arash Zandian1, Björn Forsström1, Tomas Olsson2, Markku Partinen3, Mathias Uhlén1, Jochen Schwenk1, Peter Nilsson1 1 KTH - Royal Institute Of Technology, SciLifeLab, Stockholm, Sweden 2 Center for molecular medicine, Karolinska Hospital, Solna, Sweden 3 Helsinki Sleep Clinic, Helsinki, Finland
P-728 PHYSICAL EXERCISE MODULATES HIPPOCAMPAL PROTEIN EXPRESSION WITH NEUROPROTECTIVE EFFECTS IN SENESCENCE-ACCELERATED SAMP8 MOUSE MODEL. Marilisa Sulpizio1,2, Fabrizio Di Giuseppe1,2, Antonella Riviello1,2, Enrica Eleuterio1,2, Barbara Ghinassi3, Maria Angela D’Amico3, Angela Di Baldassarre3, Carmine Di Ilio1,2 Angelucci Stefania1,2 1 Department of Experimental and Clinical Sciences, “University G. d’Annunzio”, Chieti-Pescara,Aging 2 Research Center CeSI “University G. d’Annunzio” Foundation,CHIETI-66013, Via dei Vestini 31, Italy 3 Stem TeCh Group, CHIETI-66013,Via Polacchi,13, Italy 4 Department of Medicine and Aging Sciences, “University G. d’Annunzio”, CHIETI-66013, Via dei Vestini 31, Italy
P-729 EFFECT OF VITAMIN D ON MULTIPLE SCLEROSIS: NEUROCOGNITIVE IMPAIRMENT IMPLICATIONS Luis Cubano1, Karla Narvaez2, Maria Miranda2, Madeline Rodriguez1, Angel Chinea3, Nawal Boukli1 1 Universidad Central Del Caribe, Bayamon, PR 2 Interamerican University of Puerto Rico, Metropolitan Campus, San Juan, PR 3 San Juan MS Center, San Juan, PR
234 P-730 A CHEMICAL PROTEOIMCS FOR SEARCHING DIAGNOSTIC MARKERS OF PARKINSON FS DISEASE. Kazuki Misato1,2, Yohei Mukai1,2, Kazuma Higashisaka1,2, Yasuo Yoshioka1,2, Kazuya Nagano1,2, Haruhiko Kamada1,2,3, Yasushi Fujio1, Hideki Mochizuki4 Shin-ichi Tsunoda1,2,3 Yasuo Tsutsumi1,2,3 1 Graduate School Of Pharmaceutical Sciences , Osaka University, Osaka, Japan 2 National Institute of Biomedical Innovation, Osaka, Japan 3 MEI center, Osaka University, Osaka, Japan 4 Graduate School of Medicine, Osaka University, Osaka, Japan
P-731 STUDY ON THE TREATMENT MECHANISM OF VITAMIN D IN MS/EAE Shilian Liu1, Jifang Gao1 1 Department Of Biochemistry And Molecular Biology, School Of Medicine, Shandong Univeristy
P-732 QUANTITATIVE PROTEOMICS TO STUDY NEUROMUSCULAR DISORDERS Andreas Roos1,2, Laxmikanth Kollipara1, Stephan Buchkremer2, René Zahedi1 1 Leibniz-Institut Für Analytische Wissenschaften – ISAS – E.V., Dortmund, Germany 2 Institute of Neuropathology, University Hospital RWTH, Aachen, Germany
P-733 PROTEOMIC ANALYSIS OF THE FRONTAL CORTEX AND THE HIPPOCAMPUS MITOCHONDRIA IN THE ANIMAL MODELS OF DEPRESSION Aneta Stachowicz1, Katarzyna Gombik2, Maciej Suski1, Agnieszka Basta-Kaim2, Rafa Olszanecki1, Ryszard Korbut1 Jagiellonian University Medical College Polish Academy of Sciences
P-734 APPLYING MASS SPECTROMETRY-BASED QUALITATIVE PROTEOMICS TO HUMAN AMYGDALOID COMPLEX Enrique Santamaría1, Joaquin Fernandez-Irigoyen1, Maria Victoria Zelaya1 1 Navarrabiomed-Miguel Servet Foundation
P-735 QUANTITATIVE MASS SPECTROMETRY IDENTIFIES AGE-DEPENDENT CONTROL OF PROTEIN TRANSLATION BY FRAGILE X MENTAL RETARDATION PROTEIN Lujian Liao1, Xiaoyan Qin1, Chaoya Zheng1, Peter Vanderklish2, John Yates2 1 East China Normal University 2 The Scripps Research Institute
235 P-736 HIPPOCAMPAL PROTEIN CONCENTRATION GRADIENTS – THE KEY TO AUTOIMMUNITY IN ALZHEIMER’S DISEASE? Andreas Schroetter1, Fouzi El Magraoui1, Helmut Heinsen2, Thomas Mastalski1, Svenja Seger1, Martin Eisenacher1, Renata E. Leite3, Lea T. Grinberg4 Helmut E. Meyer5 1 Medizinisches Proteom-Center, Ruhr-Universitaet Bochum, Germany 2 Laboratory of Morphological Brain Research, Universitaet of Würzburg, Germany 3 University of Sao Paulo Medical School, Sao Paulo, Brazil 4 UCSF School of Medicin, Neurology, San Francisco, USA 5 Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. / Dortmund, Germany
P-737 CROSS-LINKED SITES MS ASSIGNMENT IN A PHOTOCHEMICAL INDUCED-COVALENT AB DIMER Marina Gay1, Mar Vilanova1, Montserrat Serra-Batiste2, Sílvia Vilaprinyó-Pascual2, Roberta Mazzucato2, Marta Vilaseca1, Natàlia Carulla2 1 Mass Spectrometry Core Facility, IRB Barcelona, Barcelona, Spain 2 IRB Barcelona, Barcelona, Spain
P-738 VITAMIN D BINDING PROTEIN ISOFORMS AND APOLIPOPROTEIN E IN CEREBROSPINAL FLUID AS EARLY PROGNOSTIC BIOMARKERS OF DISEASE AGGRESSIVENESS IN MULTIPLE SCLEROSIS Davide Corpillo1, Alessandra Giuliano Albo1, Simona Perga2, 3, Sara Falvo1, Raffaella Reviglione1, Marco Capobianco2, Antonio Bertolotto2, 3, 1 ABLE Biosciences - Bioindustry Park S. Fumero, Colleretto Giacosa, Turin, Italy 2 San Luigi University Hospital, Orbassano, Turin, Italy 3 Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy
P-739 THE HUMAN TORSIN A IN DROSOPHILA ACTIVATES THE UPR AND INCREASES SUSCEPTIBILITY TO OXIDATIVE STRESS Jong Bok Seo1, A-Young Kim2, Soo Young Kim1, Young Ho Koh2 1 Seoul Center, Korea Basic Science Institute 2 ILSONG Institute of Life Scienc, Hallym University
P-740 INVESTIGATING THE ROLE OF LG72 IN SCHIZOPHRENIA BY 2D-GEL ELECTROPHORESIS AND 15N METABOLIC LABELING Michaela Filiou1, Larysa Teplytska1, David Otte2, Andreas Zimmer2, Chris Turck1 1 Max Planck Institute Of Psychiatry, Munich, Germany 2 Institute of Molecular Psychiatry, Bonn, Germany
236 P-741 DETECTION AND QUANTIFICATION OF TAU PROTEOFORMS IN THE CSF OF ALZHEIMER’S DISEASE PATIENTS USING HIGH RESOLUTION TARGETED MASS SPECTROMETRY Nicolas Barthélemy1,2, Christophe Hirtz2, Audrey Gabelle2, François Fenaille1, Nicolas Sergeant3, Susanna Schraen-Maschke3, Christophe Junot1, Luc Buée3 François Becher1 Sylvain Lehmann2 1 CEA, iBiTec-S, Service de Pharmacologie et d’Immunoanalyse, Gif-sur-Yvette, France 2 CHU de Montpellier and Université Montpellier I, Laboratoire de Biochimie Protéomique Clinique, CMRR Montpellier, France. 3 CHU de Lille, Centre de Biologie Pathologie; Université Lille-Nord de France; INSERM U837; Lille, France
P-742 MS STRATEGY FOR IDENTIFICATION OF ALPHA-SYNUCLEIN PROTEOFORMS Melinda Rezeli1, Ákos Végvári1, Edina Silajdžic1, Maria Björkqvist1, Oskar Hansson2, György Marko-Varga1, Thomas Laurell1 1 Lund University, Lund, Sweden 2 University Hospital MAS, Malmö, Sweden
P-743 ORBITRAP PROTEOMICS ANALYSIS OF CSF TO IDENTIFY NOVEL MARKERS FOR PROGRESSION AFTER A FIRST ATTACK OF DEMYELINATION Marcel Stoop1, Tessel Runia1, Christoph Stingl1, Theo Luider1, Rogier Hintzen1 1 Erasmus University Medical Center
P-744 CHANGES IN THE HUMAN HIPPOCAMPAL PROTEOME DURING ALZHEIMER’S DISEASE David Hondius1,2, Pim van Nierop2, Ka Wan Li2, Jeroen Hoozemans1, Roel van der Schors2, Elise van Haastert1, Saskia van der Vies1, Annemieke Rozemuller1 August Smit2 1 Department of Pathology, VU University Medical Center 2 Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive 3Research, VU University Amsterdam, Neuroscience Campus Amsterdam, The Netherlands
P-745 ITRAQ-BASED QUANTITATIVE PROTEOMICS STUDY ON THE NEUROPROTECTIVE EFFECTS OF BUYANG HUANWU DECOCTION IN CEREBRAL ISCHEMIC STROKE MICE MODEL. Hong-Jhang Chen1, Yuh-Chiang Shen, Yet-Ran Chen1, Yun-Lian Lin1 1 National Research Institute Of Chinese Medicine, Ministry Of Health And Welfare, Taiwan 2 2Agricultural Biotechnology Research Center, Academia Sinica, Taiwan
P-746 PROTEOMICS OF SYNAPTOSOMAL FRACTIONS TO MAP PREFRONTAL CORTEX PROTEINS DURING ANHEDONIA Johan Palmfeldt1, Kim Henningsen2, Stine Aistrup2, Ove Wiborg2 1 Research Unit For Molecular Medicine, Aarhus University Hospital, Denmark 2 Centre for Psychiatric Research, Aarhus University Hospital, Denmark
237 P-747 BIOMARKER IDENTIFICATION IN ALZHEIMER´S DISEASE BRAIN TISSUE AND RELATIONSHIP TO GENETIC RISK FACTORS Francisco-Jose Fernandez Gomez1, Helene Obriot1, Sabiha Eddarkaoui1, Raphaelle Caillierez1, Vincent Deramecourt1, Malika Hamdane1, David Blum1, Luc Buée1 Valérie Buée-Scherrer1 Nicolas Sergeant1 1 Inserm U837, JPARC, Université Lille-Nord de France, UDSL, Lille, France
P-748 AN ION MOBILITY MASS SPECTROMETRY APPROACH TO ELUCIDATE THE MOLECULAR MECHANISMS UNDERLYING AGGREGATION IN NEURODEGENERATIVE DISEASES Fernando Benavente1, Laura Pont1, Estela Giménez1, Marta Vilaseca2, José Barbosa1, Victoria Sanz-Nebot1 1 Department of Analytical Chemistry. University of Barcelona. Diagonal 645, 08028 Barcelona, Spain. 2 Institute for Research in Biomedicine (IRB Barcelona). Baldiri Reixac 10, 08028 Barcelona, Spain.
P-749 VERIFICATION OF A PARKINSON’S DISEASE PROTEIN SIGNATURE IN T-LYMPHOCYTES BY MULTIPLE REACTION MONITORING Tiziana Alberio1, Kelly McMahon2, Manuela Cuccurullo3, Lee Gethings2, Craig Lawless4, Maurizio Zibetti5, Leonardo Lopiano5 Johannes Vissers2 Mauro Fasano1 1 University Of Insubria, Busto Arsizio, Italy 2 Waters Corporation, Manchester, UK 3 Waters Corporation, Milano, Italy 4 University of Manchester, Manchester, UK
238 19 - Technological horizons. MS imaging, targeted proteomics
P-750 SIMULTANEOUS PROTEIN DIGESTION AND 18O LABELING BY A GRAPHENE OXIDE BASED IMMOBILIZED ENZYMATIC REACTOR FOR HIGH THROUGHPUT QUANTITATIVE PROTEOME ANALYSIS Huiming Yuan1, Shen Zhang1, Lihua Zhang1, Yukui Zhang1 1 Dalian Institute Of Chemical Physics, Chinese Academy Of Sciences
P-751 SIMULTANEOUS PROTEIN DIGESTION AND 18O LABELING BY A GRAPHENE OXIDE BASED IMMOBILIZED ENZYMATIC REACTOR FOR HIGH THROUGHPUT QUANTITATIVE PROTEOME ANALYSIS Huiming Yuan1, Shen Zhang1, Lihua Zhang1, Yukui Zhang1 Dalian Institute Of Chemical Physics, Chinese Academy Of Sciences
P-752 IMMUNP-PROTEOMICS USING POLYCLONAL ANTIBODIES AND STABLE ISOTOPE LABELED AFFINITY-PURIFIED RECOMBINANT PROTEIN FRAGMENTS Fredrik Edfors1, Tove Boström1, Björn Forsström1, Mathias Uhlén1 1 Royal Institute of Technology, Division Of Proteomics And Nanobiotechnology
P-753 COMPOUND-CENTERED PROTEOMIC APPROACHES TO DEFINE THE PROTEIN TARGETS OF THE ANTITUMORAL NATURAL COMPOUND ORIDONIN. Fabrizio Dal Piaz1, Michele Vasaturo1, Roberta Cotugno1, Maria Antonietta Belisario1, Nunziatina De Tommasi1 1 Università Degli Studi Di Salerno
P-754 DEVELOPMENT OF ABSOLUTE QUANTIFICATION METHOD FOR DKK1 IN HUMAN SERUM USING LC-MS/MS Chihiro Ishikawa1, Kennichi Watanabe1, Tetsuya Nakagawa1, Masashi Yabuki1 Dainippon Sumitomo Pharma
P-755 HUMAN AORTIC VALVE STENOSIS ANALYZED BY MALDI-TOF IMAGING MASS SPEC- TROMETRY (MALDI-IMS) USING “LANGARTECH”, A CUSTOM MADE MATRIX SPRAYER. Ibon Iloro1, Amaia Bueno2, Laura Mourino-Alvarez3, Fernando de la Cuesta3, Fernando Vivanco4,5, Iraide Escobes1, Harkaitz Urreta2, Maria G. Barderas3 Felix Elortza1 1 Proteomics Platform, CIC bioGUNE, ProteoRed-ISCIII, CIBERehd, Science and Technology Park of Bizkaia, 48160, Derio, Spain. 2 IDEKO, Arriaga Industrialdea 2, Elgoibar, Gipuzkoa. 3 Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos (HNP), SESCAM, Toledo. 4 Department of Immunology, ISS- Fundacion Jimenez Diaz, Madrid. 5 Department of Biochemistry and Molecular Biology I, Universidad Complutense, Madrid.
239 P-756 REPRODUCIBLE PROTEIN SPOT COORDINATE DETECTION IN 2D-PAGE USING A PROTEIN MARKER GRID Simone König1, Marina Hanneken1, Doreen Ackermann1 1 University Of Münster
P-757 DETECTION OF BACTERIA AND COMPARATIVE PROTEOMIC ANALYSIS BY MASS SPECTROMETRY Byoung Chul Park1, Juyeon Ryu, Jeong-Hee Moon, Jeong Hoon Kim, Sung Goo Park 1 KRIBB
P-758 A PROTEIN BIOMARKERS PANEL TO DISCRIMINATE PROGRESSIVE FROM NON-PROGRESSIVE CHRONIC KIDNEY DISEASE USING A TARGETED PROTEOMICS METHOD Stéphanie Fraselle1, Koen De Cremer1, Wim Coucke1, Griet Glorieux2, Jill Vanmassenhove2, Eva Schepers2, Nathalie Neirynck2, Joris Van Loco1 Wim Van Biesen2 Raymond Vanholder2 1 Scientific Institute of Public Health, Brussels, Belgium 2 Ghent University Hospital, Ghent, Belgium
P-759 OPTIMIZATION OF THE MALDI IMAGING LASER REPETITION RATES USING AN ORTHOGONAL MALDI MASS SPECTROMETER Emmanuelle Claude1, Mark Towers1, James Langridge1 1 Waters Corporation, Wilmslow, UK
P-760 LIPID VISUALISATION AND IDENTIFICATION THROUGH COLLISION CROSS SECTION AIDED CORRELATION OF MALDI IMAGING AND MS/MS FRAGMENTATION DATA SETS Mark Towers1, Emmanuelle Claude1, Johannes Vissers1 1 Waters Corporation, WIlmslow, UK
P-761 EXPLORING IMPACT OF DYNAMIC ACCUMULATION FOR IMPROVING MS/MS QUALITY OF QQTOF DATA Joerg Dojahn1, Christie Hunter2, Sean Seymour2, Nick Bloomfield3 1 AB SCIEX, Darmstadt, Hessen, Germany 2 AB SCIEX, Foster City, CA, USA 3 2AB SCIEX, Redwood City, CA, USA
P-762 PRECISION AND NORMALIZATION STRATEGIES FOR LABEL FREE MRM ANALYSIS OF PLASMA PEPTIDES OVER AN 18 MONTH TIME COURSE STUDY Xiaomin Song1, Jemma Wu1, Ardeshir Amirkhani1, Thiri Zaw1, Dylan Xavier1, Mark P Molloy1 1 Australian Proteome Analysis Facility
240 P-763 RECONSTRUCTION OF HUMAN PROTEOME: REVIVAL OF TARGETED PROTEOMICS FROM SHOTGUN MASS SPECTROMETRY Arthur Kopylov1 1 Institute Of Biomedical Chemistry RAMS
P-764 DEVELOPMENT OF A WORKFLOW FOR THE DETECTION OF DRUG-DERIVED ADDUCTS ON PROTEINS Adelina E Acosta-Martin1,2, Paola Antinori-Malaspina1,3, Chakradhara RS Uppugunduri4,5, Youssef Daali6, Marc Ansari4,5,7, Denis F Hochstrasser1,2,3, Alexander Scherl1,2,3, Pierre Lescuyer1,2 Markus Müller8 1 Department of Human Protein Science, Faculty of Medicine, University of Geneva, Geneva, Switzerland 2 Department of Genetic and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland 3 Swiss Centre of Applied Human Toxicology, Geneva, Switzerland 4 OncP-Hematology Unit, Department of Pediatrics, Geneva University Hospital, Geneva, Switzerland 5 CANSEARCH Research Laboratory, Geneva Medical University, Geneva, Switzerland 6Division of Clinical Pharmacology & Toxicology, Geneva University Hospitals, Geneva, Switzerland 7 Charles-Bruneau Cancer Center, CHU Sainte-Justine Research Center, Montreal, QC, Canada 8 SIB-Swiss Institute of Bioinformatics, University of Geneva, Switzerland
P-765 EVALUATION AND PROTEOMICS APPLICATIONS OF NEUTRON-ENCODED TMT10-PLEXING Thilo Werner1, Gavain Sweetman1, Maria Fälth-Savitski1, Toby Mathieson1, Marcus Bantscheff1, Mikhail Savitski1 1 Cellzome GmbH • A GSK Company
P-766 MALDI-TOF/TOF-IMS ON FORMALIN FIXED PARAFFIN EMBEDDED (FFPE) HUMAN BRAINSTEM TISSUE; EXAMINATION OF PEPTIDE EXPRESSION IN THE ROSTRAL (OPEN) MEDULLA Nicholas Hunt1, 2, Leo Phillips3, Karen Waters1, 2, 4, Rita Machaalani1, 2, 4 1 Sydney Medical School, University Of Sydney, NSW, Australia 2 BOSCH Institute, University of Sydney, NSW, Australia 3 Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, NSW, Australia 4The Children’s Hospital, Westmead, NSW, Australia
P-767 PEPTIDE TISSUE IMAGING MASS SPECTROMETRY ON TISSUE MICRO ARRAYS FOR CANCER DIAGNOSTICS Peter Hoffmann1, Johan OR Gustafsson1, Parul Mitall1, James Eddes1, Manuela Klingler-Hoffmann1, Martin K. Oehler2 1 Adelaide Proteomics Centre, University Of Adelaide, Adelaide, South Australia, Australia 2 Robinson Institute, Research Centre for Reproductive Health, School of Paediatrics and Reproductive 3Health, University of Adelaide, Adelaide, South Australia, Australia
241 P-768 ELEVATING PROTEIN IDENTIFICATIONS PER MINUTE BY USING SPELC-MS/MS IN COMBINATION WITH ULTRA-SHORT GRADIENTS Nadine Binai1, 2, Fabio Marino1,2, Peter Sondergaard3, Nicolai Bache3, Shabaz Mohammed1,2,4, Albert Heck1,2 1 Utrecht University, Utrecht, The Netherlands 2 Netherlands proteomics center, Utrecht, The Netherlands 3 Thermo Fisher Scientific, Odense, Denmark 4 University of Oxford, Oxford, United Kingdom
P-769 IMPROVED ANALYSIS OF PHOSPHOLIPIDS USING GRAPHENE OXIDE AS A MATRIX FOR MALDI IMAGING MASS SPECTROMETRY Yan Cai1, Ying Zhang1, Jing Jiao1, Pengyuan Yang1, Haojie Lu1 1 Fudan University
P-770 SINGLE-TUBE SAMPLE PREPARATION WORKFLOWS USING PARA-MAGNETIC BEADS FOR ULTRA-SENSITIVE PROTEOMICS Jeroen Krijgsveld1, Christopher Hughes1 1 European Molecular Biology Laboratory (EMBL)
P-771 A NOVEL MULTIPLE REACTION MONITORING METHOD OF QUANTITATIVE PROTEOMICS BY USING COMBINATION OF MULTIPLEX LABELING AND QCONCAT. Yi Wang1, XiaoHui Liu1, Lei Zhang1, Haojie Lu1, pengyuan Yang1 1 Fudan University,shanghai,P.R.China
P-772 TUNABLE ISOELECTRIC FOCUSING VIA MOVING REACTION BOUNDARY FOR HIGH RESOLUTION TWP-DIMENSIONAL GEL ELECTROPHORESIS AND PROTEOMICS Chen-Gang Guo1, Si Li1, Guo-Qing Li1, Jian Yan1, Rong-Zhong Liu1, Ying Qing1, Jing-Li Hou1, Liu-Yin Fan1 Hua Xiao1 Cheng-Xi Cao1 1 Shanghai Jiao Tong University, Shanghai, 200240, China
P-773 INTEGRATING HEAT STABILIZION WITH MALDI IMAGING ENABLES MOLECULAR DISTRIBUTION IMAGES OF HIGH QUALITY TISSUE Mats Borén1, Anna Nilsson2, Richard Goodwin3, Per E. Andrén2 1 Denator, Arvid Wallgrens backe 20, 413 46 Gothenburg, Sweden 2 Uppsala University, Husargatan 3, 751 24 Uppsala, Sweden 3 AstraZeneca, Alderley Parc, SK10 4TF, Cheshire, UK
P-774 COMPREHENSIVE RELATIVE QUANTIFICATION OF THE CYTOCHROMES P450 USING SWATH(TM) ACQUISITION Rosalind Jenkins1, Sibylle Heidelberger2, Thomas Knapman2, Francesco Brancia2, Neil Kitteringham1, Kevin Park1 1 University Of Liverpool, Liverpool, Merseyside, UK 2 AB SCIEX, Warrington, Cheshire, UK
242 P-775 ULTRA-LOW FLOW ESI-MS FOR THE DETECTION OF POST TRANSLATIONAL MODIFICATION (PTM) SITES AND THE INCREASED SEQUENCE COVERAGE OF PROTEINS IN A SINGLE ANALYSIS Stephen Lock1 1 Ab Sciex
P-776 CAN MRM-BASED SECRETOME PROFILING BE USED AS DRUG EVALUATION ASSAY? Besnik Muqaku1, Andrea Bileck1, Dominique Kreutz1, Rupert Mayer1, Astrid Slany1, Christopher Gerner1 1 University Of Vienna - Institute Of Analytical Chemistry
P-777 EXTENDING PROTEOME COVERAGE THROUGH AN ON-LINE 2D SCX-RP ULTRA-HIGH PRESSURE SYSTEM Fabio Marino1, Nadine A. Binai1, Alba Cristobal1, Nicolai Bache2, Albert J.R. Heck1, Shabaz Mohammed3 1 Biomolecular Mass Spectrometry And Proteomics Group, Utrecht, The Netherlands 2 Thermo Fisher Scientific, Odense, Denmark 3 Chemistry Research Laboratory, Oxford, UK
P-778 TARGETED PROTEOMICS WITH A HIGH-PERFORMANCE TRIPLE QUADRUPOLE MASS SPECTROMETER AND NEXT GENERATION ESI SOURCE Robert Maxwell1, Stephen Zanon1, Maurizio Splendore1, Desmond Kaplan1, Karen Salomon1, Pierre-Olivier Schmit2 1 Bruker Daltonics CAM, Fremont, California/USA 2 Bruker Daltonics LSC, Wissembourg/France
P-779 QUANTIFYING CYTOCHROME P450 ENZYMES INVOLVED IN XENOBIOTIC METABOLISM – SCREENING OF DRUG-INDUCED PROTEIN EXPRESSION BY TXP-IMMUNOAFFINITY MASS SPECTROMETRY Frederik Weiss1, Bart van den Berg1, Hannes Planatscher1, Helen Hammer1, Thomas O Joos1, Oliver Poetz1 1 NMI
P-780 PNGASE F-CATALYZED 18P-LABELING FOR QUANTITATIVE GLYCOMICS AND GLYCOPROTEOMICS SIMULTANEOUSLY Weiqian Cao1, Wei Zhang1, Pengyuan Yang1 1 Fudan University
P-781 AN AUTOMATED DUAL-ONLINE MULTIFUNCTIONAL ULTRAHIGH PRESSURE LIQUID CHROMATOGRAPHY SYSTEM FOR HIGH THROUGHPUT AND EXTENSIVE PROTEOMICS ANALYSIS. Hangyeore Lee1, Sang-Won Lee1 1 Korea University
243 P-782 SRM VS HR-MS QUANTITATIVE PROTEOMICS; MATRIX EFFECT AND LOQ IN SERUM Dominique Baiwir1, Nicolas Smargiasso1, Gabriel Mazzucchelli1, Edwin De Pauw1 1 Laboratory of mass Spectrometry, GIGA-R, University Of Liege
P-783 AUTOMATED ISOFORM DETECTION BY CUSTOMIZED PEPTIDE IDENTIFICATION METHODS AND NOVEL HIGH THROUGHPUT LCMS INSTRUMENTATION Lasse G Falkenby1, Remco Swart2, Martin R Larsen1 1 University Of Southern Denmark, Odense, Denmark 2 Thermo Scientific, Germering, Germany
P-784 PROBING PROTEIN STRUCTURAL TRANSITIONS IN COMPLEX BIOLOGICAL BACKGROUNDS ON A LARGE SCALE Paola Picotti1, Yuehan Feng1, Giorgia De Franceschi1, Abdullah Kahraman1, Martin Soste1, Andre Melnik1, Paul Boersema1, Patrizia Polverino De Laureto2 1 ETH Zurich, Zurich, Switzerland 2 CRIBI Biotech. Centre, Univeristy of Padua, Padua, Italy
P-785 COMPARISON OF GROUP SPECIFIC IMMUNOAFFINITY MS BASED QUANTIFICATION OF PLASMA BIOMARKERS FROM DRIED BLOOD SPOTS, DRIED PLASMA SPOTS AND BLOOD PLASMA Christopher J. Pynn1, Benedikt Lang2, Bart H.J. van den Berg3, Christoph Haertel4, Wolfgang Goepel4, Martin Gamer5, Peter Schulz-Knappe5, Oliver Poetz2 Dieter Stoll1 1 Albstadt-Sigmaringen University of Applied Sciences, Sigmaringen, Germany 2 NMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany 3 University Hospital of Schleswig-Holstein, Pediatrics Department, Luebeck, Germany 4 Protagen AG, Dortmund, Germany
P-786 COMPARING ION THERMAL FOCUSING ELECTROSPRAY AND NANOSPRAY LC-MS/MS FOR CHARACTERIZING HUMAN EMBRYONIC STEM CELLS AND NEURAL PROGENITOR CELLS Raghothama Chaerkady1, Vadiraja B. Bhat2, Dawn Stickle2, Robert Giuffre2, Richard Blankley4, Hyesoo Kim1, Robert N Cole1, Candace L Kerr3 1 Johns Hopkins University School of Medicine, Baltimore, MD, USA 2 Agilent Technologies, Wilmington, DE, USA 3 University of Maryland, Baltimore, MD, USA 4 Agilent Technologies, Stockport,Cheshire, UK
P-787 MASS DEFECT-BASED PSEUDP-ISOBARIC DIMETHYL LABELING METHODS FOR PROTEOME QUANTIFICATION Yuan Zhou1, Lihua Zhang1, Yukui Zhang1 1 Dalian Institute Of Chemical Physics
244 P-788 ABSOLUTE QUANTIFICATION OF 26 CYTOCHROME P450 ENZYMES AND UDP- GLUCURONOSYLTRANSFERASES IN HUMAN LIVER MICROSOMES USING QCONCAT/ MRM APPROACH Aihua Sun1, Yali Lu2, Fuchu He3, Ying Jiang4 1 Beijing Proteome Research Center
P-789 EXPANSION OF ION LIBRARY FOR MINING SWATH DATA THROUGH FRACTIONATION PROTEOMICS Jin Zi1, Shenyan Zhang1, Ruo Zhou1, Baojin Zhou1, Shaohang Xu1, Fengji Tan1, Bo Wen1, Quanhui Wang1, 2 Liang Lin1 Siqi Liu1, 2 1 BGI-Shenzhen, Shenzhen, Guangdong, China 2 CAS Key Laboratory of Genome Sciences and Information, Beijing, China
P-790 USE OF MONOCLONAL ANTIBODY TO AID DIAGNOSIS AND PROGNOSTIC EVALUATION OF HEPATOCELLULAR CARCINOMA Liu Ying1, Liu Gang1, Junyi Jiang1, Chi Jian1 1 State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
P-791 DEVELOPMENT OF A “UNIVERSAL” MASS SPECTROMETRY METHOD BRINGS THE END OF TIME-CONSUMING DATA-DEPENDENT METHOD OPTIMIZATION FOR ACHIEVING MAXIMAL IDENTIFICATIONS FROM ANY SAMPLE TYPE Shannon Eliuk1, Philip Remes1, Nina Soltero1, Michael Senko1, Vlad Zabrouskov1 1 Thermo Fisher Scientific
P-792 SIMS AND MALDI IMAGING METHODOLOGIES REVEAL LIPID MARKERS OF CHONDROGENIC DIFFERENTIATION Beatriz Rocha1, Berta Cillero-Pastor2, Gert EijKel2, Anne Bruinen2, Cristina Ruiz-Romero1,3, Ron M. A. Heeren2, Francisco. J. Blanco1 1Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña 2 Biomolecular Imaging Mass Spectrometry (BIMS), FOM Institute AMOLF, Amsterdam, The Netherlands 3 CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain.
P-793 A RIBONUCLEIC ACID BASED STRATEGY FOR RNA-BINDING PROTEOME ANALYSIS Chao Fan1, Xiaojun Ren1, Weijie Qin1, Xiaohong Qian1 1 National Center For Protein Sciences Beijing, State Key Laboratory Of Proteomics, Beijing Proteome Research Center, Institute Of Radiation Medicine
245 P-794 DIRECT TISSUE ANALYSIS BY MALDI-MASS SPECTROMETRY IMAGING (MSI) REVEALS A MOLECULAR PATTERN OF ARTERIAL LAYERS IN ATHEROSCLEROSIS DEVELOPMENT Marta Martin-Lorenzo1, Benjamin Balluff2, Aroa Sanz-Maroto1, Ricardo Carreira2, Rene van Zeijl2, Laura Gonzalez-Calero1, Liam McDonnell2, Gloria Alvarez-Llamas1 Fernando Vivanco1, 3 1 IIS-Fundacion Jimenez Diaz 2 Leiden University Medical Center 3 Universidad Complutense de Madrid
P-79 IMPROVED IONIZATION EFFICIENCY USING ACETONITRILE AS A DOPANT TO NANP-ELECTROSPRAY FOR THE ANALYSIS OF CLINICAL SAMPLES Scarlet Beck1, Igor Paron1, Annette Michalski2, Stephanie Kaspar2, Markus Lubeck2, Carsten Baessmann2, Juergen Cox1, Matthias Mann1 1 Max Planck Institute of Biochemistry, Martinsried/Munich, Bavaria, Germany 2 Bruker Daltonics, Bremen, Niedersachsen, Germany
P-796 QUANTITATIVE EVALUATION OF GSTS IN MOUSE SERUM BY MRM Haidan Sun1, Weiqiao Rao2, Quanhui Wang1, Guixue Hou1, Yang Zhou1, Liang Lin2, Siqi Liu1, 1 Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China 2 Proteomics Division, BGI-Shenzhen, Shenzhen, Guangdong, China
P-797 INTERFACING SURFACE ACOUSTIC WAVE NEBULIZATION WITH LC-MS Karina Tveen Jensen1, Robert Wilson2, Frank Gesellchen2, Mohd Ismail2, Corinne Spickett1, Jonathan Cooper2, Andrew Pitt1, 1 Aston University, Birmingham, UK 2 Glasgow University, Glasgow, UK
P-798 DEVELOPMENT OF SELECTED REACTION MONITORING (SRM) ASSAYS FOR QUANTIFICATION OF ANGIOTENSIN-II SIGNATURE PROTEINS IN HUMAN URINE Ana Konvalinka1, Andrei Drabovich2, James Scholey1, Eleftherios Diamandis1, 2 1 Toronto General Hospital, University Health Network, University Of Toronto 2 Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
P-799 DEVELOPMENT OF A HIGH-THROUGHPUT BINDER SELECTION AND SCREENING PLATFORM Jonas Schaefer1, Andreas Plückthun 1 University of Zurich, Department of Biochemistry 2 University of Zurich, Department of Biochemistry
246 P-800 TARGETED ANALYSIS IN PRM MODE TOWARDS CLINICAL APPLICATION: OPTIMIZATION OF EXPERIMENTAL SETUP AND DATA PROCESSING FOR ACCURATE AMYLOID DIAGNOSIS Sophie Liuu1,2, Emmanuelle Demey-Thomas1,2, Emie Durighello1,2, Gilles Grateau3, Joëlle Vinh1,2 1 Spectrométrie De Masse Biologique Et Protéomique, ESPCI ParisTech, PSL Research University, Paris, France. 2 CNRS USR 3149, Paris, France. 3 Service de médecine interne, Hôpital Tenon, UPMC, INSERM U933, Paris, France.
P-801 LOCALIZING AND CHARACTERIZING DISULFIDE BONDS IN MS-BASED PROTEOMICS USING ONLINE LC–ELECTROCHEMISTRY–MS Linda Switzar1, Simone Nicolardi1, Hans Dalebout1, Annemieke Aartsma-Rus2, Magnus Palmblad1, Yuri van der Burgt1 1 Center for Proteomics and Metabolomics, Leiden University Medical Center (LUMC), Leiden, The Netherlands 2 Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands
P-802 EXPLORING THE EFFECT OF DMSO AS A MOBILE PHASE ADDITIVE FOR IMPROVING PROTEIN IDENTIFICATION AND SWATH ACQUISITION BY NANOLC/MS/MS Remco Van Soest1, Christie Hunter1, Jenny Albanese1, Mark Yang1 1 AB SCIEX
P-803 A NOVEL AND ROBUST WORKFLOW FOR PROTEIN QUANTITATION AND LARGE-SCALE BIOMARKER STUDY IN HUMAN PLASMA Xiaoqian Liu1, 2, Qin Fu1, 2, Michael Kowalski3, Graham Threadgill3, Christie Hunter4, Weihua Ji5, Joan Bathon6, Jennifer Van Eyk1, 2 1 Johns Hopkins University 2 Advanced Clinical Biosystems Institute, Cedars Sinai Medical System 3 Beckman Coulter 4 AB Sciex 5 National Institute of Standards and Technology 6 Columbia University College of Physicians and Surgeons
P-804 EVALUATION OF NEW KIDNEY INJURY BIOMARKERS USING ABSOLUTE QUANTITATIVE PROTEOMICS (PSAQ AND SRM) Benoit Gilquin1,2,3, Mathilde Louwagie1,2,3, Guillaume Picard4, Leila El Kholy1,2,3, Myriam Ferro1,2,3, Caroline Barau5, Michel Jaquinod1,2,3, Virginie Brun1,2,3 1 CEA, IRTSV, Biologie À Grande Echelle, F-38054 Grenoble, France 2 INSERM, U1038, F-38054 Grenoble, France 3 Université Grenoble-Alpes, F-38000 Grenoble, France 4 Promise Advanced Proteomics, F-38040 Grenoble, France 5 Plateforme de ressources biologiques, Groupe Hospitalier Henri Mondor, Créteil, F-94000, France
247 P-805 IMMOBILIZED MONOLITHIC ENZYMATIC REACTORS FOR ONLINE DIGESTION OF PROTEINS SECRETED BY DEVELOPING HUMAN EMBRYOS Wei-Qiang Chen1, Philipp Obermayr1, Urh Cernigoj2, Jana Vidic2, Miloš Barut2, Tanja Panic-Jankovic1, Mikhail Gorshkov3, Goran Mitulovic1 1 Medical University Of Vienna, Austria 2 BIA Separations, Ajdovšcina, Slovenia 3 Institute for Energy Problems of Chemical Physics, Moscow, Russia
P-806 EVALUATION OF DATA-INDEPENDENT ACQUISITION APPROACHES FOR SPIKED PEPTIDES IN HELA DIGEST ON Q-OT-QIT MASS SPECTROMETER Wei Zhang1, Reiko Kiyonami2, Zheng Jiang1, Wei Chen1 1 Thermo Fisher Scientific, Shanghai, China 2 Thermo Fisher Scientific, San Jose, CA, USA
P-807 BARCDB: A NEW RESEARCH TOOL FOR THE ANALYSIS OF BIOSPECIMENS Joakim Galli1, Johan Oelrich1, Mike J Taussig2, Ulrika Andreasson3, Eva Ortega-Paino3, Ulf Landegren1 1 Dept. of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 08 Uppsala, Sweden 2 Protein Technology Group, Babraham Bioscience Technologies Ltd., Babraham Research Campus, Cambridge CB22 3AT, UK 3 Department of Immunotechnology/Create Health, Lund University, Medicon Village, building 406, SE-223 81 Lund, Sweden
P-808 HIRIEF COUPLED WITH MS/MRM FOR ANTIBODY FREE PROTEIN QUANTIFICATION IN HUMAN PLASMA Davide Tamburro1, Rui Mamede-Branca1, Henrik Johansson1, Ann-Sofi Sandberg1, Maria Pernemalm1, Janne Lehtiö1 1 Karolinska Institute, Stockholm, Sweden
P-809 IELEMENT: NEW ULTRA-HIGH RESOLUTION MS (UHR-MS) UHRMS SIGNAL HANDLING APPROACH FOR MORE ACCURATE METABOLITE IDENTIFICATION Wei-Hung Chang1, Yu-Chen Huang1, Yet-Ran Chen1 1 Academia Sinica
P-810 MANIPULATION OF THE ISOTOPIC COMPOSITION OF PROTEINS AS A POWERFUL TOOL IN HIGH RESOLUTION HIGH SENSITIVITY MASS SPECTROMETRY ANALYSES Thibaut Léger1, Camille Garcia1, Joel Louette2, Jean-Michel Camadro1 1 Mass spectrometry Laboratory, Institut Jacques Monod, UMR 7592, Univ Paris Diderot, CNRS, 1 Sorbonne Paris Cité, F-75205 Paris, France 2 Cambridge Isotope Laboratories, Inc., Tewksbury, MA, USA
248 P-811 ABSOLUTE AND MULTIPLEX QUANTIFICATION OF THERAPEUTIC MONOCLONAL ANTIBODIES IN SERUM SAMPLES BY LC-SRM USING PSAQ STANDARDS. Dorothée Lebert 2, Guillaume Picard2, Clémence Arrivé1, Charlotte Beau-Larvor 3, Nicolas Mouz2, Christine Klinguer-Amour3, Virginie Brun1, Alain Beck3 Michel Jaquinod1 1 Exploring the Dynamics of Proteomes (EDyP), Laboratoire Biologie à Grande Echelle (BGE), U1038 IN- SERM/CEA/UJF, Institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV), CEA/Grenoble. 2 Promise Advanced Proteomics, 7 parvis Louis Néel - Batiment BHT 52A - CS 20050, 38040 Grenoble, France. 3 Centre Immunologie Pierre Fabre, 5 av Napoléon III, BP 497,74164 St Julien Genevois, France.
P-812 CHARACTERIZATION OF AN IMPROVED ULTRA-HIGH RESOLUTION QUADRUPOLE TIME OF FLIGHT (UHR-TOF) INSTRUMENT FOR PROTEOMICS APPLICATIONS Annette Michalski1, Markus Lubeck1, Stephanie Kaspar1, Oliver Raether1, Christoph Gebhardt1, Carsten Baessmann1 1 Bruker Daltonik GmbH
P-813 HIGH QUANTIFICATION EFFICIENCY IN PLASMA TARGETED PROTEOMICS WITH A FULL-CAPABILITY DISCOVERY Q-TOF PLATFORM Stephanie Kaspar1, Pierre-Olivier Schmit2, Carsten Baessmann1 1 Bruker Daltonik GmbH 2 Bruker Daltonique S.A.; Wissembourg, France
P-814 A COMPARISON OF LABEL FREE DDA-HRXIC AND DIA ACQUISITION ON A BENCHTOP UHR-Q-TOF Diego Bertaccini1, Marine Plumel1, Agnès Hovasse1, Alain Van Dorsselaer1, Christine Schaeffer-Reiss1 1 Cnrs-Iphc
P-815 A SISCAPA IMMUNP-MASS SPECTROMETRIC ASSAY FOR QUANTIFICATION OF SOLUBLE TRANSFERRIN RECEPTOR (STFR) IN HUMAN SERUM Oliver Drews1, N. Leigh Anderson2, Morteza Razavi3, Rainer Paape1, Waltraud Evers1, Detlev Suckau1 1 Bruker Daltonik GmbH, Bremen, Germany 2 SISCAPA Assay Technologies, USA 3 University of Victoria, Biochemistry Dept., Canada
P-816 NEW WORKFLOWS FOR IDENTIFICATION AND PROFILING OF DISULFIDE BONDS IN BIOPHARMACEUTICALS Carsten Baessmann1, Jan Wiesner1, Antje Kozicki1, Anja Resemann1, Rainer Paape1, Kristina Marx1, Lars Vorweg1, Andrea Kiehne1 Ralf Hartmer1 Detlev Suckau1 1 Bruker Daltonik GmbH, Bremen, Germany
249 P-817 THE PAN-HUMAN LIBRARY: A REPOSITORY OF ASSAYS TO QUANTIFY 10 000 PROTEINS BY SWATH-MS George Rosenberger1,2, Ching Chiek Koh1,3, Tiannan Guo1, Hannes L Röst1,2, Petri Kouvonen1, Ben C Collins1, Moritz Heusel1,6 Stephen Tate4 Ruedi Aebersold1,5 1 Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. 2 PhD Program in Systems Biology, University of Zurich and ETH Zurich, Zurich, Switzerland. 3 Ruprecht Karl University of Heidelberg, Heidelberg, Germany. 4 AB SCIEX, Concord, Ontario, Canada. 5 Faculty of Science, University of Zurich, Zurich, Switzerland.
P-818 ROBUSTNESS STUDY OF PEPTIDES IN PLASMA USING NOVEL TECHNOLOGIES IN AN LC-MS INSTRUMENT Karen Salomon1, Stuart Pengelley2, Zicheng Yang1, Maurizio Splendore1, Steven Schachterle1, 1 Bruker Corp, Fremont, CA USA 2 Bruker Corp, Bremen, Germany
P-819 INCREASE OF SENSITIVITY WITH THE NANP-ESI CAPTIVESPRAY SOURCE ASSOCIATED TO NANOBOOSTER (BRUKER) Marine Plumel1, Diego Bertaccini1, Agnes Hovasse1, Alain Van Dorsselaer1, Christine Schaeffer-Reiss1 IPHC CNRS University Of Strasbourg
P-820 ENRICHMENT OF CARBONYLATED PEPTIDES USING BIOTIN-LC (LONG CHAIN)-HY- DRAZIDE Jesper F. Havelund1,2, Katarzyna I. Wojdyla1, Ole N. Jensen1, Ian Max Møller2, Rogowska-Wrzesinska Adelina1 1 Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark 2 Department of Molecular Biology and Genetics, Aarhus University, Forsøgsvej 1, DK-4200 Slagelse, Denmark
P-821 IMPROVED SPATIAL RESOLUTION IN THE ANALYSIS OF FFPE TISSUE AFTER TRYPTIC DIGESTION Pierre-Olivier Schmit1, Janine Beckmann2, Nannan Tao3, Janina Oetjen4, Detlev Suckau2, Theodore Alexandrov5, Michael Becker2 1 Bruker Daltonique S.A., Wissembourg, France 2 Bruker Daltonik GmbH, Bremen, Germany 3 Bruker Daltonics inc, Fremont, California, USA 4 MALDI imaging lab, UNiversity of Bremen, Bremen, Germany 5 Center for industrial mathematics, Bremen, Germany
P-822.00 LC-MS/SRM ASSAY FOR THE QUANTIFICATION OF PROTEINS INVOLVED IN CELLULAR LIFE AND DEATH PROCESSES – ELUCIDATING THE UNDERLYING MECHANISMS OF MITOCHONDRIAL DYSFUNCTION Rune I.D. Birkler1, Zahra Nochi1, Johan Palmfeldt1, Niels Gregersen1 1 Research Unit For Molecular Medicine
250 P-823 COMPARISON OF THREE MS2 BASED QUANTITATIVE METHODS FOR TARGETED PEPTIDE QUANTITATION Jing Li1, Peiming Gu1, Zheng Jiang1, Wei Chen1 1 Thermo Fisher Scientific,Shanghai China
P-824 IMPROVEMENT OF SELECTIVITY AND SENSITIVITY BY OPTIMIZED SWATH METHODS Aline R Dörrbaum1,2, Zuzana Demianova1, Dea Slade3, Karl Mechtler1,4 1 Research Institute Of Molecular Pathology – IMP, Dr. Bohr-Gasse 7, A-1030 Vienna, Vienna, Austria 2 Hochschule Fresenius - University of Applied Sciences, Limburger Staße 2, Idstein, Hessen, Germany 3 Max F. Perutz Laboratories - MFPL, Dr. Bohr-Gasse 9, A-1030 Vienna, Vienna, Austria 4 Institute for Molecular Biotechnology of the Austrian Academy of Sciences - IMBA, Dr. Bohr-Gasse 3, A-1030 Vienna, Vienna, Austria
P-825 ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS IN HUMAN TRANSTHYRETIN ASSOCIATED WITH FAMILIAL AMYLOIDOTIC POLYNEUROPATHY BY TARGETED LC/MS AND INTACT PROTEIN MS Marta Vilà-Rico1, Núria Colomé-Calls2, Gonçalo Da costa3, Carlos Cordeiro3, Eduardo Barroso4, Antoni Planas1, Stephanie Kaspar5, Pierre-Olivier Schmit6 Carsten Baessmann5 Francesc Canals2 1 Institut Químic De Sarrià, Universitat Ramon Llull, Barcelona, Spain 2 Vall d’Hebron Institut of Oncology (VHIO) Vall d’Hebron University Hospital, Barcelona, Spain 3 Faculdade de Ciências de Universidade de Lisboa, Portugal 4 Unidade de Transplantaçao, Hospital Curry Cabral, Lisboa, Portugal 5 Bruker Daltonics, Bremen, Germany 6 Bruker Daltonique, S.A., Wissembourg, France
P-826 MOTIF-TARGETING PHOSPHOPEPTIDE ENRICHMENT FOR QUANTITATIVE PHOSPHOPROTEOME ANALYSIS Shunsuke Takagi1, Tatsuya Yazaki1, Kosuke Ogata1, Masaki Wakabayashi1, Naoyuki Sugiyama1, Yasushi Ishihama1 1 Graduate School of Pharmaceutical Sciences, Kyoto University
P-827 IN VIVO DEEP PROTEOME MICRO/NANP-HARVESTING EXPLORING INACCESSIBLE HUMAN TERRITORIES Ali Bouamrani1, Affif Zaccaria2, Adrien Mombrun1, Celine Le Clec’h1, Matthieu Dreyfus1, Frederic Dumas Bouchiat3, Nora Dempsey3, Francois Berger1 1 CEA LETI - Clinatec 2 NeuroProteomics Department - CMU Geneva 3 CNRS Louis NEEL
P-828 HIGHLY-MULTIPLEXED PROTEIN QUANTIFICATION FROM DRIED BLOOD SPOTS Andrew Chambers1, Andrew Percy1, Juncong Yang1, Christoph Borchers1 1 UVic Genome BC Proteomics Centre
251 P-829 COMPARISON OF DRUG DISTRIBUTIONS IN IN-VIVO ANIMAL AND IN-VITRO EXPERIMENTAL MODELS BY MALDI-MS IMAGING James J. Connell1, Yutaka Sugihara1, Thomas E. Fehniger1, György Marko-Varga1, Ákos Végvári1 1 Lund University, Lund, Sweden
P-830 DISTRIBUTION OF VEMURAFENIB IN MALIGNANT MELANOMA TISSUE BY MALDI MASS SPECTROMETRY IMAGING Yutaka Sugihara1, Ákos Végvári1, Charlotte Welinder1, Thomas E Fehniger1, György Marko-Varga1
252 20 - Proteomics of neglected tropical diseases
P-831 A SYSTEMS BIOLOGY APPROACH TO THE CHARACTERIZATION OF STRESS RESPONSE IN DERMACENTOR RETICULATUS TICK UNFED LARVAE. Lourdes Mateos-Hernández1, Margarita Villar1, Nieves Ayllón1, Isabel G. Fernández de Mera1, Ruth C. Galindo2, Marina Manrique3, Raquel Tobes3, José de la Fuente1,2 1 SaBio (Sanidad Y Biotecnología) Research Group. Instituto De Investigación En Recursos Cinegéticos, 2 IREC (CSIC-UCLM-JCCM). Ronda de Toledo s/n, 13005 Ciudad Real, Spain. 3 Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State 4Univer- sity, Stillwater, OK 74078, USA. 5Oh no sequences! Research group, Era7 Bioinformatics, Granada, Spain
P-832 PROTEOMICS DISCOVERY OF PLASMA TEST-OF-CURE MARKERS FOR TRYPANOSOMA BRUCEI GAMBIENSE HUMAN AFRICAN TRYPANOSOMIASIS Natalia Tiberti1, Floriane Pailleux1, Veerle Lejon2, Vanessa Lapierre1, Dieudonné Mumba Ngoyi3, Jospeh Mathu Ndung’u4, Alexandre Hainard1, Philippe Büscher5 Jean-Charles Sanchez1 1 University Of Geneva, Geneva, Switzerland 2 Institut de Recherche pour le Développement Unité Mixte de Recherche, Montpellier, France 3 Institut National de Recherche Biomédicale, Kinshasa, D. R. Congo 4 Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland 5 Institute of Tropical Medicine, Antwerp, Belgium
P-833 INCREASED ACUTE IMMUNE RESPONSE DURING THE MENINGP-ENCEPHALITIC STAGE OF TRYPANOSOMA BRUCEI RHODESIENSE SLEEPING SICKNESS COMPARED TO T. B. GAMBIENSE Natalia Tiberti1, Veerle Lejon2, Dieudonnée Mumba Ngoyi3, Enock Matovu4, John Enyaru4, Krister Kristensson5, Sylvie Bisser6, Joseph Mathu Ndung’u7 Philippe Büscher8 Jean-Charles Sanchez1 1 University Of Geneva, Geneva, Switzerland 2 Institut de Recherche pour le Développement Unité Mixte de Recherche, Montpellier, France 3 Institut National de Recherche Biomédicale, Kinshasa, D. R. Congo 4 Makerere University, Kampala, Uganda 5 Karolinska Institute, Stockholm, Sweden 6 University of Limoges, Limoges, France 7 Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland 8 Institute of Tropical Medicine, Antwerp, Belgium
P-834 STRUCTURAL CHARACTERIZATION OF ECHINOCOCCUS GRANULOSUS IMMUNODOMINANT PROTEINS AND DEVELOPMENT OF A NOVEL IMMUNOASSAY FOR HUMAN CYSTIC ECHINOCOCCOSIS Daniela Pagnozzi1, Grazia Biosa1, Anna Maria Roggio1, Vittorio Tedde1, Giovanna Masala2, Mara Mariconti3, Valeria Meroni3, Enrico Brunetti3 Maria Filippa Addis1 Sergio Uzzau1 1 Porto Conte Ricerche, Alghero, Italy 2 Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy 3 IRCCS - Policlinico San Matteo, Pavia, Italy
253 P-835 SCHISTOSOMIASIS INDUCES SIGNIFICANT CHANGES IN THE HOST BILE PROTEOME PROFILE. Eduardo de la Torre-Escudero1, Verónica Díaz1, Raúl Manzano-Román1, Ricardo Pérez-Sánchez1, Ana Oleaga1 1 Irnasa, Csic
P-836 SCHISTOSOMIASIS: WORM-INDUCED CHANGES IN THE PROTEOME OF THE LUNG ENDOTHELIAL CELL SURFACE Eduardo de la Torre-Escudero1, Verónica Díaz Martín1, Raúl Manzano-Román1, Ricardo Pérez-Sánchez1, Ana Oleaga1 1 Irnasa, Csic
P-837 SHOTGUN ANALYSIS OF PLATELETS FROM DENGUE PATIENS: CONTRIBUTIONS TO THE PATHOGENESIS ELUCIDATION Monique Trugilho1, Eugenio Hotzz2, Giselle Brunoro1, Paulo Carvalho3, Ana Gisele Neves-Ferreira1, Patricia Bozza1, Fernando Bozza2, Jonas Perales1 1 FIOCRUZ/Oswaldo Cruz Institute 2 FIOCRUZ/Evandro Chagas Clinical Research Institute 3 FIOCRUZ/Carlos Chagas Institute
254 21 - Interactomics and beyond. Protein networks and pathways
P-838 IMMUNP-COMPETITIVE CAPTURE MASS SPECTROMETRY FOR THE CHARACTERIZATION OF THE NS5A PROTEIN INTERACTOME IN A CELLULAR MODEL OF HEPATITIS C VIRUS REPLICATION Hélène Meistermann1, Junjun Gao1, Sabrina Golling1, Jens Lamerz1, Sophie Le Pogam1, Manuel Tzouros1, Lore Gruenbaum1, Hanno Langen1 Klaus Klumpp1 Angélique Augustin1 1F. Hoffmann-La Roche Ltd
P-839 ESSENTIAL AND NONREDUNDANT ROLES FOR DIAPHANOUS FORMINS IN CORTICAL MICROTUBULE CAPTURE AND DIRECTED CELL MIGRATION. Pascale Daou1, Salma Hasan1, Dennis Breitsprecher2, Emilie Baudelet1, Luc Camoin1, Stephane Audebert1, Bruce L Goode2, Ali Badache1 1 Inserm, U1068, CNRS, UMR7258, CRCM, Aix-Marseille Univ, UM 105, Institut Paoli-Calmettes, 2 Marseille Protéomique, Marseille, F-13009, France. 3 Department of Biology, Brandeis University, Waltham, MA 02454
P-840 STANDARD PROTEASOME AND IMMUNOPROTEASOME ASSOCIATE TO PREFERRED REGULATORS AS REVEALED BY LABEL-FREE QUANTITATIVE PROTEIN CORRELATION PROFILING Fabre Bertrand1, Thomas Lambour1, Luc Garrigues1, François Amalric1, Bernard Monsarrat1, Odile Burlet-Schiltz1, Marie-Pierre Bousquet-Dubouch1, 1 Ipbs - Cnrs
P-841 PROTEIN INTERACTOMICS BASED ON DIRECT MOLECULAR FISHING ON PARAMAGNETIC PARTICLES: PRACTICAL REALIZATION AND FURTHER SPR VALIDATION Alexis Ivanov1 1 Institute Of Biomedical Chemistry RAMS
P-842 MINIATURIZED CHEMOPROTEOMICS WORKFLOW ENABLES CHARACTERIZATION OF PATIENT SAMPLES H. Christian Eberl1, Stephanie Melchert1, Juergen Stuhlfauth1, Michael Steidel1, Marcus Bantscheff1 1 Cellzome GmbH, A GSK Company, Heidelberg, Germany
P-843 CHARACTERISATION OF B-CATENIN CONTAINING PROTEIN COMPLEXES BY INTRACELLULAR CP-IMMUNOPRECIPITATION AND HIGH OUTPUT WESTERN BLOTTING. Ragna Haeussler1, Bjoern Traenkle2, Fridolin Treindl1,2, Markus Templin1,2, Ulrich Rothbauer1,2 1 Natural and Medical Institute at the University of Tuebingen, Reutlingen, Germany 2 Pharmaceutical Biotechnology, Eberhard-Karls University Tuebingen, Germany
255 P-844 PROFILING OF CELLULAR SIGNAL TRANSDUCTION PATHWAYS USING A BEAD-BASED WESTERN BLOT Yvonne Heubach1, Fridolin Treindl1, 2, Johanna Naskou1, 3, Ewa Breitinger2, Hans Neubauer3, Tanja Fehm3, Markus F. Templin1, 2, 1 University of Tübingen, Tübingen, Germany 2 Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany 3 Heinrich Heine University of Duesseldorf, Duesseldorf, Germany
P-845 TARGETING CANCER RELEVANT SUBCELLULAR SPECIES OF B-CATENIN IN LIVING CELLS WITH NEW INTRACELLULAR FUNCTIONAL ANTIBODIES Felix Emele1, Björn Traenkle1, Oliver Poetz2, Bart van den Berg2, Kourosh Zolghadr3, Ulrich Rothbauer1,2 1 Pharmaceutical Biotechnology, Eberhard-Karls University Tuebingen, Germany 2 Natural and Medical Institute at the University of Tuebingen, Reutlingen, Germany 3 ChromoTek GmbH, Planegg-Martinsried, Germany
P-846 A COMPREHENSIVE PROTEOMICS SCREEN FOR SUBSTRATES OF THE SCFB-TRCP2 UBIQUITIN LIGASE Teck Yew Low1,2, Mao Peng1,2, Roberto Magliozzi3, Bas Breukelen1,2, Daniele Guardavacarro3, Albert J.R. Heck1,2 1 Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht 2 University, Padualaan 8, 3584 CH Utrecht, The Netherlands 2 Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands 3 Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
P-847 PROTEOME-WIDE ANALYSIS FOR IDENTIFICATION OF FUNCTIONAL SNPS Manuel Lehm1,2, Matthias Prestel1, Thanatip Viturawong2, Martin Dichgans1, Matthias Mann2 1 Institute for Stroke and Dementia Research, Munich, Germany 2 Max-Planck-Institute of Biochemistry, Martinsried, Germany
P-848 FUNCTIONAL INTERACTOMICS IN ALZHEIMER’S DISEASE Beena Hasan1, Nikhat Siddiqui1, Abid Azhar2, Abdul Asif3 1 Department Of Biochemistry, University Of Karachi, Karachi, Pakistan, 75270 2 Dr AQ Khan Institute of Biotechnology and genetic Engineering (KIBGE), University Of Karachi, Karachi, Pakistan, 75270 3 Department of Clinical Chemistry, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany
P-849 DICER2-ARGONAUTE2-R2D2 NETWORK DYNAMICS DURING ANTIVIRAL RESPONSE IN D. MELANOGASTER CELLS. Yann Verdier1, Karim Majzoub2, Iman Haddad1, Jules Hoffmann2, Jean-Luc Imler2, Joelle Vinh1 1 ESPCi ParisTech 2 CNRS UPR 9022
256 P-850 REVEALING DJ-1 FUNCTION UNDER OXIDATIVE STRESS THROUGH ITS INTERACTORS: IMPLICATIONS FOR PARKINSON’S DISEASE Sandra Anjo1,2, Vera M Mendes3, Mário Grãos3, Bruno Manadas1,3 1 CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal 2 Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal 3 Biocant - Biotechnology Innovation Center, Cantanhede, Portugal
P-851 A CROSS-OMICS GLOBAL PHOSPHOPROTEOMICS AND METABOLOMICS ANALYSIS REVEALS A CONNECTION BETWEEN KINASE INHIBITION AND RNA PROCESSING IN BCR-ABL POSITIVE MYELOMA CELLS Susanne Breitkopf1, Min Yuan1, Katja Helenius2, Costas Lyssiotis3, John Asara1 1 Beth Israel Deaconess Medical Center 2 Massachusetts Institute of Technology 3 Weill Cornell Medical College
P-852 ANDSYSTEM: AUTOMATED LITERATURE MINING AND INTERACTOME NETWORKS RECONSTRUCTION IN THE AREA OF BIOLOGY Vladimir Ivanisenko1, 2, Olga Saik1, 2, Evgeny Tiys1, Timofey Ivanisenko1, 2, Pavel Demenkov1, 2, Nikolay Kolchanov1 1 Institute Of Cytology And Genetics SB RAS 2 PBSoft LLC, Novosibirsk, Russia
P-853 MITOCHONDRIAL PROTEIN-PROTEIN INTERACTIONS REVEAL DIVERSE COMPLEXES AND DISEASE-RELEVANT FUNCTIONAL RELATIONSHIPS Ke Jin1,2, Vishaldeep Sidhu1, Matthew Jessulat1, James Vlasblom1, Viktor Deineko1, Sadhna Phanse1, Zhaolei Zhang2, Mohan Babu1 1 Department of Biochemistry, Research and Innovation Centre, University of Regina, SK, Canada 2 Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, ON, Canada
P-854 VIROTRAP: ABDUCTING PROTEIN COMPLEXES FROM MAMMALIAN CELLS Sven Eyckerman1, Kevin Titeca1, Emmy Vanquickelberghe1, Noortje Samyn1, Annick Verhee1, Delphine De Sutter1, Evy Timmerman1, Jan Tavernier1 Kris Gevaert1 VIB-UGent Medical Protein Research
P-855 TOWARDS MORE COMPREHENSIVE MODELING OF FUNCTIONAL REGULATION AND PATHWAY ENRICHMENT Ufuk Kirik1, Paolo Cifani1,2, Peter James1 1 Lund University, Lund, Sweden 2 Memorial Sloan Kettering Cancer Center, New York , USA
257 P-856 TOWARDS COMPREHENSIVE IDENTIFICATION OF PROTEIN-SPECIFIC INTERACTOMES VIA COMBINED USE OF AFFINITY MATRICES Kenneth Oh1, Matt Hammond1, Jonathan Kohn1, Anton Posch2, Nancy Braun2, Dalia Shezifi3, Galina Fihman3 1 BiP-Rad Laboratories, Hercules, California USA 2 BiP-Rad Laboratories, Munich, Germany 3 BiP-Rad Laboratories, Haifa, Israel
P-857 PATHOPHYSIOLOGICAL MECHANISMS IN COLLAGEN VI MYOPATHIES: CONTRIBUTION OF PROTEOMICS Sara De Palma1,2, Daniele Capitanio1,7, Michele Vasso2, Paola Braghetta3, Chiara Scotton4, Paolo Bonaldo3, Hanns Lochmüller5, Francesco Muntoni6 Alessandra Ferlini4 Cecilia Gelfi1,2,7 1 Department of Biomedical Sciences For Health, University of Milan, Segrate, Milan, Italy. 2 Institute of Bioimaging and Molecular Physiology, National Research Council, Segrate, Milan, Italy. 3 Department of Molecular Medicine, University of Padova, Padova, Italy 4 Department of Medical Sciences, University of Ferrara, Ferrara, Italy 5 Institute of Genetic Medicine, Newcastle University, Centre For Neuromuscular Diseases, Newcastle Upon Tyne, UK. 6 Dubowitz Neuromuscular Centre, University College London, Institute of Child Health, London, UK. 7 IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
P-858 INVESTIGATION OF MOLECULAR MECHANISMS IMPAIRED IN WILSON Maria Monti1, Diana Canetti1, Giancarlo Chesi2, Mafalda Concilli2, Roman Polishchuk2, Piero Pucci1 1 Department of Chemical Sciences and Interuniversity Consortium of Structural and Systems Biology (I.N.B.B.), Italy 2 Telethon Institute of Genetics and Medicine, Naples, Italy
P-859 OFD1 PARTICIPATE TO PRE-INITIATION COMPLEX AT THE CENTROSOME Flora Cozzolino1, Daniela Iaconis2, Maria Monti1,3, Brunella Franco2,4, Pucci Piero1,3 1 CEINGE Biotecnologie Avanzate S.C.A.R.L., Naples, Italy 2 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy 3 Department of Chemical Sciences, University of Naples Federico II, Italy 4 Department of Medical Translational Sciences, University of Naples “Federico II”, Italy
258 22 - Computational proteomics. Data analysis and biostatistics
P-860 GLYCOPEPTIDEID: WEB TOOL FOR N-GLYCOPEPTIDE IDENTIFICATION WITH CID MS2 SPECTRA Hannu Peltoniemi1, Sakari Joenväärä2, Hilkka Kontro2, Mayank Saraswat2, Risto Renkonen2 1 Applied Numerics Ltd, Helsinki, Finland 2 University of Helsinki, Helsinki, Finland
P-861 A CURRENT PERSPECTIVE ON USING R AND BIOCONDUCTOR FOR PROTEOMICS DATA ANALYSIS Sebastian Gibb1,3, Lisa Breckels2,3, Thomas Lin Pedersen4, Vladislav Petyuk5, Kathryn Lilley2, Laurent Gatto2,3 1 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany 2 Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, UK 3 Computational Proteomics Unit, Department of Biochemistry, University of Cambridge, UK 4 Chr. Hansen A/S, Hørsholm, Denmark / Technical University of Denmark, Kgs. Lyngby, Denmark 5 Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
P-862 A STATE-OF-THE-ART MACHINE LEARNING PIPELINE FOR THE ANALYSIS OF ORGANELLE PROTEOMICS DATA Laurent Gatto1,2, Lisa Breckels1,2, Samuel Wieczorek3, Thomas Burger3, Kathryn Lilley2 1 Computational Proteomics Unit, Department of Biochemistry, University of Cambridge, Cambridge, UK 2 Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK 3 Universite Grenoble-Alpes, CEA (iRSTV/BGE), INSERM (U1038), CNRS (FR3425), 38054 Grenoble, France
P-863 ANALYSIS OF LABELED AND NON-LABELED DIA AND DDA PROTEOMIC DATA USING ‘PROGENESIS QI FOR PROTEOMICS’ Lee Gethings1, Johannes Vissers1, Robert Tonge1, James Langridge1, Jackson Pope2 1 Waters Corporation, WIlmslow, UK 2 Nonlinear Dynamics, Newcastle upon Tyne, UK
P-864 A SITE FOR DIRECT PROTEIN-PROTEIN INTERACTION FROM STRUCTURAL MODELLING AND DOCKING FOR INTEGRIN AVB6 AND UPAR Gopichandran Sowmya1, Shoba Ranganathan1 1 Macquarie University, Sydney, NSW, Australia
259 P-865 UNLOCKING THE PUZZLING BIOLOGY OF THE BLACK PÉRIGORD TRUFFLE TUBER MELANOSPORUM Mohammad Islam1, Abidali Mohamedali1, Gagan Garg1, Javed Khan1, Alain-Dominque Gorse2, Jeremy Parsons2, Peter Marshall3, Shoba Ranganathan1 Mark Baker1 1 Macquarie University, Sydney, NSW, Australia 2 QFAB, The University of Queensland, St. Lucia, QLD, Australia 3 Terra Preta Truffles, Reisdale, NSW, Australia
P-866 NON-REDUNDANT PEPTIDES DATABASE FOR CHR18 ENCODED PROTEINS QUANTIFICATION Ekaterina Ilgisonis1 1Institute Of Biomedical Chemistry RAMS
P-867 CONSOLIDATING CHR 18 DATA USING KNOWLEDGEBASE OF PROTEIN AND TRANSCRIPT ANNOTATIONS Andrey Lisitsa1 1 Institute Of Biomedical Chemistry RAMS
P-868 CONSTRUCT: THREE-DIMENSIONAL VISUALIZATION OF SEQUENCE CONSERVATION Tessa Vermeire1, Stijn Vermaere1, Bert Schepens1, Xavier Saelens1, Lennart Martens1, Elien Vandermarliere1 1 VIB-UGent, Gent, Oost-Vlaanderen, Belgium
P-869 PEPSHELL: VISUALIZING CONFORMATIONAL PROTEOMICS. Elien Vandermarliere1, Davy Maddelein1, Niels Hulstaert1, Elisabeth Stes1, Kris Gevaert1, Edgar Jacoby2, Dirk Brehmer2, Lennart Martens1 1 VIB-UGent, B-9000 Ghent, Belgium 2 Janssen Pharmaceutica NV, 2340 Beerse, Belgium
P-870 RESPONSE OF PEPTIDE INTENSITY TO CONCENTRATION IN ESI¨CMS-BASED PROTEOME Wenyuan Lu1, Xuefei Yin1, Xiaohui Liu1, Guoquan Yan1, Pengyuan Yang1 1 Fudan University, Shanghai 200433, China
260 P-871 A SPATIALLY-AWARE PEAK PICKING METHOD FOR MALDI-IMAGING DATA FROM TOF AND FTICR MASS ANALYZERS Jan Hendrik Kobarg1,2, Lena Hauberg-Lotte1,3, Michaela Aichler4, Michael Becker5, Janina Oetjen3, Judith Berger6, Stefan Heldmann6, Axel Walch4 Dennis Trede2,7 Theodore Alexandrov1,2,3,7 1 Steinbeis Innovation Center SCiLS Research, Bremen, Germany 2 Center for Industrial Mathematics, University of Bremen, Germany 3 MALDI Imaging Lab, University of Bremen, Germany 4 Institute of Pathology, Helmholtz Center Munich, Germany 5 Bruker Daltonics, Bremen, Germany 6 Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany 7 SCiLS GmbH, Bremen, Germany
P-872 APPLICATION OF NON-SELECTIVE PHOTOREACTIVE CROSS-LINKING IN MASS SPECTROMETRY-BASED STRUCTURAL PROTEOMICS Pang-Hung Hsu1, Kuan-Chieh Peng1 National Taiwan Ocean University
P-873 AUTOMATED AND COMPREHENSIVE SITE-SPECIFIC CHARACTERIZATION OF GLYCOPROTEINS USING PROTEOLYTIC ENZYMES WITH HIGH AND LOW SPECIFICITIES Evan Parker1, Andres Guerrero1, Michael Xin Sun1, Jincui Huang1, Carlito Lebrilla1 1 UC Davis
P-874 AN HMSILAC-BASED ANALYSIS PIPELINE WHICH ENABLES ACCURATE ASSIGNMENT AND QUANTIFICATION OF METHYLATED SITES BETWEEN DISTINCT FUNCTIONAL STATES Michael Bremang1, Alessandro Cuomo1, Valeria Spadotto1, Tiziana Bonaldi1 1 European Institute Of Oncology
P-875 A SPATIALLY-AWARE PEAK PICKING METHOD FOR MALDI-IMAGING DATA FROM TOF AND FTICR MASS ANALYZERS Jan Hendrik Kobarg1,2, Lena Hauberg-Lotte1,3, Michaela Aichler4, Michael Becker5, Janina Oetjen3, Judith Berger6, Stefan Heldmann6, Axel Walch4 Dennis Trede2,7 Theodore Alexandrov1,2,3,7 1 Steinbeis Innovation Center SCiLS Research, Bremen, Germany 2 Center for Industrial Mathematics, University of Bremen, Germany 3 MALDI Imaging Lab, University of Bremen, Germany 4 Institute of Pathology, Helmholtz Center Munich, Germany 5 Bruker Daltonics, Bremen, Germany 6 Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany 7 SCiLS GmbH, Bremen, Germany
261 P-876 INTEGRATED AND COMPARATIVE ANALYSIS OF 3-OMICS DATA TO IDENTIFY A PANEL OF DIFFERENTIALLY EXPRESSED MEMBRANE PROTEINS IN BENIGN AND METASTATIC PROSTATE CANCER CELLS LINES. Satya Saxena1, Joe Shambaugh2, Jessica Qi2, Islay Campbell2, Matthew Todd1 1 Janssen Research & Development, Spring House, PA, USA 2 Genedata Inc., Lexington, MA, USA
P-877 IDENTIPY, AN OPEN-SOURCE MS/MS DATA SEARCH PLATFORM FOR SHOTGUN PROTEOMICS Lev I. Levitsky1, 2, Mark V. Ivanov1, 2, Anna A. Lobas1, 2, Marina L. Pridatchenko1, Irina A. Tarasova1, Kristina Srzentic3, Yury O. Tsybin3, Goran Mitulovic4 Mikhail V. Gorshkov1, 2 1 Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia 2 Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia 3 Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 4 Medical University of Vienna, Vienna, Austria
P-878 REANALYSIS OF PUBLIC DATA TO FIND NON-STANDARD PHOSPHORYLATIONS IN HUMAN SAMPLES Attila Csordas1, Steven Lewis1, James C. Wright2, Pedro Beltrao1, Henning Hermjakob1, Jyoti S. Choudhary2, Juan A. Vizcaíno1 1 European Bioinformatics Institute (EMBL-EBI) 2 The Wellcome Trust Sanger Institute
P-879 MZJAVA: AN OPEN SOURCE MASS SPECTROMETRY LIBRARY Oliver Horlacher1,2, Frederic Nikitin1, Davide Alocci1,2, Julien Mariethoz1, Markus Muller1,2, Frederique Lisacek1,2 1 Swiss Institute Of Bioinformatics 2 University of Geneva
P-880 THE SEAMASS PLATFORM: A NEW LC-MS SOFTWARE PIPELINE BASED ON IMAGE ANALYSIS AND BAYESIAN MODELLING Hanqing Liao1, Yan Zhang1, Isabel Riba-Garcia1, Julian Selley1, Faviel Gonzalez2, Henning Hermjakob3, Richard Unwin1, Andy Jones2 Jeffrey Morris4 Andrew Dowsey1 1 University of Manchester 2 University of Liverpool 3 European Bioinformatics Institute 4 University of Texas MD Anderson Cancer Center
P-881 OPTIMAL SELECTION OF SAMPLES FOR MULTIPLEX SEROLOGICAL ASSAY VALIDATION Hannes Planatscher1, Angela Filomena1, Oliver Poetz1, Thomas O. Joos1, Nicole Schneiderhan-Marra1 1 NMI
262 P-882 A COMPLETE WORKFLOW FOR ACHIEVING HIGH ACCURACY MULTIPLEXED N-TERMINOMICS DATA USING TMT10PLEX. Michael Blank1, Theo Klein2, Shane Fung3,4, Wilfred Tang5, Marhsall Bern5, Bernard Delanghe6, Rosa Viner6, Andreas Huhmer1 Stuart Turvey3,4 Christopher M. Overall2 1 Thermo Fisher Scientific, San Jose CA, USA 2 University of British Columbia, Centre for Blood Research, Vancouver, BC 3 British Columbia Children’s Hospital, Child and Family Research Institute, Vancouver, BC 4 University of British Columbia, Vancouver, CT 5 Protein Metrics, San Carlos, USA 6 Thermo Fisher Scientific, Bremen, DE
P-883 LOCATING POST TRANSLATIONAL MODIFICATIONS THROUGH THE INTERROGATION OF SHOTGUN PROTEOMICS Greg Mann1, Hiren Joshi1, Christopher Petzold1, Joshua Heazlewood1 1 Lawrence Berkeley National Laboratory
P-884 STATISTICAL CONFIRMATION OF MALDI-TOF MASS SPECTRA WITH R AND MASSUP CAN BE USED TO DISTINGUISH BETWEEN BACTERIA Tiago Santos1,2, José Capelo3,4, Irene Oliveira5, Hugo Santos3,4, Catarina Marinho1,2, Patrícia Poeta6,7, Gilberto Igrejas1,2, 1 Institute for Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal 2 Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal 3 Bioscope Group, Department of Chemistry, Faculty of Science and Technology, Nova de Lisboa University, Caparica, Portugal 4 REQUIMTE, Department of Chemistry, Faculty of Science and Technology, Nova de Lisboa University, Caparica, Portugal 5 Centre for the Research and Technology of AgrP-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal 6 Centre of Studies of Animal and Veterinary Sciences, Vila Real, Portugal 7 Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
P-885 A STAND-ALONE VERSION OF MS AMANDA FOR INTEGRATION INTO PROTEOMICS WORKFLOWS Viktoria Dorfer1, Peter Pichler2, Thomas Stranzl2, Gerhard Dürnberger3,2,4, Stephan Winkler1, Karl Mechtler2,4 1 University of Applied Sciences Upper Austria, Bioinformatics Research Group, 4232 Hagenberg, Austria 2 IMP - Research Institute of Molecular Pathology, 1030 Vienna, Austria 3 GMI - Gregor Mendel Institute of Molecular Plant Biology, 1030 Vienna, Austria 4 IMBA - Institute of Molecular Biotechnology, 1030 Vienna, Austria
P-886 PEPTIDE-CENTRIC DATABASE SEARCH ENGINES APPLIED TO DATA INDEPENDENT ACQUISITION UDMSE DATA Pedro Navarro1, Jennifer Hahlbrock1, Joerg Kuharev1, Ute Distler1, Stefan Tenzer1 1 Institute For Immunology, University Medical Center Of The Johannes Gutenberg University Mainz
263 P-888 ESTIMATION OF PROTEIN EXPRESSION PROFILES BASED ON PEPTIDE FEATURES AND QUANTIFICATION USING ISOBARIC LABELLING Martina Fischer1, Bernhard Y. Renard1 1 Robert Koch-Institute, 13353 Berlin, Germany
P-889 MZDB: A FILE FORMAT USING MULTIPLE INDEXING STRATEGIES FOR THE EFFICIENT ANALYSIS OF LARGE LC-MS/MS AND SWATH-MS DATASETS David Bouyssié1,2, Marc Dubois1,2, Sara Nasso3, Anne Gonzalez de Peredo1,2, Odile Burlet-Schiltz1,2, Ruedi Aebersold3,4, Bernard Monsarrat1,2 1 CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); 205 route de Narbonne, F-31077 Toulouse, France 2 Université de Toulouse; UPS; IPBS; F-31077 Toulouse, France 3 Department of Biology, Institute of Molecular Systems Biology, ETH, Auguste-Piccard-Hof 1, ETH Hönggerberg, CH-8093 Zürich 4 Faculty of Science, University of Zurich, Zurich, Switzerland
P-890 UNIPROT REFERENCE PROTEOMES FOR PROTEOMICS IDENTIFICATIONS Emanuele Alpi1, Maria Martin1, UniProt Consortium1, 2, 3 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) 2Swiss Institute of Bioinformatics 3Protein Information Resource
P-891 ISOQUANT - AN INTEGRATED BIOINFORMATICS PIPELINE FOR EVALUATION AND REPORTING OF DATA INDEPENDENT (LC-MSE) LABEL-FREE QUANTITATIVE PROTEOMICS DATA Joerg Kuharev1, Pedro Navarro1, Ute Distler1, Hansjoerg Schild1, Stefan Tenzer1 1 Institute For Immunology, University Medical Centre Of The Johannes Gutenberg University Mainz
P-892 NEW FUNCTIONALITY FOR THE TRANS-PROTEOMIC PIPELINE: TOOLS FOR THE ANALYSIS OF PROTEOMICS DATA Luis Mendoza1, David Shteynberg1, Joseph Slagel1, Michael Hoopmann1, Henry Lam2, Jimmy K. Eng3, Eric W. Deutsch1, Robert L. Moritz1 1 Institute For Systems Biology 2 Hong Kong University of Science and Technology 3 University of Washington
264 P-893 CONCEPT OF JAPAN PROTEOME STANDARD REPOSITORY/DATABASE (JPOST) Shin Kawano1, Yasushi Ishihama2, Tadashi Yamamoto3, Shujiro Okuda3, Takeshi Tomonaga4, Masaki Matsumoto5, Hirofumi Nakagami6, Tadashi Kondo7 Masaya Ono7 Sumio Ohtsuki8 Norie Araki8 1 Database Center For Life Science, Chiba, Japan 2 Kyoto University, Kyoto, Japan 3 Niigata University, Niigata, Japan 4 National Institute of Biomedical Innovation, Osaka, Japan 5 Kyushu University, Fukuoka, Japan 6 RIKEN, Kanagawa, Japan 7 National Cancer Center, Tokyo, Japan 8 Kumamoto University, Kumamoto, Japan
P-894 COLIMS: AN OPEN SOURCE LIMS SYSTEM TO AUTOMATE AND EXPEDITE PROTEOMICS DATA MANAGEMENT, PROCESSING AND ANALYSIS Niels Hulstaert2 1 Ghent University 2 VIB
P-895 SOFTWARE-SUITE FOR INTELLIGENT PROTEOME ANALYSIS AND BIOMARKER SEARCH ADAPTED TO AN AUTOMATED HIGH THROUGHPUT WORKFLOW Sindy Wendler1, Heidrun Rhode1, Benedikt Hanf2 1 University Hospital Jena, Jena, Germany 2 X-CASE GmbH, Ilmenau, Germany
P-896 SIMULTANEOUS LOCALIZATION AND ASSIGNMENT OF DIFFERENT POST-TRANSLATIONAL MODIFICATIONS USING PTMRS Etienne Beltzung1,2,, Thomas Taus1,2, Gerhard Duernberger1,2,3, Johannes Stadlmann1,2, Dea Slade4, Karl Mechtler1,2 1 Research Institute of Molecular Pathology (IMP) 2 Institute of Molecular Biotechnology (IMBA) 3 Gregor Mendel Institute of Molecular Plant Biology 4 Mas F. Perutz Laboratories,
P-897 MYMRM: A SOFTWARE TOOL FOR DESIGNING AD-HOC MRM EXPERIMENTS Gorka Prieto1, Kerman Aloria2, Javier Beaskoetxea3, Jesus Maria Arizmendi3 1 Department of Communications Engineering, University of the Basque Country (UPV/EHU), Alda. Urquijo s/n, Bilbao, 48013, Spain 2 Proteomics Core Facility-SGIKER, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n, Leioa, 48940, Spain 3 Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n, Leioa, 48940, Spain
265 P-898 MQRUN — INTEGRATING MAXQUANT INTO A LINUX CLUSTER-BASED WORKFLOW SYSTEM Adrian Seyboldt1, David Wojnar1, Sven Nahnsen1 1 Quantitative Biology Center (QBiC), Tübingen, Baden-Württemberg, Germany
P-899 ORGANIZE & ANALYZE YOUR MASS-SPECTROMETRY DATASETS ACCORDING TO YOUR EXPERIMENTAL DESIGN WITH PROLINE. David Bouyssié1, Véronique Dupierris2, Nicolas Barthe-Dejean1, Alexandre Burel3, Marc Dubois1, Laurent Martin2, Jean-Philippe Menetrey2, Alexandre Walter3 Jérôme Garin2 Christophe Bruley2 1 CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); 205 route de Narbonne, F-31077 Toulouse, France 2 Laboratoire Biologie à Grande Echelle, U1038 INSERM/CEA/UJF, iRTSV, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9 3 Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), IPHC-DSA, CNRS UMR7178, 4Université de Strasbourg, 25 rue Becquerel, 67087 Strasbourg
P-900 DIRECT QUATITATIVE ANALYSIS OF NATIVE HUMAN PEPTIDES IN COMPLEX SECRETOME SAMPLES Baozhen Shan1, Martijn Pinkse2, Bharath Kumar Raghuraman2, Cassandra Wigmore1, Peter Verhaert2 1 Bioinformatics Solutions Inc, Waterloo, ON, Canada 2 Delft University of Technology, Delft, NETHERLANDS
P-901 FROM DATA NORMALIZATION TO STATISTICAL SIGNIFICANCE: QUANTITATIVE PERFORMANCE OF LABEL FREE LC-MS PLATFORMS EVALUATED Marianne Sandin1, Aakash Chawade1, Fredrik Levander1 1 Department of Immunotechnology, Lund University, Lund, Sweden
P-902 SIMULATED LINEAR TESTS APPLIED TO QUANTITATIVE PROTEOMICS Thang V. Pham1, Connie R Jimenez1 1 OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center
266 23 - Human Proteome Project
P-903 CABA IN ISSUE IN NEPAL Sudip Bhattarai1, Pooja Kunwar2 1 Health Research And Social Development Forum 2 Young key affected population
P-904 MASS SPECTROMETRY BASED DRAFT OF THE HUMAN PROTEOME Bernhard Kuster1, Mathias Wilhelm1, Judith Schlegl2, Hannes Hahne1, Amin Moghaddas Gholami1, Marcus Lieberenz2, Mikhail Savitski3, Karsten Schnatbaum4 Marcus Bantscheff3 Franz Faerber2 1 Technische Universität München 2 SAP AG 3 Cellzome 4 JPT Peptide Technologies
P-905 TERMINI ORIENTATED PROTEOMICS-HUMAN AMINO TERMINOME (TOP-HAT) FOR THE HUMAN PROTEOME PROJECT: N TERMINI AND NA-ACETYLATION STATUS DIFFERENTIATE STABLE CLEAVED PROTEIN SPECIES FROM CLEAVAGE REMNANTS Christopher Overall1 1 University Of British Columbia
P-906 SIZE OF HUMAN PROTEOME: EXAMPLE OF CHR 18 Alexander Archakov1 1 Institute Of Biomedical Chemistry RAMS
P-907 PROTEOMIC EVALUATION OF LOW- AND HIGH-FLUX HEMODIALYSIS Danika Tognotti1, Carlo Donadio2 1 Cnr 2 Clinical and Experimental Medicine - Nephrology, University of Pisa
P-908 PROTEOME OF THE HUMAN FULL TERM PLACENTA Behrouz Gharesi-Fard1,2,3, Eskandar Kamali-Sarvestani1,3,4 1 Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran 2 Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 3 Proteomics laboratory, School of advanced medical sciences and technologies, Shiraz, Iran 4 Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
267 P-909 THE HUMAN DIABETES PROTEOME PROJECT (HDPP): 13TH HUPO WORLD CONGRESS IN MADRID Domitille Schvartz1, Peter Bergsten2, Kwang-Hyun Baek3, Ana Barba De La Rosa4, James Cantley5, Natacha Turck1, Andreas Wiederkehr6, Ioannis Xenarios7, 8 Jean-Charles Sanchez1 Martin Kussmann6, 9, 10 1 University Of Geneva, Geneva, Switzerland 2 Uppsala University, Uppsala, Sweden 3 CHA University, Seongnam, Republic of Korea 4 Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosi, Mexico 5 University of Oxford, Oxford, United Kingdom 6 Nestlé Institute of Health Sciences, Lausanne, Switzerland. 7 Swiss Institute of Bioinformatics, Lausanne, Switzerland 8 Swiss Institute of Bioinformatics, Geneva, Switzerland 9 Ecole Polytechnique Fédérale Lausanne (EPFL), Lausanne, Switzerland 10 Aarhus University, Aarhus, Denmark
P-910 THE HUMAN SURFACEOME Ulrich Omasits1, Sebastian Müller1, Damaris Bausch-Fluck1, Bernd Wollscheid1 1 Institute of Molecular Systems Biology, ETH Zürich, Switzerland
P-911 SUBCELLULAR FRACTIONATION ANALYSIS OF PLACENTAL TISSUE MEMBRANE PROTEINS FOR IDENTIFICATION OF MISSING PROTEIN. Jong-Sun Lim1, Keun Na1, Seul-Ki Jeong1, Min-Jung Lee1, Jin-Young Cho1, Young-Ki Paik1,2, 1 Yonsei Proteome Research Center, Seoul, Korea 2 Dept of Integrative Omics for Biomedical Science and Dept of Biochemistry, College of Life Science & 3 Biotechnology, Yonsei University, Seoul, Korea
P-912 SIMULTANEOUS TARGETED ANALYSIS OF FIVE OSTEOARTHRITIS BIOMARKER CANDIDATES RELATED TO CHROMOSOME 16 BY LIQUID CHROMATOGRAPHY-MULTIPLE REACTION MONITORING MASS SPECTROMETRY Patricia Fernández Puente1, Valentina Calamia1, Jesus Mateos1, Carolina Fernández-Costa1, Lucia Lourido1, Beatriz Rocha1, Magali Mendez1, 1 Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, 15006 A 2Coruña-SPAIN. This study is integrated into the chromosome 16 Spanish Human Proteome Project.
P-913 SERUM BIOMARKERS OF ERYTHROPOIETIN RESISTANCE: ESTABLISHING AN OPTIMAL MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY WORKFLOW COMPATIBLE WITH HEXAPEPTIDE-BEAD LIBRARY AND ISOBARIC PEPTIDE TAGGING REAGENTS Michael Merchant1, Steven Hawkins1, Danny Wilkey1, Susmita Datta1, Jon Klein1, Michael Brier1 1 University Of Louisville, Louisville, KY USA
268 P-914 DEVELOPMENT OF IMPROVED SUBCELLULAR FRACTIONATION PROCEDURES OF THE PLACENTAL MEMBRANE PROTEINS FOR DISCOVERING DISEASE BIOMARKERS AND MISSING PROTEINS Jong-Sun Lim1, Seul-Ki Jeong1, Keun Na1, Min-Jung Lee1, Jin-Young Cho1, William Stephen Hancock2, Young-Ki Paik1 1 Yonsei Proteome Research Center, Seoul, Korea 2 Northeastern University, Boston, MA, USA
P-915 GENOMEWIDEPDB V 2.0: UPDATE ON THE TRANSCRIPTOMIC AND PROTEOMIC EXPRESSION DATA WITH ALTERNATIVELY SPLICED PRODUCTS LAYERED IN A GENOME-WIDE MANNER Seul-Ki Jeong1, Keun Na1, Jong-Sun Lim1, William S. Hancock2, Young-Ki Paik1 1 Yonsei Proteome Research Center, Yonsei Univ., Seoul, Korea 2 Northeastern University, Boston, MA, USA
P-916 UNRAVELING THE PROTEOME OF NUCLEUS BASALIS OF MEYNERT Enrique Santamaría1, Joaquin Fernandez-Irigoyen1, Estela Perez1, Victoria Zelaya1 1 Navarrabiomed-Miguel Servet Foundation
P-917 IDENTIFICATION PROTEINS OF CARDIOVASCULAR SYSTEM IN HEALTHY SUBJECTS’ URINE DURING “DRY” IMMERSION Liudmila Pastushkova1, Igor Dobrokhotov1, Olga Obraztsova1, Aleksey Kononikhin1,2, Eugene Tiys3, Igor Popov2,4, Eugene Nikolaev2,4, Irina Larina1 1 Institute For Biomedical Problems Of RAS, Moscow,Russia 2 Institute for Energy Problems of Chemical Physics RAS, Moscow, Russia 3 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 4 Emanuel Institute of Biochemical Physics RAS, Moscow, Russia
P-918 BIOLOGICAL PROCESSES IN COSMONAUTS AFTER LONG DURATION SPACE FLIGHTS BY STUDYING URINE PROTEOME Irina Larina1, Luidmila Pastushkova1, Aleksey Kononihin1,2, Eugene Tiys3, Olga Obraztsova1, Igor Dobrohotov1, Igor Popov2,4,5, Kirill Kireev6 Vladimir Ivanisenko3 Eugene Nikolaev2,4 1 Institute For Biomedical Problems Of RAS 2 Institute for Energy Problems of Chemical Physics RAS, Moscow, Russia 3 3Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 4 Emanuel Institute of Biochemical Physics RAS, Moscow, Russia 5 Moscow Institute of Physics and Technology, Moscow, Russia 6 Gagarin Cosmonauts Training Center, Star City, Moscow region, Russia
P-919 HIGH-THROUGHPUT EVALUATION OF ANTIBODIES ON WESTERN BLOT WITHIN THE HUMAN PROTEIN ATLAS PROJECT Klas Linderbäck1, Marica Hamsten1, Jenny Ottosson Takanen1, Annelie Cajander1, Anna Johansson1, Delaram Afshari1, Atefeh Mohsenchian1, Mona Moradi1 Camilla Ohlsson1 Mattias Uhlén1 1 Royal Institute Of Technology/School Of Biotechnology
269 P-920 INFLUENCE OF EXPERT TEST WITH LARGE RADIUS CENTRIFUGE ROTATION ON URINE PROTEOM OF COSMONAUTS Kirill Kireev1, Luidmila Pastushkova2, Vladimir Pochuev1, Aleksey Kononikhin2,3, Irina Larina2 1 Gagarin Cosmonauts Training Center, Star City, Moscow Region, Russia 2 Institute For Biomedical Problems Of RAS, Moscow,Russia 3 Institute for Energy Problems of Chemical Physics RAS, Moscow,Russia
P-921 CELL TO GEL WORKFLOW: A STREAMLINED PROTEOMICS WORKFLOW FOR MINIMIZING SAMPLE PREPARATION AND MAXIMIZING PROTEIN SAMPLE UTILIZATION. Kenneth Oh1, Ning Liu1, Matthew Hammond1, Jonathan Kohn1, Anton Posch2, Nancy Braun2 1 BiP-Rad Laboratories, Hercules, California, U.S.A. 2 BiP-Rad Laboratories, Munich, Germany
P-922 PROTEOMIC BIOMARKER ANALYSIS OF MATERNAL SERUM FOR IDENTIFICATION OF PRETERM LABOUR Arlene D’Silva1, Jon Hyett, Jens Coorssen 1 University Of Sydney, University of Western Sydney, Royal Prince Alfred Hospital, Sydney, NSW, Australia 2 Obstetrics, Gynaecology and Neonatology, Central Clinical, Royal Prince Alfred Hospital, University of Sydney, Sydney. NSW, Australia 3 School of Medicine Nanoscale Organisation & Dynamics Group School of Science & Health University of Western Sydney NSW, Australia
P-923 ANTIBODY RANKER Tadashi Yamamoto1, Naohiko Kinosita1, 2 1Niigata University 2Niigata University of Health and Welfare
P-924 MITOCHONDRIAL PROTEOME OF CYBRID CELLS HARBOURING A TRUNCATIVE MITOCHONDRIAL DNA MUTATION IN RESPIRATORY COMPLEX I Clara Musicco1, Antonella Cormio2, Maria Antonietta Calvaruso3, Luisa Iommarini3, Giuseppe Gasparre3, Anna Maria Porcelli3, Anna Maria Timperio4, Lello Zolla4 Maria Nicola Gadaleta1 1 CNR - Institute of Biomembranes and Bioenergetics, Bari, Italy 2 University of Bari, Bari, Italy 3 University of Bologna, Bologna, Italy 4 Tuscia University, Viterbo, Italy
P-925 QUANTITATIVE HUMAN TEARS PROTEOME IN SHORT-TERM DECORATIVE CONTACT LENS WEAR Jingfang Bian1, King Kit Li, Chi-ho To, Carly S. Lam, Thomas Chuen Lam The Hong Kong Polytechnic University, Hong Kong
270 P-926 PROTEOMIC ANALYSIS OF THE SPERM CELL: TOWARDS THE COMPLETE SPERM CELL PROTEOME AND IDENTIFICATION OF PROTEINS INVOLVED IN MALE INFERTILITY Carla Paiva1,2, Claudio Attardo Parrinello1, Judit Castillo1, Ruben Azpiazu1, Alexandra Amaral1, 2, Orleigh Bogle1, Montserrat Codina1, Josep Maria Estanyol3 Josep Lluís Ballescà4 Rafael Oliva1 1 Human Genetics Research Group, Faculty Of Medicine, University Of Barcelona, IDIBAPS And 2 Hospital Clinic From Barcelona 3 PhD Programme in Experimental Biology and Biomedicine, CNC-Center for Neuroscience and Cell 4 Biology and Institute for Interdisciplinary Research, and Biology of Reproduction and Stem Cell Group, 5CNC, University of Coimbra, Coimbra, Portugal 6 Proteomics Unit, Scientific and Technical Centers of the University of Barcelona (CCiTUB), Barcelona, Spain 7 Institute of Obstetrics, Gynecology and Neonatology, Hospital Clinic, Barcelona, Spain
P-927 MEASURING SUCCESS A PRIORI? THE REGULATION OF RESEARCH BY TRANSLATIONAL TENSIONS Mavis Jones1, Christina Holmes2, Fiona McDonald3 1 Canadian Cancer Society Research Institute, Toronto, Ontario, Canada 2 St. Francis Xavier University, Antigonish, Nova Scotia, Canada 3 Queensland University of Technology, Brisband, Queensland, Australia
P-928 URINE PROTEOMICS FOR THE DISCOVERY OF NON-INVASIVE DIAGNOSTIC BIOMARKERS FOR PEDIATRIC DISEASES Hanno Steen1, Alex Kentsis1, Susan Kim1, Rebekah Mannix1, Richard Bachur1 1 Boston Children’s Hospital, Boston, MA, USA
P-930 MITOCHONDRIAL PROTEOMICS INVESTIGATION OF A CELLULAR MODEL OF IMPAIRED DOPAMINE HOMEOSTASIS, AN EARLY STEP IN PARKINSON’S DISEASE PATHOGENESIS Tiziana Alberio1, Heather Bondi1, Luisa Pieroni2, Andrea Urbani2, Mauro Fasano1 1 University Of Insubria, Busto Arsizio, Italy 2 University of Roma “Tor Vergata”, Roma, Italy
P-931 CHARACTERIZATION OF CANCER-ASSOCIATED PROTEINS RELATED TO CHROMOSOME 16 J. Ignacio Casal1, Oriol Bachs1, Francesc Canals1, Josep M. Estanyol1, Manuel Fuentes1, Alberto Medina1, Javier Muñoz1, Fernando J. Corrales1 Juan P. Albar1 1 ProteoRed-ISCIII. Plataforma De Recursos Biomoleculares Y Bioinformáticos. Spain
P-932 DISECTING CHROMOSOME 16 PROTEOME Fernando J. Corrales1, Concha Gil1, Francisco Blanco1, Manuel M. Sánchez Del Pino1, Jesús Vázquez1, Javier Muñoz1, Enrique Santamaría1, Félix Elortza1 Eliandre Oliveira1 Francesc Canals1 Alberto Pascual-Montano1 Jesús M. Arizmendi, Josep Mª Estanyol, Silvia Barceló, Irene Orera, M. González-Barderas, Jaime Sancho, Fernando Vivanco, Manuel Fuentes, Eduard Sabidó 1 ProteoRed-ISCIII. Plataforma De Recursos Biomoleculares Y Bioinformáticos. Spain
271 P-933 THE SPANISH BIOLOGY/DISEASE INITIATIVE WITHIN THE HUMAN PROTEOME PROJECT Juan P. Albar1, Oriol Bachs1, Francesc Canals1, Ignacio Casal1, Fernando Corrales1, Manuel Fuentes1, Concha Gil1, Javier Muñoz1 Fernando Vivanco1 Francisco Blanco1 1 ProteoRed-ISCIII. Plataforma De Recursos Biomoleculares Y Bioinformáticos. Spain
P-934 TARGETING PROTEINS OF CHROMOSOME 16 Letizia Odriozola1, Nuria Colomé1, Francesc Canals1, María L. Hernáez1, Felipe Clemente1, Concha Gil1, Patricia Fernández1, Cristina Ruiz1 Irene Orera1 Silvia Barceló1 Miguel Marcilla1 Severine Gharbi, Fernando Vivanco, Eduard Sabido, Eva Pérez, Manuel M. Sánchez del Pino, Joaquín Fernández, Juan P. Albar, Fernando J. Corrales 1 ProteoRed-ISCIII. Plataforma de Recursos Biomoleculares y Bioinformáticos. Spain. Spanish Consortium of C-HPP (Chr-16)
P-935 SUBCELLULAR FRACTIONATION ENHANCES CHROMOSOME 16 PROTEOME COVERAGE Irene García-Palmero1, María López-Lucendo1, J. Alberto Medina-Aunon1, Kerman Aloria1, Jesús M. Arizmendi1, Francesc Canals1, Montserrat Carrascal1, Felix Elortza1 Josep Mª Estanyol1 Joaquín Fernández1 Anabel Marina1 Javier Muñoz, Eliandre Oliveira, Alberto Pascual-Montano, Manuel Sánchez Del Pino, Jesús Vázquez, Fernando J. Corrales, Juan P. Albar, J. Ignacio Casal 1 ProteoRed-ISCIII. Plataforma De Recursos Biomoleculares Y Bioinformáticos. Spain.
P-936 TRANSCRIPTOMIC PROFILING TOWARDS THE LOCALIZATION OF THE MISSING PROTEINS Elizabeth Guruceaga1, Fernando J. Corrales1, V. Segura1 1 ProteoRed-ISCIII. Plataforma De Recursos Biomoleculares Y Bioinformáticos. Spain. Spanish 2Consor- tium of C-HPP (Chr-16)
P-937 MISSING PROTEINS IN CHROMOSOME 16. SPANISH HPP Manuel Fuentes, Felipe Clemente, María Luisa Hernáez, María Gonzalez-Gonzalez, Fernando Corrales, Juan Pablo Albar, Concha Gil, 1 Cancer Research Center. University of Salamanca-CSIC, IBSAL. 2 Dpt. Microbiology & Proteomics Unit. University Complutense. Madrid 3 National Center of Biotechnology. CSIC. Madrid. 4 Center For Applied Medical Research (CIMA).Pamplona. SPAIN
P-938 THE CHROMOSOME 19 STRATEGY TO CHARACTERIZE NOVEL PROTEOFORMS AND MISSING PROTEINS USING ENCODE RESOURCES Carol L. Nilsson, Ekaterina Mostovenko, Cheryl F. Lichti, Kelly Ruggles, David Fenyö, Roger A. Kroes, Sophia Hober, Ákos Végvári, Melinda Rezeli, Per E. Andrén, Erik P. Sulman, Frederick F. Lang, Manuel Fuentes, Elisabet Carlsohn, Joseph R. Moskal, Jill A. Opsahl, Frode S. Berven, Thomas E. Fehniger, György Marko-Varga* Lund University, Sweden
272 24 - Late Break Abstract
P-1 2D PROTEOME EXPRESSION PATTERN IN ORAL SQUAMOUS CELL CARCINOMA OF EX- TRACTS FROM AGRIMONIA PILOSA LEDEBROOT Yeon Ju Kwak1, Park Kyoung Eun2, Hye Ock Jang2 1 Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea 2 Department of Dental Pharmacology and Biophysics, School of Dentistry and Research Institute For Oral Biotechnology, Yangsan Campus of Pusan National University, Beomeo-Ri, Mulgeum-Eup, Yangsan-Si, Gyeongsangnam-Do, 626-870, Korea
P-2 DIMETHYL LABELING AFFECTS RECOVERY OF SINGLY PHOSPHORYLATED PEPTIDES IN TIO2 CHROMATOGRAPHY Philipp Spät1,2, Karsten Krug2, Boris Macek2, Mirita Franz-Wachtel2 1 Institute of Microbiology, Organismic Interactions, University Tübingen, Germany, 2 Proteome Center Tübingen, University Tübingen, Germany
273 GENERAL INFORMATION
275 REGISTRATION TO THE CONGRESS
st th From July 1 to From September 23, Until July 8 , 2014 September 22, 2014 2014 (onsite) HUPO member * 450 € 550 € 650 €
HUPO non member 550 € 650 € 750 €
HUPO member 200 € 250 € 300 € Student ** HUPO non-member 275 € 325 € 375 € Student ** Accompanying 100 € person ***
VAT Included Registration fee includes: • Access to the Opening Session and the Welcome Reception • Access to the scientific sessions • Bag with Congress materials • Coffee during breaks • Certificate of attendance • FREE WIFI at the congress venue
Accompanying person fee includes: • Access to the Opening Session • Attendance to Welcome Cocktail • Access to the Commercial Exhibition area • Coffee during breaks
COURSES
Date Fee (VAT Included) Pre Congress Course 3th and 4th October 2014 200 €
Clinical Day Course 5th October 2014 75 €
Educational Day Course 5th October 2014 75 €
276 SOCIAL PROGRAM
OPENING CEREMONY (18:00-19:30) AND OPENING RECEPTION (19:45 - 21:30) SUNDAY 5 OCTOBER 2014
The Opening Ceremony will be held in the Auditorium, on the 1st floor of the North Congress Centre, IFEMA.
The Opening Ceremony will be provided with choreography of stylized dance based on the Albéniz music that brings us near to the purity and the roots of the Spanish dance. With this dance we can enjoy the Spanish elements such as the castanets, the fan and the footwork, all of these with a style that makes us travel into the past with the modern language of the Spanish dance. Mariemma School of Dance: “Por Derecho”. Choreography: Antonio Pérez. Music: Isaac Albeniz. Team “Larreal”.
The welcome reception will take place in the Pavilion 10 and it is included in the Registration Fee.
The welcome reception will be provided with a jazz quartet. The VT quartet will present selection of favorite all-time standards and songs that will surely please the senses and souls of any audience. Four accomplished musicians blend their talents and years of professional experience. Their goal is no other than to share their love for classy melodies, dear to our ears and memories. We sincerely hope that you enjoy them as much as we do.
CONGRESS DINNER TUESDAY 7 OCTOBER 2014, 21:00.
A sitting dinner, proceeding by a string quartet on the Glass Gallery, will be held in Cibeles Palace. His large glass dome, irregular in shape, serves as a roof to the over 2,400 m2 of this new space which constitutes an intrinsic component of the Madrid City Council’s new headquarters. It was part of the Retiro Royal Palace in the 17th century, and in the 19th century it housed a leisure garden. From 1904 to 1919, it was officially incorporated as a passageway and loading area for the Communications Palace which was designed by architects Palacios and Otamendi. The gallery, which as undergone extensive work, is now part of the Madrid City Council’s headquarters and is used to host both institutional acts and celebratory events. It has two entrances: Calle Alcalá, 50, and Calle Montalbán,1.
We have the satisfaction to present the wonderful artists that form the group “Cuarteto Madrid”. The quartet is compound by the following musicians: Anne Marie North, Antonio Cárdenas, Iván Martín y John Stokes. This group has been together since 2003 and even though they interpret music from all times and composers, their repertoire is based mainly on Spanish composers.
After dinner a live rock´n roll concert will be offered by the group Gate Doors.
277 GENERAL INFORMATION
SCIENTIFIC ABSTRACTS ON USB KEY The HUPO 2014 Abstracts will be available on a USB key. Participants will receive it in his Congress Bag. BADGES Name badges must be visible and used at all times, anywhere at the Congress Centre. CERTIFICATE OF ATTENDANCE Certificate of Attendance can be collected at the Registration Area (Self-Badge Printing desk) during Tuesday, 7 October 2014. The other types of certificates will be send by email. CONGRESS BAG Participants will receive a congress bag voucher with all the congress documents at the Registration Area (Congress Bags desk).
CONGRESS SECRETARIAT HUPO 2014
TILESA KENES SPAIN C/Londres, 17 28028, Madrid Tel: + 34 91 361 26 00 Fax: +34 91 355 9208 E-mail: [email protected] Website: http://www.hupo2014.com/ EXHIBITION AREA INFORMATION The HUPO 2014 Exhibition, featuring commercial displays of International Organizations, Pharmaceutical Companies, Media Publishers and Scientific Societies, will be located in Pavilion 10 of the North Congress Centre, IFEMA. Catering facilities and Poster Sessions will also be located in the Exhibition hall. EXHIBITION AREA SCHEDULE Sunday 5 October 17:30h - 21:30h Monday 6 October 08:00h - 20:00h Tuesday 7 October 08:00h - 20:00h Wednesday 8 October 08:00h -16:00h COFFEE BREAKS Coffee breaks are included in the Registration Fee. They will be served in the Exhibition Hall in the Pavilion 10, from Monday 6 to Wednesday 8 September. INTERNET Free WIFI is provided in Pavilion 10 and the North Convention Center, IFEMA. HUPO OFFICE The Technical Secretariat will be located in the hall of the North Convention Center, IFEMA.
278 LANGUAGE The official language of the 13th Human Proteome Organization World Congress is English. POSTER SESSIONS Posters will be displayed for the duration of the poster session. Poster presenters have been scheduled to be by their poster according to the program times. Odd numbers will be presented on Monday 6 October; even numbers will be presented on Tuesday 7 October. Wednesday 8 October remains for free presentations.
TECHNICAL SECRETARIAT The Technical Secretariat at North Convention Center will be open as follows: Sunday 5 October 08:00h - 19:30h Monday 6 October 07:30h - 20:00h Tuesday 7 October 07:30h - 20:00h Wednesday 8 October 07:30h - 19:30h
RULES Smoking Policy - The HUPO 2014 Congress is a non-smoking event. Participants are kindly requested to refrain from smoking in the Congress venue, including the Exhibition Area.
Mobile Phones - Delegates are kindly requested to keep their mobile phones in the off position in the rooms where scientific and educational sessions are being held, as well as during poster sessions. TRANSPORTATION By Metro: Access to IFEMA is possible from anywhere in the city by means of Campo de las Naciones station on Line 8, whose exit is at the South Entrance of the complex. Line 8 also connects the exhibition complexes with the different terminals of Barajas International Airport.
By Bus: A wide bus network provides access to Feria de Madrid from different points in the city: Route 112-Mar de Cristal-Feria de Madrid-Bº Aeropuerto. Route 122-Avda. de América-Campo de las Naciones-Feria de Madrid. Route 828-Universidad Autónoma-Alcobendas-Canillejas-Feria de Madrid.
By Taxi: With ranks at each entrance to the exhibition complex, more than 15,000 taxis are available to visitors to Feria de Madrid.
By car: Feria de Madrid is linked by road to Madrid’s major access routes and ring roads: the M11 (Exits 5 and 7), the M40 (Exits 5, 6 and 7) and the A2 (Exit 7). The South, North and East Entrances to the exhibition complex provide direct access to the various parking areas. SPEAKER PREVIEW ROOM Please ensure that you have visited the Speaker Preview Room to confirm your audiovisual requirements at least 2 hours prior to the start of your session. However, it is recommended speakers register with the Speaker Preview Room the day before their presentation. The Speaker Preview Room is located at the entrance of the Congress Centre.
Opening times are as follows: Sunday 5 October 08:00h - 19:30h Monday 6 October 07:30h - 20:00h Tuesday 7 October 07:30h - 20:00h Wednesday 8 October 07:30h - 19:30h 279 LOCATION MAP
Secretariat North Gate Exhibition Meeting Rooms Congress Entrance Poster Area
South Gate Campo de las Naciones
280 NORTH GATE - FLOOR 0
Main Entrance North Gate
Access to Rooms
Prepaid Registrations Technical Secretariat
Access to EXHIBITION & POSTER AREA
FLOOR 1 - MEETING ROOMS
281 EXHIBITION FLOOR PLAN
1 Posters 2 Posters 3 4 11 12 13 14 15
5 19 20 7 21 Posters 8 23 24
9 26
10
27
C Posters P 16 22 18 25 30
31 33 Posters 35 38
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Posters Posters
282 Exhibitor List
COMPANY BOOTH Nº ABCAM 4 ABSciex 27 Agilent Technologies 10 Avacta Life Sciences 21 Bioinformatics Solutions 35 Bio-Rad 30 Bruker 26 Cambridge Isotopes 23 Cell Signaling 34 Denator 24 Elsevier 8 EuPA 16 Euriso-Top 3 HUPO2015 18 JPT Peptide Tecnologies 15 Luminex 9 Media Corner 5 MyCartis 19 Pressure Biosciences 38 Protein Simple 11 ProteoRed 22 PTM Biolabs 12 SEProt 25 Sigma Aldrich 31 Silantes 1 Thermo Fisher 14 Total Lab LTD 2 Waters S.A.S 20 Wiley 7
283 CALL FOR PAPERS
http://ees.elsevier.com/jprot/
Journal of Proteomics: Special Issue: HUPO 2014
Guest Editors: Fernando J Corrales, Juan Calvete, Concha Gil
Submission Deadline: December 1st, 2014
The Scientific Committee is pleased to announce that a Special Issue containing selected papers from the HUPO 2014 will be published in the Journal of Proteomics. All manuscripts will be refereed according to the scientific standards of the journal.
Those wishing to submit a review article, full-length article or technical reports for publication in the Special Is- sue, will have the option to do so online as of 1 October 2014. Please note that the deadline for submission is 1 December 2014.
In order to avoid delays in publication of the special issue, only papers requiring no or minor revision will be accepted for the special issue. Papers requiring major revision can be considered for later regular issues. The scientific quality of papers clearly falling within the scope of the Issue will be the only criteria for manuscript acceptance.
The use of colour is free in your article. Illustrations enhance the educational value of your article; the journal will publish a high resolution version of your artwork in the html version of your article, for easy downloading into PowerPoint slides shows. There are no page or figure restrictions – scientific quality and relevance are the main criteria.
Upon publication the corresponding author will at no cost, be provided with a personalized link providing 50 days free access to the final published version of the article on ScienceDirect. This link can also be used for sharing via email and social networks. The corresponding author will also receive 1 free copy of the issue.
Instructions for submission: All manuscripts and any supplementary material should be submitted through the online submission system 284http://ees.elsevier.com/jprot Please select article type “HUPO 2014”. The covering letter of the article should be addressed to the Guest Editors and clearly indicate if the submission is a review, original article or technical report.
Further information regarding preparation and submission can be found in the Guide for Authors at http://www.elsevier.com/journals/journal-of-proteomics/1874-3919/guide-for-authors For more information please contact: Jasmin Bakker [email protected] Company Profiles
ABCAM Booth Nº4 www.abcam.com
Discover more with our high-quality protein research tools, expert technical support, fast global delivery, and up-to-date and honest data. Our growing range of products include primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits. Products are made in-house, as well as sourced externally, and are extensively tested.
ABSCIEX Booth Nº27 www.absciex.com
AB Sciex is the world leader in delivering innovative technologies that accelerate scientific discovery. By partnering with leading industry scientists, AB Sciex has developed a comprehensive portfolio of mass spectrometry systems and tools that places the power of discovery and research into the hands of researchers and analysts. Our solutions allow you to dig deeper into complex biological systems, analyze prospective biomarkers, and deliver results with potential use in clinical applications and translational medicine. Stop by our booth to discover our latest innovations and to learn how our customers are applying our technologies to solving dynamic and complex scientific questions.
AGILENT TECHNOLOGIES Booth Nº10 www.agilent.com
Agilent Technologies offers a complete portfolio of proteomics products for every step of the workflow, from sample prep through separation, detection, and analysis. Agilent’s products set the standard for precision, generating highly reproducible and reliable data for your protein analysis research. Continuing what has become a tradition at HUPO meetings, Agilent Technologies is pleased to host the “Meeting of the Minds” on 7th October. This event allows young scientists to meet with established leaders in Proteomics in a social environment.
285 Company Profiles
AVACTA LIFE SCIENCES Booth Nº21 www.avactalifesciences.com Unit 651 Street 5, Thorp Arch Estate, Wetherby, LS23 7FZ, United Kingdom +44 (0)844 963 2960
Avacta Life Sciences produces small and robust custom affinity proteins called Affimers. Affimers are an engineered alternative to antibodies which have been designed to address many of the issues that life science researchers have to overcome – specificity, batch to batch variability, the time it takes to generate new antibodies and limitations on target space. Our turnaround time for standard projects is 7 weeks from receipt of 500 µg of your target material.
BIOINFORMATICS SOLUTIONS Booth Nº35 www.bioinfor.com
Bioinformatics Solutions Inc. develops advanced algorithms, providing solutions to fundamental bioinformatics problems. PEAKS is a complete software package for proteomics mass spectrometry data analysis. Starting from the raw instrument data, PEAKS effectively performs peptide and protein identification, PTM and mutation characterization, quantification (label and label free) as well as result validation, visualization and reporting. CHAMPS is a professional service for obtaining primary sequences of monoclonal antibodies with modifications. Its workflow includes sample digestion with multiple enzymes, high resolution LC-MS/MS at both survey scan and product scan, then de novo sequencing data analysis. Our experts can provide solutions to either data analysis only or the complete workflow.
BIO-RAD Booth Nº30 www.discover.bio-rad.com
Bio-Rad Laboratories is a world leader in providing a range of products for the life science research and diagnostic markets. The Life Science Group provides a wide range of laboratory instruments, apparatus, and consumables used in research, in functional genomics, proteomics and food safety. The products are based on technologies used to separate, purify, analyse, identify, and amplify biological materials such as proteins and DNA. Areas of biological research that we support can be categorised into 4 fundamental areas: Cell Biology, Genomics, Proteomics and Food Safety. For complete details of our comprehensive range of products contact your local office or visit www. discover.bio-rad.com.
286 Company Profiles
BRUKER DALTONIK GMBH Booth Nº26 www.bruker.com Bruker Daltonik GmbH Fahrenheitstrasse 4 - 28359 Bremen - Germany Phone: +49 (0)421-2205-0 - Fax: +49 (0)421-2205-104 - [email protected]
Bruker Daltonics provides a broad range of high performance, easy to use Mass Spectrometry (MS) and analytical separation systems. Bruker delivers a series of innovative, fully integrated solutions for Proteomics, Metabolomics and Clinical Research areas, including:
- Biomarker Discovery & Characterization - Qualitative and Quantitative Proteomics - PTM Analysis - Top-down Protein Characterization - Molecular Imaging in Tissue - Drug Research and Development - Microorganism Identification - Metabolite Discovery and Identification
By utilizing a product and technology portfolio which includes MALDI-TOF, UHR-QTOF, Ion Traps, FTMS as well as LC and GC systems, Bruker provides best solutions for the latest analytical questions.
CAMBRIDGE ISOTOPES Booth Nº23 www.isotope.com
Cambridge Isotope Laboratories, Inc. (CIL) is the world leader in the manufacture of stable isotope-labeled compounds (13C, D, 15N, 17O, 18O) used for quantitative MS-based proteomic applications. Key innovative products include MouseExpress® Lysine 13C6 mouse feed and MouseExpress® Lysine 13C6 mouse tissue, MouseExpress® Spirulina 15N mouse feed and MouseExpress® 15N mouse tissue, 99% enriched amino acids, SILAC reagents and kits, amino acids for peptide synthesis, dimethyl labeling reagents, 18O water for enzymatic labeling and intact heavy labeled proteins, and an INLIGHT™ Glycan Tagging Kit for the relative quantification of N-linked glycans by mass spectrometry.
287 Company Profiles
CELL SIGNALING Booth Nº34 www.cellsignal.com
Founded by research scientists in 1999, Cell Signaling Technology (CST) is a private, family- owned company with over 400 employees worldwide. Active in the field of applied systems biology research, particularly as it relates to cancer, CST understands the importance of using antibodies with high levels of specificity and lot-to-lot consistency. It’s why we produce all of our antibodies in house, and perform painstaking validations for multiple applications. And the same CST scientists who produce our antibodies also provide technical support for customers, helping them design experiments, troubleshoot, and achieve reliable results. We do this because that’s what we’d want if we were in the lab. Because, actually, we are www.cellsignal.com.
DENATOR Booth Nº24 www.denator.com
Denator produces instruments and consumables, based on the company’s proprietary sample preservation technology, within the life science and clinical research markets. The Stabilizor™ T1 enables scientists to ensure the quality and in vivo profile of biological samples, by immediate and complete inactivation of enzymatic activity otherwise causing sample change and degradation. Its additive free, and enables reliable analysis and quantification of proteins, peptides and their modifications. It can be used for all tissue types, fresh or frozen, allowing secure analysis also of stored samples. Stabilized samples have improved signal-to-noise ratio, enabling detection of low abundant molecules such as potential biomarkers.
288 Company Profi les
EuPa Booth Nº16 www.eupa2015.org
The European Proteomics Association (EuPA) is the federation of European national proteomics societies. It has been established to coordinate and integrate national initiatives within the proteomics field. The main objectives are to strengthen and promote fundamental research and applications, as well as education and training in all areas of proteomics throughout Europe. EuPA is a non-profit organisation.
EURISO-TOP Booth Nº3 www.eurisotop.com
Euriso-top is the European leading provider of stable isotope-labeled compounds (13C, 15N, 18O, D) for Mass spectrometry (MS) based proteomics which has become over the last decade an essential tool for biologists. L-Arginine, L-Lysine, MouseExpress®, Mouse Feed and Tissue, Spirulina, Cell Growth Media, Labeled Proteins are among a large variety of reagents which will help you in the quantification of your proteins. Suitable with various applications like SILAC, SILAM, Peptide Synthesis Reagents, Protein expression, Chemical tagging.
With over 20 years of experience, Euriso-top offers full satisfaction to its customers through a comprehensive technical and commercial support.
289 Company Profiles
IBA GmbH www.iba-lifesciences.com Rudolf-Wissell-Str.28 37079 Göttingen Tel.: +49-551-50672-0 Fax: +49-551-50672-181
IBA GmbH is covering with its proprietary products and services the entire production process of recombinant proteins. The combination of IBA´s proprietary Strep-tag® affinity purification technologies and StarGate® combinatorial cloning system provide optimal solutions for cloning, protein expression and purification as well as detection and immobilization of proteins.
HUPO www.hupo.org
The Human Proteome Organization (HUPO) is an international scientific organization representing and promoting proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training.
HUPO2015 Booth Nº18 www.hupo2015.com
Join us in Vancuver next year for the 14th HUPO World Congress September 27-30, 2015. More information available at www.hupo2015.com
290 Company Profiles
JPT PEPTIDE TECHNOLOGIES Booth Nº15 www.jpt.com
JPT Peptide Technologies is the leading provider of innovative peptide tools and services for applications in discovery and targeted proteomics, peptide biomarker discovery, proteome spanning T-cell epitope discovery and enzyme profiling. JPT is the inventor of the SpikeTides and SpikeMix concepts for low cost provision of small scale, isotopically labeled and quantified peptides & peptide pools for the development of high-thoughput SRM/MRM assays and absolute quantification of protein expression levels. These approaches have been translated into a variety of ready to use, heavy labeled proteotypic peptide collections related to Cytokines, Tumor Associated Antigens, Kinase Activations Loops, Cross Species Standards and more.
LUMINEX Booth Nº9 www.luminexcorp.eu
Luminex Corporation develops, manufactures and markets innovative biological testing technologies with applications throughout the clinical diagnostic and life science industries. The company’s open-architecture xMAP® and xTAG® Technologies enable large numbers of biological tests (bioassays) to be conducted and analyzed quickly, cost-effectively and accurately. Systems using xMAP technology perform discrete bioassays on the surface of color-coded beads known as microspheres, which are then read in a compact analyzer. Further information on Luminex Corporation or xMAP can be obtained at www.luminexcorp.eu.
MY CARTIS Booth Nº19 www.mycartis.net
“Evalution™ is Mycartis’ multiplex analysis platform tailored to the clinical research and pharmaceutical markets and designed to analyze a broad range of protein and nucleic acid-based biomarkers, delivering superior data quality and rapid results. Evalution™ provides an integrated reaction and detection environment and simultaneous analysis of large numbers of analytes per assay.”
291 Company Profiles
PRESSURE BIOSCIENCES Booth Nº38 www.pressurebiosciences.com
Pressure BioSciences, Inc. (“PBI”) (OTCQB: PBIO) develops and sells proprietary laboratory instrumentation and associated consumables based on Pressure Cycling Technology (“PCT”). PCT is a patented, enabling platform that uses cycles of hydrostatic pressure between ambient and ultra-high levels. PCT has proven applications in enhanced proteomic research, biomarker discovery, bio-therapeutics characterization, vaccine development, histology, and in many other fields. PBI will feature its new Barozyme HT48 for high throughput accelerated enzymatic digestion and its MicroPestle System for protein extraction from minute samples. In addition, PBI will showcase Constant Systems cell disruptors for small to pilot-scale protein extraction from yeast, bacteria, and other organisms.
PROTEIN SIMPLE Booth Nº11 www.proteinsimple.com
Our goal is simply to help researchers gain a better understanding of proteins and their role in disease. We develop and commercialize proprietary systems and consumables for protein analysis that ultimately help reveal new insights into the true nature of proteins. Our goal is to make protein analysis simpler, more quantitative and affordable. Our comprehensive portfolio of tools includes Simple Western systems that quantify protein expression and Biologics systems that probe the structure and purity of protein-based therapeutics.
PROTEORED Booth Nº22 www.proteored.org
The main objective of ProteoRed consortium is to coordinate and integrate activities of the Spanish proteomic facilities and services in a common network with a nodal structure, so they will support the whole development of the proteomic research in our country. For this purpose, ProteoRed has been constituted as a technological platform composed by six nodes, supporting 17 + 2 proteomic facilities placed all over Spain.
292 Company Profiles
PTM BIOLABS Booth Nº12 www.ptm-biolab.com
PTM Biolabs, Inc is the only organization specifically for providing superior proteomics services and manufacturing antibodies targeting to protein post-translational modifications (PTMs) and epigenetics. Our technology and products help to explore the most comprehensive PTM pathways, including acetylation, methylation, phosphorylation, ubiquitination, glycosylation, crotonylation, succinylation, malonylation, etc.
Our proteomics services provides customer-orientied analysis utilizing the integrated platform with premium PTM reagents, high-end mass spectrometry and unrivaled software application. This superior technology can be applied for PTM identification, global screening of enzyme substrates, quantification of PTM dynamics, and discovery of biomarker and drug targets in biomedical and pharmaceutical pre-clinical research.
Our PTM antibodies are the most comprehensive PTM reagents collection worldwide, offering unparalleled advantages for PTM proteomics.
SEPROT Booth Nº25 www.2.cbm.uam.es/seprot/
The Spanish Proteomics Society (SEProt) was founded in 2004 and it currently has about 200 members .The main objective of SEProt is “to promote the development of Proteomics in Spain”. This is to be done by encouraging scientific and technical research in the field of Proteomics, by promoting training, learning and formation in this field, and by sponsoring and facilitating the organization and/or participation of their members in national or international activities, courses, workshops and meetings and any kind of cooperation and interchange with other societies.
293 Company Profiles
SIGMA ALDRICH Booth Nº31 www.sigma-aldrich.com
SIGMA® Life Science offers a wide portfolio of innovative technologies, products and services spanning cell biology, proteomics, protein biochemistry, genomics, functional genomics, biomolecules and epigenetics. Through continued investment in innovation and quality we are the leading destination for life science researchers to access deep biological information and market leading products that improve the quality of life.
SILANTES Booth Nº1 www.silantes.com
Silantes activities are focused on the production and marketing of compounds labelled with stable isotopes (SI: 2H, 13C and 15N ) used in NMR structural analysis and quantitative mass spectrometry. Silantes is specialized on SILAC-products.
Silantes SI-platforms are:
- Heteronuclear NMR providing
- SI-labelled growth media for E.coli and yeast; - SI-labelled nucleotides (d/rNTP, NMPs);
- Quantitative proteomics providing
- SI-amino acids; - kits for cell culture-labelling (SILAC); - kits for in vivo-13C-lys-labelling of SILAC-mouse, SILAC-fly, SILAC-zebrafish etc. - Service for in vivo proteomics in mice
294 Company Profiles THERMO FISHER Booth Nº14 www.thermoscientific.com
Thermo Fisher Scientific is the world leader in serving science, enabling you to make the world healthier, cleaner and safer. With annual sales of more than $17 billion and 50,000 staff, we serve our customers worldwide within a broad range of markets and sectors.
With four premier brands we help solve analytical challenges from routine testing to complex research and discovery. Thermo Scientific is the leading brand for technology innovation and offers customers a complete range of high-end analytical instruments as well as laboratory equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions across all fields of proteomics research”.
TOTAL LAB LTD Booth Nº2 www.totallab.com
The Phoretix family of software for electrophoresis analysis was first produced in 1991. TotalLab was first released in 1999 representing a breakthrough in levels of automation and ease of use. Both were developed by Nonlinear Dynamics Ltd.
In 2002 ImageQuant TL™ (IQTL) was created for GE Healthcare by the TotalLab team based on TotalLab v2.
TotalLab Ltd was spun-off from Nonlinear in 2007 taking with it the Phoretix and TotalLab product ranges and, in 2009, a new management team was created to push forward new development projects required to satisfy changing market needs.
Now in 2013 SameSpots for 2D Gel analysis has moved over to TotalLab Ltd from Nonlinear Dynamics.
Nonlinear Dynamics continues to develop their leading-edge Progenesis range of software for LC- MS, Metabolomics and MALDI.
295 Company Profiles WATERS S.A.S Booth Nº20 www.waters.com
Waters is a leading resource for tailored analytical solutions to meet the demands of leading proteomics and biomarker discovery research laboratories. Building on more than 50 years of experience, our advanced systems provide the gold standard in data quality and efficiency for protein discovery, characterization, quantification, and validation. Waters’ patented innovations in UltraPerformance LC (UPLC), Ion Mobility Separation (IMS), and High Definition Mass Spectrometry (HDMS) provide uniquely powerful tools unmatched by conventional LC/MSbased strategies for the best qualitative and quantitative proteomics
296 Our Publishers
297 Agresta, Anna Maria 176 AUTHORS INDEX Águila, Angela Del 173 Águila, Ángela del 231 Aguilar-Lemarroy, Adriana 102 A Aguilera-Montilla, Noemí 214 Ahmad, Sartaj 121, 193 Aartsma-Rus, Annemieke 247 Ahmad, Shadab 224 Abadía, Javier 176 Ahmed, Nikhat 233 Abad, Maria 77 Ahn, Charlie 98 Abbasi, Cynthia 226 Ahn, Jung-Mo 163 Abbondio, Marcello 158 Ahn, Seone 98 Abdallah, Cosette 152 Ahn, Seong B 105 Abdollahi, Amir 118 Ahn, Seong Beom 99, 114 Aberger, Fitz 109 Ahn, Yeong Hee 102 Abersold, Ruedi 136 Aichler, Michaela 261 Abian, J. 35 Aich, Udayanath 204, 205 Abian, Joaquin 153, 213 Aiello, Donatella 115 Abián, Joaquín 213 Aiello, Lloyd P. 71 Abreu, Isabel A. 152 Aistrup, Stine 237 Acera, Arantxa 157 Aittokallio, Tero 182 Acharyya, Biplab 228 Ajioka, Jim 150 Ackermann, Doreen 240 A., Juan 226 Acosta-Martin, Adelina E 241 Akimov, Vyacheslav 135 Acquadro, Elena 175 Albadawi, Hassan 227 Acuto, O. 43 Albanese, Jenny 247 Acuto, Oreste 44 Albar, Juan P. 271, 272 Adachi, Jun 138, 149 Albar, Juan Pablo 6, 7, 125, 183, 272 ádal, Bohumil Oš 198 Alberio, Tiziana 229, 238, 271 ádal, Martin Oš 198 Albillos, Silvia M 192 Addis, Maria Filippa 105, 139, 158, Albo, Alessandra Giuliano 236 172, 210, 253 Albuquerque, Daniele 110 Adelina, Rogowska-Wrzesinska 250 Aldini, Giancarlo 179 Admon, A. 43 Alencar-Arruda, Josy 174 Admon, Arie 44, Aleshin, V. 196 151, 177 Alexander, Nancy J 193 Aebersold, Ruedi 57, 58, 62, 66, 75, Alexandre, Bruno 168 156, 167, 250, 264 Alexandre, Bruno M. 152 Aeby, Eric 121 Alexandrov, Theodore 21, 22, 36, 80, Afshari, Delaram 269 250, 261 Agar, Nathalie Y.R. 125 Alfadda, Assim A 144 Agbo, Daniela Besong 147 Alguacil, Luis Fernando 145 Aghdami, Nasser 137 Alhamdani, Mohamed 108 Agis, Hermine 109 Alhamdani, Mohamed Saiel Saeed 98
298 Ali, Liaqat 203 Andersson, Eni 223 Aliprantis, Antonious 194 Andrada, Elena 183 Allmaier, Guenter 128 Andrade, Thiago 174 Alloggio, Isabella 176 Andrási, Melinda 161 Almeida, Andreia 107, 168 András, Pungor 106 Almeida, Antonio Bugalho De 168 Andreasson, Ulrika 248 Almeida, Julia 108 Andrea, Zezza 164 Almeras, Lionel 209 Andren, Per 21 Almidani, Ghaith M 144 Andrén, Per E. 242, 272 Alm, Tove 74 Anedda, Roberto 172 Alocci, Davide 205, 262 Angelucci, Stefania 164, 211 Alomari, Munther 104 Angres, Brigitte 129 Alonso, Francisco J. 112 Anikanov, N.A 197 Alonso, Jana 145 Anikanov, Nikolay 131 Alonso-Orgaz, Sergio 140, 221 Anjo, Sandra 164, 257 Alonso, Santos 118 Anjum, Omar 226 Alonso-Tejerina, Erika 193 Ansari, Marc 241 Aloria, Kerman 265, 272 Antinori-Malaspina, Paola 241 Alphen, Carolien Van 154 Antonella, Riviello 164 Alpi, Emanuele 264 Antonella, Viola 198 Alsadhan, Abdulmajeed A 144 Antrix, Jain 117 Altelaar, A.F. Maarten 197 Antúnez, Alfredo 120 Altelaar, Maarten 113 Anurov, Maxim 166 Alvarez-Llamas, Gloria 139, 140, 222, Aparicio-Bautista, Diana I. 211 223, 246 Apte, Arun 205 Alves, Gilda 129 Araki, Norie 126, 129, 265 Alves, Paula M. 226 Arapidi, Georgij 131 Amalric, François 255 Arapidi, Georgy 131 Amann, Joseph M. 163 Arapidi, G.P 197 Amaral, Alexandra 271 Araujo, Ines M. 186 Ameling, Sabine 225 Araujo, Luis 163 Amir, Abdollahi 124 Aravamudhan, Sriram 35 Amirkhani, Ardeshir 240 Archakov, Alexander 267 Amoresano, Angela 174, 207 Archakov, Alexander A. 101 Anagnostopoulos, Athanasios 106, 173 Arcos, Raquel 183 Anagnou, Nicholas P. 107 Arens, Nadja 172 Anand, Samyuktha 98 Arighi, Cecilia 135 Ancheva, Lina 162 Arita, Danielle 205 Andell, Pontus 226 Arita, Lilian 205 Andersen, Kristin 123 Arizmendi, Jesús M. 271, 272 Andersen, Michael 188, 217 Arizmendi, Jesus Maria 265 Andersen, Vibeke 182 Arlorio, Marco 175 Anderson, N. Leigh 249 Armand, Florence 121
299 Armengaud, J 31 Azhar, Abid 256 Armengaud, Jean 32 Azkargorta, Mikel 105, 157, 208 Armengol, Carolina 105 Azpiazu, Ruben 271 Armini, Alessandro 175, 233 Azurmendi, Leire 157 Armstrong, John 113 Arntzen, Magnus 172 Arora, Mukta 169 B Arrigoni, Giorgio 152 Arrivé, Clémence 249 Babakov, Vladimir 166, 182 Arroyo-Berdugo, Yoana 118 Babalyan, K.A 197 Arroyo, Laura 173 Babu, Mohan 81, 257 Arsenos, George 173 Bache, Nicolai 242, 243 Artigas, Antoni 165 Bache, Nikolai 188, 217 Artyukhov, A. 196 Bachi, Angela 109, 220 Arufe, María 190 Bachmann, Julie 210 Asakura, Masanori 223 Bachs, Oriol 137, 271, 272 Asara, John 257 Bachur, Richard 271 Ashizawa, Kaduho 209 Back, Seunghoon 192 Ashman, Keith 128 Bacsik, Viktoria 110 Ashton, Nicholas 107 Badache, Ali 255 Asif, Abdul 233, 256 Badimon, Lina 221 Assadsangabi, Arash 201 Baek, Je-Hyun 71 Astarita, Giuseppe 156 Baek, Kwang-Hyun 135, 143, 268 Astigarraga, Itziar 208 Baek, Moon-Chang 116 Asumendi, Aintzane 118, 193 Baek, Rikke 140 Athanason, Mark 144 Bae, Kwang-Hee 144 Atkinson, Michael J. 231 Bae, Narkhyun 112 Audebert, Stephane 133, 255 Baessmann, Carsten 50, 128, 246, Audinot, Jean-Nicholas 166 249, 251 Aufricht, Christoph 186 Bafna, V. 31 Augustin, Angélique 255 Bafna, Vineet 31 Aust, Daniela 124 Baharvand, Hossein 137, 139 Auwerx, Johan 58 Bahrani, Farideh 208 Avolio, Alberto 133 Bairoch, A. 54 Axmann, Ilka 113 Baiwir, Dominique 106, 159, 198, 244 Ayala, Mario Nuño 184 Baker, M. 61 Ayers, Deb 122 Baker, Mark 7, 8, 65, 75, 98, 99, 114, Aye, Thin Thin 150 133, 260 Ayi, Irene 104 Baker, Mark S 105 Ayllón, Nieves 253 Baker, Ysobel 38 Ayoglu, Burcu 55, 103 Baldan-Martin, Montserrat 139, 221, 222, Ayuso, Ángel 125 223 Azarkin, Igor 131 Baldassarre, Angela Di 234
300 Baldetorp, Bo 126, 131 Bassas, Abdulelah 144 Ballescà, Josep Lluís 271 Bassols, Anna 173 Balluff, Benjamin 246 Basta-Kaim, Agnieszka 235 Balyasnikova, Irina V 101 Bastos, Viviane 188 Bandhakavi, Sricharan 181, 215, 216 Basu, Mahashweta 228 Bandrowski, Anita 74 Batalha, Iris L. 151 Banerjee, Sudeshna 155 Bathon, Joan 247 Bange, Tanja 134 Batlle, Raquel 100 Bang, Joo Young 71 Baudelet, Emilie 133, 255 Bantscheff, Marcus 241, 255, 267 Baugher, April 181 Bányai, István 161 Baumann, Christian 106, 158 Barallobre-Barreiro, Javier 227 Bausch-Fluck, Damaris 268 Barau, Caroline 247 Bayés, Àlex 55 Bárbara, Cristina 168 Bazán-Méndez, César I. 120 Barbhuiya, Mustafa 193 Bazene, Chantal 107 Barbhuiya, Mustafa A. 121 Bazenet, Chantal 159 Barbier, Pascale 184 Bazylak, Grzegorz 146, 184 Barboro, Paola 218 Beaskoetxea, Javier 265 Barbosa, José 206, 238 Beau-Larvor, Charlotte 249 Barceló, Silvia 271, 272 Becher, François 237 Barderas, Maria G. 139, 221, 222, Béchet, Daniel 155 223, 231, 239 Bech, Joan Josep 160 Barderas, María G. 140 Bech-Serra, Joan-Josep 128 Barderas, Rodrigo 100 Beck, Alain 188, 249 Barile, Daniela 190 Becker, Kristin 225 Barreiro, Carlos 192, 193 Becker, Michael 250, 261 Barrera-Pacheco, Alberto 146, 171 Becker-Pauly, Christoph 136 Barreton, Gustavo 124 Beck, Florian 224 Barrio-Hernandez, Iñigo 134, 135 Beck, Hans C. 226 Barr, John 222 Beckmann, Janine 250 Barros, Lorena 171 Beck, Scarlet 246 Barroso, Albert 206 Beekhof, Robin 153 Barroso, Eduardo 251 Beenstock, Jonah 151 Barroso, Gemma 173, 231 Belgacem, Omar 184 Barsnes, Harald 124 Belisario, Maria Antonietta 239 Barthe-Dejean, Nicolas 266 Bell, David 99 Barthélemy, Nicolas 237 Bell-Temin, Harris 144, 184 Bartolome, Raquel 108 Beltiukov, Petr 182 Bartolome, Ruben A 101 Beltran-Alvarez, Pedro 133 Bartolomé, Ruben Alvaro 100 Beltrao, Pedro 262 Bartsch, Joerg W. 130 Beltzung, Etienne 265 Barut, Miloš 113, 161, 248 Benabdelkamel, Hicham 144 Bassani-Sternberg, Michal 44 Benavente, Fernando 206, 238
301 Bendixen, E. 45 Bhatt, Anugya 225 Bendixen, Emöke 175 Bhattarai, Sudip 267 Bendixen, Emøke 9, 58, 66, 176 Bhat, Vadiraja B. 244 Benevento, Marco 113 Biagini, Massimiliano 209 Bengtsson, Anders A. 201 Bianchi, Giovanna 105 Benhaim-Delarbre, Margaux 173 Bianchi, Laura 42, 175, 233 Bennett, K.L 110 Bian, Jingfang 270 Bennett, Mark 156 Biçer, Atilla 137 Bennike, Tue 117, 182 Bidaut, Ghislain 133 Bensimon, Ariel 35 Biesen, Wim Van 240 Benvenuto, Eugenio 113 Bigaud, Emilie 148 Benzoubir, Nassima 152 Bihan, Thierry Le 232 Beppu, Minako 216 Bijlsma, Astrid 155 Bérard, Izabel 160, 191 Bileck, Andrea 109, 199, 243 Berchem, Guy 115, 162 Bílková, Zuzana 152 Beretov, Julia 99, 112 Bilova, Tatiana 178 Beretta, Laura 67 Binai, Nadine 242 Berg, Bart H.J. van den 164, 244 Binai, Nadine A. 243 Berg, Bart van den 107, 215, 243, 256 Binek, Aleksandra 184 Berg, Bart Van Den 161 Bini, L. 56, 61 Berger, Francois 251 Bini, Luca 7, 9, 56, 175, 233 Berger, Judith 166, 261 Biniossek, Martin 130 Berger, Walter 109 Biondani, Giulia 108 Bergsten, Peter 72, 148, 268 Biosa, Grazia 172, 210, 253 Bernad, António 226 Birgersson, Elin 223 Bernal, Dolores 139 Birkelund, Svend 117, 182 Bernal, Maria C. 174 Birkler, Rune I.D. 250 Bernhardt, Jörg 211 Birkler, Rune Isak Dupont 186 Bern, Marhsall 263 Bischoff, Rainer 78, 100 Bertaccini, Diego 249, 250 Bischoff, Rainier 78 Bertile, Fabrice 173, 192 Bischof, Julia 161 Bertil, Fabrize 66 Bisser, Sylvie 253 Bertolotto, Antonio 236 Bitterman, Peter 169 Bertrand, Fabre 255 Bize, Pierre 173 Berven, Frode 76 Bizerra, Fernando 174 Berven, Frode S. 272 Björkqvist, Maria 237 Bessant, Conrad 215, 218 Bjørling-Poulsen, Marina 226 Besson, Arnauld 137 Blagoev, Blagoy 134, 135 Beuerman, Roger 165 Blal, Hammou Ait 141 Beuerman, Roger W. 123 Blanco-Colio, Luis 220 Bhamra, Amandeep 218 Blanco, Francisco 47, 190, 200, 271, 272 Bhardwaj, Gourav 225 Blanco, Francisco J 200 Bhargava, Maneesh 169 Blanco, Francisco J. 108, 199
302 Blanco, Francisco. J. 245 Borrebaeck, Carl 127 Blankley, Richard 244 Borrebaeck, Carl A.K. 201 Blankley, Richard T 156 Borthwick, Andy 156 Blank, Michael 93, 187, 188, 217, 263 Bortlíèek, Zbynìk 118 Blasko, Juraj 228 Bortoli, Maida de 124 Blattmann, Peter 31 Bosch, Dario 70 Blender, Josip 75 Bosch, Elena 145 Blennow, Kaj 163, 231, 234 Bosch, Linda JW 131 Blesbois, Elisabeth 176 Bosompem, Kwabena 104 Blobel, Carl 110 Boström, Tove 239 Bloomfield, Nick 240 Bøtker, Hans Erik 148 Blüher, Matthias 147 Botting, Gregory 126 Blum, David 238 Botturi-Cavailles, Karine 191 Blundell, Tom L. 26 Botturi-Cavaillès, Karine 160 Boamah, Daniel 104 Bouamrani, Ali 251 Bodenmiller, Bernd 43, 194 Boucau, Julie 210 Boehm, Gitte 149 Bouchal, Pavel 118 Boersema, Paul 81, 194, 244 Bouchiat, Frederic Dumas 251 Boge, Annegret 216 Bou, Germán 213 Bogle, Orleigh 271 Bouhenni, Rachida 117 Boichenko, Alexander 100 Boukli, Nawal 114, 234 Bomgarden, Ryan 126, 187, 213 Bourgeade, Marie-Françoise 152 Bonacci, Thomas 133 Bourgoin-Voillard, Sandrine 106, 112, 113, Bonaldi, Tiziana 105, 119, 190, 200, 261 150, 160, 191 Bonaldo, Paolo 258 Bourmaud, Adele 216 Bonaventura, Gianni Di 211 Bousquet-Dubouch, Marie-Pierre 255 Bondi, Heather 271 Boutej, Hejer 233 Bongarzone, Italia 124 Bouyssié, David 264, 266 Bongcam-Rudloff, Erik 66 Boyano, Dolores 208 Bonilla, Felix 104 Boyano, María Dolores 118, 193 Bonilla, Leo E 148 Bozza, Fernando 254 Bonizzi, Luigi 176, 187 Bozza, Patricia 254 Bonotti, Alessandra 111 Bracht, Thilo 169 Bonzon-Kulichenko, Elena 191, 220 Braghetta, Paola 258 Bonzón-Kulichenko, Elena 184, 186 Bramwell, David 218 Boocock, David 77, 109 Branca, Rui 159 Borchers, C.H. 48 Brancia, Francesco 242 Borchers, Christoph 251 Brandão, Juliana 174 Borchers, Christoph H 19, 20, 48, 119 Brandes, Hillel 188 Borén, Mats 157, 242 Brandi, Jessica 108 Borg, Jean-Paul 133 Branson, Emma 169 Borner, Georg 139 Branson, Owen E. 163 Borràs, Eva 231 Braschi, Simon 74
303 Brás, Lisandra E. de Castro 120 Buée-Scherrer, Valérie 238 Brauch, Dominic 178 Bueno, Amaia 239 Braun, Nancy 258, 270 Bugrova, Anna 164, 216 Braun, Thomas 146, 192 Bulone, Vincent 141 Bravo, Susana B 145 Bunik, V. 196 Breckels, Lisa 139, 259 Bunya, Masaru 209 Brehmer, Dirk 260 Buratovic, Sonja 231 Breitinger, Ewa 256 Burel, Alexandre 266 Breitkopf, Susanne 257 Burger, Thomas 259 Breitsprecher, Dennis 255 Burgt, Yuri van der 247 Breitwieser, F. P 110 Burillo, Elena 220 Bremang, Michael 190, 261 Burkhardt, Brant 144 Breukelen, Bas 256 Burkhart, Julia 224 Breukelen, Bas van 113, 142, 150, 191 Burkhart, Julia M 224 Brier, Michael 268 Burkhart, Julia M. 225 Brinkmalm, Ann 55, 231 Burkhart, Julia Maria 45 Brinkmalm, Gunnar 231 Burlet-Schiltz, Odile 255, 264 Brito, Catarina 226 Burte, Florence 210 Britton, David 149 Büscher, Philippe 253 Bromiski, Maciej 188 Bushfield, Mark 74 Bronzo, Valerio 187 Bushkin, Gary G. 207 Bross, Peter 186 Busto, Estela Del Castillo 103 Broughton, Marianne N. 127 Butler-Browne, Gillian 155 Brown, Kristy 111 Butscheid, Yulia 161 Brown, Lewis M. 101 Butter, Falk 229 Broxterman, Henk 153 Butt, Yoki Kwok-chu 127 Brugada, Ramon 133 Byram, Gregory 194, 224 Bruinen, Anne 245 Byström, Sanna 103 Bruley, Christophe 266 Brumatti, Gabriela 100 Brummer, Tilman 123 C Brunak, Soeren 183 Brunel, Jean-Michel 184 Caballero-López, Marcos 173 Brunetti, Enrico 253 Caballero-López, Marcos Javier 231 Brunoro, Giselle 128, 254 Cabello-Hurtado, Francisco 177 Brun, Virginie 247, 249 Cabezas-Wallscheid, Nina 196 Bucci, Joseph 99 Cabras, T. 170 Buchkremer, Stephan 235 Cadavid, Veronica 174 Buckland, Michael 104 Caillierez, Raphaelle 238 Buckland, Michael E. 100 Cai, Yan 76, 203, 242 Budhraja, Rohit 169, 182 Cajander, Annelie 269 Budinská, Eva 118 Calamia, Valentina 199, 200, 268 Buée, Luc 237, 238 Calderón-González, Karla G. 120
304 Calimport, Stuart 185 Capitanio, Daniele 258 Calvano, Damiana 232 Capobianco, Marco 236 Calvaruso, Maria Antonietta 270 Capodicasa, Cristina 113 Calvete, J. 62 Cappio, Federico Caligaris 109 Calvete, J. J. 26 Carbone, David P. 163 Calvete, J.J. 60 Carbonell, Elain Gutierrez 176 Calvete, Juan 6 Cardinali, Barbara 160 Calvete, Juanjo 7, 10 Cardoza, Rosa E 193 Calvo, Enrique 31, 221 Cardozo, Karina Helena Morais 224 Camadro, Jean-Michel 194, 248 Carli, Franca 160 Camafeita, Emilio 147, 184, 185, 191, 220 Carli, Mariasole Di 113 Camerini, Serena 139 Carlsen, Thomas 182 Camoin, Luc 133, 209, 255 Carlsohn, Elisabet 272 Campanhon, Isabelle 211 Carlson, Jonathan 210 Campbell, Islay 262 Carney, Tom J. 195 Camp, David G 125 Carpentieri, Andrea 207 Campos, Alex 165 Carpi, Donatella 218 Campos, Francisco 171 Carpintero-Fernandez, Paula 108 Campos, Germán Gutiérrez 211 Carrascal, Montserrat 7, 10, 16, 153, Campos-Sandoval, Jose A. 112 199, 213, 272 Campoy, Irene 128 Carra, Silvia 175 Canals, F. 34, 45 Carreira, Bruno P. 186 Canals, Francesc 125, 128, 160, 251, 271, Carreira, Ricardo 246 272 Carrera, Monica 171, 184, 188 Cañas, Benito 171 Carrondo, Manuel J. 226 Canchaya, Gabriela 110 Carulla, Natàlia 236 Canchaya, Gabriela N.S. 110 Carvalho, Ana S. 168 Canetti, Diana 258 Carvalho, Beatriz 131 Canio, Michele De 176, 187 Carvalho, Caetana M. 186 Cannata-Ortiz, Pablo 140 Carvalho, José 164 Cantley, James 268 Carvalho, Paulo 171, 254 Cantó, Ester 231 Carvalho, Valdemir M. 205 Cantón, Rafa 69 Carvalho, Valdemir Melechco 224 Cantoral, Jesus 174 Casadonte, Rita 124 Cantor, David 98, 99, 105 Casal, I. 30 Canty, John 227 Casal, Ignacio 7, 10, 30, 272 Cao, Cheng-Xi 242 Casal, J Ignacio 101 Cao, Ruifang 126 Casal, J. Ignacio 104, 271, 272 Cao, Weiqian 203, 243 Casal, Jose Ignacio 100 Capasso, Giovambattista 220 Casals, Ignacio 7, 17 Capelo, José 263 Casals-Pascual, Climent 70, 208 Capelo-Martinez, Jose Luis 199 Casanueva, Felipe F 145 Capelo-Martinez, Jose-Luis 212 Casarini, Dulce 174, 205
305 Casas, Vanesa 213 Chang, Chiou Ling 171 Casas, Vanessa 153, 199, 213 Chang, Chuan-Fa 46 Cascante, Marta 112, 113 Chang, Hua-Chien 116 Casella, Maria luisa 139 Chang, Joel 134 Cash, Phillip 222 Chang, Lei 99 Casola, Stefano 190 Chang, Wei-Hung 248 Cassano, Giovanni B. 232 Chang, Wen-Neng 146 Cassidy, Liam 136 Chang, Ying 122 Castagnola, M. 170 Chang, Ying-Hua 116 Castagnola, Massimo 156, 232 Chan, Lawrence C.B. 146 Castanheira, Pedro 164 Chao-Chi 111 Castillo, Judit 271 Chao, Chih-Yun 175 Castro, Ivone 120 Chaoui, Karima 168 Castro, Mariana S. 179 Chapuis, Pierre 114 Catrina, Anca I. 202 Chassaigne, Hubert 218 Caveda, Cira Rosario 129 Chatterjee, Aditi 121, 193 Cecconi, Daniela 108 Chatziharalambous, Despina 158 Ceciliani, Fabrizio 187 Chaurand, Pierre 21 Cegan, Alexander 166 Chawade, Aakash 266 Cela, Rafael 184 Chazigaleeva, R.A 197 Céline, Rivaux 147 Checa-Rojas, Alberto 104 Celorio-Mancera, Maria de la Paz 178 Chen, Bingjie 150 Cerbón, Marco Antonio 111 Chen, Chen 142 Cerciello, Ferdinando 163 Chen, Chien-Sheng 211 Cernigoj, Urh 161, 248 Chen, Chien-Sin 149 Cerrudo, Inmaculada Jorge 184 Cheng, Hai-Ying M. 234 Cesaro, Luca 152 Cheng, Lei 186 Cesar, Valeria Cerqueira 110 Cheng, Pin-Nan 116 Chaerkady, Raghothama 244 Cheng, Shujun 116 Chaffey, Ben 218 Cheng, Zhongyi 133 Chai, Hwa Chia 198 Chen, Hong-Jhang 237 Chakrabarti, Subhabrata 169, 182 Chen, Jiajia 133 Chakraborty, Niranjan 149, 172 Chen, Lingfan 99 Chakraborty, Subhra 149, 172 Chen, Lu 116, 134 Chalifa-Caspi, Vered 177 Chen, Rui 194, 195 Chambers, Andrew 68, 251 Chen, Shu-Hui 149 Chambon, Christophe 155 Chen, Wei 248, 251 Champagnon, Isabele 212 Chen, Wei-Jung 175 Chan, Charles 114 Chen, Wei-Qiang 113, 158, 161, 248 Chan, Choi Mun 165 Chen, Yet-Ran 237, 248 Chan, Daniel 75 Chen, Yi-Lin 175 Chan, Daniel W. 61 Chen, Yue 119 Chandramouli, Kondethimmanahalli 37 Chen, Yu-Ju 139, 149, 151, 232
306 Chen, Zhuchu 112 Chua, Kek Heng 198 Cheon, Mi Hee 102 Chuan, Chiang-Ni 212 Chernjavski, Alexandr 220 Chung, Cheng-Han 149 Cheruku, Harish 98, 99, 105 Chung, Hyewon 70, 71 Chesi, Giancarlo 258 Chung, Ky Hyun 111, 126 Chiang, Cheng-Kang 234 Chung, Maxey C.M. 8 Chiappe, Diego 121 Chung, Maxey CM 126 Chiappetta, Gennaro 185 Chung, M. C.M. 46 Chiappetta, Giovanni 185, 186 Chung, Raymond 159 Chiara, Lavarello 180 Chung, Young-Ho 173, 177, 178 Chiasserini, D. 141 Chun, Ka Man 150 Chinea, Angel 234 Cianférani, Sarah 188, 218 Ching, Arthur Kar Keung 127 Ciborowski, Pawel 140, 195 Chiocca, Susanna 105 Cibulka, Jan 181 Chiurazzi, Pietro 232 Cicchittti, Sandra 164 Chiva, Cristina 103, 231 Cifani, Paolo 257 Choi, Ae Jin 71 Cillero-Pastor, Berta 245 Choi, Bum-Chae 143 Ciniselli, Chiara M. 124 Choi, Chi Won 138 Ciregia, Federica 81, 111, 232 Choi, In Soo 171 Cizkova, Dasa 228 Choi, Jong Min 117 Clare 77 Choi, Jung Ha 178 Clarke, Candice 114 Choi, Manbok 201 Claude, Emmanuelle 240 Choi, Meena 231 Claussnitzer, Melina 147 Choi, Moonhwan 152 Claustre, Johanna 160, 191 Cho, Je-Yoel 163 Clec’h, Celine Le 251 Cho, Jin-Young 268, 269 Clémence, Arrivé 147 Chokchaichamnankit, Daranee 103 Clemente, Felipe 272 Cho, Kun 178 Clements, Judith 130 Choong, Lee Yee 101 Clermont, Allen 71 Choudhary, Jyoti S. 262 Clevers, Hans 77, 110 Choudhary, Pooja 149 Clifton-Bligh, Roderick 114 Chowdhury, Azazul 148 Clish, Clary B. 101 Cho, William C 132 Cloos, Jacqueline 154 Chow, Lu-Ping 111 Cocco, Tiziana 232 Cho, Yoon Sun 196 Codina, Montserrat 271 Chretien, Michel 226 Codreanu, Simona G. 163 Christelle, Gateau 147 Coelho, Ana Varela 177, 178, 214 Christensen, Gunna 117 Colacios, Céline 181 Christophe, Bruley 147 Colangelo, Christopher M. 157 Christopherson, Richard 104 Colás, Eva 128 Christopherson, Richard I. 100, 104, 123 Cole, Robert N 244 Chua, Ignatius 165 Colinge, J. 110
307 Collins, Andrew 215 costa, Gonçalo Da 251 Collins, Ben 156 Costantino, Paolo 209 Collins, Ben C 250 Costello, Catherine 8, 58, 69, 79 Collins, Peter W 224 Costello, Catherine E 207 Colomé-Calls, Núria 128, 251 Costello, Eithne 108 Colomé, Nuria 272 Cotelli, Franco 175 Colon, Maricarmen 114 Cottrell, John 14, 15 Colzani, Mara 179 Cotugno, Roberta 239 Comabella, Manuel 231 Coucke, Wim 240 Cominetti, Ornella 144 Coudy, Cecile 155 Concha, Gil 214 Couté, Yohann 138, 218 Concilli, Mafalda 258 Couto, Natacha 214 Connell, James J. 252 Couture, Jean-Francois 136 Connolly, Joanne 201 Covas, Dimas 110 Consortium, UniProt 264 Coveney, Clare 77, 109 Conte, Ianina 210 Cox, Juergen 15, 153, 246 Contreras, Stephanie 190 Cox, Jurgen 14 Coombes, Kevin R 163 Cozzi, Paul 99 Cooper, Garth JS 156 Cozzolino, Flora 258 Cooper, Jonathan 151, 246 Craig 70 Coorssen, Jens 270 Craig, Colleen 195 Corbí, Ángel Luis 214 Cremer, Koen De 240 Cordeiro, Carlos 251 Crescenzi, Marco 139 Cordier, Stéphane 177 Crèvecoeur, Inne 183 Corfe, Bernard 201 Criado, Ignacio 108 Cormio, Antonella 270 Criado, Lourdes 173 Cornett, Shannon 167 Cristaudo, Alfonso 111 Cornish, Virginia W. 101 Cristea, I. 48 Corona, Fernando 213 Cristea, Ileana 48, 69 Corpillo, Davide 175, 236 Cristiano, Garino 175 Corrales, F. 131 Cristina, Bottino 180 Corrales, Fernando 272 Cristobal, Alba 77, 110, 142, 243 Corrales, Fernando J 67 Cristóbal, Carmen 221 Corrales, Fernando J. 6, 7, 10, 67, 148, Crosbie, Phillip 106 187, 271, 272 Crossett, Ben 104, 123 Corrales, F. J. 26 Crouch, Michael 99 Corrales, F.J 36, 62 Csordas, Attila 262 Cortés, Roldán 112, 113 Csosz, Eva 110, 160 Corthals, G. 45 Csutak, Adrienne 160 Corthals, Garry 7, 9, 77, 182 Cubano, Luis 114, 234 Corthésy, John 144, 177 Cubeddu, Tiziana 139, 210 Cosemans, Judith M.E.M 224 Cubedo, Judit 221 Cosette, P. 202 Cuccurullo, Manuela 229, 238
308 Cuda, Giovanni 122, 159, 210 D´Avola, D. 131 Cuello, Friederike 168 Dayon, Loïc 65, 72, 138, 144, 177 Cuesta, Fernando de la 140, 221, 222, Debaene, François 188 223, 239 Decastelli, Lucia 175 Cuesta, Fernando De La 139, 221 Decoux, Ashley 222 Cui, Chunping 117 Deeg, Cornelia A 71 Cuijpers, Sabine 134 Deeke, Shelley 201 Cunha, Raquel 226 Degano, Rosa Mª 217 Cunha, Tatiana 205 Degos, Vincent 157 Cunningham, Robert 213, 217 Degtyarev, Dmitriy 164 Cuomo, Alessandro 119, 261 Deineko, Viktor 257 Cuppen, Edwin 142 Dekker, Lennard 100, 220 Curto, Miguel 205 Delanghe, Bernard 263 Cury, Patrícia 122 DeLeon-Pennell, Kristine Y. 120 Cutak, Ben 99 Delfani, Payam 201 Cutillas, Pedro 49, 151 Delgadillo-Silva, Luis-Fernando 104 Deligios, Massimo 210 Dell, Anne 205 D dell’Orco, Francesca 173 Delvenne, Philippe 106, 159 Daali, Youssef 241 Demelia, L. 170 Dai, Jie 136 Demenkov, Pavel 257 Dalebout, Hans 247 Demey-Thomas, Emmanuelle 247 Dallas, Dave 190 Demianova, Zuzana 129, 251 D´Amato, A. 169, 178 Dempsey, Nora 251 D’Amato, Alfonsina 179 Denekamp, Nadav 177 Damholt, Zacharias 166 Deng, chunhui 134 D’Amico, Maria Angela 234 Deng, Chunhui 134 Dammeier, Sascha 70 Dengjel, Joern 123 Dando, Ilaria 108 Dengjel, Jörn 134 Dang, Liuyi 204 Dent, Owen 114 Danielsson, Frida 141 Depke, Maren 211 Dantas, Patricia 174 Deramecourt, Vincent 238 Daou, Pascale 255 Dermody, Jessica 216 Darde, Verónica M. 172, 173 Deustch, E. 57 Darebna, Petra 205 Deutsch, Eric 12, 65, 73, 74 Dariolli, Rafael 224 Deutsch, Eric W 213 Dasilva, Gabriel 184 Deutsch, Eric W. 264 Datta, Keshava 193 Devaux, Stéphanie 228 Datta, Susmita 268 Devis, Laura 128 Dauly, Claire 168 Dey, Sanjoy 169 Davalieva, Katarina 114, 163 D’Hertog, Wannes 183 Davies, Tom 181 Dhople, Vishnu 225
309 Dhople, Vishnu Mukund 161, 215 Dorfer, Viktoria 263 Diamandis, Eleftherios 246 Dörrbaum, Aline R 251 Díaz, Berta 128 Dörr, Marcus 225 Díaz-Gois, Agustín 146 Dorsselaer, Alain Van 173, 188, 192, Diaz-Lobo, Mireia 189 249, 250 Diaz, Manuel Nieto 172 Dorsselaer, Dr. Alain Van 87 Díaz, Ramón 165 Dousová, Katerina 196 Díaz, Verónica 254 Dowsey, Andrew 215, 262 Dichgans, Martin 256 Drabovich, Andrei 35, 246 Diedrich, Britta 123 Dracup, Will 218 Diehl, Hanna C. 119 Drake, Richard R. 160 Dietz, Katharina 183 Dreher, Wolfgang 166 Diez-Masa, Jose C. 203 Drepper, Carsten 229 Diez, Paula 108, 217 Drews, Oliver 249 Dijon, Sophie 195, 201 Dreyfus, Matthieu 251 Dikler, Sergei 125, 167 Drici, Lylia 134 Dillon, Gary 74 Drobin, Kimi 103, 119, 223 Ding, Chen 49, 146, 181 Droste, Jochim S Terhaar Sive 131 Dingemans, Milou M. L. 158 Druker, Brian 101 Distler, Ute 127, 263, 264 D’Silva, Arlene 270 Dive, Caroline 106 D’souza, Rochelle 134 Dobi, Albert 125 Dubois, Marc 264, 266 Dobrohotov, Igor 269 Dubrovsky, Yaroslav 166, 182 Dobrokhotov, Igor 269 Duernberger, Gerhard 265 Doherty, Darren 113 Dufresne, Craig 70, 117 Doherty, Mary 43, 56, 222 Dufresne, Craig P. 184 Dojahn, Joerg 50, 240 Duguet, Fanny 181 Doll, Andreas 103 Duhamel, Marie 180 Döll, Stefanie 172 Duits, Floor 231 Domasinska, Petra 166 Duncan, Mark W 144 Domingo, Jaime Santo 138 Dunning-Foreman, Naomi 77, 109 Domingo-Prim, Judit 116 Dunn, Michael J. 54 Do, Misol 162 Dupierris, Véronique 266 Domon, B. 55 Duran, Carmen 205 Domon, Bruno 8, 56, 68, 115, 128, 162, Duran, Mª Carmen 227 216 Durighello, Emie 247 Domont, Gilberto 171 Dürnberger, Gerhard 263 Domont, Gilberto B. 135 Dutta, Bamaprasad 122 Donadio, Carlo 267 Dvoøáková, Monika 118 Donadio, Elena 111, 232 Donini, Marcello 113 Donnarumma, Danilo 209 Dopazo, Ana 125 E
310 Emele, Felix 256 Early, Michael 215 Emili, Andrew 152 Eberle, Andrea B. 116 Enany, Shymaa 208 Eberl, H. Christian 255 Encarnación-Guevara, Sergio 104 Eberlin, Livia 21 Endt, Kathrin 107 Eble, Johannes A. 182 Engelberg, David 151 Ebrahimi, Maryam 165 Engeler, Daniel 107 Eckey, Maren 157 Engelken, Johannes 145 Eckhardt, Adam 191, 196, 198 Eng, Jimmy K. 264 Eckler, Larry 157 Enyaru, John 253 Edbauer, Dieter 229 Eperon, Simone 168 Eddarkaoui, Sabiha 238 Epifanio, Vera L. 110 Eddes, James 241 Eriksson, Per 231 Edfors, Fredrik 159, 239 Erlinge, David 226 Edgar, James 139 Erramuzpe, Asier 193 Edhager, Anders V. 148 Escalante, Teresa 188 Edmonds, Donna 18, 20 Escobar, Ana Gallardo 172 Edward, Deepak 117 Escobedo-Ríos, David 211 Edwards, Alistair 33 Escobes, Iraide 157, 239 Edwin, De Pauw 106 Escobés, Iraide 105 Eggeling, Ferdinand von 21 Esdar, Christina 122 Eifler, Karolin 134 Esnault, Marie-Andrée 177 EijKel, Gert 245 Espadas, Guadalupe 145 Eijsink, Vincent 172 Espinosa, Nadia Luz López 211 Eisenacher, Martin 236 Estanyol, Josep M. 271 Ejido, Jesús 220 Estanyol, Josep Mª 271, 272 Ekert, Paul 100 Estanyol, Josep Maria 271 Eklund, Anders 202 Estanyol, Josep María 137 Ekström-Smedby, Karin 119 Esteso, Maria Jose Martinez 33 Elagamey, Eman 149 Esteve, C. 178 Elamin, Ashraf 195, 201 Eun, Park Kyoung 273 Elbaek, Anne 140 Evans, Amanda 169 Eleuterio, Enrica 164, 211, 234 Evans, Caroline 201 Elia, Laura 122 Everett, Allen 19, 82 Elisabeth, Mintz 147 Evers, Waltraud 249 Eliuk, Shannon 245 Eyckerman, Sven 257 Elliott, Victoria 108 Eyk, Jennifer E. Van 70 Elortza, F. 32 Eyk, Jennifer Van 7, 17, 20, 54, 58, 79, 217, Elortza, Felix 67, 105, 157, 208, 239, 247 272 Elortza, Félix 271 Elvira, Inglese 180 F Emdal, Kristina B. 38
311 Faa, G. 170 Feldman, Daniel R. 125 Faca, Vitor 110 Feliciano, Amelia 168 Faça, Vitor M. 110 Felipo, Vicente 158 Faerber, Franz 267 Felix, Stephan 225 Fafián, Juan 190 Fenaille, François 237 Fagerberg, Linn 191 Feneberg, Emily 140 Falcon-Perez, Juan M 32 Feng, Yuehan 244 Falkenby, Lasse G 244 Fenselau, Catherine 33 Fälth-Savitski, Maria 241 Fenton, Robert A. 186 Falvo, Sara 236 Fenyo, D. 43 Fan, Chao 245 Fenyö, David 272 Fan, Fengxu 117 Fera, Maria 110 Fang, Pan 114 Ferlini, Alessandra 258 Fang, Wang 135 Fernandez-Acero, Francisco J. 174 Fan, Huizhi 134 Fernández-Aguado, Marta 192 Fani, Mohammad Mehdi 208 Fernández, Carolina 199 Fan, Jun 215, 218 Fernandez-Costa, Carolina 199 Fan, Liu-Yin 242 Fernández-Costa, Carolina 199, 200, 268 Fanni, D. 170 Fernandez-Irigoyen, Joaquin 235, 269 Faria, Tiago 164 Fernández, Joaquín 272 Farina-Gomez, Noemi 203 Fernández, Pablo 190 Farinha, Ana P. 152 Fernández, Patricia 272 Farinha, Ana Paula 42 Fernandez-Ponce, Cecilia 227 Farnsworth, Charles 130 Fernandez-Puente, Patricia 108, 199 Farré, Isabelle 122 Fernández-Puente, Patricia 199, 200 Farrokhi, Hamid Reza 209 Fernandez-Reyes, Delmiro 210 Fasano, Mauro 81, 229, 238, 271 Fernandez-Suarez, Rocio 193 Faserl, Klaus 173 Fernandez-Tajes, Juan 199 Fasoil, E. 178 Ferreira, Alexandre 107 Fasoli, E. 169 Ferreira, Dennis 211 Fasoli, Elisa 179 Ferrer, Daniel Lopez 217 Fatahi, Faranak 137 Ferrer, Isidro 165 Fathi, Ali 137 Ferrer, Ricard 165 Fatou, Benoit 122 Ferretta, Anna 232 Fava, Marika 227 Ferrigno, Paul Ko 169 F.Blanco 47 Ferri, Sara 70 Feener, Edward P. 71 Ferro, Myriam 37, 247 Fehm, Tanja 256 Fertig, Alison R. 184 Fehniger, Thomas 126 Fesenko, I.A 197 Fehniger, Thomas E 252 Fichtenabum, Andreas 158 Fehniger, Thomas E. 252, 272 Fichtenbaum, Andreas 106, 161 Fehniger, Tom 78 Fickweiler, Ward 71 Feilitzen, Kalle von 74 Figeys, Daniel 136, 194, 201, 226, 234
312 Figueiredo, Andreia 177 Frank, Ronald 98 Fihman, Galina 258 Frank, Schmidt 69 Filiou, Michaela 156, 218, 236 Frantzi, Maria 118 Filipovski, Vanja 114, 163 Franz, Thomas 217 Fillmore, Thomas L 125 Franz-Wachtel, Mirita 273 Filomena, Angela 262 Fraselle, Stéphanie 240 Finamore, Francesco 47 Fraumene, Cristina 210 Finjeman, Remond 129 Fredericksson, Simon 65 Fischer, Martina 264 Fredolini, Claudia 103, 119, 159 Fischer, Sven 140 Fredriksson, Simon 65 Fisher, Christal 156 Freitas, Michael A. 163 Fisher, Shannon 175 Frewen, Barbara 224 Flamant-Waret, Hélène 160, 191 Fricke, Anna Lena 135 Flately, Brian 113 Friedrich, Katrin 124 Fletcher, John S. 21 Friguet, Bertrand 123 Fletcher, Julie 114 Frisch, Christian 181 Flier, Wiesje M. van der 231 Froehlich, Sophie 128 Flowers, Sarah A. 203 Frolov, Andrej 147, 178 Flynn, Elizabeth 222 Frutos, Mercedes de 203 Focà, Alfredo 210 Fthenakis, George 173 Foddis, Rudy 111 Fucikova, Alena 156 Foltz, Kathy 152 Fuente, Ildefonso de la 193 Ford, Rhian-Marie 145 Fuente, José de la 253 Forlino, Antonella 175 Fuentes, Isaac 190 Forsström, Björn 234, 239 Fuentes, M. 55 Fortes, Claudia 146 Fuentes, Manuel 69, 108, 199, 217, 271, Fortino, Vittorio 182 272 Fortuin, Suereta 149 Fuessel, Susanne 119 Fortún, Jesús 69 Fujinaka, Hidehiko 136, 150 Fouda, Catherine 167 Fujinawa, Reiko 204 Fournier, Isabelle 56, 122, 165, 180, 228 Fujio, Yasushi 220, 235 Fox, Howard 140, 141, 195 Fujita, Mika 206 Fox, Jay W 170 Fukamizu, Kazuna 138, 149 Fox, Jay W. 179 Fung, Shane 263 Fraisier, Christophe 209 Funke, Sebastian 160 Francavilla, Chiara 135 Fu, Qin 217, 247 Francesca, Bellora 180 Furmonaviciene, Ruta 181 Franceschi, Giorgia De 244 Fürst, Dieter O. 135 Francesco, Piergustavo De 164 Fu, Tianyi 146 Franchin, Cinzia 152 Fu, Zongming 55 Franck, Julien 165, 228 Franco, Brunella 258 G Franklin, Sarah 225
313 Gabelle, Audrey 237 García, Carlos 200 Gabriele, Caterina 122, 159 García, Concha 212 Gadaleta, Maria Nicola 270 García-Cozar, Francisco 227 Gadher, Suresh Jivan 228 García-Cózar, Francisco 205 Gagliardi, Assunta 175, 233 Garcia, Fernando 30 Gago-Fuentes, Raquel 108 García, Gemma Barroso 172 Gaisa, Nadine T 119 Garcia-Marques, Fernando 42, 191 Galano, Eugenio 174 Garcia, M.C 178 Galdeano, Teresa Muñoz De 172 García-Muñoz, Sara 171 Galiano, Alicia 139 Garcia-Obregon, Susana 208 Galicia, Norma Angélica 120 Garcia-Palmero, Irene 101, 104 Galindo, Antonio Núñez 138, 144, 177 García-Palmero, Irene 272 Galindo, Ruth C. 253 García-Santos, Eva 147, 185 Gallardo-Aguilar, Ana 231 Garcia-Vedrenne, Ana Elisa 152 Gallardo-Escobar, Ana 173 Gardeazabal, Jesús 193 Gallardo, Jose M 171 Gardner, Michael 222 Gallardo, Jose Manuel 188 Garg, Gagan 260 Gallardo, José Manuel 184 Garg, K. 110 Gallardo, Oscar 153 Garin, Jérôme 218, 266 Gallastegui, Edurne 137 Garrido-Medina, Raul 203 Gall, Caroline Le 163 Garrigues, Luc 255 Gallegos-Pérez, José L 120 Gaspari, Marco 122, 159, 210 Gallien, Sebastien 115, 162, 216 Gasparre, Giuseppe 270 Galli, Joakim 248 Gatto, Laurent 80, 139, 259 Gall, Sylvie Le 213 Gautier, Violette 227 Gamer, Martin 164, 215, 244 Gay, Marina 189, 236 Gámez-Pozo, Angelo 30 Geary, Bethany 222 Gandhi, Mayuri 115 Gebhardt, Christoph 249 Gang, Liu 245 Ge, Feng 32 Ganna, Andrea 223 Geisler, Cordelia 119 Gao, Huiying 117 Gelfi, Cecilia 258 Gao, Jifang 235 Gencapo, Hngp 122 Gao, Junjun 255 Georgantzopoulou, Anastasia 166 Gao, Yanning 116 George, Iniga S 172 Gao, Youhe 165, 175 German, Bruce 190 Garbis, Spiros D. 118 Gerner, Christopher 109, 243 García, A. 46 Gerrit, Fijneman 131 Garcia, Alberto Peláez 100 Gesellchen, Frank 151, 246 García, Ana B 227 Gethings, Lee 56, 229, 238, 259 García, Ángel 7, 10, 140, 182, 225 Gevaert, Kris 257, 260 García-Berrocoso, Teresa 160 Ghadiri, pooria 230 García-Calvo, Laura 192 Ghadiri, Pooria 102, 180, 200, 208, 209, Garcia, Camille 194, 248 229, 230
314 Ghantasala, Saicharan 233 Goldring, Christopher 194 Gharbi, Severine 125, 183, 272 Gollapalli, Kishore 115, 233 Gharesi-Fard, Behrouz 267 Golling, Sabrina 255 Ghazizadeh, Zaniar 137 Golzar, Tahereh 208 Ghinassi, Barbara 234 Gombik, Katarzyna 235 Ghisaura, Stefania 139 Gomes-Alves, Patrícia 226 Gholami, Amin Moghaddas 267 Gomes, Catarina 107 Ghosh, Sudip 172 Gomes, Leonardo 211 Giampietro, Antonella 156 Gomes-Neto, Francisco 188 Giangrande, Chiara 204 Gomez-Auli, Alejandro 131 Giannaccini, Gino 111, 232 Gómez-Cardona, Erik Elvin 146 Giansanti, Piero 142, 150 Gomez, Francisco-Jose Fernandez 238 Gibb, Sebastian 259 Gómez-Reino, Juan José 198 Gidlöf, Olof 226 Gómez-Serrano, María 147, 185 Gil, Antonio 128 Goncalves, Emanuel 167 Gil, C. 26, 62 Gonçalves, Lorena 211 Gil, Concha 6, 7, 10, 69, 141, 212, Gonçalves, Lorena Da Ros 212 213, 214, 271, 272 Gonnelli, Giulia 32 Gil de Bona, Ana 48, 213 González-Álvaro, Isidoro 198 Gil-Dones, Felix 231 González, Antonio 198 Gillessen, Silke 107 González-Barderas, M. 271 Gillet, Ludovic 156 Gonzalez-Calero, Laura 140, 222, 223, Gil-Moreno, Antonio 128 246 Gilquin, Benoit 247 González-Calero, Laura 139 Giménez, Belén Gómez 158 González, Carmen 125 Giménez, Estela 206, 238 Gonzalez-de-Peredo, Anne 168 Giner, Pilar 138 Gonzalez, Faviel 215, 262 Gingras, Anne-Claude 46, 91 Gonzalez-Gonzalez, María 272 Gioia, Roberta 175 Gonzalez, Marco 108 Gioria, Sabrina 218 Gonzalez, Marcos 108 Girotti, Albert W. W. 101 González-Márquez, Humberto 120 Giuffre, Robert 244 Gonzalez-Martin, Carmen 145 Giuffrida, Maria Gabriella 175 Gonzalez, Monica 203 Giuseppe, Fabrizio Di 164, 211, 234 Gonzalez-Muñoz, Maria 217 Giusti, Laura 111, 232 Goodchild, Ann 137 Glimelius, Bengt 119 Goode, Bruce L 255 Glorieux, Griet 240 Goodlett, David 161 Goan, Yih-Gang 116 Goodwin, Richard 242 Gobom, Johan 55, 163, 234 Goonatilleke, Elisha 190 Goepel, Wolfgang 164, 244 Goo, Y.A. 72 Goepfert, Jens 107, 129 Goo, Young Ah 161 Góis-Filho, José F. 122 Gopichandran 98 Golatowski, Claas 215 Goracci, Martina 232
315 Goran, Mitulovic 106 Grundner-Culemann, Kathrin 130 Göransson, Charlotta 157 Grunewald, Johan 202 Gorczak, Katarzyna 169 Grus, Franz 70, 160 Gorse, Alain-Dominque 260 Gstaiger, Matthias 59 Gorshkov, Mikhail 158, 248 Guan, Yuanfang 142 Gorshkov, Mikhail V. 101, 262 Guardavacarro, Daniele 256 Goto-Silva, Livia 135 Gudmundsdottir, Valborg 183 Govorukhina, Nathalia 100 Guerra, Paula Fernandez 186 Govorun, Vadim 131 Guerreiro, Ana 113 Govorun, V.M 197 Guerrero, Andres 261 Gowda, Harsha 121, 193 Gueugneau, Marine 155 Graaf, Erik L De 197 Guglielmi, Giovanni 111 Graciá, Maria De Los Angeles 168 GuhaMazumder, Deebendranath 155 Graessel, Anke 183 Gu, Hongbo 130 Graham, Peter 99, 112 Guignard, Cedric 166 Grajales-Lagunes, Alicia 171 Guisa-Hohenstein, Fernando 120 Grajeda, Juan Pablo Reyes 211 Guitián, Esteban 182 Gramolini, Anthony 226 Gunaratne, Jayantha 195 Grande, Giuseppe 156 Gunness, Patrina 146 Granjeaud, Samuel 209 Guo, BP-Chen 232 Grant, Seth G. N. 232 Guo, Chen-Gang 242 Grãos, Mário 164, 257 Guo, Feifei 142 Grasseau, Isabelle 176 Guo, Gaigai 146 Grasset, Fabien 177 Guo, Hongbo 152 Grassi, Mariana 110 Guo, Lin 136 Grassi, Mariana Lopes 110 Guo, Tiannan 30, 167, 250 Grassi, Paola 205 Guo, Tianyao 150 Grateau, Gilles 247 Gu, Peiming 251 Greco, Dario 182 Gupta, Shabarni 162 Greco, Viviana 77, 187 Guruceaga, Elizabeth 272 Gregersen, Niels 186, 250 Guryev, Victor 142 Greifenhagen, Uta 147 Gustafsson, Johan OR 241 Grieken, Nicole C.T. Van 153 Gutiérrez, Lola 213 Grigorian-Shamagian, Lilian 140 Gutiérrez-Ortega, Abel 102 Grinberg, Lea T. 76, 236 Gutiérrez, Santiago 193 Griss, J. 110 Gutleb, Arno 166 Griss, Johannes 49 Güzel, Coskun 100, 220 Grolimund, Larissa 121 Guzzoni, Vinicius 174 Gronemeyer, Thomas 140 Grössl, Michael 109 Grossmann, Jonas 146 Grote, Eric 217 H Gruenbaum, Lore 255
316 Haas, Petra de 212 Han, Meimei 118 Haas, Richard R. De 153 Hanneken, Marina 240 Haastert, Elise van 237 Hannes, Röst 48 Habel, Jeff 216 Hanrahan, Sarah 218 Habuka, Masato 191, 215 Hansen, Maria L. 226 Haddad, Iman 185, 256 Han, Seong Kyu 195 Haddad, Simone Kashima 110 Hansson, Jenny 196 Haertel, Christoph 244 Hansson, Karl 234 Haeussler, Ragna 255 Hansson, Oskar 237 Hager, Jörg 144 Haojie, Lu 204 Hägglund, Per 166, 167 Hao, Jingli 99 Häggmark, Anna 234 Hardouin, J. 202 Haghdoost, Navid 126 Harichaux, Grégoire 176 Hahlbrock, Jennifer 127, 263 Harms, Manuela 183 Hahne, Hannes 157, 267 Harteneck, Christian 101 Hainard, Alexandre 160, 167, 168, 253 Hartmer, Ralf 249 Hakk, Ísmail 179 Hasanabadi, Nazila 200 Halim, Adnan 206 Hasan, Beena 256 Hallingstrom, Maria 166 Hasan, Salma 255 Hallström, Björn 191 Hashiguchi, kazunari 138 Halvorsen, Trine G 127 Hashiguchi, Kazunari 149 Halvorsen, Trine Grønhaug 138 Hashimoto, Yuuki 138 Hamdane, Malika 238 hassanabadi, Nazila 102, 230 Hamedani, Mehrad 168 Hassanabadi, Nazila 102, 180, 209, Hamelin, Romain 121 229, 230 Hammer, Elke 161, 215, 225 Hathout, Yetrib 111 Hammer, Helen 107, 161, 243 Hauberg-Lotte, Lena 166, 261 Hammond, Matt 181, 258 Hauck, Stefanie 147, 183 Hammond, Matthew 270 Hauner, Hans 147 Hamsten, Marica 269 Havelund, Jesper F. 250 Hanash, S. 34 Haverland, Nicole 195 Hanash, Sam 34, 75 Hawkins, Steven 268 Han, Chia-Li 139 Hayes, Catherine A. 205 Hancock, Bill 7, 58, 65, 75 Haynes, Paul 137 Hancock, William 8 Haynes, Paul A 172 Hancock, William S. 269 Ha, Yungeun 152 Hancock, William Stephen 269 Hazenberg, Bouke 81 Handa, Osamu 145 Heazlewood, Joshua 263 Haney, Paul 129 Heck, Albert 16, 30, 61, 77, 113, 142, Hanf, Benedikt 265 242 Hanhineva, Kati 171 Heck, Albert J. R. 150 Hanisch, Franz-Georg 103 Heck, Albert J.R. 110, 191, 243, 256 Han, Jin 185, 223 Heck, Albert JR 227
317 Heckerman, David 210 Hesse, Anne-Marie 218 Heck, J.R. 197 Heubach, Yvonne 256 Heemskerk, Johan W. 224 Heuclin, C. 202 Heemskerk, Johan W.M 224 Heumann, Hermann 228 Heeren, Ron 21 Heumann, Rolf 228 Heeren, Ron M. A. 245 Heusel, Moritz 250 Heesch, Sebastiaan van 142 Hickman, Graham 77, 109 Heffeter, Petra 109 Hiemstra, Annemieke C 131 He, Fuchu 34, 142, 151, 181, 245 Higashimura, Yasuki 145 Heidari-Keshel, Saeed 165 Higashisaka, Kazuma 101, 220, 235 Heidelberger, Sibylle 77, 109, 242 Hilary, Serene 225 Heidenreich, Axel 119 Hildonen, Siri 138 Heidrich, Luzia 108 Hintzen, Rogier 209, 237 Hein, Marco 139 Hirayama, Mio 126 Heinsen, Helmut 236 Hirst, Jennifer 139 Heinzle, Elmar 192 Hirtz, Christophe 237 He, Jintang 125 Hjalgrim, Hendrik 119 Heldmann, Stefan 261 Hjelmare, Martin 141 Helenius, Katja 257 Hober, Sophia 74, 272 He, Mian 127 Hochgräfe, Falko 183 Hendriks, Ivo 134 Hochstrasser, Denis F 241 Henjes, Frauke 103, 119, 159 Hoelper, Soraya 146 Henkel, Corinna 119 Hoeng, Julia 195, 201 Henningsen, Kim 237 Hoffmann, Claudia 129 Henriksen, Kim 166 Hoffmann, Jules 256 Hensler, Sabine 129 Hoffmann, Lucien 166 Hensvold, Aase Haj 202 Hoffmann, Peter 241 Herget, Jan 198 Hoffmann, Ralf 147, 210 Hermjakob, H. 59 Hoheisel, Jörg 32, 108 Hermjakob, Henning 59, 73, 74, 80, Hoheisel, Jörg D 98 215, 217, 262 Ho, Jenny 177 Hernáez, María L. 272 Holden, Sean 139 Hernaez, Maria Luisa 213, 214 Hollema, Harry 100 Hernáez, María Luisa 272 Holm, Anders 108 Hernández-Domínguez, Eric Edmundo 146 Holmes, Christina 271 Hernández-Guillamón, Mar 160 Holmskov, Uffe 169 Hernández-Gutiérrez, Rodolfo 102 Hölper, Soraya 192 Hernández, José M 120 Holst§, Stephanie 46 Hernansanz-Agustín, Pablo 186 Holtfreter, Birte 161 Herrera-Aguirre, María E. 120 Hölttä, Mikko 163, 234 Herrera, Mercedes 104 Hondius, David 237 Herreros, Antonio Garcia de 100 Hong, Li 204 Herzog, Rebecca 186 Hong, Mun-Gwan 103, 119, 223
318 Hongxiu, Yu 135 Hunter, Christie 91, 156, 158, 217, 240, 247 Hong, Youn Hee 138 Hunt, Nicholas 241 Hoopmann, Michael 264 Hurbin, Amandine 106 Hoor, Klaske ten 100 Hürlimann, Mikko 173 Hoozemans, Jeroen 237 Hu, Tony 98 Horejs-Höck, Jutta 180 Hwang, Hui-Yun 196 Horlacher, Oliver 205, 262 Hwang, Jaesung 163 Hornburg, Daniel 229 Hye, Abdul 107, 159 Hornshaw, Martin 177 Hyett, Jon 270 Horvatovich, Peter 78 Hyman, Bradley T. 232 Hotzz, Eugenio 254 Hou, Guixue 117, 157, 246 Hou, Jing-Li 242 I Housley, Michael 192 Hovasse, Agnes 250 Iaconis, Daniela 258 Hovasse, Agnès 218, 249 Iavarone, F. 170 Hovemann, Bernhard 228 Iavarone, Federica 232 Hrabakova, Rita 194 Ibáñez, Borja 184 Hsu, Hong-Ming 149 Ibarrola, Nieves 217 Hsu, Pang-Hung 261 Ide, Jennifer L. 125 Huali, Shen 204 Iesmantavicius, Vytautas 31 Huang, Han-Wen 149 Ignjatovic, Vera 82 Huang, Honggang 45, 185 Igrejas, Gilberto 212, 263 Huang, Jiangming 203 Ihnatová, Ivana 118 Huang, Jincui 190, 261 Iida, Fumie 203 Huang, Jiqing 224 Ikeda, Yoshihiko 223 Huang, Kun 163 Ikehara, Yuzuru 206 Huang, Yu-Chen 248 Ilag, Leopold 196 Hubbard, Simon 215, 218 Ilgisonis, Ekaterina 260 Huber, Christian G. 109, 180 Ilhame, Turenhout 131 Huber, Wolfgang 196 Iliio, Carmine Di 164 Huelmos, Ana 221 Ilio, Carmine Di 211, 234 Huerga, Héctor 160 Iloro, Ibon 157, 239 Huerta-Ocampo, José A. 171 Imamura, Haruna 152 Huerta-Ocampo, José Ángel 146 Imanishi, Susumu 182 Hughes, Christopher 242 Imler, Jean-Luc 256 Huhmer, Andreas 187, 188, 217, 263 Iñarrairaegui, M. 131 Hühmer, Andreas 217 Indeykina, Maria 116 Hulstaert, Niels 124, 260, 265 Inekci, Dilek 166 Humblot, Patrice 176 Infusini, Giuseppe 100 Hummon, Amanda 21 Ingbar, David 169 Hung, Yu-Chiang 146 Inglese, Elvira 105 Hunt, Donald 16, 31 Ingvar, Christian 126
319 Inoue, Masaki 101 Jagtap, Pratik 169 Iommarini, Luisa 270 Jahangiri, Marjan 227 Ionov, Oleg 164 Jain, Antrix 119 Iovanna, Juan-Lucio 133 Jain, S.K. 102 Irimura, Tatsuro 206 Jakobsen, Lene 134 Isaac, Giorgis 156 Jakobsson, Joel 163 Ishibashi-Ueda, Hatsue 223, 225 Jakobsson, Per-Johan 202 Ishihama, Yasushi 151, 152, 251, 265 Jalali, Subhadra 169, 182 Ishihara, Makoto 54 James, P. 33 Ishikawa, Chihiro 239 James, Peter 7, 9, 13, 16, 43, 57, 75, Ishwarari, Sourav 228 116, 123, 168, 257 Islam, Md. Shariful 228 Jana, Vidic 106 Islam, Mohammad 260 Jang, Eunsun 164 Ismail, Mohd 246 Jang, Hye Ock 273 Isserlin, Ruth 152 Jang, Jin-Young 111 Itakura, Yoko 76, 206 Janssen, Jeroen JWM. 154 Ito, Haruka 191 Janz, Niklas 178 Itoh, Yoshito 145 Jaquinod, Michel 247, 249 Ito, Shinji 165 JA, Remond 131 Ivanisenko, Timofey 257 Jarkovska, Karla 228 Ivanisenko, Vladimir 257, 269 Jave-Suarez, Luis 102 Ivanov, Alexis 255 Jawa, Priyanka 172 Ivanova, Olga 131 J.Blanco, Francisco 199 Ivanov, Mark V. 101, 262 Jehmlich, Nico 211, 215 Ivanov, Nikolai 201 Jenkins, Rosalind 194, 242 Ivanov, Nikolai V. 195 Jensen, Karina Tveen 151, 185, 246 Ivanov, Vadim 131 Jensen, O. 31 Ivanov, V.T 197 Jensen, Ole 31, 129, 136, 190 Iwaki, Jun 76, 206 Jensen, Ole N. 250 Izadi, Sadegh 102, 229 Jensen, Pia S. 226 Izquierdo, Alicia 184 Jeong, Seul-Ki 268, 269 Izquierdo-Alvarez, Alicia 186 Jeong, Sung Hun 185 Izquierdo, Irene 182 Jeon, Seung-Woo 173 Jessulat, Matthew 257 Jian, Chi 245 Jiang, Junyi 245 J Jiang, Xiaoyue 217 Jiang, Ying 181, 245 jaberi, Abbas rahimi 230 Jiang, Zheng 248, 251 Jacobsen, Susanne 166, 167 Jiao, Jing 76, 203, 242 Jacobs, Ryan 126, 187 Jia, Xiaoying 130 Jacobsson, Bo 166 Jiménez, C. 43 Jacoby, Edgar 260 Jimenez, Connie 75, 129 Jágr, Michal 191
320 Jimenez, Connie R 131, 153, 266 Junqueira, Magno 135 Jimenez, Connie R. 154 Jiménez, Connie R. 153 Jimenez, Conny 43 K Jiménez, Cr 141 Jin, Hong 133 Kaboord, Barb 129 Jin, Jonghwa 162, 164 Kacerovsky, Marian 166, 167 Jin, Ke 257 Kadek, Alan 124 Ji, Weihua 247 Kadie, Carl 210 Joenväärä, Sakari 259 Kagan, Jacob 75, 125 Joergensen, Malene 140 Kahng, Hyung-Yeel 173 Johansson, Anna 269 Kahraman, Abdullah 244 Johansson, Henrik 248 Kainov, Denis 182 Johnson, Christine 213 Kaji, Hiroyuki 76, 206 Johnson, Matt 169 Kakimoto, Yu 165 Jones, Alan 222 Kalamkarov, Grigori 216 Jones, Andrew 215, 218 Käll, Lukas 108 Jones, Andy 217, 262 Kallo, Gergo 160 Jones, Mavis 271 Kalume, Dario 129 Jönsson, Göran 126 Kamada, Haruhiko 101, 220, 235 Jooa, Thomas O. 164 Kamal, Abu Hena Mostafa 144 Joos, Thomas O 107, 161, 243 Kamali-Sarvestani, Eskandar 267 Joos, Thomas O. 107, 122, 129, 262 Kamieniczna, Marzena 181 Jorge, Inmaculada 191, 220 Kampf, Caroline 74, 191 Jørgensen, Malene 33 Kan, Alison 98 Jorrín, Jesús 7, 10 Kang, In-Cheol 234 Jorrín-Novo, Jesús 174 Kang, Mee Joo 111 Jorrín-Novo, Jesús V. 177 Kang, Sung Gyun 177 Joshi, Hiren 263 Kang, Taewook 165 Joshua, Vijay 202 Kapandji, Natacha 157 Jozefowicz, Anna Maria 172 Kaplan, Desmond 243 Jr., Stanley M. Stevens 184 Kaplon, Joanna 197 J.Simpson, Richard 32 Karkampounas, Spiros 173 Juarez-Belaunde, Alan 231 Karlsson, Niclas G. 203, 205 Jufri, Nurul Farhana 133 Karmazín, Karel 196 Juncker, David 216 Karpov, Dmitry A. 101 Jung, Eun Joo 111, 126 Karsdal, Morten 167 Jung, Kwang Hwan 178 Kashtanova, Elena 220 Jung, Stephan 149, 158 Kaspar, Dr. Stephanie 87 Jung, Sung 119 Kaspar, Stephanie 128, 172, 246, 249, 251 Jung, Sung Yun 117, 146 Kassem, Moustapha 134 Jung, U-Suk 173 Kast, Juergen 224 Junot, Christophe 237 Katada, Kazuhiro 145
321 Katare, Deepshikha Pande 102 Kim, Hyesoo 244 Katsafadou, Aggeliki 173 Kim, Hyoung Kyu 185, 223 Kaufman, Kimberley 104 Kim, Hyunsoo 164 Kaufman, Kimberley L. 100, 104, 123 Kim, Hyunwoo 142 Kaur, Inderjeet 169, 182 Kim, Inhae 195 Kaur, Kiranjot 216 Kim, Jae Ho 165 Kaushal, Sunjay 224 Kim, Jang Seong 144 Kawai, Akira 100 Kim, Jeong Hoon 240 Kawano, Shin 265 Kim, Jin-Ock 143 Kawshima, Yusuke 203 Kim, Jin Young 102, 171, 196 Kazakova, Irina 216 Kim, Jonghyun 173 Kearney, Paul 18, 20 Kim, Kyunggon 162, 164 Kearsley, John 99, 112 Kim, Min-Jeong 173 Keijzer, Jeroen de 212 Kim, Min-Ji 230 Keilhauer, Eva C. 59 Kim, Nari 185, 223 Kekunaya, Ramesh 169, 182 Kim, Sang-Hyun 116 Kelleher, Neil L. 61 Kim, Sang Jin 162 Keller, Gordon 226 Kim, Sanguk 195 Kelm, Jens 146 Kim, Seonwoo 230 Kempf, Stefan J. 231 Kim, Seung Il 138, 173, 177 Kentsis, Alex 271 Kim, Soo Jung 173, 178 Keppler, Bernhard 109 Kim, Soo Young 236 Kerjaschki, Dontscho 128 Kim, Sun Tae 171 Kerr, Candace L 244 Kim, Sun Woong 143 Kesavadev, Jothydev 225 Kim, Susan 271 Kessel, Kim E.M. van 158 Kim, Yeoun-Jin 115, 162 Khan, Alamgir 105 Kim, Yong Chul 171 Khan, Ayesha 233 Kim, Yongdai 163 Khan, Javed 260 Kim, Yong-In 163 Kholy, Leila El 247 Kim, Young Hwan 178 Khoo, Kay-Hooi 149 Kim, Young Hye 102 Khorana, Amrat 181 Kim, Youngsoo 111, 162, 164 Khristenko, Nina 68 Kim, Yu Ji 171 Kiehne, Andrea 205, 249 Kinoshita, Naohiko 74 Kim2, Doh Kwan 230 Kinosita, Naohiko 270 Kim4, Min-Ji 230 Kinsinger, Christopher 43, 66, 75 Kim4, Seonwoo 230 Kinsner-Ovaskainen, Agnieszka 218 Kim, A-Young 236 Kiprijanovska, Sanja 114, 163 Kim, Chan-Wha 228 Kireev, Kirill 269, 270 Kim, Choong Won 111, 126 Kirik, Ufuk 257 Kim, Doh Kwan 230 Kislinger, Thomas 226 Kim, Gun-Hwa 138 Kita, Takeshi 71 Kim, Hokeun 192 Kitazume, Shinobu 204
322 Kito, Keiji 191 Koncarevic, Saša 158 Kitteringham, Neil 194, 242 Kondo, Tadashi 100, 265 Kiyonami, Reiko 248 König, Simone 50, 240 Kizhakkedathu, Jayachandran N. 130 Kononihin, Aleksey 269 Klafki, Hans-Wolfgang 147 Kononikhin, Aleksey 269, 270 Klammer, Martin 130 Kononikhin, Alexey 68, 82, 116, 164 Klareskog, Lars 202 Kononokhin, Alexey 216 Klein, Jon 268 Kontostathi, Georgia 107 Klein, Sebastian 192 Kontro, Hilkka 259 Klein, Theo 263 Konvalinka, Ana 246 Klimmeck, Daniel 196 Konzer, Anne 192 Klingel, Karin 225 Koppensteiner, Herwig 183 Klingenspor, Martin 147 Kopylov, Arthur 241 Klingler-Hoffmann, Manuela 241 Korbut, Ryszard 235 Klinguer-Amour, Christine 249 Korth, Carsten 233 Klip, Harry 100 Kostrukova, E.S 197 Klumpp, Klaus 255 Ko, Tae Hee 185 Knapman, Thomas 77, 109, 242 Ko, Tae- Hee 223 Knappe, Daniel 210 Kotrcova, Eva 228 Knol, Jaco C. 153, 154 Koudelka, Tomas 135, 136 Knüchel, Ruth 119 Kourjian, Georgio 210 Koabayashi, Daiki 129 Kouvonen, Petri 47, 250 Kobarg, Jan Hendrik 261 Kovalchuk, Sergey 131 Kobayashi, Daiki 126 Kovalchuk, S.I 197 Kobayashi, Satoshi 204 Kovarova, Hana 228 Kocher, Thomas 161 Kowalski, Michael 217, 247 Koch, Heiner 103 Kozicki, Antje 249 Koch, Marianne 113 Kozin, Sergey 116 Koch-Nolte, Friedrich 135 Krãger, Marcus 228 Koczorowska, Maria Magdalena 33 Kramer, Karl 103 Kodera, Yoshio 216 Krastins, Bryan 75, 194, 224 Kogel, Ulrike 195 Kratchmarova, Irina 181 Koh, Ching Chiek 167, 250 Kratochwill, Klaus 44, 186 Kohlbacher, Oliver 80 Kraus, Hans-Joachim 54 Kohli, Ajay 196 Krauter, Jürgen 130 Kohn, Jonathan 181, 216, 258, 270 Kremser, Leopold 173 Koh, Young Ho 236 Kreutz, Dominique 109, 199, 243 Ko, Kyung Soo 185, 223 Krieger, José Eduardo 224 Kölbl, Heinz 113 Kriegsmann, Jörg 124 Kolchanov, Nikolay 257 Kriegsmann, Mark 124 Kollipara, Laxmikanth 235 Krijgsveld, Jeroen 77, 196, 242 Komatsu, Setsuko 37 Krishnan, Lissy 225 Komor, M.A. 131 Krishnan, Shibu 159
323 Krisp, Christoph 162 Kwon, Ho Jeong 196 Kristensen, Jacob Hull 167 Kwon, Joseph 177, 178 Kristensen, Lars P. 226 Kwon, Soon Jae 171 Kristensson, Krister 253 Kwun, Sun Young 114 Kriz, Jasna 233 Krizsan, Andor 210 Kroes, Roger A. 272 L Krohina, Kseniya 164 Krovidi, Ravi K 148 Labaer, J. 42 Krüger, Marcus 146, 192 LaBaer, Joshua 69, 75 Krug, Karsten 273 Labas, Valérie 176 Kruszewski, Marcin 166 Labiscsak, Peter 110 Kubelka-Sabit, Katerina 114, 163 Labots, Mariette 153 Kubota, Daisuke 100 Labra-Barrios, María L. 120 Kuharev, Joerg 127, 263, 264 Ladouce, Romain 123 Kuhn, Karsten 149, 158 Lafitte, Daniel 184 Kuklenyik, Susan 222 Laforte, Veronique 216 Kukurba, Kimberly 195 Lagerstedt, Linnea 34 Kumar, Rekha 193 Lahtinen, Heini 171 Kumar, Rekha Vijay 121 Laires, Rita 178 Kumar, Sachendra 151, 233 Lai, Wu-Wei 116 Kumar, Sanjeev 162 Lai, Xianyin 99, 138 Kumar, Sharad 133 Lai, Zon W. 130 Kumar, Vipin 211 Lamberti, Cristina 175 Kume, Hideaki 115, 138 Lambour, Thomas 255 Kuno, Atsushi 76, 206 Lam, Carly S. 270 Kunwar, Pooja 267 Lam, Chuen 150 Kuo, Chu-Wei 149 Lamerz, Jens 255 Kupèík, Rudolf 152 Lam, Henry 264 Kuratsu, Junichi 129 Lam, Maggie 79 Kurbasic, Emila 116 Lam, Melody Man Ting 127 Kurosky, Alexander 47 Lam, Thomas Chuen 270 Kurpisz, Maciej 181 Lanau, Lucia 128 Kuruc, Matthew 134 Landegren, Ulf 248 Kusebauch, Ulrike 12 Landén, Mikael 163 Kushal, Sunjay 82 Landgraf, Rainer 156 Kussman, Martin 65 Landi, Claudia 175, 233 Kussmann, Martin 36, 72, 82, 138, Lane, Catherine S. 203 144, 177, 268 Lang, Benedikt 164, 215, 244 Kuster, Bernhard 57, 103, 157, 267 Langen, Hanno 255 Ku, Wei-Chi 151 Lang, Frederick F. 272 Kwak, Yeon Ju 273 Langley, Sarah R. 168, 227 Kwok, Tony 169 Langridge, James 156, 240, 259
324 Lankoff, Anna 166 Lee, Heekyoung 147 Lanni, Stella 232 Lee, Hee-tak 195 Lanouette, Sylvain 136 Lee, Hong-Gu 173 Lantican, Nacita 196 Lee, Jae-Sung 173 Lapierre, Vanessa 253 Lee, Jeong-Eun 116 Larbi, Ben 131 Lee, J Eugene 67 Larina, Irina 68, 269, 270 Lee, Jonghoon 143 Larkin, Selena 19, 56 Lee, Jong Kyun 100 Larrasa, José 213 Lee, Jung-Hyun 177 Larriba, María Jesús 104 Lee, Ju Yeon 102 Larrosa, María 145 Lee, Kimberly 130 Larsbrink, Johan 172 Lee, Kwang Hyuck 100 Larsen, Martin 16, 35 Lee, Kyu TaeK 100 Larsen, Martin R 244 Lee, Ling 47 Larsen, Martin R. 134, 226 Leeming, Diana 167 Larsen, Martin Rossel 185 Lee, Minhyung 201 Larson, Goran 76 Lee, Min-Jung 268, 269 Larson, Göran 203, 206 Lee, Sandy 101 Larsson, Jessica Holmén 163 Lee, Sang-Bum 173 Lateef, Syed Salman 148 Lee, Sang Chul 144 Laterza, Rosa 113 Lee, Sang-Won 192, 243 Latosinska, Agnieszka 118 Lee, Sang-Yeop 138 Lau, Ling San 111 Lee, Soo Youn 100 Laumen, Helmut 147 Lee, Soo-Youn 230 Laurell, Thomas 237 Lee, Sora 185, 223 Laureto, Patrizia Polverino De 244 Lee, Sung Ryul 185 Lau, Wai Hung 127 Lee, Sung-Ryul 223 Lavarello, Chiara 105 Lee, Yeol Gyun 138 Lawless, Craig 229, 238 Lefebvre, Christophe 228 Lazarev, Vassily N. 101 LeGall, Sylvie 210 Lazic, Savo 226 Legent, G. 202 Lebert, Dorothée 249 Léger, Thibaut 194, 248 Leber, Yvonne 135 Legrain, P. 38, 62 Leblanc, Eric 122 Legrain, Pierre 8 Lebrilla, Carlito 190, 261 Legram, Pierre 58 Lecchi, Cristina 187 Lehmann, Kåre 117 Leclercq, Celine 166 Lehmann, Robert 113 Lee, Boram 143 Lehmann, Sylvain 237 Lee, Byoung-Doo 223 Lehmann, Sylvia 106 Lee, Chaeeun 111 Lehmann, Sylvia G 160 Lee, Fu-An 149 Lehmann, Sylvia G. 112, 113 Lee, Hangyeore 243 Lehm, Manuel 256 Lee, Han-Na 228 Lehtiö, Janne 159, 248
325 Leikin, Sergey 175 Lilley, Kathryn 139, 150, 259 Leilei, Xu 135 Lilley, Kathryn S 32 Leite, Renata E. 236 Lim4, Shinn-Won 230 Lejon, Veerle 253 Lima-Landman, Maria Teresa 205 Lemeer, Simone 103 Li, Maoyu 150 Lenco, Juraj 166, 167 Lim, Chwee Teck 101 Lendal, Sara E. 134 Li, Menglin 165 Leng, Mei 119 Lim, Hye Li 177 Leng, Wenchuan 117 Liming, Wei 204 Lenz, Christof 37 Lim, Jong-Sun 268, 269 León-Ávila, Gloria 120 Lim, Key-Hwan 135 Lequerre, T. 202 Limonier, Franck T.M 219 Lerma-García, María Jesús 179 Lim, Shinn-Won 230 Lescuyer, Pierre 241 Lim, Yoon Pin 101 Lesur, Antoine 128, 162 Lin, Chai-Ching 175 Leu, Yann-Lii 184 Lincoln, Lynette 148 Levander, Fredrik 266 Linderbäck, Klas 269 Levis, Mark 130 Lind, Sara Bergström 35 Levitsky, Lev I. 262 Lindsey, Merry 222 Lewis, Steven 262 Lindsey, Merry L. 120 Liang, Hui-Chung 159 Liñeiro, Eva 174 Liao 70 Lingner, Joachim 121 Liao, Hanqing 262 Li, Ning 151 Liao, Lujian 235 Linke, Dennis 136 Liao, Pao-Chi 116, 212 Link, Marek 167 Liberto, Maria Carla 210 Lin, Kuo-I 149 Lichtenauer, Anton 186 Lin, Liang 157, 245, 246 Lichter, Justin 225 Lin, Ling 118 Lichti, Cheryl F. 272 Lin, Pei-Yi 151 Licker, Virginie 160 Lin, Wanchang 156 Li, Dong 142 Lin, Yun-Lian 237 Lieberenz, Marcus 267 Li, Peng 126 Liebler, Daniel C. 163 Lipka, Daniel B. 196 Li, Guo-Qing 242 Li-Pook-Than, Jennifer 195 Li, Hong 114 Lippolis, Rosa 232 Li, Hongdong 142 Lira, Alfonso 111 Li, Hui 225 Li, Rachel H 195 Li, Jing 251 Lira, Rodolfo Ayala 211 Li, Jun 130 Li, Ru 224 Li, Ka Wan 237 Lisacek, Frederique 205, 262 Li, King Kit 150, 270 Li, Si 242 Li, Lan 143 Lisitsa, Andrey 67, 260 Li, Lei 181 Liu, Cuihua 136
326 Liu, Mingwei 146 Longo, Valter 105 Liu, Ning 181, 270 Longuespée, Rémi 159 Liu, Peter 226 Lopes, Carlos 168 Liu, Rong-Zhong 242 Lopez-Almodovar, Luis F. 221 Liu, Shilian 235 López-Fernández, Carlos 200 Liu, Siqi 117, 157, 245, 246 Lopez-Ferrer, Daniel 49, 188 Liu, Tao 125 López-García, Maria Teresa 190 Liuu, Sophie 247 López, Javier 198 Liu, Wanlin 146 Lopez, Juan A. 139, 221 Liu, Xia 133 López, Juan A . 147 Liu, Xiaodong 204 López, Juan A. 185 Liu, Xiaohui 111, 142, 216 Lopez, Juan Antonio 191, 221, 222 Liu, XiaoHui 242 López, Juan Antonio 184, 231 Liu, Xiaoqian 247 Lopez-Lucendo, Maria 100, 101 Liu, Xiaoquan 217 Lopez-Lucendo, María 104 Liu, Yansheng 136 López-Lucendo, María 272 Liu, Ying 117 López, Marcos Caballero 172 Liu, Yinkun 107 Lopez, Mary 194 Liu, Zan 112 Lopez, Mary F 224 Li, Xinping 217 López-Millán, Ana Flor 176 Li, Xuejun 112 Lopez, Sheila 114 Li, Yanchang 117 Lopiano, Leonardo 229, 238 Li, Yanyan 181 Lorenzo, Seila 108 Li, Yong 99, 112 Lorkova, Lucie 124 Li, Zhen 195 Loroch, Stefan 35 Li, Zheng 204 Lo, Samuel Chun-lap 127 Llansola, Marta 158 Lößner, Christopher 55, 158 Llombart, Victor 160 Lottspeich, Friederich 56 Llombart, Víctor 160 Louette, Joel 248 Lobas, Anna 158 Louis, Edouard 106, 159, 198 Lobas, Anna A. 101, 262 Loureiro, Liliana 164 Lobinski, Ryszard 174 Lourenço, Ana S. 186 Lobo, Alan 201 Lourido, Lucia 199, 268 Lochmüller, Hanns 258 Lourido, Lucía 199, 200 Lock, Stephen 161, 243 Louwagie, Mathilde 247 Loco, Joris Van 240 Lou, Xiaomin 117, 157 Loesssner, Daniela 130 Lovestone, Simon 159 Løfgren, Bo 148 Lowe, Christopher R. 151 Loge, Eike 161 Low, Teck 142 Loipetzberger, Andrea 109 Low, Teck Yew 256 Lokhov, Petr 145 Lubeck, Markus 246, 249 Lo, Kwok Wai 127 Lubzens, Esther 177 Longone, Patrizia 187 Lucacchini, Antonio 111, 232
327 Lucia, Monteoliva 214 Maffioli, Elisa 198 Lucio, Victor Manuel Bautista De 211 Magalhães, Ilídio 214 Luddi, Alice 233 Magdeldin, Sameh 136, 150, 208, 215 Ludolph, Albert 140 Magdolen, Viktor 130 Lugowski, Andrew 152 Magee, Kieran 222 Lu, Haojie 76, 203, 216, 242 Maggie 79 Luider, Theo 100, 220, 237 Maggiolini, Marcello 115 Luís, Inês M. 152 Magliozzi, Roberto 256 Lukasheva, Elena 178 Magnan, Antoine 160, 191 Luna-Arias, Juan P. 120 Magraoui, Fouzi El 76, 236 Lundberg, Emma 74, 81, 141 Mahajan, Vinit 167 Lund-Johansen, Fridtjof 108 Mahajan, Vinit B. 71 Lunn, Ruth 169 Mahboob, Sadia 65, 105 Lunyak, Victoria V 224 Mahdessian, Diana 141 Luo, Yue 119, 120 Maier, Andrea 155 Lu, Ssu Yi 101 Maier, Sandra 215 Lüthje, Sabine 176 Ma, Jie 151 Lu, Wenyuan 260 Majumdar, Debabrata 201 Lu, Xiaoning 99, 188 Majzoub, Karim 256 Lu, Yali 245 Makaju, Aman 225 Lygirou, Vasiliki 107, 158 Makridakis, Manousos 118 Ly, Linda 104 Malaise, Michel 198 Lyssiotis, Costas 257 Malchow, Sebastian 225 Malek-Hosseini, Ali 180 Malekzadeh, A 141 M Malhotra, Atul 168 Malhotra, Darpan 162 Maass, Peter 166 Malik, Shabnam 102 Macák, Jan 152 Mallawaaratchy, Duthika 104 Maccarrone, Giuseppina 218 Mallawaaratchy, Duthika M. 100, 104 MacCoss, Dr. Michael 89 Malm, Erik 141 MacCoss, M. 59 Malmierca, Mónica G 193 MacCoss, Mike 14, 15, 16 Malmström, Vivianne 202 Macedo, Jessica Kele A Mamede-Branca, Rui 248 Macek, Boris 273 Manadas, Bruno 164, 257 Machaalani, Rita 241 Mancano, Giorgia 232 Mack, David 201 Mancuso, Francesco 190 Mactier, Swetlana 104 Mancuso, Francesco M. 145 Maddalo, Gianluca 197 Mandal, Amit 232 Maddelein, Davy 124, 260 Mangas, Alipio 227 Madero, Luis 132 Mangiapane, Erika 174 Madrid, Vicente 120 Mani, Jan 185 Maeda, Makiko 220 Manissorn, Juthatip 200
328 Mann, Graham 123 Marsal, Carlos 231 Mann, Greg 263 Marshall, Melanie 168 Mannix, Rebekah 271 Marshall, Peter 260 Mann, Mathias 42, 57, 134, 139 Martella, Roberto 105 Mann, Matthias 149, 153, 229, 246, 256 Martens, L. 57 Man, Petr 124 Martens, Lennart 60, 124, 224, 260 Manrique, Marina 253 Martina, Byron 209 Manteca, Angel 190 Martín-Bernabé, Alfonso 112, 113 Mantua, Valentina 232 Martinez, A. 44 Manunta, Paolo 220 Martinez-Aguilar, Juan 114 Manzano-Román, Raúl 254 Martínez-Bartolomé, Salvador 60 Marana, Riccardo 156 Martinez, Elena 128 Marçal, Nelson 168 Martínez, Elena 128 Marcellin, Marlène 168, 181, 218 Martínez, Enrique Santamaría 76 Marchetti-Deschmann, Martina 128 Martínez, Fernando Vivanco 22 Marchionni, Mark A. 125 Martínez-Gomariz, Montserrat 213 Marchi, Umberto De 138, 177 Martínez, Gonzalo 183 Marcilla, Antonio 139 Martínez, Jose Luis 213 Marcilla, Miguel 272 Martínez-Maza, Rodrigo 231 Marcondes, Fernanda 174 Martinez-Pinna, Roxana 163 Marcus, K. 47 Martínez-Ruiz, Antonio 184, 186 Marcus, Katrin 19, 76 Martin, Fernando Ariel 123 Mareque, Maria Jesus Iglesias 223 Martin, Florian 195, 201 Margutti, Paola 139 Martin, Jesus 145 Mariconti, Mara 253 Martín, Juan F 192 Mariethoz, Julien 262 Martin, Laurent 266 Marimpietri, Danilo 105 Martin-Lorenzo, Marta 140, 223, 246 Marina, Anabel 186, 200, 272 Martín, Luna 128 Marina, M.L 178 Martin, Maria 264 Marin, Elvira 214 Martin-Rojas, Tatiana 221 Marinho, Catarina 263 Martin-Rufian, Mercedes 112 Marinis, Laura De 156 Martins, Joana 177, 214 Marino, Fabio 242, 243 Martins, Jorge 174 Marin-Vicente, Consuelo 116 Martins, Luisa Louro 178 Marko-varga, G 62 Martín, Verónica Díaz 254 Marko-Varga, Gyorgy 9, 34, 73, 78 Marton, Ildiko 110 Marko-Varga, György 126, 131, 226, Martorana, Alessandra 176 237, 252, 272 Maruyama, Katsuya 203 Markowski, Todd 215 Marx, Kristina 205, 249 Marogna, Gavino 139 Marzano, Valeria 232 Maroto, Aroa S. 140, 223 Marzoq, Aseel 108 Marquez, Javier 112 Masala, Giovanna 253 Marrec-Croq, Françoise Le 228 Masood, Afshan 144
329 Mastalski, Thomas 236 Mazzucchelli, Gabriel 106, 159, 198, Mastro, Lucia Del 160 244 Matafora, Vittoria 220 McCormick, Susan P 193 Mateos-Hernández, Lourdes 253 McDonald, Cassandra 123 Mateos, Jesus 108, 268 McDonald, Fiona 271 Mateos, Jesús 190, 199, 200 McDonald, Kerrie 104 Mates, Jose M. 112 McDonald, Kerrie L. 100 Mathavan, Sinnakaruppan 195 McDonnell, L. 45 Mathew, Boby 232 McDonnell, Liam 246 Mathieson, Toby 241 McKay, Matthew 104, 162 Mathieu, Chantal 183 McLaughlin, Tracey 195 Ma, Tianran 204 McMahon, Kelly 229, 238 Matic, Ivan 123 McMaster, Robert 34, 60 Matikainen, Sampsa 182 M, Cortes Jesus 193 Mato, J.M 34 McQuade, Leon 98 Mato, José M. 7 Mctier, Swetlana 104, 123 Mato, Jose María 36 McWilliams, Lisa 222 Matovu, Enock 253 Mebarki, Mouniya 123 Matros, Andrea 172 Mechref, Yehia 120 Matsuda, Atsushi 76, 206 Mechtler, Karl 108, 129, 251, 263, 265 Matsumoto, Masaki 265 Medard, Guillaume 103 Matsushita, Kazuyuki 216 Medina, Alberto 271 Mattheij, Nadine J.A 224 Medina-Aunon, J. Alberto 272 Matthew 77 Medina, Isabel 184 Matthiesen, Rune 168 Mehriar, Peiman 208 Mauch, Cornelia 170 Mehta, Neel 234 Maurer, M. 110 Meier, Scott 129 Mauri, Pierluigi 176 Meijer, A 131 Maxwell, Robert 243 Meijer, Gerrit A. 153 Mayan, Maria D. 108 Meijer, Marieke 158 May, Caroline 47, 76 Meilhac, Olivier 220 Mayer, Gerhard 74 Meissner, Felix 44, 229 Mayer, Ramona 118 Meistermann, Hélène 255 Mayer, Rupert 109, 199, 243 Meitei, Ningombam Sanjib 205 Mayne, Janice 136, 226 Melamed, Dganit 151 Mayr, M. 54 Melchert, Stephanie 255 Mayr, Manuel 54, 79, 168, 227 Melida, Hugo 141 May, Robert 106 Mellby, Linda Dexlin 201 Mayr, Ursula 168 Melnik, Andre 244 May, Stephanie 229 Melo, Ivan Sanchez-De 205 Maza, Rodrigo M 173 Melo, Matilde 164 MAza, Rodrigo Martinez 172 Menden, Michael 167 Mazzucato, Roberta 236 Mendes, Marta 100
330 Mendes, Vera M 257 Miladinovic, Saša 161 Mendes, Vera M. 164 Milani, Emanuela 59 Méndez, Jose Antonio 213 Milardi, Domenico 156 Méndez, Lucía 184 Milkowski, Carsten 178 Mendez, Magali 268 Miller, Mickey 225 Mendoza, Guillermo 120 Miloš, Barut 106 Mendoza, Luis 12, 264 Milsom, Michael D. 196 Menetrey, Jean-Philippe 266 Milz, Fabian 50 Menon, Rajasree 142, 143 Minamino, Naoto 223, 225 Menschaert, Gerben 32 Minatoya, Kenji 225 Menzel, Stephan 135 Ming, Ngai Sai 148 Mera, Isabel G. Fernández de 253 Minucci, Saverio 105 Merchant, Michael 268 Miranda, Maria 234 Mercuri, Nicola B. 187 Mirzaei, Mehdi 137 Merida, Isabel 183 Misato, Kazuki 235 Merkel, Dietrich 106 Misek, David E. 204 Merlini, Giampaolo 81 Mishra, Rachana 224 Meroni, Valeria 253 Misra, Sanjay 227 Mesa, Raquel 220 Mitall, Parul 241 Messana, I. 170 Mitra, Vikram 149 Messana, Irene 156 Mitsa, Dimitra 194 Metzger, Fabian 140, 233 Mittasch, Juliane 178 Meuwis, Marie Alice 159 Mitulovic, Goran 113, 144, 158, Meuwis, Marie-Alice 106, 159, 198 161, 248, 262 Meyer, H. 55 Mizuguchi, Souhei 129 Meyer, Helmut 55 Mizushima, Katsura 145 Meyer, Helmut E. 76, 119, 147, 169, 236 M., Jeffrey 71 Meyer, Markus 205 Mkrtchyan, G. 196 M.Gstaiger 59 Möbius, Thomas W.D. 225 Mias, George 195 Mochizuki, Hideki 235 Miccolo, Claudia 105 Mock, Hans-Peter 172 Michalik, Stephan 211 Moein, Mohammad Reza 208 Michalski, Annette 246, 249 Moertl, Simone 231 Michel, Jaquinod 147 Mohamed, Ahmed A 125 Michelland, Sylvie 150 Mohamedali, Abidali 98, 260 Michel, Malaise 106 mohammadi, Abbas 102 Midorikawa, Uichi 129 Mohammadi, abbas 230 Mihailovic, Marjia 190 Mohammadi, Abbas 102, 180, 200, Mijn, Johannes C. Van Der 153 209, 229, 230 Mijn, Koen Van Der 153 Mohammadi, Somayeh 200 Mikesh, Leann 170 Mohammed, Shabaz 77, 110, 142, Mikšík, Ivan 191, 198 242, 243 Mikus, Maria 36 Mohanty, Bimal 155
331 Mohanty, Pradeep 228 MorenP-Luna, Rafael 139 Mohanty, Sasmita 155 Moreu, Jose 221 Mohsenchian, Atefeh 269 Morisaki, Takayuki 225 Moise, Adrian 189 Morita, Mayuko 145 Moiyadi, Aliasgar 115, 233 Moritz, Rob 54 Molero, Gloria 141, 214 Moritz, Robert 66, 75, 211 Molitoris, Bruce 138 Moritz, Robert L 213 Mollah, Sahana 56 Moritz, Robert L. 264 Möllecken, Christian 169 Morris, Jeffrey 262 Møller, Ian Max 250 Morrissey, Brian 113 Molloy, Mark 104, 114, 162 Moruz, Luminita 108 Molloy, Mark P 240 Moshkovskii, Sergei A. 101 Mombrun, Adrien 251 Moskal, Joseph R. 272 Monge, Marta 125, 128 Moskulak, Christopher 170 Mongera, Sandra 131 Mostertz, Jörg 183 Moniatte, Marc 121 Mostovenko, Ekaterina 272 Mon, Naing Naing 101 Motta, Sara 176 Monsarrat, Bernard 163, 181, 255, 264 Moura, Arlindo 174 Montalban, Xavier 231 Mourato, Miguel P. 178 Montaner, Joan 160 Mourino-Alvarez, Laura 221, 231, 239 Montaner, Sergio 139 Mouton-Barbosa, Emmanuelle 163 Montecillo, Andrew 196 Mouz, Nicolas 249 Monte, Enrique 193 Mueller, A.C 110 Monteiro, Filipa 177 Mueller, Margareta M. 129 Monteiro-Moreira, Ana Cristina 174 Mukai, Yohei 101, 220, 235 Monteoliva, L. 48 Mukhopadhyay, Debashis 228 Monteoliva, Lucia 141, 213 Mukhopadhyay, Kiran 228 Monteoliva, Lucía 7, 10 Mulder, Chris JJ 131 Montes, Melania 103 Mullen, William 118 Monti, Maria 258 Muller, Markus 205, 262 Moon, Jeong-Hee 240 Müller, Markus 241 Moon, Myeong Hee 102 Müller, Martin 173 Moon, Pyong-Gon 116 Müller, Sebastian 268 Moon, Yoon-Jung 177 Müller, Stefan 103 Morada, Anthony 152 Mundodi, Suparna 216 Moradi, Mona 269 Mun, Dong-Gi 192 Moral-Dardé, Verónica 231 Muñoz, Alberto 104 Morales-Cid, Gabriel 203 Muñoz, Amalia 215 Mora, M.I 131 Muñoz-Bernal, Eugenia 174 Moreira, Renato 174 Muñoz-Galdeano, Teresa 173, 231 Moreno, Armando 187 Muñoz, J. 30 Moreno, Frederico 174 Munoz, Javier 128 Moreno-Luna, Rafael 221, 222, 231 Muñoz, Javier 77, 271, 272
332 Muñoz-Rodriguez, Jose Ramon 145 Narvaez, Karla 234 Muntoni, Francesco 258 Na, Sang-Su 163 Muqaku, Besnik 199, 243 Naskou, Johanna 256 Muraoka, Satoshi 138 Nasso, Sara 264 Murata, Syota 209 Navajas, Rosana 183 Murphy, E. 44 Navarro, Andres Guerrero 190 Murphy, Elizabeth 44 Navarro, Pedro 127, 263, 264 Murphy, Mike 156 Navarro-Ruiz, Rosa 173 Murphy, Robert F. 123 Navarro-Ruíz, Rosa 231 Murr, Annette 161, 215 Ndung’u, Joseph Mathu 253 Murugesan, Nivetha 71 Ndung’u, Jospeh Mathu 253 Musacchio, Andrea 134 Negri, Armando 198 Mushtaq, Shamim 188 Neiman, Maja 159 Musicco, Clara 270 Neirynck, Nathalie 240 Muto, Sayaka 223, 225 Nenutil, Rudolf 118 Myers, Jenny E 156 Neri, Giovanni 232 Nesvizhskii, Alexey 71 Nesvizhskii, Alexey I. 151 N Neubauer, Hans 256 Neves-ferreira, Ana Gisele 128 Nagano, Kazuya 101, 220, 235 Neves-Ferreira, Ana Gisele 188, 254 Nagaraj, Nagarjuna 149 Neves, Sofia 168 Nagayama, Megumi 126 Neves, Vander 174 Nagyova, Miriam 228 Newbold, Jane 189 Nagy, Zoltan 161 Nezari, Hossein 139 Nagy, Zoltán 161 Ng, Eddy Wing Yin 127 Nahnsen, Sven 266 Ngoyi, Dieudonnée Mumba 253 Naik, Armaghan 123 Ngoyi, Dieudonné Mumba 253 Naito, Yuji 145 Nguyen, Tien Dung 153 Nakagami, Hirofumi 265 Nguyen, Uyen 216 Nakagawa, Tetsuya 239 Nicastri, Annalisa 122, 159 Nakagawa, Tomomi 206 Nice, Ed 74, 105 Nakano, Miyako 204 Nice, Edouard 66, 75, 98, 114 Nakatani, Takeshi 223 Nicklin, Matthew 77, 109 Na, Keun 172, 268, 269 Nicod, Laurent 160, 191 Nambu, Akiko 129 Nicolardi, Simone 247 Nam, Eunhye 152 Nicolle, Sarah 189 Nanjappa, Vishalakshi 121 Niemeyer, Dagmar 166 Nanni, Paolo 146 Nierop, Pim van 237 Naour, François Le 152 Nieto-Diaz, Manuel 173 Napli, Anna 115 Nieto-Díaz, Manuel 231 Narimatsu, Hisashi 46, 75, 76, 206 Nieto, Wendy 108 Narula, Kanika 149, 172 Ni, Jie 99
333 Nikeghbalian, Saman 180 Nowicka-Bauer, Karolina 181 Nikitina, Irina 164 Nunes, Fábio 122 Nikitin, Frederic 205, 262 Nunes-Miranda, Júlio 212 Nikolaev, Eugene 68, 116, 164, 269 Nussbaumer, Markus 156 Nikolaev, Eugeny 216 Nussupbekova, Aliya 224 Nikolaev, Evgeny 68 Nyman, Tuula 70, 182 Nikolic, Andrej 133 Nyul, Dávid 161 Nikseresht, Alireza 102, 209, 229, 230 Nilsson, Anna 242 Nilsson, Carol 43 O Nilsson, Carol L. 272 Nilsson, Jonas 203, 206 Obermayr, Philipp 248 Nilsson, Peter 69, 74, 103, 119, 159, Obraztsova, Olga 269 210, 223, 234 Obriot, Helene 238 Nilsson, T. 36 Obry, A. 202 Nilsson, Tommy 36, 67 Ocaranza-Sánchez, Raymundo 140 Nimeus-Malmström, Emma 116 Ochoa, Francisco 205 Nimsky, Christopher 130 Öckl, Patrick 233 Ning, Leung Chung 148 Odeberg, Jacob 191, 223 Ning, Zhibin 136, 226, 234 Odena, Antonia 165 Nishigori, Hiromitsu 225 Odriozola, Letizia 272 Nishigori, Mitsuhiro 223 Oeckl, Patrick 140 Nishimura, Motoi 209, 216 Oehler, Martin K. 241 Niyompanich, Suthamat 155 Øehulka, Pavel 152 Noberini, Roberta 105 Oeljeklaus, Silke 140, 185 Noborn, Fredrik 203 Oellerich, Michael 233 Nochi, Zahra 250 Oellerich, Thomas 130 Noda, Kenta 209 Oelrich, Johan 248 Nogueira, Fabio 171 Oetjen, Janina 166, 250, 261 Nohara, Takehiro 191 Ogata, Kosuke 251 Nolte, Hendrik 146, 192 Ogura, Toshinobu 220 Nolte, Hendrik Hannes 228 Oh, Ha Ram 171 Nombela, César 212 Oh, Kenneth 181, 258, 270 Nomura, Fumio 157, 203, 209, 216 Ohlsson, Camilla 269 Nonnis, Simona 198 Öhman, Tiina 182 Noor, Fozia 192 Ohnishi, Mihoko 191 Norais, Nathalie 209 Oh, Sohee 162 Noro, Erika 76, 206 Ohtsuki, Sumio 126, 265 Noronha, Melissa 226 Oishi, Masamichi 188 Novak, Petr 205 Oklu, Rahmi 227 Novoa-Herrán, Susana 125 Okuda, Shujiro 265 Novo, Jesus V. Jorrín 37 Oleaga, Ana 254 Novo, J. Jorrín 36 Olga, Saik 68
334 Olivan, Mireia 103 Osawa, Motoki 165 Oliva, Rafael 271 O’Shea, Carmel 113 Oliveira-Carvalho, Ana 129 Osinalde, Nerea 135, 181 Oliveira, E. 55 Osmolovskaya, Natalia 178 Oliveira, Eduardo Brant de 110 Osorio, Hugo 107 Oliveira, Eliandre 165, 271, 272 Ossenkoppele, Gert J. 154 Oliveira, Eliandre de 7, 10 Ossipova, Elena 202 Oliveira, Irene 263 Othman, Iekhsan 198 Oliveira, M. Margarida 152 Otte, David 236 Olmedo, María Isabel Ruiz 211 Otto, Markus 140, 233 Olsen, Jesper 134 Otto, Mike 124 Olsen, Jesper V 135 Oudgenoeg, Gideon 131 Olsson, Håkan 126 Ounissi, Marwa 194 Olsson, Tomas 234 Ovalles, Juan Gabriel 198 Olszanecki, Rafa 235 Overall, Chris 93 Omasits, Ulrich 268 Overall, Christopher 69, 110, 267 Omen, Gilbert 58 Overall, Christopher M. 263 Omenn, G. 58 Overbergh, Lut 183 Omenn, Gilbert 7, 142 Oya-Ito, Tomoko 145 Omenn, Gilbert S 143 Özp?nar, Aysel 179 Omenn, Gilbert S. 8 Özp?nar, Haydar 179 Omlin, Aurelius 107 Onkar, Amol 119 P Ono, Masaya 265 Oort, Frank A 131 Paape, Rainer 249 Oostrum, Jan Van 162 Pacelli, Consiglia 232 Openshaw, Matthew 184 Pacheco, Solange 168 Opperman, Kay 119, 129, 213 Padial, Luis R. 221, 223, 231 Oppermann, Madalina 177 Padmanaban, Arunkumar 148 Opsahl, Jill A. 272 Padró, Teresa 221 Oreiro, Natividad 200 Padyukov, Leonid 202 Orera, Irene 271, 272 Paek, Eunok 142 Orfanos, Zacharias 135 Páez, Carlos 111 Orfao, Alberto 108, 217 Pagans, Sara 133 Orlandi, Rosaria 124 Pagnoncelli, Dante 128 Ornellas, Antonio 129 Pagnozzi, Daniela 105, 139, 158, Orsolini, Ginevra 232 172, 210, 253 Ortea, Ignacio 198 Paik, Y. K. 58 Ortega-Martínez, Idoia 193 Paik, Young-ki 58 Ortega-Paino, Eva 248 Paik, Young-Ki 79, 268, 269 Ortiz, Alberto 140 Pailleux, Floriane 253 Ortiz-Casas, Mariana 211 Pais, Maria Salomé 177 Osaki, Tsukasa 225 Paiva, Carla 271
335 Pakshir, Keyvan 208 Park, Taesung 162 Pal, Debnath 151 Park, Young Mok 165 Palma, Camila 110 Park, Young-Mok 76 Palma, Sara De 258 Paron, Igor 246 Palma, Serena Di 194 Parra, Claudia 213, 214 Palmblad, Magnus 247 Parrinello, Claudio Attardo 271 Palmer, Martin 156 Parsons, Jeremy 260 Palmfeldt, Johan 148, 186, 237, 250 Partinen, Markku 234 Palmieri, Marta 108 Pascale, Delangle 147 Palmisano, Francesco 232 Pascual, A. 59 Palmisano, Giuseppe 134, 185 Pascual, Alberto 125 Palomba, Antonio 210 Pascual-Montano, Alberto 58, 271, 272 Palumbo, Federica 232 Pastushkova, Liudmila 269 Palviainen, Mari 171 Pastushkova, Ludmila 68 Pandey, Akhilesh 57, 121, 193 Pastushkova, Luidmila 269, 270 Pando-Robles, Victoria 60 Pataridis, Statis 191 Panic-Jankovic, Tanja 158, 161, 248 Patel, Bhavin 129 Panic, Tanja 144 Patel, Sandip 211 Pan, Tai-Long 146, 184 Pathe, Claudio 134 Pao-Chi 70 Paulitschke, Verena 109 Papa, Anna 209 Paus, Elisabeth 127 Papa, Sergio 232 Pauw, Edwin De 159, 198, 244 Pappa, Kalliopi I. 107 Pavesi, Giulio 190 Paradela, A. 48 Pavlukov, Marat 131 Paradis, Valerie 123 Pazos, Manuel 184 Parapatics, K. 110 Pedersen, Martin 185 Pardo, María 145 Pedersen, Thomas Lin 259 Parguiña, Andrés F. 140 Peeper, Daniel S. 197 Paricharttanakul, N. Monique 103 Peikert, Christian 185 Park, Byoung Chul 144, 240 Peitsch, Manuel 201 Park, Chan 172 Peitsch, Manuel C. 195 Park, Edmond Changkyun 138 Peláez-García, Alberto 104 Parker, Evan 190, 261 Peltoniemi, Hannu 259 Parker, Robert 162 Pengelley, Stuart 250 Park, Gun Wook 102 Peng, Kuan-Chieh 261 Park, Heejin 142 Peng, Mao 150, 191, 256 Park, Hyung Chul 111 Pengyuan, Yang 135, 204 Park, Hyung Soon 71 Penning, Renske 113 Park, Jisook 100, 230 Pennington, Stephen 113 Park, JiYoung 111 Penque, D. 33 Park, Jung-Hyun 143 Penque, Deborah 168 Park, Kevin 194, 242 Peral, Belén 147, 185 Park, Sung Goo 144, 240 Perales, Jonas 128, 188, 254
336 Percy, Andrew 50, 58, 251 Pham, Thang V. 153, 154, 266 Peredo, Anne Gonzalez de 163, 218, 264 Pham, T.V 141 Peredo, Anne Gonzalez De 181 Phanse, Sadhna 257 Pereira, Alexandre da Costa 224 Phan, Van Chi 153 Pereira, Denise 129 Phillips, Blaine 201 Peretz, David 181 Phillips, Leo 241 Perez-Andres, Martin 108 Phipps, Maude Elvira 198 Perez, Estela 269 Piatti, Patricia , 216 Pérez, Eva 272 Piaz, Fabrizio Dal 239 Perez-Garcia, Carmen 145 Picard, Guillaume 247, 249 Pérez-García, Fernando 192 Pich, Andreas 48 Perez, Juliana 205 Pichler, Peter 108, 263 Perez, Marina 129 Pickl, W.F 110 Pérez-Redondo, Rosario 192 Picotti, Paola 81, 194, 244 Pérez-Sánchez, Ricardo 254 Piening, Brian 195 Pérez-Sotelo, Diego 145 Pieroni, Luisa 271 Pérez-Yarza, Gorka 118, 193 Piero, Pucci 258 Perga, Simona 236 Piersma, Sander R 131, 153 Perkins, Neil D 133 Piersma, Sander R. 153, 154 Perkins, Simon 215, 217 Piersma, S.R. 141 Perl, Alexander E. 130 Pietrowski, Detlef 158 Pernemalm, Maria 106, 248 Pietrzik, Claus 136 Perry, Darryl 122 Pike, Ian 159 Perumal, Natarajan 160 Pilar-Orive, Javier 208 Pessione, Alessandro 174 Pilarsky, Christian 124 Pessione, Enrica 174 Pineau, Charles 17, 18, 20, 22 Peterman, Scott 194, 224 Ping, Peipei 79, 81 Peters, Christoph 131 Pinho, Joao P. C. 184 Peterson, Shane 181 Pinkse, Martijn 266 Petrak, Jiri 124 Pinna, Lorenzo A. 152 Petras, Daniel 33 Pino, Manuel M. Sánchez del 10, 272 Petrera, Agnese 54 Pino, Manuel M. Sánchez Del 120, 271 Petretto, Andrea 105, 180 Pino, Manuel Sánchez del 7 Pett, Christian 206 Pino, Manuel Sánchez Del 272 Petyuk, Vladislav 259 Pino, M.M. Sánchez del 31 Petzold, Christopher 263 Pinto, Luís 212 Peukert, Manuela 172 Pinto, Paula 168 Pfeifer, Heike 130 Pintor-Iglesias, Alejandra 200 Pfeiffer, Norbert 160 Piomboni, Paola 233 Pfister, David 119 Piras, Cristian 176, 187 Pflieger, Delphine 152 Pisanu, Salvatore 139, 158, 172 Pflug, Beth 99 Pison, Christophe , 191 Pham, Thang V 131 Pistoia, Vito 105
337 Pitarch, Aida 212 Poschmann, Gereon 147, 169 Pitt, Andrew 151, 185, 246 Pospisilova, Jana 124 Pittius, Nicolaas Gey v 149 Post, Harm 113 Planas, Antoni 251 Poto, Cristina Di 119, 120 Planatscher, Hannes 107, 161, 243, 262 Pottier, Charles 159 Plaschkes, Inbar 177 Pournaras, Jean-Antoine C 167 Plass, Christoph 196 Poverennaya, Ekaterina 190 Ploia, Cristina 198 Povlsen, Jonas A. 148 Plückthun, Andreas 246 Powers, Thomas W. 160 Plumel, Marine 192, 249, 250 Powlesland, Alex 44 Pochuev, Vladimir 270 Pozza, Elisa Dalla 108 Pockley, Graham 77, 109 Pradeep, Johnson 232 Poeta, Patrícia 212, 263 Prado, David Reigada 172 Poetsch, Ansgar 45 Prakash, Amol 224 Poetz, Oliver 17, 20, 50, 107, 122, 161, Pramana, Setia 210 164, 215, 243, 244, 256, 262 Prasad, T. S. Keshava 38, 121 Pogam, Sophie Le 255 Prasad, T.S. Keshava 121 Pohl, Chris 204 Prasad, TS Keshava 193 Pohl, Kerstin 129 Préfot, Petra 149 Pohl, Kerstin I 107 Preil, Simone A.R. 226 Polachini, Giovana 122 Prestel, Matthias 256 Polenakovik, Momir 114, 163 Pretti, Luca 172 Polishchuk, Roman 258 Pridatchenko, Marina L. 262 Polissi, Alessandra 176 Prieto, Gorka 265 Pol, Jaroslav 205 Profumo, Aldo 160 Polonskaia, Yana 220 Prosinecki, Vesna 168 Pomba, Constança 214 Przybylski, Michael 189 Pombo, Pilar Rodriguez 186 Puard, Vincent 169 Pomilio, Arianna 211 Puccini, Joey 133 Pompach, Petr 205 Pucci, Piero 258 Poncet, Pascal 204 Pudil, Radek 156 Pongsakul, Nutkridta 200 Puente, Patricia Fernández 268 Pontecorvi, Alfredo 156 Puerta, Angel 203 Pontén, Fredrik 191 Pugholm, Lotte 140 Pont, Laura 238 Pungor, Andras 161 Poon, Terence Chuen Wai 127 Pungor, András 161 Pope, Jackson 259 Punyarit, Phaibul 103 Pope, Phil 172 Puri, Neelu 126, 187 Popov, Igor 68, 116, 164, 216, 269 Purkayastha, Subhasish “Babu” 61 Porcelli, Anna Maria 270 Purnell, Phillip 141 Portelius, Erik 234 Puskarich, Michael 222 Posada-Ayala, Maria 140, 223 Putignani, Lorenza 48 Posch, Anton 258, 270 Puybasset, Louis 157
338 Puyol, María Jesus 137 Rafiee, Mahmoud-Reza 77 Pyatnitskiy, Mikhail A. 101 Rafiq, Qundeel 117 Pynn, Christopher 129, 164, 215 Raftery, Mark 166 Pynn, Christopher J. 244 Raghuraman, Bharath Kumar 266 Ragino, Yulia 220 Ramakrishna, T 169 Q Ramanjaneyulu, Gundimeda 193 Ramirez, Francisco 216 Qian, Wei-Jun 125 Ramírez-Torres, Adela 35 Qian, Xiaohong 245 Ramkrishna, T 182 Qi, Da 218 Ramona, Mayer 124 Qi, Jessica 262 Ramos, Elena 186 Qin, Chengfeng 136 Ramos-Fernandez, Antonio 183 Qing, Ying 242 Ramos, Yanilda 114 Qin, Jun 117, 119, 146, 181 Ramsauer, Christina 180 Qin, Weijie 245 Ramus, Claire 218 Qin, Xiaoyan 235 Ranbaduge, Nilini S. 163 Qin, Yannan 204 Ranganathan, Shoba 57, 75, 98, 105, Qiu, Xiao-Bo 136 259, 260 Quesada-Calvo, Florence 106, 159 Rangarajan, Annapoorni 151 Queseda-Calvo, Florence 198 Ranjbar, Mohammad Nezami 119 Quirino, Angela 210 Rao, Ch Mohan 169, 182 Qu, Jun 79, 130, 227 Rao, Srinivasa 204 Qundos, Ulrika 103 Rao, Weiqiao 246 Qu, Yang 227 Raschella, Giuseppe 113 Rasmussen, Lars M. 226 Raso, Cinzia 59 Rastogi, Anshu 125 R Rathi, Sonika 169, 182 Ravid, Rivka 165 Rabilloud, T. 37 Ravnsborg, Christian 217 Rabilloud, Thierry 7, 16 Ray, Kevin 99 Rackwitz, Tilmann 118, 124 Raymundo, Asuncion 196 Radhakrishnan, Aneesha 121 Ray, Sandipan 114, 115, 162, 211 Radhouani, Hajer 212 Ray, Sandpan 115 Radici, Lucia 124 Razavi, Morteza 249 Radi, Krisztina 189 Reales-Calderón, Jose Antonio 141, Radilov, Andrey 182 213, 214 Radman, Miroslav 123 Reddy, Lavakumar A 170 Radziwill, Gerald 135 Rees, Jon 222 Raekallio, Marja 171 Rees, Robert 77, 109 Raether, Oliver 249 Rego, Ignacio 200 Raffaghello, Lizzia 105 Rego, Joao Paulo 174
339 Regueiro-Vilar, Olga 203 Righetti, Pier Giorgio 61, 179 Rehulka, Pavel 156 Rinner, Oliver 161 Rehulkova, Helena 156 Rioseras, Beatriz 190 Reigada, David 173, 231 Ritter, Susan 194 Reimann, Lena 135 Rivera, Miguel 221 Reimer, Ulf 157 Riviello, Antonella 211, 234 Reinheckel, Thomas 131 Rizzuto, Antonia 122 Reis, Ana 185 Roa, Juan Carlos 121 Reis, Celso 107 Robbins, Phillip W. 207 Relaño, Sara 200 Robinson, Margaret 139 Rembovsky, Vladimir 182 Robles, Maria S. 153 Remes, Philip 245 Roca-Rivada, Arturo 145 Renard, Bernhard Y. 264 Rocca, Stefano 139 Renaut, Jenny 166 Rocha, Beatriz 199, 200, 245, 268 Ren, Jian Min 130 Rocha, Surza 188 Renkonen, Risto 259 Roche, Serge 125 Rennel, Emma 105 Rodet, Franck 180 Renuse, Santosh 121 Rodland, Karin D 125 Ren, Xiaojun 245 Rodriguez-Borlado, Luís 226 Resemann, Anja 249 Rodriguez-Cano, Teresa 145 Ressom, Habtom 119, 120 Rodríguez-Castro, Raquel 192 Restuccia, Umberto 109 Rodríguez-Cuevas, Sergio 120 Reubsaet, Leon 127, 138 Rodriguez-Garcia, Antonio 190 Reus, Inge De 153 Rodriguez, H. 30 Reventós, Jaume , 128 Rodriguez, Henry 30, 75 Reverter-Branchat, Gemma 128 Rodríguez, Isaac 184 Reviglione, Raffaella 236 Rodriguez, Jimmy 135 Rewerts, Christiane 218 Rodriguez, Madeline 114, 234 Reyes, Alejandro 196 Rodríguez, Rogelio 111 Reynisdottir, Gudrun 202 Rodríguez, Vanessa 125 Rezaei-tavirani, Mostafa 165 Roepstorff, P. 59 Rezeli, Melinda 81, 126, 226, 237, 272 Rogers, John 61, 119, 126, 129, 187, Rhee, Byoung Doo 185 213, 217 Rhim, Taiyoun 143, 152 Rogers, Lindsay 110 Rhode, Heidrun 265 Roget, K. 202 Riba-Garcia, Isabel 262 Roggio, Anna Maria 253 Ricciardi, Carlo 175 Rogovskaya, Nadezhda 182 Richter, Erik 183 Rogowska-Wrzesinska, Adelina 45 Ricketts, Bryon 130 Rohrer, Jeff 204 Rigat, Fabio 209 Rojas, Pamela Leal 121 Rigau, Marina 103, 128 Román-González, Sergio A. 211 Rigbolt, Kristoffer 123, 134 Romano, Roberto 122 Righetti, P.G 169, 178 Romero, Antonella Raffo 180
340 Romero-Rodríguez, Cristina 174 Rustarazo, María L. Valero 120 Roncada, Paola 37, 176, 187 Rutishauser, Dorothea 66, 178, 202 Rondas, Dieter 183 Ryu, Juyeon 240 Rönnelid, Johan 202 Rood, Brian 111 Roomp, Kirsten 148 S Roos, Andreas 235 Roozbeh, Jamshid 180 Saba, Julian 93, 119, 204, 205 Roque, Ana C. A. 151 Sabala, Lúcia 164 Röring, Michael 123 Sabido, Eduard 272 Rosa, Ana Barba De La 268 Sabidó, Eduard 103, 145, 231, 271 Rosa, Ana Paulina Barba de la 146, 171 Saccomano, Nicholas 122 Rosa, Isaac 140, 182, 225 Sacco, Rosario 122 Rosato, Antonio 232 Sachse, Frank 225 Roschitzki, Bernd 198 Saelens, Xavier 260 Rosello-Lleti, Esther 221 Saez-Rodriguez, Julio 151, 167 Rosenberger, George 250 Sagheb, Mohammad Mahdi 180 Ros, N. Fernnadez 131 Saharat, Kittirat 103 Rossi, Antonio 175 Saharkhiz, Mohammad Jamal 208 Rossi, François 218 Sahasrabuddhe, Nandini A. 121 Ross, Karen 135 Sahebekhtiari, Navid 186 Röst, Hannes L 250 Saibo, Nelson J.M. 152 Rothbauer, Ulrich 255, 256 Saik, Olga 257 Roumeliotis, Theodoros 118 Sajic, Tatjana 43, 65 Roux-Dalvai, Florence 163 Sakamoto, Dai 152 Roy, Marcia 232 Sakata, Maisa 174 Roytrakul, Sittiruk 155 Sakata, Yasushi 220 Rozemuller, Annemieke 237 Salas, Lucía María Lourido 199 Ru, Arnoud de 212 Salazar, Manuela Gesell 161, 215 Rubio-Sabugo, Eva 192 Salekdeh, Ghasem Hosseini 137 Rucavado, Alexandra 188 Salekdeh, S. Ghasem Hosseini 139 Rucevic, Marijana 210, 213 Salem, Gustavo 17, 18, 20 Rudashevskaya, E. L. 110 Salgueiro, Jéssica Silva 224 Rüetschi, Ulla 206 Salmerón, Jorge 120 Ruggles, Kelly 272 Salomon, Karen 243, 250 Ruilope, Luis M. 139, 222, 223 Salvi, Mauro 152 Ruiz, Cristina 272 Salvisberg, Cindy 167, 168 Ruiz-Romero, Cristina 199, 200, 245 Salzano, Anna Maria 113 Ruíz, Rosa Navarro 172 Salzet, Michel 122, 165, 180, 228 Runia, Tessel 237 Samaniego, Jaime 196 Ruppen, Isabel 128 Sampadi, Bharath 153 Ruprecht, Benjamin 103 Sampson, Samantha 149 Russell, Claire 159 Samuelson, John C 207
341 Samyn, Noortje 257 Sathe, Gajanan 121 Sánchez, Ángela de Águila 172 Sato, Ayako 138 Sanchez, Eladio 188 Satoh, Mamoru 157, 203, 209, 216 Sánchez-Gómez, Myriam 125 Sato, Misako 149 Sanchez, J. C. 56 Sato, Takashi 76, 206 Sanchez, J.C. 60 Savitski, Mikhail 241, 267 Sanchez, Jean Charles 100 Sawai, Setsu 216 Sanchez, Jean-Charles 9, 60, 72, 138, Saxena, Satya 262 148, 157, 160, 253, 268 Scacco, Salbvatore 232 Sanchez, Matilde 145 Scaloni, Andrea 113 Sánchez, Nuria 186 Schaab, Christoph 130 Sanchez, Paola 157 Schachterle, Steven 250 Sanchez, Pedro Luis 221 Schaefer, Jonas 246 Sanchez-Quiles, Virginia 134, 135 Schaeffer, Christine 218 Sanchez, Rosa 174 Schaeffer-Reiss, Christine 249 Sancho, Jaime 47, 271 Scheffer, George L 131 Sandberg, Ann-Sofi 248 Schepens, Bert 260 Sandim, Vanessa 129 Schepers, Eva 240 Sandin, Marianne 266 Schepmoes, Athena A. 125 Sandison, Mairi 151 Scherl, Alexander 241 Sand, Jannie 167 Schieffer, Bernhard 225 Sandow, Jarrod 100 Schieltz, David 222 Sangiao, Susana 190 Schiess, Ralph 20, 107 Sangro, B. 131 Schild, Hansjoerg 264 Sanna, M. 170 Schilling, Oliver 130, 131 Santamaría, Enrique 235, 269, 271 Schiltz, Odile 163, 168, 181 Santos, Ana I. 186 Schimmel, Joost 134 Santos, Hugo 212, 263 Schindler, Michael 183 Santos, Lilian 205 Schlalttner, Uwe 150 Santos, Tiago 263 Schlapbach, Ralph 146 Sanz, Antonio Serna 158 Schlegl, Judith 267 Sanz-Maroto, Aroa 246 Schlosser, Anders 169 Sanz-Nebot, Victoria 206, 238 Schmid, Rainer 158 Saoudi, Abdelhadhi 181 Schmidt 69 Saraswat, Mayank 259 Schmidt, Frank 211 Sardar, Krishnapada 228 Schmidt, Tannin 203 Sarg, Bettina 173 Schmidt-Weber, Carsten 183 Sarg, Herbert 173 Schmiegel, Wolff H. 169 Sargsyan, Ernest 148 Schmit, Pierre-Olivier 167, 243, 249, Sarracino, David 194, 224 250, 251 Sarrafzadeh, Asita 157 Schmitt, Pierre-Olivier 128 Sasaki, Kazuki 223, 225 Schnatbaum, Karsten 157, 267 Sastre-Oliva, Tamara 221, 231 Schneider, André 185
342 Schneider, Andrea 205 Segura, V. 272 Schneiderhan-Marra, Nicole 129, Seidel, Philipp 118, 124 262 Seijas, Iratxe 208 Schneider, Reinhard 148 Selevsek, Nathalie 146 Schneider, Richard 122 Sellami, Lyna 184 Schneider, Thomas 195, 201 Selley, Julian 262 Schnölzer, Martina 118, 124 Selzer, Stefan 158 Scholey, James 246 Semba, Richard 70, 117 Scholten, Arjen 191, 227 Semba, Richard D. 70 Schonthaler, Helia 128 Sendtner, Michael 229 Schors, Roel van der 237 Sénéchal, Hélène 204 Schott, Konstanze 150 Sengupta, Mohor 228 Schraen-Maschke, Susanna 237 Senko, Michael 245 Schreiber, Stuart L. 101 Sennels, Lau 182 Schrimpf, Sabine 175 Seo, Jong Bok 236 Schroetter, Andreas 236 Seong, Baik-Lin 172 Schultz-Knappe, Peter 215 Sequeiros, Tamara 103, 128 Schulz-Knappe, Peter 164, 244 Serchi, Tommaso 166 Schummer, Andreas 140 Seredina, A.V 197 Schuppe-Koistinen, Ina 18 Sergeant, Nicolas 237, 238 Schuppe-Koistrum, Ina 18 Serra-Batiste, Montserrat 236 Schutten, Rutger 141 Serra, Margarida 226 Schutzbier, Michael 129 Serrano, L. 42 Schvartz, Domitille 72, 138, 148, 268 Serrano, Luis 42 Schwartz, Peter 112 Serve, Hubert 130 Schwarzmeier, Josef 109 setarehaseman, Alireza 229 Schwenk, Jochen 17, 19, 65, 103, Setarehaseman, alireza 230 210, 223, 234 Setarehaseman, Alireza 102, 200, 229, Schwenk, Jochen M 19 230 Schwenk, Jochen M. 119, 159 Sethi, Manveen 30 Scielzo, Cristina 109 Seve, Michel 106, 112, 113, 150, 191 Scigelova, Michaela 124, 205 Sève, Michel 160 Scolyer, Richard 123 Seyboldt, Adrian 266 Scott, Ian 226 Seyfarth, Katrin 147 Scotton, Chiara 258 Seyfert, Sonja 113, 144, 158 Scrivens, James 189 Seymour, Sean 240 Seah, Lay Leng 123 Seymour, Sean L 60 Sebastiana, Mónica 177 Shabangu, Majahonkhe 210, 213 Seebun, Deeptee 194 Shadbolt, Paul 169 Seger, Svenja 236 Shah, Ajay M. 168 Seguchi, Osamu 223 Shahinian, Jasmin 130 Segura, Esperanza 145 Shah, Mohibullah 171 Segura, Juan A. 112 Shah, Veenita 114
343 Shaik, Asfa Alli 195 Siddiqui, Nikhat 188, 256 Shakir, Shakir 185, 186 Sidhu, Vishaldeep 257 Shalini, Sonia 133 Sidransky, David 121 Shambaugh, Joe 262 Sigismondo, Gianluca 200 Shan, Baozhen 266 Siino, Valentina 123 Shankar-Hari, Manu 168 Silajdžic, Edina 237 Shanker, Vijay 135 Silla-Castro, Juan Carlos 220 Shannon, Aoife 113 Silva, Dorinda M. 186 Shan, Qiang 117 Silva, Kleiton 205 Shan, Yichu 99 Silva, Marcia 212 sharifian, amirhossein 102, 230 Silvestre, Dario Di 176 sharifian, Amirhossein 229 Simó-Alfonso, Ernesto Francisco 179 Sharifian, Amirhossein 209, 229, 230 Simões, Tânia 168 sharifian, maryam 230 Simon, Marina 105 Sharifian, maryam 230 Simova-Stoilova, Lyudmila 174 Sharifian, Maryam 102, 180, 229, 230 Simpson, R.J 32 Sharifitabar, Mehdi 137 Sindona, Giovanni 115 Sharirian, Amirhossein 229 Sinha, Arunima 149 Sharma, Anil 155 Sirvent, Audrey 125 Sharma, Parveen 226 Sison-Young, Rowena 194 Sharma, Samridhi 115 Sitek, Barbara 169 Sharma, Sudhish 224 Skeie, Jessica 167 Shekari, Faezeh 139 Skeie, Jessica M. 71 Shekhar, Shubhendu 172 Sklenar, Jan 124 Shender, Victoria 131 Skogs, Marie 141 Shender, Viktoria 131 Sköld, C. Magnus 202 Shen, Huali 114, 216 Skoufos, John 173 Shen, Xiaomeng 130, 227 Skrbo, Nirma 123 Shen, Yuh-Chiang 237 Slade, Dea 251, 265 Shezifi, Dalia 258 Slagel, Joseph 264 Shibata, Yui 157 Slamnoiu, Stefan 189 Shibayama, Junko 225 Slany, Astrid 109, 199, 243 Shikanai, Toshihide 76, 206 Slapetova, Iveta 98 Shimada, Kenichi 101 Slovinska, Lucia 228 Shimojo, Naoki 157 Smagul, Aibek 224 Shirai, Katsunori 204 Smarggiasso, Nicolas 198 Shi, Tieliu 126 Smargiasso, Nicolas 106, 159, 244 Shi, Tujin 125 Smit, August 237 Shockcor, John 156 Smith, Gustav 226 Shoda, Junichi 206 Smith, Jacqueline 181 Shteynberg, David 12, 264 Smith, Julia 189 Sickmann, Albert 49, 224, 225 Smith, Kate 215, 216 Sidahmed-Adrar, Nazha 152 Smith, Richard D 125
344 Smit, Marjon A. 197 Souza, Gustavo de 149 Snovida, Sergei 119, 126 Sowmya 98 Snyder, Michael 8, 58, 195 Sowmya, Gopichandran 259 Soares, Arlete 171 Spadotto, Valeria 261 Soares, Emanoella 171 Spalloni, Alida 187 Soares, Marcia 211 Spät, Philipp 273 Sodeinde, Olugbemiro 210 Sperandeo, Paola 176 Söderholm, Sandra 182 Spickett, Corinne 185, 246 Soendergaard, Evo 140 Spinelli, Giulia 124 Soest, Remco van 162 Splendore, Maurizio 243, 250 Soest, Remco Van 247 Sresanga, Kitima 155 Sogabe, Maki 76, 206 Sridhar, Epari 115 Sogawa, Kazuyuki 157, 203, 216 Srikanth, Rapole 115 Soggiu, Alessio 81, 176, 187 Srinivasan, Alagarsamy 125 Sohn, Eun Hwa 133 Srinivasan, Krishnamachari 232 Solache, Alejandra 74 SriRamaratnam, Rohitha 101 Solanki, Hitendra S. 121 Srisanga, Kitima 155 Solari, Fiorella A. 38, 224 Srisomsap, Chantragan 103 Soldati, Denise 139 Srivastava, S. 37 Soldi, Monica 119, 200 Srivastava, Sanjeeva 69, 114, 115, Sollenberg, Ulla 157 162, 211, 233 Soltero, Nina 245 Srivastava, Shiv 125 Somja, Joan 106 Srivastava, Sudhir 125 Sommersdorf, Cornelia 122 Srivastava, Vaibhav 141 Sondergaard, Peter 242 Srzentic, Kristina 262 Sønderkær, Mads 117 Staal, Jerome 111 Song, Ehwang 120 Stachowicz, Aneta 235 Song, In Sung 185 Stadler, Charlotte 141 Song, Ji Hyun 201 Stadlmann, Johannes 265 Song, Qifeng 169 Stagljar, Igor 226 Song, Sangjin 143 Star, Alexandra 136 Song, Xiaomin 240 Starodubtseva, Natalia 164, 216 Soolingen, Dick van 212 Starr, Amanda 37, 201 Soon, Hyung 71 Starr, Amanda E. 226 Sorbello, O. 170 Stauch, Kelly 140, 141 Sorensen, Grith Lykke 169 Staunton, Lisa 113 Soria, Javier 157 Steegers, Eric 220 Soriano, Diana Ortiz 211 Steen, Hanno 82, 271 Sørlie, Therese 123 Stefania, Angelucci 234 Soste, Martin 194, 244 Steffen, Björn 130 Soubeyran, Philippe 133 Stehr, Andreas Møller 117 Soukupova, Magdalena 218 Steidel, Michael 255 Sousa, Marcos 226 Steinback, Michael 169
345 Steinbusch, Harry W 165 Sun, Xin 190 Steinhorst, Klaus 166 Sun, Yi 166 Steiniche, Torben S. 226 Sun, Zhi 211, 213 Stella, Maria 209 Suppanz, Ida 140 Stelzl, Ulrich 59 Surmann, Kristin 211 Stensballe, Allan 117, 182 Suski, Maciej 235 Stes, Elisabeth 260 Sutra, Jean-Pierre 204 Stevens, Stanley 144 Su, Tseng-Hsiung 149 Stickle, Dawn 244 Sutter, Delphine De 257 Stiles, Charles D. 125 Suttner, Kathrin 183 Stingl, Christoph 237 Suzuki, Nami 206 Stinzi, Alain 201 Svasti, Jisnuson 103 Stockwell, Brent R. 101 Svensson, Birte 166, 167 Stojko, Johann 188 Swart, Remco 244 Stoll, Dieter 129, 164, 215, 244 Sweetman, Gavain 241 Stoll, Monika 225 Swieringa, Frauke 224 Stoop, Marcel 237 Swift, Robert 122 Stranzl, Thomas 263 Switzar, Linda 247 Stromereder, Stefan 217 Syed, Nazia 121, 193 Struhárová, Iva 118 Syed, Parvez 162 Stühler, Kai 147, 169 Sykes, Erin 104, 123 Stuhlfauth, Juergen 255 Sykes, Erin K. 100 Stulik, Jiri 156 Szabo, Adrienn 110 Sturfelt, Gunnar 201 Sze, Siu Kwan 122 Suarez, Tatiana 157 Subbannayya, Tejaswini 121 Subbannayya, Yashwanth 121 Such-Sanmartín, Gerard 129 T Suckau, Detlev 124, 125, 249, 250 Tabacman, Eduardo 122 Sugihara, Yutaka 131, 252 Tabas, Daniel 125 Sugiyama, Naoyuki 152, 251 Tabolacci, Elisabetta 232 Sukegawa, Masako 206 Tadashi 74 Sukhih, Genady 164 Taechawattananant, Pasrawin 152 Sulman, Erik P. 272 Tahir, Ammar 109 Sulpizio, Marilisa 164, 211, 234 Tai, Hwan-Ching 232 Suna, Gonca 168 Tai, Jung-Hsiang 149 Sun, Aihua 245 Tajara, Eloiza 122 Sundberg, Mårten 37 Takagi, Shunsuke 251 Sundstrom, Jeffrey M. 71 Takagi, Tomohisa 145 Sung, Hye-Jin 163 Takahashi, Daisuke 176 Sun, Haidan 246 Takahashi, Takashi 99 Sun, Michael Xin 261 Takanen, Jenny Ottosson 74, 269 Sun, Warren Y. L. 234 Takashi 76
346 Takeda, Daisuke 191 Templin, Markus F. 256 Taki, Shintaro 101 Teng, Lei 120 Takizawa, Hirotaka 203 Tenni, Ruggero 175 Tamaki, Keiji 165 Tenzer, Stefan 127, 263, 264 Tambor, Vojtech 166, 167 Teplytska, Larysa 156, 236 Tamburro, Davide 159, 248 Teran, Luis 217 Tanae, Mirtes 205 Terfve, Camille 151 Tan, Binbin 76, 206 Teruuchi, Yoko 209 Tanca, Alessandro 48, 105, 158, 210 Teunissen, C.E. 141 Tan, Fengji 245 Teunissen, Charlotte E. 231 Tang, Hua 195 Thakur, Suman 169, 182 Tang, Wilfred 263 Thangavel, Hariprasad 115 Tani, Chiara 209 Thèlie, Aurore 176 Taniguchi, N. 46 Theodore 80 Taniguchi, Naoyuki 46, 78, 204 Theron, Laetitia 155 Tan, Kit-Yee 169 Thibault, P. 35 Tanno, Barbara 113 Thibault, Pierre 35, 128 Tan, Patrick 101 Thieblemont, Catherine 163 Tan, Shyh-Han 125 Thiery, Jean Paul 101 Tan, Sock Hwee 98 Tholey, Andreas 135, 136, 175 Tan, Sock-Hwee 105 Thomas 77 Tanzarella, Paola 232 Thome, Carolina 110 Tao, Nannan 250 Thomé, Carolina 110 Tao, Sheng Ce 206 Thompson, Andrew 61, 149, 218 Tao, Sheng-Ce 76 Thongboonkerd, Visith 200 Tapio, Soile 231 Threadgill, Graham 217, 247 Tarantino, Silvia 186 Tian, Yuan 120, 222 Tarasova, Irina A. 262 Tiberti, Natalia 157, 253 Tarasova, Nataliya K 202 Timmerman, Evy 257 Tarín, Nieves 221 Timperio, Anna Maria 270 Tascher, Georg 173, 192 Tintoré, Mar 231 Tate, Stephen 250 Titeca, Kevin 257 Taussig, Mike J 248 Titz, Bjoern 195, 201 Taus, Thomas 265 Tiys, Eugene 269 Tavera-Tapia, Alejandra 120 Tiys, Evgeny 257 Taverna, Elena 124 Tobes, Raquel 253 Tavernier, Jan 257 To, Chi-ho 270 Tedde, Vittorio 253 To, Chi Ho 150 Tedeschi, Gabriella 198 Todd, Matthew 262 Teis, David 173 Toerne, Christine von 147, 183, 231 Teixeira-Gomes, Ana-Paula 176 Togayachi, Akira 206 Tekiner 179 Tognotti, Danika 267 Templin, Markus 255 To, Ka Fai 127
347 Tokarska-Schlattner, Malgorzata 150 Tsai, Tsung-Heng 120 Toledo, Alejandro Gomez 203 Tsai, Wei-Chen 175 Tomasi, Giorgio 218 Tsangaris, George 106, 173 Tomioka, Azusa 76, 206 Tsang, Stephen H. 71 Tommasi, Nunziatina De 239 Tsou, Chih-Chiang 151 Tomonaga, Takeshi 115, 138, 149, 265 Tsuchida, Sachio 209, 216 Tonge, Dr. Robert 89 Tsunoda, Shin-ichi 101, 235 Tonge, Robert 259 Tsunoda, Shin-Ichi 220 Tonry, Claire 113 Tsuruyama, Tatsuaki 165 Toorn, Henk van den 77, 110, 142, 150 Tsutsumi, Yasuo 101, 220, 235 Topolcan, Ondrej 205 Tsybin, Yury O. 262 Toro, Javier De 190 Tu, Andrea 216 Torok, Zsolt 160 Tucher, Joanna 136 Torre-Escudero, Eduardo de la 254 Tudor, Catalina 135 Torre, Inmaculada de la 198 Tungpradabkul, Sumalee 155 Torres, Carmen 212 Tuñón, José 221 Torres, Sofia 100, 101, 104 Turck, Chris 156, 218, 236 Torres, Vukosava Milic 168 Turck, Natacha 157, 167, 168, 268 Torsetnes, Silje B. 127 Turner, Randi 70, 117 Toussaint, Bertrand 160 Turvey, Stuart 263 Towers, Mark 240 Tuveng, Tina 172 Toyoda, Masashi 76, 206 Tyan, Yu-Chang 116 Tozser, Jozsef 110, 160 Tzora, Athina 173 Traenkle, Bjoern 255 Tzouros, Manuel 255 Traenkle, Björn 256 Tran, Bao 161 Trede, Dennis 22, 166, 261 Tredup, Claudia 136 U Tregoat, Virginie 215 Uchiyama, Tatiana 174 Treindl, Fridolin 255, 256 Ueda, Koji 33 Trelis, Maria 139 Ueffing, M. 42 Tress, Michael 57 Ueffing, Marius 42, 70, 231 Trevisan-Herraz, Marco 191, 220 Uemura, Matsuo 176 Trifonova, Oxana 36, 145 Ugarte, Magdalena 186 Triviño, Juan Sebastian 137 Uhlen, Mathias 26, 57, 58, 74, 103, 210 Trocme, Candice 191 Uhlén, Mathias 74, 119, 141, 159, 191, Trocmé, Candice 160 223, 234, 239 Trugilho, Monique 254 Uhlen, Matthias 16 Trumpp, Andreas 196 Uhlén, Mattias 269 Tsagkari, Marouko 173 Ulcova-Gallova, Zdenka 181 Tsai, Chia-Feng 151 Ullán, Ricardo V 192 Tsai, Chih-Ming 149 Umemura, Hiroshi 216 Tsai, Shu-Han 212 Unwin, Richard 262
348 Unwin, Richard D 156 Vasso, Michele 258 Uppugunduri, Chakradhara RS 241 Vaudel, Marc 124, 224 Urbach, Serge 125 Vaz, Fátima 168 Urbani, A. 45 Vázquez, J. 44 Urbani, Andrea 77, 81, 176, 187, 271 Vazquez, Jesus 139, 222 Urh, Cernigoj 106 Vázquez, Jesús 7, 10, 44, 147, 184, 185, Urreta, Harkaitz 239 186, 191, 220, 271, 272 Uzzau, Sergio 105, 139, 158, 172, 210, Vázquez, Jesús López 226 253 Vea, Maria Ibanez 134 Veelen, Peter van 212 Vega, Francisco 227 V Végvári, Ákos 226, 237, 252, 272 Vélez, Paula 140, 225 Vaaje-Kolstad, Gustav 172 Veljkovic, Emilija 201 Vaca, Sebastian 218 Veneroni, Silvia 124 Vadakekolathu, Jayakumar 77, 109 Venkatesh, Apoorva 162 Vadali, Gouri 194, 224 Venkatraman, Vidya 79 Vadillo, Santiago 213 Venne, A. Saskia 224 Vainionpää, Mari 171 Ven, Peter F.M. van der 135 Vainio, Outi 171 Ventosa, Miguel 214 Vajrychova, Marie 166, 167 Ventroni, Tiziana 232 Valekova, Ivona 228 Ventura, Jose Luis Matín 220 Valent, Daniel 173 Venturini, Gabriela 224 Valente, Richard 128, 188 Ventz, Katharina 183 Valero-Galvan, Jose 174 Verderio, Paolo 124 Valle, Ylenia Da 111, 232 Verdier, Yann 256 Valsesia, Armand 144 Verhaert, Peter 9, 50, 266 Vandenbrouck, Yves 57 Verhee, Annick 257 Vanderklish, Peter 235 Verheggen, Kenneth 124 Vandermarliere, Elien 260 Verheul, Henk M.W. 153 Vanholder, Raymond 240 Verheul, Henk MW 153, 154 Vanmassenhove, Jill 240 Verigo, Elena 216 Vanquickelberghe, Emmy 257 Vermaere, Stijn 260 Vanscheeuwijck, Patrick 195 Vermeire, Tessa 260 Van, Sietze T 131 Verrastro, Ivan 185 Varano, Gabriele 190 Vertegaal, Alfred 134 Varano, Mariaconcetta 210 Viala, Didier 155 Varga, Gyorgy Marko 77 Vialas, Vital 213 Varghese, Rency 119, 120 Viana-Neto, Aderson 174 Varming, Kim 140 Vicente, Joana Lobo 218 Vasaturo, Michele 239 Vicente-Rodriguez, Marta 145 Vasco-Cárdenas, María F 192 Vidal, Oriol Vasco, Laura Soler 176 Vidal-Vanaclocha, Fernando 129
349 Vidic, Jana 248 Voelker, Uwe 215 Vies, Saskia van der 237 Voevoda, Mikhail 220 Vigy, Oana 125 Vogelsang, Maryann 194 Viken, Kevin 169 Vogelsang, Maryann S. 224 Vilanova, Mar 189, 236 Vojtìšek, Boøivoj 118 Vilaprinyó-Pascual, Sílvia 236 Volke, Daniela 210 Vilà-Rico, Marta 251 Völker, Uwe 161, 211, 225 Vilaseca, Marta 189, 236, 238 Vorweg, Lars 249 Vilholm, Ole 166 Vu, Long Dai 167 Villalun, MaryAnn 171 Vu, Thi Thu 185 Villani, Maria Elena 113 Vytásek, Richard 196 Villa-Piña, Tamara 186 Villard, Claude 184 Villar, Elena López 132 W Villar, Margarita 60, 253 Villarreal, Laura 128 Wada, Yoshinao 203 Villar-Vázquez, Roi 33 Waelkens, Etienne 183 Vinatier, Denis 122 Wagner, Anja 186 Vincenzoni, Federica 156, 232 Wagner, C. 110 Viner, Rosa 61, 119, 126, 177, 187, wagner, Erwin 128 204, 217, 263 Wagner, Mark 138 Vinh, Joelle 185, 186, 204, 256 Wagner, S.N. 110 Vinh, Joëlle 247 Wahlgren, Mats 210 Virginie, Brun 147 Waidelich, Dietmar 103 Visa, Neus 116 Wakabayashi, Masaki 152, 251 Viscomi, Carlo 186 Walch, Axel 166, 261 Vissers, Johannes 220, 229, 238, Waldemarson, Sofia 116 240, 259 Walker, Bruce 210 Vitale, Elena 190 Walker, Bruce D. 213 Vitali, Alberto 232 Walker, Michael 106 Vitek, Olga 21, 231 Wallner, Michael 180 Vit, Ondrej 124 Walter, Alexandre 266 Vittecoq, O. 202 Walter, Ulrich 224 Viturawong, Thanatip 256 Wan, Cuihong 152 Vivanco, F. 54 Wang, Dan 142 Vivanco, Fernando 7, 10, 54, 139, Wang, Fang 133 140, 222, 223, 239, 246, 271, 272 Wang, Jie-Siou 212 Vizcaino, Juan A. 7 Wang, Jing 136 Vizcaíno, Juan A. 262 Wang, Ming-Chuan 116 Vizcaino, Juan Antonio 60, 74 Wang, Minkun 120 Vlahou, Antonia 107, 118, 158 Wang, Mu 99 Vlasblom, James 257 Wang, Pei-Wen 146, 184 Vlasova, Maria A. 101 Wang, Penghao 123
350 Wang, Quanhui 157, 245, 246 Westermann, Stefan 129 Wang, Wansheng 111 Wetering, Marc van de 77, 110 Wang, Xiangdong 78, 132 Wheelock, A 45 Wang, Xiaolin 111 Whetton, Anthony 106 Wang, Xiaowei 112, 150 White, Melanie 79 Wang, Xiurong 204 Whitfield, Phillip 222 Wang, Xu 158 Wiborg, Ove 237 Wang, Yang 117 Wichert, Rielana 136 Wang, Yi 107, 119, 133, 146, 242 Widya, Marcella 218 Wang, Yi-Ting 151, 232 Wieczorek, Samuel 259 Wang, Youliang 117 Wiederkehr, Andreas 138, 177, 268 Wan, Jia 144, 158 Wiese, Heike 135 Ward 71 Wieslander, Elisabet 126 Ward, Malcolm 107, 159 Wiesner, Jan 249 Warnken, Uwe 118, 124 Wigmore, Cassandra 266 Warren, Robin 149 Wiker, Harald 149 Warscheid, Bettina 135, 140, 185 Wiking, Mikaela 141 Wasinger, Valerie 99, 112 Wilcox, Bruce 19, 20 Watanabe, Kennichi 239 Wilcox, Sheri 122 Watanabe, Koji 209 Wildgruber, Moritz 166 Watanabe, Regina 174 Wild, Peter 167 Waters, Karen 241 Wilhelm, Mathias 267 Watkins, Michael T. 227 Wilkes, Edmund 151 Watrous, Jeramie 21 Wilkey, Danny 268 Webb, Andrew 100 Willeit, Peter 168 Webhofer, Christian 218 Willetts, Matt 167 Weckwerth, W. 36 Williamson, Yulanda 222 Weckwerth, Wolfram 36, 37 Willows, Robert D 172 Weering, J.R Van 141 Wilson, Claire 133 Wee, Sheena 195 Wilson, Robert 246 Weilnböck, Lisa 109, 180 Wiltfang, Jens 76, 147 Weiss, Frederik 107, 161, 243 Wingrem, Christer 47 Welinder, Charlotte 126, 131, 252 Wingren, Christer 127, 201 Wells, Martin 14, 15 Winkler, Stephan 263 Welsch, Matthew E. 101 Winter, Martin 118, 124 Wen, Bo 245 Wisztorski, Maxence 122, 180 Wendler, Sindy 265 Wit, H De 141 Wendt, Chris 169 Wit, Meike de 129 Wenschuh, Holger 157 Wit, Meike De 131 Wen, Yao-Tseng 212 Witzel, Ini-Isabée 133 Werner, Thilo 241 Witzmann, Frank 138 Wessjohann, Ludgar 178 Woffendin, Gary 124, 205 Westerlind, Ulrika 206 Wojdyla, Katarzyna I. 250
351 Wojnar, David 266 Xui, Hui 216 Wolfensberger, Thomas J 167 Xu, Leilei 133 Wollscheid, Bernd 211, 268 Xu, Ningzhi 117 Wolters, Dominik 160 Xu, Ping 67, 117, 151 Wong, Chi-Huey 151 Xu, Shaohang 245 Wong, Nathalie 127 Xu, Xiaofei 180 Wong, Wai-ting 127 Xu, Zhongwei 117 Woo, Hye In 230 Woscholski, Rudiger 185 Wright, James C. 262 Y Wright, Phillip 201 Wu, Baolin 169 Yabuki, Masashi 239 Wu, Cathy 135 Yagi, Hiroaki 223, 225 Wu, Chaochao 125 Yagüe, Paula 190 Wu, Duojiao 132 Yakovleva, Maria 126, 131, 226 Wu, Hsin-Yi 149 Yamada, Mako 203 Wu, Jemma 240 Yamamoto, Keiko 150 Wu, Jingni 171 Yamamoto, Tadashi 74, 136, 150, Wu, Jiunn-Jong 212 191, 208, 215, 265, 270 Wünsch-Filho, Victor 122 Yanagisawa, Kiyoshi 99 Wu, Peng 181 Yang, Eva H. 123 Wu, Songfeng 151 Yang, Ganglong 204 Wu, Tung-Ho 184 Yang, Hao 162 Wu, Wei 108, 126 Yang, Jeong Soo 230 Wu, Yang-Chang 184 Yang, Juan 126 Wysocki, Vicki H. 163 Yang, Juncong 251 Yang, Mark 247 Yang, pengyuan 134, 242 X Yang, Pengyuan 67, 76, 107, 111, 114, 118, 133, 142, 203, 216, 242, 243, Xavier, Dylan 240 260 Xenarios, Ioannis 268 Yang, Rebbacah 227 Xiao, Di 212 Yang, Shuai 142 Xiao, Hua 204, 242 Yan, Guoquan 260 Xiaohui Liu 260 Yang, Wan Seok 101 Xiao, Ting 116 Yang, Xiao 117 Xia, Xia 119 Yang, Xu 213 Xie, Peng 133, 233 Yang, Zhang 204 Xie, Yingying 117 Yang, Zicheng 250 Ximenez-Embun, Pilar 128 Yan, Haiyan 112 Xiu, Youcheng 112 Yan, Hong-Young 175 Xuan, Yue 188, 194 Yan, Jian 242 Xu, Bo 136, 150, 215 Yankson, Kobena 104
352 Yan, Yinghua 134 Yao, Howard 120 Z Yaoita, Eishin 136, 150, 215 Yao, Jun 134 Zabrouskov, Vlad 245 Yasa, Isil 99 Zaccaria, Affif 251 Yates, John 150, 235 Zagato, Laura 220 Yazaki, Tatsuya 251 Zahedi, René 128, 235 Yen, Hsin-Yung 151 Zahedi, Rene P. 31 Yilmaz, Selen A. 163 Zahedi, René P. 224 Yi, Min-Jeong 116 Zahid, Saadia 233 Ying, Liu 245 Zahra, Meraj 188 Yin, Xiaoke 168, 227 Zaitsev, Alexey 225 Yin, Xuefei 216, 260 Zaloudíková, Marie 196 Yi, Tailong 117 Zambelli, Federico 190 Yılmaz, Sule 60 Zandian, Arash 234 Yongzhi, Guo 176 Zanon, Stephen 243 Yoo, Jong Shin 102, 165, 196 Zanotti, Lucia 198 Yoon, Jeehyun 71 Zaw, Thiri 240 Yoon, Jung-Hwan 164 Zee, Ate van der 100 Yoshida, Akihiko 100 Zeeman, Gerda 220 Yoshida, Maki 76, 206 Zeijl, Rene van 246 Yoshida, Yutaka 136, 150, 208, 215 Zelaya, Maria Victoria 235 Yoshikawa, Toshikazu 145 Zelaya, Victoria 269 Yoshioka, Yasuo 101, 220, 235 Zerweck, Johannes 157 Young, Iain 222 Zetterberg, Henrik 163, 231, 234 Yousefipour, Gholam Ali 229 Zeviani, Massimo 186 yousefipour, Golam hossein 230 Zgoda, Victor G. 101 Ytterberg, A. Jimmy 178, 202 Zhai, Linhui 117 Yuan, Huiming 239 Zhang, Chengcheng 224 Yuan, Min 257 Zhang, Chengpu 151 Yu, Fengjuan 150 Zhang, Chi 119 Yu, Hanjie 204 Zhang, Huaizhong 215, 218 Yu, Hongxiu 114, 118, 133 Zhang, Hui 66, 75, 155, 158 Yu, Hyeong Gon 162 Zhang, Huizhen 111 Yu, Jiekai 155 Zhang, Jianzhong 212 Yu, Jiyoung 111 Zhang, Jie 163 Yun, Hwan Sic 100 Zhang, Lei 142, 242 Yun, Sung Ho 138 Zhang, Lihua 99, 239, 244 Yun, Sung-Ho 177 Zhang, Na 120 Yu, Sujong 164 Zhang, Peixin 204 Yuzyuk, Tatiana 225 Zhang, Peng 234 Zhang, Pingbo 70, 217 Zhang, Pumin 67
353 Zhang, Shen 239 Zidkova, Lenka 156 Zhang, Shenyan 245 Ziemssen, Focke 70 Zhang, Wei 243, 248 Ziganshin, Rustam 131 Zhang, Xuewu 180 Zigrino, Paola 170 Zhang, Yan 76, 206, 262 Zi, Jin 157, 245 Zhang, Yang 216 Zimmer, Andreas 236 Zhang, Ying 76, 136, 150, 203, 215, Zingali, Russolina 129 242 Ziv, Tamar 177 Zhang, Yukui 99, 239, 244 Zoidakis, Jerome 107, 158 Zhang, Zhaolei 257 Zolghadr, Kourosh 256 Zhang, Zhen 75 Zolla, Lello 270 Zhan, Xianquan 112, 150 Zoltán, Nagy 106 Zhan, Xiaohan 112 Zomorodian, Kamiar 208 Zhao, Caifeng 134 Zorman, Sarah 150 Zhao, Fei 212 Zou, Jin 114 Zhao, Heng 99 Zubarev, Roman A. 178, 202 Zhao, Hui 136 Zubiri, Irene 140, 223 Zhao, Mindi 165, 175 Zwarthoff, Ellen C. 158 Zhao, Xiaolu 136 Zweynert, Friederike 124 Zhao, Yueqiang 224 Zhen, Bei 146 Zheng, Chaoya 235 Zheng, Haiyan 134 Zheng, Shu 155 Zheng, Weimin 142 Zhong, Qing 167 Zhong, Yaogang 204 Zhou, Baojin 245 Zhou, Cheng 118, 124 Zhou, Cong 106 Zhou, Lei 123, 165 Zhou, Ruo 245 Zhou, Wenyu 195 Zhou, Xi 136 Zhou, Xinwen 107 Zhou, Yang 246 Zhou, Yuan 244 Zhu, Fei 232 Zhu, Minzhi 204 Zhu, Weimin 74 Zhu, Xiujuan 136 Zhu, Yunping 151 Zibetti, Maurizio 229, 238
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