Serotonin (5-HT) and Its Role in the Treatment of Migraine
Molecular Mimicry of Anti-migraine Drugs with the Neurotransmitters, Dopamine (DA) & Serotonin (5-HT) and its Role in the Treatment of Migraine A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Science in Biochemistry In the School of Physical and Chemical Sciences at the University of Canterbury New Zealand By Nancy Joy University of Canterbury 2019 Acknowledgements Special thanks to my supervisor Prof. Ian. C. Shaw for all the discussions to support my thesis and fun lunch outs with our research group team members, who also supported me with molecular modelling guidance especially by Sam and Hector. Special mention to Rachel for taking the extra effort in booking our team meetings online David Zehms for helping me out in reviewing my thesis documents and Parvesh for the humorous talks and making our discussions fun filled moments. Key words Molecular mimicry, serotonin receptors, dopamine receptors, serotonin, dopamine, tyramine, monoaminergic neurons, migraine, migraine treatment, G protein-coupled receptors, neurotransmission, synaptic regulatory receptors and transporters, nociception, nociceptive afferents, neurovascular disorders, brain nuclei, trigeminal nervous system, trigeminal ganglion, vasoactive biochemicals and neuropeptides, insilico molecular modelling. Dedicated to the fond memories of my past professional life which shaped me to be who I am today, to my family & loved ones who have supported me through my struggles, to my aspirations to be a successful professional, and to my dreams:
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