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Mouse Anti-NBR1/FITC Conjugated antibody

SLM33384M-FITC

Product Name: Anti-NBR1/FITC Chinese Name: FITC标记的细胞迁移诱导蛋白19单克隆抗体 1A1 3B; 1A13B; Cell migration-inducing 19 ; KIAA0049; M17S2; Membrane component 17 surface marker 2; Membrane component surface marker 2; MIG 19; MIG19; Migration inducing protein 19; Alias: NBR 1; Nbr1; NBR1_HUMAN; Neighbor of BRCA1 gene 1; Neighbor of BRCA1 gene 1 protein; Next to BRCA1 gene 1 protein; Ovarian carcinoma antigen CA125; Protein 1A1-3B. Organism Species: Mouse Clonality: Monoclonal Clone NO: 9C3 React Species: ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 120kDa Form: Lyophilized or Liquid Concentration: 2mg/1mlwww.sunlongbiotech.com immunogen: Recombinant human NBR1 Protein Lsotype: IgG Purification: affinity purified by Protein G Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: The protein encoded by this gene was originally identified as an ovarian tumor antigen Product Detail: monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Function: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Subcellular Location: Cytoplasm. Cytoplasmic vesicle; autophagosome. Lysosome. Cytoplasm; myofibril; sarcomere; M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation.

Similarity: Contains 1 OPR domain. Contains 1 UBA domain. Contains 1 ZZ-type zinc finger.

Database links:

Entrez Gene: 4077Human

Entrez Gene: 17966Mouse

Entrez Gene: 303554Rat

Omim: 166945Human

SwissProt: Q14596Human

SwissProt: P97432Mouse

SwissProt:www.sunlongbiotech.com Q501R9Rat

Unigene: 277721Human

Unigene: 708158Human

Unigene: 784Mouse

Unigene: 94975Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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