Company Name Location Size Industry Type About/Specilization Website

Mass spectrometry and liquid chromatography, Pharmaceutical, drug discovery, proteomics, lipidomics and 1001-5000 metabolomics, Food safety & environmental analysis, Clinical AB SCIEX Framingham, MA employees Privately Held research & forensic toxicology http://www.absciex.com/ World-leading expertise in developing medicines that regulate the transforming growth factor beta (TGF-β) superfamily of Acceleron Pharma Cambridge, MA 51-200 employees Biotechnology Privately Held proteins http://www.acceleronpharma.com/ Cancer Metabolism, Biopharmaceuticals, Inborn Errors of Agios Pharmaceuticals Cambridge, MA 51-200 employees Pharmaceuticals Privately Held Metabolism http://www.agios.com/ Drug Development, Stapled Peptides, Biopharmaceuticals, Aileron Therapeutics Cambridge, MA 11-50 employees Pharmaceuticals Privately Held Chemistry http://aileronrx.com/

Alnylam Pharmaceuticals Cambridge, MA 51-200 employees Biotechnology Publicly Held Work in RNA interference, or RNAi http://www.alnylam.com/ AMAG markets an intravenous iron in the United States for the treatment of iron deficiency anemia in adult patients with AMAG Pharmaceuticals Lexington, MA 51-200 employees Pharmaceuticals Publicly Held Certifiedchronic kidney manufacturer disease (CKD)and supplier of high quality http://www.amagpharma.com/ biochemicals and reagent products for life science research American Bioanalytical Natick, MA 11-50 employees Biotechnology Privately Held and manufacturing applications http://www.americanbio.com/default.asp Consulting, Risk Management, Scientific Communications, Analgesic Solutions Natick, MA 11-50 employees Pharmaceuticals Privately Held Clinical Trials http://analgesicsolutions.com/ Anchor is a pre-clincal drug development company bringing First-in-Class approaches to allosterically modulate GPCRs Anchor Therapeutics Cambridge, MA 11-50 employees Biotechnology Privately Held toward treating a wide range of serious diseases. http://www.anchortx.com/#! Nanotechnology Drug Delivery, Enhanced Therapeutic Aphios Corp. Woburn, MA 11-50 employees Biotechnology Privately Held Products, Viral Inactivation http://www.aphios.com/#! ARIAD is a global oncology company focused on the discovery, development and commercialization of medicines ARIAD Pharmaceuticals Cambridge, MA 201-500 employees Pharmaceuticals Publicly Held to transform the lives of cancer patients. http://www.ariad.com/

AVEO Oncology Cambridge, MA 201-500 employees Pharmaceuticals Publicly Held Oncology http://www.aveooncology.com/ Berg Biosystems Framingham, MA 11-50 employees Research Privately Held Alterations in metabolism relate to disease onset http://www.bergbiosystems.com/index.html Offers high-throughput omics-based molecular profiling, biomarker validation, and regulated bioanalysis to accelerate Berg Dianogtics Framingham, MA 51-200 employees Biotechnology Privately Held Thedevelopment company of has molecular a deep pipeline therapeutics of early-stage and diagnostics technologies http://www.bergdiagnostics.com/#! in CNS diseases and metabolic diseases that complement its late-stage clinical trial activity in cancer and prevention of Berg Pharma Framingham, MA 51-200 employees Pharmaceuticals Privately Held chemotoxicity. http://www.bergpharma.com/index.html BIND Therapeutics Cambridge, MA 11-50 employees Biotechnology Privately Held Clinical-stage biopharmaceutical company http://www.bindtherapeutics.com/ 1001-5000 Idec Weston, MA employees Biotechnology Publicly Held World’s oldest independent biotechnology company http://www.biogenidec.com/ Analytucal and Biological testing in support of product characterization, lot release, and stability programs required Blue Stream Laboratories Cambridge, MA 11-50 employees Biotechnology Privately Held for pharmaceutical and biopharmaceutical development http://www.bluestreamlabs.com/ A clinical-stage biotechnology company, focuses on the development, manufacture, and marketing of therapies to bluebird bio, Inc. Cambridge, MA 51-200 employees Biotechnology Publicly Held treat various human diseases. http://www.bluebirdbio.com/index.php Develop highly selective drugs and combinations of drugs Blueprint Medicines Cambridge, MA 11-50 employees Biotechnology Privately Held against aberrant driver and resistance mechanisms http://www.blueprintmedicines.com/ Strategic Consulting, Clinical Research, Regulatory Affairs, Boston Biomedical Safety Oversight Committees, Biostatistics, and Data Associates (BBA) Northborough, MA 11-50 employees Medical Devices Privately Held CancerManagement research, Oncology, Drug development, Cancer stem http://www.boston-biomedical.com/ Boston Biomedical, Inc. Cambridge, MA 51-200 employees Biotechnology Privately Held cells http://www.bostonbiomedical.com/ A worldwide developer, manufacturer and marketer of Boston Scientific Natick, MA 10,001+ employees Medical Devices Publicly Held medical devices http://www.bostonscientific.com/us/index.html Cambridge Biomedical Inc. Boston, MA 11-50 employees Biotechnology Privately Held CRO & Diagnostic Laboratory Services http://www.cambridgebiomedical.com/ Cambridge Scientific Refurbished Lab Equipment, Used Lab Equipment, Biotech Products Watertown, MA 11-50 employees Biotechnology Privately Held TheEquipment first antibody-based combination immunotherapy http://www.cambridgescientific.com/welcome.aspx#! Celldex Therapeutics Needham, MA 51-200 employees Biotechnology Publicly Held Acompany new venture, formed through a partnership between http://www.celldextherapeutics.com/ Boston Children's Hospital and Life Technologies Corp Claritas Genomics Boston, MA 11-50 employees Biotechnology Privately Held The(started first in biopharmaceutical 2013). company dedicated to the http://www.claritasgenomics.com/ Constellation development of novel therapeutics in the emerging field of Pharmaceuticals Cambridge, MA 51-200 employees Pharmaceuticals Privately Held Epigenetics http://www.constellationpharma.com/ Courtagen Life Sciences, Inc. Woburn, MA 11-50 employees Biotechnology Privately Held Proteomics, genomics http://www.courtagen.com/#! Medical Devices, Surgical Tools, Medical Supplies, Mansfield, MA 10,001+ employees Medical Devices Publicly Held CubistRespiratory Pharmaceuticals Monitoring, is Vascular a rapidly Therapies growing, highly respected http://www.covidien.com/covidien/pages.aspx?page=Home biopharmaceutical company focused on researching, developing, and commercializing pharmaceutical products that address unmet medical needs in the acute care Lexington, MA 501-1000 employees Pharmaceuticals Publicly Held environment. www.cubist.com Daktari Diagnostics Cambridge, MA 11-50 employees Medical Devices Privately Held Global health, medical diagnostics http://www.daktaridx.com/

Diagnotics for All (DFA) Cambridge, MA 11-50 employees Biotechnology Nonprofit Research, Development, POC technology http://www.dfa.org/ Developing a new class of biosimilar products of complex Dragonfly Sciences, Inc Wellesley, MA 11-50 employees Biotechnology Privately Held monoclonal antibodies and soluble receptors http://www.dragonflysciences.com/#! Dyax's mission is to discover, develop, and commercialize innovative biopharmaceuticals for unmet medical needs while Dyax Corp. Burlington, MA 101-200 employees Drug Discovery Publicly Held delivering outstanding value to patients and stockholders. http://www.dyax.com/index.html Eleven Biotherapeutics Cambridge, MA 11-50 employees Biotechnology Privately Held Engineering protein-based drugs http://www.elevenbio.com/ Understanding the mechanisms of selective insulin sensitivity into a proprietary pipeline of peripherally-acting treatments Ember Therapeutics Boston, MA 1-10 employees Biotechnology Privately Held Lifefor metabolic Science Research, disease, including Drug Discovery Type 2 &diabetes Development, and obesity Lab http://www.embertx.com/ Filtration, Lab Water, Bioscience, Upstream & Downstream Bioprocessing, BioMonitoring, Lab Solutions, Life Sciences, EMD Millpore Billerica, MA 10,001+ employees Pharmaceuticals Publicly Held Process Solutions http://www.emdmillipore.com/ 1001-5000 Biotech, biotechnology, pharmaceutical, neurodegenerative EMD Serono Rockland, MA employees Biotechnology Privately Held diseases, fertility, metabolic endocrinology, oncology http://www.emdserono.com/en/index.html Strategic Partnering, Transaction Execution, Product Extera Partners Cambridge, MA 11-50 employees Biotechnology Privately Held Commercialization, BioPharma, MedTech http://www.exterapartners.com/#! Microfabrication, Microparticles, microRNA, Cytokines, Multiplex, Flow Cytometers, Cytometry, Bioassays, Firefly Bioworks Cambridge, MA 11-50 employees Biotechnology Privately Held Biomarkers, Molecular Diagnostics, Inflammation, Cance http://www.fireflybio.com/#! Building a robust pipeline of transformative cancer therapeutics directed in areas such as tumor metabolism, FORMA Therapeutics Watertown, MA 51-200 employees Biotechnology Privately Held epigenetics and protein-protein interactions http://formatherapeutics.com/ Molecular information, cancer genomics, next-generation Foundation Medicine Cambridge, MA 51-200 employees Biotechnology Privately Held sequencing, and precision medicine http://www.foundationmedicine.com/#! Genocea is developing a new class of human vaccines based on a revolutionary platform for the rapid discovery of Genocea Biosciences Cambridge, MA 11-50 employees Biotechnology Privately Held antigens that induce T cell immunit http://www.genocea.com/ Enables life science companies to search worldwide patent GenomeQuest Inc. Westborough, MA 11-50 employees Biotechnology Privately Held literature for DNA and other biological sequences http://www.genomequest.com/

Genzyme Cambridge, MA 10,001+ employees Biotechnology Publicly Held Focus on rare diseases and multiple sclerosis www.genzyme.com Ginkgo Bioworks Boston, MA 11-50 employees Biotechnology Privately Held Synthetic biology, biological engineering http://ginkgobioworks.com/ Pioneers in the field of DNA sequencing technology for the GnuBIO, Inc. Cambridge, MA 11-50 employees Biotechnology Privately Held Thediagnostic company’s and scientific affordable research pre-pregnancy markets test utilizes an http://gnubio.com/ advanced DNA sequencing technology to screen for multiple Good Start Genetics, Inc. Cambridge, MA 51-200 employees Biotechnology Privately Held H3genetic Biomedicine disorders. Inc. is a privately-held, uniquely-structured http://www.goodstartgenetics.com/#! drug discovery enterprise that is integrating insights from cancer genomics with innovative capabilities in synthetic chemistry and tumor biology to generate novel small-molecule H3 Biomedicine Cambridge, MA 51-200 employees Pharmaceuticals Privately Held drugs to treat cancer. http://www.h3biomedicine.com/ 5001-10,000 Molecular Diagnostics, Breast Imaging and Intervention, Hologic, Inc. Bedford, MA employees Medical Devices Publicly Held Gynecologic Health Solutions, Skeletal Imaging http://www.hologic.com/en/` Engaged in the discovery and development of drugs for the Idenix Pharmaceuticals Inc. Cambridge, MA 201-500 employees Pharmaceuticals Publicly Held treatment of human viral and other infectious diseases http://www.idenix.com/index.html Investigate disease biology and therapeutic efficacy at the Immuneering Corporation Cambridge, MA 11-50 employees Biotechnology Privately Held cellular and molecular level http://www.immuneering.com/#! Innovative small molecule drug discovery and development, specialization in Oncology, small molecule, fully integrated, Infinity Pharmaceuticals Cambridge, MA 51-200 employees Pharmaceuticals Publicly Held inflammation. http://www.infi.com/ Interlukin Genetics Waltham, MA 11-50 employees Biotechnology Publicly Held IronwoodGenetic Testing, Pharmaceuticals BioMarkers is an entrepreneurial http://ilgenetics.com/#! pharmaceutical company committed to two goals: delivering differentiated medicines to patients and delivering value to our shareholders. We believe achieving those goals is incredibly difficult, and we’re looking for people who are up Ironwood Pharmaceuticals Cambridge, MA 201-500 employees Pharmaceuticals Publicly Held to the challenge. http://www.ironwoodpharma.com/ Knome Inc. Cambridge, MA 51-200 employees Biotechnology Privately Held UtilizesHuman awhole proprietary genome technology interpretation for engineering novel http://www.knome.com/#! biochemistry in microorganisms for the sustainable Manus Biosynthesis Cambridge, MA 11-50 employees Biotechnology Privately Held manufacture of chemicals http://www.manusbio.com/#!

Merrimack Pharmaceuticals Cambridge, MA 201-500 employees Biotechnology Publicly Held LifeOncology, science Network company Biology dedicated to providing innovative http://www.merrimackpharma.com/ function-based prognostic tests that enable physicians, payers, and patients to make informed treatment choices that provide optimal outcomes for patients while minimizing morbidities Metamark Genetics Cambridge, MA 11-50 employees Biotechnology Privately Held and costs. http://www.metamarkgenetics.com/#! Engages in the research, development, and commercialization Millennium of medicines for the treatment of cancer in the United States Pharmaceuticals, Inc. Cambridge, MA 501-1000 employees Pharmaceuticals Privately Held and internationally http://www.millennium.com/Default.aspx Therapeutics Cambridge, MA 11-50 employees Biotechnology Privately Held Moderna is pioneering messenger RNA Therapeutics http://www.modernatx.com/ Biotechnology company with a product pipeline of both Momenta Pharmaceuticals Cambridge, MA 201-500 employees Biotechnology Publicly Held complex mixture generic and novel drugs http://www.momentapharma.com/

OPKO Diagnostics, LLC Woburn, MA 201-500 employees Medical Devices Publicly Held Point-of-Care Products for Medical Diagnostics http://www.opko.com/ Paloma Pharmaceuticals Inc Jamaica Plain, MA 11-50 employees Pharmaceuticals Privately Held Early stage drug development company http://www.palomapharma.com/cfiles/home.cfm PanGenX Newton, MA 11-50 employees Biotechnology Privately Held Collaboration between geneticists and computer scientists http://www.pangenx.com/#! Scientific informatics, diagnostics, drug discovery, biomedical 5001-10,000 & life science research, food safety and testing, environmental PerkinElmer, Inc. Waltham, MA employees Biotechnology Publicly Held Multiplextesting & monitoringqPCR, Companion Diagnostics, Molecular http://www.perkinelmer.com/ PrimeraDX, Inc. Mansfield, MA 51-200 employees Biotechnology Privately Held ClinicalDiagnostics Operations, Clinical Monitoring, Clinical Data http://www.primeradx.com/ Management, Database Programming, Biostatistics, Statistical Programming, Medical Writing, Regulatory Submissions, Electronic Data Capture (EDC), NDA & EU Regulatory PROMETRIKA, Inc. Cambridge, MA 11-50 employees Biotechnology Privately Held Submissions, Data Monitoring Committee (DMC) http://www.prometrika.com/#! Proteostasis Therapeutics, Inc. Cambridge, MA 11-50 employees Biotechnology Privately Held Biotechnology, novel small molecules, platform capabilities http://www.proteostasis.com/ Quanterix Lexington, MA 11-50 employees Biotechnology Privately Held Ultrasensitive immunoassay, digital ELISA http://www.quanterix.com/ Product development: Rapid automated detection and enumeration, Rapid Sterility Testing, Rapid Environmental Rapid Micro Biosystems Bedford, MA 11-50 employees Biotechnology Privately Held Monitoring, Rapid Water and Bioburden Testing http://www.rapidmicrobio.com/ Life sciences, biologics manufacturing, bioprocess RepliGen Corporation Waltham, MA 51-200 employees Biotechnology Publicly Held CNSdevelopment, disorders, chromatography Positive and Negative Allosteric Modulators http://www.repligen.com/ Sage Therapeutics Cambridge, MA 11-50 employees Biotechnology Publicly Held (PANAM) http://www.sagerx.com/ Biotechnology, Bioillumination Platform, Microbiology, Sample6 Boston, MA 11-50 employees Biotechnology Privately Held Synthetic Biology, Food Safety http://sample6.com/#! Cambridge, MA 51-200 employees Biotechnology Publicly Held Focus on RNA-based therapeutics http://www.sareptatherapeutics.com/ Cytokine Research Services, Biomarker Measurement, Kinase Analysis, Bioassay, Diagnostics, In-Vivo Cancer Models, Cell Culture, Protein Purification, Lead Drug Discovery & SBH Sciences Natick, MA 11-50 employees Biotechnology Privately Held Optimization, ELISA & Multiplex Services http://www.sbhsciences.com/index.asp Critical Raw Materials, Formulated Clinical Chemistry Sekisui Diagnostics Lexington, MA 51-200 employees Medical Devices Publicly Held Reagents, Point of Care Rapid Diagnostic Tests http://www.sekisuidiagnostics.com/ Selecta Biosciences Watertown, MA 11-50 employees Biotechnology Privately Held Clinical-stage biotechnology company http://www.selectabio.com/ Systems Diagnostics (SysDx), Research in: SystemsBiology, Selventa Cambridge, MA 11-50 employees Biotechnology Privately Held AMolecular publicly Toxicology,held biopharmaceutical Personalized company Healthcare with http://www.selventa.com/ headquarters, research and development facilities in Synageva BioPharma Corp. Lexington, MA 51-200 employees Biotechnology Publicly Held Lexington, MA. http://www.synageva.com/ Laboratory services, diagnostics, autism spectrum disorders, Synap Dx Lexington, MA 11-50 employees Medical Devices Privately Held Agene biopharmaceutical expression company focused on discovering, http://www.synapdx.com/ developing, and commercializing small molecule drugs to extend and enhance the lives of patients with severe medical Synta Pharmaceuticals conditions, including cancer and chronic inflammatory Corp. Lexington, MA 51-200 employees Pharmaceuticals Publicly Held diseases http://www.syntapharma.com/index.php T2 Biosystems Lexington, MA 11-50 employees Biotechnology Privately Held Sepsis, Hemostasis, Infectious Diseases, In-vitro diagnositcs http://www.t2biosystems.com/ Assay Development and Validation, Bioassay, Sample TGA Sciences, Inc. Medford, MA 11-50 employees Biotechnology Privately Held AnalyticalCollection Instruments,Kits, in vivo studiesLaboratory Supply Chain Programs http://www.tgasciences.com/#! and eCommerce, Laboratory Equipment, Lab Services, Thermo Fisher Scientific Waltham, MA 10,001+ employees Research Publicly Held Specialty Diagnostics http://www.thermofisher.com/global/en/home.asp Gene engineering, protein research, and antibody productin USAL Inc. Roslindale, MA 11-50 employees Biotechnology Privately Held Afor biopharmaceutical research and clinical company use focused on discovering and http://www.usailinc.com/index.html developing novel drugs that selectively target cancer stem Verastem, Inc. Cambridge, MA 11-50 employees Biotechnology Publicly Held cells. http://www.verastem.com/ Structure-based Drug Design, Small Molecule, Solid Oral 1001-5000 Dosage Form, Continuous Processing, Hepatitis C, Cystic Cambridge, MA employees Pharmaceuticals Publicly Held Fibrosis, rheumatoid arthritis, equal employment opportunity http://www.vrtx.com/ 1001-5000 UPLC, HPLC, Chromatography, Mass Spectrometry, Waters Corporation Milford, MA employees Research Publicly Held Informatics, Thermal Imaging, Chemistry http://www.waters.com/waters/home.htm?locale=en_US Zalicus has a portfolio of proprietary clinical-stage product candidates targeting pain, including Z160, an N-type calcium channel blocker for chronic neuropathic pain and Z944, a T- Zalicus Inc. Cambridge, MA 11-50 employees Biotechnology Publicly Held type calcium channel blocker for acute and inflammatory pain. http://www.zalicus.com/#! Ziopharm Oncology Boston, MA 51-200 employees Pharmaceuticals Privately Held Discovery and development of new cancer therapies http://www.ziopharm.com/#!