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NCEPOD Reports, Simple Are the Components of Good First Line Treatment, Because at Root the Themes Are Familiar

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NCEPOD Reports, Simple Are the Components of Good First Line Treatment, Because at Root the Themes Are Familiar Just Say Sepsis! A review of the process of care received by patients with sepsis Improving the quality of healthcare Just Say Sepsis! A review of the process of care received by patients with sepsis A report by the National Confidential Enquiry into Patient Outcome and Death (2015) Compiled by: APL Goodwin FRCA FFICM – Clinical Co-ordinator Royal United Hospital Bath NHS Trust V Srivastava FRCP (Glasg) MD – Clinical Co-ordinator King’s College Hospital NHS Foundation Trust H Shotton PhD – Clinical Researcher K Protopapa BSc Psy (Hons) – Researcher A Butt BSc (Hons) – Research Assistant M Mason PhD – Chief Executive The study was proposed by: UK Sepsis Trust – Dr Ron Daniels and Public Health England – Dr Imogen Stephens The study was commissioned by the Healthcare Quality Improvement Partnership (HQIP) on behalf of NHS England, NHS Wales, the Northern Ireland Department of Health, Social Services and Public Safety (DHSSPS), the States of Guernsey, the States of Jersey and the Isle of Man government. The authors and Trustees of NCEPOD thank the NCEPOD staff for their work in collecting and analysing the data for this study: Robert Alleway, Donna Ellis, Heather Freeth, Dolores Jarman, Kathryn Kelly, Kirsty MacLean Steel, Nicholas Mahoney, Eva Nwosu, Neil Smith and Anisa Warsame. Contents Acknowledgements 3 Foreword 5 Principal recommendations 9 Introduction 11 1 – Method and data returns 13 2 – Organisational data 17 Key findings 33 3 – Patient population and pre-hospital care 35 Case study 1 47 Case study 2 48 Case study 3 50 Key findings 55 4 – Admission to hospital 57 Case study 4 60 Key findings 61 5 – Patients with hospital-acquired infections 63 Key findings 66 6 – First identification of sepsis 67 Case study 5 70 Case study 6 72 Case study 7 76 Key findings 76 7 – Initial management of sepsis 77 Case study 8 87 Case study 9 92 Key findings 94 8 – Complications of sepsis and discharge planning 95 Key findings 104 9 – Overall quality of care 105 Recommendations 107 Summary 109 References 111 Appendices 115 1 - Glossary 115 2 - Existing sepsis information, templates and tools 117 3 - The role and structure of NCEPOD 118 4 - Participation 120 Acknowledgements Back to contents This report, published by NCEPOD, could not have been Dr Chris Custard, Consultant in Acute & General achieved without the support of a wide range of individuals Internal Medicine who have contributed to this study. Ms Beryl De Souza, Consultant Plastic Surgeon Dr Paul Dean, Consultant in Anaesthesia and Intensive Our particular thanks go to: Care Medicine Mrs Mary Edwards, Critical Care Outreach Team Lead The Study Advisory Group who advised NCEPOD Dr Rhian Edwards, Consultant in Anaesthesia and on the design of the study: Intensive Care Medicine Ms Susan Bracefield, Critical Care Nurse Ms Karin Gerber, Clinical Nurse Specialist, Critical Professor Gordon Carlson, Consultant Surgeon Care Outreach Dr Niall Collum, Consultant in Emergency Medicine Ms Carmel Gordon, Critical Care Outreach Lead Dr Alaric Colville, Consultant in Microbiology Ms Patricia Guilfoyle, Critical Care Outreach Sister Professor Matthew Cooke, Consultant in Ms Rhona Hayden, Matron Critical Care Outreach Services Emergency Medicine Lt Col Paul Hunt, Military Consultant in Emergency Medicine Dr Ron Daniels, Consultant Intensivist Dr Stephen Hutchinson, Consultant in Anaesthesia and Mr Chris Hancock, Programme Manager, NHS Wales Intensive Care Medicine Sepsis Programme Dr Phil Jacobs, Consultant Physician in Acute and Mr Eddie Morris, Consultant Obstetrician and Gynaecologist General Medicine Professor Sebastian Lucas, Consultant Pathologist Mr Sunjay Kanwar, Consultant General and Upper Mr Dermot O’Riordan, Consultant Surgeon Gastrointestinal Surgeon Dr Marilyn Plant, General Practitioner Dr Liza Keating, Consultant Intensive Care and Dr Christopher Roseveare, Consultant Physician Emergency Medicine Dr Andrew Stacey, Consultant in Microbiology Dr Jeff Keep, Consultant in Emergency Medicine Dr Imogen Stephens, Consultant in Public Health Medicine & Major Trauma Ms Catherine White, Patient Representative, ICUSteps Dr Alastair Keith, Clinical Fellow in Anaesthesia Dr Ian Kerslake, Consultant in Anaesthesia and Intensive The Reviewers who peer reviewed the cases: Care Medicine Mr John Abercrombie, Consultant General Surgeon Dr Patrick Lillie, Consultant in Acute Medicine and Dr Julie Andrews, Consultant in Medical Microbiology Infectious Diseases and Virology Dr Stephen Luney, Consultant Neuroanaesthetist Ms Esme Blyth, Sepsis Nurse and Critical Care Dr Cliff Mann, Consultant in Emergency Medicine Outreach Nurse Dr Chakri Molugu, Consultant in Acute and General Dr Caroline Burford, Senior Trainee in Acute and Intensive Medicine Care Medicine Dr Nick Murch, Consultant in Acute Medicine Dr John Bye, General Practitioner Mr Julian Newell, Emergency Nurse Practitioner Dr Tim Collins, Acute Care Consultant Nurse Dr Emmanuel Nsutebu, Consultant in Infectious Diseases Dr Ben Creagh-Brown, Consultant Physician in Intensive and General Internal Medicine Care and Respiratory Medicine Dr Tim Nutbeam, Consultant in Emergency Medicine Ms Nicola Credland, Specialist Lecturer Practitioner Dr Stuart Nuttall, Consultant in Emergency Medicine 3 ACKNOWLEDGEMENTS Dr Helena Parsons, Consultant in Microbiology Ms Catherine Plowright, Consultant Nurse in Critical Care Dr Lee Poole, Consultant in Anaesthesia and Intensive Care Medicine Mr Suman Shrestha, Advanced Critical Care Nurse Practitioner Dr Hannah Skene, Consultant in Acute and General Medicine Dr Catherine Snelson, Consultant in Critical Care and Acute Medicine Dr Mike Spivey, Consultant in Intensive Care and Anaesthesia Dr Shiva Sreenivasan, Consultant in Acute and General Medicine Dr Jonathan Stacey, General Practitioner Dr Pius Tansinda, Consultant in Nephrology Dr Jerry Thomas, Consultant in Anaesthesia and Intensive Care Medicine Dr Madhankumar Vijaya Kumar, Consultant in Anaesthesia and Intensive Care Medicine Dr Rosanne Wrench, General Practitioner Mr Martin Wiese, Consultant Emergency Physician Thanks also go to all the NCEPOD Local Reporters, NCEPOD Ambassadors, Study Specific Contacts and the Clinicians who took the time to complete questionnaires. 4 Foreword Back to contents This NCEPOD study addresses a huge subject, which sets also tell us that in a significant number of cases the culprit it aside from those of our reports that have focused on now turns out to be viral or fungal, although that did not Cinderella topics, parts of the NHS that have been previously seem to be so in the cases we studied. overlooked. Sepsis, by which we mean the systemic inflammatory response to microbial infection, causing The laity are well aware that medicine is constantly evolving damage to organs then shock and ultimately death is a as new interventions are introduced. To discover that common problem: the international prevalence is estimated1 the bugs are doing the same takes a bit of getting used at 300 per 100,000, suggesting that there are around to: these are not necessarily bacteria that are developing 200,000 cases a year in the UK alone. To put this into new resistances or sharing their resistances to individual the context of our recent studies, there are around 5,500 antibiotics through species-jumping, although no doubt lower limb amputations, a similar number of subarachnoid that is adding to the problem. Here the nature of the haemorrhages, 8,000 or so aortic aneurysms, 9,000 deaths disease is becoming both more complicated and more from alcohol-related liver disease, 10,000 tracheostomies elusive. Critics must acknowledge that medicine has never and 11,600 bariatric procedures performed per year. Sepsis been easy and here it is getting more difficult. eclipses even the 90,000 patients treated for gastrointestinal bleeding. Finally, this is a significant study precisely because the importance of the issue has been recognised by others, Sepsis is important because it is a major cause of avoidable including ongoing work at NHS England and the ‘1000 Lives death in our hospitals. According to the same source1, Plus’ national improvement programme in Wales. The role the current mortality from sepsis is greater than that from of this report is not to draw attention to an unrecognised myocardial infarction in the 1960’s. We are told that the problem but to examine an acknowledged problem much survival from sepsis-induced hypotension is over 75% if it more closely than before and to demonstrate how these is recognised promptly, but that every hour’s delay causes patients are being let down. Here you will learn the nature of that figure to fall by over 7%,2 implying that the mortality the malady and the remedies our peer reviewers prescribe. increases by about 30%. Since we found that longer delays in treatment are commonplace, the results of this study The first thing that strikes me is that being a big subject should make everyone sit up and take notice. has enormous advantages. Since the problem is so common, the NHS can justify providing appropriate Sepsis is also important because it has become more resources to cater for it. That is not as easy as it sounds difficult to manage. It used to be viewed as a disease because it also commonly presents in the community. invariably caused by gram-negative bacteria, but the picture Nevertheless it is straightforward to provide the protocols has changed over the last 30 years. In over 60% of the cases and resources needed in a network across the nation. If it we reviewed, no pathogen was ever identified
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