Rabbit Anti-Human Phospho-Shb (Y246) Polyclonal antibody (DPABH-01360) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit Polyclonal to Phospho-Shb (Y246).

Specificity This antibody detects endogenous levels of Shb only when phosphorylated at Y246.

Target Phospho-Shb

Immunogen Synthesized peptide derived from human Shb around the phosphorylation site of Y246.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human, Mouse

Purification This antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate Unconjugated

Applications WB, ELISA

Molecular Weight 55 kDa

Format Liquid

Concentration Lot specific

Buffer PBS containing 50% glycerol and 0.5% BSA

Preservative 0.02% Sodium Azide

Storage Store at -20°C, and avoid repeat freeze-thaw cycles.

Warnings For research use only.

BACKGROUND

Introduction Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Keywords SHB;Src homology 2 domain containing adaptor protein B;SHB (Src homology 2 domain containing) adaptor protein B;SHB adaptor protein (a Src homology 2 protein);SH2 domain- containing adapter protein B;SHB adaptor protein (a Src homology 2 protein);SHB (Src homology 2 domain containing) adaptor protein B;bA3J10.2;RP11-3J10.8

GENE INFORMATION

Entrez ID 6461

UniProt ID Q15464

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved