Prefrontal Mechanisms Underlying Sequential Tasks by Feng-Kuei
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Erin L. Rich, MD, Phd Tel
Erin L. Rich, MD, PhD tel. (212) 824-9304 Hess CMS Building [email protected] Room 10-115 1470 Madison Ave New York, NY 10029 Professional 2017 – present Assistant Professor (Tenure-track), Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai Date of appointment: April 1, 2017 2015 – 2017 Assistant Project Scientist, Helen Wills Neuroscience Institute, University of California, Berkeley 2014 – 2017 Affiliate Researcher, Department of Neurological Surgery, University of California, San Francisco 2010 – 2015 Post-doctoral Fellow, University of California, Berkeley Mentor: Joni Wallis, PhD 2014 – 2017 Co-mentor: Edward Chang, MD, UC San Francisco Education MD 2010, Mount Sinai School of Medicine, New York, NY Medical Scientist Training Program (MSTP), 2002 – 2010 PhD 2008, Mount Sinai School of Medicine, New York, NY Department of Neuroscience BS 2002, Tufts University, Medford, MA Majors in Biology and Classical Studies Awards & 2019 – 2021 Brain and Behavior Research Foundation NARSAD Young Research Investigator Grant The Neural Basis of Expectation and Bias in Large-scale Support Brain Networks 2018 – 2021 Whitehall Foundation Research Grant Neural mechanisms of self- generated mnemonic strategies 2018 – 2022 Pew Scholars Program in Biomedical Sciences, The neural basis of expectation and bias in large-scale orbitofrontal networks 2018 Schneider-Lesser Foundation Junior Faculty Fellowship 2015 – 2020 K08 Mentored Clinical Scientist Research Development Award, NIH/NIDA, Multi-Scale Orbitofrontal -
Covert Shift of Attention Modulates the Value Encoding in the Orbitofrontal Cortex Yang Xie1,2, Chechang Nie1,2, Tianming Yang1*
RESEARCH ARTICLE Covert shift of attention modulates the value encoding in the orbitofrontal cortex Yang Xie1,2, Chechang Nie1,2, Tianming Yang1* 1Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; 2University of Chinese Academy of Sciences, Beijing, China Abstract During value-based decision making, we often evaluate the value of each option sequentially by shifting our attention, even when the options are presented simultaneously. The orbitofrontal cortex (OFC) has been suggested to encode value during value-based decision making. Yet it is not known how its activity is modulated by attention shifts. We investigated this question by employing a passive viewing task that allowed us to disentangle effects of attention, value, choice and eye movement. We found that the attention modulated OFC activity through a winner-take-all mechanism. When we attracted the monkeys’ attention covertly, the OFC neuronal activity reflected the reward value of the newly attended cue. The shift of attention could be explained by a normalization model. Our results strongly argue for the hypothesis that the OFC neuronal activity represents the value of the attended item. They provide important insights toward understanding the OFC’s role in value-based decision making. DOI: https://doi.org/10.7554/eLife.31507.001 Introduction Imagine you are standing before a fruit stand and trying to buy some apples. Facing a box of apples, *For correspondence: you usually will pick up one apple at a time, evaluate it, decide whether you will have it or leave it, [email protected] and then move on to the next apple until you have chosen enough. -
UC Berkeley UC Berkeley Electronic Theses and Dissertations
UC Berkeley UC Berkeley Electronic Theses and Dissertations Title Prefrontal Mechanisms Underlying Sequential Tasks Permalink https://escholarship.org/uc/item/7510v08r Author Chiang, Feng-Kuei Publication Date 2017 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California Prefrontal Mechanisms Underlying Sequential Tasks By Feng-Kuei Chiang A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Psychology in the Graduate Division of the University of California, Berkeley Committee in charge: Professor Joni Wallis, Chair Professor Richard B. Ivry Professor Ming Hsu Summer 2017 Prefrontal Mechanisms Underlying Sequential Tasks Copyright c 2017 by Feng-Kuei Chiang Abstract Prefrontal Mechanisms Underlying Sequential Tasks by Feng-Kuei Chiang Doctor of Philosophy in Psychology University of California, Berkeley Professor Joni Wallis, Chair For decades, mechanisms of cognitive behaviors have been studied in a simple form of stimulus- and action-outcome associations. Those seminal studies serve as funda- mental frameworks and enable us to explore how neural activities in brain represent the increasingly complex and temporarily-extended associations in sequential tasks. The prefrontal cortex (PFC) has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal representation. In particular, PFC \top-down" processes serve as an internal signal to guide high-level cognitive functions, such as working memory (WM), abstract rules, or goal-directed decision-making. Several models have described how task information, in- cluding supra- and super-ordinate information, is organized in prefrontal cortex, but it remains unclear precisely how this cognitive information maps onto neurophysiological functions. -
Talk & Poster Abstracts
TALK &POSTER ABSTRACTS WWW.RLDM.ORG TABLE OF CONTENTS PREFACE 3 INVITED SPEAKER ABSTRACTS 4 CONTRIBUTED SPEAKER ABSTRACTS 9 MONDAY POSTER ABSTRACTS 14 TUESDAY POSTER ABSTRACTS 74 PROGRAM COMMITTEE 132 2 Preface Welcome to Reinforcement Learning and Decision Making 2019! Over the last few decades, reinforcement learning and decision making have been the focus of an incredible wealth of research in a wide variety of fields including psychology, animal and human neuroscience, artifi- cial intelligence, machine learning, robotics, operations research, neuroeconomics and ethology. All these fields, despite their differences, share a common ambition—understanding the information processing that leads to the effective achievement of goals. Key to many developments has been multidisciplinary sharing of ideas and findings. However, the com- monalities are frequently obscured by differences in language and methodology. To remedy this issue, the RLDM meetings were started in 2013 with the explicit goal of fostering multidisciplinary discussion across the fields. RLDM 2019 is the fourth such meeting. Our primary form of discourse is intended to be cross-disciplinary conversations, with teaching and learn- ing being central objectives, along with the dissemination of novel theoretical and experimental results. To accommodate the variegated traditions of the contributing communities, we do not have an official pro- ceedings. Nevertheless, some authors have agreed to make their extended abstracts available, which can be downloaded from the RLDM website. We would like to conclude by thanking all past organizers, speakers, authors and members of the program committee. Your hard work is the bedrock of a successful conference. We hope you enjoy RLDM2019. Satinder Singh, General chair Catherine Hartley and Michael L. -
About Cosyne
Program Summary All times are EST (Eastern Standard Time, GMT-5) Tuesday, 23 February 11:00a Cosyne Tutorial: Recurrent Neural Networks for Neuroscience 03:00p Paths for leadership in promoting the careers of scientists Wednesday, 24 February 08:00a Poster Session 1a 10:00a Session 1: 3 accepted talks 11:40a Session 2: 4 accepted talks 01:00p Simons Foundation Bridge to Independence Awards: Facilitating the transition from postdoc to junior faculty 02:00p Session 3: 3 accepted talks 03:00p Poster Session 1b 05:00p Mini-symposium on the history of race and racism in science 07:00p Poster Session 1c Thursday, 25 February 08:00a Poster Session 2a 10:00a Session 4: 3 accepted talks 11:40a Session 5: 4 accepted talks 02:00p Session 6: 3 accepted talks 03:00p Poster Session 2b 05:00p Expanding horizons: Diverse perspectives in computational neuroscience 07:00p Poster Session 2c Friday, 26 February 08:00a Poster Session 3a 10:00a Session 7: 3 accepted talks 11:40a Session 8: 4 accepted talks 02:00p Session 9: 3 accepted talks 03:00p Poster Session 3b 07:00p Poster Session 3c COSYNE 2021 i ii COSYNE 2021 About Cosyne About Cosyne The annual Cosyne meeting provides an inclusive forum for the exchange of experimental and theoretical/computational approaches to problems in systems neuroscience. To encourage interdisciplinary interactions, the main meeting is arranged in a single track. A set of invited talks are selected by the Executive Committee and Organizing Commit- tee, and additional talks and posters are selected by the Program Committee, based on submitted abstracts.