Instability Clinical Start End Ref Mut Gene Tumour Metastatic Chr Mutation type cDNA and amino acid change phenotype stage position position allele allele

APC 1 CIN IV Yes, at diagnosis 5 112175255 112175255 G T stopgain_SNV APC:NM_001127511:exon14:c.G3910T:p.E1304X

BTK 1 CIN IV Yes, at diagnosis X 100630256 100630256 A G nonsynonymous_SNV BTK:NM_000061:exon2:c.T17C:p.L6P

DNAH3 1 CIN IV Yes, at diagnosis 16 20975432 20975432 G A synonymous_SNV DNAH3:NM_017539:exon53:c.C9774T:p.T3258T

EPHA5 1 CIN IV Yes, at diagnosis 4 66218787 66218787 C T synonymous_SNV EPHA5:NM_182472:exon12:c.G2205A:p.E735E

HDAC9 1 CIN IV Yes, at diagnosis 7 18767228 18767228 G A nonsynonymous_SNV HDAC9:NM_058176:exon12:c.G1748A:p.R583H

KRAS 1 CIN IV Yes, at diagnosis 12 25398285 25398285 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G34A:p.G12S

MST1R 1 CIN IV Yes, at diagnosis 3 49940931 49940931 G T nonsynonymous_SNV MST1R:NM_001244937:exon1:c.C112A:p.R38S

PDGFRA 1 CIN IV Yes, at diagnosis 4 55152121 55152121 G T synonymous_SNV PDGFRA:NM_006206:exon18:c.G2553T:p.S851S

PIK3C2G 1 CIN IV Yes, at diagnosis 12 18641534 18641534 G T nonsynonymous_SNV PIK3C2G:NM_004570:exon18:c.G2533T:p.V845F

SMARCA5 1 CIN IV Yes, at diagnosis 4 144442586 144442586 C A nonsynonymous_SNV SMARCA5:NM_003601:exon3:c.C257A:p.T86N

AKT1 3 CIN IV Yes, at diagnosis 14 105239238 105239238 C A synonymous_SNV AKT1:NM_001014431:exon11:c.G1149T:p.L383L

APC 3 CIN IV Yes, at diagnosis 5 112173531 112173531 C A stopgain_SNV APC:NM_001127511:exon14:c.C2186A:p.S729X

CACNA1I 3 CIN IV Yes, at diagnosis 22 40081888 40081888 G T synonymous_SNV CACNA1I:NM_001003406:exon36:c.G6045T:p.A2015A

ITPR1 3 CIN IV Yes, at diagnosis 3 4878604 4878604 G A synonymous_SNV ITPR1:NM_002222:exon57:c.G7986A:p.S2662S

KRAS 3 CIN IV Yes, at diagnosis 12 25398284 25398284 C A nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35T:p.G12V

P2RX1 3 CIN IV Yes, at diagnosis 17 3819420 3819420 G A stopgain_SNV P2RX1:NM_002558:exon1:c.C100T:p.R34X

PIK3CA 3 CIN IV Yes, at diagnosis 3 178936091 178936091 G A nonsynonymous_SNV p.E545K

RET 3 CIN IV Yes, at diagnosis 10 43619222 43619222 C T nonsynonymous_SNV RET:NM_020630:exon17:c.C2905T:p.R969W

RYR1 3 CIN IV Yes, at diagnosis 19 38954143 38954143 C T synonymous_SNV RYR1:NM_000540:exon21:c.C2658T:p.I886I

SMAD4 3 CIN IV Yes, at diagnosis 18 48604748 48604748 T A nonsynonymous_SNV SMAD4:NM_005359:exon12:c.T1570A:p.W524R

TP53 3 CIN IV Yes, at diagnosis 17 7578479 7578479 - G frameshift_insertion TP53:NM_001126115:exon1:c.55dupC:p.P19fs

TSC1 3 CIN IV Yes, at diagnosis 9 135781440 135781440 G A stopgain_SNV TSC1:NM_001162427:exon14:c.C1372T:p.R458X

ULK1 3 CIN IV Yes, at diagnosis 12 132402020 132402020 T C synonymous_SNV ULK1:NM_003565:exon22:c.T2247C:p.P749P

APC 5 CIN IV Yes, at diagnosis 5 112175681 112175681 G T stopgain_SNV APC:NM_001127511:exon14:c.G4336T:p.E1446X

ATM 5 CIN IV Yes, at diagnosis 11 108117798 108117798 C T nonsynonymous_SNV ATM:NM_000051:exon8:c.C1009T:p.R337C

CACNA1C 5 CIN IV Yes, at diagnosis 12 2795367 2795367 C T stopgain_SNV CACNA1C:NM_001129837:exon44:c.C5740T:p.R1914X

DDR2 5 CIN IV Yes, at diagnosis 1 162688905 162688905 T A nonsynonymous_SNV DDR2:NM_006182:exon3:c.T52A:p.L18M

EPHA6 5 CIN IV Yes, at diagnosis 3 97329638 97329638 C T synonymous_SNV EPHA6:NM_173655:exon11:c.C690T:p.G230G

IRS2 5 CIN IV Yes, at diagnosis 13 110435157 110435157 T G nonsynonymous_SNV IRS2:NM_003749:exon1:c.A3244C:p.T1082P

KRAS 5 CIN IV Yes, at diagnosis 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

NAV3 5 CIN IV Yes, at diagnosis 12 78513203 78513203 C G nonsynonymous_SNV NAV3:NM_014903:exon15:c.C3227G:p.S1076C

NTRK3 5 CIN IV Yes, at diagnosis 15 88423598 88423598 T G nonsynonymous_SNV NTRK3:NM_001243101:exon17:c.A2171C:p.K724T

PLCG2 5 CIN IV Yes, at diagnosis 16 81944235 81944236 AG - frameshift_deletion PLCG2:NM_002661:exon18:c.1844_1845del:p.615_615del PTPRQ 5 CIN IV Yes, at diagnosis 12 80890208 80890208 T G nonsynonymous_SNV PTPRQ:NM_001145026:exon11:c.T1654G:p.L552V

RYR3 5 CIN IV Yes, at diagnosis 15 33936684 33936684 G A synonymous_SNV RYR3:NM_001036:exon28:c.G3729A:p.T1243T

SMAD1 5 CIN IV Yes, at diagnosis 4 146479082 146479082 C G nonsynonymous_SNV SMAD1:NM_001003688:exon7:c.C1394G:p.S465C

TRIM33 5 CIN IV Yes, at diagnosis 1 114970460 114970460 G C synonymous_SNV TRIM33:NM_015906:exon7:c.C1212G:p.G404G

ACVR1B 7 MSI-H III No 12 52379124 52379124 G - frameshift_deletion ACVR1B:NM_004302:exon6:c.1128delG:p.G376fs

ACVR1B 7 MSI-H III No 12 52370204 52370204 T A nonsynonymous_SNV ACVR1B:NM_004302:exon3:c.T425A:p.I142N

ACVR1B 7 MSI-H III No 12 52387796 52387796 C T stopgain_SNV ACVR1B:NM_004302:exon9:c.C1420T:p.R474X

ACVR1B 7 MSI-H III No 12 52380656 52380656 C T synonymous_SNV ACVR1B:NM_004302:exon7:c.C1191T:p.S397S

ACVR2A 7 MSI-H III No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

AKAP11 7 MSI-H III No 13 42876175 42876175 C A nonsynonymous_SNV AKAP11:NM_016248:exon8:c.C3293A:p.P1098H

AKAP12 7 MSI-H III No 6 151671336 151671336 A - frameshift_deletion AKAP12:NM_144497:exon2:c.1516delA:p.R506fs

AKAP9 7 MSI-H III No 7 91671392 91671393 AG - frameshift_deletion AKAP9:NM_005751:exon19:c.4950_4951del:p.1650_1651del

APC 7 MSI-H III No 5 112175957 112175957 - A frameshift_insertion APC:NM_001127511:exon14:c.4612dupA:p.T1538fs

APC 7 MSI-H III No 5 112178208 112178208 A G nonsynonymous_SNV APC:NM_001127511:exon14:c.A6863G:p.D2288G

APC 7 MSI-H III No 5 112177249 112177249 T G synonymous_SNV APC:NM_001127511:exon14:c.T5904G:p.P1968P

ARID1A 7 MSI-H III No 1 27106861 27106861 C T stopgain_SNV ARID1A:NM_006015:exon20:c.C6472T:p.R2158X

ARID1B 7 MSI-H III No 6 157527976 157527976 A T nonsynonymous_SNV ARID1B:NM_017519:exon19:c.A5662T:p.S1888C

ARID2 7 MSI-H III No 12 46244140 46244140 A G nonsynonymous_SNV ARID2:NM_152641:exon15:c.A2234G:p.Q745R

ATP2B2 7 MSI-H III No 3 10491194 10491194 T - frameshift_deletion ATP2B2:NM_001001331:exon2:c.34delA:p.K12fs

ATP2B2 7 MSI-H III No 3 10392234 10392234 G A nonsynonymous_SNV ATP2B2:NM_001683:exon12:c.C2029T:p.R677W

ATP2B3 7 MSI-H III No X 152835128 152835128 T A nonsynonymous_SNV ATP2B3:NM_021949:exon20:c.T3410A:p.V1137D

ATP2B4 7 MSI-H III No 1 203696598 203696598 A G nonsynonymous_SNV ATP2B4:NM_001001396:exon20:c.A3208G:p.T1070A

ATRX 7 MSI-H III No X 76829720 76829720 A C nonsynonymous_SNV ATRX:NM_138270:exon27:c.T6207G:p.N2069K

AXIN2 7 MSI-H III No 17 63533833 63533833 C T nonsynonymous_SNV AXIN2:NM_004655:exon6:c.G1321A:p.D441N

BAZ2B 7 MSI-H III No 2 160261360 160261360 C A nonsynonymous_SNV BAZ2B:NM_013450:exon16:c.G2832T:p.Q944H

BIRC5 7 MSI-H III No 17 76210419 76210419 C T nonsynonymous_SNV BIRC5:NM_001012270:exon1:c.C22T:p.P8S

BMPR2 7 MSI-H III No 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BRAF 7 MSI-H III No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1B 7 MSI-H III No 9 140953048 140953048 G A nonsynonymous_SNV CACNA1B:NM_000718:exon29:c.G4336A:p.A1446T

CACNA1B 7 MSI-H III No 9 140777198 140777198 C T synonymous_SNV CACNA1B:NM_000718:exon3:c.C393T:p.D131D

CACNA1E 7 MSI-H III No 1 181767891 181767891 G A nonsynonymous_SNV CACNA1E:NM_001205294:exon46:c.G6677A:p.R2226H

CACNA1G 7 MSI-H III No 17 48653088 48653088 A G nonsynonymous_SNV CACNA1G:NM_001256324:exon8:c.A1325G:p.Y442C

CACNA1I 7 MSI-H III No 22 40075301 40075301 G A nonsynonymous_SNV CACNA1I:NM_001003406:exon31:c.G5140A:p.E1714K

CACNA1S 7 MSI-H III No 1 201012534 201012534 A G synonymous_SNV CACNA1S:NM_000069:exon40:c.T4923C:p.P1641P CACNA1S 7 MSI-H III No 1 201016720 201016720 G T synonymous_SNV CACNA1S:NM_000069:exon37:c.C4476A:p.A1492A

CACNA2D1 7 MSI-H III No 7 81978958 81978958 A T nonsynonymous_SNV CACNA2D1:NM_000722:exon2:c.T103A:p.S35T

CACNA2D4 7 MSI-H III No 12 1965373 1965373 T G synonymous_SNV CACNA2D4:NM_172364:exon21:c.A2031C:p.P677P

CACNG4 7 MSI-H III No 17 64961098 64961098 T C nonsynonymous_SNV CACNG4:NM_014405:exon1:c.T71C:p.M24T

CALR 7 MSI-H III No 19 13054398 13054398 G T nonsynonymous_SNV CALR:NM_004343:exon8:c.G1008T:p.E336D

CAMK2B 7 MSI-H III No 7 44323828 44323828 G A splicing mutation CAMK2B(NM_172083:exon3:c.66-4C>T

CANX 7 MSI-H III No 5 179149927 179149927 T - frameshift_deletion CANX:NM_001024649:exon11:c.1305delT:p.F435fs

CHD1 7 MSI-H III No 5 98235375 98235375 T C synonymous_SNV CHD1:NM_001270:exon7:c.A894G:p.E298E

CHD6 7 MSI-H III No 20 40085900 40085900 T C splicing mutation CHD6(NM_032221:exon19:c.2829+4A>G)

CHD8 7 MSI-H III No 14 21863135 21863135 G A stopgain_SNV CHD8:NM_001170629:exon29:c.C5326T:p.R1776X

CHD9 7 MSI-H III No 16 53340162 53340162 C T synonymous_SNV CHD9:NM_025134:exon32:c.C6633T:p.H2211H

CTNNB1 7 MSI-H III No 3 41266446 41266446 T C synonymous_SNV CTNNB1:NM_001098209:exon4:c.T243C:p.D81D

CTNNB1 7 MSI-H III No 3 41275040 41275040 T G synonymous_SNV CTNNB1:NM_001098209:exon9:c.T1206G:p.L402L

CTNND2 7 MSI-H III No 5 11384954 11384954 G - frameshift_deletion CTNND2:NM_001332:exon7:c.1000delC:p.P334fs

CUL1 7 MSI-H III No 7 148484154 148484154 T C nonsynonymous_SNV CUL1:NM_003592:exon13:c.T1421C:p.L474P

DAXX 7 MSI-H III No 6 33288687 33288687 C T nonsynonymous_SNV DAXX:NM_001254717:exon2:c.G640A:p.V214M

DNMT1 7 MSI-H III No 19 10270521 10270521 G A synonymous_SNV DNMT1:NM_001379:exon15:c.C1119T:p.D373D

DNMT3A 7 MSI-H III No 2 25467105 25467105 A G synonymous_SNV DNMT3A:NM_153759:exon11:c.T1203C:p.G401G

DOCK3 7 MSI-H III No 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

DOCK3 7 MSI-H III No 3 51399383 51399383 C T synonymous_SNV DOCK3:NM_004947:exon48:c.C5100T:p.D1700D

DPF1 7 MSI-H III No 19 38703024 38703024 C T nonsynonymous_SNV DPF1:NM_004647:exon10:c.G968A:p.S323N

DPF2 7 MSI-H III No 11 65116380 65116380 G A synonymous_SNV DPF2:NM_006268:exon10:c.G1077A:p.P359P

DVL3 7 MSI-H III No 3 183888275 183888275 C T nonsynonymous_SNV DVL3:NM_004423:exon15:c.C1883T:p.A628V

EP300 7 MSI-H III No 22 41554447 41554447 A G nonsynonymous_SNV EP300:NM_001429:exon19:c.A3533G:p.Y1178C

EP400 7 MSI-H III No 12 132547094 132547096 CAG - nonframeshift_deletion EP400:NM_015409:exon47:c.8182_8184del:p.2728_2728del

EPHA1 7 MSI-H III No 7 143088801 143088801 G A nonsynonymous_SNV EPHA1:NM_005232:exon17:c.C2764T:p.L922F

EPHA10 7 MSI-H III No 1 38197151 38197151 G A nonsynonymous_SNV EPHA10:NM_001099439:exon7:c.C1595T:p.A532V

EPHA2 7 MSI-H III No 1 16458362 16458362 C T nonsynonymous_SNV EPHA2:NM_004431:exon14:c.G2329A:p.G777S

EPHA3 7 MSI-H III No 3 89391029 89391029 A - frameshift_deletion EPHA3:NM_005233:exon5:c.1095delA:p.K365fs

EPHA8 7 MSI-H III No 1 22923870 22923870 G T nonsynonymous_SNV EPHA8:NM_020526:exon10:c.G1831T:p.A611S

EPHB1 7 MSI-H III No 3 134873043 134873043 C A nonsynonymous_SNV EPHB1:NM_004441:exon6:c.C1347A:p.S449R

EPHB3 7 MSI-H III No 3 184294935 184294935 C T nonsynonymous_SNV EPHB3:NM_004443:exon5:c.C1318T:p.R440C

EPHB3 7 MSI-H III No 3 184290756 184290756 C T synonymous_SNV EPHB3:NM_004443:exon3:c.C648T:p.T216T

EXOC4 7 MSI-H III No 7 133622720 133622720 C T nonsynonymous_SNV EXOC4:NM_021807:exon14:c.C2104T:p.R702C FGFR4 7 MSI-H III No 5 176523146 176523146 T C nonsynonymous_SNV FGFR4:NM_022963:exon12:c.T1790C:p.V597A

FHOD3 7 MSI-H III No 18 34205521 34205521 C - frameshift_deletion FHOD3:NM_025135:exon10:c.1005delC:p.P335fs

FNDC1 7 MSI-H III No 6 159660695 159660695 A - frameshift_deletion FNDC1:NM_032532:exon14:c.4327delA:p.T1443fs

FNDC1 7 MSI-H III No 6 159653240 159653240 C A nonsynonymous_SNV FNDC1:NM_032532:exon11:c.C1696A:p.L566M

GNA11 7 MSI-H III No 19 3110245 3110245 G A nonsynonymous_SNV GNA11:NM_002067:exon2:c.G235A:p.V79I

GNA14 7 MSI-H III No 9 80262705 80262705 G A nonsynonymous_SNV GNA14:NM_004297:exon1:c.C5T:p.A2V

GRIN1 7 MSI-H III No 9 140042613 140042613 A - frameshift_deletion GRIN1:NM_001185090:exon4:c.580delA:p.R194fs

GRIN2A 7 MSI-H III No 16 9857680 9857680 G A nonsynonymous_SNV GRIN2A:NM_001134407:exon13:c.C3721T:p.R1241W

GRIN2D 7 MSI-H III No 19 48945083 48945083 C T synonymous_SNV GRIN2D:NM_000836:exon11:c.C2310T:p.D770D

HDAC4 7 MSI-H III No 2 240098212 240098212 T C synonymous_SNV HDAC4:NM_006037:exon5:c.A387G:p.E129E

HDAC6 7 MSI-H III No X 48664834 48664834 T C nonsynonymous_SNV HDAC6:NM_006044:exon7:c.T497C:p.V166A

HDAC7 7 MSI-H III No 12 48190822 48190822 C T synonymous_SNV HDAC7:NM_001098416:exon7:c.G681A:p.R227R

HIF1A 7 MSI-H III No 14 62207293 62207293 T C nonsynonymous_SNV HIF1A:NM_001243084:exon11:c.T1679C:p.V560A

IKBKE 7 MSI-H III No 1 206664161 206664162 AC - frameshift_deletion IKBKE:NM_001193321:exon16:c.1448_1449del:p.483_483del

IKBKE 7 MSI-H III No 1 206664164 206664164 A - frameshift_deletion IKBKE:NM_001193321:exon16:c.1451delA:p.N484fs

INSR 7 MSI-H III No 19 7184651 7184651 - GA splicing mutation INSR(NM_000208:exon4:c.653-3->TC

INSR 7 MSI-H III No 19 7174634 7174634 G T synonymous_SNV INSR:NM_000208:exon4:c.C1083A:p.T361T

IRS1 7 MSI-H III No 2 227661671 227661671 C - frameshift_deletion IRS1:NM_005544:exon1:c.1784delG:p.R595fs

IRS1 7 MSI-H III No 2 227662007 227662007 T C nonsynonymous_SNV IRS1:NM_005544:exon1:c.A1448G:p.Y483C

IRS1 7 MSI-H III No 2 227661620 227661620 T C nonsynonymous_SNV IRS1:NM_005544:exon1:c.A1835G:p.Y612C

ITK 7 MSI-H III No 5 156671450 156671450 G A nonsynonymous_SNV ITK:NM_005546:exon13:c.G1411A:p.A471T

ITPR1 7 MSI-H III No 3 4716003 4716003 A C nonsynonymous_SNV ITPR1:NM_001168272:exon21:c.A2529C:p.K843N

ITPR1 7 MSI-H III No 3 4706937 4706937 A G nonsynonymous_SNV ITPR1:NM_001168272:exon16:c.A1625G:p.Y542C

ITPR1 7 MSI-H III No 3 4735191 4735191 G A synonymous_SNV ITPR1:NM_001168272:exon32:c.G4002A:p.E1334E

ITPR2 7 MSI-H III No 12 26647135 26647135 C T nonsynonymous_SNV ITPR2:NM_002223:exon39:c.G5321A:p.G1774D

ITPR3 7 MSI-H III No 6 33646497 33646497 C A nonsynonymous_SNV ITPR3:NM_002224:exon30:c.C3853A:p.H1285N

ITPR3 7 MSI-H III No 6 33635599 33635599 C T stopgain_SNV ITPR3:NM_002224:exon16:c.C1744T:p.Q582X

ITPR3 7 MSI-H III No 6 33639067 33639067 C A synonymous_SNV ITPR3:NM_002224:exon21:c.C2712A:p.A904A

JAK1 7 MSI-H III No 1 65332872 65332872 C A stopgain_SNV JAK1:NM_002227:exon7:c.G667T:p.E223X

JAK3 7 MSI-H III No 19 17955148 17955148 G A nonsynonymous_SNV JAK3:NM_000215:exon2:c.C79T:p.H27Y

JARID2 7 MSI-H III No 6 15496786 15496786 C T synonymous_SNV JARID2:NM_001267040:exon7:c.C814T:p.L272L

JMJD1C 7 MSI-H III No 10 65024436 65024436 T C nonsynonymous_SNV JMJD1C:NM_032776:exon3:c.A422G:p.E141G

JMJD7-PLA2G4B,PLA2G4B 7 MSI-H III No 15 42139630 42139630 C T synonymous_SNV PLA2G4B:NM_001114633:exon19:c.C2043T:p.C681C

JUN 7 MSI-H III No 1 59248124 59248126 GCT - nonframeshift_deletion JUN:NM_002228:exon1:c.617_619del:p.206_207del KAT6B 7 MSI-H III No 10 76735981 76735981 A G nonsynonymous_SNV KAT6B:NM_012330:exon8:c.A1886G:p.H629R

KAT8 7 MSI-H III No 16 31142266 31142266 A G nonsynonymous_SNV KAT8:NM_182958:exon10:c.A1357G:p.S453G

KDM3A 7 MSI-H III No 2 86707336 86707336 A G nonsynonymous_SNV KDM3A:NM_001146688:exon16:c.A2363G:p.Q788R

KDM4B 7 MSI-H III No 19 5151447 5151447 C T synonymous_SNV KDM4B:NM_015015:exon23:c.C3216T:p.S1072S

KDM6B 7 MSI-H III No 17 7751886 7751889 CACC - frameshift_deletion KDM6B:NM_001080424:exon11:c.2280_2283del:p.760_761del

KIAA0825 7 MSI-H III No 5 93731909 93731909 T C nonsynonymous_SNV KIAA0825:NM_001145678:exon17:c.A3193G:p.I1065V

KRAS 7 MSI-H III No 12 25378546 25378546 A G splicing mutation KRAS(NM_033360:exon5:c.450+2T>C

LEF1 7 MSI-H III No 4 108991824 108991824 T C nonsynonymous_SNV LEF1:NM_001130713:exon8:c.A1027G:p.N343D

LEPREL1 7 MSI-H III No 3 189838117 189838117 T C nonsynonymous_SNV LEPREL1:NM_018192:exon1:c.A404G:p.H135R

MAPK12 7 MSI-H III No 22 50695623 50695623 C T splicing mutation MAPK12(NM_002969:exon5:c.315-1G>A)

MAPK4 7 MSI-H III No 18 48255852 48255852 G A synonymous_SNV MAPK4:NM_002747:exon6:c.G1392A:p.K464K

MAPK8IP3 7 MSI-H III No 16 1816238 1816238 G A nonsynonymous_SNV MAPK8IP3:NM_001040439:exon21:c.G2626A:p.A876T

MAPKBP1 7 MSI-H III No 15 42114832 42114832 A T nonsynonymous_SNV MAPKBP1:NM_001265611:exon27:c.A3271T:p.I1091F

MERTK 7 MSI-H III No 2 112686919 112686919 C T nonsynonymous_SNV MERTK:NM_006343:exon2:c.C284T:p.A95V

MLH1 7 MSI-H III No 3 37050354 37050354 A - frameshift_deletion MLH1:NM_000249:exon6:c.503delA:p.N168fs

MLH3 7 MSI-H III No 14 75508402 75508402 A G synonymous_SNV MLH3:NM_001040108:exon4:c.T3381C:p.D1127D

MLL2 7 MSI-H III No 12 49437779 49437779 T G nonsynonymous_SNV MLL2:NM_003482:exon22:c.A5191C:p.I1731L

MLL2 7 MSI-H III No 12 49422911 49422911 G A synonymous_SNV MLL2:NM_003482:exon44:c.C14184T:p.G4728G

MLL2 7 MSI-H III No 12 49424976 49424976 A G synonymous_SNV MLL2:NM_003482:exon39:c.T13512C:p.G4504G

MLL4 7 MSI-H III No 19 36223007 36223007 G - frameshift_deletion MLL4:NM_014727:exon27:c.5636delG:p.G1879fs

MLL4 7 MSI-H III No 19 36213330 36213330 C A synonymous_SNV MLL4:NM_014727:exon4:c.C2527A:p.R843R

MLL5 7 MSI-H III No 7 104702685 104702685 G A nonsynonymous_SNV MLL5:NM_018682:exon3:c.G146A:p.S49N

MSH2 7 MSI-H III No 2 47635649 47635649 T C synonymous_SNV MSH2:NM_000251:exon2:c.T321C:p.A107A

MTOR 7 MSI-H III No 1 11181309 11181309 G A synonymous_SNV MTOR:NM_004958:exon49:c.C6927T:p.S2309S

NAV3 7 MSI-H III No 12 78444677 78444677 G A nonsynonymous_SNV NAV3:NM_014903:exon11:c.G2266A:p.A756T

NEDD4L 7 MSI-H III No 18 56010323 56010323 G T nonsynonymous_SNV NEDD4L:NM_001144970:exon14:c.G1140T:p.K380N

NRAS 7 MSI-H III No 1 115252190 115252190 C A nonsynonymous_SNV NRAS:NM_002524:exon4:c.G450T:p.Q150H

NTRK1 7 MSI-H III No 1 156841468 156841468 C T synonymous_SNV NTRK1:NM_001012331:exon7:c.C771T:p.D257D

PAK4 7 MSI-H III No 19 39660292 39660292 G A synonymous_SNV PAK4:NM_001014832:exon2:c.G99A:p.T33T

PBRM1 7 MSI-H III No 3 52598163 52598163 G A nonsynonymous_SNV PBRM1:NM_018313:exon24:c.C3703T:p.R1235C

PDGFRA 7 MSI-H III No 4 55156567 55156567 G A nonsynonymous_SNV PDGFRA:NM_006206:exon22:c.G2968A:p.G990S

PDK2 7 MSI-H III No 17 48174902 48174902 A G synonymous_SNV PDK2:NM_001199899:exon2:c.A42G:p.T14T

PER1 7 MSI-H III No 17 8045158 8045158 G A nonsynonymous_SNV PER1:NM_002616:exon22:c.C3565T:p.R1189W

PIK3CG 7 MSI-H III No 7 106509749 106509749 A C nonsynonymous_SNV PIK3CG:NM_002649:exon2:c.A1743C:p.E581D PIK3CG 7 MSI-H III No 7 106508853 106508853 G T nonsynonymous_SNV PIK3CG:NM_002649:exon2:c.G847T:p.G283C

PIK3R5 7 MSI-H III No 17 8790863 8790863 T C nonsynonymous_SNV PIK3R5:NM_001251852:exon10:c.A596G:p.D199G

PLCB4 7 MSI-H III No 20 9404497 9404497 T C nonsynonymous_SNV PLCB4:NM_000933:exon24:c.T2386C:p.Y796H

PLCD1 7 MSI-H III No 3 38058126 38058126 C T nonsynonymous_SNV PLCD1:NM_001130964:exon3:c.G347A:p.R116H

PLCZ1 7 MSI-H III No 12 18858213 18858213 G A nonsynonymous_SNV PLCZ1:NM_033123:exon7:c.C751T:p.H251Y

PRKD1 7 MSI-H III No 14 30194741 30194741 C T splicing mutation PRKD1(NM_002742:exon3:c.403+1G>A)

PRKDC 7 MSI-H III No 8 48775093 48775093 G A unknown UNKNOWN

PRKDC 7 MSI-H III No 8 48848446 48848446 A G unknown UNKNOWN

PRKDC 7 MSI-H III No 8 48701584 48701584 T C unknown UNKNOWN

PRKDC 7 MSI-H III No 8 48866919 48866919 T - unknown UNKNOWN

PTPN13 7 MSI-H III No 4 87671900 87671901 CT - frameshift_deletion PTPN13:NM_006264:exon18:c.2928_2929del:p.976_977del

PTPN14 7 MSI-H III No 1 214549714 214549714 T - frameshift_deletion PTPN14:NM_005401:exon15:c.2755delA:p.K919fs

PTPN21 7 MSI-H III No 14 88940120 88940120 T - frameshift_deletion PTPN21:NM_007039:exon14:c.2538delA:p.A846fs

PTPN23 7 MSI-H III No 3 47447405 47447405 G T nonsynonymous_SNV PTPN23:NM_015466:exon6:c.G415T:p.G139C

PTPRB 7 MSI-H III No 12 70954449 70954449 A G splicing mutation PTPRB(NM_001206972:exon15:c.3508+2T>C

PTPRB 7 MSI-H III No 12 70918315 70918315 T C synonymous_SNV PTPRB:NM_001206971:exon30:c.A5637G:p.L1879L

PTPRC 7 MSI-H III No 1 198666041 198666041 T C splicing mutation PTPRC(NM_002838:exon4:c.298+3T>C)

PTPRE 7 MSI-H III No 10 129866413 129866413 C - frameshift_deletion PTPRE:NM_130435:exon9:c.696delC:p.P232fs

PTPRG 7 MSI-H III No 3 62189111 62189111 G A nonsynonymous_SNV PTPRG:NM_002841:exon12:c.G1642A:p.A548T

PTPRJ 7 MSI-H III No 11 48152053 48152053 C A nonsynonymous_SNV PTPRJ:NM_001098503:exon8:c.C1400A:p.T467K

PTPRM 7 MSI-H III No 18 8143777 8143777 G T nonsynonymous_SNV PTPRM:NM_001105244:exon14:c.G2300T:p.R767M

PTPRN 7 MSI-H III No 2 220162053 220162053 C T nonsynonymous_SNV PTPRN:NM_001199763:exon13:c.G1903A:p.A635T

PTPRO 7 MSI-H III No 12 15669817 15669817 A G nonsynonymous_SNV PTPRO:NM_002848:exon9:c.A1706G:p.N569S

PTPRS 7 MSI-H III No 19 5286112 5286112 C T nonsynonymous_SNV PTPRS:NM_002850:exon2:c.G40A:p.G14S

PTPRS 7 MSI-H III No 19 5244182 5244182 G A stopgain_SNV PTPRS:NM_130853:exon8:c.C1261T:p.Q421X

PTPRT 7 MSI-H III No 20 41101097 41101097 T C nonsynonymous_SNV PTPRT:NM_007050:exon8:c.A1259G:p.Y420C

PTPRT 7 MSI-H III No 20 40864899 40864899 C A splicing mutation PTPRT(NM_133170:exon17:c.2370-1G>T

PTPRZ1 7 MSI-H III No 7 121651470 121651470 T C synonymous_SNV PTPRZ1:NM_002851:exon12:c.T2370C:p.S790S

RASGRP1 7 MSI-H III No 15 38803800 38803800 C T splicing mutation RASGRP1(NM_001128602:exon9:c.966+5G>A

ROR2 7 MSI-H III No 9 94519683 94519683 G A nonsynonymous_SNV ROR2:NM_004560:exon3:c.C334T:p.R112W

ROR2 7 MSI-H III No 9 94519661 94519661 C T nonsynonymous_SNV ROR2:NM_004560:exon3:c.G356A:p.R119Q

ROS1 7 MSI-H III No 6 117681113 117681113 C T nonsynonymous_SNV ROS1:NM_002944:exon23:c.G3507A:p.M1169I

RPTOR 7 MSI-H III No 17 78933964 78933964 C T synonymous_SNV RPTOR:NM_001163034:exon26:c.C3090T:p.G1030G

RRM1 7 MSI-H III No 11 4128765 4128765 T C synonymous_SNV RRM1:NM_001033:exon4:c.T387C:p.D129D RRM2 7 MSI-H III No 2 10269010 10269010 A G synonymous_SNV RRM2:NM_001034:exon8:c.A834G:p.K278K

RYR1 7 MSI-H III No 19 38964052 38964052 C - frameshift_deletion RYR1:NM_000540:exon28:c.3801delC:p.P1267fs

RYR1 7 MSI-H III No 19 38934231 38934231 T C nonsynonymous_SNV RYR1:NM_000540:exon4:c.T304C:p.Y102H

RYR1 7 MSI-H III No 19 38946270 38946270 C T splicing mutation RYR1(NM_001042723:exon16:c.1673-3C>T

RYR2 7 MSI-H III No 1 237711849 237711849 C T nonsynonymous_SNV RYR2:NM_001035:exon26:c.C3025T:p.R1009W

RYR3 7 MSI-H III No 15 33952600 33952600 C T nonsynonymous_SNV RYR3:NM_001036:exon34:c.C4598T:p.A1533V

SETD1B 7 MSI-H III No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SETD1B 7 MSI-H III No 12 122265561 122265561 G T splicing mutation SETD1B(NM_015048:exon14:c.5340+5G>T)

SHC1 7 MSI-H III No 1 154938897 154938897 - C frameshift_insertion SHC1:NM_001130040:exon8:c.1080dupG:p.L360fs

SIK1 7 MSI-H III No 21 44840919 44840919 C T nonsynonymous_SNV SIK1:NM_173354:exon7:c.G719A:p.R240H

SLC24A1 7 MSI-H III No 15 65916826 65916826 T C synonymous_SNV SLC24A1:NM_004727:exon2:c.T408C:p.G136G

SLC25A4 7 MSI-H III No 4 186066252 186066252 C T nonsynonymous_SNV SLC25A4:NM_001151:exon2:c.C446T:p.A149V

SLC4A4 7 MSI-H III No 4 72222726 72222726 G A synonymous_SNV SLC4A4:NM_003759:exon3:c.G420A:p.E140E

SLC8A1 7 MSI-H III No 2 40342423 40342423 C A synonymous_SNV SLC8A1:NM_001112801:exon8:c.G2853T:p.L951L

SLC8A2 7 MSI-H III No 19 47969008 47969008 A - frameshift_deletion SLC8A2:NM_015063:exon2:c.653delT:p.V218fs

SMARCA2 7 MSI-H III No 9 2115857 2115857 G A synonymous_SNV SMARCA2:NM_003070:exon25:c.G3492A:p.G1164G

SMARCD2 7 MSI-H III No 17 61914320 61914320 G A nonsynonymous_SNV SMARCD2:NM_001098426:exon4:c.C529T:p.R177W

SMG1 7 MSI-H III No 16 18858922 18858922 A G nonsynonymous_SNV SMG1:NM_015092:exon38:c.T5849C:p.M1950T

SMG1 7 MSI-H III No 16 18851095 18851095 G T synonymous_SNV SMG1:NM_015092:exon42:c.C6870A:p.A2290A

SND1 7 MSI-H III No 7 127344930 127344930 T C nonsynonymous_SNV SND1:NM_014390:exon8:c.T878C:p.F293S

SOS1 7 MSI-H III No 2 39222526 39222526 T - frameshift_deletion SOS1:NM_005633:exon20:c.3084delA:p.P1028fs

SOS1 7 MSI-H III No 2 39294845 39294845 T G nonsynonymous_SNV SOS1:NM_005633:exon2:c.A137C:p.Q46P

STK11 7 MSI-H III No 19 1223090 1223090 G A nonsynonymous_SNV STK11:NM_000455:exon8:c.G1027A:p.D343N

SYK 7 MSI-H III No 9 93606304 93606304 C T nonsynonymous_SNV SYK:NM_001135052:exon2:c.C124T:p.R42C

SYK 7 MSI-H III No 9 93606348 93606348 C A synonymous_SNV SYK:NM_001135052:exon2:c.C168A:p.A56A

TCF7 7 MSI-H III No 5 133477937 133477937 C - frameshift_deletion TCF7:NM_213648:exon4:c.352delC:p.H118fs

TCF7L1 7 MSI-H III No 2 85360938 85360938 A G nonsynonymous_SNV TCF7L1:NM_031283:exon1:c.A131G:p.E44G

TCF7L2 7 MSI-H III No 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TEK 7 MSI-H III No 9 27185565 27185565 G T nonsynonymous_SNV TEK:NM_000459:exon9:c.G1265T:p.W422L

TGFBR1 7 MSI-H III No 9 101894850 101894850 T C nonsynonymous_SNV TGFBR1:NM_004612:exon3:c.T403C:p.C135R

TGFBRAP1 7 MSI-H III No 2 105924408 105924408 C - frameshift_deletion TGFBRAP1:NM_001142621:exon2:c.351delG:p.K117fs

TGFBRAP1 7 MSI-H III No 2 105889353 105889353 A G nonsynonymous_SNV TGFBRAP1:NM_001142621:exon10:c.T1931C:p.L644P

TGFBRAP1 7 MSI-H III No 2 105889462 105889462 A G nonsynonymous_SNV TGFBRAP1:NM_001142621:exon10:c.T1822C:p.Y608H

TRRAP 7 MSI-H III No 7 98478872 98478872 A G synonymous_SNV TRRAP:NM_001244580:exon2:c.A99G:p.T33T TXK 7 MSI-H III No 4 48073587 48073587 G T nonsynonymous_SNV TXK:NM_003328:exon14:c.C1462A:p.P488T

TYK2 7 MSI-H III No 19 10464771 10464771 C T nonsynonymous_SNV TYK2:NM_003331:exon20:c.G2855A:p.R952H

ULK1 7 MSI-H III No 12 132404685 132404685 C T splicing mutation ULK1(NM_003565:exon26:c.2961+4C>T)

UMPS 7 MSI-H III No 3 124456668 124456668 - A frameshift_insertion UMPS:NM_000373:exon3:c.564dupA:p.K188fs

ZFYVE9 7 MSI-H III No 1 52704835 52704835 G T nonsynonymous_SNV ZFYVE9:NM_004799:exon4:c.G1746T:p.K582N

ZFYVE9 7 MSI-H III No 1 52704706 52704706 T C synonymous_SNV ZFYVE9:NM_004799:exon4:c.T1617C:p.G539G

ZNF480 7 MSI-H III No 19 52825609 52825609 A T nonsynonymous_SNV ZNF480:NM_144684:exon5:c.A1106T:p.K369I

ZNF521 7 MSI-H III No 18 22806627 22806627 C A nonsynonymous_SNV ZNF521:NM_015461:exon4:c.G1255T:p.A419S

ALDH1L1 9 CIN III No 3 125876339 125876339 G A synonymous_SNV ALDH1L1:NM_001270364:exon4:c.C405T:p.H135H

APC 9 CIN III No 5 112128143 112128143 C T stopgain_SNV APC:NM_000038:exon7:c.C646T:p.R216X

ATP2B4 9 CIN III No 1 203708893 203708893 G T nonsynonymous_SNV ATP2B4:NM_001684:exon21:c.G3529T:p.A1177S

CHD1 9 CIN III No 5 98192165 98192167 AGG - nonframeshift_deletion CHD1:NM_001270:exon35:c.5050_5052del:p.1684_1684del

EPHA10 9 CIN III No 1 38218553 38218553 G T nonsynonymous_SNV EPHA10:NM_001099439:exon5:c.C1352A:p.P451H

JMJD1C 9 CIN III No 10 64967854 64967854 G T nonsynonymous_SNV JMJD1C:NM_004241:exon7:c.C2918A:p.S973Y

PTPRG 9 CIN III No 3 62177220 62177220 G A nonsynonymous_SNV PTPRG:NM_002841:exon9:c.G1111A:p.E371K

TP53 9 CIN III No 17 7578535 7578535 T G nonsynonymous_SNV TP53:NM_001126118:exon4:c.A278C:p.K93T

APC 11 CIN III Yes 5 112175255 112175255 G T stopgain_SNV APC:NM_001127511:exon14:c.G3910T:p.E1304X

BAZ2B 11 CIN III Yes 2 160284893 160284893 G A nonsynonymous_SNV BAZ2B:NM_013450:exon12:c.C2293T:p.R765C

CACNA1H 11 CIN III Yes 16 1270254 1270254 G A nonsynonymous_SNV CACNA1H:NM_001005407:exon34:c.G6304A:p.A2102T

CBLB 11 CIN III Yes 3 105421035 105421035 G A nonsynonymous_SNV CBLB:NM_170662:exon12:c.C1862T:p.A621V

DRD3 11 CIN III Yes 3 113858393 113858393 C T nonsynonymous_SNV DRD3:NM_000796:exon5:c.G677A:p.R226Q

EPHA10 11 CIN III Yes 1 38184091 38184091 G A synonymous_SNV EPHA10:NM_001099439:exon17:c.C2980T:p.L994L

FLT1 11 CIN III Yes 13 28891686 28891686 C T nonsynonymous_SNV FLT1:NM_002019:exon25:c.G3335A:p.R1112H

HLTF 11 CIN III Yes 3 148782612 148782612 G T nonsynonymous_SNV HLTF:NM_003071:exon9:c.C1032A:p.N344K

PIK3CA 11 CIN III Yes 3 178936091 178936091 G A nonsynonymous_SNV p.E545K

SLC25A31 11 CIN III Yes 4 128688293 128688293 G T nonsynonymous_SNV SLC25A31:NM_031291:exon4:c.G551T:p.G184V

SMAD2 11 CIN III Yes 18 45395636 45395636 G C nonsynonymous_SNV SMAD2:NM_001135937:exon3:c.C408G:p.H136Q

SMARCD1 11 CIN III Yes 12 50480132 50480132 G T splicing mutation SMARCD1(NM_003076:exon2:c.365+1G>T

SRM 11 CIN III Yes 1 11115981 11115981 C T nonsynonymous_SNV SRM:NM_003132:exon6:c.G622A:p.E208K

TP53 11 CIN III Yes 17 7577120 7577120 C T nonsynonymous_SNV TP53:NM_001126115:exon4:c.G422A:p.R141H

ABL2 13 MSI-H II No 1 179077900 179077900 T - frameshift_deletion ABL2:NM_001168236:exon11:c.2439delA:p.P813fs

ACVR1 13 MSI-H II No 2 158622516 158622516 C T nonsynonymous_SNV ACVR1:NM_001105:exon8:c.G983A:p.G328E

ACVR2A 13 MSI-H II No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ADH1C 13 MSI-H II No 4 100266156 100266156 C T unknown UNKNOWN AKAP12 13 MSI-H II No 6 151671106 151671106 A - frameshift_deletion AKAP12:NM_144497:exon2:c.1286delA:p.K429fs

AKAP13 13 MSI-H II No 15 86124487 86124488 CT - frameshift_deletion AKAP13:NM_006738:exon7:c.3188_3189del:p.1063_1063del

AKAP13 13 MSI-H II No 15 86124490 86124490 C - frameshift_deletion AKAP13:NM_006738:exon7:c.3191delC:p.P1064fs

AKAP7 13 MSI-H II No 6 131602740 131602740 G A synonymous_SNV AKAP7:NM_004842:exon2:c.G120A:p.A40A

AKAP8 13 MSI-H II No 19 15483837 15483837 T C nonsynonymous_SNV AKAP8:NM_005858:exon5:c.A686G:p.Y229C

AKT3 13 MSI-H II No 1 243736301 243736301 C T nonsynonymous_SNV AKT3:NM_005465:exon8:c.G746A:p.R249H

ALDH1L1 13 MSI-H II No 3 125877320 125877320 G - frameshift_deletion ALDH1L1:NM_001270364:exon3:c.320delC:p.A107fs

ALK 13 MSI-H II No 2 29416536 29416536 - C frameshift_insertion ALK:NM_004304:exon29:c.4417dupG:p.G1473fs

AP4E1 13 MSI-H II No 15 51200978 51200978 G T nonsynonymous_SNV AP4E1:NM_007347:exon1:c.G3T:p.M1I

APC 13 MSI-H II No 5 112163705 112163705 T C splicing mutation APC(NM_001127511:exon11:c.1572+2T>C

APC 13 MSI-H II No 5 112163631 112163631 G A synonymous_SNV APC:NM_001127511:exon11:c.G1500A:p.T500T

APC2 13 MSI-H II No 19 1468975 1468975 C - frameshift_deletion APC2:NM_005883:exon15:c.5675delC:p.P1892fs

ARID1B 13 MSI-H II No 6 157222554 157222554 G A synonymous_SNV ARID1B:NM_017519:exon3:c.G1782A:p.Q594Q

ATP2A2 13 MSI-H II No 12 110780240 110780240 G A nonsynonymous_SNV ATP2A2:NM_001681:exon15:c.G2305A:p.G769R

ATP2A3 13 MSI-H II No 17 3844909 3844909 G A nonsynonymous_SNV ATP2A3:NM_005173:exon13:c.C1585T:p.R529C

ATP2A3 13 MSI-H II No 17 3848045 3848045 C T nonsynonymous_SNV ATP2A3:NM_005173:exon10:c.G1240A:p.A414T

ATP2A3 13 MSI-H II No 17 3851047 3851047 C T nonsynonymous_SNV ATP2A3:NM_005173:exon8:c.G733A:p.E245K

ATR 13 MSI-H II No 3 142274749 142274749 T - frameshift_deletion ATR:NM_001184:exon10:c.2311delA:p.K771fs

AXIN1 13 MSI-H II No 16 348082 348082 A G nonsynonymous_SNV AXIN1:NM_003502:exon6:c.T1424C:p.V475A

AXL 13 MSI-H II No 19 41743939 41743939 C - frameshift_deletion AXL:NM_001699:exon7:c.874delC:p.H292fs

BMPR1A 13 MSI-H II No 10 88681434 88681434 C T nonsynonymous_SNV BMPR1A:NM_004329:exon11:c.C1324T:p.R442C

BMPR2 13 MSI-H II No 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BRAF 13 MSI-H II No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1B 13 MSI-H II No 9 140941438 140941438 G A nonsynonymous_SNV CACNA1B:NM_000718:exon22:c.G3496A:p.A1166T

CACNA1E 13 MSI-H II No 1 181685252 181685252 T C synonymous_SNV CACNA1E:NM_000721:exon10:c.T1302C:p.D434D

CACNA1G 13 MSI-H II No 17 48703869 48703869 G - frameshift_deletion CACNA1G:NM_198387:exon34:c.6510delG:p.G2170fs

CACNA1G 13 MSI-H II No 17 48703926 48703926 - C frameshift_insertion CACNA1G:NM_198387:exon34:c.6567dupC:p.P2189fs

CACNA1G 13 MSI-H II No 17 48669200 48669200 G A nonsynonymous_SNV CACNA1G:NM_001256324:exon12:c.G2740A:p.V914I

CACNA1I 13 MSI-H II No 22 40081813 40081813 G A synonymous_SNV CACNA1I:NM_001003406:exon36:c.G5970A:p.A1990A

CACNA1S 13 MSI-H II No 1 201020250 201020250 C T stopgain_SNV CACNA1S:NM_000069:exon33:c.G3975A:p.W1325X

CAMK2B 13 MSI-H II No 7 44260485 44260485 A T nonsynonymous_SNV CAMK2B:NM_172084:exon13:c.T962A:p.I321N

CAMK2D 13 MSI-H II No 4 114378551 114378551 C A nonsynonymous_SNV CAMK2D:NM_001221:exon17:c.G1373T:p.R458L

CDH1 13 MSI-H II No 16 68771335 68771335 G T nonsynonymous_SNV CDH1:NM_004360:exon1:c.G17T:p.R6L

CDH20 13 MSI-H II No 18 59221582 59221582 G A nonsynonymous_SNV CDH20:NM_031891:exon11:c.G2060A:p.R687Q CHD2 13 MSI-H II No 15 93540325 93540325 A - frameshift_deletion CHD2:NM_001271:exon29:c.3734delA:p.K1245fs

CHD3 13 MSI-H II No 17 7798771 7798771 C - frameshift_deletion CHD3:NM_001005271:exon10:c.1795delC:p.R599fs

CHD3 13 MSI-H II No 17 7814815 7814817 AGG - nonframeshift_deletion CHD3:NM_005852:exon39:c.5813_5815del:p.1938_1939del

CHD7 13 MSI-H II No 8 61769283 61769283 A C nonsynonymous_SNV CHD7:NM_017780:exon34:c.A7444C:p.M2482L

CTNND2 13 MSI-H II No 5 11903957 11903957 C T synonymous_SNV CTNND2:NM_001332:exon1:c.G9A:p.A3A

DNMT1 13 MSI-H II No 19 10267172 10267172 G A nonsynonymous_SNV DNMT1:NM_001379:exon17:c.C1246T:p.H416Y

DNMT3A 13 MSI-H II No 2 25467159 25467159 G T synonymous_SNV DNMT3A:NM_153759:exon11:c.C1149A:p.A383A

DOCK3 13 MSI-H II No 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

DPF3 13 MSI-H II No 14 73159877 73159877 A G nonsynonymous_SNV DPF3:NM_012074:exon7:c.T649C:p.Y217H

DPF3 13 MSI-H II No 14 73238509 73238509 A G nonsynonymous_SNV DPF3:NM_012074:exon2:c.T125C:p.L42P

DPP10 13 MSI-H II No 2 116447427 116447427 A T nonsynonymous_SNV DPP10:NM_001004360:exon7:c.A485T:p.E162V

DPP10 13 MSI-H II No 2 116548862 116548862 G A splicing mutation DPP10(NM_020868:exon19:c.1631-1G>A

DPYS 13 MSI-H II No 8 105479143 105479143 C T synonymous_SNV DPYS:NM_001385:exon1:c.G6A:p.A2A

DVL3 13 MSI-H II No 3 183888404 183888404 C - frameshift_deletion DVL3:NM_004423:exon15:c.2012delC:p.P671fs

EGFR 13 MSI-H II No 7 55214319 55214319 C T nonsynonymous_SNV EGFR:NM_005228:exon4:c.C445T:p.R149W

EGFR 13 MSI-H II No 7 55224354 55224354 T C splicing mutation EGFR(NM_201284:exon9:c.1133+2T>C

EP400 13 MSI-H II No 12 132547096 132547097 GC - frameshift_deletion EP400:NM_015409:exon47:c.8184_8185del:p.2728_2729del

EP400 13 MSI-H II No 12 132547099 132547099 G - frameshift_deletion EP400:NM_015409:exon47:c.8187delG:p.Q2729fs

EPHA1 13 MSI-H II No 7 143090789 143090789 G A nonsynonymous_SNV EPHA1:NM_005232:exon16:c.C2671T:p.R891W

EPHA2 13 MSI-H II No 1 16474982 16474982 C - frameshift_deletion EPHA2:NM_004431:exon3:c.714delG:p.P238fs

EPHA3 13 MSI-H II No 3 89499368 89499368 C - frameshift_deletion EPHA3:NM_005233:exon15:c.2538delC:p.P846fs

EPHA5 13 MSI-H II No 4 66213916 66213916 T - frameshift_deletion EPHA5:NM_182472:exon14:c.2448delA:p.G816fs

EPHA7 13 MSI-H II No 6 93953227 93953227 C A nonsynonymous_SNV EPHA7:NM_004440:exon17:c.G2914T:p.G972C

EPHA7 13 MSI-H II No 6 94128980 94128980 G A nonsynonymous_SNV EPHA7:NM_004440:exon1:c.C80T:p.A27V

EPHB2 13 MSI-H II No 1 23191514 23191514 C T nonsynonymous_SNV EPHB2:NM_004442:exon5:c.C1112T:p.A371V

EPHB2 13 MSI-H II No 1 23222920 23222920 C T nonsynonymous_SNV EPHB2:NM_004442:exon9:c.C1717T:p.R573C

FBXW7 13 MSI-H II No 4 153253807 153253807 C T nonsynonymous_SNV FBXW7:NM_001013415:exon5:c.G572A:p.R191H

FGFR4 13 MSI-H II No 5 176519694 176519694 C T synonymous_SNV FGFR4:NM_022963:exon7:c.C966T:p.N322N

FNDC1 13 MSI-H II No 6 159636058 159636058 G A nonsynonymous_SNV FNDC1:NM_032532:exon5:c.G542A:p.R181H

FRK 13 MSI-H II No 6 116263681 116263681 C T nonsynonymous_SNV FRK:NM_002031:exon8:c.G1414A:p.A472T

GNAS 13 MSI-H II No 20 57429876 57429876 C T nonsynonymous_SNV GNAS:NM_001077490:exon1:c.C1369T:p.P457S

GRIN1 13 MSI-H II No 9 140042613 140042613 A - frameshift_deletion GRIN1:NM_001185090:exon4:c.580delA:p.R194fs

HCFC1 13 MSI-H II No X 153230101 153230101 G A synonymous_SNV HCFC1:NM_005334:exon2:c.C270T:p.D90D

HCFC2 13 MSI-H II No 12 104476542 104476542 A - frameshift_deletion HCFC2:NM_013320:exon7:c.926delA:p.N309fs HDAC2 13 MSI-H II No 6 114292048 114292048 T - frameshift_deletion HDAC2:NM_001527:exon1:c.25delA:p.K9fs

HDAC6 13 MSI-H II No X 48673858 48673858 C A nonsynonymous_SNV HDAC6:NM_006044:exon15:c.C1217A:p.P406H

HGF 13 MSI-H II No 7 81372731 81372731 C A nonsynonymous_SNV HGF:NM_000601:exon7:c.G803T:p.R268M

HSP90B1 13 MSI-H II No 12 104337029 104337029 C T nonsynonymous_SNV HSP90B1:NM_003299:exon13:c.C1822T:p.R608C

JAK1 13 MSI-H II No 1 65307004 65307004 T - frameshift_deletion JAK1:NM_002227:exon19:c.2573delA:p.E858fs

JAK3 13 MSI-H II No 19 17945970 17945970 G A nonsynonymous_SNV JAK3:NM_000215:exon15:c.C1969T:p.R657W

JARID2 13 MSI-H II No 6 15496728 15496728 G - frameshift_deletion JARID2:NM_001267040:exon7:c.756delG:p.G252fs

JARID2 13 MSI-H II No 6 15513226 15513226 A - frameshift_deletion JARID2:NM_001267040:exon15:c.2700delA:p.K900fs

JARID2 13 MSI-H II No 6 15497092 15497092 G A nonsynonymous_SNV JARID2:NM_001267040:exon7:c.G1120A:p.G374S

JMJD1C 13 MSI-H II No 10 64957233 64957233 - T frameshift_insertion JMJD1C:NM_004241:exon10:c.4925dupA:p.Q1642fs

JMJD1C 13 MSI-H II No 10 64928301 64928301 T C nonsynonymous_SNV JMJD1C:NM_004241:exon22:c.A6716G:p.Q2239R

KAT2A 13 MSI-H II No 17 40273195 40273195 G - frameshift_deletion KAT2A:NM_021078:exon1:c.128delC:p.T43fs

KDM5B 13 MSI-H II No 1 202711611 202711611 A G nonsynonymous_SNV KDM5B:NM_006618:exon18:c.T2497C:p.S833P

KDM6A 13 MSI-H II No X 44922672 44922674 ACC - nonframeshift_deletion KDM6A:NM_021140:exon16:c.1533_1535del:p.511_512del

KDM6B 13 MSI-H II No 17 7751886 7751886 C - frameshift_deletion KDM6B:NM_001080424:exon11:c.2280delC:p.T760fs

KDM6B 13 MSI-H II No 17 7755468 7755468 C T nonsynonymous_SNV KDM6B:NM_001080424:exon19:c.C4282T:p.H1428Y

MAP2K7 13 MSI-H II No 19 7977033 7977033 G T splicing mutation MAP2K7(NM_145185:exon10:c.1080-1G>T)

MAP3K1 13 MSI-H II No 5 56178577 56178579 GAA - nonframeshift_deletion MAP3K1:NM_005921:exon14:c.3550_3552del:p.1184_1184del

MAPK3 13 MSI-H II No 16 30134510 30134510 C - frameshift_deletion MAPK3:NM_001040056:exon1:c.21delG:p.Q7fs

MAPK8IP2 13 MSI-H II No 22 51042455 51042455 C T unknown UNKNOWN

MLL4 13 MSI-H II No 19 36213625 36213625 G A splicing mutation MLL4(NM_014727:exon5:c.2722+5G>A)

MMP2 13 MSI-H II No 16 55532321 55532321 - A frameshift_insertion MMP2:NM_001127891:exon11:c.1580dupA:p.N527fs

MRE11A 13 MSI-H II No 11 94192702 94192702 C G nonsynonymous_SNV MRE11A:NM_005590:exon13:c.G1372C:p.V458L

MSH6 13 MSI-H II No 2 48032773 48032773 - T frameshift_insertion MSH6:NM_000179:exon7:c.3573dupT:p.F1191fs

MTHFD1 13 MSI-H II No 14 64909112 64909112 G A nonsynonymous_SNV MTHFD1:NM_005956:exon21:c.G2128A:p.G710S

MTHFD1 13 MSI-H II No 14 64916162 64916162 G T splicing mutation MTHFD1(NM_005956:exon24:c.2280-1G>T)

NRAS 13 MSI-H II No 1 115251236 115251236 G A nonsynonymous_SNV NRAS:NM_002524:exon5:c.C490T:p.R164C

NRAS 13 MSI-H II No 1 115252265 115252265 A G synonymous_SNV NRAS:NM_002524:exon4:c.T375C:p.V125V

P2RX7 13 MSI-H II No 12 121592720 121592720 T C synonymous_SNV P2RX7:NM_002562:exon2:c.T258C:p.S86S

PIAS3 13 MSI-H II No 1 145584539 145584539 G A synonymous_SNV PIAS3:NM_006099:exon12:c.G1506A:p.T502T

PIK3C2G 13 MSI-H II No 12 18478016 18478016 A G nonsynonymous_SNV PIK3C2G:NM_004570:exon8:c.A1256G:p.Y419C

PIK3R1 13 MSI-H II No 5 67522723 67522723 G A nonsynonymous_SNV PIK3R1:NM_181523:exon2:c.G220A:p.V74I

PRKDC 13 MSI-H II No 8 48695047 48695047 C T unknown UNKNOWN

PRKDC 13 MSI-H II No 8 48866919 48866919 - T unknown UNKNOWN PTPN23 13 MSI-H II No 3 47451537 47451537 C - frameshift_deletion PTPN23:NM_015466:exon20:c.2249delC:p.P750fs

PTPRF 13 MSI-H II No 1 44063568 44063568 G A nonsynonymous_SNV PTPRF:NM_002840:exon12:c.G1963A:p.G655R

PTPRG 13 MSI-H II No 3 62204534 62204534 A - frameshift_deletion PTPRG:NM_002841:exon13:c.2165delA:p.N722fs

PTPRH 13 MSI-H II No 19 55715310 55715310 G A synonymous_SNV PTPRH:NM_002842:exon5:c.C726T:p.C242C

PTPRM 13 MSI-H II No 18 8379225 8379225 C - frameshift_deletion PTPRM:NM_002845:exon26:c.3634delC:p.R1212fs

PTPRS 13 MSI-H II No 19 5238995 5238995 G A nonsynonymous_SNV PTPRS:NM_130853:exon10:c.C1745T:p.A582V

RASA1 13 MSI-H II No 5 86685317 86685317 G A synonymous_SNV RASA1:NM_002890:exon24:c.G3033A:p.T1011T

RASGRF1 13 MSI-H II No 15 79265643 79265643 A G splicing mutation RASGRF1(NM_001145648:exon26:c.3612+2T>C

RASGRP1 13 MSI-H II No 15 38794602 38794602 A G synonymous_SNV RASGRP1:NM_001128602:exon11:c.T1344C:p.D448D

RASGRP2 13 MSI-H II No 11 64508422 64508422 G A synonymous_SNV RASGRP2:NM_001098670:exon5:c.C369T:p.S123S

RET 13 MSI-H II No 10 43604649 43604649 G A nonsynonymous_SNV RET:NM_020630:exon6:c.G1234A:p.V412M

RPS6KB2 13 MSI-H II No 11 67202064 67202064 C T synonymous_SNV RPS6KB2:NM_003952:exon14:c.C1167T:p.Y389Y

RPTOR 13 MSI-H II No 17 78921053 78921053 A C nonsynonymous_SNV RPTOR:NM_001163034:exon23:c.A2693C:p.K898T

RPTOR 13 MSI-H II No 17 78681725 78681725 C T stopgain_SNV RPTOR:NM_001163034:exon4:c.C433T:p.R145X

RYR1 13 MSI-H II No 19 38993186 38993186 C T nonsynonymous_SNV RYR1:NM_000540:exon48:c.C7654T:p.R2552C

RYR1 13 MSI-H II No 19 38993229 38993229 C T nonsynonymous_SNV RYR1:NM_000540:exon48:c.C7697T:p.A2566V

SETD1A 13 MSI-H II No 16 30977323 30977323 - C frameshift_insertion SETD1A:NM_014712:exon8:c.2121dupC:p.P707fs

SETD1B 13 MSI-H II No 12 122260894 122260894 C T nonsynonymous_SNV SETD1B:NM_015048:exon12:c.C4280T:p.T1427M

SHC1 13 MSI-H II No 1 154942917 154942917 G - frameshift_deletion SHC1:NM_001130040:exon1:c.86delC:p.T29fs

SMAD7 13 MSI-H II No 18 46476633 46476633 G A synonymous_SNV SMAD7:NM_001190821:exon1:c.C162T:p.G54G

SMARCA2 13 MSI-H II No 9 2087011 2087011 - T frameshift_insertion SMARCA2:NM_003070:exon18:c.2709dupT:p.F903fs

SMARCA5 13 MSI-H II No 4 144459999 144459999 C T nonsynonymous_SNV SMARCA5:NM_003601:exon13:c.C1678T:p.R560C

STAT5A 13 MSI-H II No 17 40462679 40462680 CT - frameshift_deletion STAT5A:NM_003152:exon20:c.2377_2378del:p.793_793del

STAT5B 13 MSI-H II No 17 40353772 40353772 G A nonsynonymous_SNV STAT5B:NM_012448:exon19:c.C2348T:p.P783L

STK11 13 MSI-H II No 19 1221992 1221992 A T nonsynonymous_SNV STK11:NM_000455:exon7:c.A907T:p.I303F

SYNGAP1 13 MSI-H II No 6 33409063 33409063 G A nonsynonymous_SNV SYNGAP1:NM_006772:exon12:c.G2027A:p.S676N

SYNGAP1 13 MSI-H II No 6 33410817 33410817 C T nonsynonymous_SNV SYNGAP1:NM_006772:exon15:c.C2488T:p.P830S

TCF7L2 13 MSI-H II No 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TGFBR2 13 MSI-H II No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

TRDN 13 MSI-H II No 6 123673681 123673681 T - frameshift_deletion TRDN:NM_001251987:exon21:c.1375delA:p.K459fs

TRDN 13 MSI-H II No 6 123786042 123786042 A - frameshift_deletion TRDN:NM_001256020:exon9:c.880delT:p.F294fs

TSC1 13 MSI-H II No 9 135772728 135772728 G A stopgain_SNV TSC1:NM_001162427:exon21:c.C2665T:p.Q889X

TYK2 13 MSI-H II No 19 10468592 10468592 G A nonsynonymous_SNV TYK2:NM_003331:exon17:c.C2314T:p.R772W

ULK1 13 MSI-H II No 12 132393351 132393351 G A nonsynonymous_SNV ULK1:NM_003565:exon6:c.G479A:p.R160H ZNF521 13 MSI-H II No 18 22806329 22806329 C A nonsynonymous_SNV ZNF521:NM_015461:exon4:c.G1553T:p.C518F

APC 15 CIN II No 5 112175247 112175247 C - frameshift_deletion APC:NM_001127511:exon14:c.3902delC:p.P1301fs

APC 15 CIN II No 5 112176701 112176701 G C nonsynonymous_SNV APC:NM_001127511:exon14:c.G5356C:p.V1786L

GRIN2A 15 CIN II No 16 9857312 9857312 G A synonymous_SNV GRIN2A:NM_001134407:exon13:c.C4089T:p.S1363S

NAV3 15 CIN II No 12 78400614 78400614 T C synonymous_SNV NAV3:NM_014903:exon8:c.T1296C:p.S432S

ABL2 17 MSI-H II No 1 179077233 179077233 - T frameshift_insertion ABL2:NM_001168236:exon11:c.3106dupA:p.K1036fs

ABL2 17 MSI-H II No 1 179090952 179090952 G T nonsynonymous_SNV ABL2:NM_001136001:exon4:c.C675A:p.H225Q

ACVR2A 17 MSI-H II No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

AKAP1 17 MSI-H II No 17 55184303 55184303 A G nonsynonymous_SNV AKAP1:NM_003488:exon2:c.A1478G:p.D493G

AKAP11 17 MSI-H II No 13 42875827 42875827 C A nonsynonymous_SNV AKAP11:NM_016248:exon8:c.C2945A:p.P982Q

AKAP2,PALM2-AKAP2 17 MSI-H II No 9 112899773 112899773 G A nonsynonymous_SNV AKAP2:NM_001004065:exon2:c.G1523A:p.S508N

AKAP9 17 MSI-H II No 7 91632452 91632452 A G nonsynonymous_SNV AKAP9:NM_005751:exon8:c.A3221G:p.H1074R

AKAP9 17 MSI-H II No 7 91624044 91624044 T - stopgain_SNV AKAP9:NM_005751:exon6:c.686delT:p.L229X

ALDH1L1 17 MSI-H II No 3 125855672 125855672 - C frameshift_insertion ALDH1L1:NM_001270365:exon9:c.976dupG:p.G326fs

APC2 17 MSI-H II No 19 1465190 1465190 G A synonymous_SNV APC2:NM_005883:exon15:c.G1890A:p.L630L

ARID1A 17 MSI-H II No 1 27089463 27089463 G T splicing mutation ARID1A(NM_006015:exon8:c.2420-1G>T

ATP2A2 17 MSI-H II No 12 110780058 110780058 C T nonsynonymous_SNV ATP2A2:NM_001681:exon15:c.C2123T:p.P708L

ATP2B3 17 MSI-H II No X 152827637 152827637 A - frameshift_deletion ATP2B3:NM_001001344:exon18:c.3096delA:p.P1032fs

ATP2B3 17 MSI-H II No X 152815141 152815141 C T nonsynonymous_SNV ATP2B3:NM_001001344:exon9:c.C1525T:p.L509F

ATP2B3 17 MSI-H II No X 152807225 152807225 C T synonymous_SNV ATP2B3:NM_001001344:exon3:c.C505T:p.L169L

ATP2B4 17 MSI-H II No 1 203676274 203676274 G A nonsynonymous_SNV ATP2B4:NM_001001396:exon9:c.G1237A:p.G413S

AXIN2 17 MSI-H II No 17 63533180 63533180 C T nonsynonymous_SNV AXIN2:NM_004655:exon7:c.G1714A:p.G572S

BMPR2 17 MSI-H II No 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BMPR2 17 MSI-H II No 2 203329579 203329579 C T stopgain_SNV BMPR2:NM_001204:exon2:c.C124T:p.Q42X

BRAF 17 MSI-H II No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1B 17 MSI-H II No 9 140850190 140850190 G A nonsynonymous_SNV CACNA1B:NM_000718:exon8:c.G1111A:p.A371T

CACNA1C 17 MSI-H II No 12 2795367 2795367 C T stopgain_SNV CACNA1C:NM_001129837:exon44:c.C5740T:p.R1914X

CACNA1E 17 MSI-H II No 1 181706743 181706743 G A nonsynonymous_SNV CACNA1E:NM_001205294:exon22:c.G3448A:p.A1150T

CACNA1H 17 MSI-H II No 16 1259227 1259227 G A nonsynonymous_SNV CACNA1H:NM_001005407:exon17:c.G3559A:p.G1187R

CACNA1I 17 MSI-H II No 22 40037071 40037071 G A nonsynonymous_SNV CACNA1I:NM_001003406:exon6:c.G940A:p.G314S

CACNA1I 17 MSI-H II No 22 40057152 40057152 A G nonsynonymous_SNV CACNA1I:NM_001003406:exon15:c.A2633G:p.H878R

CACNA2D4 17 MSI-H II No 12 1955765 1955765 G A synonymous_SNV CACNA2D4:NM_172364:exon24:c.C2337T:p.S779S

CALM1 17 MSI-H II No 14 90870303 90870303 C T synonymous_SNV CALM1:NM_006888:exon4:c.C276T:p.V92V

CALR 17 MSI-H II No 19 13054402 13054402 T A nonsynonymous_SNV CALR:NM_004343:exon8:c.T1012A:p.Y338N CASQ1 17 MSI-H II No 1 160163580 160163580 A C nonsynonymous_SNV CASQ1:NM_001231:exon3:c.A408C:p.E136D

CBL 17 MSI-H II No 11 119149355 119149355 - ATG nonframeshift_insertion CBL:NM_005188:exon9:c.1363_1364insATG:p.Y455delinsYD

CHD3 17 MSI-H II No 17 7810691 7810691 C A synonymous_SNV CHD3:NM_001005271:exon32:c.C4986A:p.A1662A

CHD4 17 MSI-H II No 12 6711552 6711552 T - frameshift_deletion CHD4:NM_001273:exon3:c.212delA:p.Q71fs

CHD5 17 MSI-H II No 1 6196698 6196698 A - frameshift_deletion CHD5:NM_015557:exon17:c.2575delT:p.F859fs

CHD5 17 MSI-H II No 1 6206474 6206474 A G nonsynonymous_SNV CHD5:NM_015557:exon11:c.T1600C:p.Y534H

CHD6 17 MSI-H II No 20 40050708 40050708 T C nonsynonymous_SNV CHD6:NM_032221:exon31:c.A4567G:p.T1523A

CREBBP 17 MSI-H II No 16 3900465 3900465 C A stopgain_SNV CREBBP:NM_001079846:exon2:c.G631T:p.G211X

CREBBP 17 MSI-H II No 16 3778724 3778724 G A synonymous_SNV CREBBP:NM_001079846:exon30:c.C6210T:p.Y2070Y

CTNNA1 17 MSI-H II No 5 138163408 138163408 G A splicing mutation CTNNA1(NM_001903:exon7:c.1062+1G>A)

DDR1 17 MSI-H II No 6 30865339 30865339 T C synonymous_SNV DDR1:NM_001202522:exon12:c.T1743C:p.P581P

DNAH3 17 MSI-H II No 16 20975136 20975136 A G nonsynonymous_SNV DNAH3:NM_017539:exon53:c.T10070C:p.I3357T

DNAH3 17 MSI-H II No 16 20970611 20970611 G A synonymous_SNV DNAH3:NM_017539:exon54:c.C10716T:p.D3572D

DNMT1 17 MSI-H II No 19 10260210 10260210 T C synonymous_SNV DNMT1:NM_001379:exon25:c.A2457G:p.E819E

DOCK3 17 MSI-H II No 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

DPF1 17 MSI-H II No 19 38713195 38713195 G A synonymous_SNV DPF1:NM_001135155:exon2:c.C264T:p.R88R

DPYD 17 MSI-H II No 1 98386474 98386474 G - frameshift_deletion DPYD:NM_000110:exon1:c.5delC:p.A2fs

DVL2 17 MSI-H II No 17 7132917 7132917 C T nonsynonymous_SNV DVL2:NM_004422:exon6:c.G737A:p.R246H

EGFR 17 MSI-H II No 7 55266547 55266547 A G nonsynonymous_SNV EGFR:NM_005228:exon23:c.A2839G:p.M947V

EP400 17 MSI-H II No 12 132504762 132504762 A - frameshift_deletion EP400:NM_015409:exon22:c.4446delA:p.K1482fs

EP400 17 MSI-H II No 12 132539520 132539520 C T nonsynonymous_SNV EP400:NM_015409:exon44:c.C7730T:p.A2577V

EPHA1 17 MSI-H II No 7 143091392 143091392 G T synonymous_SNV EPHA1:NM_005232:exon15:c.C2397A:p.A799A

EPHA5 17 MSI-H II No 4 66467578 66467578 - T frameshift_insertion EPHA5:NM_004439:exon3:c.691dupA:p.K231fs

EPHB3 17 MSI-H II No 3 184294839 184294839 C T nonsynonymous_SNV EPHB3:NM_004443:exon5:c.C1222T:p.R408C

EPHB3 17 MSI-H II No 3 184295169 184295169 T G nonsynonymous_SNV EPHB3:NM_004443:exon6:c.T1393G:p.S465A

HDAC6 17 MSI-H II No X 48681647 48681647 C A synonymous_SNV HDAC6:NM_006044:exon25:c.C2838A:p.A946A

HDAC6 17 MSI-H II No X 48682472 48682472 C T synonymous_SNV HDAC6:NM_006044:exon27:c.C3444T:p.C1148C

IKBKAP 17 MSI-H II No 9 111662567 111662567 C T synonymous_SNV IKBKAP:NM_003640:exon19:c.G2103A:p.V701V

IRS1 17 MSI-H II No 2 227661138 227661138 G A nonsynonymous_SNV IRS1:NM_005544:exon1:c.C2317T:p.H773Y

ITPR2 17 MSI-H II No 12 26749905 26749905 T - frameshift_deletion ITPR2:NM_002223:exon31:c.4165delA:p.K1389fs

ITPR2 17 MSI-H II No 12 26808766 26808766 A T nonsynonymous_SNV ITPR2:NM_002223:exon20:c.T2464A:p.S822T

JMJD1C 17 MSI-H II No 10 64952706 64952706 T - frameshift_deletion JMJD1C:NM_004241:exon13:c.5357delA:p.E1786fs

KDM3B 17 MSI-H II No 5 137765600 137765600 A G synonymous_SNV KDM3B:NM_016604:exon21:c.A4839G:p.L1613L

KDM5A 17 MSI-H II No 12 416960 416960 T - frameshift_deletion KDM5A:NM_001042603:exon23:c.3590delA:p.Q1197fs KIAA0825 17 MSI-H II No 5 93732096 93732096 T - frameshift_deletion KIAA0825:NM_001145678:exon17:c.3006delA:p.S1002fs

LMTK2 17 MSI-H II No 7 97800901 97800901 - G frameshift_insertion LMTK2:NM_014916:exon7:c.706dupG:p.D236fs

MAP2K3 17 MSI-H II No 17 21203940 21203940 C T synonymous_SNV MAP2K3:NM_002756:exon4:c.C162T:p.H54H

MET 17 MSI-H II No 7 116414971 116414971 G A nonsynonymous_SNV MET:NM_000245:exon15:c.G3065A:p.R1022Q

MLH1 17 MSI-H II No 3 37067174 37067174 C A nonsynonymous_SNV MLH1:NM_001167619:exon11:c.C362A:p.S121Y

MLL 17 MSI-H II No 11 118376803 118376803 C A nonsynonymous_SNV MLL:NM_001197104:exon27:c.C10196A:p.P3399H

MLL2 17 MSI-H II No 12 49434908 49434908 T C synonymous_SNV MLL2:NM_003482:exon31:c.A6645G:p.S2215S

MLL3 17 MSI-H II No 7 151873975 151873975 G A stopgain_SNV MLL3:NM_170606:exon38:c.C8563T:p.Q2855X

MLL4 17 MSI-H II No 19 36218456 36218456 G - frameshift_deletion MLL4:NM_014727:exon16:c.4235delG:p.G1412fs

MLL5 17 MSI-H II No 7 104730633 104730633 T C synonymous_SNV MLL5:NM_018682:exon13:c.T1536C:p.D512D

MST1R 17 MSI-H II No 3 49940516 49940516 T C nonsynonymous_SNV MST1R:NM_001244937:exon1:c.A527G:p.D176G

MTHFS,ST20-MTHFS 17 MSI-H II No 15 80137600 80137600 G A synonymous_SNV MTHFS:NM_001199758:exon3:c.C393T:p.N131N

MTOR 17 MSI-H II No 1 11319407 11319407 G A synonymous_SNV MTOR:NM_004958:exon2:c.C60T:p.S20S

MTR 17 MSI-H II No 1 237023202 237023202 C A nonsynonymous_SNV MTR:NM_000254:exon19:c.C2023A:p.L675I

MUSK 17 MSI-H II No 9 113459699 113459699 A - frameshift_deletion MUSK:NM_001166280:exon5:c.581delA:p.N194fs

NR4A1 17 MSI-H II No 12 52452682 52452682 C - frameshift_deletion NR4A1:NM_173157:exon7:c.1751delC:p.P584fs

NR4A1 17 MSI-H II No 12 52451038 52451038 G A synonymous_SNV NR4A1:NM_173157:exon5:c.G1356A:p.A452A

NTRK1 17 MSI-H II No 1 156830829 156830829 C T nonsynonymous_SNV NTRK1:NM_001012331:exon1:c.C103T:p.P35S

NTRK3 17 MSI-H II No 15 88420270 88420270 A G nonsynonymous_SNV NTRK3:NM_001243101:exon18:c.T2350C:p.C784R

P2RX2 17 MSI-H II No 12 133197128 133197128 G A nonsynonymous_SNV P2RX2:NM_012226:exon5:c.G517A:p.V173M

P2RX3 17 MSI-H II No 11 57135558 57135558 C T synonymous_SNV P2RX3:NM_002559:exon9:c.C918T:p.D306D

P2RX5 17 MSI-H II No 17 3594953 3594953 G A synonymous_SNV P2RX5:NM_001204519:exon2:c.C273T:p.Y91Y

PAK6 17 MSI-H II No 15 40557131 40557131 C T nonsynonymous_SNV PAK6:NM_001276717:exon2:c.C145T:p.R49C

PDK1 17 MSI-H II No 2 173426996 173426996 T C synonymous_SNV PDK1:NM_002610:exon3:c.T387C:p.A129A

PIAS2 17 MSI-H II No 18 44444148 44444148 A C nonsynonymous_SNV PIAS2:NM_004671:exon3:c.T563G:p.V188G

PIK3CA 17 MSI-H II No 3 178936082 178936082 G A nonsynonymous_SNV p.E542K

PIK3CA 17 MSI-H II No 3 178936094 178936094 C A nonsynonymous_SNV p.Q546K

PIK3CA 17 MSI-H II No 3 178927407 178927407 T A nonsynonymous_SNV PIK3CA:NM_006218:exon7:c.T1170A:p.D390E

PIK3CG 17 MSI-H II No 7 106545702 106545702 A - frameshift_deletion PIK3CG:NM_002649:exon11:c.3179delA:p.N1060fs

PIK3R1 17 MSI-H II No 5 67522747 67522747 A - frameshift_deletion PIK3R1:NM_181523:exon2:c.244delA:p.I82fs

PIK3R2 17 MSI-H II No 19 18266796 18266796 C G nonsynonymous_SNV PIK3R2:NM_005027:exon2:c.C107G:p.A36G

PIK3R2 17 MSI-H II No 19 18273303 18273303 A G nonsynonymous_SNV PIK3R2:NM_005027:exon9:c.A1096G:p.T366A

PLCD4 17 MSI-H II No 2 219495439 219495439 G A nonsynonymous_SNV PLCD4:NM_032726:exon9:c.G1186A:p.A396T

PLCE1 17 MSI-H II No 10 95791353 95791353 A G nonsynonymous_SNV PLCE1:NM_016341:exon2:c.A550G:p.R184G PLCG2 17 MSI-H II No 16 81971498 81971498 T C nonsynonymous_SNV PLCG2:NM_002661:exon28:c.T3188C:p.L1063P

PRKDC 17 MSI-H II No 8 48866919 48866919 T - unknown UNKNOWN

PTEN 17 MSI-H II No 10 89717775 89717775 A - frameshift_deletion PTEN:NM_000314:exon7:c.800delA:p.K267fs

PTPN11 17 MSI-H II No 12 112919975 112919975 C T nonsynonymous_SNV PTPN11:NM_002834:exon10:c.C1190T:p.T397M

PTPN22 17 MSI-H II No 1 114377061 114377061 C A nonsynonymous_SNV PTPN22:NM_012411:exon13:c.G1730T:p.G577V

PTPN6 17 MSI-H II No 12 7067135 7067135 T C synonymous_SNV PTPN6:NM_002831:exon11:c.T1260C:p.H420H

PTPRB 17 MSI-H II No 12 70928307 70928307 T C nonsynonymous_SNV PTPRB:NM_001206971:exon28:c.A5405G:p.N1802S

PTPRN 17 MSI-H II No 2 220164731 220164731 T C nonsynonymous_SNV PTPRN:NM_001199763:exon9:c.A1412G:p.Y471C

PTPRS 17 MSI-H II No 19 5220106 5220106 C A nonsynonymous_SNV PTPRS:NM_130853:exon14:c.G2316T:p.E772D

PTPRS 17 MSI-H II No 19 5221061 5221061 G A synonymous_SNV PTPRS:NM_130853:exon12:c.C2112T:p.D704D

RASGRF2 17 MSI-H II No 5 80390723 80390723 T C nonsynonymous_SNV RASGRF2:NM_006909:exon12:c.T1667C:p.V556A

RET 17 MSI-H II No 10 43613913 43613913 G - frameshift_deletion RET:NM_020630:exon13:c.2377delG:p.A793fs

RGS16 17 MSI-H II No 1 182569434 182569434 T C nonsynonymous_SNV RGS16:NM_002928:exon5:c.A602G:p.H201R

RYR1 17 MSI-H II No 19 38995421 38995421 C G nonsynonymous_SNV RYR1:NM_000540:exon51:c.C8101G:p.P2701A

RYR2 17 MSI-H II No 1 237632402 237632402 T G nonsynonymous_SNV RYR2:NM_001035:exon17:c.T1623G:p.I541M

RYR3 17 MSI-H II No 15 33952419 33952419 G A nonsynonymous_SNV RYR3:NM_001036:exon34:c.G4417A:p.A1473T

RYR3 17 MSI-H II No 15 33955759 33955759 C A nonsynonymous_SNV RYR3:NM_001036:exon36:c.C5440A:p.L1814I

RYR3 17 MSI-H II No 15 34047279 34047279 A G nonsynonymous_SNV RYR3:NM_001036:exon58:c.A8413G:p.M2805V

RYR3 17 MSI-H II No 15 33938602 33938602 G A synonymous_SNV RYR3:NM_001036:exon29:c.G3816A:p.T1272T

SETD1B 17 MSI-H II No 12 122242665 122242666 CA - frameshift_deletion SETD1B:NM_015048:exon1:c.22_23del:p.8_8del

SETD1B 17 MSI-H II No 12 122242666 122242666 A - frameshift_deletion SETD1B:NM_015048:exon1:c.23delA:p.H8fs

SETD1B 17 MSI-H II No 12 122246207 122246207 T C nonsynonymous_SNV SETD1B:NM_015048:exon4:c.T638C:p.I213T

SHC4 17 MSI-H II No 15 49135643 49135643 C T synonymous_SNV SHC4:NM_203349:exon10:c.G1446A:p.R482R

SHC4 17 MSI-H II No 15 49254865 49254865 C T synonymous_SNV SHC4:NM_203349:exon1:c.G348A:p.R116R

SHOC2 17 MSI-H II No 10 112724338 112724338 G A synonymous_SNV SHOC2:NM_001269039:exon1:c.G222A:p.R74R

SLC24A2 17 MSI-H II No 9 19516315 19516315 C T nonsynonymous_SNV SLC24A2:NM_001193288:exon9:c.G1771A:p.V591I

SLC25A5 17 MSI-H II No X 118604079 118604079 C T synonymous_SNV SLC25A5:NM_001152:exon2:c.C567T:p.A189A

SLC8A1 17 MSI-H II No 2 40656599 40656599 C T nonsynonymous_SNV SLC8A1:NM_001112800:exon1:c.G822A:p.M274I

SMAD3 17 MSI-H II No 15 67459183 67459183 T C nonsynonymous_SNV SMAD3:NM_001145104:exon2:c.T14C:p.M5T

SMARCA4 17 MSI-H II No 19 11130338 11130338 G A synonymous_SNV SMARCA4:NM_001128845:exon17:c.G2577A:p.T859T

SND1 17 MSI-H II No 7 127724833 127724833 C - frameshift_deletion SND1:NM_014390:exon19:c.2168delC:p.P723fs

SRM 17 MSI-H II No 1 11115039 11115039 G A synonymous_SNV SRM:NM_003132:exon7:c.C868T:p.L290L

STAT2 17 MSI-H II No 12 56737194 56737194 G T synonymous_SNV STAT2:NM_005419:exon24:c.C2535A:p.P845P

SYNGAP1 17 MSI-H II No 6 33411636 33411636 C T nonsynonymous_SNV SYNGAP1:NM_006772:exon15:c.C3307T:p.R1103C TCF7L2 17 MSI-H II No 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TGFBR1 17 MSI-H II No 9 101867491 101867491 G - frameshift_deletion TGFBR1:NM_001130916:exon1:c.4delG:p.E2fs

TGFBR2 17 MSI-H II No 3 30691880 30691881 AA - frameshift_deletion TGFBR2:NM_003242:exon3:c.382_383del:p.128_128del

TIE1 17 MSI-H II No 1 43770699 43770699 G A nonsynonymous_SNV TIE1:NM_001253357:exon2:c.G101A:p.R34H

TNK2 17 MSI-H II No 3 195595355 195595355 G A nonsynonymous_SNV TNK2:NM_005781:exon12:c.C1769T:p.A590V

TRAF2 17 MSI-H II No 9 139818388 139818388 C T nonsynonymous_SNV TRAF2:NM_021138:exon10:c.C1223T:p.S408F

TRRAP 17 MSI-H II No 7 98569513 98569513 T C nonsynonymous_SNV TRRAP:NM_003496:exon51:c.T7709C:p.L2570P

TRRAP 17 MSI-H II No 7 98606157 98606157 G T nonsynonymous_SNV TRRAP:NM_003496:exon68:c.G10782T:p.Q3594H

TSC1 17 MSI-H II No 9 135772957 135772957 T - frameshift_deletion TSC1:NM_001162427:exon20:c.2513delA:p.E838fs

TSC1 17 MSI-H II No 9 135777067 135777067 C A nonsynonymous_SNV TSC1:NM_001162427:exon18:c.G2258T:p.R753M

ZAP70 17 MSI-H II No 2 98340579 98340579 C T nonsynonymous_SNV ZAP70:NM_001079:exon3:c.C80T:p.A27V

ZFYVE9 17 MSI-H II No 1 52803499 52803499 G A synonymous_SNV ZFYVE9:NM_007324:exon15:c.G3549A:p.L1183L

ZNF480 17 MSI-H II No 19 52824858 52824858 G A nonsynonymous_SNV ZNF480:NM_144684:exon5:c.G355A:p.A119T

ACVR1B 19 CIN II No 12 52369112 52369112 G T nonsynonymous_SNV ACVR1B:NM_004302:exon2:c.G155T:p.C52F

APC 19 CIN II No 5 112173917 112173917 C T stopgain_SNV APC:NM_001127511:exon14:c.C2572T:p.R858X

APC 19 CIN II No 5 112175639 112175639 C T stopgain_SNV APC:NM_001127511:exon14:c.C4294T:p.R1432X

CACNA1A 19 CIN II No 19 13318673 13318675 CTG - nonframeshift_deletion CACNA1A:NM_001127222:exon47:c.6973_6975del:p.2325_2325del

CTNNB1 19 CIN II No 3 41278078 41278078 G A splicing mutation CTNNB1(NM_001098209:exon13:c.1955-1G>A

DNMT1 19 CIN II No 19 10265093 10265093 G A nonsynonymous_SNV DNMT1:NM_001379:exon21:c.C1847T:p.T616M

EPHB1 19 CIN II No 3 134670281 134670281 C T synonymous_SNV EPHB1:NM_004441:exon3:c.C192T:p.F64F

FLT4 19 CIN II No 5 180056397 180056397 G A nonsynonymous_SNV FLT4:NM_002020:exon7:c.C847T:p.R283C

GPC5 19 CIN II No 13 92380835 92380835 G A nonsynonymous_SNV GPC5:NM_004466:exon4:c.G1070A:p.R357H

KAT6A 19 CIN II No 8 41790749 41790749 C T synonymous_SNV KAT6A:NM_006766:exon17:c.G4989A:p.P1663P

KRAS 19 CIN II No 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

MAP2K7 19 CIN II No 19 7975000 7975000 A G nonsynonymous_SNV MAP2K7:NM_145185:exon3:c.A319G:p.T107A

PTPRJ 19 CIN II No 11 48149417 48149417 G A synonymous_SNV PTPRJ:NM_001098503:exon7:c.G1179A:p.S393S

PTPRS 19 CIN II No 19 5222130 5222130 G A splicing mutation PTPRS(NM_002850:exon20:c.3201+4C>T

PTPRT 19 CIN II No 20 41100947 41100947 C T nonsynonymous_SNV PTPRT:NM_007050:exon8:c.G1409A:p.R470Q

APC 21 CIN III No 5 112175303 112175303 C T stopgain_SNV APC:NM_001127511:exon14:c.C3958T:p.Q1320X

ARID1A 21 CIN III No 1 27101711 27101711 G T stopgain_SNV ARID1A:NM_006015:exon18:c.G4993T:p.G1665X

ARID2 21 CIN III No 12 46245720 46245720 C T stopgain_SNV ARID2:NM_152641:exon15:c.C3814T:p.R1272X

CBS 21 CIN III No 21 44480586 44480586 G A synonymous_SNV CBS:NM_000071:exon12:c.C1110T:p.C370C

DOCK3 21 CIN III No 3 51274929 51274929 C A synonymous_SNV DOCK3:NM_004947:exon21:c.C2010A:p.I670I

EP300 21 CIN III No 22 41574817 41574817 G A nonsynonymous_SNV EP300:NM_001429:exon31:c.G7102A:p.D2368N FNDC1 21 CIN III No 6 159654679 159654679 G A synonymous_SNV FNDC1:NM_032532:exon11:c.G3135A:p.S1045S

JMJD4 21 CIN III No 1 227920270 227920270 G A synonymous_SNV JMJD4:NM_001161465:exon6:c.C1167T:p.D389D

KAT2B 21 CIN III No 3 20161118 20161118 - G frameshift_insertion KAT2B:NM_003884:exon8:c.1179_1180insG:p.T393fs

KRAS 21 CIN III No 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

MTOR 21 CIN III No 1 11307715 11307715 G A nonsynonymous_SNV MTOR:NM_004958:exon8:c.C1192T:p.R398C

PLCB4 21 CIN III No 20 9440363 9440363 G A nonsynonymous_SNV PLCB4:NM_000933:exon31:c.G3118A:p.D1040N

PTPRT 21 CIN III No 20 40735467 40735467 G A nonsynonymous_SNV PTPRT:NM_007050:exon24:c.C3349T:p.R1117C

ROR2 21 CIN III No 9 94495456 94495456 G A synonymous_SNV ROR2:NM_004560:exon6:c.C885T:p.P295P

ACVR2A 23 CIN III No 2 148672856 148672856 G - frameshift_deletion ACVR2A:NM_001616:exon5:c.625delG:p.A209fs

CACNA1H 23 CIN III No 16 1251808 1251808 C A nonsynonymous_SNV CACNA1H:NM_001005407:exon9:c.C1358A:p.P453H

CACNA1H 23 CIN III No 16 1259211 1259211 C T synonymous_SNV CACNA1H:NM_001005407:exon17:c.C3543T:p.D1181D

ERBB4 23 CIN III No 2 212652788 212652788 G T nonsynonymous_SNV ERBB4:NM_001042599:exon4:c.C518A:p.S173Y

FNDC1 23 CIN III No 6 159653955 159653955 C T nonsynonymous_SNV FNDC1:NM_032532:exon11:c.C2411T:p.T804M

GRIN2C 23 CIN III No 17 72848551 72848551 G C nonsynonymous_SNV GRIN2C:NM_000835:exon3:c.C599G:p.T200R

KRAS 23 CIN III No 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

P2RX7 23 CIN III No 12 121603214 121603214 C G nonsynonymous_SNV P2RX7:NM_002562:exon6:c.C588G:p.I196M

PTPRQ 23 CIN III No 12 80865941 80865941 C A nonsynonymous_SNV PTPRQ:NM_001145026:exon5:c.C581A:p.P194Q

RYR1 23 CIN III No 19 38980011 38980011 A C synonymous_SNV RYR1:NM_000540:exon35:c.A5742C:p.A1914A

RYR2 23 CIN III No 1 237791239 237791239 G A nonsynonymous_SNV RYR2:NM_001035:exon41:c.G6299A:p.R2100Q

STAM 23 CIN III No 10 17756567 17756567 A T nonsynonymous_SNV STAM:NM_003473:exon14:c.A1411T:p.N471Y

TGFBR2 23 CIN III No 3 30715697 30715697 T C nonsynonymous_SNV TGFBR2:NM_003242:exon5:c.T1355C:p.L452P

TGFBR2 23 CIN III No 3 30715696 30715696 C T synonymous_SNV TGFBR2:NM_003242:exon5:c.C1354T:p.L452L

TP53 23 CIN III No 17 7578403 7578403 C A nonsynonymous_SNV TP53:NM_001126115:exon1:c.G131T:p.C44F

AKAP8 25 CIN IV Yes, at diagnosis 19 15472583 15472583 C T synonymous_SNV AKAP8:NM_005858:exon11:c.G1353A:p.L451L

CACNA1B 25 CIN IV Yes, at diagnosis 9 140918181 140918181 A G nonsynonymous_SNV CACNA1B:NM_000718:exon19:c.A2986G:p.T996A

HCFC1 25 CIN IV Yes, at diagnosis X 153230101 153230101 G A synonymous_SNV HCFC1:NM_005334:exon2:c.C270T:p.D90D

HDAC4 25 CIN IV Yes, at diagnosis 2 240024475 240024475 G T nonsynonymous_SNV HDAC4:NM_006037:exon16:c.C2215A:p.L739I

IRS2 25 CIN IV Yes, at diagnosis 13 110437009 110437009 - G frameshift_insertion IRS2:NM_003749:exon1:c.1392dupC:p.G464fs

KRAS 25 CIN IV Yes, at diagnosis 12 25378562 25378562 C T nonsynonymous_SNV KRAS:NM_004985:exon4:c.G436A:p.A146T

PTPRN2 25 CIN IV Yes, at diagnosis 7 157369389 157369389 G A nonsynonymous_SNV PTPRN2:NM_130842:exon18:c.C2648T:p.T883M

SMARCA4 25 CIN IV Yes, at diagnosis 19 11141493 11141493 G A nonsynonymous_SNV SMARCA4:NM_001128845:exon24:c.G3470A:p.R1157Q

ACTL6B 27 MSI-H III Yes 7 100247724 100247724 T G nonsynonymous_SNV ACTL6B:NM_016188:exon5:c.A404C:p.E135A

ACVR2A 27 MSI-H III Yes 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ACVR2A 27 MSI-H III Yes 2 148676023 148676023 T C nonsynonymous_SNV ACVR2A:NM_001616:exon7:c.T824C:p.L275P AKAP12 27 MSI-H III Yes 6 151672130 151672130 C T synonymous_SNV AKAP12:NM_144497:exon2:c.C2310T:p.S770S

AKAP4 27 MSI-H III Yes X 49962191 49962191 G A splicing mutation AKAP4(NM_003886:exon4:c.174+4C>T

AKAP6 27 MSI-H III Yes 14 33242974 33242974 A G nonsynonymous_SNV AKAP6:NM_004274:exon12:c.A3463G:p.N1155D

AKT1 27 MSI-H III Yes 14 105240252 105240252 G A synonymous_SNV AKT1:NM_001014431:exon8:c.C699T:p.G233G

APC 27 MSI-H III Yes 5 112173704 112173704 C T stopgain_SNV APC:NM_001127511:exon14:c.C2359T:p.R787X

ARID1A 27 MSI-H III Yes 1 27024007 27024007 G - frameshift_deletion ARID1A:NM_006015:exon1:c.1113delG:p.G371fs

ARID1A 27 MSI-H III Yes 1 27088687 27088687 C - frameshift_deletion ARID1A:NM_006015:exon7:c.2296delC:p.Q766fs

ATM 27 MSI-H III Yes 11 108163481 108163481 T C synonymous_SNV ATM:NM_000051:exon30:c.T4572C:p.L1524L

ATP2B4 27 MSI-H III Yes 1 203689717 203689717 T G nonsynonymous_SNV ATP2B4:NM_001001396:exon16:c.T2447G:p.I816S

AXL 27 MSI-H III Yes 19 41726597 41726597 C T nonsynonymous_SNV AXL:NM_001699:exon2:c.C142T:p.R48W

BMPR2 27 MSI-H III Yes 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BRAF 27 MSI-H III Yes 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1G 27 MSI-H III Yes 17 48695289 48695289 A C nonsynonymous_SNV CACNA1G:NM_198376:exon28:c.A5123C:p.Q1708P

CACNG1 27 MSI-H III Yes 17 65050187 65050187 G A splicing mutation CACNG1(NM_000727:exon2:c.304+1G>A)

CACNG5 27 MSI-H III Yes 17 64873580 64873580 - C frameshift_insertion CACNG5:NM_145811:exon1:c.130dupC:p.Q44fs

CAMK2A 27 MSI-H III Yes 5 149602687 149602687 C T nonsynonymous_SNV CAMK2A:NM_171825:exon17:c.G1298A:p.R433H

CBS 27 MSI-H III Yes 21 44480560 44480560 C T nonsynonymous_SNV CBS:NM_000071:exon12:c.G1136A:p.R379Q

CHD7 27 MSI-H III Yes 8 61769445 61769445 G A nonsynonymous_SNV CHD7:NM_017780:exon34:c.G7606A:p.A2536T

CHD7 27 MSI-H III Yes 8 61757434 61757434 G T nonsynonymous_SNV CHD7:NM_017780:exon22:c.G4862T:p.W1621L

CHD7 27 MSI-H III Yes 8 61654711 61654711 G A synonymous_SNV CHD7:NM_017780:exon2:c.G720A:p.Q240Q

CHD9 27 MSI-H III Yes 16 53190798 53190798 A T nonsynonymous_SNV CHD9:NM_025134:exon2:c.A797T:p.N266I

CHD9 27 MSI-H III Yes 16 53340187 53340187 G A nonsynonymous_SNV CHD9:NM_025134:exon32:c.G6658A:p.V2220I

CREBBP 27 MSI-H III Yes 16 3790463 3790463 A - frameshift_deletion CREBBP:NM_001079846:exon23:c.3956delT:p.V1319fs

CTNNA1 27 MSI-H III Yes 5 138160446 138160446 T C synonymous_SNV CTNNA1:NM_001903:exon6:c.T816C:p.G272G

CTNND1 27 MSI-H III Yes 11 57575764 57575764 G A synonymous_SNV CTNND1:NM_001085469:exon9:c.G1770A:p.T590T

DDR2 27 MSI-H III Yes 1 162745495 162745495 T A nonsynonymous_SNV DDR2:NM_006182:exon15:c.T1910A:p.I637N

DNMT3B 27 MSI-H III Yes 20 31368230 31368230 C T nonsynonymous_SNV DNMT3B:NM_001207055:exon2:c.C101T:p.S34L

DOCK3 27 MSI-H III Yes 3 51312594 51312594 G T nonsynonymous_SNV DOCK3:NM_004947:exon25:c.G2633T:p.G878V

DPYS 27 MSI-H III Yes 8 105440218 105440218 T - frameshift_deletion DPYS:NM_001385:exon6:c.1082delA:p.E361fs

ELK1 27 MSI-H III Yes X 47497565 47497565 G C nonsynonymous_SNV ELK1:NM_005229:exon4:c.C671G:p.P224R

EP300 27 MSI-H III Yes 22 41566531 41566531 A - frameshift_deletion EP300:NM_001429:exon27:c.4408delA:p.M1470fs

EP300 27 MSI-H III Yes 22 41564603 41564603 G T nonsynonymous_SNV EP300:NM_001429:exon24:c.G4025T:p.R1342M

EP400 27 MSI-H III Yes 12 132466651 132466651 - C frameshift_insertion EP400:NM_015409:exon5:c.1557dupC:p.P519fs

EPHA10 27 MSI-H III Yes 1 38184059 38184059 C - frameshift_deletion EPHA10:NM_001099439:exon17:c.3012delG:p.Q1004fs EPHA5 27 MSI-H III Yes 4 66356332 66356332 C T nonsynonymous_SNV EPHA5:NM_004439:exon5:c.G1165A:p.V389M

EPHA7 27 MSI-H III Yes 6 94120262 94120262 A G synonymous_SNV EPHA7:NM_004440:exon3:c.T789C:p.C263C

ERBB2 27 MSI-H III Yes 17 37879820 37879820 G A synonymous_SNV ERBB2:NM_004448:exon18:c.G2115A:p.A705A

FBXW7 27 MSI-H III Yes 4 153332590 153332590 A G synonymous_SNV FBXW7:NM_033632:exon2:c.T366C:p.S122S

FHOD3 27 MSI-H III Yes 18 34205521 34205521 C - frameshift_deletion FHOD3:NM_025135:exon10:c.1005delC:p.P335fs

FHOD3 27 MSI-H III Yes 18 34205705 34205705 C T nonsynonymous_SNV FHOD3:NM_025135:exon10:c.C1189T:p.R397C

GART 27 MSI-H III Yes 21 34900550 34900550 T - frameshift_deletion GART:NM_000819:exon10:c.989delA:p.E330fs

GART 27 MSI-H III Yes 21 34900552 34900552 T C synonymous_SNV GART:NM_000819:exon10:c.A987G:p.L329L

GNA11 27 MSI-H III Yes 19 3110269 3110269 A G nonsynonymous_SNV GNA11:NM_002067:exon2:c.A259G:p.M87V

GRIN1 27 MSI-H III Yes 9 140057172 140057172 C T nonsynonymous_SNV GRIN1:NM_000832:exon14:c.C1994T:p.T665M

GUCY1A2 27 MSI-H III Yes 11 106810583 106810583 T G nonsynonymous_SNV GUCY1A2:NM_000855:exon4:c.A809C:p.Q270P

IKBKAP 27 MSI-H III Yes 9 111678530 111678530 C A nonsynonymous_SNV IKBKAP:NM_003640:exon10:c.G912T:p.W304C

JAK1 27 MSI-H III Yes 1 65348985 65348985 C A synonymous_SNV JAK1:NM_002227:exon3:c.G180T:p.L60L

JARID2 27 MSI-H III Yes 6 15496728 15496728 G - frameshift_deletion JARID2:NM_001267040:exon7:c.756delG:p.G252fs

JMJD1C 27 MSI-H III Yes 10 64967746 64967746 - G frameshift_insertion JMJD1C:NM_004241:exon7:c.3026dupC:p.S1009fs

KDM4C 27 MSI-H III Yes 9 7174633 7174633 G A synonymous_SNV KDM4C:NM_015061:exon22:c.G3075A:p.V1025V

KDM8 27 MSI-H III Yes 16 27225038 27225038 G A nonsynonymous_SNV KDM8:NM_001145348:exon3:c.G745A:p.V249M

KDM8 27 MSI-H III Yes 16 27221525 27221525 G A synonymous_SNV KDM8:NM_001145348:exon2:c.G195A:p.P65P

LMTK2 27 MSI-H III Yes 7 97821780 97821780 C T nonsynonymous_SNV LMTK2:NM_014916:exon11:c.C2003T:p.T668I

MAP2K3 27 MSI-H III Yes 17 21203937 21203937 G T synonymous_SNV MAP2K3:NM_002756:exon4:c.G159T:p.R53R

MAP3K10 27 MSI-H III Yes 19 40711828 40711828 G A nonsynonymous_SNV MAP3K10:NM_002446:exon5:c.G1199A:p.S400N

MAPK15 27 MSI-H III Yes 8 144802883 144802883 A G nonsynonymous_SNV MAPK15:NM_139021:exon9:c.A790G:p.T264A

MAPK8IP1 27 MSI-H III Yes 11 45921715 45921715 G A synonymous_SNV MAPK8IP1:NM_005456:exon3:c.G234A:p.A78A

MLH3 27 MSI-H III Yes 14 75514612 75514612 T - frameshift_deletion MLH3:NM_001040108:exon2:c.1747delA:p.K583fs

MLH3 27 MSI-H III Yes 14 75514897 75514897 T - frameshift_deletion MLH3:NM_001040108:exon2:c.1462delA:p.K488fs

MLL2 27 MSI-H III Yes 12 49431879 49431879 C - frameshift_deletion MLL2:NM_003482:exon34:c.9260delG:p.R3087fs

MLL2 27 MSI-H III Yes 12 49426564 49426564 A G nonsynonymous_SNV MLL2:NM_003482:exon39:c.T11924C:p.M3975T

MLL3 27 MSI-H III Yes 7 151874156 151874156 T - frameshift_deletion MLL3:NM_170606:exon38:c.8382delA:p.P2794fs

MLL4 27 MSI-H III Yes 19 36222857 36222857 C A nonsynonymous_SNV MLL4:NM_014727:exon27:c.C5486A:p.P1829H

MLL5 27 MSI-H III Yes 7 104746991 104746991 A - frameshift_deletion MLL5:NM_018682:exon19:c.2619delA:p.K873fs

MLLT1 27 MSI-H III Yes 19 6213982 6213982 - G frameshift_insertion MLLT1:NM_005934:exon9:c.1375dupC:p.P459fs

MMP2 27 MSI-H III Yes 16 55516967 55516967 A G synonymous_SNV MMP2:NM_001127891:exon2:c.A150G:p.P50P

MRE11A 27 MSI-H III Yes 11 94189479 94189479 T - frameshift_deletion MRE11A:NM_005590:exon14:c.1526delA:p.Q509fs

NAV3 27 MSI-H III Yes 12 78388642 78388642 A - frameshift_deletion NAV3:NM_014903:exon6:c.731delA:p.K244fs NFKB2 27 MSI-H III Yes 10 104159946 104159946 C T nonsynonymous_SNV NFKB2:NM_001261403:exon14:c.C1579T:p.H527Y

P2RX3 27 MSI-H III Yes 11 57114063 57114063 C A synonymous_SNV P2RX3:NM_002559:exon2:c.C165A:p.A55A

PAK2 27 MSI-H III Yes 3 196544933 196544933 A G synonymous_SNV PAK2:NM_002577:exon12:c.A1059G:p.L353L

PDGFRA 27 MSI-H III Yes 4 55138643 55138643 G A synonymous_SNV PDGFRA:NM_006206:exon9:c.G1320A:p.T440T

PER1 27 MSI-H III Yes 17 8049771 8049771 A C nonsynonymous_SNV PER1:NM_002616:exon16:c.T1957G:p.S653A

PIAS1 27 MSI-H III Yes 15 68445923 68445923 T C splicing mutation PIAS1(NM_016166:exon7:c.829-5T>C)

PIK3C3 27 MSI-H III Yes 18 39623705 39623705 - T frameshift_insertion PIK3C3:NM_002647:exon20:c.2112dupT:p.F704fs

PLCG2 27 MSI-H III Yes 16 81953123 81953123 C T nonsynonymous_SNV PLCG2:NM_002661:exon20:c.C2089T:p.R697W

PTK2B 27 MSI-H III Yes 8 27288465 27288465 A G nonsynonymous_SNV PTK2B:NM_173175:exon8:c.A742G:p.M248V

PTPN1 27 MSI-H III Yes 20 49195782 49195782 G T synonymous_SNV PTPN1:NM_002827:exon7:c.G780T:p.L260L

PTPRF 27 MSI-H III Yes 1 44044560 44044560 T C synonymous_SNV PTPRF:NM_002840:exon7:c.T648C:p.R216R

PTPRG 27 MSI-H III Yes 3 62189565 62189565 A - frameshift_deletion PTPRG:NM_002841:exon12:c.2096delA:p.K699fs

PTPRG 27 MSI-H III Yes 3 62189512 62189512 A G synonymous_SNV PTPRG:NM_002841:exon12:c.A2043G:p.T681T

PTPRM 27 MSI-H III Yes 18 7949272 7949272 C T stopgain_SNV PTPRM:NM_001105244:exon6:c.C757T:p.R253X

PTPRQ 27 MSI-H III Yes 12 81014042 81014042 A C synonymous_SNV PTPRQ:NM_001145026:exon29:c.A4983C:p.T1661T

RALGDS 27 MSI-H III Yes 9 135983376 135983376 G A nonsynonymous_SNV RALGDS:NM_001042368:exon6:c.C1031T:p.A344V

RASAL1 27 MSI-H III Yes 12 113553809 113553809 C T nonsynonymous_SNV RASAL1:NM_001193521:exon9:c.G779A:p.R260H

RASGRP2 27 MSI-H III Yes 11 64504404 64504404 C T nonsynonymous_SNV RASGRP2:NM_001098670:exon9:c.G916A:p.V306M

RASGRP3 27 MSI-H III Yes 2 33784039 33784039 G A nonsynonymous_SNV RASGRP3:NM_015376:exon16:c.G2003A:p.R668Q

RGS1 27 MSI-H III Yes 1 192545043 192545043 A - frameshift_deletion RGS1:NM_002922:exon1:c.121delA:p.R41fs

RYR1 27 MSI-H III Yes 19 38958400 38958400 C T nonsynonymous_SNV RYR1:NM_000540:exon25:c.C3329T:p.P1110L

RYR1 27 MSI-H III Yes 19 39008115 39008115 C T nonsynonymous_SNV RYR1:NM_000540:exon66:c.C9802T:p.H3268Y

RYR1 27 MSI-H III Yes 19 38964255 38964255 G A nonsynonymous_SNV RYR1:NM_000540:exon28:c.G4004A:p.R1335H

RYR2 27 MSI-H III Yes 1 237947929 237947929 T C nonsynonymous_SNV RYR2:NM_001035:exon90:c.T12917C:p.F4306S

RYR2 27 MSI-H III Yes 1 237969577 237969577 C A synonymous_SNV RYR2:NM_001035:exon99:c.C14292A:p.G4764G

SETD1B 27 MSI-H III Yes 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SHC4 27 MSI-H III Yes 15 49254885 49254885 C A nonsynonymous_SNV SHC4:NM_203349:exon1:c.G328T:p.G110C

SMAD3 27 MSI-H III Yes 15 67473737 67473737 C T synonymous_SNV SMAD3:NM_001145104:exon4:c.C232T:p.L78L

SMARCA4 27 MSI-H III Yes 19 11144081 11144081 A C nonsynonymous_SNV SMARCA4:NM_001128845:exon25:c.A3662C:p.K1221T

SMARCB1 27 MSI-H III Yes 22 24175869 24175869 G A nonsynonymous_SNV SMARCB1:NM_001007468:exon8:c.G1070A:p.R357H

SMARCE1 27 MSI-H III Yes 17 38785191 38785191 G A nonsynonymous_SNV SMARCE1:NM_003079:exon11:c.C1082T:p.T361M

SOS2 27 MSI-H III Yes 14 50626749 50626749 T - frameshift_deletion SOS2:NM_006939:exon10:c.1252delA:p.K418fs

TEK 27 MSI-H III Yes 9 27229174 27229174 C A nonsynonymous_SNV TEK:NM_000459:exon23:c.C3319A:p.L1107I

TGFBR2 27 MSI-H III Yes 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs TP53 27 MSI-H III Yes 17 7579424 7579424 G - frameshift_deletion TP53:NM_001126118:exon3:c.146delC:p.A49fs

TRRAP 27 MSI-H III Yes 7 98522857 98522857 C T synonymous_SNV TRRAP:NM_001244580:exon22:c.C2946T:p.H982H

TYK2 27 MSI-H III Yes 19 10473137 10473137 C T splicing mutation TYK2(NM_003331:exon12:c.1477-5G>A)

ZFYVE16 27 MSI-H III Yes 5 79734727 79734727 G A synonymous_SNV ZFYVE16:NM_014733:exon3:c.G2223A:p.Q741Q

ABL1 29 MSI-H II No 9 133730335 133730335 G A nonsynonymous_SNV ABL1:NM_005157:exon3:c.G401A:p.R134H

ABL2 29 MSI-H II No 1 179076871 179076871 A G synonymous_SNV ABL2:NM_001168236:exon11:c.T3468C:p.S1156S

ACVR2A 29 MSI-H II No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ACVR2B 29 MSI-H II No 3 38523701 38523701 C T nonsynonymous_SNV ACVR2B:NM_001106:exon9:c.C1087T:p.R363W

AKAP12 29 MSI-H II No 6 151670579 151670579 C A synonymous_SNV AKAP12:NM_144497:exon2:c.C759A:p.T253T

APC 29 MSI-H II No 5 112173847 112173847 - GA frameshift_insertion APC:NM_001127511:exon14:c.2502_2503insGA:p.L834fs

ASPH 29 MSI-H II No 8 62438574 62438574 T - frameshift_deletion ASPH:NM_001164750:exon22:c.1775delA:p.E592fs

ATIC 29 MSI-H II No 2 216200799 216200799 C A synonymous_SNV ATIC:NM_004044:exon11:c.C1050A:p.A350A

ATM 29 MSI-H II No 11 108164141 108164141 T - frameshift_deletion ATM:NM_000051:exon31:c.4713delT:p.F1571fs

ATP2A1 29 MSI-H II No 16 28909721 28909721 G A synonymous_SNV ATP2A1:NM_004320:exon14:c.G1713A:p.P571P

BMPR2 29 MSI-H II No 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BMPR2 29 MSI-H II No 2 203332290 203332290 G A nonsynonymous_SNV BMPR2:NM_001204:exon3:c.G296A:p.C99Y

BRAF 29 MSI-H II No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1D 29 MSI-H II No 3 53844198 53844198 G T nonsynonymous_SNV CACNA1D:NM_001128839:exon45:c.G5993T:p.S1998I

CACNA1F 29 MSI-H II No X 49067097 49067097 G - frameshift_deletion CACNA1F:NM_001256789:exon38:c.4438delC:p.P1480fs

CACNA1G 29 MSI-H II No 17 48697049 48697049 G A synonymous_SNV CACNA1G:NM_198379:exon32:c.G5685A:p.R1895R

CACNA2D3 29 MSI-H II No 3 55107855 55107855 G A nonsynonymous_SNV CACNA2D3:NM_018398:exon37:c.G3152A:p.R1051H

CALR 29 MSI-H II No 19 13054702 13054702 C A nonsynonymous_SNV CALR:NM_004343:exon9:c.C1229A:p.P410H

CANX 29 MSI-H II No 5 179149927 179149927 T - frameshift_deletion CANX:NM_001024649:exon11:c.1305delT:p.F435fs

CBLC 29 MSI-H II No 19 45295659 45295659 G T nonsynonymous_SNV CBLC:NM_001130852:exon6:c.G887T:p.W296L

CBS 29 MSI-H II No 21 44486434 44486434 G T nonsynonymous_SNV CBS:NM_000071:exon5:c.C370A:p.L124M

CHD6 29 MSI-H II No 20 40074304 40074304 C A splicing mutation CHD6(NM_032221:exon26:c.3877+1G>T)

CHD6 29 MSI-H II No 20 40044279 40044279 C T splicing mutation CHD6(NM_032221:exon35:c.6487-1G>A)

CTNNA3 29 MSI-H II No 10 67680214 67680214 T - frameshift_deletion CTNNA3:NM_001127384:exon18:c.2562delA:p.A854fs

CTNNBL1 29 MSI-H II No 20 36361422 36361422 A - frameshift_deletion CTNNBL1:NM_030877:exon2:c.172delA:p.R58fs

CTNND1 29 MSI-H II No 11 57575709 57575709 C T nonsynonymous_SNV CTNND1:NM_001085469:exon9:c.C1715T:p.A572V

CTNND2 29 MSI-H II No 5 11346613 11346613 G A nonsynonymous_SNV CTNND2:NM_001332:exon9:c.C1499T:p.A500V

DDR1 29 MSI-H II No 6 30865322 30865322 G A nonsynonymous_SNV DDR1:NM_001202522:exon12:c.G1726A:p.A576T

DNAH3 29 MSI-H II No 16 20975853 20975853 G A nonsynonymous_SNV DNAH3:NM_017539:exon53:c.C9353T:p.A3118V

DNMT1 29 MSI-H II No 19 10260235 10260235 G T nonsynonymous_SNV DNMT1:NM_001379:exon25:c.C2432A:p.P811H EP400 29 MSI-H II No 12 132547094 132547096 CAG - nonframeshift_deletion EP400:NM_015409:exon47:c.8182_8184del:p.2728_2728del

EP400 29 MSI-H II No 12 132562024 132562024 A T nonsynonymous_SNV EP400:NM_015409:exon53:c.A9178T:p.T3060S

EPHA2 29 MSI-H II No 1 16464597 16464597 C - frameshift_deletion EPHA2:NM_004431:exon5:c.1063delG:p.G355fs

EPHA2 29 MSI-H II No 1 16461656 16461656 C T nonsynonymous_SNV EPHA2:NM_004431:exon7:c.G1457A:p.R486H

EPHA8 29 MSI-H II No 1 22927844 22927844 C T synonymous_SNV EPHA8:NM_020526:exon16:c.C2781T:p.S927S

EPHB6 29 MSI-H II No 7 142562052 142562054 CCT - nonframeshift_deletion EPHB6:NM_004445:exon7:c.494_496del:p.165_166del

EZH2 29 MSI-H II No 7 148515030 148515030 C - frameshift_deletion EZH2:NM_152998:exon9:c.1047delG:p.T349fs

FBXW7 29 MSI-H II No 4 153247367 153247367 G A stopgain_SNV FBXW7:NM_001013415:exon9:c.C1081T:p.R361X

FGFR2 29 MSI-H II No 10 123310851 123310851 T - frameshift_deletion FGFR2:NM_001144916:exon2:c.232delA:p.K78fs

FHOD3 29 MSI-H II No 18 34340728 34340728 G A nonsynonymous_SNV FHOD3:NM_025135:exon23:c.G4058A:p.R1353H

FLT1 29 MSI-H II No 13 28877352 28877352 C T synonymous_SNV FLT1:NM_002019:exon30:c.G3969A:p.P1323P

FLT3 29 MSI-H II No 13 28624321 28624321 T - frameshift_deletion FLT3:NM_004119:exon6:c.653delA:p.E218fs

FLT4 29 MSI-H II No 5 180051050 180051050 T C nonsynonymous_SNV FLT4:NM_002020:exon11:c.A1433G:p.Q478R

GNA15 29 MSI-H II No 19 3151763 3151763 G A nonsynonymous_SNV GNA15:NM_002068:exon4:c.G544A:p.V182M

GNAS 29 MSI-H II No 20 57415721 57415721 G T nonsynonymous_SNV GNAS:NM_016592:exon1:c.G560T:p.S187I

GNAS 29 MSI-H II No 20 57480483 57480483 C T nonsynonymous_SNV GNAS:NM_001077489:exon5:c.C433T:p.R145C

GRB2 29 MSI-H II No 17 73316638 73316638 C T splicing mutation GRB2(NM_002086:exon7:c.469-4G>A

GRIN2C 29 MSI-H II No 17 72839532 72839532 C T nonsynonymous_SNV GRIN2C:NM_000835:exon13:c.G2744A:p.R915H

HAT1 29 MSI-H II No 2 172841226 172841226 A G synonymous_SNV HAT1:NM_003642:exon9:c.A954G:p.Q318Q

HDAC4 29 MSI-H II No 2 240002829 240002829 G - frameshift_deletion HDAC4:NM_006037:exon22:c.2697delC:p.D899fs

HDAC4 29 MSI-H II No 2 239988529 239988529 C A nonsynonymous_SNV HDAC4:NM_006037:exon24:c.G2877T:p.Q959H

HDAC5 29 MSI-H II No 17 42169096 42169096 G A nonsynonymous_SNV HDAC5:NM_001015053:exon10:c.C1139T:p.T380M

HDAC5 29 MSI-H II No 17 42165905 42165905 C T synonymous_SNV HDAC5:NM_001015053:exon12:c.G1452A:p.T484T

HDAC6 29 MSI-H II No X 48681329 48681329 A C nonsynonymous_SNV HDAC6:NM_006044:exon25:c.A2520C:p.E840D

HDAC9 29 MSI-H II No 7 18875544 18875544 G T nonsynonymous_SNV HDAC9:NM_058176:exon20:c.G2599T:p.G867W

IKBKAP 29 MSI-H II No 9 111679892 111679892 - A frameshift_insertion IKBKAP:NM_003640:exon9:c.799dupT:p.F267fs

INSRR 29 MSI-H II No 1 156819190 156819190 G A nonsynonymous_SNV INSRR:NM_014215:exon6:c.C1292T:p.A431V

IRS1 29 MSI-H II No 2 227661671 227661671 C - frameshift_deletion IRS1:NM_005544:exon1:c.1784delG:p.R595fs

IRS2 29 MSI-H II No 13 110437311 110437311 C T nonsynonymous_SNV IRS2:NM_003749:exon1:c.G1090A:p.A364T

JAK1 29 MSI-H II No 1 65311304 65311304 A G synonymous_SNV JAK1:NM_002227:exon15:c.T2007C:p.F669F

JAK3 29 MSI-H II No 19 17945771 17945771 G A nonsynonymous_SNV JAK3:NM_000215:exon16:c.C2089T:p.R697W

JUN 29 MSI-H II No 1 59248323 59248323 T G synonymous_SNV JUN:NM_002228:exon1:c.A420C:p.A140A

KAT6A 29 MSI-H II No 8 41789800 41789800 C A nonsynonymous_SNV KAT6A:NM_006766:exon17:c.G5938T:p.G1980C

KDM3A 29 MSI-H II No 2 86707368 86707368 G T nonsynonymous_SNV KDM3A:NM_001146688:exon16:c.G2395T:p.G799C KDM3B 29 MSI-H II No 5 137756577 137756577 G A nonsynonymous_SNV KDM3B:NM_016604:exon15:c.G3898A:p.G1300R

KDM4A 29 MSI-H II No 1 44159683 44159683 T C synonymous_SNV KDM4A:NM_014663:exon17:c.T2394C:p.C798C

KDR 29 MSI-H II No 4 55973991 55973991 G A nonsynonymous_SNV KDR:NM_002253:exon10:c.C1325T:p.T442M

LEPRE1 29 MSI-H II No 1 43232594 43232594 C A nonsynonymous_SNV LEPRE1:NM_001146289:exon1:c.G49T:p.A17S

LEPRE1 29 MSI-H II No 1 43224539 43224539 C T synonymous_SNV LEPRE1:NM_001146289:exon4:c.G924A:p.Q308Q

LEPREL1 29 MSI-H II No 3 189838128 189838128 G A synonymous_SNV LEPREL1:NM_018192:exon1:c.C393T:p.P131P

LMTK2 29 MSI-H II No 7 97823366 97823366 G A nonsynonymous_SNV LMTK2:NM_014916:exon11:c.G3589A:p.E1197K

MAPK4 29 MSI-H II No 18 48190518 48190518 C T stopgain_SNV MAPK4:NM_002747:exon2:c.C190T:p.R64X

MLL2 29 MSI-H II No 12 49443672 49443672 C - frameshift_deletion MLL2:NM_003482:exon11:c.3699delG:p.E1233fs

MLL2 29 MSI-H II No 12 49444982 49444982 A C synonymous_SNV MLL2:NM_003482:exon10:c.T2484G:p.P828P

MLLT1 29 MSI-H II No 19 6222272 6222274 AGG - nonframeshift_deletion MLLT1:NM_005934:exon6:c.968_970del:p.323_324del

MTRR 29 MSI-H II No 5 7870992 7870992 C T nonsynonymous_SNV MTRR:NM_002454:exon2:c.C85T:p.H29Y

NFKB1 29 MSI-H II No 4 103498095 103498095 G A nonsynonymous_SNV NFKB1:NM_001165412:exon7:c.G467A:p.R156Q

PAK6 29 MSI-H II No 15 40558611 40558611 G A nonsynonymous_SNV PAK6:NM_001276717:exon3:c.G773A:p.R258H

PER1 29 MSI-H II No 17 8050608 8050608 C T nonsynonymous_SNV PER1:NM_002616:exon13:c.G1589A:p.S530N

PIAS4 29 MSI-H II No 19 4037613 4037613 G T splicing mutation PIAS4(NM_015897:exon11:c.1274-1G>T)

PLCB2 29 MSI-H II No 15 40581045 40581045 C A nonsynonymous_SNV PLCB2:NM_004573:exon32:c.G3429T:p.R1143S

PTPN5 29 MSI-H II No 11 18754923 18754923 C T splicing mutation PTPN5(NM_032781:exon12:c.1081-4G>A

PTPN7 29 MSI-H II No 1 202128515 202128515 C A nonsynonymous_SNV PTPN7:NM_080588:exon1:c.G133T:p.G45W

PTPRB 29 MSI-H II No 12 70946732 70946732 A C nonsynonymous_SNV PTPRB:NM_001206971:exon18:c.T4288G:p.S1430A

PTPRF 29 MSI-H II No 1 44057496 44057496 C T synonymous_SNV PTPRF:NM_002840:exon10:c.C1545T:p.P515P

PTPRM 29 MSI-H II No 18 8113718 8113718 C A nonsynonymous_SNV PTPRM:NM_001105244:exon12:c.C2091A:p.S697R

PTPRS 29 MSI-H II No 19 5222737 5222737 G - frameshift_deletion PTPRS:NM_130854:exon14:c.3000delC:p.S1000fs

PTPRS 29 MSI-H II No 19 5220135 5220135 G A nonsynonymous_SNV PTPRS:NM_130853:exon14:c.C2287T:p.R763C

PTPRS 29 MSI-H II No 19 5222949 5222949 G A nonsynonymous_SNV PTPRS:NM_130854:exon14:c.C2788T:p.P930S

RELA 29 MSI-H II No 11 65421977 65421977 G - frameshift_deletion RELA:NM_001145138:exon11:c.1519delC:p.P507fs

ROS1 29 MSI-H II No 6 117724358 117724358 G A nonsynonymous_SNV ROS1:NM_002944:exon6:c.C521T:p.A174V

RYK 29 MSI-H II No 3 133914019 133914019 C T unknown UNKNOWN

RYR1 29 MSI-H II No 19 38987086 38987086 G A nonsynonymous_SNV RYR1:NM_000540:exon41:c.G6701A:p.R2234H

RYR3 29 MSI-H II No 15 33952542 33952542 C T nonsynonymous_SNV RYR3:NM_001036:exon34:c.C4540T:p.R1514C

RYR3 29 MSI-H II No 15 34113529 34113529 G A nonsynonymous_SNV RYR3:NM_001243996:exon78:c.G10859A:p.G3620D

SETD1B 29 MSI-H II No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SGPL1 29 MSI-H II No 10 72629626 72629626 T C nonsynonymous_SNV SGPL1:NM_003901:exon9:c.T782C:p.L261S

SOCS2 29 MSI-H II No 12 93968822 93968822 C T nonsynonymous_SNV SOCS2:NM_001270471:exon2:c.C464T:p.P155L STAT5A 29 MSI-H II No 17 40444026 40444026 T C nonsynonymous_SNV STAT5A:NM_003152:exon5:c.T322C:p.C108R

TCF7L2 29 MSI-H II No 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TGFBR2 29 MSI-H II No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

TGFBRAP1 29 MSI-H II No 2 105885902 105885902 C T nonsynonymous_SNV TGFBRAP1:NM_001142621:exon11:c.G2233A:p.A745T

TIE1 29 MSI-H II No 1 43787342 43787342 G T nonsynonymous_SNV TIE1:NM_001253357:exon22:c.G3166T:p.A1056S

TRDN 29 MSI-H II No 6 123786042 123786042 A - frameshift_deletion TRDN:NM_001256020:exon9:c.880delT:p.F294fs

TRPC1 29 MSI-H II No 3 142511768 142511768 T G nonsynonymous_SNV TRPC1:NM_003304:exon8:c.T1438G:p.F480V

TRRAP 29 MSI-H II No 7 98576480 98576480 G A nonsynonymous_SNV TRRAP:NM_003496:exon56:c.G8512A:p.A2838T

TSC1 29 MSI-H II No 9 135772628 135772628 C T nonsynonymous_SNV TSC1:NM_001162427:exon21:c.G2765A:p.G922D

TSC2 29 MSI-H II No 16 2115573 2115573 C A synonymous_SNV TSC2:NM_000548:exon16:c.C1653A:p.A551A

UCKL1 29 MSI-H II No 20 62571996 62571996 C T nonsynonymous_SNV UCKL1:NM_001193379:exon12:c.G1208A:p.R403H

ZAP70 29 MSI-H II No 2 98355924 98355924 C - frameshift_deletion ZAP70:NM_207519:exon6:c.902delC:p.P301fs

ACVR2A 31 MSI-H II No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

AKAP4 31 MSI-H II No X 49958697 49958697 G A stopgain_SNV AKAP4:NM_003886:exon5:c.C667T:p.R223X

ALDH1L1 31 MSI-H II No 3 125877320 125877320 G - frameshift_deletion ALDH1L1:NM_001270364:exon3:c.320delC:p.A107fs

ARID1A 31 MSI-H II No 1 27105937 27105937 G - frameshift_deletion ARID1A:NM_006015:exon20:c.5548delG:p.D1850fs

ARID1B 31 MSI-H II No 6 157099403 157099405 CAG - nonframeshift_deletion ARID1B:NM_017519:exon1:c.340_342del:p.114_114del

ATP2B3 31 MSI-H II No X 152811564 152811564 C T nonsynonymous_SNV ATP2B3:NM_001001344:exon6:c.C935T:p.A312V

ATRX 31 MSI-H II No X 76937014 76937014 G A nonsynonymous_SNV ATRX:NM_138270:exon8:c.C3620T:p.S1207L

BMPR2 31 MSI-H II No 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BMPR2 31 MSI-H II No 2 203395605 203395605 - T frameshift_insertion BMPR2:NM_001204:exon8:c.1056dupT:p.F352fs

BRAF 31 MSI-H II No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1A 31 MSI-H II No 19 13616871 13616871 C A synonymous_SNV CACNA1A:NM_001127221:exon1:c.G168T:p.A56A

CACNA1B 31 MSI-H II No 9 140772555 140772555 C T nonsynonymous_SNV CACNA1B:NM_000718:exon1:c.C170T:p.A57V

CACNA1C 31 MSI-H II No 12 2715820 2715820 C T nonsynonymous_SNV CACNA1C:NM_000719:exon25:c.C3200T:p.A1067V

CACNA1C 31 MSI-H II No 12 2786372 2786372 C T synonymous_SNV CACNA1C:NM_001129837:exon39:c.C4965T:p.N1655N

CACNA1D 31 MSI-H II No 3 53844068 53844068 C T nonsynonymous_SNV CACNA1D:NM_001128839:exon45:c.C5863T:p.R1955W

CACNA1G 31 MSI-H II No 17 48672366 48672366 C T nonsynonymous_SNV CACNA1G:NM_001256324:exon14:c.C2923T:p.R975W

CACNA1I 31 MSI-H II No 22 40058156 40058156 G A nonsynonymous_SNV CACNA1I:NM_001003406:exon16:c.G2983A:p.A995T

CACNA1S 31 MSI-H II No 1 201063052 201063052 C T nonsynonymous_SNV CACNA1S:NM_000069:exon3:c.G356A:p.R119H

CACNA2D1 31 MSI-H II No 7 81746393 81746393 C A nonsynonymous_SNV CACNA2D1:NM_000722:exon6:c.G493T:p.A165S

CACNA2D2 31 MSI-H II No 3 50414899 50414899 G A nonsynonymous_SNV CACNA2D2:NM_001005505:exon17:c.C1625T:p.T542M

CALB1 31 MSI-H II No 8 91090612 91090612 C T nonsynonymous_SNV CALB1:NM_004929:exon3:c.G220A:p.G74R

CAMK2A 31 MSI-H II No 5 149630291 149630291 C T nonsynonymous_SNV CAMK2A:NM_015981:exon10:c.G776A:p.R259H CCNE1 31 MSI-H II No 19 30313453 30313453 C T synonymous_SNV CCNE1:NM_001238:exon11:c.C1053T:p.G351G

CDH20 31 MSI-H II No 18 59170350 59170350 C - frameshift_deletion CDH20:NM_031891:exon4:c.826delC:p.Q276fs

CHD2 31 MSI-H II No 15 93524689 93524689 T C splicing mutation CHD2(NM_001271:exon24:c.3066+2T>C)

CHD5 31 MSI-H II No 1 6196698 6196698 A - frameshift_deletion CHD5:NM_015557:exon17:c.2575delT:p.F859fs

CTNND2 31 MSI-H II No 5 11385045 11385045 C T synonymous_SNV CTNND2:NM_001332:exon7:c.G909A:p.S303S

DVL1 31 MSI-H II No 1 1271832 1271832 C T nonsynonymous_SNV DVL1:NM_004421:exon15:c.G1703A:p.R568Q

EP400 31 MSI-H II No 12 132547094 132547096 CAG - nonframeshift_deletion EP400:NM_015409:exon47:c.8182_8184del:p.2728_2728del

EPHA5 31 MSI-H II No 4 66535320 66535320 G A synonymous_SNV EPHA5:NM_004439:exon1:c.C141T:p.C47C

EPHB3 31 MSI-H II No 3 184290922 184290922 G A nonsynonymous_SNV EPHB3:NM_004443:exon3:c.G814A:p.A272T

FBXW7 31 MSI-H II No 4 153244161 153244161 C - frameshift_deletion FBXW7:NM_001013415:exon11:c.1642delG:p.G548fs

FER 31 MSI-H II No 5 108290528 108290528 - A frameshift_insertion FER:NM_005246:exon12:c.1428dupA:p.K476fs

FGFR2 31 MSI-H II No 10 123274653 123274653 A G nonsynonymous_SNV FGFR2:NM_001144914:exon6:c.T929C:p.I310T

FLT4 31 MSI-H II No 5 180057054 180057054 G A nonsynonymous_SNV FLT4:NM_002020:exon5:c.C565T:p.R189W

GRIN1 31 MSI-H II No 9 140042613 140042613 A - frameshift_deletion GRIN1:NM_001185090:exon4:c.580delA:p.R194fs

GUCY1A2 31 MSI-H II No 11 106810577 106810577 G A nonsynonymous_SNV GUCY1A2:NM_000855:exon4:c.C815T:p.A272V

HCFC1 31 MSI-H II No X 153222107 153222107 G A synonymous_SNV HCFC1:NM_005334:exon15:c.C2604T:p.A868A

IRS1 31 MSI-H II No 2 227660943 227660943 G A stopgain_SNV IRS1:NM_005544:exon1:c.C2512T:p.Q838X

ITPR2 31 MSI-H II No 12 26808663 26808663 - T frameshift_insertion ITPR2:NM_002223:exon20:c.2567dupA:p.E856fs

ITPR3 31 MSI-H II No 6 33651082 33651082 G A nonsynonymous_SNV ITPR3:NM_002224:exon35:c.G4696A:p.A1566T

ITPR3 31 MSI-H II No 6 33626606 33626606 G A splicing mutation ITPR3(NM_002224:exon5:c.528+1G>A)

KDM3B 31 MSI-H II No 5 137727589 137727589 G A synonymous_SNV KDM3B:NM_016604:exon8:c.G2268A:p.Q756Q

MAPK8IP3 31 MSI-H II No 16 1814320 1814320 G A nonsynonymous_SNV MAPK8IP3:NM_001040439:exon18:c.G2119A:p.V707I

MATK 31 MSI-H II No 19 3778213 3778213 C T nonsynonymous_SNV MATK:NM_139354:exon13:c.G1369A:p.G457S

MEN1 31 MSI-H II No 11 64572550 64572550 A G nonsynonymous_SNV MEN1:NM_000244:exon9:c.T1321C:p.W441R

MERTK 31 MSI-H II No 2 112732876 112732876 C T nonsynonymous_SNV MERTK:NM_006343:exon7:c.C971T:p.A324V

MLL2 31 MSI-H II No 12 49420209 49420209 C - frameshift_deletion MLL2:NM_003482:exon48:c.15540delG:p.V5180fs

MLL2 31 MSI-H II No 12 49436620 49436620 - T frameshift_insertion MLL2:NM_003482:exon26:c.5686dupA:p.K1896fs

MLL3 31 MSI-H II No 7 151836312 151836312 G A synonymous_SNV MLL3:NM_170606:exon57:c.C14493T:p.N4831N

MLL4 31 MSI-H II No 19 36223863 36223863 C - frameshift_deletion MLL4:NM_014727:exon28:c.6413delC:p.P2138fs

MLL5 31 MSI-H II No 7 104753439 104753439 G T stopgain_SNV MLL5:NM_018682:exon26:c.G5236T:p.G1746X

MSH6 31 MSI-H II No 2 48030647 48030647 C - frameshift_deletion MSH6:NM_000179:exon5:c.3261delC:p.P1087fs

MTOR 31 MSI-H II No 1 11186807 11186807 C T nonsynonymous_SNV MTOR:NM_004958:exon46:c.G6398A:p.C2133Y

MTRR 31 MSI-H II No 5 7897343 7897343 C T synonymous_SNV MTRR:NM_002454:exon14:c.C1935T:p.G645G

NF1 31 MSI-H II No 17 29422362 29422362 C A nonsynonymous_SNV NF1:NM_000267:exon1:c.C35A:p.A12D NTRK2 31 MSI-H II No 9 87563504 87563504 T - frameshift_deletion NTRK2:NM_001018064:exon17:c.1844delT:p.M615fs

NTRK3 31 MSI-H II No 15 88799180 88799180 C T nonsynonymous_SNV NTRK3:NM_001007156:exon3:c.G205A:p.A69T

P2RX5 31 MSI-H II No 17 3594976 3594976 G A nonsynonymous_SNV P2RX5:NM_001204519:exon2:c.C250T:p.R84W

PAK6 31 MSI-H II No 15 40558465 40558465 C - frameshift_deletion PAK6:NM_001276717:exon3:c.627delC:p.P209fs

PDGFRA 31 MSI-H II No 4 55138646 55138646 G A synonymous_SNV PDGFRA:NM_006206:exon9:c.G1323A:p.P441P

PER1 31 MSI-H II No 17 8048266 8048266 G A nonsynonymous_SNV PER1:NM_002616:exon18:c.C2264T:p.A755V

PIK3C2A 31 MSI-H II No 11 17190955 17190955 T - frameshift_deletion PIK3C2A:NM_002645:exon1:c.334delA:p.K112fs

PIK3CA 31 MSI-H II No 3 178928043 178928043 - A frameshift_insertion PIK3CA:NM_006218:exon8:c.1321dupA:p.M441fs

PIK3R1 31 MSI-H II No 5 67522755 67522755 T C synonymous_SNV PIK3R1:NM_181523:exon2:c.T252C:p.P84P

PIK3R2 31 MSI-H II No 19 18271303 18271303 C T synonymous_SNV PIK3R2:NM_005027:exon3:c.C345T:p.P115P

PMS2 31 MSI-H II No 7 6027164 6027164 T - frameshift_deletion PMS2:NM_000535:exon11:c.1232delA:p.E411fs

PTPN11 31 MSI-H II No 12 112888161 112888161 T C synonymous_SNV PTPN11:NM_002834:exon3:c.T177C:p.T59T

PTPN22 31 MSI-H II No 1 114414181 114414181 T A nonsynonymous_SNV PTPN22:NM_001193431:exon1:c.A65T:p.E22V

PTPRF 31 MSI-H II No 1 44056949 44056949 G A nonsynonymous_SNV PTPRF:NM_002840:exon9:c.G1256A:p.R419H

PTPRS 31 MSI-H II No 19 5212076 5212076 C T nonsynonymous_SNV PTPRS:NM_130853:exon23:c.G3614A:p.G1205D

PTPRS 31 MSI-H II No 19 5231346 5231346 G A synonymous_SNV PTPRS:NM_130854:exon11:c.C2091T:p.P697P

PTPRT 31 MSI-H II No 20 40713419 40713419 G - frameshift_deletion PTPRT:NM_007050:exon29:c.4039delC:p.P1347fs

RASGRF1 31 MSI-H II No 15 79296422 79296422 G A nonsynonymous_SNV RASGRF1:NM_001145648:exon15:c.C2171T:p.P724L

RASGRF1 31 MSI-H II No 15 79339325 79339325 C T nonsynonymous_SNV RASGRF1:NM_001145648:exon5:c.G641A:p.R214Q

RYR2 31 MSI-H II No 1 237947057 237947057 A - frameshift_deletion RYR2:NM_001035:exon90:c.12045delA:p.K4015fs

SETD1A 31 MSI-H II No 16 30976388 30976388 G A nonsynonymous_SNV SETD1A:NM_014712:exon7:c.G1325A:p.G442E

SETD1B 31 MSI-H II No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SLC4A4 31 MSI-H II No 4 72319260 72319260 T - frameshift_deletion SLC4A4:NM_003759:exon9:c.1239delT:p.F413fs

SLC8A1 31 MSI-H II No 2 40656664 40656664 C T nonsynonymous_SNV SLC8A1:NM_001112800:exon1:c.G757A:p.D253N

SLC8A2 31 MSI-H II No 19 47933421 47933421 C T synonymous_SNV SLC8A2:NM_015063:exon10:c.G2691A:p.A897A

SMARCA1 31 MSI-H II No X 128657315 128657315 G A synonymous_SNV SMARCA1:NM_003069:exon1:c.C33T:p.T11T

SMARCA2 31 MSI-H II No 9 2039777 2039779 CAG - nonframeshift_deletion SMARCA2:NM_003070:exon4:c.667_669del:p.223_223del

STAT5A 31 MSI-H II No 17 40459741 40459741 C T nonsynonymous_SNV STAT5A:NM_003152:exon16:c.C1906T:p.P636S

TCF7L2 31 MSI-H II No 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TCF7L2 31 MSI-H II No 10 114911515 114911517 AAG - nonframeshift_deletion TCF7L2:NM_001198530:exon8:c.862_864del:p.288_288del

TGFBR1 31 MSI-H II No 9 101910060 101910060 C T synonymous_SNV TGFBR1:NM_001130916:exon7:c.C1149T:p.S383S

TGFBR2 31 MSI-H II No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

TIE1 31 MSI-H II No 1 43782873 43782873 G A nonsynonymous_SNV TIE1:NM_001253357:exon15:c.G2278A:p.E760K

TNK1 31 MSI-H II No 17 7287467 7287467 C T nonsynonymous_SNV TNK1:NM_001251902:exon6:c.C761T:p.A254V TNK2 31 MSI-H II No 3 195594119 195594119 T C nonsynonymous_SNV TNK2:NM_005781:exon13:c.A2903G:p.H968R

TRRAP 31 MSI-H II No 7 98608763 98608763 C T nonsynonymous_SNV TRRAP:NM_003496:exon69:c.C10898T:p.A3633V

TSC2 31 MSI-H II No 16 2130244 2130244 G A nonsynonymous_SNV TSC2:NM_001077183:exon29:c.G3344A:p.R1115Q

TYK2 31 MSI-H II No 19 10468694 10468694 C T nonsynonymous_SNV TYK2:NM_003331:exon16:c.G2296A:p.A766T

ZFYVE16 31 MSI-H II No 5 79747369 79747369 G A nonsynonymous_SNV ZFYVE16:NM_014733:exon10:c.G3448A:p.G1150R

ACVR2A 33 MSI-H II No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ARID1A 33 MSI-H II No 1 27088687 27088687 C - frameshift_deletion ARID1A:NM_006015:exon7:c.2296delC:p.Q766fs

ATM 33 MSI-H II No 11 108196885 108196885 - A frameshift_insertion ATM:NM_000051:exon47:c.6908dupA:p.K2303fs

ATP2A1 33 MSI-H II No 16 28909720 28909720 C - frameshift_deletion ATP2A1:NM_004320:exon14:c.1712delC:p.P571fs

ATR 33 MSI-H II No 3 142274749 142274749 T - frameshift_deletion ATR:NM_001184:exon10:c.2311delA:p.K771fs

CACNA1A 33 MSI-H II No 19 13319694 13319696 TGG - nonframeshift_deletion CACNA1A:NM_001127221:exon46:c.6657_6659del:p.2219_2220del

CACNA1H 33 MSI-H II No 16 1270502 1270502 C - frameshift_deletion CACNA1H:NM_001005407:exon34:c.6552delC:p.P2184fs

CHD7 33 MSI-H II No 8 61778460 61778460 G - frameshift_deletion CHD7:NM_017780:exon38:c.8962delG:p.D2988fs

CTNNA1 33 MSI-H II No 5 138260958 138260958 T - frameshift_deletion CTNNA1:NM_001903:exon13:c.1761delT:p.F587fs

CTNNA1 33 MSI-H II No 5 138269669 138269672 AGAG - frameshift_deletion CTNNA1:NM_001903:exon18:c.2612_2615del:p.871_872del

CYLD 33 MSI-H II No 16 50783673 50783673 T - frameshift_deletion CYLD:NM_001042355:exon3:c.64delT:p.Y22fs

GRIN1 33 MSI-H II No 9 140042613 140042613 - A frameshift_insertion GRIN1:NM_001185090:exon4:c.580dupA:p.R194fs

KDM5A 33 MSI-H II No 12 416960 416960 T - frameshift_deletion KDM5A:NM_001042603:exon23:c.3590delA:p.Q1197fs

MAP3K1 33 MSI-H II No 5 56178577 56178579 GAA - nonframeshift_deletion MAP3K1:NM_005921:exon14:c.3550_3552del:p.1184_1184del

MAPK15 33 MSI-H II No 8 144804324 144804324 G - frameshift_deletion MAPK15:NM_139021:exon14:c.1538delG:p.G513fs

MLL2 33 MSI-H II No 12 49434944 49434944 C - frameshift_deletion MLL2:NM_003482:exon31:c.6609delG:p.T2203fs

MLL3 33 MSI-H II No 7 151874019 151874019 T - frameshift_deletion MLL3:NM_170606:exon38:c.8519delA:p.E2840fs

NGRN 33 MSI-H II No 15 90809023 90809023 G - frameshift_deletion NGRN:NM_001033088:exon1:c.79delG:p.V27fs

PLCB2 33 MSI-H II No 15 40599846 40599846 G - frameshift_deletion PLCB2:NM_004573:exon1:c.28delC:p.P10fs

PLCE1 33 MSI-H II No 10 96006364 96006364 G A nonsynonymous_SNV PLCE1:NM_001165979:exon7:c.G2158A:p.V720I

RYR1 33 MSI-H II No 19 39025420 39025420 G - frameshift_deletion RYR1:NM_001042723:exon78:c.11305delG:p.A3769fs

SETD1B 33 MSI-H II No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SMAD4 33 MSI-H II No 18 48584519 48584519 G - frameshift_deletion SMAD4:NM_005359:exon6:c.692delG:p.G231fs

SMARCC1 33 MSI-H II No 3 47677565 47677565 - T frameshift_insertion SMARCC1:NM_003074:exon23:c.2438dupA:p.E813fs

SMARCD3 33 MSI-H II No 7 150945596 150945596 A - frameshift_deletion SMARCD3:NM_001003801:exon1:c.53delT:p.L18fs

TNK2 33 MSI-H II No 3 195595236 195595236 G - frameshift_deletion TNK2:NM_005781:exon12:c.1888delC:p.P630fs

TRDN 33 MSI-H II No 6 123673681 123673681 T - frameshift_deletion TRDN:NM_001251987:exon21:c.1375delA:p.K459fs

DNAH3 35 CIN III Yes 16 21063006 21063006 G T nonsynonymous_SNV DNAH3:NM_017539:exon29:c.C4223A:p.T1408N

MST1R 35 CIN III Yes 3 49936326 49936326 G A nonsynonymous_SNV MST1R:NM_001244937:exon3:c.C1522T:p.H508Y PTPRN2 35 CIN III Yes 7 157959688 157959688 G T nonsynonymous_SNV PTPRN2:NM_130842:exon5:c.C794A:p.P265Q

SOCS4 35 CIN III Yes 14 55510604 55510604 A G nonsynonymous_SNV SOCS4:NM_080867:exon2:c.A845G:p.N282S

APC 37 CIN III Yes 5 112170777 112170780 CAGA - frameshift_deletion APC:NM_001127511:exon13:c.1819_1822del:p.607_608del

APC 37 CIN III Yes 5 112175603 112175603 A - frameshift_deletion APC:NM_001127511:exon14:c.4258delA:p.T1420fs

CACNA1I 37 CIN III Yes 22 40082349 40082349 C A nonsynonymous_SNV CACNA1I:NM_001003406:exon36:c.C6506A:p.P2169Q

GNAS 37 CIN III Yes 20 57415838 57415838 G A nonsynonymous_SNV GNAS:NM_016592:exon1:c.G677A:p.R226H

KAT6A 37 CIN III Yes 8 41839436 41839436 G A nonsynonymous_SNV KAT6A:NM_006766:exon4:c.C746T:p.T249M

PIK3CA 37 CIN III Yes 3 178936082 178936082 G A nonsynonymous_SNV p.E542K

PLCB2 37 CIN III Yes 15 40588729 40588729 C T synonymous_SNV PLCB2:NM_004573:exon15:c.G1593A:p.S531S

RASGRF1 37 CIN III Yes 15 79291060 79291060 C A splicing mutation RASGRF1(NM_001145648:exon19:c.2853+1G>T

TSC1 37 CIN III Yes 9 135772115 135772115 G - stopgain_SNV TSC1:NM_001162427:exon22:c.2849delC:p.S950X

APC2 39 CIN IV Yes, at diagnosis 19 1468018 1468018 C A nonsynonymous_SNV APC2:NM_005883:exon15:c.C4718A:p.T1573N

ATP2B3 39 CIN IV Yes, at diagnosis X 152826280 152826280 G A nonsynonymous_SNV ATP2B3:NM_001001344:exon17:c.G2986A:p.V996M

BRAF 39 CIN IV Yes, at diagnosis 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

DNMT1 39 CIN IV Yes, at diagnosis 19 10292749 10292749 - T frameshift_insertion DNMT1:NM_001130823:exon2:c.85dupA:p.K29fs

FNDC1 39 CIN IV Yes, at diagnosis 6 159654963 159654963 G A nonsynonymous_SNV FNDC1:NM_032532:exon11:c.G3419A:p.R1140Q

KAT7 39 CIN IV Yes, at diagnosis 17 47898742 47898742 G A nonsynonymous_SNV KAT7:NM_001199158:exon7:c.G692A:p.R231H

KDM5D 39 CIN IV Yes, at diagnosis Y 21885267 21885267 G T nonsynonymous_SNV KDM5D:NM_001146705:exon12:c.C1424A:p.A475E

MTHFR 39 CIN IV Yes, at diagnosis 1 11856381 11856381 C T nonsynonymous_SNV MTHFR:NM_005957:exon5:c.G662A:p.G221E

NCK1 39 CIN IV Yes, at diagnosis 3 136647031 136647031 G A nonsynonymous_SNV NCK1:NM_006153:exon2:c.G188A:p.R63Q

PAK1 39 CIN IV Yes, at diagnosis 11 77103408 77103408 C T nonsynonymous_SNV PAK1:NM_001128620:exon2:c.G158A:p.R53Q

PIAS2 39 CIN IV Yes, at diagnosis 18 44435553 44435553 C G nonsynonymous_SNV PIAS2:NM_004671:exon4:c.G610C:p.D204H

PIK3CA 39 CIN IV Yes, at diagnosis 3 178936091 178936091 G A nonsynonymous_SNV p.E545K

PLCE1 39 CIN IV Yes, at diagnosis 10 95791191 95791191 G T nonsynonymous_SNV PLCE1:NM_016341:exon2:c.G388T:p.A130S

PLCE1 39 CIN IV Yes, at diagnosis 10 96039631 96039631 G C nonsynonymous_SNV PLCE1:NM_001165979:exon19:c.G3834C:p.E1278D

RTP3 39 CIN IV Yes, at diagnosis 3 46539603 46539603 G T synonymous_SNV RTP3:NM_031440:exon1:c.G51T:p.R17R

SMAD2 39 CIN IV Yes, at diagnosis 18 45368287 45368287 C T nonsynonymous_SNV SMAD2:NM_001135937:exon10:c.G1225A:p.E409K

SMARCA1 39 CIN IV Yes, at diagnosis X 128615123 128615123 G A nonsynonymous_SNV SMARCA1:NM_139035:exon17:c.C2221T:p.R741C

SYNGAP1 39 CIN IV Yes, at diagnosis 6 33393677 33393677 C A nonsynonymous_SNV SYNGAP1:NM_006772:exon3:c.C292A:p.H98N

TP53 39 CIN IV Yes, at diagnosis 17 7576851 7576851 A G splicing mutation TP53(NM_001276761:exon10:c.876+2T>C

APC 41 CIN II No 5 112175426 112175427 GA - frameshift_deletion APC:NM_001127511:exon14:c.4081_4082del:p.1361_1361del

FBXW7 41 CIN II No 4 153244226 153244226 C A nonsynonymous_SNV FBXW7:NM_001013415:exon11:c.G1577T:p.G526V

HGF 41 CIN II No 7 81381528 81381528 C T nonsynonymous_SNV HGF:NM_000601:exon5:c.G533A:p.R178Q

JARID2 41 CIN II No 6 15507458 15507458 C A nonsynonymous_SNV JARID2:NM_001267040:exon10:c.C2117A:p.P706Q MAP3K10 41 CIN II No 19 40719902 40719902 C T synonymous_SNV MAP3K10:NM_002446:exon9:c.C2316T:p.A772A

RYR1 41 CIN II No 19 38985023 38985023 G T synonymous_SNV RYR1:NM_000540:exon39:c.G6306T:p.V2102V

RYR3 41 CIN II No 15 33831549 33831549 A G splicing mutation RYR3(NM_001243996:exon6:c.434-2A>G

TP53 41 CIN II No 17 7578415 7578415 A C nonsynonymous_SNV TP53:NM_001126115:exon1:c.T119G:p.V40G

AKAP9 43 CIN II No 7 91732137 91732137 C T nonsynonymous_SNV AKAP9:NM_005751:exon46:c.C11327T:p.S3776F

APC 43 CIN II No 5 112175168 112175169 AC - frameshift_deletion APC:NM_001127511:exon14:c.3823_3824del:p.1275_1275del

ATM 43 CIN II No 11 108158371 108158371 G T nonsynonymous_SNV ATM:NM_000051:exon27:c.G4038T:p.E1346D

CACNA1D 43 CIN II No 3 53809935 53809935 C T stopgain_SNV CACNA1D:NM_001128839:exon34:c.C4180T:p.Q1394X

CACNG5 43 CIN II No 17 64876727 64876727 A T nonsynonymous_SNV CACNG5:NM_145811:exon3:c.A337T:p.I113F

DNAH3 43 CIN II No 16 20975030 20975030 C A synonymous_SNV DNAH3:NM_017539:exon53:c.G10176T:p.V3392V

FRK 43 CIN II No 6 116277630 116277630 G C nonsynonymous_SNV FRK:NM_002031:exon5:c.C943G:p.Q315E

HRAS 43 CIN II No 11 532669 532669 G A synonymous_SNV HRAS:NM_001130442:exon5:c.C537T:p.P179P

MAPK8IP2 43 CIN II No 22 51042807 51042807 C T unknown UNKNOWN

P2RX5 43 CIN II No 17 3593967 3593967 C G nonsynonymous_SNV P2RX5:NM_001204520:exon3:c.G296C:p.G99A

SMAD4 43 CIN II No 18 48591933 48591933 C G nonsynonymous_SNV SMAD4:NM_005359:exon9:c.C1096G:p.Q366E

SOS1 43 CIN II No 2 39224160 39224160 T G nonsynonymous_SNV SOS1:NM_005633:exon19:c.A2984C:p.N995T

APC 45 CIN IV Yes, at diagnosis 5 112137037 112137038 AA - frameshift_deletion APC:NM_001127511:exon6:c.737_738del:p.246_246del

CHD1 45 CIN IV Yes, at diagnosis 5 98192165 98192167 AGG - nonframeshift_deletion CHD1:NM_001270:exon35:c.5050_5052del:p.1684_1684del

EPHB1 45 CIN IV Yes, at diagnosis 3 134881021 134881021 C T synonymous_SNV EPHB1:NM_004441:exon7:c.C1584T:p.D528D

FGFR3 45 CIN IV Yes, at diagnosis 4 1795760 1795760 G T synonymous_SNV FGFR3:NM_000142:exon2:c.G99T:p.G33G

MAP2K7 45 CIN IV Yes, at diagnosis 19 7975659 7975659 G A nonsynonymous_SNV MAP2K7:NM_145185:exon6:c.G646A:p.E216K

MLL3 45 CIN IV Yes, at diagnosis 7 151871240 151871240 C A nonsynonymous_SNV MLL3:NM_170606:exon39:c.G9350T:p.G3117V

PTPRH 45 CIN IV Yes, at diagnosis 19 55710055 55710055 C G nonsynonymous_SNV PTPRH:NM_001161440:exon6:c.G1112C:p.R371T

TP53 45 CIN IV Yes, at diagnosis 17 7577548 7577548 C T nonsynonymous_SNV TP53:NM_001126115:exon3:c.G337A:p.G113S

AATK 47 CIN IV Yes, at diagnosis 17 79096628 79096628 G A splicing mutation AATK(NM_004920:exon11:c.804-5C>T

AKAP11 47 CIN IV Yes, at diagnosis 13 42875940 42875940 C G nonsynonymous_SNV AKAP11:NM_016248:exon8:c.C3058G:p.L1020V

APC 47 CIN IV Yes, at diagnosis 5 112164614 112164614 - T frameshift_insertion APC:NM_001127511:exon12:c.1634dupT:p.L545fs

APC 47 CIN IV Yes, at diagnosis 5 112175764 112175764 - T frameshift_insertion APC:NM_001127511:exon14:c.4419dupT:p.F1473fs

BRAF 47 CIN IV Yes, at diagnosis 7 140453155 140453155 C T nonsynonymous_SNV BRAF:NM_004333:exon15:c.G1780A:p.D594N

CHD1 47 CIN IV Yes, at diagnosis 5 98192165 98192167 AGG - nonframeshift_deletion CHD1:NM_001270:exon35:c.5050_5052del:p.1684_1684del

CHD5 47 CIN IV Yes, at diagnosis 1 6189072 6189072 C T nonsynonymous_SNV CHD5:NM_015557:exon23:c.G3445A:p.V1149M

CTNNB1 47 CIN IV Yes, at diagnosis 3 41275104 41275104 C G nonsynonymous_SNV CTNNB1:NM_001098209:exon9:c.C1270G:p.L424V

DPP10 47 CIN IV Yes, at diagnosis 2 116525900 116525900 G A nonsynonymous_SNV DPP10:NM_001004360:exon13:c.G1120A:p.G374S

EPHA6 47 CIN IV Yes, at diagnosis 3 96962886 96962886 G T nonsynonymous_SNV EPHA6:NM_001080448:exon5:c.G1361T:p.R454I FGR 47 CIN IV Yes, at diagnosis 1 27941408 27941408 C T nonsynonymous_SNV FGR:NM_001042729:exon10:c.G1048A:p.E350K

KRAS 47 CIN IV Yes, at diagnosis 12 25398282 25398282 C A nonsynonymous_SNV KRAS:NM_004985:exon2:c.G37T:p.G13C

PIK3R5 47 CIN IV Yes, at diagnosis 17 8789829 8789829 C T nonsynonymous_SNV PIK3R5:NM_001251852:exon12:c.G841A:p.A281T

PRKAR2B 47 CIN IV Yes, at diagnosis 7 106685636 106685636 C T nonsynonymous_SNV PRKAR2B:NM_002736:exon1:c.C284T:p.P95L

PTPN13 47 CIN IV Yes, at diagnosis 4 87653895 87653895 T A nonsynonymous_SNV PTPN13:NM_006264:exon12:c.T1834A:p.L612M

PTPRS 47 CIN IV Yes, at diagnosis 19 5244326 5244326 G A nonsynonymous_SNV PTPRS:NM_130853:exon8:c.C1117T:p.R373C

RYR3 47 CIN IV Yes, at diagnosis 15 33822818 33822818 C A nonsynonymous_SNV RYR3:NM_001036:exon4:c.C305A:p.T102N

TP53 47 CIN IV Yes, at diagnosis 17 7578263 7578263 G A stopgain_SNV TP53:NM_001126115:exon2:c.C190T:p.R64X

APC 49 CIN II No 5 112176032 112176032 T - frameshift_deletion APC:NM_001127511:exon14:c.4687delT:p.S1563fs

CACNA1S 49 CIN II No 1 201042768 201042768 C A nonsynonymous_SNV CACNA1S:NM_000069:exon15:c.G2066T:p.G689V

CHD2 49 CIN II No 15 93563463 93563463 C T nonsynonymous_SNV CHD2:NM_001271:exon38:c.C5128T:p.R1710W

HGF 49 CIN II No 7 81334769 81334769 C A nonsynonymous_SNV HGF:NM_000601:exon17:c.G1947T:p.K649N

LCK 49 CIN II No 1 32742015 32742015 G A nonsynonymous_SNV LCK:NM_001042771:exon8:c.G709A:p.E237K

PLCB3 49 CIN II No 11 64026383 64026383 A T nonsynonymous_SNV PLCB3:NM_001184883:exon10:c.A1079T:p.E360V

PTPRF 49 CIN II No 1 44069403 44069403 C T synonymous_SNV PTPRF:NM_130440:exon15:c.C2553T:p.A851A

RYR2 49 CIN II No 1 237947837 237947837 C T synonymous_SNV RYR2:NM_001035:exon90:c.C12825T:p.T4275T

SOS1 49 CIN II No 2 39216455 39216455 C A nonsynonymous_SNV SOS1:NM_005633:exon21:c.G3347T:p.S1116I

TP53 49 CIN II No 17 7578176 7578176 C T splicing mutation TP53(NM_001276761:exon7:c.555+1G>A

ACTL6B 51 CIN II No 7 100253956 100253956 C T nonsynonymous_SNV ACTL6B:NM_016188:exon1:c.G22A:p.G8R

APC 51 CIN II No 5 112175221 112175221 G - frameshift_deletion APC:NM_001127511:exon14:c.3876delG:p.K1292fs

APC 51 CIN II No 5 112175174 112175174 G T stopgain_SNV APC:NM_001127511:exon14:c.G3829T:p.E1277X

CHD9 51 CIN II No 16 53243652 53243652 A C nonsynonymous_SNV CHD9:NM_025134:exon3:c.A1711C:p.K571Q

EPHA7 51 CIN II No 6 93973624 93973624 A C synonymous_SNV EPHA7:NM_004440:exon9:c.T1752G:p.G584G

FNDC1 51 CIN II No 6 159636110 159636110 C T synonymous_SNV FNDC1:NM_032532:exon5:c.C594T:p.Y198Y

HDAC9 51 CIN II No 7 18625069 18625069 T A nonsynonymous_SNV HDAC9:NM_001204147:exon2:c.T95A:p.L32H

ITPR3 51 CIN II No 6 33652593 33652593 G A nonsynonymous_SNV ITPR3:NM_002224:exon39:c.G5180A:p.R1727Q

KDM8 51 CIN II No 16 27221702 27221702 C T synonymous_SNV KDM8:NM_001145348:exon2:c.C372T:p.D124D

KRAS 51 CIN II No 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

PRKAR2B 51 CIN II No 7 106797682 106797682 C T nonsynonymous_SNV PRKAR2B:NM_002736:exon10:c.C1036T:p.R346W

PTPRH 51 CIN II No 19 55697691 55697691 C T nonsynonymous_SNV PTPRH:NM_001161440:exon14:c.G2146A:p.G716S

TP53 51 CIN II No 17 7577539 7577540 GG - frameshift_deletion TP53:NM_001126115:exon3:c.345_346del:p.115_116del

TP53 51 CIN II No 17 7577542 7577542 T - frameshift_deletion TP53:NM_001126115:exon3:c.343delA:p.N115fs

AKAP3 53 CIN III Yes 12 4737038 4737038 C T nonsynonymous_SNV AKAP3:NM_006422:exon4:c.G1030A:p.V344I

APC 53 CIN III Yes 5 112170646 112170646 A G splicing mutation APC(NM_001127511:exon13:c.1690-2A>G GRIN2D 53 CIN III Yes 19 48908245 48908245 C T synonymous_SNV GRIN2D:NM_000836:exon3:c.C720T:p.S240S

HDAC5 53 CIN III Yes 17 42170066 42170066 G A synonymous_SNV HDAC5:NM_001015053:exon7:c.C753T:p.D251D

JMJD1C 53 CIN III Yes 10 64937473 64937473 - A splicing mutation JMJD1C(NM_032776:exon24:c.7224+4->T

MAP3K10 53 CIN III Yes 19 40711894 40711894 G A nonsynonymous_SNV MAP3K10:NM_002446:exon5:c.G1265A:p.R422Q

MAP3K14 53 CIN III Yes 17 43351859 43351859 C A unknown UNKNOWN

MLL2 53 CIN III Yes 12 49432575 49432575 G A nonsynonymous_SNV MLL2:NM_003482:exon34:c.C8564T:p.A2855V

P2RX3 53 CIN III Yes 11 57118367 57118367 C T synonymous_SNV P2RX3:NM_002559:exon8:c.C837T:p.N279N

PAK4 53 CIN III Yes 19 39666007 39666007 G T nonsynonymous_SNV PAK4:NM_001014834:exon5:c.G829T:p.V277L

RET 53 CIN III Yes 10 43622073 43622073 C T synonymous_SNV RET:NM_020630:exon19:c.C3090T:p.D1030D

TP53 53 CIN III Yes 17 7577121 7577121 G A nonsynonymous_SNV TP53:NM_001126115:exon4:c.C421T:p.R141C

AATK 57 CIN III No 17 79094229 79094229 G A synonymous_SNV AATK:NM_004920:exon10:c.C3198T:p.D1066D

ACVR1B 57 CIN III No 12 52374957 52374957 T C nonsynonymous_SNV ACVR1B:NM_004302:exon4:c.T785C:p.L262P

ATP2A2 57 CIN III No 12 110784026 110784026 G A synonymous_SNV ATP2A2:NM_001681:exon20:c.G2880A:p.P960P

ATP2B2 57 CIN III No 3 10387814 10387814 G A synonymous_SNV ATP2B2:NM_001683:exon14:c.C2277T:p.I759I

BRAF 57 CIN III No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1E 57 CIN III No 1 181745334 181745334 G A nonsynonymous_SNV CACNA1E:NM_001205294:exon37:c.G5180A:p.R1727H

CACNA1I 57 CIN III No 22 40082352 40082352 C T nonsynonymous_SNV CACNA1I:NM_001003406:exon36:c.C6509T:p.P2170L

CDH1 57 CIN III No 16 68835592 68835592 C T synonymous_SNV CDH1:NM_004360:exon3:c.C183T:p.T61T

CDH20 57 CIN III No 18 59157988 59157988 G A nonsynonymous_SNV CDH20:NM_031891:exon1:c.G202A:p.V68I

CYP2E1 57 CIN III No 10 135352436 135352436 C T nonsynonymous_SNV CYP2E1:NM_000773:exon9:c.C1450T:p.R484C

FBXW7 57 CIN III No 4 153247289 153247289 G T nonsynonymous_SNV FBXW7:NM_001013415:exon9:c.C1159A:p.R387S

KAT6B 57 CIN III No 10 76781905 76781905 - GAA nonframeshift_insertion KAT6B:NM_001256468:exon16:c.2739_2740insGAA:p.E913delinsEE

KAT6B 57 CIN III No 10 76739073 76739073 C T nonsynonymous_SNV KAT6B:NM_001256468:exon10:c.C1658T:p.S553L

PAK7 57 CIN III No 20 9543630 9543630 G A synonymous_SNV PAK7:NM_177990:exon6:c.C1524T:p.D508D

PER1 57 CIN III No 17 8045244 8045244 C T nonsynonymous_SNV PER1:NM_002616:exon22:c.G3479A:p.R1160Q

PTEN 57 CIN III No 10 89712015 89712015 C G nonsynonymous_SNV PTEN:NM_000314:exon6:c.C633G:p.C211W

PTPN21 57 CIN III No 14 88946316 88946316 C T nonsynonymous_SNV PTPN21:NM_007039:exon13:c.G1459A:p.A487T

PTPN23 57 CIN III No 3 47451011 47451011 C T synonymous_SNV PTPN23:NM_015466:exon18:c.C1902T:p.N634N

PTPRS 57 CIN III No 19 5219993 5219993 C T nonsynonymous_SNV PTPRS:NM_130853:exon14:c.G2429A:p.R810H

RASGRP3 57 CIN III No 2 33752259 33752259 G A nonsynonymous_SNV RASGRP3:NM_015376:exon9:c.G863A:p.R288H

SLC8A1 57 CIN III No 2 40342722 40342722 C T nonsynonymous_SNV SLC8A1:NM_001112801:exon8:c.G2554A:p.A852T

TGFBR1 57 CIN III No 9 101900171 101900171 C T nonsynonymous_SNV TGFBR1:NM_001130916:exon3:c.C374T:p.A125V

APC 59 CIN II Yes 5 112175676 112175679 AGAG - frameshift_deletion APC:NM_001127511:exon14:c.4331_4334del:p.1444_1445del

CACNA1E 59 CIN II Yes 1 181759625 181759625 A G nonsynonymous_SNV CACNA1E:NM_001205294:exon43:c.A5774G:p.Q1925R CACNB3 59 CIN II Yes 12 49221398 49221398 G C nonsynonymous_SNV CACNB3:NM_001206915:exon12:c.G1048C:p.E350Q

KRAS 59 CIN II Yes 12 25380276 25380276 T C nonsynonymous_SNV KRAS:NM_004985:exon3:c.A182G:p.Q61R

MLL4 59 CIN II Yes 19 36214092 36214092 T C nonsynonymous_SNV MLL4:NM_014727:exon6:c.T2918C:p.L973P

MTHFD1 59 CIN II Yes 14 64894167 64894167 C T stopgain_SNV MTHFD1:NM_005956:exon12:c.C1240T:p.Q414X

PAK3 59 CIN II Yes X 110435842 110435842 G C nonsynonymous_SNV PAK3:NM_001128167:exon10:c.G988C:p.D330H

AKAP12 61 CIN II Yes 6 151669998 151669998 G T stopgain_SNV AKAP12:NM_144497:exon2:c.G178T:p.E60X

AKT1 61 CIN II Yes 14 105242094 105242094 G A synonymous_SNV AKT1:NM_001014431:exon5:c.C330T:p.L110L

CHD5 61 CIN II Yes 1 6214813 6214813 C - frameshift_deletion CHD5:NM_015557:exon5:c.652delG:p.E218fs

KRAS 61 CIN II Yes 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

PIK3CG 61 CIN II Yes 7 106515241 106515241 C T nonsynonymous_SNV PIK3CG:NM_002649:exon5:c.C2384T:p.A795V

PTPRJ 61 CIN II Yes 11 48188792 48188792 A G nonsynonymous_SNV PTPRJ:NM_002843:exon25:c.A3892G:p.I1298V

PTPRM 61 CIN II Yes 18 7949268 7949268 C A synonymous_SNV PTPRM:NM_001105244:exon6:c.C753A:p.T251T

PTPRN 61 CIN II Yes 2 220167413 220167413 - C frameshift_insertion PTPRN:NM_001199763:exon5:c.523_524insG:p.P175fs

ROR2 61 CIN II Yes 9 94486921 94486921 G A nonsynonymous_SNV ROR2:NM_004560:exon9:c.C1855T:p.R619C

SLC4A4 61 CIN II Yes 4 72352694 72352694 C A nonsynonymous_SNV SLC4A4:NM_003759:exon12:c.C1801A:p.L601M

TP53 61 CIN II Yes 17 7578239 7578239 C A stopgain_SNV TP53:NM_001126115:exon2:c.G214T:p.E72X

APC 63 CIN III Yes 5 112164616 112164616 C T stopgain_SNV APC:NM_001127511:exon12:c.C1636T:p.R546X

APC 63 CIN III Yes 5 112175390 112175390 C T stopgain_SNV APC:NM_001127511:exon14:c.C4045T:p.Q1349X

ARID1A 63 CIN III Yes 1 27057790 27057790 - T frameshift_insertion ARID1A:NM_006015:exon3:c.1498dupT:p.Y500fs

CACNA2D4 63 CIN III Yes 12 1995135 1995135 C T nonsynonymous_SNV CACNA2D4:NM_172364:exon9:c.G1064A:p.R355Q

CHD5 63 CIN III Yes 1 6214813 6214813 C - frameshift_deletion CHD5:NM_015557:exon5:c.652delG:p.E218fs

CHD9 63 CIN III Yes 16 53269100 53269100 C T nonsynonymous_SNV CHD9:NM_025134:exon11:c.C2515T:p.R839C

CYLD 63 CIN III Yes 16 50813610 50813610 A G nonsynonymous_SNV CYLD:NM_001042355:exon8:c.A1164G:p.I388M

KRAS 63 CIN III Yes 12 25380238 25380238 T G nonsynonymous_SNV KRAS:NM_004985:exon3:c.A220C:p.T74P

PAK7 63 CIN III Yes 20 9561425 9561425 G A synonymous_SNV PAK7:NM_177990:exon4:c.C357T:p.H119H

PTPN6 63 CIN III Yes 12 7070053 7070053 G A synonymous_SNV PTPN6:NM_002831:exon15:c.G1758A:p.E586E

PTPRS 63 CIN III Yes 19 5208389 5208389 C T nonsynonymous_SNV PTPRS:NM_130853:exon27:c.G4160A:p.R1387Q

RPTOR 63 CIN III Yes 17 78831617 78831617 G A nonsynonymous_SNV RPTOR:NM_001163034:exon13:c.G1426A:p.V476M

SLC25A5 63 CIN III Yes X 118603683 118603683 C T synonymous_SNV SLC25A5:NM_001152:exon2:c.C171T:p.C57C

TP53 63 CIN III Yes 17 7577127 7577127 C A stopgain_SNV TP53:NM_001126115:exon4:c.G415T:p.E139X

TYMP 63 CIN III Yes 22 50967943 50967943 C T nonsynonymous_SNV TYMP:NM_001113756:exon1:c.G196A:p.A66T

AATK 65 MSI-H III Yes 17 79101427 79101427 C T nonsynonymous_SNV AATK:NM_004920:exon5:c.G268A:p.A90T

ABL1 65 MSI-H III Yes 9 133730389 133730389 G A nonsynonymous_SNV ABL1:NM_005157:exon3:c.G455A:p.R152H

ABL2 65 MSI-H III Yes 1 179081455 179081455 C T nonsynonymous_SNV ABL2:NM_001136001:exon9:c.G1577A:p.S526N ACVR1B 65 MSI-H III Yes 12 52374839 52374839 C T nonsynonymous_SNV ACVR1B:NM_004302:exon4:c.C667T:p.R223W

ACVR2A 65 MSI-H III Yes 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ACVR2B 65 MSI-H III Yes 3 38519456 38519456 C - frameshift_deletion ACVR2B:NM_001106:exon3:c.365delC:p.P122fs

AKAP12 65 MSI-H III Yes 6 151670351 151670351 A G synonymous_SNV AKAP12:NM_144497:exon2:c.A531G:p.K177K

AKAP14 65 MSI-H III Yes X 119048782 119048782 G A nonsynonymous_SNV AKAP14:NM_178813:exon5:c.G382A:p.V128I

AKAP3 65 MSI-H III Yes 12 4735826 4735826 G - frameshift_deletion AKAP3:NM_006422:exon4:c.2242delC:p.P748fs

AKAP9 65 MSI-H III Yes 7 91603092 91603092 A - frameshift_deletion AKAP9:NM_005751:exon2:c.116delA:p.K39fs

AKT1 65 MSI-H III Yes 14 105238771 105238771 C T synonymous_SNV AKT1:NM_001014431:exon12:c.G1191A:p.E397E

ARID1B 65 MSI-H III Yes 6 157099424 157099425 CA - frameshift_deletion ARID1B:NM_017519:exon1:c.361_362del:p.121_121del

ATIC 65 MSI-H III Yes 2 216177233 216177234 TC - frameshift_deletion ATIC:NM_004044:exon2:c.32_33del:p.11_11del

ATM 65 MSI-H III Yes 11 108216483 108216483 A - frameshift_deletion ATM:NM_000051:exon58:c.8432delA:p.K2811fs

ATP2B4 65 MSI-H III Yes 1 203690381 203690381 T - frameshift_deletion ATP2B4:NM_001001396:exon17:c.2655delT:p.F885fs

ATR 65 MSI-H III Yes 3 142274748 142274749 TT - frameshift_deletion ATR:NM_001184:exon10:c.2311_2312del:p.771_771del

AXIN2 65 MSI-H III Yes 17 63532591 63532591 C - frameshift_deletion AXIN2:NM_004655:exon8:c.1988delG:p.W663fs

BAZ2B 65 MSI-H III Yes 2 160205216 160205216 T C nonsynonymous_SNV BAZ2B:NM_013450:exon30:c.A5266G:p.T1756A

BMPR2 65 MSI-H III Yes 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BMPR2 65 MSI-H III Yes 2 203420207 203420207 A G nonsynonymous_SNV BMPR2:NM_001204:exon12:c.A1819G:p.S607G

BMPR2 65 MSI-H III Yes 2 203383554 203383554 C T stopgain_SNV BMPR2:NM_001204:exon6:c.C631T:p.R211X

BMPR2 65 MSI-H III Yes 2 203383697 203383697 C T synonymous_SNV BMPR2:NM_001204:exon6:c.C774T:p.A258A

CACNA1F 65 MSI-H III Yes X 49066128 49066128 T C synonymous_SNV CACNA1F:NM_001256789:exon41:c.A4782G:p.L1594L

CACNA1G 65 MSI-H III Yes 17 48668825 48668825 G - frameshift_deletion CACNA1G:NM_001256324:exon11:c.2483delG:p.G828fs

CACNA1I 65 MSI-H III Yes 22 40058381 40058381 G A nonsynonymous_SNV CACNA1I:NM_001003406:exon16:c.G3208A:p.V1070I

CACNB2 65 MSI-H III Yes 10 18827217 18827217 C A nonsynonymous_SNV CACNB2:NM_000724:exon12:c.C1246A:p.L416I

CBL 65 MSI-H III Yes 11 119144631 119144631 T C nonsynonymous_SNV CBL:NM_005188:exon4:c.T644C:p.I215T

CHD5 65 MSI-H III Yes 1 6214813 6214813 C - frameshift_deletion CHD5:NM_015557:exon5:c.652delG:p.E218fs

CHD9 65 MSI-H III Yes 16 53263006 53263006 T - frameshift_deletion CHD9:NM_025134:exon8:c.2280delT:p.F760fs

CHD9 65 MSI-H III Yes 16 53276885 53276885 A - frameshift_deletion CHD9:NM_025134:exon13:c.3011delA:p.N1004fs

CREBBP 65 MSI-H III Yes 16 3900707 3900707 G - frameshift_deletion CREBBP:NM_001079846:exon2:c.389delC:p.A130fs

CTNNA1 65 MSI-H III Yes 5 138260403 138260403 C T splicing mutation CTNNA1(NM_001903:exon12:c.1747+4C>T)

DNAH3 65 MSI-H III Yes 16 21139076 21139076 C - frameshift_deletion DNAH3:NM_017539:exon8:c.1140delG:p.L380fs

DNAH3 65 MSI-H III Yes 16 20996655 20996655 C T nonsynonymous_SNV DNAH3:NM_017539:exon48:c.G7409A:p.R2470Q

DNAH3 65 MSI-H III Yes 16 21051238 21051238 C T nonsynonymous_SNV DNAH3:NM_017539:exon33:c.G4666A:p.V1556I

DNAH3 65 MSI-H III Yes 16 21069517 21069517 C T nonsynonymous_SNV DNAH3:NM_017539:exon27:c.G3814A:p.V1272I

DNMT1 65 MSI-H III Yes 19 10254644 10254644 C T nonsynonymous_SNV DNMT1:NM_001379:exon28:c.G2866A:p.V956M DOCK3 65 MSI-H III Yes 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

DOCK3 65 MSI-H III Yes 3 51393580 51393580 G T nonsynonymous_SNV DOCK3:NM_004947:exon42:c.G4310T:p.R1437M

EP400 65 MSI-H III Yes 12 132562043 132562043 A G nonsynonymous_SNV EP400:NM_015409:exon53:c.A9197G:p.Q3066R

EP400 65 MSI-H III Yes 12 132502925 132502925 C A splicing mutation EP400(NM_015409:exon21:c.4277+4C>A)

EP400 65 MSI-H III Yes 12 132547129 132547129 G A synonymous_SNV EP400:NM_015409:exon47:c.G8217A:p.Q2739Q

EPHA5 65 MSI-H III Yes 4 66280018 66280018 A G synonymous_SNV EPHA5:NM_004439:exon7:c.T1671C:p.F557F

ERBB3 65 MSI-H III Yes 12 56495720 56495720 C - frameshift_deletion ERBB3:NM_001982:exon28:c.3910delC:p.H1304fs

ERBB4 65 MSI-H III Yes 2 212285304 212285304 A G synonymous_SNV ERBB4:NM_001042599:exon25:c.T2997C:p.N999N

EXOC4 65 MSI-H III Yes 7 133314896 133314896 T C splicing mutation EXOC4(NM_021807:exon10:c.1514+2T>C)

FGFR2 65 MSI-H III Yes 10 123325146 123325146 C T nonsynonymous_SNV FGFR2:NM_001144913:exon2:c.G182A:p.R61H

FGFR3 65 MSI-H III Yes 4 1808058 1808058 C T splicing mutation FGFR3(NM_000142:exon15:c.2030+4C>T

FNDC1 65 MSI-H III Yes 6 159653873 159653873 G A nonsynonymous_SNV FNDC1:NM_032532:exon11:c.G2329A:p.V777I

GNAL 65 MSI-H III Yes 18 11824949 11824949 C T synonymous_SNV GNAL:NM_182978:exon5:c.C657T:p.D219D

GNAS 65 MSI-H III Yes 20 57415691 57415691 G A nonsynonymous_SNV GNAS:NM_016592:exon1:c.G530A:p.R177H

GUCY1A2 65 MSI-H III Yes 11 106810483 106810483 C A nonsynonymous_SNV GUCY1A2:NM_000855:exon4:c.G909T:p.K303N

HCFC1 65 MSI-H III Yes X 153221807 153221807 C - frameshift_deletion HCFC1:NM_005334:exon16:c.2691delG:p.A897fs

HDAC3 65 MSI-H III Yes 5 141005792 141005792 C T nonsynonymous_SNV HDAC3:NM_003883:exon11:c.G889A:p.G297S

HIF1A 65 MSI-H III Yes 14 62188256 62188256 G T nonsynonymous_SNV HIF1A:NM_001243084:exon3:c.G328T:p.A110S

IGF1R 65 MSI-H III Yes 15 99439990 99439990 T C nonsynonymous_SNV IGF1R:NM_000875:exon4:c.T958C:p.Y320H

ITPR2 65 MSI-H III Yes 12 26749979 26749980 TC - frameshift_deletion ITPR2:NM_002223:exon31:c.4090_4091del:p.1364_1364del

JMJD7-PLA2G4B,PLA2G4B 65 MSI-H III Yes 15 42133437 42133437 G A nonsynonymous_SNV PLA2G4B:NM_001114633:exon6:c.G401A:p.R134H

KAT6A 65 MSI-H III Yes 8 41790022 41790022 T C nonsynonymous_SNV KAT6A:NM_006766:exon17:c.A5716G:p.T1906A

KDM6B 65 MSI-H III Yes 17 7755081 7755081 C A nonsynonymous_SNV KDM6B:NM_001080424:exon17:c.C4132A:p.L1378M

LCK 65 MSI-H III Yes 1 32742235 32742235 C T nonsynonymous_SNV LCK:NM_001042771:exon9:c.C812T:p.A271V

MAPK11 65 MSI-H III Yes 22 50704019 50704019 T C nonsynonymous_SNV MAPK11:NM_002751:exon10:c.A833G:p.N278S

MAPK13 65 MSI-H III Yes 6 36106145 36106145 T C nonsynonymous_SNV MAPK13:NM_002754:exon9:c.T686C:p.L229P

MAPK8 65 MSI-H III Yes 10 49642967 49642967 G A synonymous_SNV MAPK8:NM_139047:exon11:c.G1179A:p.S393S

MAPK8IP3 65 MSI-H III Yes 16 1818554 1818554 G A synonymous_SNV MAPK8IP3:NM_001040439:exon30:c.G3798A:p.S1266S

MAPKBP1 65 MSI-H III Yes 15 42105264 42105264 G T nonsynonymous_SNV MAPKBP1:NM_001128608:exon8:c.G784T:p.D262Y

MLL2 65 MSI-H III Yes 12 49427125 49427125 T G nonsynonymous_SNV MLL2:NM_003482:exon39:c.A11363C:p.Q3788P

MLL2 65 MSI-H III Yes 12 49443783 49443783 T C synonymous_SNV MLL2:NM_003482:exon11:c.A3588G:p.P1196P

MLL3 65 MSI-H III Yes 7 151874156 151874156 T - frameshift_deletion MLL3:NM_170606:exon38:c.8382delA:p.P2794fs

MMP2 65 MSI-H III Yes 16 55516959 55516959 C T nonsynonymous_SNV MMP2:NM_001127891:exon2:c.C142T:p.R48W

MSH6 65 MSI-H III Yes 2 48030647 48030647 C - frameshift_deletion MSH6:NM_000179:exon5:c.3261delC:p.P1087fs MST1R 65 MSI-H III Yes 3 49932730 49932730 G T synonymous_SNV MST1R:NM_001244937:exon13:c.C2994A:p.S998S

MTR 65 MSI-H III Yes 1 237026830 237026830 T C nonsynonymous_SNV MTR:NM_000254:exon22:c.T2381C:p.V794A

NF1 65 MSI-H III Yes 17 29665766 29665766 A G synonymous_SNV NF1:NM_000267:exon45:c.A6801G:p.Q2267Q

NFKBIL1 65 MSI-H III Yes 6 31526276 31526276 G A nonsynonymous_SNV NFKBIL1:NM_001144961:exon4:c.G989A:p.R330H

NTRK1 65 MSI-H III Yes 1 156843579 156843579 G A synonymous_SNV NTRK1:NM_001012331:exon8:c.G1005A:p.P335P

NTRK2 65 MSI-H III Yes 9 87570319 87570319 C A nonsynonymous_SNV NTRK2:NM_001018064:exon18:c.C2011A:p.H671N

P2RX2 65 MSI-H III Yes 12 133196876 133196876 C - frameshift_deletion P2RX2:NM_012226:exon4:c.362delC:p.P121fs

PAK3 65 MSI-H III Yes X 110435362 110435362 G T nonsynonymous_SNV PAK3:NM_001128167:exon9:c.G838T:p.G280C

PAK7 65 MSI-H III Yes 20 9520118 9520118 C T synonymous_SNV PAK7:NM_177990:exon10:c.G2151A:p.R717R

PLCD3 65 MSI-H III Yes 17 43192539 43192539 G T unknown UNKNOWN

PLCG2 65 MSI-H III Yes 16 81944235 81944236 AG - frameshift_deletion PLCG2:NM_002661:exon18:c.1844_1845del:p.615_615del

PMS2 65 MSI-H III Yes 7 6026907 6026907 C T nonsynonymous_SNV PMS2:NM_000535:exon11:c.G1489A:p.G497S

PPP3R2 65 MSI-H III Yes 9 104356964 104356964 G C synonymous_SNV PPP3R2:NM_147180:exon1:c.C249G:p.S83S

PTK2B 65 MSI-H III Yes 8 27303422 27303422 C T nonsynonymous_SNV PTK2B:NM_173176:exon24:c.C2326T:p.R776C

PTK7 65 MSI-H III Yes 6 43098348 43098348 C - frameshift_deletion PTK7:NM_001270398:exon5:c.785delC:p.P262fs

PTK7 65 MSI-H III Yes 6 43098250 43098250 T C synonymous_SNV PTK7:NM_001270398:exon5:c.T687C:p.D229D

PTPN12 65 MSI-H III Yes 7 77229988 77229988 G A nonsynonymous_SNV PTPN12:NM_001131009:exon7:c.G170A:p.R57H

PTPN21 65 MSI-H III Yes 14 88945485 88945485 C T nonsynonymous_SNV PTPN21:NM_007039:exon13:c.G2290A:p.V764I

PTPN3 65 MSI-H III Yes 9 112153778 112153778 T - frameshift_deletion PTPN3:NM_001145372:exon9:c.1021delA:p.K341fs

PTPRD 65 MSI-H III Yes 9 8319965 8319965 C T nonsynonymous_SNV PTPRD:NM_001171025:exon28:c.G4315A:p.A1439T

PTPRF 65 MSI-H III Yes 1 44063699 44063699 G A synonymous_SNV PTPRF:NM_002840:exon12:c.G2094A:p.P698P

PTPRG 65 MSI-H III Yes 3 62257177 62257177 G A synonymous_SNV PTPRG:NM_002841:exon21:c.G3129A:p.R1043R

PTPRK 65 MSI-H III Yes 6 128388781 128388781 A T synonymous_SNV PTPRK:NM_001135648:exon12:c.T2040A:p.P680P

PTPRM 65 MSI-H III Yes 18 7567881 7567881 C T nonsynonymous_SNV PTPRM:NM_001105244:exon1:c.C65T:p.T22M

PTPRQ 65 MSI-H III Yes 12 80982021 80982021 A T nonsynonymous_SNV PTPRQ:NM_001145026:exon23:c.A3883T:p.T1295S

PTPRT 65 MSI-H III Yes 20 40713420 40713420 C T synonymous_SNV PTPRT:NM_007050:exon29:c.G4038A:p.T1346T

RNF111 65 MSI-H III Yes 15 59386984 59386984 G A nonsynonymous_SNV RNF111:NM_001270528:exon14:c.G2873A:p.R958H

ROR2 65 MSI-H III Yes 9 94493297 94493297 C - frameshift_deletion ROR2:NM_004560:exon7:c.1078delG:p.G360fs

RYR2 65 MSI-H III Yes 1 237732451 237732451 C T nonsynonymous_SNV RYR2:NM_001035:exon29:c.C3430T:p.R1144W

RYR2 65 MSI-H III Yes 1 237659835 237659835 C T synonymous_SNV RYR2:NM_001035:exon20:c.C1986T:p.G662G

RYR3 65 MSI-H III Yes 15 34080595 34080595 G A nonsynonymous_SNV RYR3:NM_001036:exon67:c.G9766A:p.A3256T

SETD1A 65 MSI-H III Yes 16 30975501 30975501 C - frameshift_deletion SETD1A:NM_014712:exon6:c.726delC:p.P242fs

SLC24A1 65 MSI-H III Yes 15 65916644 65916646 AGC - nonframeshift_deletion SLC24A1:NM_004727:exon2:c.226_228del:p.76_76del

SLC8A2 65 MSI-H III Yes 19 47935566 47935566 C A nonsynonymous_SNV SLC8A2:NM_015063:exon9:c.G2247T:p.W749C SMARCD2 65 MSI-H III Yes 17 61910964 61910964 C T nonsynonymous_SNV SMARCD2:NM_001098426:exon10:c.G1300A:p.A434T

SND1 65 MSI-H III Yes 7 127361391 127361391 C T synonymous_SNV SND1:NM_014390:exon10:c.C1089T:p.G363G

STAT4 65 MSI-H III Yes 2 191895717 191895717 G T nonsynonymous_SNV STAT4:NM_001243835:exon23:c.C2201A:p.P734H

TCF7L2 65 MSI-H III Yes 10 114910798 114910798 C T nonsynonymous_SNV TCF7L2:NM_001198530:exon7:c.C746T:p.T249M

TGFBR2 65 MSI-H III Yes 3 30691880 30691881 AA - frameshift_deletion TGFBR2:NM_003242:exon3:c.382_383del:p.128_128del

TNK1 65 MSI-H III Yes 17 7286826 7286826 G A nonsynonymous_SNV TNK1:NM_001251902:exon4:c.G317A:p.G106D

TNK2 65 MSI-H III Yes 3 195595236 195595236 - G frameshift_insertion TNK2:NM_005781:exon12:c.1888dupC:p.P630fs

TONSL 65 MSI-H III Yes 8 145665411 145665411 T A synonymous_SNV TONSL:NM_013432:exon11:c.A1473T:p.S491S

TRDN 65 MSI-H III Yes 6 123786042 123786042 A - frameshift_deletion TRDN:NM_001256020:exon9:c.880delT:p.F294fs

ULK1 65 MSI-H III Yes 12 132394342 132394342 G A nonsynonymous_SNV ULK1:NM_003565:exon9:c.G689A:p.R230H

ULK1 65 MSI-H III Yes 12 132395310 132395310 A T nonsynonymous_SNV ULK1:NM_003565:exon12:c.A913T:p.S305C

ACVR2A 67 MSI-H II Yes 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ADAMTSL3 67 MSI-H II Yes 15 84706469 84706469 A G nonsynonymous_SNV ADAMTSL3:NM_207517:exon30:c.A4987G:p.T1663A

AKAP2,PALM2-AKAP2 67 MSI-H II Yes 9 112900489 112900489 C - frameshift_deletion AKAP2:NM_001004065:exon2:c.2239delC:p.Q747fs

ATM 67 MSI-H II Yes 11 108188128 108188128 T C nonsynonymous_SNV ATM:NM_000051:exon43:c.T6227C:p.I2076T

ATRX 67 MSI-H II Yes X 76939457 76939457 C G nonsynonymous_SNV ATRX:NM_138270:exon8:c.G1177C:p.E393Q

AXIN1 67 MSI-H II Yes 16 347797 347797 C T nonsynonymous_SNV AXIN1:NM_003502:exon6:c.G1709A:p.S570N

AXL 67 MSI-H II Yes 19 41765773 41765773 C A synonymous_SNV AXL:NM_001699:exon19:c.C2622A:p.G874G

BMPR2 67 MSI-H II Yes 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BRAF 67 MSI-H II Yes 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1A 67 MSI-H II Yes 19 13321433 13321433 T C nonsynonymous_SNV CACNA1A:NM_001127221:exon44:c.A6340G:p.S2114G

CACNA1B 67 MSI-H II Yes 9 140917727 140917727 C T synonymous_SNV CACNA1B:NM_000718:exon19:c.C2532T:p.G844G

CACNA1E 67 MSI-H II Yes 1 181745335 181745335 C T synonymous_SNV CACNA1E:NM_001205294:exon37:c.C5181T:p.R1727R

CACNA1I 67 MSI-H II Yes 22 40045847 40045847 G A nonsynonymous_SNV CACNA1I:NM_001003406:exon9:c.G1804A:p.V602M

CANX 67 MSI-H II Yes 5 179149927 179149927 T - frameshift_deletion CANX:NM_001024649:exon11:c.1305delT:p.F435fs

CHD1 67 MSI-H II Yes 5 98239544 98239544 C T synonymous_SNV CHD1:NM_001270:exon3:c.G324A:p.Q108Q

CHD5 67 MSI-H II Yes 1 6214813 6214813 C - frameshift_deletion CHD5:NM_015557:exon5:c.652delG:p.E218fs

CHD5 67 MSI-H II Yes 1 6184677 6184677 G A nonsynonymous_SNV CHD5:NM_015557:exon30:c.C4439T:p.A1480V

CHD6 67 MSI-H II Yes 20 40040809 40040809 G A nonsynonymous_SNV CHD6:NM_032221:exon36:c.C7226T:p.A2409V

CREBBP 67 MSI-H II Yes 16 3778167 3778167 C A nonsynonymous_SNV CREBBP:NM_001079846:exon30:c.G6767T:p.R2256L

CRKL 67 MSI-H II Yes 22 21272230 21272230 C T nonsynonymous_SNV CRKL:NM_005207:exon1:c.C8T:p.S3F

CTNND2 67 MSI-H II Yes 5 11346615 11346615 G A synonymous_SNV CTNND2:NM_001332:exon9:c.C1497T:p.Y499Y

DNMT1 67 MSI-H II Yes 19 10254457 10254457 A G nonsynonymous_SNV DNMT1:NM_001379:exon28:c.T3053C:p.V1018A

DPY30 67 MSI-H II Yes 2 32254662 32254662 C G splicing mutation DPY30(NM_032574:exon5:c.227+1G>C) EP300 67 MSI-H II Yes 22 41573645 41573645 G T nonsynonymous_SNV EP300:NM_001429:exon31:c.G5930T:p.S1977I

EP400 67 MSI-H II Yes 12 132561069 132561069 - A frameshift_insertion EP400:NM_015409:exon52:c.9030dupA:p.K3010fs

EP400 67 MSI-H II Yes 12 132547094 132547096 CAG - nonframeshift_deletion EP400:NM_015409:exon47:c.8182_8184del:p.2728_2728del

FLT1 67 MSI-H II Yes 13 29041224 29041227 ACTC - frameshift_deletion FLT1:NM_001159920:exon3:c.201_204del:p.67_68del

GNAS 67 MSI-H II Yes 20 57485397 57485397 G A nonsynonymous_SNV GNAS:NM_001077489:exon11:c.G934A:p.E312K

GRIN2A 67 MSI-H II Yes 16 10274042 10274042 C T nonsynonymous_SNV GRIN2A:NM_001134407:exon2:c.G227A:p.R76H

GRIN2C 67 MSI-H II Yes 17 72846899 72846899 C T nonsynonymous_SNV GRIN2C:NM_000835:exon5:c.G1121A:p.R374H

HCFC1 67 MSI-H II Yes X 153222772 153222772 G A synonymous_SNV HCFC1:NM_005334:exon13:c.C2346T:p.G782G

HCFC2 67 MSI-H II Yes 12 104476542 104476542 - A frameshift_insertion HCFC2:NM_013320:exon7:c.926dupA:p.N309fs

HDAC2 67 MSI-H II Yes 6 114281160 114281161 AT - frameshift_deletion HDAC2:NM_001527:exon2:c.74_75del:p.25_25del

HDAC2 67 MSI-H II Yes 6 114281163 114281163 A - frameshift_deletion HDAC2:NM_001527:exon2:c.72delT:p.Y24fs

INSRR 67 MSI-H II Yes 1 156812996 156812996 G A nonsynonymous_SNV INSRR:NM_014215:exon17:c.C2926T:p.R976W

ITPR1 67 MSI-H II Yes 3 4752015 4752015 G A nonsynonymous_SNV ITPR1:NM_001168272:exon37:c.G4804A:p.V1602I

ITPR2 67 MSI-H II Yes 12 26568298 26568298 A - frameshift_deletion ITPR2:NM_002223:exon51:c.7244delT:p.L2415fs

JAK3 67 MSI-H II Yes 19 17951085 17951085 C T nonsynonymous_SNV JAK3:NM_000215:exon9:c.G1208A:p.R403H

KAT6B 67 MSI-H II Yes 10 76735652 76735652 C T synonymous_SNV KAT6B:NM_012330:exon8:c.C1557T:p.P519P

MAPK8IP1 67 MSI-H II Yes 11 45923942 45923942 T C synonymous_SNV MAPK8IP1:NM_005456:exon5:c.T624C:p.H208H

MLL2 67 MSI-H II Yes 12 49434496 49434496 G - frameshift_deletion MLL2:NM_003482:exon31:c.7057delC:p.P2353fs

MLL2 67 MSI-H II Yes 12 49420661 49420661 G A nonsynonymous_SNV MLL2:NM_003482:exon48:c.C15088T:p.R5030C

MLL3 67 MSI-H II Yes 7 151874156 151874156 T - frameshift_deletion MLL3:NM_170606:exon38:c.8382delA:p.P2794fs

MLL4 67 MSI-H II Yes 19 36224525 36224525 C - frameshift_deletion MLL4:NM_014727:exon29:c.6987delC:p.P2329fs

MLL4 67 MSI-H II Yes 19 36224072 36224072 G T nonsynonymous_SNV MLL4:NM_014727:exon28:c.G6622T:p.G2208C

MLL5 67 MSI-H II Yes 7 104753420 104753420 - A frameshift_insertion MLL5:NM_018682:exon26:c.5217dupA:p.L1739fs

P2RX6 67 MSI-H II Yes 22 21377454 21377455 AC - frameshift_deletion P2RX6:NM_001159554:exon6:c.527_528del:p.176_176del

PIAS4 67 MSI-H II Yes 19 4037823 4037823 C T nonsynonymous_SNV PIAS4:NM_015897:exon11:c.C1483T:p.R495W

PIK3CA 67 MSI-H II Yes 3 178936082 178936082 G A nonsynonymous_SNV p.E542K

PRKACG 67 MSI-H II Yes 9 71628999 71628999 C T nonsynonymous_SNV PRKACG:NM_002732:exon1:c.G10A:p.A4T

PRKDC 67 MSI-H II Yes 8 48771471 48771471 G A unknown UNKNOWN

PTPN2 67 MSI-H II Yes 18 12817207 12817207 G A nonsynonymous_SNV PTPN2:NM_002828:exon6:c.C653T:p.A218V

PTPRK 67 MSI-H II Yes 6 128388831 128388831 - C frameshift_insertion PTPRK:NM_001135648:exon12:c.1990dupG:p.G664fs

PTPRN 67 MSI-H II Yes 2 220167412 220167412 - T frameshift_insertion PTPRN:NM_001199763:exon5:c.524_525insA:p.P175fs

PTPRS 67 MSI-H II Yes 19 5231584 5231584 C T nonsynonymous_SNV PTPRS:NM_130854:exon11:c.G1853A:p.R618H

PTPRZ1 67 MSI-H II Yes 7 121650388 121650388 G - frameshift_deletion PTPRZ1:NM_001206838:exon12:c.1288delG:p.E430fs

PTPRZ1 67 MSI-H II Yes 7 121650385 121650386 AA - splicing mutation PTPRZ1 RASGRP4 67 MSI-H II Yes 19 38909081 38909081 C T nonsynonymous_SNV RASGRP4:NM_001146202:exon7:c.G745A:p.G249R

RPTOR 67 MSI-H II Yes 17 78933974 78933974 G A nonsynonymous_SNV RPTOR:NM_001163034:exon26:c.G3100A:p.V1034I

RYR3 67 MSI-H II Yes 15 34113519 34113519 C T nonsynonymous_SNV RYR3:NM_001243996:exon78:c.C10849T:p.H3617Y

SETD1B 67 MSI-H II Yes 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SHC4 67 MSI-H II Yes 15 49182965 49182965 C A stopgain_SNV SHC4:NM_203349:exon3:c.G700T:p.G234X

SMARCA2 67 MSI-H II Yes 9 2123820 2123820 C T synonymous_SNV SMARCA2:NM_003070:exon27:c.C3864T:p.D1288D

SMARCA4 67 MSI-H II Yes 19 11097095 11097095 C - frameshift_deletion SMARCA4:NM_001128845:exon3:c.586delC:p.L196fs

TGFBR2 67 MSI-H II Yes 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

TIE1 67 MSI-H II Yes 1 43778820 43778820 C - frameshift_deletion TIE1:NM_001253357:exon13:c.1807delC:p.R603fs

TONSL 67 MSI-H II Yes 8 145665411 145665411 T A synonymous_SNV TONSL:NM_013432:exon11:c.A1473T:p.S491S

TONSL 67 MSI-H II Yes 8 145668615 145668615 C T synonymous_SNV TONSL:NM_013432:exon4:c.G354A:p.L118L

TP53 67 MSI-H II Yes 17 7579321 7579322 CA - frameshift_deletion TP53:NM_001126118:exon3:c.248_249del:p.83_83del

TYMS 67 MSI-H II Yes 18 672989 672989 G A nonsynonymous_SNV TYMS:NM_001071:exon7:c.G934A:p.A312T

TYRO3 67 MSI-H II Yes 15 41862345 41862345 C T nonsynonymous_SNV TYRO3:NM_006293:exon10:c.C1373T:p.T458M

WDR5 67 MSI-H II Yes 9 137019604 137019604 C - frameshift_deletion WDR5:NM_052821:exon9:c.648delC:p.P216fs

AKAP13 69 CIN II Yes 15 86125244 86125244 T A synonymous_SNV AKAP13:NM_006738:exon7:c.T3945A:p.P1315P

APC 69 CIN II Yes 5 112174096 112174096 C A stopgain_SNV APC:NM_001127511:exon14:c.C2751A:p.Y917X

APC 69 CIN II Yes 5 112175639 112175639 C T stopgain_SNV APC:NM_001127511:exon14:c.C4294T:p.R1432X

BLK 69 CIN II Yes 8 11418937 11418937 G A nonsynonymous_SNV BLK:NM_001715:exon11:c.G1156A:p.D386N

CACNA1H 69 CIN II Yes 16 1270296 1270296 G T nonsynonymous_SNV CACNA1H:NM_001005407:exon34:c.G6346T:p.A2116S

CHD5 69 CIN II Yes 1 6214813 6214813 C - frameshift_deletion CHD5:NM_015557:exon5:c.652delG:p.E218fs

CHRNA7 69 CIN II Yes 15 32460273 32460273 G A nonsynonymous_SNV CHRNA7:NM_000746:exon10:c.G1123A:p.A375T

GRIN2D 69 CIN II Yes 19 48946480 48946480 G A synonymous_SNV GRIN2D:NM_000836:exon13:c.G3297A:p.A1099A

JARID2 69 CIN II Yes 6 15512615 15512615 C T synonymous_SNV JARID2:NM_001267040:exon14:c.C2613T:p.T871T

MAP2K7 69 CIN II Yes 19 7976183 7976183 C T nonsynonymous_SNV MAP2K7:NM_145185:exon8:c.C904T:p.R302W

NRAS 69 CIN II Yes 1 115258747 115258747 C T nonsynonymous_SNV NRAS:NM_002524:exon2:c.G35A:p.G12D

PLCG2 69 CIN II Yes 16 81888101 81888101 C T synonymous_SNV PLCG2:NM_002661:exon3:c.C246T:p.F82F

PRKDC 69 CIN II Yes 8 48719719 48719719 C T unknown UNKNOWN

PTK2 69 CIN II Yes 8 141874481 141874481 C T nonsynonymous_SNV PTK2:NM_001199649:exon5:c.G380A:p.R127H

PTPN14 69 CIN II Yes 1 214538002 214538002 G C nonsynonymous_SNV PTPN14:NM_005401:exon18:c.C3288G:p.I1096M

PTPRC 69 CIN II Yes 1 198711472 198711472 G C nonsynonymous_SNV PTPRC:NM_080921:exon22:c.G2190C:p.Q730H

PTPRK 69 CIN II Yes 6 128388781 128388781 A T synonymous_SNV PTPRK:NM_001135648:exon12:c.T2040A:p.P680P

PTPRN2 69 CIN II Yes 7 157361600 157361600 C A nonsynonymous_SNV PTPRN2:NM_130842:exon20:c.G2845T:p.A949S

PTPRN2 69 CIN II Yes 7 157361601 157361601 C G nonsynonymous_SNV PTPRN2:NM_130842:exon20:c.G2844C:p.M948I PTPRO 69 CIN II Yes 12 15654589 15654589 G A nonsynonymous_SNV PTPRO:NM_002848:exon5:c.G697A:p.V233I

TONSL 69 CIN II Yes 8 145665411 145665411 T A synonymous_SNV TONSL:NM_013432:exon11:c.A1473T:p.S491S

TP53 69 CIN II Yes 17 7577120 7577120 C T nonsynonymous_SNV TP53:NM_001126115:exon4:c.G422A:p.R141H

ULK1 69 CIN II Yes 12 132401998 132401998 G A nonsynonymous_SNV ULK1:NM_003565:exon22:c.G2225A:p.R742H

APC 71 CIN III Yes 5 112173704 112173704 C T stopgain_SNV APC:NM_001127511:exon14:c.C2359T:p.R787X

CACNA1E 71 CIN III Yes 1 181735699 181735699 C A stopgain_SNV CACNA1E:NM_001205294:exon34:c.C4776A:p.C1592X

GRIN2A 71 CIN III Yes 16 10032289 10032289 A T synonymous_SNV GRIN2A:NM_001134407:exon3:c.T534A:p.P178P

KRAS 71 CIN III Yes 12 25398284 25398284 C G nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35C:p.G12A

PTPRS 71 CIN III Yes 19 5212423 5212423 G A nonsynonymous_SNV PTPRS:NM_130853:exon22:c.C3353T:p.T1118M

TP53 71 CIN III Yes 17 7578437 7578437 G A stopgain_SNV TP53:NM_001126115:exon1:c.C97T:p.Q33X

ZAP70 71 CIN III Yes 2 98341693 98341693 G - frameshift_deletion ZAP70:NM_001079:exon4:c.541delG:p.A181fs

AKAP9 73 CIN III Yes 7 91713993 91713993 C A nonsynonymous_SNV AKAP9:NM_005751:exon34:c.C8686A:p.Q2896K

BRAF 73 CIN III Yes 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1A 73 CIN III Yes 19 13397434 13397434 C T nonsynonymous_SNV CACNA1A:NM_001127221:exon20:c.G3439A:p.V1147I

CACNA1B 73 CIN III Yes 9 141015209 141015209 C T nonsynonymous_SNV CACNA1B:NM_000718:exon45:c.C6365T:p.S2122L

CHD5 73 CIN III Yes 1 6214813 6214813 C - frameshift_deletion CHD5:NM_015557:exon5:c.652delG:p.E218fs

KAT7 73 CIN III Yes 17 47904780 47904780 G C nonsynonymous_SNV KAT7:NM_001199158:exon12:c.G1245C:p.W415C

MATK 73 CIN III Yes 19 3784024 3784024 G A nonsynonymous_SNV MATK:NM_139354:exon5:c.C247T:p.H83Y

MUSK 73 CIN III Yes 9 113538062 113538062 T A splicing mutation MUSK(NM_001166280:exon9:c.949-4T>A

NTRK2 73 CIN III Yes 9 87342855 87342855 C A synonymous_SNV NTRK2:NM_001007097:exon9:c.C1140A:p.G380G

PTK2B 73 CIN III Yes 8 27300391 27300391 G A splicing mutation PTK2B(NM_173174:exon27:c.2040-1G>A

RYR3 73 CIN III Yes 15 33927942 33927942 C T synonymous_SNV RYR3:NM_001036:exon26:c.C3303T:p.V1101V

SETD1A 73 CIN III Yes 16 30991082 30991082 C T synonymous_SNV SETD1A:NM_014712:exon14:c.C3975T:p.A1325A

TP53 73 CIN III Yes 17 7578196 7578196 A C nonsynonymous_SNV TP53:NM_001126115:exon2:c.T257G:p.V86G

ACVR2A 75 MSI-H III No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

AKAP12 75 MSI-H III No 6 151672699 151672699 G A nonsynonymous_SNV AKAP12:NM_144497:exon2:c.G2879A:p.G960D

APC 75 MSI-H III No 5 112175678 112175678 A T stopgain_SNV APC:NM_001127511:exon14:c.A4333T:p.R1445X

ARID1A 75 MSI-H III No 1 27101273 27101273 C - frameshift_deletion ARID1A:NM_006015:exon18:c.4555delC:p.Q1519fs

ARID2 75 MSI-H III No 12 46246593 46246593 A C nonsynonymous_SNV ARID2:NM_152641:exon15:c.A4687C:p.S1563R

ATP2B3 75 MSI-H III No X 152818712 152818712 C T synonymous_SNV ATP2B3:NM_001001344:exon11:c.C2043T:p.D681D

ATP2B4 75 MSI-H III No 1 203681204 203681204 G A synonymous_SNV ATP2B4:NM_001001396:exon13:c.G2148A:p.G716G

CACNA1A 75 MSI-H III No 19 13323263 13323263 T C nonsynonymous_SNV CACNA1A:NM_001127221:exon42:c.A6127G:p.T2043A

CACNA1H 75 MSI-H III No 16 1258193 1258193 A C nonsynonymous_SNV CACNA1H:NM_001005407:exon16:c.A3335C:p.D1112A

CACNA2D4 75 MSI-H III No 12 2027409 2027409 T G splicing mutation CACNA2D4(NM_172364:exon2:c.227+4A>C) CHD6 75 MSI-H III No 20 40050123 40050123 T C nonsynonymous_SNV CHD6:NM_032221:exon31:c.A5152G:p.S1718G

CHD9 75 MSI-H III No 16 53261372 53261372 A - frameshift_deletion CHD9:NM_025134:exon6:c.2108delA:p.K703fs

CHD9 75 MSI-H III No 16 53276758 53276758 A G nonsynonymous_SNV CHD9:NM_025134:exon13:c.A2884G:p.I962V

CREBBP 75 MSI-H III No 16 3823805 3823805 C - frameshift_deletion CREBBP:NM_001079846:exon12:c.2296delG:p.G766fs

CYLD 75 MSI-H III No 16 50783673 50783673 T - frameshift_deletion CYLD:NM_001042355:exon3:c.64delT:p.Y22fs

DDR1 75 MSI-H III No 6 30865247 30865247 C - frameshift_deletion DDR1:NM_001202522:exon12:c.1651delC:p.L551fs

DNMT3A 75 MSI-H III No 2 25469535 25469535 - C frameshift_insertion DNMT3A:NM_153759:exon6:c.666dupG:p.L222fs

ENDOV 75 MSI-H III No 17 78389475 78389475 G A nonsynonymous_SNV ENDOV:NM_001164637:exon2:c.G82A:p.V28I

EP400 75 MSI-H III No 12 132547095 132547096 AG - frameshift_deletion EP400:NM_015409:exon47:c.8183_8184del:p.2728_2728del

EPHB1 75 MSI-H III No 3 134670357 134670357 C T nonsynonymous_SNV EPHB1:NM_004441:exon3:c.C268T:p.R90C

ERBB2 75 MSI-H III No 17 37873699 37873699 G A nonsynonymous_SNV ERBB2:NM_004448:exon15:c.G1864A:p.A622T

FHOD3 75 MSI-H III No 18 33877956 33877956 C A nonsynonymous_SNV FHOD3:NM_025135:exon1:c.C158A:p.P53Q

FLT1 75 MSI-H III No 13 28942768 28942768 A G nonsynonymous_SNV FLT1:NM_001160030:exon15:c.T2149C:p.S717P

FLT4 75 MSI-H III No 5 180057561 180057561 C T nonsynonymous_SNV FLT4:NM_002020:exon3:c.G394A:p.V132M

GRIN2A 75 MSI-H III No 16 9857521 9857521 T C nonsynonymous_SNV GRIN2A:NM_001134407:exon13:c.A3880G:p.N1294D

HDAC5 75 MSI-H III No 17 42157535 42157535 C T nonsynonymous_SNV HDAC5:NM_001015053:exon23:c.G2887A:p.G963R

HDAC6 75 MSI-H III No X 48673091 48673091 C T nonsynonymous_SNV HDAC6:NM_006044:exon12:c.C943T:p.R315W

HDAC8 75 MSI-H III No X 71715033 71715033 C T nonsynonymous_SNV HDAC8:NM_001166418:exon3:c.G250A:p.V84M

KDM5D 75 MSI-H III No Y 21867929 21867929 A G synonymous_SNV KDM5D:NM_001146706:exon26:c.T4401C:p.S1467S

KDM8 75 MSI-H III No 16 27221630 27221630 C T synonymous_SNV KDM8:NM_001145348:exon2:c.C300T:p.D100D

KDR 75 MSI-H III No 4 55991433 55991433 C T nonsynonymous_SNV KDR:NM_002253:exon1:c.G28A:p.A10T

KIT 75 MSI-H III No 4 55594085 55594085 T C nonsynonymous_SNV KIT:NM_000222:exon12:c.T1871C:p.M624T

KRAS 75 MSI-H III No 12 25398281 25398281 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G38A:p.G13D

LMTK2 75 MSI-H III No 7 97823472 97823472 C T nonsynonymous_SNV LMTK2:NM_014916:exon11:c.C3695T:p.T1232M

LTK 75 MSI-H III No 15 41804093 41804093 A G synonymous_SNV LTK:NM_001135685:exon5:c.T579C:p.D193D

MAPK13 75 MSI-H III No 6 36099110 36099110 A G nonsynonymous_SNV MAPK13:NM_002754:exon2:c.A182G:p.Q61R

MAPK14 75 MSI-H III No 6 35995942 35995942 A G nonsynonymous_SNV MAPK14:NM_001315:exon1:c.A8G:p.Q3R

MAPK8IP1 75 MSI-H III No 11 45926556 45926556 A - frameshift_deletion MAPK8IP1:NM_005456:exon10:c.1928delA:p.N643fs

MLL2 75 MSI-H III No 12 49445996 49445996 C A nonsynonymous_SNV MLL2:NM_003482:exon10:c.G1470T:p.E490D

MLL2 75 MSI-H III No 12 49427679 49427679 C T synonymous_SNV MLL2:NM_003482:exon39:c.G10809A:p.Q3603Q

MLL2 75 MSI-H III No 12 49427268 49427268 C T synonymous_SNV MLL2:NM_003482:exon39:c.G11220A:p.Q3740Q

MLL3 75 MSI-H III No 7 151874156 151874156 T - frameshift_deletion MLL3:NM_170606:exon38:c.8382delA:p.P2794fs

MLST8 75 MSI-H III No 16 2258242 2258242 G - frameshift_deletion MLST8:NM_001199173:exon7:c.605delG:p.G202fs

MSH2 75 MSI-H III No 2 47630393 47630393 C A synonymous_SNV MSH2:NM_000251:exon1:c.C63A:p.R21R MST1R 75 MSI-H III No 3 49934248 49934248 C - frameshift_deletion MST1R:NM_001244937:exon8:c.2259delG:p.V753fs

P2RX7 75 MSI-H III No 12 121603935 121603935 G A nonsynonymous_SNV P2RX7:NM_002562:exon7:c.G689A:p.R230Q

PAK6 75 MSI-H III No 15 40566452 40566452 C - frameshift_deletion PAK6:NM_001276717:exon8:c.1853delC:p.P618fs

PIK3C2B 75 MSI-H III No 1 204403675 204403675 A C nonsynonymous_SNV PIK3C2B:NM_002646:exon25:c.T3578G:p.I1193S

PLCD1 75 MSI-H III No 3 38049996 38049996 C T nonsynonymous_SNV PLCD1:NM_001130964:exon12:c.G1918A:p.A640T

PTK7 75 MSI-H III No 6 43098055 43098055 G A synonymous_SNV PTK7:NM_001270398:exon4:c.G582A:p.T194T

PTPN14 75 MSI-H III No 1 214557223 214557223 T G nonsynonymous_SNV PTPN14:NM_005401:exon13:c.A1975C:p.K659Q

PTPRG 75 MSI-H III No 3 62257212 62257212 C - frameshift_deletion PTPRG:NM_002841:exon21:c.3164delC:p.P1055fs

PTPRS 75 MSI-H III No 19 5231578 5231578 G A nonsynonymous_SNV PTPRS:NM_130854:exon11:c.C1859T:p.T620M

RAP1GDS1 75 MSI-H III No 4 99342450 99342450 C T nonsynonymous_SNV RAP1GDS1:NM_001100430:exon10:c.C1072T:p.R358C

RBBP5 75 MSI-H III No 1 205065955 205065955 G - frameshift_deletion RBBP5:NM_001193272:exon12:c.1251delC:p.G417fs

RYR2 75 MSI-H III No 1 237969502 237969502 T - frameshift_deletion RYR2:NM_001035:exon99:c.14217delT:p.F4739fs

SETD1A 75 MSI-H III No 16 30977038 30977038 G T synonymous_SNV SETD1A:NM_014712:exon8:c.G1836T:p.P612P

SETD1B 75 MSI-H III No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SLC24A1 75 MSI-H III No 15 65918213 65918213 A G nonsynonymous_SNV SLC24A1:NM_004727:exon2:c.A1795G:p.T599A

SND1 75 MSI-H III No 7 127724856 127724856 C - frameshift_deletion SND1:NM_014390:exon19:c.2191delC:p.R731fs

SND1 75 MSI-H III No 7 127341377 127341377 G T nonsynonymous_SNV SND1:NM_014390:exon5:c.G589T:p.A197S

TGFBR2 75 MSI-H III No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

TNK1 75 MSI-H III No 17 7287476 7287476 G A nonsynonymous_SNV TNK1:NM_001251902:exon6:c.G770A:p.R257H

TONSL 75 MSI-H III No 8 145661198 145661198 C T nonsynonymous_SNV TONSL:NM_013432:exon17:c.G2618A:p.R873H

TONSL 75 MSI-H III No 8 145662159 145662159 A G nonsynonymous_SNV TONSL:NM_013432:exon15:c.T1871C:p.V624A

TRAF2 75 MSI-H III No 9 139814921 139814921 G A nonsynonymous_SNV TRAF2:NM_021138:exon8:c.G914A:p.R305Q

TRDN 75 MSI-H III No 6 123673681 123673681 T - frameshift_deletion TRDN:NM_001251987:exon21:c.1375delA:p.K459fs

AKAP3 77 CIN III No 12 4736612 4736612 G A nonsynonymous_SNV AKAP3:NM_006422:exon4:c.C1456T:p.R486C

AKT1 77 CIN III No 14 105238771 105238771 C T synonymous_SNV AKT1:NM_001014431:exon12:c.G1191A:p.E397E

APC 77 CIN III No 5 112175255 112175255 G T stopgain_SNV APC:NM_001127511:exon14:c.G3910T:p.E1304X

APC 77 CIN III No 5 112173704 112173704 C T stopgain_SNV APC:NM_001127511:exon14:c.C2359T:p.R787X

CHD5 77 CIN III No 1 6214813 6214813 C - frameshift_deletion CHD5:NM_015557:exon5:c.652delG:p.E218fs

CSF1R 77 CIN III No 5 149452864 149452864 C T nonsynonymous_SNV CSF1R:NM_005211:exon7:c.G1082A:p.R361K

DNAH3 77 CIN III No 16 21063186 21063186 C T nonsynonymous_SNV DNAH3:NM_017539:exon29:c.G4043A:p.R1348H

GUCY1A2 77 CIN III No 11 106579284 106579284 A G nonsynonymous_SNV GUCY1A2:NM_000855:exon7:c.T1945C:p.S649P

MAPK8IP2 77 CIN III No 22 51042514 51042514 C T unknown UNKNOWN

RAB5A 77 CIN III No 3 20017242 20017242 G C nonsynonymous_SNV RAB5A:NM_004162:exon3:c.G313C:p.E105Q

SOS1 77 CIN III No 2 39283913 39283913 T A nonsynonymous_SNV SOS1:NM_005633:exon4:c.A440T:p.N147I TP53 77 CIN III No 17 7577142 7577142 C G nonsynonymous_SNV TP53:NM_001126115:exon4:c.G400C:p.G134R

TYRO3 77 CIN III No 15 41865285 41865285 G A nonsynonymous_SNV TYRO3:NM_006293:exon16:c.G1961A:p.R654Q

AATK 79 MSI-H III No 17 79102321 79102321 G A synonymous_SNV AATK:NM_004920:exon3:c.C54T:p.G18G

ACVR2A 79 MSI-H III No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

AKAP11 79 MSI-H III No 13 42875091 42875091 A G nonsynonymous_SNV AKAP11:NM_016248:exon8:c.A2209G:p.T737A

AKAP2,PALM2-AKAP2 79 MSI-H III No 9 112899383 112899383 A G nonsynonymous_SNV AKAP2:NM_001004065:exon2:c.A1133G:p.Q378R

AKAP2,PALM2-AKAP2 79 MSI-H III No 9 112900549 112900549 G A nonsynonymous_SNV AKAP2:NM_001004065:exon2:c.G2299A:p.G767R

AKT2 79 MSI-H III No 19 40741903 40741903 G A nonsynonymous_SNV AKT2:NM_001243028:exon10:c.C883T:p.R295C

ATM 79 MSI-H III No 11 108114823 108114823 T - frameshift_deletion ATM:NM_000051:exon6:c.640delT:p.S214fs

ATP2A3 79 MSI-H III No 17 3832677 3832677 G A nonsynonymous_SNV ATP2A3:NM_005173:exon19:c.C2807T:p.A936V

ATRX 79 MSI-H III No X 76888772 76888772 T C nonsynonymous_SNV ATRX:NM_138270:exon18:c.A4943G:p.Y1648C

BMPR2 79 MSI-H III No 2 203378462 203378462 C T stopgain_SNV BMPR2:NM_001204:exon4:c.C439T:p.R147X

BRAF 79 MSI-H III No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1A 79 MSI-H III No 19 13319694 13319696 TGG - nonframeshift_deletion CACNA1A:NM_001127221:exon46:c.6657_6659del:p.2219_2220del

CACNA1E 79 MSI-H III No 1 181680102 181680103 AG - frameshift_deletion CACNA1E:NM_000721:exon8:c.1068_1069del:p.356_357del

CACNA1F 79 MSI-H III No X 49087371 49087371 G - frameshift_deletion CACNA1F:NM_001256789:exon4:c.462delC:p.H154fs

CACNA1G 79 MSI-H III No 17 48650140 48650140 A G synonymous_SNV CACNA1G:NM_001256324:exon6:c.A972G:p.S324S

CACNA2D3 79 MSI-H III No 3 54537574 54537574 T - frameshift_deletion CACNA2D3:NM_018398:exon5:c.437delT:p.L146fs

CANX 79 MSI-H III No 5 179149926 179149927 TT - frameshift_deletion CANX:NM_001024649:exon11:c.1304_1305del:p.435_435del

CBLC 79 MSI-H III No 19 45285637 45285637 C T nonsynonymous_SNV CBLC:NM_001130852:exon4:c.C668T:p.T223I

CDKN2A 79 MSI-H III No 9 21971173 21971173 A G nonsynonymous_SNV CDKN2A:NM_000077:exon2:c.T185C:p.L62P

CHD4 79 MSI-H III No 12 6711145 6711146 TC - frameshift_deletion CHD4:NM_001273:exon4:c.418_419del:p.140_140del

CHD5 79 MSI-H III No 1 6214813 6214813 C - frameshift_deletion CHD5:NM_015557:exon5:c.652delG:p.E218fs

CHD5 79 MSI-H III No 1 6169960 6169960 G T nonsynonymous_SNV CHD5:NM_015557:exon38:c.C5473A:p.L1825I

DAXX 79 MSI-H III No 6 33289246 33289246 C T synonymous_SNV DAXX:NM_001254717:exon2:c.G81A:p.S27S

DPF2 79 MSI-H III No 11 65113831 65113831 G A splicing mutation DPF2(NM_006268:exon9:c.1017+1G>A)

DVL2 79 MSI-H III No 17 7130487 7130487 G A stopgain_SNV DVL2:NM_004422:exon13:c.C1465T:p.R489X

DVL3 79 MSI-H III No 3 183885377 183885377 A G nonsynonymous_SNV DVL3:NM_004423:exon12:c.A1208G:p.D403G

EID2 79 MSI-H III No 19 40030202 40030202 T C nonsynonymous_SNV EID2:NM_153232:exon1:c.A518G:p.E173G

EID3 79 MSI-H III No 12 104697740 104697740 G A nonsynonymous_SNV EID3:NM_001008394:exon1:c.G28A:p.A10T

ENDOV 79 MSI-H III No 17 78399363 78399363 C T synonymous_SNV ENDOV:NM_001164637:exon6:c.C522T:p.A174A

EP400 79 MSI-H III No 12 132547094 132547096 CAG - nonframeshift_deletion EP400:NM_015409:exon47:c.8182_8184del:p.2728_2728del

EPHA3 79 MSI-H III No 3 89391168 89391168 G A nonsynonymous_SNV EPHA3:NM_005233:exon5:c.G1234A:p.V412I

EXOC4 79 MSI-H III No 7 133164807 133164807 C T synonymous_SNV EXOC4:NM_001037126:exon9:c.C1332T:p.F444F FBXW7 79 MSI-H III No 4 153247367 153247367 G A stopgain_SNV FBXW7:NM_001013415:exon9:c.C1081T:p.R361X

FHOD3 79 MSI-H III No 18 34205521 34205521 C - frameshift_deletion FHOD3:NM_025135:exon10:c.1005delC:p.P335fs

FNDC1 79 MSI-H III No 6 159636039 159636039 G A nonsynonymous_SNV FNDC1:NM_032532:exon5:c.G523A:p.V175I

GART 79 MSI-H III No 21 34911524 34911524 - G frameshift_insertion GART:NM_000819:exon2:c.98dupC:p.A33fs

IKBKB 79 MSI-H III No 8 42178335 42178335 G A nonsynonymous_SNV IKBKB:NM_001190720:exon15:c.G1655A:p.R552Q

ITPR1 79 MSI-H III No 3 4683918 4683918 C T stopgain_SNV ITPR1:NM_001099952:exon7:c.C508T:p.R170X

ITPR3 79 MSI-H III No 6 33632657 33632657 G A nonsynonymous_SNV ITPR3:NM_002224:exon12:c.G1159A:p.V387I

JARID2 79 MSI-H III No 6 15520352 15520352 A - frameshift_deletion JARID2:NM_001267040:exon18:c.3095delA:p.N1032fs

JARID2 79 MSI-H III No 6 15496432 15496432 C T nonsynonymous_SNV JARID2:NM_001267040:exon7:c.C460T:p.R154C

JMJD4 79 MSI-H III No 1 227920644 227920644 C T nonsynonymous_SNV JMJD4:NM_001161465:exon5:c.G1045A:p.A349T

KAT6A 79 MSI-H III No 8 41798849 41798849 G A synonymous_SNV KAT6A:NM_006766:exon15:c.C2550T:p.V850V

KAT6A 79 MSI-H III No 8 41790737 41790737 T C synonymous_SNV KAT6A:NM_006766:exon17:c.A5001G:p.Q1667Q

KAT6B 79 MSI-H III No 10 76788961 76788961 T - stopgain_SNV KAT6B:NM_001256468:exon18:c.3830delT:p.L1277X

KAT8 79 MSI-H III No 16 31142516 31142516 T C nonsynonymous_SNV KAT8:NM_032188:exon11:c.T1313C:p.V438A

KDM3A 79 MSI-H III No 2 86709739 86709739 T C synonymous_SNV KDM3A:NM_001146688:exon18:c.T2844C:p.D948D

KDM4B 79 MSI-H III No 19 5071022 5071022 T C nonsynonymous_SNV KDM4B:NM_015015:exon7:c.T628C:p.Y210H

KDM5A 79 MSI-H III No 12 402031 402031 T C nonsynonymous_SNV KDM5A:NM_001042603:exon27:c.A4760G:p.K1587R

KDM5C 79 MSI-H III No X 53223788 53223789 CA - frameshift_deletion KDM5C:NM_001146702:exon21:c.3369_3370del:p.1123_1124del

KDM6B 79 MSI-H III No 17 7752526 7752526 C T nonsynonymous_SNV KDM6B:NM_001080424:exon11:c.C2920T:p.R974W

KIT 79 MSI-H III No 4 55561757 55561757 C T synonymous_SNV KIT:NM_000222:exon2:c.C147T:p.R49R

MAP2K7 79 MSI-H III No 19 7974719 7974719 C - frameshift_deletion MAP2K7:NM_145185:exon2:c.204delC:p.P68fs

MAP3K1 79 MSI-H III No 5 56170982 56170982 G T stopgain_SNV MAP3K1:NM_005921:exon10:c.G1810T:p.G604X

MAPK8IP2 79 MSI-H III No 22 51044103 51044103 G A unknown UNKNOWN

MAPK8IP3 79 MSI-H III No 16 1798347 1798347 G T nonsynonymous_SNV MAPK8IP3:NM_001040439:exon7:c.G1094T:p.S365I

MLL 79 MSI-H III No 11 118374218 118374218 A T nonsynonymous_SNV MLL:NM_001197104:exon27:c.A7611T:p.Q2537H

MLL2 79 MSI-H III No 12 49434496 49434496 G - frameshift_deletion MLL2:NM_003482:exon31:c.7057delC:p.P2353fs

MLL2 79 MSI-H III No 12 49434567 49434567 - G frameshift_insertion MLL2:NM_003482:exon31:c.6986dupC:p.A2329fs

MLL2 79 MSI-H III No 12 49448497 49448497 C T nonsynonymous_SNV MLL2:NM_003482:exon3:c.G214A:p.G72R

MLL3 79 MSI-H III No 7 151874156 151874156 T - frameshift_deletion MLL3:NM_170606:exon38:c.8382delA:p.P2794fs

MLL4 79 MSI-H III No 19 36224001 36224001 C A nonsynonymous_SNV MLL4:NM_014727:exon28:c.C6551A:p.P2184H

MLL4 79 MSI-H III No 19 36218053 36218053 C A splicing mutation MLL4(NM_014727:exon15:c.4004-4C>A)

MTOR 79 MSI-H III No 1 11288915 11288915 T C nonsynonymous_SNV MTOR:NM_004958:exon19:c.A2840G:p.Y947C

NFKB1 79 MSI-H III No 4 103500048 103500048 - A frameshift_insertion NFKB1:NM_001165412:exon8:c.579dupA:p.K193fs

NTRK2 79 MSI-H III No 9 87635158 87635158 C T nonsynonymous_SNV NTRK2:NM_001018064:exon19:c.C2162T:p.P721L PAK2 79 MSI-H III No 3 196541373 196541373 G - frameshift_deletion PAK2:NM_002577:exon11:c.987delG:p.G329fs

PDGFRB 79 MSI-H III No 5 149495443 149495443 G A synonymous_SNV PDGFRB:NM_002609:exon23:c.C3204T:p.D1068D

PIK3C2A 79 MSI-H III No 11 17190955 17190955 T - frameshift_deletion PIK3C2A:NM_002645:exon1:c.334delA:p.K112fs

PIK3C2A 79 MSI-H III No 11 17121463 17121463 A G synonymous_SNV PIK3C2A:NM_002645:exon25:c.T4062C:p.V1354V

PIK3C3 79 MSI-H III No 18 39623705 39623705 T - frameshift_deletion PIK3C3:NM_002647:exon20:c.2112delT:p.F704fs

PIK3CB 79 MSI-H III No 3 138413666 138413666 G A synonymous_SNV PIK3CB:NM_001256045:exon3:c.C390T:p.Y130Y

PIK3CG 79 MSI-H III No 7 106508374 106508374 G A nonsynonymous_SNV PIK3CG:NM_002649:exon2:c.G368A:p.R123H

PLCB1 79 MSI-H III No 20 8770844 8770844 G A nonsynonymous_SNV PLCB1:NM_015192:exon31:c.G3359A:p.R1120Q

PLCB1 79 MSI-H III No 20 8703023 8703023 C T synonymous_SNV PLCB1:NM_015192:exon15:c.C1536T:p.D512D

PLCB2 79 MSI-H III No 15 40585893 40585893 G A synonymous_SNV PLCB2:NM_004573:exon20:c.C2094T:p.S698S

PRKAR1A 79 MSI-H III No 17 66511559 66511559 G A nonsynonymous_SNV PRKAR1A:NM_001276290:exon1:c.G19A:p.A7T

PTPN21 79 MSI-H III No 14 88946027 88946027 C T nonsynonymous_SNV PTPN21:NM_007039:exon13:c.G1748A:p.R583H

PTPN23 79 MSI-H III No 3 47451558 47451558 G A nonsynonymous_SNV PTPN23:NM_015466:exon20:c.G2270A:p.R757Q

PTPN3 79 MSI-H III No 9 112185134 112185134 T C splicing mutation PTPN3(NM_001145369:exon9:c.609-2A>G

PTPRA 79 MSI-H III No 20 2968737 2968737 G A nonsynonymous_SNV PTPRA:NM_080840:exon7:c.G560A:p.R187H

PTPRF 79 MSI-H III No 1 44071945 44071945 A G nonsynonymous_SNV PTPRF:NM_130440:exon19:c.A3491G:p.Q1164R

PTPRM 79 MSI-H III No 18 8085782 8085782 G A synonymous_SNV PTPRM:NM_001105244:exon10:c.G1665A:p.P555P

RASGRP4 79 MSI-H III No 19 38909075 38909075 G T nonsynonymous_SNV RASGRP4:NM_001146202:exon7:c.C751A:p.L251I

REL 79 MSI-H III No 2 61149652 61149652 T C synonymous_SNV REL:NM_002908:exon11:c.T1842C:p.Y614Y

RET 79 MSI-H III No 10 43612143 43612143 G T nonsynonymous_SNV RET:NM_020630:exon12:c.G2248T:p.A750S

RGS2 79 MSI-H III No 1 192779375 192779375 A - frameshift_deletion RGS2:NM_002923:exon2:c.190delA:p.S64fs

RPS6KB1 79 MSI-H III No 17 58011597 58011597 C T nonsynonymous_SNV RPS6KB1:NM_001272042:exon7:c.C686T:p.T229I

RYR1 79 MSI-H III No 19 39062771 39062771 C T nonsynonymous_SNV RYR1:NM_001042723:exon94:c.C13844T:p.A4615V

RYR1 79 MSI-H III No 19 38976770 38976770 C T synonymous_SNV RYR1:NM_000540:exon34:c.C5475T:p.H1825H

SETD1B 79 MSI-H III No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SMAD9 79 MSI-H III No 13 37453599 37453599 G A synonymous_SNV SMAD9:NM_001127217:exon2:c.C228T:p.D76D

SMARCA2 79 MSI-H III No 9 2039785 2039785 G A synonymous_SNV SMARCA2:NM_003070:exon4:c.G675A:p.Q225Q

SMARCA4 79 MSI-H III No 19 11097088 11097088 G - frameshift_deletion SMARCA4:NM_001128845:exon3:c.579delG:p.G193fs

SMARCA4 79 MSI-H III No 19 11132434 11132434 C T nonsynonymous_SNV SMARCA4:NM_001128845:exon18:c.C2650T:p.H884Y

SMARCC1 79 MSI-H III No 3 47823213 47823213 G T synonymous_SNV SMARCC1:NM_003074:exon1:c.C75A:p.A25A

SMARCC2 79 MSI-H III No 12 56578858 56578858 G T nonsynonymous_SNV SMARCC2:NM_001130420:exon4:c.C355A:p.R119S

SRC 79 MSI-H III No 20 36031153 36031153 T C synonymous_SNV SRC:NM_005417:exon13:c.T1272C:p.G424G

STAT3 79 MSI-H III No 17 40468884 40468884 G - frameshift_deletion STAT3:NM_003150:exon23:c.2177delC:p.S726fs

TGFBR2 79 MSI-H III No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs TNK2 79 MSI-H III No 3 195595236 195595236 - G frameshift_insertion TNK2:NM_005781:exon12:c.1888dupC:p.P630fs

TNK2 79 MSI-H III No 3 195595354 195595354 C T synonymous_SNV TNK2:NM_005781:exon12:c.G1770A:p.A590A

TSC2 79 MSI-H III No 16 2122885 2122885 C T synonymous_SNV TSC2:NM_000548:exon21:c.C2256T:p.G752G

UMPS 79 MSI-H III No 3 124449376 124449376 G A nonsynonymous_SNV UMPS:NM_000373:exon1:c.G58A:p.A20T

WDR5 79 MSI-H III No 9 137019604 137019604 C - frameshift_deletion WDR5:NM_052821:exon9:c.648delC:p.P216fs

AKAP12 81 CIN III No 6 151670345 151670345 A T nonsynonymous_SNV AKAP12:NM_144497:exon2:c.A525T:p.Q175H

AKAP6 81 CIN III No 14 33290650 33290650 G T nonsynonymous_SNV AKAP6:NM_004274:exon13:c.G3631T:p.G1211W

APC 81 CIN III No 5 112162945 112162945 G A splicing mutation APC(NM_001127511:exon10:c.1494+1G>A

CALM1 81 CIN III No 14 90870268 90870268 G A nonsynonymous_SNV CALM1:NM_006888:exon4:c.G241A:p.D81N

CHD5 81 CIN III No 1 6214813 6214813 C - frameshift_deletion CHD5:NM_015557:exon5:c.652delG:p.E218fs

EP400 81 CIN III No 12 132512031 132512031 C T synonymous_SNV EP400:NM_015409:exon26:c.C5064T:p.P1688P

KDR 81 CIN III No 4 55976673 55976673 C T synonymous_SNV KDR:NM_002253:exon9:c.G1152A:p.T384T

PRKDC 81 CIN III No 8 48749960 48749960 C - unknown UNKNOWN

PTPRN2 81 CIN III No 7 158109547 158109547 G A nonsynonymous_SNV PTPRN2:NM_130842:exon2:c.C190T:p.R64C

RNF111 81 CIN III No 15 59376431 59376431 C T stopgain_SNV RNF111:NM_001270528:exon9:c.C2428T:p.Q810X

RYR2 81 CIN III No 1 237947912 237947912 C T synonymous_SNV RYR2:NM_001035:exon90:c.C12900T:p.S4300S

SMARCA2 81 CIN III No 9 2161775 2161775 A C synonymous_SNV SMARCA2:NM_003070:exon28:c.A4071C:p.A1357A

TP53 81 CIN III No 17 7578394 7578394 T A nonsynonymous_SNV TP53:NM_001126115:exon1:c.A140T:p.H47L

AATK 83 MSI-H II Yes 17 79093239 79093239 G A nonsynonymous_SNV AATK:NM_004920:exon12:c.C3716T:p.A1239V

ACTB 83 MSI-H II Yes 7 5569016 5569016 T C nonsynonymous_SNV ACTB:NM_001101:exon3:c.A139G:p.M47V

ACVR2A 83 MSI-H II Yes 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ACVR2B 83 MSI-H II Yes 3 38521293 38521293 G A nonsynonymous_SNV ACVR2B:NM_001106:exon7:c.G935A:p.G312D

AKAP11 83 MSI-H II Yes 13 42876624 42876624 C A nonsynonymous_SNV AKAP11:NM_016248:exon8:c.C3742A:p.P1248T

AKAP11 83 MSI-H II Yes 13 42874615 42874615 A T nonsynonymous_SNV AKAP11:NM_016248:exon8:c.A1733T:p.N578I

AKAP11 83 MSI-H II Yes 13 42875212 42875212 T C nonsynonymous_SNV AKAP11:NM_016248:exon8:c.T2330C:p.V777A

AKAP13 83 MSI-H II Yes 15 86278860 86278860 A - frameshift_deletion AKAP13:NM_001270546:exon24:c.3374delA:p.K1125fs

ALK 83 MSI-H II Yes 2 29416783 29416783 C T synonymous_SNV ALK:NM_004304:exon29:c.G4170A:p.P1390P

APC2 83 MSI-H II Yes 19 1470165 1470165 G A nonsynonymous_SNV APC2:NM_005883:exon15:c.G6865A:p.A2289T

ARID1B 83 MSI-H II Yes 6 157505386 157505386 C T nonsynonymous_SNV ARID1B:NM_017519:exon12:c.C3328T:p.R1110C

ASH2L 83 MSI-H II Yes 8 37991013 37991013 A - frameshift_deletion ASH2L:NM_001105214:exon13:c.1287delA:p.K429fs

ATP2A3 83 MSI-H II Yes 17 3851141 3851141 A G synonymous_SNV ATP2A3:NM_005173:exon8:c.T639C:p.N213N

ATP2B3 83 MSI-H II Yes X 152823661 152823661 G - frameshift_deletion ATP2B3:NM_001001344:exon15:c.2525delG:p.G842fs

ATRX 83 MSI-H II Yes X 76931744 76931744 A G synonymous_SNV ATRX:NM_138270:exon9:c.T3672C:p.D1224D

BMPR2 83 MSI-H II Yes 2 203420006 203420006 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1618delA:p.I540fs BRAF 83 MSI-H II Yes 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1F 83 MSI-H II Yes X 49070657 49070657 T C nonsynonymous_SNV CACNA1F:NM_001256789:exon30:c.A3670G:p.I1224V

CACNA1G 83 MSI-H II Yes 17 48678108 48678108 G A nonsynonymous_SNV CACNA1G:NM_001256332:exon17:c.G3643A:p.A1215T

CACNA1I 83 MSI-H II Yes 22 40060106 40060106 T A nonsynonymous_SNV CACNA1I:NM_001003406:exon19:c.T3503A:p.F1168Y

CACNA1I 83 MSI-H II Yes 22 40055039 40055039 C T nonsynonymous_SNV CACNA1I:NM_001003406:exon11:c.C2143T:p.R715C

CACNB2 83 MSI-H II Yes 10 18787346 18787346 T C synonymous_SNV CACNB2:NM_000724:exon3:c.T231C:p.D77D

CACNG2 83 MSI-H II Yes 22 36960573 36960573 G A nonsynonymous_SNV CACNG2:NM_006078:exon4:c.C797T:p.T266M

CBLC 83 MSI-H II Yes 19 45297508 45297508 C - frameshift_deletion CBLC:NM_001130852:exon8:c.1194delC:p.P398fs

CDKN2A 83 MSI-H II Yes 9 21994278 21994278 G A nonsynonymous_SNV CDKN2A:NM_058195:exon1:c.C53T:p.P18L

CHD1 83 MSI-H II Yes 5 98236703 98236704 TC - frameshift_deletion CHD1:NM_001270:exon6:c.670_671del:p.224_224del

CHD1 83 MSI-H II Yes 5 98236706 98236706 T - frameshift_deletion CHD1:NM_001270:exon6:c.668delA:p.E223fs

CHD3 83 MSI-H II Yes 17 7810752 7810752 G - frameshift_deletion CHD3:NM_001005271:exon32:c.5047delG:p.V1683fs

CHD3 83 MSI-H II Yes 17 7810536 7810536 A G nonsynonymous_SNV CHD3:NM_001005271:exon31:c.A4936G:p.S1646G

CHD4 83 MSI-H II Yes 12 6690974 6690974 C G nonsynonymous_SNV CHD4:NM_001273:exon31:c.G4522C:p.E1508Q

CHD6 83 MSI-H II Yes 20 40033729 40033729 G A nonsynonymous_SNV CHD6:NM_032221:exon37:c.C7652T:p.P2551L

CHD8 83 MSI-H II Yes 14 21862213 21862213 T C nonsynonymous_SNV CHD8:NM_001170629:exon31:c.A5741G:p.Q1914R

CHD8 83 MSI-H II Yes 14 21899053 21899053 G A synonymous_SNV CHD8:NM_001170629:exon1:c.C750T:p.L250L

CTNNB1 83 MSI-H II Yes 3 41267067 41267067 A G splicing mutation CTNNB1(NM_001098209:exon5:c.734+4A>G

DNAH3 83 MSI-H II Yes 16 21136542 21136542 A G nonsynonymous_SNV DNAH3:NM_017539:exon9:c.T1358C:p.V453A

DNMT3A 83 MSI-H II Yes 2 25467447 25467447 G A synonymous_SNV DNMT3A:NM_153759:exon10:c.C1062T:p.G354G

DNMT3B 83 MSI-H II Yes 20 31374366 31374366 G A nonsynonymous_SNV DNMT3B:NM_006892:exon5:c.G365A:p.R122H

DOCK3 83 MSI-H II Yes 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

DRD3 83 MSI-H II Yes 3 113890677 113890677 G A synonymous_SNV DRD3:NM_000796:exon2:c.C163T:p.L55L

EP400 83 MSI-H II Yes 12 132547094 132547096 CAG - nonframeshift_deletion EP400:NM_015409:exon47:c.8182_8184del:p.2728_2728del

EP400 83 MSI-H II Yes 12 132466653 132466653 C T nonsynonymous_SNV EP400:NM_015409:exon5:c.C1559T:p.T520M

EPHA10 83 MSI-H II Yes 1 38227636 38227636 G A synonymous_SNV EPHA10:NM_001099439:exon3:c.C291T:p.R97R

EPHA5 83 MSI-H II Yes 4 66270109 66270109 G A synonymous_SNV EPHA5:NM_004439:exon8:c.C1773T:p.G591G

EPHB6 83 MSI-H II Yes 7 142563321 142563321 C T synonymous_SNV EPHB6:NM_004445:exon8:c.C1038T:p.P346P

FHOD3 83 MSI-H II Yes 18 34205521 34205521 C - frameshift_deletion FHOD3:NM_025135:exon10:c.1005delC:p.P335fs

FLT4 83 MSI-H II Yes 5 180038454 180038454 G A nonsynonymous_SNV FLT4:NM_002020:exon27:c.C3563T:p.P1188L

FNDC1 83 MSI-H II Yes 6 159653499 159653499 G A nonsynonymous_SNV FNDC1:NM_032532:exon11:c.G1955A:p.R652H

GART 83 MSI-H II Yes 21 34892747 34892747 T C synonymous_SNV GART:NM_000819:exon14:c.A1626G:p.K542K

GNAS 83 MSI-H II Yes 20 57430116 57430116 G A nonsynonymous_SNV GNAS:NM_001077490:exon1:c.G1609A:p.A537T

GRB2 83 MSI-H II Yes 17 73316484 73316484 G A nonsynonymous_SNV GRB2:NM_203506:exon5:c.C496T:p.R166C GRIN2C 83 MSI-H II Yes 17 72848357 72848357 G - frameshift_deletion GRIN2C:NM_000835:exon3:c.793delC:p.P265fs

GRIN2D 83 MSI-H II Yes 19 48947025 48947025 C T nonsynonymous_SNV GRIN2D:NM_000836:exon13:c.C3842T:p.A1281V

GRIN2D 83 MSI-H II Yes 19 48908036 48908036 C T stopgain_SNV GRIN2D:NM_000836:exon3:c.C511T:p.Q171X

HCFC2 83 MSI-H II Yes 12 104476542 104476542 A - frameshift_deletion HCFC2:NM_013320:exon7:c.926delA:p.N309fs

HDAC4 83 MSI-H II Yes 2 240033249 240033249 G - frameshift_deletion HDAC4:NM_006037:exon14:c.1936delC:p.P646fs

HDAC4 83 MSI-H II Yes 2 240056119 240056119 G A synonymous_SNV HDAC4:NM_006037:exon11:c.C1116T:p.D372D

HDAC5 83 MSI-H II Yes 17 42163946 42163946 T C nonsynonymous_SNV HDAC5:NM_001015053:exon14:c.A2047G:p.T683A

HDAC5 83 MSI-H II Yes 17 42165926 42165926 A T synonymous_SNV HDAC5:NM_001015053:exon12:c.T1431A:p.R477R

IRS1 83 MSI-H II Yes 2 227663001 227663001 C T nonsynonymous_SNV IRS1:NM_005544:exon1:c.G454A:p.G152S

ITPR2 83 MSI-H II Yes 12 26648185 26648185 - T frameshift_insertion ITPR2:NM_002223:exon38:c.5082dupA:p.T1694fs

JARID2 83 MSI-H II Yes 6 15496728 15496728 G - frameshift_deletion JARID2:NM_001267040:exon7:c.756delG:p.G252fs

JMJD1C 83 MSI-H II Yes 10 64979702 64979702 C T synonymous_SNV JMJD1C:NM_032776:exon4:c.G489A:p.P163P

KDM4A 83 MSI-H II Yes 1 44131421 44131421 T G splicing mutation KDM4A(NM_014663:exon6:c.673+5T>G)

KDM4B 83 MSI-H II Yes 19 5135411 5135411 T C nonsynonymous_SNV KDM4B:NM_015015:exon15:c.T2147C:p.L716S

KDM5A 83 MSI-H II Yes 12 416960 416960 T - frameshift_deletion KDM5A:NM_001042603:exon23:c.3590delA:p.Q1197fs

LEPREL1 83 MSI-H II Yes 3 189838492 189838492 A G nonsynonymous_SNV LEPREL1:NM_018192:exon1:c.T29C:p.L10P

MAP2K2 83 MSI-H II Yes 19 4095391 4095391 A T nonsynonymous_SNV MAP2K2:NM_030662:exon9:c.T1041A:p.N347K

MAP2K4 83 MSI-H II Yes 17 12028607 12028607 C A splicing mutation MAP2K4(NM_003010:exon8:c.814-4C>A)

MAP2K7 83 MSI-H II Yes 19 7977294 7977294 C A nonsynonymous_SNV MAP2K7:NM_145185:exon11:c.C1238A:p.P413H

MAPK12 83 MSI-H II Yes 22 50694260 50694260 T C nonsynonymous_SNV MAPK12:NM_002969:exon8:c.A670G:p.T224A

MAPK13 83 MSI-H II Yes 6 36099119 36099120 TC - frameshift_deletion MAPK13:NM_002754:exon2:c.191_192del:p.64_64del

MAPK13 83 MSI-H II Yes 6 36099122 36099122 T - frameshift_deletion MAPK13:NM_002754:exon2:c.194delT:p.F65fs

MAPK15 83 MSI-H II Yes 8 144803227 144803227 C A nonsynonymous_SNV MAPK15:NM_139021:exon10:c.C975A:p.H325Q

MAPK7 83 MSI-H II Yes 17 19284440 19284440 T C synonymous_SNV MAPK7:NM_139032:exon2:c.T501C:p.P167P

MAPK8IP2 83 MSI-H II Yes 22 51045161 51045161 - G unknown UNKNOWN

MEN1 83 MSI-H II Yes 11 64572099 64572099 - G frameshift_insertion MEN1:NM_000244:exon10:c.1555dupC:p.P519fs

MLL2 83 MSI-H II Yes 12 49431879 49431879 C - frameshift_deletion MLL2:NM_003482:exon34:c.9260delG:p.R3087fs

MLL2 83 MSI-H II Yes 12 49420613 49420613 G A nonsynonymous_SNV MLL2:NM_003482:exon48:c.C15136T:p.P5046S

MLL4 83 MSI-H II Yes 19 36214876 36214876 C - frameshift_deletion MLL4:NM_014727:exon8:c.3302delC:p.P1101fs

MTOR 83 MSI-H II Yes 1 11294244 11294244 T C nonsynonymous_SNV MTOR:NM_004958:exon14:c.A2287G:p.N763D

NFKB1 83 MSI-H II Yes 4 103514659 103514659 G A nonsynonymous_SNV NFKB1:NM_001165412:exon12:c.G1141A:p.G381R

NFKB2 83 MSI-H II Yes 10 104156778 104156778 G A nonsynonymous_SNV NFKB2:NM_001261403:exon5:c.G361A:p.A121T

NTRK3 83 MSI-H II Yes 15 88679188 88679188 C T synonymous_SNV NTRK3:NM_001007156:exon9:c.G849A:p.T283T

OTX2 83 MSI-H II Yes 14 57271054 57271054 G - frameshift_deletion OTX2:NM_001270525:exon2:c.125delC:p.T42fs P2RX2 83 MSI-H II Yes 12 133197669 133197669 G A nonsynonymous_SNV P2RX2:NM_012226:exon6:c.G641A:p.R214Q

PHF10 83 MSI-H II Yes 6 170112521 170112521 A G synonymous_SNV PHF10:NM_018288:exon8:c.T918C:p.D306D

PIK3CG 83 MSI-H II Yes 7 106508133 106508133 G A nonsynonymous_SNV PIK3CG:NM_002649:exon2:c.G127A:p.V43M

PIK3R2 83 MSI-H II Yes 19 18279572 18279572 G A synonymous_SNV PIK3R2:NM_005027:exon15:c.G1845A:p.P615P

PIK3R5 83 MSI-H II Yes 17 8791872 8791872 C T nonsynonymous_SNV PIK3R5:NM_001251852:exon9:c.G74A:p.R25H

PLCB3 83 MSI-H II Yes 11 64031202 64031202 C T nonsynonymous_SNV PLCB3:NM_001184883:exon19:c.C2294T:p.P765L

PLCG1 83 MSI-H II Yes 20 39795196 39795196 G A nonsynonymous_SNV PLCG1:NM_002660:exon18:c.G2081A:p.R694Q

PMS2 83 MSI-H II Yes 7 6027164 6027164 T - frameshift_deletion PMS2:NM_000535:exon11:c.1232delA:p.E411fs

PRKDC 83 MSI-H II Yes 8 48766753 48766753 C T unknown UNKNOWN

PTEN 83 MSI-H II Yes 10 89711960 89711960 T C nonsynonymous_SNV PTEN:NM_000314:exon6:c.T578C:p.L193P

PTPN1 83 MSI-H II Yes 20 49196444 49196444 G A nonsynonymous_SNV PTPN1:NM_002827:exon8:c.G1069A:p.A357T

PTPN13 83 MSI-H II Yes 4 87622614 87622614 A - frameshift_deletion PTPN13:NM_006264:exon7:c.855delA:p.K285fs

PTPN23 83 MSI-H II Yes 3 47452328 47452328 - C frameshift_insertion PTPN23:NM_015466:exon20:c.3040dupC:p.L1014fs

PTPN5 83 MSI-H II Yes 11 18751370 18751370 C T splicing mutation PTPN5(NM_032781:exon14:c.1330-5G>A

PTPRK 83 MSI-H II Yes 6 128411064 128411064 G T synonymous_SNV PTPRK:NM_001135648:exon8:c.C1236A:p.S412S

PTPRM 83 MSI-H II Yes 18 8379161 8379161 G A splicing mutation PTPRM(NM_002845:exon26:c.3574-4G>A

RASGRP4 83 MSI-H II Yes 19 38912756 38912756 G A stopgain_SNV RASGRP4:NM_001146202:exon2:c.C61T:p.R21X

RPTOR 83 MSI-H II Yes 17 78931486 78931486 C T nonsynonymous_SNV RPTOR:NM_001163034:exon25:c.C2959T:p.R987W

RYR1 83 MSI-H II Yes 19 39018355 39018355 C T synonymous_SNV RYR1:NM_001042723:exon72:c.C10740T:p.D3580D

RYR2 83 MSI-H II Yes 1 237774174 237774174 T C nonsynonymous_SNV RYR2:NM_001035:exon36:c.T4796C:p.M1599T

RYR2 83 MSI-H II Yes 1 237754052 237754052 C T nonsynonymous_SNV RYR2:NM_001035:exon31:c.C3920T:p.P1307L

RYR2 83 MSI-H II Yes 1 237819149 237819149 C A nonsynonymous_SNV RYR2:NM_001035:exon53:c.C7994A:p.A2665E

RYR2 83 MSI-H II Yes 1 237947675 237947675 C T synonymous_SNV RYR2:NM_001035:exon90:c.C12663T:p.S4221S

SETD1A 83 MSI-H II Yes 16 30977381 30977381 G A nonsynonymous_SNV SETD1A:NM_014712:exon8:c.G2179A:p.G727S

SETD1B 83 MSI-H II Yes 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SETD1B 83 MSI-H II Yes 12 122261007 122261007 - C frameshift_insertion SETD1B:NM_015048:exon12:c.4393dupC:p.L1465fs

SETD1B 83 MSI-H II Yes 12 122255327 122255327 C T nonsynonymous_SNV SETD1B:NM_015048:exon8:c.C3029T:p.A1010V

SETD1B 83 MSI-H II Yes 12 122248249 122248249 C G synonymous_SNV SETD1B:NM_015048:exon5:c.C1398G:p.G466G

SLC4A4 83 MSI-H II Yes 4 72215732 72215732 A T nonsynonymous_SNV SLC4A4:NM_003759:exon2:c.A361T:p.M121L

SMAD7 83 MSI-H II Yes 18 46474802 46474802 G - frameshift_deletion SMAD7:NM_001190821:exon2:c.619delC:p.P207fs

SMARCA2 83 MSI-H II Yes 9 2039777 2039779 CAG - nonframeshift_deletion SMARCA2:NM_003070:exon4:c.667_669del:p.223_223del

SMARCA5 83 MSI-H II Yes 4 144468661 144468661 T C splicing mutation SMARCA5(NM_003601:exon21:c.2772+5T>C)

SMARCC2 83 MSI-H II Yes 12 56567552 56567552 C T synonymous_SNV SMARCC2:NM_001130420:exon17:c.G1578A:p.P526P

SMARCD3 83 MSI-H II Yes 7 150945596 150945596 A G nonsynonymous_SNV SMARCD3:NM_001003801:exon1:c.T53C:p.L18P SOCS3 83 MSI-H II Yes 17 76354669 76354669 C - frameshift_deletion SOCS3:NM_003955:exon2:c.508delG:p.G170fs

STAT5A 83 MSI-H II Yes 17 40453386 40453386 C T synonymous_SNV STAT5A:NM_003152:exon10:c.C1083T:p.N361N

STAT5B 83 MSI-H II Yes 17 40362453 40362453 T - frameshift_deletion STAT5B:NM_012448:exon14:c.1743delA:p.L581fs

TCF7L2 83 MSI-H II Yes 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TGFBR2 83 MSI-H II Yes 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

TK1 83 MSI-H II Yes 17 76170990 76170991 AC - frameshift_deletion TK1:NM_003258:exon7:c.554_555del:p.185_185del

TNK1 83 MSI-H II Yes 17 7287547 7287547 G A nonsynonymous_SNV TNK1:NM_001251902:exon6:c.G841A:p.G281R

TSC2 83 MSI-H II Yes 16 2136325 2136325 C T synonymous_SNV TSC2:NM_001077183:exon35:c.C4593T:p.D1531D

TYK2 83 MSI-H II Yes 19 10478988 10478988 C T nonsynonymous_SNV TYK2:NM_003331:exon4:c.G300A:p.M100I

UPP1 83 MSI-H II Yes 7 48147816 48147816 G A synonymous_SNV UPP1:NM_003364:exon9:c.G795A:p.A265A

ZAP70 83 MSI-H II Yes 2 98340517 98340517 G A synonymous_SNV ZAP70:NM_001079:exon3:c.G18A:p.A6A

SMARCA2 85 CIN III Yes 9 2039777 2039779 CAG - nonframeshift_deletion SMARCA2:NM_003070:exon4:c.667_669del:p.223_223del

APC 87 CIN III Yes 5 112175329 112175329 A - frameshift_deletion APC:NM_001127511:exon14:c.3984delA:p.S1328fs

ATP2B2 87 CIN III Yes 3 10382339 10382339 C A synonymous_SNV ATP2B2:NM_001683:exon17:c.G2832T:p.S944S

DDR1 87 CIN III Yes 6 30866810 30866810 G A nonsynonymous_SNV DDR1:NM_001202522:exon14:c.G2159A:p.R720Q

DPYD 87 CIN III Yes 1 97981406 97981406 C A nonsynonymous_SNV DPYD:NM_000110:exon13:c.G1616T:p.G539V

DPYS 87 CIN III Yes 8 105478986 105478986 C T nonsynonymous_SNV DPYS:NM_001385:exon1:c.G163A:p.A55T

EPHB1 87 CIN III Yes 3 134884812 134884812 G A nonsynonymous_SNV EPHB1:NM_004441:exon8:c.G1588A:p.D530N

KDM3B 87 CIN III Yes 5 137759918 137759918 - T frameshift_insertion KDM3B:NM_016604:exon16:c.4127dupT:p.L1376fs

KRAS 87 CIN III Yes 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

NTRK1 87 CIN III Yes 1 156848946 156848946 G T nonsynonymous_SNV NTRK1:NM_001012331:exon14:c.G1820T:p.G607V

PTPN7 87 CIN III Yes 1 202128555 202128555 G A synonymous_SNV PTPN7:NM_080588:exon1:c.C93T:p.P31P

PTPRS 87 CIN III Yes 19 5240268 5240268 C T nonsynonymous_SNV PTPRS:NM_130853:exon9:c.G1607A:p.R536Q

RYR1 87 CIN III Yes 19 38980792 38980792 G A nonsynonymous_SNV RYR1:NM_000540:exon36:c.G5891A:p.R1964H

TGFBR1 87 CIN III Yes 9 101867491 101867491 G - frameshift_deletion TGFBR1:NM_001130916:exon1:c.4delG:p.E2fs

APC 89 CIN II Yes 5 112162946 112162946 T A splicing mutation APC(NM_001127511:exon10:c.1494+2T>A

BAZ2B 89 CIN II Yes 2 160289357 160289357 G T nonsynonymous_SNV BAZ2B:NM_013450:exon9:c.C1811A:p.S604Y

BAZ2B 89 CIN II Yes 2 160289358 160289358 A G nonsynonymous_SNV BAZ2B:NM_013450:exon9:c.T1810C:p.S604P

DNMT3B 89 CIN II Yes 20 31376800 31376800 C T synonymous_SNV DNMT3B:NM_001207056:exon5:c.C567T:p.G189G

DPYD 89 CIN II Yes 1 98060680 98060680 G A nonsynonymous_SNV DPYD:NM_000110:exon9:c.C893T:p.T298M

EPHB1 89 CIN II Yes 3 134670732 134670732 A T nonsynonymous_SNV EPHB1:NM_004441:exon3:c.A643T:p.S215C

JMJD1C 89 CIN II Yes 10 64974717 64974717 T C nonsynonymous_SNV JMJD1C:NM_004241:exon5:c.A553G:p.K185E

PER1 89 CIN II Yes 17 8047173 8047174 GG - frameshift_deletion PER1:NM_002616:exon19:c.2482_2483del:p.828_828del

PTPRJ 89 CIN II Yes 11 48188876 48188876 G A nonsynonymous_SNV PTPRJ:NM_002843:exon25:c.G3976A:p.V1326M RGS16 89 CIN II Yes 1 182569478 182569478 G A synonymous_SNV RGS16:NM_002928:exon5:c.C558T:p.A186A

RYR1 89 CIN II Yes 19 39019018 39019018 G A nonsynonymous_SNV RYR1:NM_001042723:exon73:c.G10882A:p.V3628M

STAT6 89 CIN II Yes 12 57493826 57493826 A T synonymous_SNV STAT6:NM_001178081:exon12:c.T1230A:p.G410G

TP53 89 CIN II Yes 17 7577120 7577120 C T nonsynonymous_SNV TP53:NM_001126115:exon4:c.G422A:p.R141H

APC 91 CIN II Yes 5 112128187 112128187 T - frameshift_deletion APC:NM_000038:exon7:c.690delT:p.R230fs

APC 91 CIN II Yes 5 112170737 112170737 T - frameshift_deletion APC:NM_001127511:exon13:c.1779delT:p.G593fs

CACNA2D1 91 CIN II Yes 7 81624258 81624258 A T splicing mutation CACNA2D1(NM_000722:exon21:c.1663-3T>A)

CREBBP 91 CIN II Yes 16 3790439 3790439 G T stopgain_SNV CREBBP:NM_001079846:exon23:c.C3980A:p.S1327X

KRAS 91 CIN II Yes 12 25398284 25398284 C A nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35T:p.G12V

PAK2 91 CIN II Yes 3 196529926 196529926 C A synonymous_SNV PAK2:NM_002577:exon4:c.C327A:p.S109S

PDGFRB 91 CIN II Yes 5 149512377 149512377 G T nonsynonymous_SNV PDGFRB:NM_002609:exon7:c.C1063A:p.R355S

RASGRF1 91 CIN II Yes 15 79320174 79320174 C T synonymous_SNV RASGRF1:NM_001145648:exon9:c.G1290A:p.T430T

RYR1 91 CIN II Yes 19 38964225 38964225 C T nonsynonymous_SNV RYR1:NM_000540:exon28:c.C3974T:p.A1325V

SKI 91 CIN II Yes 1 2234730 2234730 G T nonsynonymous_SNV SKI:NM_003036:exon3:c.G1102T:p.G368C

SMG1 91 CIN II Yes 16 18852933 18852933 A C nonsynonymous_SNV SMG1:NM_015092:exon41:c.T6650G:p.L2217R

TP53 91 CIN II Yes 17 7577040 7577040 G - frameshift_deletion TP53:NM_001126115:exon4:c.502delC:p.P168fs

ACVR1 95 CIN III Yes 2 158617538 158617538 T C nonsynonymous_SNV ACVR1:NM_001105:exon9:c.A1118G:p.N373S

BRAF 95 CIN III Yes 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CHD5 95 CIN III Yes 1 6196810 6196810 C T nonsynonymous_SNV CHD5:NM_015557:exon16:c.G2552A:p.R851H

DPP10 95 CIN III Yes 2 116534786 116534786 T G nonsynonymous_SNV DPP10:NM_001004360:exon14:c.T1203G:p.S401R

GRIN2C 95 CIN III Yes 17 72838664 72838664 C T synonymous_SNV GRIN2C:NM_000835:exon13:c.G3612A:p.L1204L

PTPRC 95 CIN III Yes 1 198678956 198678956 G T splicing mutation PTPRC(NM_080921:exon8:c.688+3G>T

SKIL 95 CIN III Yes 3 170078433 170078433 C T nonsynonymous_SNV SKIL:NM_001145097:exon1:c.C314T:p.A105V

TP53 95 CIN III Yes 17 7577548 7577548 C T nonsynonymous_SNV TP53:NM_001126115:exon3:c.G337A:p.G113S

ACVR1C 101 MSI-L III No 2 158406843 158406843 T G synonymous_SNV ACVR1C:NM_001111032:exon3:c.A366C:p.G122G

ACVR2A 101 MSI-L III No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

AKAP6 101 MSI-L III No 14 32902734 32902734 G T nonsynonymous_SNV AKAP6:NM_004274:exon2:c.G35T:p.R12M

AKT1 101 MSI-L III No 14 105243111 105243111 C T splicing mutation AKT1(NM_001014431:exon5:c.176-4G>A

APC 101 MSI-L III No 5 112175676 112175677 AG - frameshift_deletion APC:NM_001127511:exon14:c.4331_4332del:p.1444_1444del

ARID1A 101 MSI-L III No 1 27105937 27105937 - G frameshift_insertion ARID1A:NM_006015:exon20:c.5548dupG:p.D1850fs

ARID1A 101 MSI-L III No 1 27101220 27101220 G A nonsynonymous_SNV ARID1A:NM_006015:exon18:c.G4502A:p.R1501H

ARID1B 101 MSI-L III No 6 157511252 157511252 A - frameshift_deletion ARID1B:NM_017519:exon14:c.3731delA:p.N1244fs

ATP2B4 101 MSI-L III No 1 203677053 203677053 A G nonsynonymous_SNV ATP2B4:NM_001001396:exon10:c.A1378G:p.T460A

ATR 101 MSI-L III No 3 142274749 142274749 T - frameshift_deletion ATR:NM_001184:exon10:c.2311delA:p.K771fs BMPR2 101 MSI-L III No 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

CACNA1A 101 MSI-L III No 19 13319691 13319691 G T nonsynonymous_SNV CACNA1A:NM_001127221:exon46:c.C6662A:p.P2221H

CACNA1C 101 MSI-L III No 12 2719716 2719716 G A nonsynonymous_SNV CACNA1C:NM_000719:exon28:c.G3568A:p.V1190M

CACNA1G 101 MSI-L III No 17 48703902 48703902 G A synonymous_SNV CACNA1G:NM_198387:exon34:c.G6543A:p.P2181P

CACNB2 101 MSI-L III No 10 18828605 18828605 - A frameshift_insertion CACNB2:NM_000724:exon13:c.1770dupA:p.K590fs

CBL 101 MSI-L III No 11 119169166 119169166 G A nonsynonymous_SNV CBL:NM_005188:exon15:c.G2350A:p.V784M

CCNE1 101 MSI-L III No 19 30303922 30303922 C T nonsynonymous_SNV CCNE1:NM_001238:exon4:c.C158T:p.A53V

CTNNA1 101 MSI-L III No 5 138223322 138223325 ATTG - frameshift_deletion CTNNA1:NM_001903:exon9:c.1287_1290del:p.429_430del

DAZAP2 101 MSI-L III No 12 51636207 51636207 A G nonsynonymous_SNV DAZAP2:NM_001136268:exon3:c.A226G:p.M76V

DPYD 101 MSI-L III No 1 97700433 97700433 A G nonsynonymous_SNV DPYD:NM_000110:exon19:c.T2417C:p.L806P

DVL2 101 MSI-L III No 17 7129776 7129776 A G nonsynonymous_SNV DVL2:NM_004422:exon14:c.T1726C:p.Y576H

EP300 101 MSI-L III No 22 41566531 41566531 A - frameshift_deletion EP300:NM_001429:exon27:c.4408delA:p.M1470fs

EP400 101 MSI-L III No 12 132538050 132538050 C A nonsynonymous_SNV EP400:NM_015409:exon43:c.C7636A:p.P2546T

EP400 101 MSI-L III No 12 132547138 132547138 A G synonymous_SNV EP400:NM_015409:exon47:c.A8226G:p.Q2742Q

FBXW7 101 MSI-L III No 4 153249385 153249385 G A nonsynonymous_SNV FBXW7:NM_001013415:exon8:c.C1039T:p.R347C

FLT1 101 MSI-L III No 13 28885838 28885838 A G nonsynonymous_SNV FLT1:NM_002019:exon27:c.T3524C:p.I1175T

FLT4 101 MSI-L III No 5 180055896 180055896 C T synonymous_SNV FLT4:NM_002020:exon8:c.G1089A:p.P363P

INSRR 101 MSI-L III No 1 156814510 156814510 G A nonsynonymous_SNV INSRR:NM_014215:exon13:c.C2563T:p.R855C

IRS1 101 MSI-L III No 2 227660963 227660963 T C nonsynonymous_SNV IRS1:NM_005544:exon1:c.A2492G:p.H831R

KDM5B 101 MSI-L III No 1 202710657 202710657 A G nonsynonymous_SNV KDM5B:NM_006618:exon19:c.T2783C:p.L928P

LEPRE1 101 MSI-L III No 1 43215941 43215941 G A nonsynonymous_SNV LEPRE1:NM_001146289:exon11:c.C1636T:p.R546W

MLH1 101 MSI-L III No 3 37042537 37042537 G A nonsynonymous_SNV MLH1:NM_000249:exon3:c.G299A:p.R100Q

MLL2 101 MSI-L III No 12 49445990 49445990 C T synonymous_SNV MLL2:NM_003482:exon10:c.G1476A:p.S492S

MLL3 101 MSI-L III No 7 151874156 151874156 T - frameshift_deletion MLL3:NM_170606:exon38:c.8382delA:p.P2794fs

NCK2 101 MSI-L III No 2 106498296 106498296 G A nonsynonymous_SNV NCK2:NM_001004720:exon3:c.G739A:p.V247I

P2RX7 101 MSI-L III No 12 121622538 121622538 G A nonsynonymous_SNV P2RX7:NM_002562:exon13:c.G1721A:p.R574H

PDGFRA 101 MSI-L III No 4 55138571 55138571 C T synonymous_SNV PDGFRA:NM_006206:exon9:c.C1248T:p.S416S

PIK3CB 101 MSI-L III No 3 138375074 138375074 C T synonymous_SNV PIK3CB:NM_001256045:exon12:c.G1521A:p.R507R

PTPRS 101 MSI-L III No 19 5239016 5239016 G A nonsynonymous_SNV PTPRS:NM_130853:exon10:c.C1724T:p.T575M

RET 101 MSI-L III No 10 43606814 43606814 C T nonsynonymous_SNV RET:NM_020630:exon7:c.C1423T:p.R475W

SETD1B 101 MSI-L III No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SHC1 101 MSI-L III No 1 154941048 154941048 G T nonsynonymous_SNV SHC1:NM_001130040:exon4:c.C673A:p.L225M

SMAD9 101 MSI-L III No 13 37427588 37427588 T C nonsynonymous_SNV SMAD9:NM_005905:exon5:c.A1117G:p.K373E

STAT3 101 MSI-L III No 17 40485988 40485988 A G nonsynonymous_SNV STAT3:NM_003150:exon9:c.T877C:p.Y293H STAT5A 101 MSI-L III No 17 40459465 40459465 G A nonsynonymous_SNV STAT5A:NM_003152:exon15:c.G1726A:p.G576R

STRADA 101 MSI-L III No 17 61781082 61781082 G A synonymous_SNV STRADA:NM_001003786:exon11:c.C1062T:p.P354P

SYNGAP1 101 MSI-L III No 6 33411531 33411531 T C synonymous_SNV SYNGAP1:NM_006772:exon15:c.T3202C:p.L1068L

TCF7L2 101 MSI-L III No 10 114925324 114925325 AA - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1158_1159del:p.386_387del

TCF7L2 101 MSI-L III No 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TGFBR2 101 MSI-L III No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

ATP2B2 105 CIN III Yes 3 10420033 10420033 G A synonymous_SNV ATP2B2:NM_001683:exon7:c.C969T:p.G323G

CACNA1S 105 CIN III Yes 1 201016339 201016339 G A synonymous_SNV CACNA1S:NM_000069:exon38:c.C4572T:p.Y1524Y

DOCK3 105 CIN III Yes 3 51349932 51349932 C A nonsynonymous_SNV DOCK3:NM_004947:exon30:c.C3119A:p.A1040E

EPHA5 105 CIN III Yes 4 66201726 66201726 C T nonsynonymous_SNV EPHA5:NM_182472:exon15:c.G2710A:p.D904N

IKBKE 105 CIN III Yes 1 206650076 206650076 G T nonsynonymous_SNV IKBKE:NM_001193321:exon6:c.G341T:p.G114V

JMJD4 105 CIN III Yes 1 227923085 227923085 G A synonymous_SNV JMJD4:NM_001161465:exon1:c.C28T:p.L10L

KDM5C 105 CIN III Yes X 53245264 53245264 C T nonsynonymous_SNV KDM5C:NM_001146702:exon4:c.G572A:p.R191Q

KRAS 105 CIN III Yes 12 25398284 25398284 C A nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35T:p.G12V

LEPRE1 105 CIN III Yes 1 43223532 43223532 G A synonymous_SNV LEPRE1:NM_001146289:exon5:c.C1002T:p.D334D

MAP2K3 105 CIN III Yes 17 21215473 21215473 G A nonsynonymous_SNV MAP2K3:NM_002756:exon10:c.G707A:p.R236Q

MAPK13 105 CIN III Yes 6 36099137 36099137 A G nonsynonymous_SNV MAPK13:NM_002754:exon2:c.A209G:p.Y70C

PDGFRB 105 CIN III Yes 5 149513520 149513520 C T nonsynonymous_SNV PDGFRB:NM_002609:exon5:c.G683A:p.G228D

SMAD4 105 CIN III Yes 18 48584560 48584560 C T stopgain_SNV SMAD4:NM_005359:exon6:c.C733T:p.Q245X

TCF7L2 105 CIN III Yes 10 114925333 114925333 C A nonsynonymous_SNV TCF7L2:NM_001198530:exon11:c.C1167A:p.F389L

ZAP70 105 CIN III Yes 2 98341631 98341631 G A nonsynonymous_SNV ZAP70:NM_001079:exon4:c.G479A:p.R160Q

BRAF 107 CIN III No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

FNDC1 107 CIN III No 6 159654227 159654227 C T nonsynonymous_SNV FNDC1:NM_032532:exon11:c.C2683T:p.P895S

GNAS 107 CIN III No 20 57484420 57484420 C T nonsynonymous_SNV GNAS:NM_001077489:exon7:c.C556T:p.R186C

PIK3CA 107 CIN III No 3 178936082 178936082 G A nonsynonymous_SNV p.E542K

PLCE1 107 CIN III No 10 96058241 96058241 C T nonsynonymous_SNV PLCE1:NM_001165979:exon23:c.C4349T:p.S1450L

RYR2 107 CIN III No 1 237947675 237947675 C T synonymous_SNV RYR2:NM_001035:exon90:c.C12663T:p.S4221S

TP53 107 CIN III No 17 7577538 7577538 C T nonsynonymous_SNV TP53:NM_001126115:exon3:c.G347A:p.R116Q

CACNA1B 109 CIN III No 9 140807659 140807659 C T synonymous_SNV CACNA1B:NM_000718:exon4:c.C558T:p.F186F

GNAS 109 CIN III No 20 57429096 57429096 C T nonsynonymous_SNV GNAS:NM_001077490:exon1:c.C589T:p.R197W

KRAS 109 CIN III No 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

NAV3 109 CIN III No 12 78400423 78400423 C T nonsynonymous_SNV NAV3:NM_014903:exon8:c.C1105T:p.P369S

NAV3 109 CIN III No 12 78569092 78569092 G A nonsynonymous_SNV NAV3:NM_014903:exon25:c.G4988A:p.R1663H

PIK3CA 109 CIN III No 3 178936082 178936082 G A nonsynonymous_SNV p.E542K RPTOR 109 CIN III No 17 78936363 78936363 G A synonymous_SNV RPTOR:NM_001163034:exon28:c.G3321A:p.A1107A

RYR1 109 CIN III No 19 38933073 38933073 A G nonsynonymous_SNV RYR1:NM_000540:exon3:c.A250G:p.T84A

SLC24A2 109 CIN III No 9 19521055 19521055 C T nonsynonymous_SNV SLC24A2:NM_001193288:exon8:c.G1522A:p.G508R

SMAD4 109 CIN III No 18 48604790 48604790 G T stopgain_SNV SMAD4:NM_005359:exon12:c.G1612T:p.E538X

TP53 109 CIN III No 17 7577055 7577055 G A nonsynonymous_SNV TP53:NM_001126115:exon4:c.C487T:p.P163S

TP53 109 CIN III No 17 7578272 7578272 G A nonsynonymous_SNV TP53:NM_001126115:exon2:c.C181T:p.H61Y

BRAF 119 CIN II No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

BTK 119 CIN II No X 100630137 100630137 G A nonsynonymous_SNV BTK:NM_000061:exon2:c.C136T:p.R46C

CACNA1I 119 CIN II No 22 40045824 40045824 C T nonsynonymous_SNV CACNA1I:NM_001003406:exon9:c.C1781T:p.T594M

CACNA2D1 119 CIN II No 7 81964543 81964543 A G nonsynonymous_SNV CACNA2D1:NM_000722:exon3:c.T202C:p.Y68H

CDKN1B 119 CIN II No 12 12870845 12870845 - C frameshift_insertion CDKN1B:NM_004064:exon1:c.72dupC:p.P24fs

CTNNA2 119 CIN II No 2 80831307 80831307 A C splicing mutation CTNNA2(NM_001164883:exon16:c.2295+3A>C

CTNND2 119 CIN II No 5 11364822 11364822 T A nonsynonymous_SNV CTNND2:NM_001332:exon8:c.A1358T:p.Y453F

GNAS 119 CIN II No 20 57415601 57415601 C T nonsynonymous_SNV GNAS:NM_016592:exon1:c.C440T:p.P147L

ITPR3 119 CIN II No 6 33646211 33646211 T C nonsynonymous_SNV ITPR3:NM_002224:exon29:c.T3662C:p.M1221T

ITPR3 119 CIN II No 6 33646200 33646200 T C synonymous_SNV ITPR3:NM_002224:exon29:c.T3651C:p.G1217G

PTPRT 119 CIN II No 20 40735547 40735547 C T nonsynonymous_SNV PTPRT:NM_007050:exon24:c.G3269A:p.R1090Q

RAF1 119 CIN II No 3 12653531 12653531 C T nonsynonymous_SNV RAF1:NM_002880:exon3:c.G238A:p.D80N

RICTOR 119 CIN II No 5 38950497 38950497 G T synonymous_SNV RICTOR:NM_152756:exon31:c.C3453A:p.S1151S

RYR2 119 CIN II No 1 237947633 237947633 G A synonymous_SNV RYR2:NM_001035:exon90:c.G12621A:p.S4207S

SMAD4 119 CIN II No 18 48591918 48591918 C T nonsynonymous_SNV SMAD4:NM_005359:exon9:c.C1081T:p.R361C

TP53 119 CIN II No 17 7578406 7578406 C T nonsynonymous_SNV TP53:NM_001126115:exon1:c.G128A:p.R43H

ABL2 121 MSI-H II No 1 179078409 179078409 - G frameshift_insertion ABL2:NM_001168236:exon11:c.1930dupC:p.P644fs

ABL2 121 MSI-H II No 1 179090959 179090959 A G nonsynonymous_SNV ABL2:NM_001136001:exon4:c.T668C:p.L223P

ACVR1B 121 MSI-H II No 12 52377924 52377924 T C nonsynonymous_SNV ACVR1B:NM_004302:exon5:c.T953C:p.L318P

ACVR2A 121 MSI-H II No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ADAMTSL3 121 MSI-H II No 15 84488750 84488750 C T nonsynonymous_SNV ADAMTSL3:NM_207517:exon6:c.C551T:p.T184I

AKAP4 121 MSI-H II No X 49958068 49958068 A G synonymous_SNV AKAP4:NM_003886:exon5:c.T1296C:p.S432S

AKAP9 121 MSI-H II No 7 91730292 91730292 A G synonymous_SNV AKAP9:NM_005751:exon45:c.A11019G:p.V3673V

APC2 121 MSI-H II No 19 1466621 1466621 G T nonsynonymous_SNV APC2:NM_005883:exon15:c.G3321T:p.E1107D

ARID1B 121 MSI-H II No 6 157521999 157521999 C T nonsynonymous_SNV ARID1B:NM_017519:exon17:c.C4232T:p.P1411L

ARID2 121 MSI-H II No 12 46298712 46298712 - T splicing mutation ARID2(NM_152641:exon21:c.5364-5->T)

ATP2A3 121 MSI-H II No 17 3854597 3854597 C T synonymous_SNV ATP2A3:NM_005173:exon5:c.G411A:p.V137V

ATR 121 MSI-H II No 3 142274749 142274749 T - frameshift_deletion ATR:NM_001184:exon10:c.2311delA:p.K771fs BLK 121 MSI-H II No 8 11414191 11414191 T C nonsynonymous_SNV BLK:NM_001715:exon9:c.T797C:p.V266A

BMPR2 121 MSI-H II No 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BRAF 121 MSI-H II No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

BTK 121 MSI-H II No X 100614312 100614312 C T nonsynonymous_SNV BTK:NM_000061:exon10:c.G863A:p.R288Q

CACNA1A 121 MSI-H II No 19 13386727 13386727 C T nonsynonymous_SNV CACNA1A:NM_001127221:exon24:c.G3929A:p.R1310H

CACNA1B 121 MSI-H II No 9 140772628 140772628 C T synonymous_SNV CACNA1B:NM_000718:exon1:c.C243T:p.D81D

CACNA1D 121 MSI-H II No 3 53707845 53707845 T C splicing mutation CACNA1D(NM_000720:exon8:c.1220+2T>C)

CACNA1H 121 MSI-H II No 16 1270131 1270131 G A nonsynonymous_SNV CACNA1H:NM_001005407:exon34:c.G6181A:p.V2061I

CACNA1H 121 MSI-H II No 16 1270532 1270532 C T synonymous_SNV CACNA1H:NM_001005407:exon34:c.C6582T:p.D2194D

CACNA1S 121 MSI-H II No 1 201047217 201047217 A G nonsynonymous_SNV CACNA1S:NM_000069:exon11:c.T1409C:p.V470A

CACNA2D1 121 MSI-H II No 7 81964519 81964519 G A nonsynonymous_SNV CACNA2D1:NM_000722:exon3:c.C226T:p.R76C

CACNG1 121 MSI-H II No 17 65051245 65051245 G A nonsynonymous_SNV CACNG1:NM_000727:exon3:c.G331A:p.A111T

CAMK2B 121 MSI-H II No 7 44273994 44273994 C T nonsynonymous_SNV CAMK2B:NM_172079:exon14:c.G1054A:p.A352T

CD38 121 MSI-H II No 4 15780231 15780231 C T nonsynonymous_SNV CD38:NM_001775:exon1:c.C194T:p.A65V

CDKN1A 121 MSI-H II No 6 36651995 36651995 G A synonymous_SNV CDKN1A:NM_000389:exon2:c.G117A:p.A39A

CHD3 121 MSI-H II No 17 7798771 7798771 C - frameshift_deletion CHD3:NM_001005271:exon10:c.1795delC:p.R599fs

CHD3 121 MSI-H II No 17 7800465 7800465 C - frameshift_deletion CHD3:NM_001005271:exon11:c.1949delC:p.P650fs

CHD4 121 MSI-H II No 12 6711552 6711552 T - frameshift_deletion CHD4:NM_001273:exon3:c.212delA:p.Q71fs

CHD4 121 MSI-H II No 12 6691425 6691425 G A nonsynonymous_SNV CHD4:NM_001273:exon30:c.C4393T:p.R1465W

CHD9 121 MSI-H II No 16 53342681 53342681 G A synonymous_SNV CHD9:NM_025134:exon34:c.G7089A:p.Q2363Q

CREBBP 121 MSI-H II No 16 3779419 3779419 C T nonsynonymous_SNV CREBBP:NM_001079846:exon30:c.G5515A:p.V1839M

CRTC2 121 MSI-H II No 1 153923747 153923747 A G nonsynonymous_SNV CRTC2:NM_181715:exon11:c.T1393C:p.S465P

CTNNA2 121 MSI-H II No 2 80831273 80831273 T C nonsynonymous_SNV CTNNA2:NM_001164883:exon16:c.T2264C:p.M755T

DNAH3 121 MSI-H II No 16 20996908 20996908 T G nonsynonymous_SNV DNAH3:NM_017539:exon48:c.A7156C:p.T2386P

DOCK3 121 MSI-H II No 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

DOCK3 121 MSI-H II No 3 51266202 51266202 C T synonymous_SNV DOCK3:NM_004947:exon18:c.C1758T:p.R586R

DPP10 121 MSI-H II No 2 116599793 116599793 C A nonsynonymous_SNV DPP10:NM_001004360:exon26:c.C2242A:p.P748T

DRD3 121 MSI-H II No 3 113890768 113890768 G A synonymous_SNV DRD3:NM_000796:exon2:c.C72T:p.S24S

DVL1 121 MSI-H II No 1 1274747 1274747 C T nonsynonymous_SNV DVL1:NM_004421:exon11:c.G1127A:p.R376H

DVL2 121 MSI-H II No 17 7129186 7129186 A G stoploss_SNV DVL2:NM_004422:exon15:c.T2209C:p.X737Q

EP400 121 MSI-H II No 12 132547094 132547096 CAG - nonframeshift_deletion EP400:NM_015409:exon47:c.8182_8184del:p.2728_2728del

EP400 121 MSI-H II No 12 132530043 132530043 A C nonsynonymous_SNV EP400:NM_015409:exon38:c.A6964C:p.T2322P

EPHB3 121 MSI-H II No 3 184298917 184298917 C T nonsynonymous_SNV EPHB3:NM_004443:exon14:c.C2696T:p.A899V

EPHB4 121 MSI-H II No 7 100404183 100404183 C A nonsynonymous_SNV EPHB4:NM_004444:exon14:c.G2343T:p.K781N FBXW7 121 MSI-H II No 4 153258989 153258989 A G nonsynonymous_SNV FBXW7:NM_001013415:exon4:c.T472C:p.F158L

FLT3 121 MSI-H II No 13 28608113 28608113 G T stopgain_SNV FLT3:NM_004119:exon15:c.C1853A:p.S618X

HCFC2 121 MSI-H II No 12 104476542 104476542 - A frameshift_insertion HCFC2:NM_013320:exon7:c.926dupA:p.N309fs

HDAC10 121 MSI-H II No 22 50687596 50687596 A T nonsynonymous_SNV HDAC10:NM_001159286:exon8:c.T692A:p.V231D

HDAC2 121 MSI-H II No 6 114292048 114292048 T - frameshift_deletion HDAC2:NM_001527:exon1:c.25delA:p.K9fs

HDAC3 121 MSI-H II No 5 141008782 141008782 C T nonsynonymous_SNV HDAC3:NM_003883:exon7:c.G568A:p.V190M

INSRR 121 MSI-H II No 1 156819066 156819066 G - frameshift_deletion INSRR:NM_014215:exon6:c.1416delC:p.N472fs

ITPR2 121 MSI-H II No 12 26640052 26640052 T - frameshift_deletion ITPR2:NM_002223:exon40:c.5503delA:p.K1835fs

ITPR3 121 MSI-H II No 6 33662819 33662819 T G nonsynonymous_SNV ITPR3:NM_002224:exon57:c.T7904G:p.L2635R

ITPR3 121 MSI-H II No 6 33626605 33626605 C T synonymous_SNV ITPR3:NM_002224:exon5:c.C528T:p.N176N

JMJD1C 121 MSI-H II No 10 64952706 64952706 T - frameshift_deletion JMJD1C:NM_004241:exon13:c.5357delA:p.E1786fs

JMJD1C 121 MSI-H II No 10 64975437 64975437 A G nonsynonymous_SNV JMJD1C:NM_004241:exon3:c.T41C:p.V14A

KAT6A 121 MSI-H II No 8 41790658 41790658 G - frameshift_deletion KAT6A:NM_006766:exon17:c.5080delC:p.P1694fs

KDM3B 121 MSI-H II No 5 137735677 137735677 C T nonsynonymous_SNV KDM3B:NM_016604:exon11:c.C3175T:p.L1059F

KDM5A 121 MSI-H II No 12 416960 416960 T - frameshift_deletion KDM5A:NM_001042603:exon23:c.3590delA:p.Q1197fs

KDM5A 121 MSI-H II No 12 416129 416129 A T nonsynonymous_SNV KDM5A:NM_001042603:exon24:c.T4057A:p.Y1353N

KDM5C 121 MSI-H II No X 53222376 53222376 C A nonsynonymous_SNV KDM5C:NM_004187:exon26:c.G4456T:p.G1486W

KDM5C 121 MSI-H II No X 53222750 53222750 G A nonsynonymous_SNV KDM5C:NM_001146702:exon23:c.C3976T:p.R1326W

MAPK4 121 MSI-H II No 18 48190490 48190490 C T synonymous_SNV MAPK4:NM_002747:exon2:c.C162T:p.S54S

MLH3 121 MSI-H II No 14 75483839 75483840 CT - frameshift_deletion MLH3:NM_014381:exon12:c.4235_4236del:p.1412_1412del

MLH3 121 MSI-H II No 14 75483840 75483840 T - frameshift_deletion MLH3:NM_014381:exon12:c.4235delA:p.E1412fs

MLL2 121 MSI-H II No 12 49444884 49444884 G A nonsynonymous_SNV MLL2:NM_003482:exon10:c.C2582T:p.S861F

MLL4 121 MSI-H II No 19 36223007 36223007 G - frameshift_deletion MLL4:NM_014727:exon27:c.5636delG:p.G1879fs

MTOR 121 MSI-H II No 1 11190693 11190693 C T nonsynonymous_SNV MTOR:NM_004958:exon39:c.G5506A:p.A1836T

MTRR 121 MSI-H II No 5 7883348 7883348 T C synonymous_SNV MTRR:NM_002454:exon6:c.T861C:p.N287N

MYC 121 MSI-H II No 8 128752752 128752754 CCT - nonframeshift_deletion MYC:NM_002467:exon3:c.913_915del:p.305_305del

MYC 121 MSI-H II No 8 128750493 128750493 G A splicing mutation MYC(NM_002467:exon2:c.31-1G>A)

NFKBIZ 121 MSI-H II No 3 101572179 101572179 A G nonsynonymous_SNV NFKBIZ:NM_031419:exon5:c.A809G:p.Q270R

OTX2 121 MSI-H II No 14 57271054 57271054 G - frameshift_deletion OTX2:NM_001270525:exon2:c.125delC:p.T42fs

P2RX3 121 MSI-H II No 11 57135556 57135556 G A nonsynonymous_SNV P2RX3:NM_002559:exon9:c.G916A:p.D306N

PER1 121 MSI-H II No 17 8050894 8050894 G - frameshift_deletion PER1:NM_002616:exon12:c.1391delC:p.A464fs

PIK3C3 121 MSI-H II No 18 39575909 39575909 C G nonsynonymous_SNV PIK3C3:NM_002647:exon8:c.C842G:p.P281R

PIK3CA 121 MSI-H II No 3 178936095 178936095 A G nonsynonymous_SNV PIK3CA:NM_006218:exon10:c.A1637G:p.Q546R

PLCB3 121 MSI-H II No 11 64029998 64029998 G A nonsynonymous_SNV PLCB3:NM_001184883:exon16:c.G1957A:p.V653M PLCB3 121 MSI-H II No 11 64033504 64033504 T C nonsynonymous_SNV PLCB3:NM_001184883:exon24:c.T2981C:p.L994P

PRKD1 121 MSI-H II No 14 30046561 30046561 G A synonymous_SNV PRKD1:NM_002742:exon18:c.C2622T:p.G874G

PTPN13 121 MSI-H II No 4 87655611 87655611 T A splicing mutation PTPN13(NM_080685:exon13:c.2012+2T>A

PTPRK 121 MSI-H II No 6 128326393 128326393 C T splicing mutation PTPRK(NM_001135648:exon16:c.2334-4G>A

PTPRM 121 MSI-H II No 18 8069951 8069951 G A nonsynonymous_SNV PTPRM:NM_001105244:exon8:c.G1400A:p.R467Q

PTPRZ1 121 MSI-H II No 7 121651741 121651741 T C nonsynonymous_SNV PTPRZ1:NM_002851:exon12:c.T2641C:p.S881P

RASGRP2 121 MSI-H II No 11 64496513 64496513 G T synonymous_SNV RASGRP2:NM_001098670:exon15:c.C1593A:p.A531A

RNF111 121 MSI-H II No 15 59368377 59368378 CT - frameshift_deletion RNF111:NM_001270528:exon7:c.1911_1912del:p.637_638del

RNF111 121 MSI-H II No 15 59376348 59376348 C - frameshift_deletion RNF111:NM_001270528:exon9:c.2345delC:p.P782fs

RYR1 121 MSI-H II No 19 39025847 39025847 C T nonsynonymous_SNV RYR1:NM_001042723:exon79:c.C11411T:p.A3804V

RYR1 121 MSI-H II No 19 38949874 38949874 G A synonymous_SNV RYR1:NM_000540:exon19:c.G2256A:p.P752P

RYR2 121 MSI-H II No 1 237969502 237969502 T - frameshift_deletion RYR2:NM_001035:exon99:c.14217delT:p.F4739fs

RYR2 121 MSI-H II No 1 237947546 237947546 C T synonymous_SNV RYR2:NM_001035:exon90:c.C12534T:p.N4178N

SETD1A 121 MSI-H II No 16 30976539 30976539 C T synonymous_SNV SETD1A:NM_014712:exon7:c.C1476T:p.I492I

SETD1B 121 MSI-H II No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SLC24A3 121 MSI-H II No 20 19698240 19698240 A C splicing mutation SLC24A3(NM_020689:exon16:c.1785+3A>C)

SLC8A2 121 MSI-H II No 19 47969008 47969008 A - frameshift_deletion SLC8A2:NM_015063:exon2:c.653delT:p.V218fs

SMAD9 121 MSI-H II No 13 37422934 37422934 C T nonsynonymous_SNV SMAD9:NM_005905:exon6:c.G1172A:p.R391H

SMAD9 121 MSI-H II No 13 37446942 37446942 C T nonsynonymous_SNV SMAD9:NM_001127217:exon3:c.G523A:p.A175T

SMARCA2 121 MSI-H II No 9 2123810 2123810 T C nonsynonymous_SNV SMARCA2:NM_003070:exon27:c.T3854C:p.I1285T

TGFBR2 121 MSI-H II No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

TRIM33 121 MSI-H II No 1 115053200 115053200 C - frameshift_deletion TRIM33:NM_015906:exon1:c.498delG:p.P166fs

TRRAP 121 MSI-H II No 7 98513432 98513432 G A synonymous_SNV TRRAP:NM_001244580:exon19:c.G2286A:p.A762A

TYMP 121 MSI-H II No 22 50967582 50967582 C T nonsynonymous_SNV TYMP:NM_001113756:exon2:c.G400A:p.A134T

UCK1 121 MSI-H II No 9 134406498 134406498 G A nonsynonymous_SNV UCK1:NM_001135954:exon1:c.C64T:p.R22W

UCKL1 121 MSI-H II No 20 62572469 62572469 A G nonsynonymous_SNV UCKL1:NM_001193379:exon9:c.T971C:p.I324T

APC 123 CIN II No 5 112128191 112128191 C T stopgain_SNV APC:NM_000038:exon7:c.C694T:p.R232X

PTPRM 123 CIN II No 18 8296395 8296395 G C nonsynonymous_SNV PTPRM:NM_002845:exon18:c.G2745C:p.W915C

TP53 123 CIN II No 17 7578508 7578508 C T nonsynonymous_SNV TP53:NM_001126115:exon1:c.G26A:p.C9Y

TRIM33 123 CIN II No 1 114964217 114964217 C T synonymous_SNV TRIM33:NM_015906:exon11:c.G1902A:p.S634S

ACVR1C 127 CIN II Yes 2 158399220 158399220 C T synonymous_SNV ACVR1C:NM_001111033:exon4:c.G627A:p.K209K

FNDC1 127 CIN II Yes 6 159672373 159672373 C T nonsynonymous_SNV FNDC1:NM_032532:exon17:c.C4874T:p.P1625L

SLC8A1 127 CIN II Yes 2 40656262 40656262 C T nonsynonymous_SNV SLC8A1:NM_001112800:exon1:c.G1159A:p.A387T

TCF7L2 127 CIN II Yes 10 114925333 114925333 C T nonsynonymous_SNV TCF7L2:NM_001146285:exon13:c.C1342T:p.R448C APC 129 CIN III No 5 112151204 112151204 C T stopgain_SNV APC:NM_001127511:exon7:c.C793T:p.R265X

CACNA1A 129 CIN III No 19 13318673 13318673 C - frameshift_deletion CACNA1A:NM_001127222:exon47:c.6975delG:p.Q2325fs

CACNA1A 129 CIN III No 19 13318675 13318675 G - frameshift_deletion CACNA1A:NM_001127222:exon47:c.6973delC:p.Q2325fs

EPHB1 129 CIN III No 3 134851584 134851584 C T synonymous_SNV EPHB1:NM_004441:exon5:c.C990T:p.I330I

GNAS 129 CIN III No 20 57429227 57429227 G A stopgain_SNV GNAS:NM_001077490:exon1:c.G720A:p.W240X

HOXA3 129 CIN III No 7 27150174 27150174 T C nonsynonymous_SNV HOXA3:NM_030661:exon2:c.A86G:p.N29S

MAPKBP1 129 CIN III No 15 42109650 42109650 G A synonymous_SNV MAPKBP1:NM_001265611:exon15:c.G1776A:p.A592A

PDGFRA 129 CIN III No 4 55152018 55152018 G A nonsynonymous_SNV PDGFRA:NM_006206:exon18:c.G2450A:p.R817H

RYR2 129 CIN III No 1 237804241 237804241 C T nonsynonymous_SNV RYR2:NM_001035:exon47:c.C7160T:p.A2387V

TEK 129 CIN III No 9 27212815 27212815 G A nonsynonymous_SNV TEK:NM_000459:exon17:c.G2797A:p.A933T

TP53 129 CIN III No 17 7578382 7578382 G C stopgain_SNV TP53:NM_001126115:exon1:c.C152G:p.S51X

ACVR2A 131 MSI-H III No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

AKAP2,PALM2-AKAP2 131 MSI-H III No 9 112900489 112900489 C - frameshift_deletion AKAP2:NM_001004065:exon2:c.2239delC:p.Q747fs

AKAP9 131 MSI-H III No 7 91708560 91708560 A G synonymous_SNV AKAP9:NM_005751:exon31:c.A7113G:p.S2371S

AKT1 131 MSI-H III No 14 105246482 105246482 C T nonsynonymous_SNV AKT1:NM_001014431:exon3:c.G118A:p.E40K

ARID1B 131 MSI-H III No 6 157099166 157099168 TCC - nonframeshift_deletion ARID1B:NM_017519:exon1:c.103_105del:p.35_35del

ARID1B 131 MSI-H III No 6 157527903 157527903 C T synonymous_SNV ARID1B:NM_017519:exon19:c.C5589T:p.T1863T

ATP2A2 131 MSI-H III No 12 110784025 110784025 C T nonsynonymous_SNV ATP2A2:NM_001681:exon20:c.C2879T:p.P960L

ATRX 131 MSI-H III No X 76972620 76972620 T A nonsynonymous_SNV ATRX:NM_000489:exon2:c.A121T:p.N41Y

BLK 131 MSI-H III No 8 11421558 11421558 C T stopgain_SNV BLK:NM_001715:exon13:c.C1459T:p.Q487X

BRAF 131 MSI-H III No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1A 131 MSI-H III No 19 13428082 13428082 - A frameshift_insertion CACNA1A:NM_001127221:exon11:c.1402dupT:p.F468fs

CACNA1B 131 MSI-H III No 9 140901270 140901270 C A nonsynonymous_SNV CACNA1B:NM_000718:exon16:c.C2026A:p.Q676K

CACNA1E 131 MSI-H III No 1 181549881 181549881 C A nonsynonymous_SNV CACNA1E:NM_000721:exon6:c.C920A:p.T307N

CACNB1 131 MSI-H III No 17 37331696 37331696 C A nonsynonymous_SNV CACNB1:NM_000723:exon14:c.G1547T:p.G516V

CHD4 131 MSI-H III No 12 6711145 6711146 TC - frameshift_deletion CHD4:NM_001273:exon4:c.418_419del:p.140_140del

CHD4 131 MSI-H III No 12 6703686 6703686 T C nonsynonymous_SNV CHD4:NM_001273:exon15:c.A2252G:p.D751G

CSK 131 MSI-H III No 15 75091758 75091758 C T nonsynonymous_SNV CSK:NM_004383:exon5:c.C388T:p.R130C

CTNNA2 131 MSI-H III No 2 80101428 80101428 C T nonsynonymous_SNV CTNNA2:NM_001164883:exon6:c.C812T:p.T271M

DNMT3A 131 MSI-H III No 2 25470503 25470503 C T nonsynonymous_SNV DNMT3A:NM_153759:exon4:c.G404A:p.G135D

DRD2 131 MSI-H III No 11 113286299 113286299 G A synonymous_SNV DRD2:NM_000795:exon5:c.C567T:p.F189F

EP400 131 MSI-H III No 12 132547094 132547095 CA - frameshift_deletion EP400:NM_015409:exon47:c.8182_8183del:p.2728_2728del

EPHA4 131 MSI-H III No 2 222321386 222321386 G A nonsynonymous_SNV EPHA4:NM_004438:exon7:c.C1550T:p.T517I

ERBB2 131 MSI-H III No 17 37872039 37872039 G T nonsynonymous_SNV ERBB2:NM_004448:exon12:c.G1360T:p.G454W ERBB4 131 MSI-H III No 2 212426637 212426637 C A nonsynonymous_SNV ERBB4:NM_001042599:exon20:c.G2478T:p.Q826H

FHOD3 131 MSI-H III No 18 34205521 34205521 C - frameshift_deletion FHOD3:NM_025135:exon10:c.1005delC:p.P335fs

GNAQ 131 MSI-H III No 9 80646123 80646123 C T nonsynonymous_SNV GNAQ:NM_002072:exon1:c.G29A:p.C10Y

GNAS 131 MSI-H III No 20 57430299 57430299 G A nonsynonymous_SNV GNAS:NM_001077490:exon1:c.G1792A:p.A598T

GPC5 131 MSI-H III No 13 92345889 92345889 C T synonymous_SNV GPC5:NM_004466:exon3:c.C774T:p.C258C

GRIN1 131 MSI-H III No 9 140051409 140051409 C T synonymous_SNV GRIN1:NM_000832:exon6:c.C888T:p.L296L

HDAC7 131 MSI-H III No 12 48188561 48188561 A G synonymous_SNV HDAC7:NM_001098416:exon11:c.T1329C:p.P443P

JAK2 131 MSI-H III No 9 5078346 5078346 A - frameshift_deletion JAK2:NM_004972:exon16:c.2033delA:p.N678fs

JMJD1C 131 MSI-H III No 10 65140143 65140143 C T nonsynonymous_SNV JMJD1C:NM_032776:exon2:c.G268A:p.A90T

KDR 131 MSI-H III No 4 55948198 55948198 G A nonsynonymous_SNV KDR:NM_002253:exon29:c.C3773T:p.T1258M

LMTK2 131 MSI-H III No 7 97823755 97823755 C T synonymous_SNV LMTK2:NM_014916:exon11:c.C3978T:p.D1326D

MAPK8IP3 131 MSI-H III No 16 1816651 1816651 T C splicing mutation MAPK8IP3(NM_001040439:exon22:c.2918+2T>C

MLL3 131 MSI-H III No 7 151874156 151874156 T - frameshift_deletion MLL3:NM_170606:exon38:c.8382delA:p.P2794fs

MLL3 131 MSI-H III No 7 151874022 151874022 G A nonsynonymous_SNV MLL3:NM_170606:exon38:c.C8516T:p.T2839I

MLL5 131 MSI-H III No 7 104752750 104752750 G T nonsynonymous_SNV MLL5:NM_018682:exon26:c.G4547T:p.G1516V

MSH6 131 MSI-H III No 2 48030609 48030609 T C nonsynonymous_SNV MSH6:NM_000179:exon5:c.T3223C:p.C1075R

MTR 131 MSI-H III No 1 237026799 237026799 G A nonsynonymous_SNV MTR:NM_000254:exon22:c.G2350A:p.V784M

MUSK 131 MSI-H III No 9 113538102 113538102 G A nonsynonymous_SNV MUSK:NM_001166281:exon8:c.G955A:p.A319T

PAK4 131 MSI-H III No 19 39667282 39667282 G A nonsynonymous_SNV PAK4:NM_001014834:exon6:c.G953A:p.R318Q

PIK3CA 131 MSI-H III No 3 178936092 178936092 A C nonsynonymous_SNV p.E545A

PIK3CA 131 MSI-H III No 3 178952006 178952006 T C nonsynonymous_SNV PIK3CA:NM_006218:exon21:c.T3061C:p.Y1021H

PIK3CD 131 MSI-H III No 1 9782042 9782042 C T synonymous_SNV PIK3CD:NM_005026:exon17:c.C2065T:p.L689L

PIK3CD 131 MSI-H III No 1 9775688 9775688 G A synonymous_SNV PIK3CD:NM_005026:exon4:c.G231A:p.A77A

PIK3R1 131 MSI-H III No 5 67589581 67589581 - A frameshift_insertion PIK3R1:NM_001242466:exon4:c.255dupA:p.K85fs

PLCB2 131 MSI-H III No 15 40591423 40591423 C T nonsynonymous_SNV PLCB2:NM_004573:exon8:c.G589A:p.A197T

PLCB4 131 MSI-H III No 20 9376193 9376193 A G nonsynonymous_SNV PLCB4:NM_000933:exon16:c.A1438G:p.M480V

PRKAA2 131 MSI-H III No 1 57157100 57157100 T - frameshift_deletion PRKAA2:NM_006252:exon3:c.270delT:p.F90fs

PRKDC 131 MSI-H III No 8 48866919 48866919 - T unknown UNKNOWN

PTK2B 131 MSI-H III No 8 27289876 27289876 C - frameshift_deletion PTK2B:NM_173175:exon10:c.985delC:p.Q329fs

PTPN14 131 MSI-H III No 1 214549683 214549683 G T nonsynonymous_SNV PTPN14:NM_005401:exon15:c.C2786A:p.A929D

PTPN5 131 MSI-H III No 11 18751292 18751292 G - frameshift_deletion PTPN5:NM_001039970:exon13:c.1307delC:p.A436fs

PTPRD 131 MSI-H III No 9 8340356 8340356 C T nonsynonymous_SNV PTPRD:NM_001171025:exon25:c.G4019A:p.R1340H

PTPRE 131 MSI-H III No 10 129839155 129839155 T C synonymous_SNV PTPRE:NM_006504:exon3:c.T10C:p.L4L

PTPRJ 131 MSI-H III No 11 48145202 48145202 G A synonymous_SNV PTPRJ:NM_001098503:exon5:c.G654A:p.T218T PTPRM 131 MSI-H III No 18 7955410 7955410 C A nonsynonymous_SNV PTPRM:NM_001105244:exon7:c.C1130A:p.A377D

PTPRS 131 MSI-H III No 19 5214414 5214414 G A synonymous_SNV PTPRS:NM_130853:exon21:c.C3231T:p.I1077I

RASGRF1 131 MSI-H III No 15 79298769 79298769 C T nonsynonymous_SNV RASGRF1:NM_001145648:exon14:c.G1834A:p.A612T

RBBP5 131 MSI-H III No 1 205069351 205069351 G A synonymous_SNV RBBP5:NM_001193272:exon7:c.C681T:p.G227G

RET 131 MSI-H III No 10 43622058 43622058 C G nonsynonymous_SNV RET:NM_020630:exon19:c.C3075G:p.D1025E

RYR3 131 MSI-H III No 15 34078185 34078185 T C splicing mutation RYR3(NM_001243996:exon66:c.9589+2T>C

SETD1B 131 MSI-H III No 12 122242665 122242665 - C frameshift_insertion SETD1B:NM_015048:exon1:c.22dupC:p.H8fs

SLC24A2 131 MSI-H III No 9 19516372 19516372 C T nonsynonymous_SNV SLC24A2:NM_001193288:exon9:c.G1714A:p.V572I

SLC25A31 131 MSI-H III No 4 128651925 128651925 C T synonymous_SNV SLC25A31:NM_031291:exon1:c.C225T:p.R75R

SLC8A2 131 MSI-H III No 19 47969575 47969575 G A nonsynonymous_SNV SLC8A2:NM_015063:exon2:c.C86T:p.P29L

STAT2 131 MSI-H III No 12 56744943 56744943 G A nonsynonymous_SNV STAT2:NM_005419:exon10:c.C973T:p.P325S

STAT5A 131 MSI-H III No 17 40459440 40459440 C T synonymous_SNV STAT5A:NM_003152:exon15:c.C1701T:p.N567N

STAT5A 131 MSI-H III No 17 40441516 40441516 G A synonymous_SNV STAT5A:NM_003152:exon3:c.G87A:p.E29E

TCF7L2 131 MSI-H III No 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TGFBR2 131 MSI-H III No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

TONSL 131 MSI-H III No 8 145663904 145663904 G A stopgain_SNV TONSL:NM_013432:exon13:c.C1603T:p.R535X

TRAF2 131 MSI-H III No 9 139793218 139793218 - C frameshift_insertion TRAF2:NM_021138:exon2:c.26dupC:p.P9fs

TSC1 131 MSI-H III No 9 135785988 135785988 G - frameshift_deletion TSC1:NM_001162427:exon11:c.1080delC:p.L360fs

APC 133 CIN III No 5 112175639 112175639 C T stopgain_SNV APC:NM_001127511:exon14:c.C4294T:p.R1432X

CACNA1A 133 CIN III No 19 13409985 13409985 C T nonsynonymous_SNV CACNA1A:NM_001127221:exon19:c.G2465A:p.R822Q

DNMT3B 133 CIN III No 20 31386387 31386387 C T nonsynonymous_SNV DNMT3B:NM_001207056:exon12:c.C1324T:p.R442C

DOCK3 133 CIN III No 3 51352542 51352542 A G nonsynonymous_SNV DOCK3:NM_004947:exon32:c.A3385G:p.N1129D

KRAS 133 CIN III No 12 25398281 25398281 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G38A:p.G13D

MLST8 133 CIN III No 16 2258840 2258840 G A nonsynonymous_SNV MLST8:NM_001199173:exon9:c.G943A:p.V315I

PIK3CA 133 CIN III No 3 178936091 178936091 G A nonsynonymous_SNV p.E545K

PTPRH 133 CIN III No 19 55711785 55711785 G C stopgain_SNV PTPRH:NM_001161440:exon5:c.C705G:p.Y235X

RYR1 133 CIN III No 19 38993303 38993303 C T nonsynonymous_SNV RYR1:NM_000540:exon48:c.C7771T:p.R2591W

TCF7L2 133 CIN III No 10 114710589 114710589 G - frameshift_deletion TCF7L2:NM_001146274:exon1:c.74delG:p.G25fs

TP53 133 CIN III No 17 7577520 7577520 A C nonsynonymous_SNV TP53:NM_001126115:exon3:c.T365G:p.I122S

TP53 133 CIN III No 17 7577500 7577500 T G nonsynonymous_SNV TP53:NM_001126115:exon3:c.A385C:p.S129R

AATK 135 MSI-H III No 17 79094874 79094874 C T synonymous_SNV AATK:NM_004920:exon10:c.G2553A:p.A851A

AATK 135 MSI-H III No 17 79095846 79095846 G A synonymous_SNV AATK:NM_004920:exon10:c.C1581T:p.G527G

ABL1 135 MSI-H III No 9 133761004 133761004 G A synonymous_SNV ABL1:NM_005157:exon11:c.G3327A:p.A1109A

ACVR2A 135 MSI-H III No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs AKAP11 135 MSI-H III No 13 42875105 42875105 G A synonymous_SNV AKAP11:NM_016248:exon8:c.G2223A:p.T741T

AKAP12 135 MSI-H III No 6 151670726 151670726 G A synonymous_SNV AKAP12:NM_144497:exon2:c.G906A:p.A302A

AKAP9 135 MSI-H III No 7 91691647 91691647 A - frameshift_deletion AKAP9:NM_005751:exon24:c.5824delA:p.T1942fs

AKAP9 135 MSI-H III No 7 91691785 91691785 G T nonsynonymous_SNV AKAP9:NM_005751:exon24:c.G5962T:p.G1988C

ALK 135 MSI-H III No 2 29443576 29443576 C T nonsynonymous_SNV ALK:NM_004304:exon23:c.G3641A:p.R1214H

AP4E1 135 MSI-H III No 15 51221333 51221333 G A nonsynonymous_SNV AP4E1:NM_001252127:exon6:c.G445A:p.A149T

APC2 135 MSI-H III No 19 1465602 1465602 G A nonsynonymous_SNV APC2:NM_005883:exon15:c.G2302A:p.A768T

ARID1A 135 MSI-H III No 1 27088786 27088786 - C frameshift_insertion ARID1A:NM_006015:exon7:c.2395dupC:p.Q799fs

ARID2 135 MSI-H III No 12 46246052 46246052 C T synonymous_SNV ARID2:NM_152641:exon15:c.C4146T:p.S1382S

ATP2A1 135 MSI-H III No 16 28914746 28914746 C T nonsynonymous_SNV ATP2A1:NM_004320:exon21:c.C2965T:p.R989W

ATP2A3 135 MSI-H III No 17 3851060 3851060 C T synonymous_SNV ATP2A3:NM_005173:exon8:c.G720A:p.A240A

ATP2B2 135 MSI-H III No 3 10401790 10401790 G A synonymous_SNV ATP2B2:NM_001683:exon10:c.C1542T:p.G514G

ATP2B3 135 MSI-H III No X 152825399 152825399 C T synonymous_SNV ATP2B3:NM_001001344:exon16:c.C2838T:p.V946V

ATR 135 MSI-H III No 3 142274749 142274749 T - frameshift_deletion ATR:NM_001184:exon10:c.2311delA:p.K771fs

ATRX 135 MSI-H III No X 76939680 76939680 T - frameshift_deletion ATRX:NM_138270:exon8:c.954delA:p.A318fs

BRAF 135 MSI-H III No 7 140494118 140494118 A G nonsynonymous_SNV BRAF:NM_004333:exon8:c.T1130C:p.V377A

CACNA1A 135 MSI-H III No 19 13319687 13319687 C T synonymous_SNV CACNA1A:NM_001127221:exon46:c.G6666A:p.P2222P

CACNA1B 135 MSI-H III No 9 140901276 140901276 G A nonsynonymous_SNV CACNA1B:NM_000718:exon16:c.G2032A:p.G678S

CACNA1C 135 MSI-H III No 12 2788856 2788856 C T nonsynonymous_SNV CACNA1C:NM_001129837:exon41:c.C5362T:p.R1788C

CACNA1H 135 MSI-H III No 16 1268999 1268999 G A nonsynonymous_SNV CACNA1H:NM_001005407:exon33:c.G5899A:p.A1967T

CACNA1I 135 MSI-H III No 22 40060801 40060801 G A nonsynonymous_SNV CACNA1I:NM_001003406:exon20:c.G3619A:p.V1207M

CACNA1I 135 MSI-H III No 22 40076937 40076937 G T synonymous_SNV CACNA1I:NM_001003406:exon33:c.G5439T:p.V1813V

CACNA2D1 135 MSI-H III No 7 81964475 81964475 C T synonymous_SNV CACNA2D1:NM_000722:exon3:c.G270A:p.L90L

CACNG3 135 MSI-H III No 16 24372750 24372750 A - frameshift_deletion CACNG3:NM_006539:exon4:c.514delA:p.S172fs

CBL 135 MSI-H III No 11 119103189 119103189 C T nonsynonymous_SNV CBL:NM_005188:exon2:c.C227T:p.A76V

CBS 135 MSI-H III No 21 44486375 44486375 G A synonymous_SNV CBS:NM_000071:exon5:c.C429T:p.I143I

CDKN1A 135 MSI-H III No 6 36652305 36652305 C T nonsynonymous_SNV CDKN1A:NM_000389:exon2:c.C427T:p.R143W

CHD2 135 MSI-H III No 15 93567865 93567865 G A nonsynonymous_SNV CHD2:NM_001271:exon39:c.G5417A:p.R1806K

CHD2 135 MSI-H III No 15 93482898 93482898 T C synonymous_SNV CHD2:NM_001042572:exon7:c.T642C:p.D214D

CHD3 135 MSI-H III No 17 7794007 7794007 A - frameshift_deletion CHD3:NM_001005271:exon3:c.509delA:p.K170fs

CHD4 135 MSI-H III No 12 6692526 6692526 G A nonsynonymous_SNV CHD4:NM_001273:exon26:c.C3898T:p.R1300W

CHD5 135 MSI-H III No 1 6166468 6166468 C T synonymous_SNV CHD5:NM_015557:exon40:c.G5844A:p.G1948G

CREBBP 135 MSI-H III No 16 3778038 3778038 G A nonsynonymous_SNV CREBBP:NM_001079846:exon30:c.C6896T:p.T2299M

CRTC2 135 MSI-H III No 1 153924678 153924678 - C frameshift_insertion CRTC2:NM_181715:exon10:c.813dupG:p.T271fs CTNNA1 135 MSI-H III No 5 138253520 138253520 A - frameshift_deletion CTNNA1:NM_001903:exon11:c.1479delA:p.K493fs

CTNNA1 135 MSI-H III No 5 138266342 138266342 C T stopgain_SNV CTNNA1:NM_001903:exon15:c.C2191T:p.R731X

CTNNA2 135 MSI-H III No 2 80136890 80136890 G A synonymous_SNV CTNNA2:NM_001164883:exon7:c.G1023A:p.A341A

DAZAP2 135 MSI-H III No 12 51639923 51639923 A G nonsynonymous_SNV DAZAP2:NM_001136269:exon4:c.A457G:p.M153V

DDR1 135 MSI-H III No 6 30856773 30856773 C T synonymous_SNV DDR1:NM_001202521:exon2:c.C174T:p.A58A

DNAH3 135 MSI-H III No 16 20999298 20999298 G A nonsynonymous_SNV DNAH3:NM_017539:exon45:c.C6691T:p.H2231Y

DNAH3 135 MSI-H III No 16 20996704 20996704 C T nonsynonymous_SNV DNAH3:NM_017539:exon48:c.G7360A:p.E2454K

DNAH3 135 MSI-H III No 16 21011751 21011751 G A synonymous_SNV DNAH3:NM_017539:exon43:c.C6216T:p.F2072F

DNAH3 135 MSI-H III No 16 21049104 21049104 C T synonymous_SNV DNAH3:NM_017539:exon34:c.G4929A:p.A1643A

DNMT3B 135 MSI-H III No 20 31388077 31388077 C T synonymous_SNV DNMT3B:NM_001207056:exon14:c.C1590T:p.N530N

DOCK3 135 MSI-H III No 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

DPF3 135 MSI-H III No 14 73220023 73220023 G A stopgain_SNV DPF3:NM_012074:exon3:c.C250T:p.R84X

DPYD 135 MSI-H III No 1 98058936 98058936 G A synonymous_SNV DPYD:NM_000110:exon10:c.C966T:p.C322C

DVL2 135 MSI-H III No 17 7131055 7131055 C T nonsynonymous_SNV DVL2:NM_004422:exon11:c.G1150A:p.A384T

EIF4B 135 MSI-H III No 12 53427598 53427598 C - frameshift_deletion EIF4B:NM_001417:exon9:c.988delC:p.Q330fs

EIF4B 135 MSI-H III No 12 53433955 53433956 CT - frameshift_deletion EIF4B:NM_001417:exon15:c.1784_1785del:p.595_595del

EP400 135 MSI-H III No 12 132547094 132547096 CAG - nonframeshift_deletion EP400:NM_015409:exon47:c.8182_8184del:p.2728_2728del

EPHB1 135 MSI-H III No 3 134851762 134851762 C T nonsynonymous_SNV EPHB1:NM_004441:exon5:c.C1168T:p.R390C

EPHB6 135 MSI-H III No 7 142568117 142568117 C T nonsynonymous_SNV EPHB6:NM_004445:exon18:c.C2758T:p.R920C

EPHB6 135 MSI-H III No 7 142563350 142563350 G A nonsynonymous_SNV EPHB6:NM_004445:exon8:c.G1067A:p.R356Q

EPHB6 135 MSI-H III No 7 142567565 142567565 - C splicing mutation EPHB6(NM_004445:exon17:c.2458-5->C)

FGFR1 135 MSI-H III No 8 38275752 38275752 C T nonsynonymous_SNV FGFR1:NM_001174066:exon9:c.G1157A:p.R386Q

FGFR3 135 MSI-H III No 4 1801060 1801060 G A synonymous_SNV FGFR3:NM_000142:exon3:c.G189A:p.P63P

FLT4 135 MSI-H III No 5 180050992 180050992 G T synonymous_SNV FLT4:NM_002020:exon11:c.C1491A:p.A497A

FTCD 135 MSI-H III No 21 47574183 47574183 C T nonsynonymous_SNV FTCD:NM_006657:exon2:c.G118A:p.A40T

FTCD 135 MSI-H III No 21 47565421 47565421 C T synonymous_SNV FTCD:NM_006657:exon10:c.G1170A:p.T390T

GNA11 135 MSI-H III No 19 3121008 3121008 C T nonsynonymous_SNV GNA11:NM_002067:exon7:c.C911T:p.A304V

GNAS 135 MSI-H III No 20 57415360 57415360 G A nonsynonymous_SNV GNAS:NM_016592:exon1:c.G199A:p.A67T

GRIN1 135 MSI-H III No 9 140061881 140061881 G T nonsynonymous_SNV GRIN1:NM_021569:exon19:c.G2608T:p.G870C

HCFC1 135 MSI-H III No X 153227011 153227011 G A synonymous_SNV HCFC1:NM_005334:exon6:c.C886T:p.L296L

HDAC2 135 MSI-H III No 6 114292048 114292048 T - frameshift_deletion HDAC2:NM_001527:exon1:c.25delA:p.K9fs

HDAC6 135 MSI-H III No X 48681638 48681638 C T synonymous_SNV HDAC6:NM_006044:exon25:c.C2829T:p.V943V

HDAC7 135 MSI-H III No 12 48189051 48189051 C T synonymous_SNV HDAC7:NM_001098416:exon10:c.G1089A:p.L363L

HDAC9 135 MSI-H III No 7 18788665 18788665 C T synonymous_SNV HDAC9:NM_058176:exon13:c.C1938T:p.C646C INSR 135 MSI-H III No 19 7117121 7117121 G A synonymous_SNV INSR:NM_001079817:exon21:c.C4059T:p.N1353N

INSRR 135 MSI-H III No 1 156814902 156814902 G A synonymous_SNV INSRR:NM_014215:exon12:c.C2403T:p.A801A

IRS1 135 MSI-H III No 2 227661671 227661671 C - frameshift_deletion IRS1:NM_005544:exon1:c.1784delG:p.R595fs

IRS1 135 MSI-H III No 2 227662124 227662124 C G nonsynonymous_SNV IRS1:NM_005544:exon1:c.G1331C:p.S444T

ITPR1 135 MSI-H III No 3 4709183 4709183 G A synonymous_SNV ITPR1:NM_001168272:exon17:c.G1791A:p.A597A

ITPR3 135 MSI-H III No 6 33653962 33653962 G A nonsynonymous_SNV ITPR3:NM_002224:exon42:c.G5800A:p.V1934M

JMJD1C 135 MSI-H III No 10 64974606 64974606 T - frameshift_deletion JMJD1C:NM_004241:exon5:c.664delA:p.K222fs

JMJD1C 135 MSI-H III No 10 64974395 64974395 T G nonsynonymous_SNV JMJD1C:NM_004241:exon5:c.A875C:p.D292A

KAT2A 135 MSI-H III No 17 40266956 40266956 C T nonsynonymous_SNV KAT2A:NM_021078:exon13:c.G1973A:p.R658H

KAT2A 135 MSI-H III No 17 40267771 40267771 G A synonymous_SNV KAT2A:NM_021078:exon12:c.C1845T:p.D615D

KDM6B 135 MSI-H III No 17 7756403 7756403 C T nonsynonymous_SNV KDM6B:NM_001080424:exon21:c.C4696T:p.R1566C

KDM6B 135 MSI-H III No 17 7751854 7751854 G A nonsynonymous_SNV KDM6B:NM_001080424:exon11:c.G2248A:p.A750T

LCK 135 MSI-H III No 1 32741597 32741597 C T synonymous_SNV LCK:NM_001042771:exon7:c.C564T:p.N188N

LEF1 135 MSI-H III No 4 109000650 109000650 G A synonymous_SNV LEF1:NM_001130713:exon6:c.C759T:p.H253H

LTK 135 MSI-H III No 15 41797479 41797479 G A nonsynonymous_SNV LTK:NM_001135685:exon13:c.C1462T:p.R488W

MAP2K2 135 MSI-H III No 19 4094469 4094469 C T synonymous_SNV MAP2K2:NM_030662:exon10:c.G1074A:p.A358A

MAP3K1 135 MSI-H III No 5 56168713 56168713 G A nonsynonymous_SNV MAP3K1:NM_005921:exon9:c.G1567A:p.V523I

MAPK15 135 MSI-H III No 8 144803822 144803822 G A synonymous_SNV MAPK15:NM_139021:exon12:c.G1308A:p.A436A

MAPK4 135 MSI-H III No 18 48255940 48255940 G A nonsynonymous_SNV MAPK4:NM_002747:exon6:c.G1480A:p.A494T

MAPK7 135 MSI-H III No 17 19283132 19283132 C T synonymous_SNV MAPK7:NM_002749:exon3:c.C270T:p.F90F

MAPK8IP2 135 MSI-H III No 22 51042980 51042980 C T unknown UNKNOWN

MAPK8IP2 135 MSI-H III No 22 51042385 51042385 G - unknown UNKNOWN

MAPK8IP3 135 MSI-H III No 16 1816530 1816530 C T synonymous_SNV MAPK8IP3:NM_001040439:exon22:c.C2799T:p.S933S

MAPKBP1 135 MSI-H III No 15 42115704 42115704 G A nonsynonymous_SNV MAPKBP1:NM_014994:exon29:c.G3658A:p.E1220K

MATK 135 MSI-H III No 19 3781669 3781669 C T synonymous_SNV MATK:NM_139354:exon7:c.G555A:p.A185A

MERTK 135 MSI-H III No 2 112686781 112686781 C T nonsynonymous_SNV MERTK:NM_006343:exon2:c.C146T:p.P49L

MLH1 135 MSI-H III No 3 37070427 37070427 C T splicing mutation MLH1(NM_001258271:exon13:c.1558+4C>T

MLL2 135 MSI-H III No 12 49447923 49447923 G A nonsynonymous_SNV MLL2:NM_003482:exon5:c.C511T:p.R171C

MLL2 135 MSI-H III No 12 49418362 49418362 G A nonsynonymous_SNV MLL2:NM_003482:exon50:c.C16051T:p.R5351W

MLL3 135 MSI-H III No 7 151845529 151845529 A - frameshift_deletion MLL3:NM_170606:exon52:c.13483delT:p.F4495fs

MLL3 135 MSI-H III No 7 151873308 151873308 C T nonsynonymous_SNV MLL3:NM_170606:exon38:c.G9230A:p.R3077H

MLL4 135 MSI-H III No 19 36214094 36214094 C T nonsynonymous_SNV MLL4:NM_014727:exon6:c.C2920T:p.R974C

MLL4 135 MSI-H III No 19 36218461 36218461 C T nonsynonymous_SNV MLL4:NM_014727:exon16:c.C4240T:p.R1414C

MLL4 135 MSI-H III No 19 36212415 36212415 C T synonymous_SNV MLL4:NM_014727:exon3:c.C2166T:p.H722H MSH2 135 MSI-H III No 2 47656999 47656999 G A nonsynonymous_SNV MSH2:NM_000251:exon7:c.G1195A:p.A399T

MTHFD1 135 MSI-H III No 14 64891572 64891572 G A nonsynonymous_SNV MTHFD1:NM_005956:exon9:c.G778A:p.E260K

P2RX1 135 MSI-H III No 17 3802253 3802253 C T nonsynonymous_SNV P2RX1:NM_002558:exon9:c.G941A:p.R314H

PDK2 135 MSI-H III No 17 48183476 48183476 G - frameshift_deletion PDK2:NM_001199900:exon4:c.560delG:p.G187fs

PIK3C2B 135 MSI-H III No 1 204438090 204438090 G - frameshift_deletion PIK3C2B:NM_002646:exon3:c.841delC:p.P281fs

PIK3C2B 135 MSI-H III No 1 204425098 204425098 G A nonsynonymous_SNV PIK3C2B:NM_002646:exon12:c.C1829T:p.T610M

PIK3CD 135 MSI-H III No 1 9781296 9781296 C T nonsynonymous_SNV PIK3CD:NM_005026:exon14:c.C1801T:p.R601W

PIK3CG 135 MSI-H III No 7 106508673 106508673 G A nonsynonymous_SNV PIK3CG:NM_002649:exon2:c.G667A:p.V223I

PIK3CG 135 MSI-H III No 7 106508826 106508826 G A nonsynonymous_SNV PIK3CG:NM_002649:exon2:c.G820A:p.V274I

PIK3R5 135 MSI-H III No 17 8789549 8789549 A T nonsynonymous_SNV PIK3R5:NM_001251852:exon13:c.T967A:p.S323T

PLCB1 135 MSI-H III No 20 8745983 8745983 G A nonsynonymous_SNV PLCB1:NM_015192:exon26:c.G2908A:p.A970T

PLCB1 135 MSI-H III No 20 8755189 8755189 G A synonymous_SNV PLCB1:NM_015192:exon27:c.G2934A:p.S978S

PLCB3 135 MSI-H III No 11 64034998 64034998 G A synonymous_SNV PLCB3:NM_001184883:exon29:c.G3474A:p.S1158S

PLCE1 135 MSI-H III No 10 96058261 96058261 G A nonsynonymous_SNV PLCE1:NM_001165979:exon23:c.G4369A:p.A1457T

PTK6 135 MSI-H III No 20 62161538 62161538 G A nonsynonymous_SNV PTK6:NM_005975:exon7:c.C1061T:p.T354M

PTPN1 135 MSI-H III No 20 49181518 49181518 G A nonsynonymous_SNV PTPN1:NM_002827:exon3:c.G167A:p.R56Q

PTPN23 135 MSI-H III No 3 47452328 47452328 C - frameshift_deletion PTPN23:NM_015466:exon20:c.3040delC:p.L1014fs

PTPN5 135 MSI-H III No 11 18787417 18787418 TC - frameshift_deletion PTPN5:NM_001039970:exon3:c.33_34del:p.11_12del

PTPRB 135 MSI-H III No 12 70974997 70974997 G A synonymous_SNV PTPRB:NM_001206971:exon7:c.C1473T:p.D491D

PTPRF 135 MSI-H III No 1 44054410 44054410 G A nonsynonymous_SNV PTPRF:NM_002840:exon8:c.G688A:p.V230M

PTPRF 135 MSI-H III No 1 44057004 44057004 C T synonymous_SNV PTPRF:NM_002840:exon9:c.C1311T:p.P437P

PTPRH 135 MSI-H III No 19 55693505 55693505 C T nonsynonymous_SNV PTPRH:NM_001161440:exon17:c.G2543A:p.R848H

PTPRH 135 MSI-H III No 19 55698911 55698911 C T nonsynonymous_SNV PTPRH:NM_001161440:exon12:c.G2002A:p.A668T

PTPRO 135 MSI-H III No 12 15739975 15739975 A G nonsynonymous_SNV PTPRO:NM_030668:exon11:c.A883G:p.I295V

PTPRT 135 MSI-H III No 20 40709541 40709541 A T nonsynonymous_SNV PTPRT:NM_007050:exon31:c.T4304A:p.L1435Q

PTPRZ1 135 MSI-H III No 7 121650804 121650804 T C synonymous_SNV PTPRZ1:NM_001206838:exon12:c.T1704C:p.Y568Y

RASA1 135 MSI-H III No 5 86672330 86672330 G A nonsynonymous_SNV RASA1:NM_002890:exon16:c.G2132A:p.R711Q

RASGRF2 135 MSI-H III No 5 80375935 80375935 - T splicing mutation RASGRF2(NM_006909:exon6:c.888-5->T)

RASGRP3 135 MSI-H III No 2 33748980 33748980 G A nonsynonymous_SNV RASGRP3:NM_015376:exon7:c.G551A:p.C184Y

RASGRP4 135 MSI-H III No 19 38912655 38912655 G A synonymous_SNV RASGRP4:NM_001146202:exon2:c.C162T:p.G54G

RET 135 MSI-H III No 10 43622099 43622099 C T nonsynonymous_SNV RET:NM_020630:exon19:c.C3116T:p.P1039L

RGS4 135 MSI-H III No 1 163044148 163044148 G A nonsynonymous_SNV RGS4:NM_001113380:exon5:c.G362A:p.R121Q

RPS6KB2 135 MSI-H III No 11 67202561 67202561 C T nonsynonymous_SNV RPS6KB2:NM_003952:exon15:c.C1370T:p.S457L

RYR1 135 MSI-H III No 19 38976670 38976670 C T nonsynonymous_SNV RYR1:NM_000540:exon34:c.C5375T:p.A1792V RYR1 135 MSI-H III No 19 39001200 39001200 G A nonsynonymous_SNV RYR1:NM_000540:exon59:c.G8995A:p.A2999T

RYR1 135 MSI-H III No 19 38985155 38985155 G A synonymous_SNV RYR1:NM_000540:exon39:c.G6438A:p.P2146P

RYR1 135 MSI-H III No 19 38976416 38976416 C T synonymous_SNV RYR1:NM_000540:exon34:c.C5121T:p.R1707R

RYR1 135 MSI-H III No 19 39063948 39063948 G A splicing mutation RYR1(NM_001042723:exon95:c.14114+1G>A

RYR3 135 MSI-H III No 15 34021073 34021073 A G nonsynonymous_SNV RYR3:NM_001036:exon47:c.A7049G:p.E2350G

SETD1A 135 MSI-H III No 16 30976167 30976167 G A synonymous_SNV SETD1A:NM_014712:exon7:c.G1104A:p.A368A

SETD1B 135 MSI-H III No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SETD1B 135 MSI-H III No 12 122257572 122257572 G A synonymous_SNV SETD1B:NM_015048:exon11:c.G3552A:p.S1184S

SLC24A1 135 MSI-H III No 15 65946376 65946376 A G nonsynonymous_SNV SLC24A1:NM_001254740:exon7:c.A1240G:p.M414V

SMAD9 135 MSI-H III No 13 37453641 37453641 C T synonymous_SNV SMAD9:NM_001127217:exon2:c.G186A:p.P62P

SMARCA4 135 MSI-H III No 19 11145693 11145693 C T nonsynonymous_SNV SMARCA4:NM_001128845:exon27:c.C3956T:p.A1319V

SMARCA4 135 MSI-H III No 19 11143976 11143976 C T nonsynonymous_SNV SMARCA4:NM_001128845:exon25:c.C3557T:p.A1186V

SMARCB1 135 MSI-H III No 22 24175760 24175760 G A nonsynonymous_SNV SMARCB1:NM_001007468:exon8:c.G961A:p.E321K

SMURF2 135 MSI-H III No 17 62579580 62579580 G A stopgain_SNV SMURF2:NM_022739:exon7:c.C568T:p.R190X

SND1 135 MSI-H III No 7 127721535 127721535 G A nonsynonymous_SNV SND1:NM_014390:exon18:c.G2092A:p.V698M

SND1 135 MSI-H III No 7 127732089 127732089 C T synonymous_SNV SND1:NM_014390:exon24:c.C2712T:p.D904D

SOCS3 135 MSI-H III No 17 76354582 76354582 C T nonsynonymous_SNV SOCS3:NM_003955:exon2:c.G595A:p.G199S

SOCS3 135 MSI-H III No 17 76355147 76355147 G A synonymous_SNV SOCS3:NM_003955:exon2:c.C30T:p.A10A

SRM 135 MSI-H III No 1 11116694 11116694 C T nonsynonymous_SNV SRM:NM_003132:exon4:c.G502A:p.D168N

STAT5A 135 MSI-H III No 17 40459688 40459688 G A nonsynonymous_SNV STAT5A:NM_003152:exon16:c.G1853A:p.R618H

STAT5B 135 MSI-H III No 17 40362453 40362453 T - frameshift_deletion STAT5B:NM_012448:exon14:c.1743delA:p.L581fs

STPG2 135 MSI-H III No 4 98762004 98762004 C T nonsynonymous_SNV STPG2:NM_174952:exon9:c.G1124A:p.R375H

TCF7L1 135 MSI-H III No 2 85529625 85529625 G A nonsynonymous_SNV TCF7L1:NM_031283:exon5:c.G544A:p.V182I

TCF7L1 135 MSI-H III No 2 85533436 85533436 C T nonsynonymous_SNV TCF7L1:NM_031283:exon9:c.C1097T:p.A366V

TDG 135 MSI-H III No 12 104374670 104374670 G T splicing mutation TDG(NM_003211:exon4:c.409-1G>T)

TGFBR2 135 MSI-H III No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

TNK2 135 MSI-H III No 3 195595236 195595236 - G frameshift_insertion TNK2:NM_005781:exon12:c.1888dupC:p.P630fs

TP53 135 MSI-H III No 17 7578389 7578389 G A nonsynonymous_SNV TP53:NM_001126115:exon1:c.C145T:p.R49C

TP53 135 MSI-H III No 17 7578456 7578456 G A synonymous_SNV TP53:NM_001126115:exon1:c.C78T:p.R26R

TRDN 135 MSI-H III No 6 123786042 123786042 A - frameshift_deletion TRDN:NM_001256020:exon9:c.880delT:p.F294fs

TRRAP 135 MSI-H III No 7 98557071 98557071 C T synonymous_SNV TRRAP:NM_003496:exon43:c.C6372T:p.S2124S

TRRAP 135 MSI-H III No 7 98602859 98602859 C T synonymous_SNV TRRAP:NM_003496:exon67:c.C10512T:p.D3504D

TSC1 135 MSI-H III No 9 135771992 135771992 C T nonsynonymous_SNV TSC1:NM_001162427:exon22:c.G2972A:p.S991N

TSC2 135 MSI-H III No 16 2126525 2126525 G T nonsynonymous_SNV TSC2:NM_000548:exon25:c.G2776T:p.D926Y TXK 135 MSI-H III No 4 48088567 48088567 C T nonsynonymous_SNV TXK:NM_003328:exon10:c.G872A:p.R291Q

UCK2 135 MSI-H III No 1 165877003 165877003 C T synonymous_SNV UCK2:NM_012474:exon7:c.C729T:p.N243N

ULK1 135 MSI-H III No 12 132394809 132394809 T - frameshift_deletion ULK1:NM_003565:exon11:c.819delT:p.F273fs

ULK1 135 MSI-H III No 12 132402072 132402072 C - frameshift_deletion ULK1:NM_003565:exon22:c.2299delC:p.Q767fs

ULK1 135 MSI-H III No 12 132393332 132393332 G A nonsynonymous_SNV ULK1:NM_003565:exon6:c.G460A:p.A154T

ZNF521 135 MSI-H III No 18 22805158 22805158 G A synonymous_SNV ZNF521:NM_015461:exon4:c.C2724T:p.D908D

APC 137 CIN III Yes 5 112174622 112174622 G T stopgain_SNV APC:NM_001127511:exon14:c.G3277T:p.E1093X

ATM 137 CIN III Yes 11 108202221 108202221 A G synonymous_SNV ATM:NM_000051:exon51:c.A7566G:p.Q2522Q

DDR1 137 CIN III Yes 6 30856567 30856567 G A nonsynonymous_SNV DDR1:NM_001202521:exon1:c.G61A:p.D21N

EPHA5 137 CIN III Yes 4 66361132 66361132 G C nonsynonymous_SNV EPHA5:NM_004439:exon4:c.C1040G:p.S347C

FBXW7 137 CIN III Yes 4 153247289 153247289 G A nonsynonymous_SNV FBXW7:NM_001013415:exon9:c.C1159T:p.R387C

HDAC9 137 CIN III Yes 7 18914211 18914211 C T nonsynonymous_SNV HDAC9:NM_058176:exon21:c.C2786T:p.T929M

KAT6B 137 CIN III Yes 10 76789551 76789551 G T nonsynonymous_SNV KAT6B:NM_001256468:exon18:c.G4420T:p.D1474Y

PTPRA 137 CIN III Yes 20 2945842 2945842 C A nonsynonymous_SNV PTPRA:NM_080840:exon5:c.C409A:p.P137T

SMARCD1 137 CIN III Yes 12 50482376 50482376 G T stopgain_SNV SMARCD1:NM_003076:exon6:c.G727T:p.E243X

TP53 137 CIN III Yes 17 7579325 7579325 - ACTT stopgain_SNV TP53:NM_001126118:exon3:c.244_245insAAGT:p.S82_V83delinsX

APC 139 CIN III Yes 5 112155044 112155044 A C splicing mutation APC(NM_001127511:exon8:c.1258+3A>C

CTNND1 139 CIN III Yes 11 57564127 57564127 C - frameshift_deletion CTNND1:NM_001085469:exon3:c.316delC:p.H106fs

EPHA5 139 CIN III Yes 4 66467645 66467645 C A nonsynonymous_SNV EPHA5:NM_004439:exon3:c.G624T:p.K208N

EPHB6 139 CIN III Yes 7 142566076 142566076 G A nonsynonymous_SNV EPHB6:NM_004445:exon14:c.G1996A:p.D666N

GGH 139 CIN III Yes 8 63951267 63951267 G A nonsynonymous_SNV GGH:NM_003878:exon1:c.C61T:p.L21F

ITPR1 139 CIN III Yes 3 4562744 4562744 C T synonymous_SNV ITPR1:NM_001099952:exon4:c.C129T:p.T43T

KRAS 139 CIN III Yes 12 25398284 25398284 C A nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35T:p.G12V

NTRK3 139 CIN III Yes 15 88680782 88680782 G T nonsynonymous_SNV NTRK3:NM_001007156:exon7:c.C475A:p.Q159K

PTPRS 139 CIN III Yes 19 5273535 5273535 C T synonymous_SNV PTPRS:NM_002850:exon4:c.G297A:p.P99P

PTPRT 139 CIN III Yes 20 40735471 40735471 G A synonymous_SNV PTPRT:NM_007050:exon24:c.C3345T:p.C1115C

RYR1 139 CIN III Yes 19 38976315 38976315 G T nonsynonymous_SNV RYR1:NM_000540:exon34:c.G5020T:p.A1674S

AKAP1 141 CIN IV Yes, at diagnosis 17 55184336 55184336 C G nonsynonymous_SNV AKAP1:NM_003488:exon2:c.C1511G:p.P504R

AKAP13 141 CIN IV Yes, at diagnosis 15 86198874 86198874 A T nonsynonymous_SNV AKAP13:NM_001270546:exon4:c.A521T:p.E174V

ALK 141 CIN IV Yes, at diagnosis 2 30143332 30143332 C T nonsynonymous_SNV ALK:NM_004304:exon1:c.G194A:p.R65H

APC 141 CIN IV Yes, at diagnosis 5 112175957 112175957 - A frameshift_insertion APC:NM_001127511:exon14:c.4612dupA:p.T1538fs

ATP2B2 141 CIN IV Yes, at diagnosis 3 10491156 10491156 G A synonymous_SNV ATP2B2:NM_001001331:exon2:c.C72T:p.F24F

BRAF 141 CIN IV Yes, at diagnosis 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CTNND2 141 CIN IV Yes, at diagnosis 5 10988330 10988330 T C nonsynonymous_SNV CTNND2:NM_001332:exon20:c.A3236G:p.E1079G CTNND2 141 CIN IV Yes, at diagnosis 5 11385297 11385297 C T synonymous_SNV CTNND2:NM_001332:exon7:c.G657A:p.A219A

EPHA5 141 CIN IV Yes, at diagnosis 4 66535320 66535320 G A synonymous_SNV EPHA5:NM_004439:exon1:c.C141T:p.C47C

KAT2B 141 CIN IV Yes, at diagnosis 3 20161118 20161118 - G frameshift_insertion KAT2B:NM_003884:exon8:c.1179_1180insG:p.T393fs

MAPK4 141 CIN IV Yes, at diagnosis 18 48256053 48256053 C T synonymous_SNV MAPK4:NM_002747:exon6:c.C1593T:p.G531G

MAPK9 141 CIN IV Yes, at diagnosis 5 179669664 179669664 G A synonymous_SNV MAPK9:NM_002752:exon8:c.C780T:p.V260V

MTOR 141 CIN IV Yes, at diagnosis 1 11190804 11190804 C T nonsynonymous_SNV MTOR:NM_004958:exon39:c.G5395A:p.E1799K

NR4A1 141 CIN IV Yes, at diagnosis 12 52452558 52452558 G A nonsynonymous_SNV NR4A1:NM_173157:exon7:c.G1627A:p.A543T

PRKAR2B 141 CIN IV Yes, at diagnosis 7 106799999 106799999 A G nonsynonymous_SNV PRKAR2B:NM_002736:exon11:c.A1229G:p.N410S

RASGRP2 141 CIN IV Yes, at diagnosis 11 64502632 64502632 C T nonsynonymous_SNV RASGRP2:NM_001098670:exon12:c.G1364A:p.R455H

TP53 141 CIN IV Yes, at diagnosis 17 7577560 7577560 A C nonsynonymous_SNV TP53:NM_001126115:exon3:c.T325G:p.S109A

AKAP12 143 CIN III Yes 6 151674116 151674116 - GA frameshift_insertion AKAP12:NM_144497:exon2:c.4296_4297insGA:p.I1432fs

AKAP12 143 CIN III Yes 6 151674117 151674117 - G frameshift_insertion AKAP12:NM_144497:exon2:c.4297dupG:p.E1433fs

AKT2 143 CIN III Yes 19 40771137 40771137 T C nonsynonymous_SNV AKT2:NM_001626:exon2:c.A38G:p.H13R

BAZ2B 143 CIN III Yes 2 160242861 160242861 - T splicing mutation BAZ2B(NM_013450:exon23:c.3471+3->A)

CACNA1A 143 CIN III Yes 19 13318673 13318675 CTG - nonframeshift_deletion CACNA1A:NM_001127222:exon47:c.6973_6975del:p.2325_2325del

GRB2 143 CIN III Yes 17 73316492 73316492 A T nonsynonymous_SNV GRB2:NM_203506:exon5:c.T488A:p.M163K

MAPK8IP2 143 CIN III Yes 22 51043071 51043071 G A unknown UNKNOWN

MTHFD1 143 CIN III Yes 14 64892880 64892880 G A nonsynonymous_SNV MTHFD1:NM_005956:exon11:c.G1097A:p.R366Q

PRKD1 143 CIN III Yes 14 30396590 30396590 C T synonymous_SNV PRKD1:NM_002742:exon1:c.G129A:p.A43A

RASGRF1 143 CIN III Yes 15 79324525 79324525 C A nonsynonymous_SNV RASGRF1:NM_001145648:exon7:c.G1092T:p.E364D

SLC4A4 143 CIN III Yes 4 72306363 72306363 C T nonsynonymous_SNV SLC4A4:NM_003759:exon5:c.C706T:p.R236C

SMAD4 143 CIN III Yes 18 48591904 48591904 C G nonsynonymous_SNV SMAD4:NM_005359:exon9:c.C1067G:p.P356R

TNK2 143 CIN III Yes 3 195611725 195611725 G A synonymous_SNV TNK2:NM_001010938:exon4:c.C603T:p.G201G

TP53 143 CIN III Yes 17 7578190 7578190 T C nonsynonymous_SNV TP53:NM_001126115:exon2:c.A263G:p.Y88C

AATK 145 CIN III Yes 17 79096551 79096551 C A synonymous_SNV AATK:NM_004920:exon10:c.G876T:p.L292L

ATM 145 CIN III Yes 11 108214042 108214042 C T nonsynonymous_SNV ATM:NM_000051:exon57:c.C8362T:p.H2788Y

CACNA1D 145 CIN III Yes 3 53810972 53810972 G T nonsynonymous_SNV CACNA1D:NM_001128839:exon36:c.G4531T:p.V1511L

CAMK2G 145 CIN III Yes 10 75581436 75581436 C A splicing mutation CAMK2G(NM_001222:exon16:c.1084+4G>T

CDH20 145 CIN III Yes 18 59166523 59166523 C T synonymous_SNV CDH20:NM_031891:exon2:c.C351T:p.H117H

CHD6 145 CIN III Yes 20 40085924 40085924 G A stopgain_SNV CHD6:NM_032221:exon18:c.C2809T:p.R937X

CHD7 145 CIN III Yes 8 61769310 61769310 C T nonsynonymous_SNV CHD7:NM_017780:exon34:c.C7471T:p.R2491C

CREBBP 145 CIN III Yes 16 3817860 3817860 G T nonsynonymous_SNV CREBBP:NM_001079846:exon15:c.C2997A:p.D999E

DOCK3 145 CIN III Yes 3 51393525 51393525 C - frameshift_deletion DOCK3:NM_004947:exon42:c.4255delC:p.Q1419fs

EPHB2 145 CIN III Yes 1 23111223 23111223 C T synonymous_SNV EPHB2:NM_004442:exon3:c.C465T:p.R155R ERBB3 145 CIN III Yes 12 56481660 56481660 C T nonsynonymous_SNV ERBB3:NM_001982:exon6:c.C695T:p.A232V

GNAL 145 CIN III Yes 18 11872276 11872276 G T synonymous_SNV GNAL:NM_001261444:exon6:c.G189T:p.R63R

HCFC1 145 CIN III Yes X 153225489 153225489 G T nonsynonymous_SNV HCFC1:NM_005334:exon8:c.C1208A:p.P403H

HDAC10 145 CIN III Yes 22 50684361 50684361 C A nonsynonymous_SNV HDAC10:NM_001159286:exon17:c.G1751T:p.R584L

IKBKB 145 CIN III Yes 8 42147718 42147718 G T nonsynonymous_SNV IKBKB:NM_001190720:exon3:c.G239T:p.G80V

KDM4B 145 CIN III Yes 19 5110752 5110752 G A synonymous_SNV KDM4B:NM_015015:exon10:c.G1038A:p.R346R

KDM5D 145 CIN III Yes Y 21878316 21878316 C T nonsynonymous_SNV KDM5D:NM_001146706:exon14:c.G1709A:p.R570Q

KDR 145 CIN III Yes 4 55979625 55979625 G T nonsynonymous_SNV KDR:NM_002253:exon7:c.C822A:p.N274K

KRAS 145 CIN III Yes 12 25398281 25398281 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G38A:p.G13D

MAP3K14 145 CIN III Yes 17 43343972 43343972 G A unknown UNKNOWN

MLL5 145 CIN III Yes 7 104730465 104730465 G T nonsynonymous_SNV MLL5:NM_018682:exon13:c.G1368T:p.K456N

NTRK1 145 CIN III Yes 1 156843514 156843514 C T nonsynonymous_SNV NTRK1:NM_001012331:exon8:c.C940T:p.R314C

PIK3CA 145 CIN III Yes 3 178936082 178936082 G A nonsynonymous_SNV p.E542K

PLCB2 145 CIN III Yes 15 40584362 40584362 G T splicing mutation PLCB2(NM_004573:exon24:c.2432-3C>A)

PRKDC 145 CIN III Yes 8 48691604 48691604 G T unknown UNKNOWN

PTPN23 145 CIN III Yes 3 47451602 47451602 C A nonsynonymous_SNV PTPN23:NM_015466:exon20:c.C2314A:p.P772T

PTPRF 145 CIN III Yes 1 44069692 44069692 G C nonsynonymous_SNV PTPRF:NM_130440:exon15:c.G2842C:p.D948H

PTPRF 145 CIN III Yes 1 44056827 44056827 C A synonymous_SNV PTPRF:NM_002840:exon9:c.C1134A:p.G378G

PTPRG 145 CIN III Yes 3 62189189 62189189 G A nonsynonymous_SNV PTPRG:NM_002841:exon12:c.G1720A:p.G574S

PTPRT 145 CIN III Yes 20 40979303 40979303 C A nonsynonymous_SNV PTPRT:NM_007050:exon11:c.G1830T:p.M610I

RASA1 145 CIN III Yes 5 86685316 86685316 C T nonsynonymous_SNV RASA1:NM_002890:exon24:c.C3032T:p.T1011M

RASA1 145 CIN III Yes 5 86670116 86670116 G T nonsynonymous_SNV RASA1:NM_002890:exon14:c.G1913T:p.W638L

RASGRP1 145 CIN III Yes 15 38805081 38805081 C A nonsynonymous_SNV RASGRP1:NM_001128602:exon7:c.G752T:p.C251F

REL 145 CIN III Yes 2 61118941 61118941 G A nonsynonymous_SNV REL:NM_002908:exon2:c.G134A:p.R45Q

RGS4 145 CIN III Yes 1 163042184 163042184 G T splicing mutation RGS4(NM_001102445:exon3:c.336-1G>T

RYR1 145 CIN III Yes 19 39008172 39008172 C T nonsynonymous_SNV RYR1:NM_000540:exon66:c.C9859T:p.R3287C

SMAD5 145 CIN III Yes 5 135513036 135513036 C T unknown UNKNOWN

SMARCA1 145 CIN III Yes X 128640151 128640151 C T nonsynonymous_SNV SMARCA1:NM_003069:exon8:c.G1004A:p.R335H

SMARCA2 145 CIN III Yes 9 2033051 2033051 C A nonsynonymous_SNV SMARCA2:NM_003070:exon3:c.C325A:p.P109T

SMARCA4 145 CIN III Yes 19 11097188 11097188 G A nonsynonymous_SNV SMARCA4:NM_001128845:exon3:c.G679A:p.A227T

SMARCA4 145 CIN III Yes 19 11144463 11144463 C A synonymous_SNV SMARCA4:NM_001128849:exon27:c.C3795A:p.G1265G

SMARCA5 145 CIN III Yes 4 144469229 144469229 G A nonsynonymous_SNV SMARCA5:NM_003601:exon22:c.G2921A:p.R974Q

SRC 145 CIN III Yes 20 36024584 36024584 G T synonymous_SNV SRC:NM_005417:exon8:c.G573T:p.V191V

STK11 145 CIN III Yes 19 1218479 1218479 C T synonymous_SNV STK11:NM_000455:exon2:c.C354T:p.Y118Y TRAF2 145 CIN III Yes 9 139794074 139794074 G T nonsynonymous_SNV TRAF2:NM_021138:exon3:c.G217T:p.V73F

ALK 147 CIN IV Yes, at diagnosis 2 29498096 29498096 G T splicing mutation ALK(NM_004304:exon12:c.1913-3C>A)

APC 147 CIN IV Yes, at diagnosis 5 112170801 112170801 G T stopgain_SNV APC:NM_001127511:exon13:c.G1843T:p.E615X

CTNNA3 147 CIN IV Yes, at diagnosis 10 67680175 67680175 C T synonymous_SNV CTNNA3:NM_001127384:exon18:c.G2601A:p.T867T

CTNNBL1 147 CIN IV Yes, at diagnosis 20 36407717 36407717 G T nonsynonymous_SNV CTNNBL1:NM_030877:exon10:c.G1011T:p.Q337H

EPHB1 147 CIN IV Yes, at diagnosis 3 134670357 134670357 C T nonsynonymous_SNV EPHB1:NM_004441:exon3:c.C268T:p.R90C

JAK1 147 CIN IV Yes, at diagnosis 1 65339154 65339154 G A nonsynonymous_SNV JAK1:NM_002227:exon5:c.C382T:p.R128C

JUN 147 CIN IV Yes, at diagnosis 1 59248117 59248117 - T frameshift_insertion JUN:NM_002228:exon1:c.626dupA:p.H209fs

KRAS 147 CIN IV Yes, at diagnosis 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

LGR6 147 CIN IV Yes, at diagnosis 1 202287454 202287454 C T nonsynonymous_SNV LGR6:NM_001017404:exon16:c.C1606T:p.R536W

PLCB4 147 CIN IV Yes, at diagnosis 20 9382163 9382163 G A nonsynonymous_SNV PLCB4:NM_000933:exon17:c.G1537A:p.E513K

SLC24A4 147 CIN IV Yes, at diagnosis 14 92920379 92920379 G A nonsynonymous_SNV SLC24A4:NM_153646:exon11:c.G1016A:p.R339Q

SMARCC1 147 CIN IV Yes, at diagnosis 3 47823276 47823276 C A synonymous_SNV SMARCC1:NM_003074:exon1:c.G12T:p.A4A

TCF7L2 147 CIN IV Yes, at diagnosis 10 114711350 114711350 C A stopgain_SNV TCF7L2:NM_001146274:exon3:c.C365A:p.S122X

AKAP13 149 CIN IV Yes, at diagnosis 15 86076993 86076993 C A nonsynonymous_SNV AKAP13:NM_006738:exon4:c.C360A:p.D120E

AKAP13 149 CIN IV Yes, at diagnosis 15 86284330 86284330 C T synonymous_SNV AKAP13:NM_001270546:exon27:c.C3525T:p.S1175S

APC 149 CIN IV Yes, at diagnosis 5 112128191 112128191 C T stopgain_SNV APC:NM_000038:exon7:c.C694T:p.R232X

APC 149 CIN IV Yes, at diagnosis 5 112175000 112175000 C T stopgain_SNV APC:NM_001127511:exon14:c.C3655T:p.Q1219X

ATM 149 CIN IV Yes, at diagnosis 11 108137925 108137925 C T nonsynonymous_SNV ATM:NM_000051:exon17:c.C2494T:p.R832C

ATP2A2 149 CIN IV Yes, at diagnosis 12 110778629 110778629 C - frameshift_deletion ATP2A2:NM_001681:exon14:c.1927delC:p.Q643fs

BRAF 149 CIN IV Yes, at diagnosis 7 140508777 140508777 C A nonsynonymous_SNV BRAF:NM_004333:exon4:c.G523T:p.V175F

CACNA1G 149 CIN IV Yes, at diagnosis 17 48680533 48680533 G T nonsynonymous_SNV CACNA1G:NM_001256332:exon20:c.G4073T:p.R1358L

CHD7 149 CIN IV Yes, at diagnosis 8 61736578 61736578 C A splicing mutation CHD7(NM_017780:exon13:c.3378+3C>A)

DNMT1 149 CIN IV Yes, at diagnosis 19 10251817 10251817 G A nonsynonymous_SNV DNMT1:NM_001379:exon30:c.C3310T:p.R1104C

DVL2 149 CIN IV Yes, at diagnosis 17 7132556 7132556 C T synonymous_SNV DVL2:NM_004422:exon8:c.G855A:p.Q285Q

EPHB2 149 CIN IV Yes, at diagnosis 1 23111221 23111221 C T nonsynonymous_SNV EPHB2:NM_004442:exon3:c.C463T:p.R155C

GNAS 149 CIN IV Yes, at diagnosis 20 57428938 57428938 G T nonsynonymous_SNV GNAS:NM_001077490:exon1:c.G431T:p.G144V

GRIN2A 149 CIN IV Yes, at diagnosis 16 9934531 9934531 C T nonsynonymous_SNV GRIN2A:NM_001134407:exon7:c.G1624A:p.G542S

HDAC7 149 CIN IV Yes, at diagnosis 12 48188683 48188683 G A nonsynonymous_SNV HDAC7:NM_001098416:exon11:c.C1207T:p.R403W

HDAC9 149 CIN IV Yes, at diagnosis 7 18767219 18767219 C T nonsynonymous_SNV HDAC9:NM_058176:exon12:c.C1739T:p.T580M

INSRR 149 CIN IV Yes, at diagnosis 1 156819053 156819053 C T nonsynonymous_SNV INSRR:NM_014215:exon6:c.G1429A:p.G477R

IRS2 149 CIN IV Yes, at diagnosis 13 110436171 110436171 G A nonsynonymous_SNV IRS2:NM_003749:exon1:c.C2230T:p.R744C

JAK2 149 CIN IV Yes, at diagnosis 9 5080247 5080247 C A nonsynonymous_SNV JAK2:NM_004972:exon17:c.C2150A:p.P717Q

KDM6A 149 CIN IV Yes, at diagnosis X 44921907 44921907 C T nonsynonymous_SNV KDM6A:NM_021140:exon15:c.C1441T:p.R481C LTK 149 CIN IV Yes, at diagnosis 15 41796716 41796716 C A nonsynonymous_SNV LTK:NM_001135685:exon16:c.G1853T:p.C618F

MAP3K10 149 CIN IV Yes, at diagnosis 19 40704369 40704369 A C nonsynonymous_SNV MAP3K10:NM_002446:exon2:c.A770C:p.K257T

MAPK10 149 CIN IV Yes, at diagnosis 4 87080573 87080573 G T nonsynonymous_SNV MAPK10:NM_002753:exon4:c.C114A:p.N38K

MTHFR 149 CIN IV Yes, at diagnosis 1 11861416 11861416 C T nonsynonymous_SNV MTHFR:NM_005957:exon3:c.G277A:p.V93M

NAV3 149 CIN IV Yes, at diagnosis 12 78401186 78401186 G C nonsynonymous_SNV NAV3:NM_014903:exon8:c.G1868C:p.S623T

NAV3 149 CIN IV Yes, at diagnosis 12 78515789 78515789 A T synonymous_SNV NAV3:NM_014903:exon16:c.A3819T:p.S1273S

NR4A1 149 CIN IV Yes, at diagnosis 12 52448860 52448860 G A nonsynonymous_SNV NR4A1:NM_173157:exon2:c.G748A:p.V250M

NTRK2 149 CIN IV Yes, at diagnosis 9 87322786 87322786 T A nonsynonymous_SNV NTRK2:NM_001007097:exon5:c.T387A:p.S129R

PLCE1 149 CIN IV Yes, at diagnosis 10 95995717 95995717 G T stopgain_SNV PLCE1:NM_001165979:exon6:c.G1336T:p.G446X

PLCG2 149 CIN IV Yes, at diagnosis 16 81965166 81965166 C T synonymous_SNV PLCG2:NM_002661:exon25:c.C2646T:p.G882G

PTPRT 149 CIN IV Yes, at diagnosis 20 41101008 41101008 G A stopgain_SNV PTPRT:NM_007050:exon8:c.C1348T:p.R450X

RASGRP3 149 CIN IV Yes, at diagnosis 2 33783941 33783941 G T nonsynonymous_SNV RASGRP3:NM_015376:exon16:c.G1905T:p.M635I

RYR1 149 CIN IV Yes, at diagnosis 19 38946182 38946182 G A synonymous_SNV RYR1:NM_000540:exon15:c.G1668A:p.S556S

RYR3 149 CIN IV Yes, at diagnosis 15 34093017 34093017 C T nonsynonymous_SNV RYR3:NM_001036:exon68:c.C9877T:p.R3293C

SLC24A1 149 CIN IV Yes, at diagnosis 15 65918061 65918061 G - frameshift_deletion SLC24A1:NM_004727:exon2:c.1643delG:p.R548fs

SMARCC1 149 CIN IV Yes, at diagnosis 3 47712212 47712212 G A splicing mutation SMARCC1(NM_003074:exon20:c.1840-5C>T)

SMG1 149 CIN IV Yes, at diagnosis 16 18839362 18839362 T C synonymous_SNV SMG1:NM_015092:exon55:c.A9732G:p.A3244A

TP53 149 CIN IV Yes, at diagnosis 17 7577120 7577120 C T nonsynonymous_SNV TP53:NM_001126115:exon4:c.G422A:p.R141H

TP53 149 CIN IV Yes, at diagnosis 17 7578274 7578274 T A nonsynonymous_SNV TP53:NM_001126115:exon2:c.A179T:p.Q60L

ULK1 149 CIN IV Yes, at diagnosis 12 132403211 132403211 G A synonymous_SNV ULK1:NM_003565:exon23:c.G2496A:p.E832E

AATK 151 CIN IV Yes, at diagnosis 17 79096358 79096358 C T nonsynonymous_SNV AATK:NM_004920:exon10:c.G1069A:p.A357T

APC 151 CIN IV Yes, at diagnosis 5 112175185 112175185 T - frameshift_deletion APC:NM_001127511:exon14:c.3840delT:p.S1280fs

ARID1A 151 CIN IV Yes, at diagnosis 1 27106134 27106134 G A synonymous_SNV ARID1A:NM_006015:exon20:c.G5745A:p.L1915L

CACNA1B 151 CIN IV Yes, at diagnosis 9 140772542 140772542 G A nonsynonymous_SNV CACNA1B:NM_000718:exon1:c.G157A:p.A53T

HSP90B1 151 CIN IV Yes, at diagnosis 12 104340418 104340418 A T nonsynonymous_SNV HSP90B1:NM_003299:exon15:c.A2050T:p.T684S

ITPR1 151 CIN IV Yes, at diagnosis 3 4730182 4730182 G A nonsynonymous_SNV ITPR1:NM_001168272:exon30:c.G3661A:p.E1221K

KRAS 151 CIN IV Yes, at diagnosis 12 25378562 25378562 C T nonsynonymous_SNV KRAS:NM_004985:exon4:c.G436A:p.A146T

MLL4 151 CIN IV Yes, at diagnosis 19 36211880 36211880 G A nonsynonymous_SNV MLL4:NM_014727:exon3:c.G1631A:p.R544Q

MUSK 151 CIN IV Yes, at diagnosis 9 113538101 113538101 C T synonymous_SNV MUSK:NM_001166281:exon8:c.C954T:p.C318C

NFKBIL1 151 CIN IV Yes, at diagnosis 6 31515976 31515976 C T nonsynonymous_SNV NFKBIL1:NM_001144961:exon2:c.C94T:p.R32C

PIK3CA 151 CIN IV Yes, at diagnosis 3 178936091 178936091 G A nonsynonymous_SNV p.E545K

SMARCA1 151 CIN IV Yes, at diagnosis X 128657298 128657298 G A nonsynonymous_SNV SMARCA1:NM_003069:exon1:c.C50T:p.A17V

TXK 151 CIN IV Yes, at diagnosis 4 48073590 48073590 G A nonsynonymous_SNV TXK:NM_003328:exon14:c.C1459T:p.R487C

AATK 153 MSI-H IV Yes, at diagnosis 17 79093833 79093833 C T synonymous_SNV AATK:NM_004920:exon11:c.G3477A:p.S1159S AATK 153 MSI-H IV Yes, at diagnosis 17 79096356 79096356 C T synonymous_SNV AATK:NM_004920:exon10:c.G1071A:p.A357A

ACTL6B 153 MSI-H IV Yes, at diagnosis 7 100253065 100253065 A G nonsynonymous_SNV ACTL6B:NM_016188:exon3:c.T247C:p.S83P

ACVR1B 153 MSI-H IV Yes, at diagnosis 12 52370268 52370268 C T synonymous_SNV ACVR1B:NM_004302:exon3:c.C489T:p.D163D

ACVR2A 153 MSI-H IV Yes, at diagnosis 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ACVR2B 153 MSI-H IV Yes, at diagnosis 3 38518906 38518906 G A nonsynonymous_SNV ACVR2B:NM_001106:exon2:c.G181A:p.A61T

AKAP12 153 MSI-H IV Yes, at diagnosis 6 151671336 151671336 A - frameshift_deletion AKAP12:NM_144497:exon2:c.1516delA:p.R506fs

AKAP12 153 MSI-H IV Yes, at diagnosis 6 151673502 151673502 G A nonsynonymous_SNV AKAP12:NM_144497:exon2:c.G3682A:p.A1228T

AKAP13 153 MSI-H IV Yes, at diagnosis 15 86284292 86284292 C T stopgain_SNV AKAP13:NM_001270546:exon27:c.C3487T:p.Q1163X

AKAP2,PALM2-AKAP2 153 MSI-H IV Yes, at diagnosis 9 112900482 112900482 G - frameshift_deletion AKAP2:NM_001004065:exon2:c.2232delG:p.G744fs

AKAP2,PALM2-AKAP2 153 MSI-H IV Yes, at diagnosis 9 112900489 112900489 C - frameshift_deletion AKAP2:NM_001004065:exon2:c.2239delC:p.Q747fs

AKAP6 153 MSI-H IV Yes, at diagnosis 14 32902739 32902739 C T stopgain_SNV AKAP6:NM_004274:exon2:c.C40T:p.Q14X

AKAP8 153 MSI-H IV Yes, at diagnosis 19 15483889 15483889 G - frameshift_deletion AKAP8:NM_005858:exon5:c.634delC:p.P212fs

AKAP9 153 MSI-H IV Yes, at diagnosis 7 91709097 91709097 A C nonsynonymous_SNV AKAP9:NM_005751:exon31:c.A7650C:p.K2550N

AKAP9 153 MSI-H IV Yes, at diagnosis 7 91690643 91690643 G A nonsynonymous_SNV AKAP9:NM_005751:exon23:c.G5671A:p.E1891K

AKT1 153 MSI-H IV Yes, at diagnosis 14 105258975 105258975 G A synonymous_SNV AKT1:NM_001014431:exon2:c.C6T:p.S2S

ALK 153 MSI-H IV Yes, at diagnosis 2 29519811 29519811 T C nonsynonymous_SNV ALK:NM_004304:exon9:c.A1760G:p.Y587C

APC2 153 MSI-H IV Yes, at diagnosis 19 1457143 1457143 G A nonsynonymous_SNV APC2:NM_005883:exon9:c.G1108A:p.V370I

ARID1A 153 MSI-H IV Yes, at diagnosis 1 27056317 27056317 C T nonsynonymous_SNV ARID1A:NM_006015:exon2:c.C1313T:p.A438V

ARID1B 153 MSI-H IV Yes, at diagnosis 6 157099426 157099426 - CAG nonframeshift_insertion ARID1B:NM_017519:exon1:c.363_364insCAG:p.Q121delinsQQ

ARID1B 153 MSI-H IV Yes, at diagnosis 6 157099426 157099426 A G synonymous_SNV ARID1B:NM_017519:exon1:c.A363G:p.Q121Q

ARID2 153 MSI-H IV Yes, at diagnosis 12 46211619 46211619 A - frameshift_deletion ARID2:NM_152641:exon5:c.585delA:p.K195fs

ATP2B2 153 MSI-H IV Yes, at diagnosis 3 10391870 10391870 C T nonsynonymous_SNV ATP2B2:NM_001683:exon13:c.G2195A:p.R732Q

ATP2B4 153 MSI-H IV Yes, at diagnosis 1 203667357 203667357 A - frameshift_deletion ATP2B4:NM_001001396:exon3:c.266delA:p.K89fs

ATR 153 MSI-H IV Yes, at diagnosis 3 142274749 142274749 T - frameshift_deletion ATR:NM_001184:exon10:c.2311delA:p.K771fs

AXIN1 153 MSI-H IV Yes, at diagnosis 16 343585 343585 G - frameshift_deletion AXIN1:NM_003502:exon8:c.2089delC:p.P697fs

AXL 153 MSI-H IV Yes, at diagnosis 19 41743939 41743939 C - frameshift_deletion AXL:NM_001699:exon7:c.874delC:p.H292fs

BMPR2 153 MSI-H IV Yes, at diagnosis 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BMPR2 153 MSI-H IV Yes, at diagnosis 2 203420514 203420514 - C frameshift_insertion BMPR2:NM_001204:exon12:c.2126dupC:p.P709fs

BRAF 153 MSI-H IV Yes, at diagnosis 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

BRD1 153 MSI-H IV Yes, at diagnosis 22 50181114 50181114 C T synonymous_SNV BRD1:NM_014577:exon7:c.G2388A:p.Q796Q

CACNA1A 153 MSI-H IV Yes, at diagnosis 19 13319692 13319692 G - frameshift_deletion CACNA1A:NM_001127221:exon46:c.6661delC:p.P2221fs

CACNA1A 153 MSI-H IV Yes, at diagnosis 19 13319694 13319694 T - frameshift_deletion CACNA1A:NM_001127221:exon46:c.6659delA:p.H2220fs

CACNA1C 153 MSI-H IV Yes, at diagnosis 12 2719725 2719725 G A nonsynonymous_SNV CACNA1C:NM_000719:exon28:c.G3577A:p.A1193T

CACNA1C 153 MSI-H IV Yes, at diagnosis 12 2602556 2602556 C T splicing mutation CACNA1C(NM_001129841:exon7:c.1113+4C>T CACNA1E 153 MSI-H IV Yes, at diagnosis 1 181764093 181764093 C T stopgain_SNV CACNA1E:NM_001205294:exon44:c.C5935T:p.R1979X

CACNA1G 153 MSI-H IV Yes, at diagnosis 17 48676809 48676809 G A synonymous_SNV CACNA1G:NM_001256332:exon16:c.G3210A:p.P1070P

CACNA1H 153 MSI-H IV Yes, at diagnosis 16 1269103 1269103 C - frameshift_deletion CACNA1H:NM_001005407:exon33:c.6003delC:p.P2001fs

CACNA1H 153 MSI-H IV Yes, at diagnosis 16 1270186 1270186 C T nonsynonymous_SNV CACNA1H:NM_001005407:exon34:c.C6236T:p.A2079V

CACNA1H 153 MSI-H IV Yes, at diagnosis 16 1259340 1259340 G A synonymous_SNV CACNA1H:NM_001005407:exon17:c.G3672A:p.L1224L

CACNA1I 153 MSI-H IV Yes, at diagnosis 22 40082268 40082268 G T nonsynonymous_SNV CACNA1I:NM_001003406:exon36:c.G6425T:p.S2142I

CACNA2D1 153 MSI-H IV Yes, at diagnosis 7 81964550 81964550 T C synonymous_SNV CACNA2D1:NM_000722:exon3:c.A195G:p.Q65Q

CACNG1 153 MSI-H IV Yes, at diagnosis 17 65040888 65040888 C - frameshift_deletion CACNG1:NM_000727:exon1:c.112delC:p.H38fs

CACNG2 153 MSI-H IV Yes, at diagnosis 22 36962472 36962472 T C nonsynonymous_SNV CACNG2:NM_006078:exon3:c.A364G:p.I122V

CACNG2 153 MSI-H IV Yes, at diagnosis 22 36962532 36962532 T C nonsynonymous_SNV CACNG2:NM_006078:exon3:c.A304G:p.R102G

CACNG4 153 MSI-H IV Yes, at diagnosis 17 64961106 64961106 G A nonsynonymous_SNV CACNG4:NM_014405:exon1:c.G79A:p.A27T

CDH1 153 MSI-H IV Yes, at diagnosis 16 68771347 68771347 - GCT nonframeshift_insertion CDH1:NM_004360:exon1:c.29_30insGCT:p.A10delinsAL

CDH1 153 MSI-H IV Yes, at diagnosis 16 68844164 68844164 C T nonsynonymous_SNV CDH1:NM_004360:exon6:c.C752T:p.T251M

CDH1 153 MSI-H IV Yes, at diagnosis 16 68835743 68835743 A G nonsynonymous_SNV CDH1:NM_004360:exon3:c.A334G:p.T112A

CDH20 153 MSI-H IV Yes, at diagnosis 18 59166446 59166446 G T stopgain_SNV CDH20:NM_031891:exon2:c.G274T:p.G92X

CDKN2A 153 MSI-H IV Yes, at diagnosis 9 21974742 21974742 G A nonsynonymous_SNV CDKN2A:NM_000077:exon1:c.C85T:p.R29W

CHD6 153 MSI-H IV Yes, at diagnosis 20 40033778 40033778 - C frameshift_insertion CHD6:NM_032221:exon37:c.7603dupG:p.G2535fs

CHD7 153 MSI-H IV Yes, at diagnosis 8 61778287 61778287 C T nonsynonymous_SNV CHD7:NM_017780:exon38:c.C8789T:p.A2930V

CHD7 153 MSI-H IV Yes, at diagnosis 8 61764730 61764730 C T nonsynonymous_SNV CHD7:NM_017780:exon29:c.C5818T:p.R1940C

CHD7 153 MSI-H IV Yes, at diagnosis 8 61735230 61735230 C T synonymous_SNV CHD7:NM_017780:exon12:c.C3126T:p.N1042N

CREBBP 153 MSI-H IV Yes, at diagnosis 16 3817727 3817727 T - frameshift_deletion CREBBP:NM_001079846:exon15:c.3130delA:p.K1044fs

CREBBP 153 MSI-H IV Yes, at diagnosis 16 3824650 3824650 G A nonsynonymous_SNV CREBBP:NM_001079846:exon11:c.C2089T:p.P697S

CTNNA2 153 MSI-H IV Yes, at diagnosis 2 80801384 80801384 C T nonsynonymous_SNV CTNNA2:NM_001164883:exon13:c.C1838T:p.S613F

CTNNBL1 153 MSI-H IV Yes, at diagnosis 20 36361422 36361422 A - frameshift_deletion CTNNBL1:NM_030877:exon2:c.172delA:p.R58fs

CYP2A6 153 MSI-H IV Yes, at diagnosis 19 41354126 41354126 G A stopgain_SNV CYP2A6:NM_000762:exon4:c.C652T:p.Q218X

DAXX 153 MSI-H IV Yes, at diagnosis 6 33287505 33287505 G A nonsynonymous_SNV DAXX:NM_001254717:exon5:c.C1367T:p.S456L

DNAH3 153 MSI-H IV Yes, at diagnosis 16 21008629 21008629 C - frameshift_deletion DNAH3:NM_017539:exon44:c.6577delG:p.G2193fs

DNMT1 153 MSI-H IV Yes, at diagnosis 19 10251488 10251488 G A synonymous_SNV DNMT1:NM_001379:exon31:c.C3444T:p.C1148C

DOCK3 153 MSI-H IV Yes, at diagnosis 3 51112828 51112828 T C nonsynonymous_SNV DOCK3:NM_004947:exon7:c.T506C:p.V169A

DPYD 153 MSI-H IV Yes, at diagnosis 1 97771797 97771797 A - frameshift_deletion DPYD:NM_000110:exon17:c.2115delT:p.P705fs

DPYS 153 MSI-H IV Yes, at diagnosis 8 105393433 105393433 T G nonsynonymous_SNV DPYS:NM_001385:exon9:c.A1553C:p.H518P

DVL3 153 MSI-H IV Yes, at diagnosis 3 183888387 183888387 C - frameshift_deletion DVL3:NM_004423:exon15:c.1995delC:p.P665fs

EP300 153 MSI-H IV Yes, at diagnosis 22 41574647 41574647 A G nonsynonymous_SNV EP300:NM_001429:exon31:c.A6932G:p.Q2311R

EP400 153 MSI-H IV Yes, at diagnosis 12 132549326 132549326 G A synonymous_SNV EP400:NM_015409:exon48:c.G8448A:p.S2816S EPHA8 153 MSI-H IV Yes, at diagnosis 1 22915487 22915487 G A nonsynonymous_SNV EPHA8:NM_001006943:exon5:c.G1103A:p.R368H

EPHA8 153 MSI-H IV Yes, at diagnosis 1 22924653 22924653 C T nonsynonymous_SNV EPHA8:NM_020526:exon12:c.C2126T:p.A709V

EPHB1 153 MSI-H IV Yes, at diagnosis 3 134968273 134968273 G T nonsynonymous_SNV EPHB1:NM_004441:exon15:c.G2786T:p.R929M

EPHB4 153 MSI-H IV Yes, at diagnosis 7 100414974 100414974 G A synonymous_SNV EPHB4:NM_004444:exon8:c.C1428T:p.A476A

EPHB6 153 MSI-H IV Yes, at diagnosis 7 142562052 142562054 CCT - nonframeshift_deletion EPHB6:NM_004445:exon7:c.494_496del:p.165_166del

ERBB4 153 MSI-H IV Yes, at diagnosis 2 212288933 212288933 C T nonsynonymous_SNV ERBB4:NM_001042599:exon23:c.G2813A:p.R938H

FES 153 MSI-H IV Yes, at diagnosis 15 91430560 91430560 C T nonsynonymous_SNV FES:NM_001143783:exon3:c.C454T:p.R152W

FGFR3 153 MSI-H IV Yes, at diagnosis 4 1808946 1808946 T C nonsynonymous_SNV FGFR3:NM_022965:exon16:c.T2042C:p.L681P

FGFR4 153 MSI-H IV Yes, at diagnosis 5 176522606 176522606 C - frameshift_deletion FGFR4:NM_022963:exon11:c.1583delC:p.P528fs

FLT4 153 MSI-H IV Yes, at diagnosis 5 180055902 180055902 G - frameshift_deletion FLT4:NM_002020:exon8:c.1083delC:p.Y361fs

FLT4 153 MSI-H IV Yes, at diagnosis 5 180048663 180048663 G A synonymous_SNV FLT4:NM_002020:exon13:c.C1899T:p.H633H

FNDC1 153 MSI-H IV Yes, at diagnosis 6 159660695 159660695 A - frameshift_deletion FNDC1:NM_032532:exon14:c.4327delA:p.T1443fs

FTCD 153 MSI-H IV Yes, at diagnosis 21 47558506 47558506 C T synonymous_SNV FTCD:NM_006657:exon12:c.G1359A:p.T453T

GRIN2C 153 MSI-H IV Yes, at diagnosis 17 72842921 72842921 C T nonsynonymous_SNV GRIN2C:NM_000835:exon10:c.G2140A:p.A714T

GRIN2D 153 MSI-H IV Yes, at diagnosis 19 48946522 48946522 G A synonymous_SNV GRIN2D:NM_000836:exon13:c.G3339A:p.S1113S

GSK3B 153 MSI-H IV Yes, at diagnosis 3 119812235 119812235 G A nonsynonymous_SNV GSK3B:NM_001146156:exon1:c.C47T:p.P16L

HCFC1 153 MSI-H IV Yes, at diagnosis X 153215870 153215870 G A nonsynonymous_SNV HCFC1:NM_005334:exon24:c.C5828T:p.P1943L

HCFC2 153 MSI-H IV Yes, at diagnosis 12 104480687 104480687 A G nonsynonymous_SNV HCFC2:NM_013320:exon8:c.A1126G:p.K376E

HDAC2 153 MSI-H IV Yes, at diagnosis 6 114292048 114292048 T - frameshift_deletion HDAC2:NM_001527:exon1:c.25delA:p.K9fs

HDAC4 153 MSI-H IV Yes, at diagnosis 2 240078379 240078379 G A synonymous_SNV HDAC4:NM_006037:exon7:c.C702T:p.D234D

HDAC5 153 MSI-H IV Yes, at diagnosis 17 42170126 42170126 G - frameshift_deletion HDAC5:NM_001015053:exon7:c.693delC:p.G231fs

HOXA3 153 MSI-H IV Yes, at diagnosis 7 27148289 27148289 G A nonsynonymous_SNV HOXA3:NM_030661:exon3:c.C577T:p.R193C

IKBKAP 153 MSI-H IV Yes, at diagnosis 9 111681594 111681594 T C synonymous_SNV IKBKAP:NM_003640:exon7:c.A588G:p.P196P

INSRR 153 MSI-H IV Yes, at diagnosis 1 156821555 156821555 G A synonymous_SNV INSRR:NM_014215:exon4:c.C967T:p.L323L

INSRR 153 MSI-H IV Yes, at diagnosis 1 156815575 156815575 C T synonymous_SNV INSRR:NM_014215:exon10:c.G2010A:p.P670P

ITPR1 153 MSI-H IV Yes, at diagnosis 3 4714954 4714954 C T nonsynonymous_SNV ITPR1:NM_001168272:exon20:c.C2294T:p.A765V

ITPR1 153 MSI-H IV Yes, at diagnosis 3 4714886 4714886 A G synonymous_SNV ITPR1:NM_001168272:exon20:c.A2226G:p.S742S

ITPR3 153 MSI-H IV Yes, at diagnosis 6 33652233 33652233 C - stopgain_SNV ITPR3:NM_002224:exon37:c.5037delC:p.Y1679X

JAK1 153 MSI-H IV Yes, at diagnosis 1 65303627 65303627 C T nonsynonymous_SNV JAK1:NM_002227:exon22:c.G3128A:p.S1043N

JMJD1C 153 MSI-H IV Yes, at diagnosis 10 64960294 64960294 - T frameshift_insertion JMJD1C:NM_004241:exon8:c.4561dupA:p.K1521fs

KAT2A 153 MSI-H IV Yes, at diagnosis 17 40273262 40273262 A G nonsynonymous_SNV KAT2A:NM_021078:exon1:c.T61C:p.S21P

KAT6A 153 MSI-H IV Yes, at diagnosis 8 41790354 41790354 G C nonsynonymous_SNV KAT6A:NM_006766:exon17:c.C5384G:p.A1795G

KDM4D 153 MSI-H IV Yes, at diagnosis 11 94730814 94730814 A - frameshift_deletion KDM4D:NM_018039:exon3:c.278delA:p.K93fs

KDM4D 153 MSI-H IV Yes, at diagnosis 11 94731059 94731059 G A nonsynonymous_SNV KDM4D:NM_018039:exon3:c.G523A:p.V175I KDM5A 153 MSI-H IV Yes, at diagnosis 12 459908 459908 C T nonsynonymous_SNV KDM5A:NM_001042603:exon10:c.G1187A:p.R396Q

KDM6A 153 MSI-H IV Yes, at diagnosis X 44938498 44938498 G A nonsynonymous_SNV KDM6A:NM_021140:exon20:c.G3046A:p.G1016R

KDM6B 153 MSI-H IV Yes, at diagnosis 17 7756404 7756404 G A nonsynonymous_SNV KDM6B:NM_001080424:exon21:c.G4697A:p.R1566H

KDM6B 153 MSI-H IV Yes, at diagnosis 17 7753247 7753247 C A synonymous_SNV KDM6B:NM_001080424:exon12:c.C3549A:p.P1183P

KDM8 153 MSI-H IV Yes, at diagnosis 16 27231782 27231782 G A synonymous_SNV KDM8:NM_001145348:exon7:c.G1176A:p.T392T

LYN 153 MSI-H IV Yes, at diagnosis 8 56863060 56863060 A - frameshift_deletion LYN:NM_001111097:exon5:c.264delA:p.K88fs

MAP2K5 153 MSI-H IV Yes, at diagnosis 15 67835732 67835732 G A nonsynonymous_SNV MAP2K5:NM_002757:exon1:c.G59A:p.R20H

MAP2K7 153 MSI-H IV Yes, at diagnosis 19 7974718 7974718 C A nonsynonymous_SNV MAP2K7:NM_145185:exon2:c.C203A:p.P68H

MAP2K7 153 MSI-H IV Yes, at diagnosis 19 7974713 7974713 G A synonymous_SNV MAP2K7:NM_145185:exon2:c.G198A:p.T66T

MAP3K10 153 MSI-H IV Yes, at diagnosis 19 40711987 40711987 G A nonsynonymous_SNV MAP3K10:NM_002446:exon5:c.G1358A:p.R453H

MAPK15 153 MSI-H IV Yes, at diagnosis 8 144804324 144804324 G - frameshift_deletion MAPK15:NM_139021:exon14:c.1538delG:p.G513fs

MAPK15 153 MSI-H IV Yes, at diagnosis 8 144800446 144800446 A G nonsynonymous_SNV MAPK15:NM_139021:exon4:c.A260G:p.D87G

MAPK4 153 MSI-H IV Yes, at diagnosis 18 48190376 48190376 C T synonymous_SNV MAPK4:NM_002747:exon2:c.C48T:p.L16L

MEN1 153 MSI-H IV Yes, at diagnosis 11 64574661 64574661 G A nonsynonymous_SNV MEN1:NM_000244:exon5:c.C829T:p.H277Y

MERTK 153 MSI-H IV Yes, at diagnosis 2 112705095 112705095 C T synonymous_SNV MERTK:NM_006343:exon4:c.C708T:p.S236S

MLH3 153 MSI-H IV Yes, at diagnosis 14 75516071 75516071 G T synonymous_SNV MLH3:NM_001040108:exon2:c.C288A:p.A96A

MLL 153 MSI-H IV Yes, at diagnosis 11 118391570 118391570 A - frameshift_deletion MLL:NM_001197104:exon34:c.11483delA:p.K3828fs

MLL 153 MSI-H IV Yes, at diagnosis 11 118343107 118343107 G A nonsynonymous_SNV MLL:NM_001197104:exon3:c.G1233A:p.M411I

MLL 153 MSI-H IV Yes, at diagnosis 11 118376683 118376683 C T nonsynonymous_SNV MLL:NM_001197104:exon27:c.C10076T:p.A3359V

MLL3 153 MSI-H IV Yes, at diagnosis 7 151879372 151879372 G A nonsynonymous_SNV MLL3:NM_170606:exon36:c.C5573T:p.A1858V

MLLT1 153 MSI-H IV Yes, at diagnosis 19 6222150 6222150 C A nonsynonymous_SNV MLLT1:NM_005934:exon6:c.G1092T:p.E364D

MRE11A 153 MSI-H IV Yes, at diagnosis 11 94219206 94219206 C A nonsynonymous_SNV MRE11A:NM_005590:exon4:c.G198T:p.K66N

MSH6 153 MSI-H IV Yes, at diagnosis 2 48030646 48030647 CC - frameshift_deletion MSH6:NM_000179:exon5:c.3260_3261del:p.1087_1087del

MTR 153 MSI-H IV Yes, at diagnosis 1 236979779 236979779 C A synonymous_SNV MTR:NM_000254:exon8:c.C700A:p.R234R

MTRR 153 MSI-H IV Yes, at diagnosis 5 7885930 7885930 C T synonymous_SNV MTRR:NM_002454:exon7:c.C1020T:p.C340C

MUSK 153 MSI-H IV Yes, at diagnosis 9 113550037 113550037 T C nonsynonymous_SNV MUSK:NM_001166281:exon11:c.T1558C:p.S520P

MYC 153 MSI-H IV Yes, at diagnosis 8 128750699 128750699 G A nonsynonymous_SNV MYC:NM_002467:exon2:c.G236A:p.S79N

NAV3 153 MSI-H IV Yes, at diagnosis 12 78513365 78513365 - A frameshift_insertion NAV3:NM_014903:exon15:c.3389dupA:p.K1130fs

NAV3 153 MSI-H IV Yes, at diagnosis 12 78571055 78571055 T G nonsynonymous_SNV NAV3:NM_014903:exon27:c.T5259G:p.C1753W

NAV3 153 MSI-H IV Yes, at diagnosis 12 78591131 78591131 C T synonymous_SNV NAV3:NM_014903:exon34:c.C6330T:p.G2110G

NFKB2 153 MSI-H IV Yes, at diagnosis 10 104159135 104159135 G - frameshift_deletion NFKB2:NM_001261403:exon12:c.1208delG:p.G403fs

P2RX5 153 MSI-H IV Yes, at diagnosis 17 3593817 3593817 C A nonsynonymous_SNV P2RX5:NM_001204520:exon4:c.G365T:p.G122V

P2RX7 153 MSI-H IV Yes, at diagnosis 12 121622121 121622121 A G nonsynonymous_SNV P2RX7:NM_002562:exon13:c.A1304G:p.D435G

PAK3 153 MSI-H IV Yes, at diagnosis X 110395675 110395675 G A synonymous_SNV PAK3:NM_001128167:exon5:c.G468A:p.S156S PAK4 153 MSI-H IV Yes, at diagnosis 19 39663791 39663791 C T synonymous_SNV PAK4:NM_001014832:exon3:c.C438T:p.G146G

PAK6 153 MSI-H IV Yes, at diagnosis 15 40566361 40566361 G T nonsynonymous_SNV PAK6:NM_001276717:exon8:c.G1762T:p.G588C

PER1 153 MSI-H IV Yes, at diagnosis 17 8049283 8049283 C T synonymous_SNV PER1:NM_002616:exon17:c.G2211A:p.P737P

PIAS2 153 MSI-H IV Yes, at diagnosis 18 44426786 44426786 T - frameshift_deletion PIAS2:NM_004671:exon6:c.745delA:p.K249fs

PIK3C2A 153 MSI-H IV Yes, at diagnosis 11 17143812 17143812 C T synonymous_SNV PIK3C2A:NM_002645:exon14:c.G2580A:p.Q860Q

PIK3C2G 153 MSI-H IV Yes, at diagnosis 12 18576964 18576964 G A nonsynonymous_SNV PIK3C2G:NM_004570:exon17:c.G2372A:p.R791H

PIK3CA 153 MSI-H IV Yes, at diagnosis 3 178936091 178936091 G A nonsynonymous_SNV p.E545K

PIK3R1 153 MSI-H IV Yes, at diagnosis 5 67522747 67522747 A - frameshift_deletion PIK3R1:NM_181523:exon2:c.244delA:p.I82fs

PLCB2 153 MSI-H IV Yes, at diagnosis 15 40599846 40599846 G - frameshift_deletion PLCB2:NM_004573:exon1:c.28delC:p.P10fs

PLCD1 153 MSI-H IV Yes, at diagnosis 3 38051460 38051460 T C nonsynonymous_SNV PLCD1:NM_001130964:exon8:c.A1285G:p.I429V

PLCE1 153 MSI-H IV Yes, at diagnosis 10 96058279 96058279 A C synonymous_SNV PLCE1:NM_001165979:exon23:c.A4387C:p.R1463R

PLCG2 153 MSI-H IV Yes, at diagnosis 16 81979861 81979861 C T nonsynonymous_SNV PLCG2:NM_002661:exon31:c.C3563T:p.P1188L

PLCG2 153 MSI-H IV Yes, at diagnosis 16 81934352 81934352 G A synonymous_SNV PLCG2:NM_002661:exon14:c.G1329A:p.S443S

PRKDC 153 MSI-H IV Yes, at diagnosis 8 48803033 48803033 C T unknown UNKNOWN

PRKDC 153 MSI-H IV Yes, at diagnosis 8 48866919 48866919 T - unknown UNKNOWN

PTPRD 153 MSI-H IV Yes, at diagnosis 9 8524967 8524967 C T nonsynonymous_SNV PTPRD:NM_001040712:exon6:c.G628A:p.A210T

PTPRF 153 MSI-H IV Yes, at diagnosis 1 44086820 44086820 C T nonsynonymous_SNV PTPRF:NM_130440:exon32:c.C5545T:p.R1849C

PTPRJ 153 MSI-H IV Yes, at diagnosis 11 48149596 48149596 G A splicing mutation PTPRJ(NM_002843:exon7:c.1357+1G>A

PTPRK 153 MSI-H IV Yes, at diagnosis 6 128505782 128505782 G A synonymous_SNV PTPRK:NM_001135648:exon7:c.C957T:p.G319G

PTPRM 153 MSI-H IV Yes, at diagnosis 18 8244188 8244188 G A synonymous_SNV PTPRM:NM_001105244:exon15:c.G2433A:p.T811T

PTPRM 153 MSI-H IV Yes, at diagnosis 18 8069928 8069928 G A synonymous_SNV PTPRM:NM_001105244:exon8:c.G1377A:p.L459L

PTPRN 153 MSI-H IV Yes, at diagnosis 2 220172549 220172549 C T nonsynonymous_SNV PTPRN:NM_001199763:exon2:c.G131A:p.R44H

PTPRQ 153 MSI-H IV Yes, at diagnosis 12 81067035 81067035 A T synonymous_SNV PTPRQ:NM_001145026:exon40:c.A6174T:p.G2058G

PTPRT 153 MSI-H IV Yes, at diagnosis 20 40748583 40748583 G A nonsynonymous_SNV PTPRT:NM_007050:exon20:c.C2876T:p.A959V

PTPRT 153 MSI-H IV Yes, at diagnosis 20 40713420 40713420 C T synonymous_SNV PTPRT:NM_007050:exon29:c.G4038A:p.T1346T

RASA1 153 MSI-H IV Yes, at diagnosis 5 86645099 86645099 C T nonsynonymous_SNV RASA1:NM_002890:exon8:c.C1171T:p.R391W

RASGRP2 153 MSI-H IV Yes, at diagnosis 11 64497606 64497606 - C frameshift_insertion RASGRP2:NM_001098670:exon13:c.1473dupG:p.L491fs

RASGRP4 153 MSI-H IV Yes, at diagnosis 19 38910889 38910889 G A stopgain_SNV RASGRP4:NM_001146202:exon5:c.C391T:p.R131X

RNF111 153 MSI-H IV Yes, at diagnosis 15 59376348 59376348 C - frameshift_deletion RNF111:NM_001270528:exon9:c.2345delC:p.P782fs

ROS1 153 MSI-H IV Yes, at diagnosis 6 117639347 117639347 C T splicing mutation ROS1(NM_002944:exon38:c.6005+4G>A)

RPTOR 153 MSI-H IV Yes, at diagnosis 17 78681776 78681776 G A nonsynonymous_SNV RPTOR:NM_001163034:exon4:c.G484A:p.G162R

RYR1 153 MSI-H IV Yes, at diagnosis 19 38997486 38997486 C - frameshift_deletion RYR1:NM_000540:exon57:c.8710delC:p.L2904fs

RYR1 153 MSI-H IV Yes, at diagnosis 19 38951060 38951060 G C synonymous_SNV RYR1:NM_000540:exon20:c.G2406C:p.L802L

RYR2 153 MSI-H IV Yes, at diagnosis 1 237947838 237947838 G A nonsynonymous_SNV RYR2:NM_001035:exon90:c.G12826A:p.V4276M RYR3 153 MSI-H IV Yes, at diagnosis 15 34129916 34129916 T C nonsynonymous_SNV RYR3:NM_001243996:exon88:c.T11720C:p.F3907S

SETD1B 153 MSI-H IV Yes, at diagnosis 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SETD1B 153 MSI-H IV Yes, at diagnosis 12 122248553 122248553 G T nonsynonymous_SNV SETD1B:NM_015048:exon5:c.G1702T:p.G568C

SETD1B 153 MSI-H IV Yes, at diagnosis 12 122247890 122247890 C T nonsynonymous_SNV SETD1B:NM_015048:exon5:c.C1039T:p.R347W

SHC2 153 MSI-H IV Yes, at diagnosis 19 460970 460970 C G synonymous_SNV SHC2:NM_012435:exon1:c.G27C:p.A9A

SHC2 153 MSI-H IV Yes, at diagnosis 19 422218 422218 G A synonymous_SNV SHC2:NM_012435:exon11:c.C1548T:p.P516P

SKIL 153 MSI-H IV Yes, at diagnosis 3 170109019 170109019 A G nonsynonymous_SNV SKIL:NM_001145097:exon5:c.A1729G:p.K577E

SLC24A1 153 MSI-H IV Yes, at diagnosis 15 65943269 65943269 G A nonsynonymous_SNV SLC24A1:NM_001254740:exon4:c.G763A:p.V255I

SLC24A2 153 MSI-H IV Yes, at diagnosis 9 19785940 19785940 C T nonsynonymous_SNV SLC24A2:NM_001193288:exon1:c.G925A:p.A309T

SLC24A3 153 MSI-H IV Yes, at diagnosis 20 19654289 19654291 TCA - nonframeshift_deletion SLC24A3:NM_020689:exon9:c.758_760del:p.253_254del

SLC24A3 153 MSI-H IV Yes, at diagnosis 20 19560663 19560663 C T nonsynonymous_SNV SLC24A3:NM_020689:exon4:c.C368T:p.A123V

SLC8A1 153 MSI-H IV Yes, at diagnosis 2 40402422 40402422 C A splicing mutation SLC8A1(NM_001112800:exon4:c.1916-1G>T

SMARCA2 153 MSI-H IV Yes, at diagnosis 9 2039776 2039776 - CAG nonframeshift_insertion SMARCA2:NM_003070:exon4:c.666_667insCAG:p.Q222delinsQQ

SMARCA4 153 MSI-H IV Yes, at diagnosis 19 11152148 11152148 C G nonsynonymous_SNV SMARCA4:NM_001128845:exon28:c.C4246G:p.P1416A

SMARCA4 153 MSI-H IV Yes, at diagnosis 19 11101829 11101829 C T nonsynonymous_SNV SMARCA4:NM_001128845:exon7:c.C1249T:p.R417C

SMARCC1 153 MSI-H IV Yes, at diagnosis 3 47677565 47677565 - T frameshift_insertion SMARCC1:NM_003074:exon23:c.2438dupA:p.E813fs

SMARCD3 153 MSI-H IV Yes, at diagnosis 7 150936546 150936546 C T nonsynonymous_SNV SMARCD3:NM_001003801:exon12:c.G1334A:p.R445H

SMARCE1 153 MSI-H IV Yes, at diagnosis 17 38792651 38792651 T - frameshift_deletion SMARCE1:NM_003079:exon6:c.365delA:p.E122fs

SMARCE1 153 MSI-H IV Yes, at diagnosis 17 38793779 38793779 T C nonsynonymous_SNV SMARCE1:NM_003079:exon5:c.A202G:p.K68E

SMURF1 153 MSI-H IV Yes, at diagnosis 7 98649880 98649880 C T synonymous_SNV SMURF1:NM_001199847:exon7:c.G669A:p.T223T

SOS2 153 MSI-H IV Yes, at diagnosis 14 50626269 50626269 T C nonsynonymous_SNV SOS2:NM_006939:exon10:c.A1732G:p.K578E

SOS2 153 MSI-H IV Yes, at diagnosis 14 50626706 50626706 C T nonsynonymous_SNV SOS2:NM_006939:exon10:c.G1295A:p.G432D

STAT3 153 MSI-H IV Yes, at diagnosis 17 40475309 40475309 T - frameshift_deletion STAT3:NM_003150:exon19:c.1717delA:p.K573fs

STAT3 153 MSI-H IV Yes, at diagnosis 17 40475061 40475063 CTT - nonframeshift_deletion STAT3:NM_003150:exon20:c.1847_1849del:p.616_617del

STAT5B 153 MSI-H IV Yes, at diagnosis 17 40375464 40375464 T - frameshift_deletion STAT5B:NM_012448:exon5:c.486delA:p.L162fs

STAT6 153 MSI-H IV Yes, at diagnosis 12 57498351 57498351 G A nonsynonymous_SNV STAT6:NM_001178081:exon9:c.C778T:p.R260W

SYNGAP1 153 MSI-H IV Yes, at diagnosis 6 33411566 33411566 C T synonymous_SNV SYNGAP1:NM_006772:exon15:c.C3237T:p.S1079S

TCF7L1 153 MSI-H IV Yes, at diagnosis 2 85360979 85360979 G A nonsynonymous_SNV TCF7L1:NM_031283:exon1:c.G172A:p.A58T

TDG 153 MSI-H IV Yes, at diagnosis 12 104378523 104378523 C G splicing mutation TDG(NM_003211:exon8:c.793-4C>G)

TGFBR2 153 MSI-H IV Yes, at diagnosis 3 30691880 30691881 AA - frameshift_deletion TGFBR2:NM_003242:exon3:c.382_383del:p.128_128del

TIE1 153 MSI-H IV Yes, at diagnosis 1 43774758 43774758 C T nonsynonymous_SNV TIE1:NM_001253357:exon8:c.C1009T:p.R337W

TIE1 153 MSI-H IV Yes, at diagnosis 1 43782937 43782937 C A nonsynonymous_SNV TIE1:NM_001253357:exon15:c.C2342A:p.P781H

TIE1 153 MSI-H IV Yes, at diagnosis 1 43777338 43777338 G A splicing mutation TIE1(NM_005424:exon10:c.1334-4G>A

TNK2 153 MSI-H IV Yes, at diagnosis 3 195595236 195595236 - G frameshift_insertion TNK2:NM_005781:exon12:c.1888dupC:p.P630fs TONSL 153 MSI-H IV Yes, at diagnosis 8 145659102 145659102 T C nonsynonymous_SNV TONSL:NM_013432:exon22:c.A3428G:p.D1143G

TONSL 153 MSI-H IV Yes, at diagnosis 8 145667678 145667678 C T synonymous_SNV TONSL:NM_013432:exon6:c.G696A:p.A232A

TRAF3 153 MSI-H IV Yes, at diagnosis 14 103371682 103371682 G A nonsynonymous_SNV TRAF3:NM_001199427:exon8:c.G1019A:p.R340H

TRDN 153 MSI-H IV Yes, at diagnosis 6 123673681 123673681 T - frameshift_deletion TRDN:NM_001251987:exon21:c.1375delA:p.K459fs

TRDN 153 MSI-H IV Yes, at diagnosis 6 123592292 123592292 - T frameshift_insertion TRDN:NM_006073:exon30:c.1712dupA:p.E571fs

TRRAP 153 MSI-H IV Yes, at diagnosis 7 98519386 98519386 G A nonsynonymous_SNV TRRAP:NM_001244580:exon21:c.G2633A:p.R878H

TSC2 153 MSI-H IV Yes, at diagnosis 16 2103441 2103441 C T synonymous_SNV TSC2:NM_000548:exon4:c.C324T:p.I108I

TSC2 153 MSI-H IV Yes, at diagnosis 16 2126590 2126590 C T splicing mutation TSC2(NM_001114382:exon25:c.2837+4C>T

TYK2 153 MSI-H IV Yes, at diagnosis 19 10475522 10475522 C A splicing mutation TYK2(NM_003331:exon9:c.1209+5G>T)

UPB1 153 MSI-H IV Yes, at diagnosis 22 24919647 24919647 G A nonsynonymous_SNV UPB1:NM_016327:exon9:c.G977A:p.R326Q

WDR5 153 MSI-H IV Yes, at diagnosis 9 137023044 137023044 - A frameshift_insertion WDR5:NM_052821:exon13:c.934dupA:p.T312fs

ZAP70 153 MSI-H IV Yes, at diagnosis 2 98340775 98340775 C T synonymous_SNV ZAP70:NM_001079:exon3:c.C276T:p.D92D

ZFYVE16 153 MSI-H IV Yes, at diagnosis 5 79739079 79739079 G T nonsynonymous_SNV ZFYVE16:NM_014733:exon5:c.G2557T:p.A853S

ZNF521 153 MSI-H IV Yes, at diagnosis 18 22805035 22805035 C T nonsynonymous_SNV ZNF521:NM_015461:exon4:c.G2847A:p.M949I

ALK 155 CIN IV Yes, at diagnosis 2 29917797 29917797 G A nonsynonymous_SNV ALK:NM_004304:exon3:c.C871T:p.R291C

APC 155 CIN IV Yes, at diagnosis 5 112175532 112175532 T - frameshift_deletion APC:NM_001127511:exon14:c.4187delT:p.V1396fs

CACNA1C 155 CIN IV Yes, at diagnosis 12 2622039 2622039 A C nonsynonymous_SNV CACNA1C:NM_000719:exon9:c.A1279C:p.K427Q

CACNA1C 155 CIN IV Yes, at diagnosis 12 2622038 2622038 G T nonsynonymous_SNV CACNA1C:NM_000719:exon9:c.G1278T:p.E426D

HCFC2 155 CIN IV Yes, at diagnosis 12 104487281 104487281 T G nonsynonymous_SNV HCFC2:NM_013320:exon10:c.T1402G:p.L468V

HOXA3 155 CIN IV Yes, at diagnosis 7 27149773 27149774 GA - frameshift_deletion HOXA3:NM_030661:exon2:c.486_487del:p.162_163del

KRAS 155 CIN IV Yes, at diagnosis 12 25398282 25398282 C G nonsynonymous_SNV KRAS:NM_004985:exon2:c.G37C:p.G13R

MAPK13 155 CIN IV Yes, at diagnosis 6 36098410 36098410 A C synonymous_SNV MAPK13:NM_002754:exon1:c.A51C:p.T17T

PIAS4 155 CIN IV Yes, at diagnosis 19 4013164 4013164 G A nonsynonymous_SNV PIAS4:NM_015897:exon2:c.G271A:p.D91N

PTPRF 155 CIN IV Yes, at diagnosis 1 44044484 44044484 C T nonsynonymous_SNV PTPRF:NM_002840:exon7:c.C572T:p.A191V

SMAD4 155 CIN IV Yes, at diagnosis 18 48604707 48604707 G - frameshift_deletion SMAD4:NM_005359:exon12:c.1529delG:p.G510fs

ACVR2A 157 CIN IV Yes, at diagnosis 2 148674864 148674864 T C nonsynonymous_SNV ACVR2A:NM_001616:exon6:c.T685C:p.W229R

APC 157 CIN IV Yes, at diagnosis 5 112175586 112175586 C - frameshift_deletion APC:NM_001127511:exon14:c.4241delC:p.P1414fs

ATP2B2 157 CIN IV Yes, at diagnosis 3 10491069 10491069 G A synonymous_SNV ATP2B2:NM_001001331:exon2:c.C159T:p.T53T

FTCD 157 CIN IV Yes, at diagnosis 21 47570081 47570081 G A synonymous_SNV FTCD:NM_006657:exon7:c.C858T:p.C286C

KRAS 157 CIN IV Yes, at diagnosis 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

PTK2B 157 CIN IV Yes, at diagnosis 8 27288964 27288964 G A nonsynonymous_SNV PTK2B:NM_173175:exon9:c.G860A:p.R287H

PTPRN 157 CIN IV Yes, at diagnosis 2 220173972 220173972 C T nonsynonymous_SNV PTPRN:NM_001199763:exon1:c.G83A:p.R28H

RYR3 157 CIN IV Yes, at diagnosis 15 33916037 33916037 G C nonsynonymous_SNV RYR3:NM_001036:exon20:c.G2387C:p.G796A

SMAD3 157 CIN IV Yes, at diagnosis 15 67479780 67479780 - TC frameshift_insertion SMAD3:NM_001145104:exon6:c.502_503insTC:p.V168fs APC 159 CIN IV Yes, at diagnosis 5 112154723 112154723 C T stopgain_SNV APC:NM_001127511:exon8:c.C940T:p.R314X

APC 159 CIN IV Yes, at diagnosis 5 112175639 112175639 C T stopgain_SNV APC:NM_001127511:exon14:c.C4294T:p.R1432X

APC 159 CIN IV Yes, at diagnosis 5 112174253 112174253 G T stopgain_SNV APC:NM_001127511:exon14:c.G2908T:p.E970X

CACNB1 159 CIN IV Yes, at diagnosis 17 37340307 37340307 C T nonsynonymous_SNV CACNB1:NM_000723:exon10:c.G875A:p.R292H

ERBB4 159 CIN IV Yes, at diagnosis 2 212587212 212587212 G T synonymous_SNV ERBB4:NM_001042599:exon7:c.C789A:p.P263P

KRAS 159 CIN IV Yes, at diagnosis 12 25380185 25380185 T G nonsynonymous_SNV KRAS:NM_004985:exon3:c.A273C:p.E91D

KRAS 159 CIN IV Yes, at diagnosis 12 25380275 25380275 T A nonsynonymous_SNV KRAS:NM_004985:exon3:c.A183T:p.Q61H

PTPRS 159 CIN IV Yes, at diagnosis 19 5231460 5231460 G A synonymous_SNV PTPRS:NM_130854:exon11:c.C1977T:p.N659N

ROR2 159 CIN IV Yes, at diagnosis 9 94487020 94487020 C T nonsynonymous_SNV ROR2:NM_004560:exon9:c.G1756A:p.A586T

BRAF 163 CIN IV Yes, at diagnosis 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

KDM8 163 CIN IV Yes, at diagnosis 16 27221460 27221460 C T nonsynonymous_SNV KDM8:NM_001145348:exon2:c.C130T:p.H44Y

LEPREL1 163 CIN IV Yes, at diagnosis 3 189702340 189702340 G A nonsynonymous_SNV LEPREL1:NM_001134418:exon7:c.C685T:p.R229W

MTOR 163 CIN IV Yes, at diagnosis 1 11217330 11217330 A C nonsynonymous_SNV MTOR:NM_004958:exon30:c.T4348G:p.Y1450D

PIK3CA 163 CIN IV Yes, at diagnosis 3 178936091 178936091 G A nonsynonymous_SNV p.E545K

PIK3CA 163 CIN IV Yes, at diagnosis 3 178917478 178917478 G A nonsynonymous_SNV PIK3CA:NM_006218:exon3:c.G353A:p.G118D

TP53 163 CIN IV Yes, at diagnosis 17 7577538 7577538 C T nonsynonymous_SNV TP53:NM_001126115:exon3:c.G347A:p.R116Q

ACVR2A 165 MSI-H IV Yes, at diagnosis 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

AKAP1 165 MSI-H IV Yes, at diagnosis 17 55193503 55193503 C T synonymous_SNV AKAP1:NM_003488:exon7:c.C2313T:p.D771D

AKAP12 165 MSI-H IV Yes, at diagnosis 6 151672373 151672373 G A synonymous_SNV AKAP12:NM_144497:exon2:c.G2553A:p.T851T

AKAP2,PALM2-AKAP2 165 MSI-H IV Yes, at diagnosis 9 112900197 112900197 G A synonymous_SNV AKAP2:NM_001004065:exon2:c.G1947A:p.P649P

AKAP9 165 MSI-H IV Yes, at diagnosis 7 91732069 91732069 G T nonsynonymous_SNV AKAP9:NM_005751:exon46:c.G11259T:p.E3753D

AKT1 165 MSI-H IV Yes, at diagnosis 14 105242008 105242008 G A nonsynonymous_SNV AKT1:NM_001014431:exon5:c.C416T:p.A139V

ALK 165 MSI-H IV Yes, at diagnosis 2 29443675 29443675 C T nonsynonymous_SNV ALK:NM_004304:exon23:c.G3542A:p.R1181H

APC 165 MSI-H IV Yes, at diagnosis 5 112175655 112175655 A - frameshift_deletion APC:NM_001127511:exon14:c.4310delA:p.N1437fs

ARID1A 165 MSI-H IV Yes, at diagnosis 1 27057682 27057682 C T stopgain_SNV ARID1A:NM_006015:exon3:c.C1390T:p.Q464X

ARID1B 165 MSI-H IV Yes, at diagnosis 6 157510901 157510901 A G nonsynonymous_SNV ARID1B:NM_017519:exon13:c.A3637G:p.M1213V

ARID2 165 MSI-H IV Yes, at diagnosis 12 46246298 46246298 C T synonymous_SNV ARID2:NM_152641:exon15:c.C4392T:p.R1464R

ATM 165 MSI-H IV Yes, at diagnosis 11 108172515 108172515 A - frameshift_deletion ATM:NM_000051:exon35:c.5318delA:p.K1773fs

ATR 165 MSI-H IV Yes, at diagnosis 3 142269072 142269072 G A stopgain_SNV ATR:NM_001184:exon14:c.C2878T:p.R960X

BAZ2B 165 MSI-H IV Yes, at diagnosis 2 160242861 160242861 - T splicing mutation BAZ2B(NM_013450:exon23:c.3471+3->A)

BAZ2B 165 MSI-H IV Yes, at diagnosis 2 160289434 160289434 C T synonymous_SNV BAZ2B:NM_013450:exon9:c.G1734A:p.Q578Q

BMPR2 165 MSI-H IV Yes, at diagnosis 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

CACNA1C 165 MSI-H IV Yes, at diagnosis 12 2719790 2719790 C T synonymous_SNV CACNA1C:NM_000719:exon28:c.C3642T:p.Y1214Y

CACNB2 165 MSI-H IV Yes, at diagnosis 10 18828565 18828565 A C nonsynonymous_SNV CACNB2:NM_000724:exon13:c.A1730C:p.D577A CALM3 165 MSI-H IV Yes, at diagnosis 19 47111743 47111743 C T synonymous_SNV CALM3:NM_005184:exon4:c.C183T:p.N61N

CCNE1 165 MSI-H IV Yes, at diagnosis 19 30314639 30314639 G A synonymous_SNV CCNE1:NM_001238:exon12:c.G1188A:p.P396P

CHD3 165 MSI-H IV Yes, at diagnosis 17 7798771 7798771 - C frameshift_insertion CHD3:NM_001005271:exon10:c.1795dupC:p.R599fs

CHD5 165 MSI-H IV Yes, at diagnosis 1 6166475 6166475 G A nonsynonymous_SNV CHD5:NM_015557:exon40:c.C5837T:p.P1946L

CHD5 165 MSI-H IV Yes, at diagnosis 1 6202617 6202617 C T nonsynonymous_SNV CHD5:NM_015557:exon14:c.G2092A:p.G698S

CHD9 165 MSI-H IV Yes, at diagnosis 16 53256578 53256578 A G nonsynonymous_SNV CHD9:NM_025134:exon4:c.A1807G:p.K603E

CSF1R 165 MSI-H IV Yes, at diagnosis 5 149457737 149457737 C T nonsynonymous_SNV CSF1R:NM_005211:exon5:c.G667A:p.V223M

CTNNA2 165 MSI-H IV Yes, at diagnosis 2 80136866 80136866 G A synonymous_SNV CTNNA2:NM_001164883:exon7:c.G999A:p.A333A

CTNNA2 165 MSI-H IV Yes, at diagnosis 2 79878740 79878740 C A synonymous_SNV CTNNA2:NM_001164883:exon2:c.C58A:p.R20R

CTNNA3 165 MSI-H IV Yes, at diagnosis 10 67680260 67680260 G A nonsynonymous_SNV CTNNA3:NM_001127384:exon18:c.C2516T:p.A839V

CUL1 165 MSI-H IV Yes, at diagnosis 7 148457587 148457587 A - frameshift_deletion CUL1:NM_003592:exon7:c.788delA:p.K263fs

DDR1 165 MSI-H IV Yes, at diagnosis 6 30862399 30862399 G A nonsynonymous_SNV DDR1:NM_001202522:exon10:c.G1382A:p.G461D

DDR1 165 MSI-H IV Yes, at diagnosis 6 30861113 30861113 C T synonymous_SNV DDR1:NM_001202521:exon9:c.C1260T:p.I420I

DNAH3 165 MSI-H IV Yes, at diagnosis 16 20996946 20996946 T - frameshift_deletion DNAH3:NM_017539:exon48:c.7118delA:p.Q2373fs

DNAH3 165 MSI-H IV Yes, at diagnosis 16 20976517 20976517 C T nonsynonymous_SNV DNAH3:NM_017539:exon53:c.G8689A:p.V2897M

DNMT1 165 MSI-H IV Yes, at diagnosis 19 10262088 10262088 C T nonsynonymous_SNV DNMT1:NM_001379:exon23:c.G2203A:p.G735R

DOCK3 165 MSI-H IV Yes, at diagnosis 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

DVL1 165 MSI-H IV Yes, at diagnosis 1 1275141 1275141 G A synonymous_SNV DVL1:NM_004421:exon9:c.C961T:p.L321L

EP300 165 MSI-H IV Yes, at diagnosis 22 41568502 41568502 G T splicing mutation EP300(NM_001429:exon28:c.4453-1G>T)

EP400 165 MSI-H IV Yes, at diagnosis 12 132547094 132547096 CAG - nonframeshift_deletion EP400:NM_015409:exon47:c.8182_8184del:p.2728_2728del

EPHA10 165 MSI-H IV Yes, at diagnosis 1 38227576 38227576 G A synonymous_SNV EPHA10:NM_001099439:exon3:c.C351T:p.G117G

FBXW7 165 MSI-H IV Yes, at diagnosis 4 153249366 153249366 T - frameshift_deletion FBXW7:NM_001013415:exon8:c.1058delA:p.E353fs

FNDC1 165 MSI-H IV Yes, at diagnosis 6 159655397 159655397 G A nonsynonymous_SNV FNDC1:NM_032532:exon11:c.G3853A:p.A1285T

FNDC1 165 MSI-H IV Yes, at diagnosis 6 159636059 159636059 C A synonymous_SNV FNDC1:NM_032532:exon5:c.C543A:p.R181R

GRIN2A 165 MSI-H IV Yes, at diagnosis 16 9862749 9862749 C T nonsynonymous_SNV GRIN2A:NM_001134407:exon12:c.G2554A:p.V852M

GRIN2A 165 MSI-H IV Yes, at diagnosis 16 9857854 9857854 G A stopgain_SNV GRIN2A:NM_001134407:exon13:c.C3547T:p.Q1183X

HDAC2 165 MSI-H IV Yes, at diagnosis 6 114292048 114292048 T - frameshift_deletion HDAC2:NM_001527:exon1:c.25delA:p.K9fs

IRS1 165 MSI-H IV Yes, at diagnosis 2 227662682 227662682 C T nonsynonymous_SNV IRS1:NM_005544:exon1:c.G773A:p.R258Q

ITPR1 165 MSI-H IV Yes, at diagnosis 3 4699832 4699832 C T stopgain_SNV ITPR1:NM_001168272:exon12:c.C976T:p.R326X

ITPR2 165 MSI-H IV Yes, at diagnosis 12 26640052 26640052 T - frameshift_deletion ITPR2:NM_002223:exon40:c.5503delA:p.K1835fs

ITPR3 165 MSI-H IV Yes, at diagnosis 6 33663508 33663508 G A nonsynonymous_SNV ITPR3:NM_002224:exon58:c.G7967A:p.R2656H

ITPR3 165 MSI-H IV Yes, at diagnosis 6 33662757 33662757 G C nonsynonymous_SNV ITPR3:NM_002224:exon57:c.G7842C:p.E2614D

JARID2 165 MSI-H IV Yes, at diagnosis 6 15497247 15497247 C T synonymous_SNV JARID2:NM_001267040:exon7:c.C1275T:p.P425P

KDM5C 165 MSI-H IV Yes, at diagnosis X 53247522 53247522 T C nonsynonymous_SNV KDM5C:NM_004187:exon3:c.A287G:p.Q96R KDM6B 165 MSI-H IV Yes, at diagnosis 17 7751566 7751566 C - frameshift_deletion KDM6B:NM_001080424:exon11:c.1960delC:p.Q654fs

KDM6B 165 MSI-H IV Yes, at diagnosis 17 7751887 7751887 A G nonsynonymous_SNV KDM6B:NM_001080424:exon11:c.A2281G:p.T761A

KDM6B 165 MSI-H IV Yes, at diagnosis 17 7751886 7751886 C G synonymous_SNV KDM6B:NM_001080424:exon11:c.C2280G:p.T760T

KDR 165 MSI-H IV Yes, at diagnosis 4 55946228 55946228 G A synonymous_SNV KDR:NM_002253:exon30:c.C3951T:p.T1317T

KIT 165 MSI-H IV Yes, at diagnosis 4 55594094 55594094 G A splicing mutation KIT(NM_000222:exon12:c.1879+1G>A

KRAS 165 MSI-H IV Yes, at diagnosis 12 25398284 25398284 C A nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35T:p.G12V

LCK 165 MSI-H IV Yes, at diagnosis 1 32751169 32751169 G A nonsynonymous_SNV LCK:NM_001042771:exon13:c.G1382A:p.R461H

MAP3K8 165 MSI-H IV Yes, at diagnosis 10 30747135 30747135 T C synonymous_SNV MAP3K8:NM_001244134:exon6:c.T996C:p.P332P

MAPK7 165 MSI-H IV Yes, at diagnosis 17 19282217 19282217 G A nonsynonymous_SNV MAPK7:NM_002749:exon2:c.G4A:p.A2T

MAPK8IP1 165 MSI-H IV Yes, at diagnosis 11 45923976 45923976 - C frameshift_insertion MAPK8IP1:NM_005456:exon5:c.658dupC:p.Q220fs

MAPK8IP3 165 MSI-H IV Yes, at diagnosis 16 1812884 1812884 G A nonsynonymous_SNV MAPK8IP3:NM_001040439:exon15:c.G1754A:p.R585H

MERTK 165 MSI-H IV Yes, at diagnosis 2 112786058 112786058 G A nonsynonymous_SNV MERTK:NM_006343:exon19:c.G2617A:p.V873I

MLL3 165 MSI-H IV Yes, at diagnosis 7 151845529 151845529 A - frameshift_deletion MLL3:NM_170606:exon52:c.13483delT:p.F4495fs

MLL3 165 MSI-H IV Yes, at diagnosis 7 151874156 151874156 T - frameshift_deletion MLL3:NM_170606:exon38:c.8382delA:p.P2794fs

MLL4 165 MSI-H IV Yes, at diagnosis 19 36224223 36224223 C - frameshift_deletion MLL4:NM_014727:exon28:c.6773delC:p.P2258fs

MSH2 165 MSI-H IV Yes, at diagnosis 2 47639594 47639594 A - frameshift_deletion MSH2:NM_000251:exon4:c.687delA:p.K229fs

MSH2 165 MSI-H IV Yes, at diagnosis 2 47635615 47635615 G A nonsynonymous_SNV MSH2:NM_000251:exon2:c.G287A:p.R96H

MSH6 165 MSI-H IV Yes, at diagnosis 2 48026525 48026525 G A nonsynonymous_SNV MSH6:NM_000179:exon4:c.G1403A:p.R468H

P2RX4 165 MSI-H IV Yes, at diagnosis 12 121671344 121671344 G A nonsynonymous_SNV P2RX4:NM_001261397:exon12:c.G1078A:p.D360N

P2RX6 165 MSI-H IV Yes, at diagnosis 22 21369573 21369573 G A nonsynonymous_SNV P2RX6:NM_005446:exon1:c.G110A:p.R37Q

PAK3 165 MSI-H IV Yes, at diagnosis X 110437543 110437543 A G nonsynonymous_SNV PAK3:NM_001128167:exon11:c.A1007G:p.D336G

PAK7 165 MSI-H IV Yes, at diagnosis 20 9523317 9523317 C A nonsynonymous_SNV PAK7:NM_177990:exon9:c.G1920T:p.E640D

PDGFRB 165 MSI-H IV Yes, at diagnosis 5 149512471 149512471 G A synonymous_SNV PDGFRB:NM_002609:exon7:c.C969T:p.G323G

PDK2 165 MSI-H IV Yes, at diagnosis 17 48183476 48183476 G - frameshift_deletion PDK2:NM_001199900:exon4:c.560delG:p.G187fs

PIK3CA 165 MSI-H IV Yes, at diagnosis 3 178952072 178952072 A C nonsynonymous_SNV PIK3CA:NM_006218:exon21:c.A3127C:p.M1043L

PLCB3 165 MSI-H IV Yes, at diagnosis 11 64031588 64031588 A G splicing mutation PLCB3(NM_000932:exon22:c.2652+4A>G

PTK2B 165 MSI-H IV Yes, at diagnosis 8 27297939 27297939 G A nonsynonymous_SNV PTK2B:NM_173175:exon21:c.G2020A:p.E674K

PTPN13 165 MSI-H IV Yes, at diagnosis 4 87683996 87683996 A G nonsynonymous_SNV PTPN13:NM_080684:exon21:c.A3097G:p.T1033A

PTPN22 165 MSI-H IV Yes, at diagnosis 1 114402081 114402081 T G nonsynonymous_SNV PTPN22:NM_001193431:exon2:c.A89C:p.K30T

PTPN23 165 MSI-H IV Yes, at diagnosis 3 47450450 47450450 T C synonymous_SNV PTPN23:NM_015466:exon16:c.T1515C:p.H505H

PTPRD 165 MSI-H IV Yes, at diagnosis 9 8499682 8499682 G A nonsynonymous_SNV PTPRD:NM_002839:exon25:c.C2287T:p.P763S

PTPRN2 165 MSI-H IV Yes, at diagnosis 7 157369389 157369389 G A nonsynonymous_SNV PTPRN2:NM_130842:exon18:c.C2648T:p.T883M

PTPRN2 165 MSI-H IV Yes, at diagnosis 7 157449184 157449184 C T synonymous_SNV PTPRN2:NM_130842:exon13:c.G2010A:p.T670T

ROR2 165 MSI-H IV Yes, at diagnosis 9 94488906 94488906 A C nonsynonymous_SNV ROR2:NM_004560:exon8:c.T1303G:p.S435A ROS1 165 MSI-H IV Yes, at diagnosis 6 117650535 117650535 C T nonsynonymous_SNV ROS1:NM_002944:exon32:c.G5323A:p.E1775K

RYR1 165 MSI-H IV Yes, at diagnosis 19 38931418 38931418 G A nonsynonymous_SNV RYR1:NM_000540:exon2:c.G79A:p.V27M

RYR2 165 MSI-H IV Yes, at diagnosis 1 237969502 237969502 T - frameshift_deletion RYR2:NM_001035:exon99:c.14217delT:p.F4739fs

RYR2 165 MSI-H IV Yes, at diagnosis 1 237494265 237494265 G A nonsynonymous_SNV RYR2:NM_001035:exon3:c.G256A:p.V86M

RYR2 165 MSI-H IV Yes, at diagnosis 1 237659992 237659992 G T stopgain_SNV RYR2:NM_001035:exon20:c.G2143T:p.G715X

RYR3 165 MSI-H IV Yes, at diagnosis 15 33952493 33952493 C T synonymous_SNV RYR3:NM_001036:exon34:c.C4491T:p.P1497P

SETD1B 165 MSI-H IV Yes, at diagnosis 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SLC24A1 165 MSI-H IV Yes, at diagnosis 15 65916578 65916578 G T nonsynonymous_SNV SLC24A1:NM_004727:exon2:c.G160T:p.V54F

SLC24A1 165 MSI-H IV Yes, at diagnosis 15 65946318 65946318 C T synonymous_SNV SLC24A1:NM_001254740:exon7:c.C1182T:p.N394N

SLC8A2 165 MSI-H IV Yes, at diagnosis 19 47969008 47969008 A - frameshift_deletion SLC8A2:NM_015063:exon2:c.653delT:p.V218fs

SLC8A2 165 MSI-H IV Yes, at diagnosis 19 47944678 47944678 T C nonsynonymous_SNV SLC8A2:NM_015063:exon5:c.A1783G:p.I595V

SMAD9 165 MSI-H IV Yes, at diagnosis 13 37446984 37446984 G A nonsynonymous_SNV SMAD9:NM_001127217:exon3:c.C481T:p.R161C

SMARCA5 165 MSI-H IV Yes, at diagnosis 4 144442716 144442716 A - frameshift_deletion SMARCA5:NM_003601:exon3:c.387delA:p.K129fs

SMARCC2 165 MSI-H IV Yes, at diagnosis 12 56575357 56575357 G A nonsynonymous_SNV SMARCC2:NM_001130420:exon10:c.C865T:p.R289W

STAT4 165 MSI-H IV Yes, at diagnosis 2 191926472 191926472 C T synonymous_SNV STAT4:NM_001243835:exon10:c.G1017A:p.Q339Q

TCF7L2 165 MSI-H IV Yes, at diagnosis 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TGFBR2 165 MSI-H IV Yes, at diagnosis 3 30691880 30691881 AA - frameshift_deletion TGFBR2:NM_003242:exon3:c.382_383del:p.128_128del

TGFBR2 165 MSI-H IV Yes, at diagnosis 3 30713757 30713757 T C nonsynonymous_SNV TGFBR2:NM_003242:exon4:c.T1082C:p.L361P

TNK2 165 MSI-H IV Yes, at diagnosis 3 195595229 195595229 G A nonsynonymous_SNV TNK2:NM_005781:exon12:c.C1895T:p.P632L

TP53 165 MSI-H IV Yes, at diagnosis 17 7579476 7579476 G - frameshift_deletion TP53:NM_001126118:exon3:c.94delC:p.P32fs

TP53 165 MSI-H IV Yes, at diagnosis 17 7579329 7579329 T C nonsynonymous_SNV TP53:NM_001126118:exon3:c.A241G:p.K81E

TRDN 165 MSI-H IV Yes, at diagnosis 6 123673681 123673681 T - frameshift_deletion TRDN:NM_001251987:exon21:c.1375delA:p.K459fs

TSC1 165 MSI-H IV Yes, at diagnosis 9 135772901 135772901 G A nonsynonymous_SNV TSC1:NM_001162427:exon20:c.C2569T:p.R857W

TYRO3 165 MSI-H IV Yes, at diagnosis 15 41864743 41864743 G A nonsynonymous_SNV TYRO3:NM_006293:exon15:c.G1856A:p.R619Q

ZFYVE16 165 MSI-H IV Yes, at diagnosis 5 79752759 79752759 - T splicing mutation ZFYVE16(NM_001105251:exon14:c.3796-5->T

ATR 167 CIN IV Yes, at diagnosis 3 142272500 142272500 G T nonsynonymous_SNV ATR:NM_001184:exon12:c.C2615A:p.T872K

CACNA1A 167 CIN IV Yes, at diagnosis 19 13411386 13411386 C T nonsynonymous_SNV CACNA1A:NM_001127221:exon18:c.G2260A:p.A754T

GRIN2A 167 CIN IV Yes, at diagnosis 16 10274114 10274114 C T nonsynonymous_SNV GRIN2A:NM_001134407:exon2:c.G155A:p.R52Q

IKBKB 167 CIN IV Yes, at diagnosis 8 42171892 42171892 T G nonsynonymous_SNV IKBKB:NM_001190720:exon8:c.T739G:p.L247V

KDM3A 167 CIN IV Yes, at diagnosis 2 86683561 86683561 - T splicing mutation KDM3A(NM_018433:exon6:c.557-4->T

KDM6A 167 CIN IV Yes, at diagnosis X 44969323 44969323 G C splicing mutation KDM6A(NM_021140:exon28:c.4006-1G>C)

NR4A1 167 CIN IV Yes, at diagnosis 12 52448439 52448439 C T synonymous_SNV NR4A1:NM_173157:exon2:c.C327T:p.Y109Y

PAK2 167 CIN IV Yes, at diagnosis 3 196529926 196529926 C A synonymous_SNV PAK2:NM_002577:exon4:c.C327A:p.S109S

RYR3 167 CIN IV Yes, at diagnosis 15 34064344 34064344 G A nonsynonymous_SNV RYR3:NM_001036:exon63:c.G9040A:p.G3014R RYR3 167 CIN IV Yes, at diagnosis 15 34140527 34140527 C T synonymous_SNV RYR3:NM_001243996:exon93:c.C13518T:p.I4506I

TP53 167 CIN IV Yes, at diagnosis 17 7577121 7577121 G A nonsynonymous_SNV TP53:NM_001126115:exon4:c.C421T:p.R141C

TRDN 167 CIN IV Yes, at diagnosis 6 123786039 123786039 - G frameshift_insertion TRDN:NM_001256020:exon9:c.882_883insC:p.F295fs

APC 169 CIN IV Yes, at diagnosis 5 112175758 112175758 A - frameshift_deletion APC:NM_001127511:exon14:c.4413delA:p.L1471fs

APC 169 CIN IV Yes, at diagnosis 5 112175756 112175756 T A nonsynonymous_SNV APC:NM_001127511:exon14:c.T4411A:p.L1471I

ARID1A 169 CIN IV Yes, at diagnosis 1 27088709 27088709 C T nonsynonymous_SNV ARID1A:NM_006015:exon7:c.C2318T:p.P773L

CACNA1G 169 CIN IV Yes, at diagnosis 17 48687286 48687286 C T synonymous_SNV CACNA1G:NM_001256332:exon25:c.C4578T:p.S1526S

CTNNA2 169 CIN IV Yes, at diagnosis 2 80835383 80835383 T C synonymous_SNV CTNNA2:NM_004389:exon17:c.T2370C:p.N790N

EPHB1 169 CIN IV Yes, at diagnosis 3 134670789 134670789 G A nonsynonymous_SNV EPHB1:NM_004441:exon3:c.G700A:p.V234M

GNAS 169 CIN IV Yes, at diagnosis 20 57415597 57415597 G A nonsynonymous_SNV GNAS:NM_016592:exon1:c.G436A:p.G146S

ITPR3 169 CIN IV Yes, at diagnosis 6 33647834 33647834 C A nonsynonymous_SNV ITPR3:NM_002224:exon31:c.C4148A:p.T1383N

PAK3 169 CIN IV Yes, at diagnosis X 110439716 110439716 C T stopgain_SNV PAK3:NM_001128167:exon13:c.C1255T:p.R419X

RYR2 169 CIN IV Yes, at diagnosis 1 237802485 237802485 G A nonsynonymous_SNV RYR2:NM_001035:exon46:c.G7099A:p.G2367R

RYR3 169 CIN IV Yes, at diagnosis 15 34032054 34032054 C T stopgain_SNV RYR3:NM_001036:exon51:c.C7678T:p.R2560X

TK2 169 CIN IV Yes, at diagnosis 16 66570883 66570883 C A nonsynonymous_SNV TK2:NM_001172644:exon3:c.G194T:p.R65L

TP53 169 CIN IV Yes, at diagnosis 17 7577547 7577547 C A nonsynonymous_SNV TP53:NM_001126115:exon3:c.G338T:p.G113V

APC 171 CIN IV Yes, at diagnosis 5 112175879 112175879 G - frameshift_deletion APC:NM_001127511:exon14:c.4534delG:p.E1512fs

ATP2B4 171 CIN IV Yes, at diagnosis 1 203668636 203668636 C G nonsynonymous_SNV ATP2B4:NM_001001396:exon4:c.C440G:p.A147G

CACNG3 171 CIN IV Yes, at diagnosis 16 24366182 24366182 C A synonymous_SNV CACNG3:NM_006539:exon3:c.C324A:p.P108P

KRAS 171 CIN IV Yes, at diagnosis 12 25398284 25398284 C A nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35T:p.G12V

PIK3CA 171 CIN IV Yes, at diagnosis 3 178952084 178952084 C T nonsynonymous_SNV p.H1047Y

RYR2 171 CIN IV Yes, at diagnosis 1 237774082 237774082 G A synonymous_SNV RYR2:NM_001035:exon36:c.G4704A:p.A1568A

TP53 171 CIN IV Yes, at diagnosis 17 7574003 7574003 G A stopgain_SNV TP53:NM_001126115:exon6:c.C628T:p.R210X

APC 173 CIN III Yes 5 112162945 112162945 G T splicing mutation APC(NM_001127511:exon10:c.1494+1G>T

ASPH 173 CIN III Yes 8 62479865 62479865 A C nonsynonymous_SNV ASPH:NM_001164750:exon17:c.T1075G:p.L359V

ATM 173 CIN III Yes 11 108121568 108121568 T G nonsynonymous_SNV ATM:NM_000051:exon10:c.T1376G:p.L459R

ERBB3 173 CIN III Yes 12 56491645 56491645 G T nonsynonymous_SNV ERBB3:NM_001982:exon21:c.G2537T:p.S846I

ERBB4 173 CIN III Yes 2 212576816 212576816 C T synonymous_SNV ERBB4:NM_001042599:exon9:c.G1083A:p.K361K

GRIN2C 173 CIN III Yes 17 72850959 72850959 G A synonymous_SNV GRIN2C:NM_000835:exon2:c.C273T:p.H91H

PLCE1 173 CIN III Yes 10 95995743 95995743 G - frameshift_deletion PLCE1:NM_001165979:exon6:c.1362delG:p.E454fs

PLCE1 173 CIN III Yes 10 95995745 95995745 A - frameshift_deletion PLCE1:NM_001165979:exon6:c.1364delA:p.K455fs

TEK 173 CIN III Yes 9 27203033 27203033 C T stopgain_SNV TEK:NM_000459:exon13:c.C2125T:p.Q709X

ASH2L 175 CIN III Yes 8 37978590 37978590 G T nonsynonymous_SNV ASH2L:NM_001105214:exon10:c.G806T:p.W269L

KRAS 175 CIN III Yes 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D MUTYH 175 CIN III Yes 1 45799217 45799217 C T synonymous_SNV MUTYH:NM_001048171:exon3:c.G174A:p.P58P

PTPRT 175 CIN III Yes 20 41076870 41076870 G A nonsynonymous_SNV PTPRT:NM_007050:exon9:c.C1550T:p.T517M

RYR1 175 CIN III Yes 19 38976748 38976748 C T nonsynonymous_SNV RYR1:NM_000540:exon34:c.C5453T:p.A1818V

SETD1A 175 CIN III Yes 16 30991838 30991838 C T nonsynonymous_SNV SETD1A:NM_014712:exon15:c.C4441T:p.R1481W

TP53 175 CIN III Yes 17 7578203 7578203 C T nonsynonymous_SNV TP53:NM_001126115:exon2:c.G250A:p.V84M

APC 177 CIN II No 5 112173917 112173917 C T stopgain_SNV APC:NM_001127511:exon14:c.C2572T:p.R858X

CACNA2D3 177 CIN II No 3 54913379 54913379 A C nonsynonymous_SNV CACNA2D3:NM_018398:exon20:c.A1785C:p.K595N

MLL2 177 CIN II No 12 49437155 49437155 C A nonsynonymous_SNV MLL2:NM_003482:exon24:c.G5524T:p.D1842Y

PLCG2 177 CIN II No 16 81888077 81888077 C T synonymous_SNV PLCG2:NM_002661:exon3:c.C222T:p.R74R

TGFBR1 177 CIN II No 9 101867491 101867491 G - frameshift_deletion TGFBR1:NM_001130916:exon1:c.4delG:p.E2fs

TP53 177 CIN II No 17 7577550 7577550 C T nonsynonymous_SNV TP53:NM_001126115:exon3:c.G335A:p.G112D

BIRC2 179 MSI-L III No 11 102221118 102221118 G T nonsynonymous_SNV BIRC2:NM_001166:exon2:c.G533T:p.S178I

BIRC2 179 MSI-L III No 11 102248615 102248615 C A nonsynonymous_SNV BIRC2:NM_001166:exon8:c.C1649A:p.T550K

CAB39 179 MSI-L III No 2 231658008 231658008 C A synonymous_SNV CAB39:NM_001130849:exon4:c.C360A:p.I120I

CACNA1G 179 MSI-L III No 17 48704091 48704091 C A nonsynonymous_SNV CACNA1G:NM_198387:exon34:c.C6732A:p.D2244E

CCNE1 179 MSI-L III No 19 30311652 30311652 C A nonsynonymous_SNV CCNE1:NM_001238:exon7:c.C506A:p.A169E

CHD4 179 MSI-L III No 12 6696581 6696581 G T nonsynonymous_SNV CHD4:NM_001273:exon25:c.C3848A:p.A1283D

DPYS 179 MSI-L III No 8 105478886 105478886 T C nonsynonymous_SNV DPYS:NM_001385:exon1:c.A263G:p.K88R

DVL3 179 MSI-L III No 3 183888465 183888465 C T synonymous_SNV DVL3:NM_004423:exon15:c.C2073T:p.P691P

EP300 179 MSI-L III No 22 41513627 41513627 G T nonsynonymous_SNV EP300:NM_001429:exon2:c.G531T:p.M177I

EP300 179 MSI-L III No 22 41545117 41545117 C A nonsynonymous_SNV EP300:NM_001429:exon13:c.C2317A:p.Q773K

EPHA2 179 MSI-L III No 1 16451785 16451785 G A synonymous_SNV EPHA2:NM_004431:exon17:c.C2856T:p.P952P

EPHA4 179 MSI-L III No 2 222310899 222310899 C A nonsynonymous_SNV EPHA4:NM_004438:exon9:c.G1718T:p.R573L

EPHB3 179 MSI-L III No 3 184290318 184290318 G T nonsynonymous_SNV EPHB3:NM_004443:exon3:c.G210T:p.E70D

FHOD3 179 MSI-L III No 18 34335252 34335252 C A nonsynonymous_SNV FHOD3:NM_025135:exon22:c.C3878A:p.T1293N

GNAL 179 MSI-L III No 18 11753864 11753864 C A nonsynonymous_SNV GNAL:NM_182978:exon4:c.C544A:p.P182T

GRIN2D 179 MSI-L III No 19 48946404 48946404 C A nonsynonymous_SNV GRIN2D:NM_000836:exon13:c.C3221A:p.P1074Q

HCFC2 179 MSI-L III No 12 104492219 104492219 G T nonsynonymous_SNV HCFC2:NM_013320:exon13:c.G1839T:p.Q613H

IDH1 179 MSI-L III No 2 209104629 209104629 G A nonsynonymous_SNV IDH1:NM_005896:exon8:c.C949T:p.R317C

IGF1R 179 MSI-L III No 15 99465425 99465425 G T nonsynonymous_SNV IGF1R:NM_000875:exon11:c.G2250T:p.M750I

KAT6A 179 MSI-L III No 8 41845012 41845012 G T nonsynonymous_SNV KAT6A:NM_006766:exon3:c.C670A:p.P224T

KDM4B 179 MSI-L III No 19 5144124 5144124 C A synonymous_SNV KDM4B:NM_015015:exon19:c.C2697A:p.V899V

MLH3 179 MSI-L III No 14 75514989 75514989 G T nonsynonymous_SNV MLH3:NM_001040108:exon2:c.C1370A:p.S457Y

MLL 179 MSI-L III No 11 118374285 118374285 G T stopgain_SNV MLL:NM_001197104:exon27:c.G7678T:p.E2560X MLL3 179 MSI-L III No 7 151842295 151842295 G T nonsynonymous_SNV MLL3:NM_170606:exon54:c.C14117A:p.T4706K

MLL3 179 MSI-L III No 7 151860545 151860545 C A nonsynonymous_SNV MLL3:NM_170606:exon43:c.G10117T:p.A3373S

MLL4 179 MSI-L III No 19 36218616 36218616 G T nonsynonymous_SNV MLL4:NM_014727:exon17:c.G4320T:p.K1440N

NAV3 179 MSI-L III No 12 78515971 78515971 C A nonsynonymous_SNV NAV3:NM_014903:exon16:c.C4001A:p.A1334E

NTRK3 179 MSI-L III No 15 88679722 88679722 C A synonymous_SNV NTRK3:NM_001007156:exon8:c.G741T:p.G247G

PER1 179 MSI-L III No 17 8049375 8049375 C A nonsynonymous_SNV PER1:NM_002616:exon17:c.G2119T:p.A707S

PIAS1 179 MSI-L III No 15 68479952 68479952 C T nonsynonymous_SNV PIAS1:NM_016166:exon14:c.C1735T:p.R579W

PLCB4 179 MSI-L III No 20 9388650 9388650 C A synonymous_SNV PLCB4:NM_000933:exon18:c.C1698A:p.S566S

PRKD1 179 MSI-L III No 14 30102071 30102071 T G splicing mutation PRKD1(NM_002742:exon10:c.1392+4A>C)

PTPN2 179 MSI-L III No 18 12817196 12817196 G A nonsynonymous_SNV PTPN2:NM_002828:exon6:c.C664T:p.R222C

PTPN21 179 MSI-L III No 14 88945339 88945339 G T nonsynonymous_SNV PTPN21:NM_007039:exon13:c.C2436A:p.D812E

PTPN23 179 MSI-L III No 3 47452786 47452786 G A synonymous_SNV PTPN23:NM_015466:exon20:c.G3498A:p.E1166E

PTPRH 179 MSI-L III No 19 55703042 55703042 G T nonsynonymous_SNV PTPRH:NM_001161440:exon9:c.C1791A:p.F597L

PTPRO 179 MSI-L III No 12 15654735 15654735 C T synonymous_SNV PTPRO:NM_002848:exon5:c.C843T:p.S281S

RICTOR 179 MSI-L III No 5 38991068 38991068 G T nonsynonymous_SNV RICTOR:NM_152756:exon7:c.C566A:p.A189D

RYR1 179 MSI-L III No 19 38968466 38968466 C T synonymous_SNV RYR1:NM_000540:exon30:c.C4410T:p.V1470V

RYR2 179 MSI-L III No 1 237829850 237829850 C A synonymous_SNV RYR2:NM_001035:exon57:c.C8475A:p.A2825A

SLC24A2 179 MSI-L III No 9 19573386 19573386 C A nonsynonymous_SNV SLC24A2:NM_001193288:exon5:c.G1259T:p.G420V

SMG1 179 MSI-L III No 16 18861449 18861449 C A splicing mutation SMG1(NM_015092:exon36:c.5284-1G>T)

SMURF1 179 MSI-L III No 7 98633339 98633339 G T nonsynonymous_SNV SMURF1:NM_001199847:exon16:c.C1810A:p.L604M

SOCS6 179 MSI-L III No 18 67992775 67992775 G T nonsynonymous_SNV SOCS6:NM_004232:exon2:c.G871T:p.G291C

TNK2 179 MSI-L III No 3 195605123 195605123 C A splicing mutation TNK2(NM_001010938:exon10:c.1445+1G>T

TP53 179 MSI-L III No 17 7572991 7572991 T C nonsynonymous_SNV TP53:NM_001126115:exon7:c.A722G:p.K241R

TP53 179 MSI-L III No 17 7577548 7577548 C T nonsynonymous_SNV TP53:NM_001126115:exon3:c.G337A:p.G113S

TSC2 179 MSI-L III No 16 2136807 2136807 G A nonsynonymous_SNV TSC2:NM_001077183:exon36:c.G4723A:p.G1575S

ZFYVE16 179 MSI-L III No 5 79732691 79732691 G A nonsynonymous_SNV ZFYVE16:NM_014733:exon3:c.G187A:p.V63I

APC 181 CIN III No 5 112175551 112175552 CA - frameshift_deletion APC:NM_001127511:exon14:c.4206_4207del:p.1402_1403del

CACNA1E 181 CIN III No 1 181706685 181706685 C T synonymous_SNV CACNA1E:NM_001205294:exon22:c.C3390T:p.I1130I

CHD7 181 CIN III No 8 61761106 61761106 T C nonsynonymous_SNV CHD7:NM_017780:exon24:c.T5243C:p.L1748P

KRAS 181 CIN III No 12 25398281 25398281 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G38A:p.G13D

MAPK4 181 CIN III No 18 48255940 48255940 G A nonsynonymous_SNV MAPK4:NM_002747:exon6:c.G1480A:p.A494T

MTR 181 CIN III No 1 237060941 237060941 C G nonsynonymous_SNV MTR:NM_000254:exon33:c.C3795G:p.D1265E

NTRK2 181 CIN III No 9 87359949 87359949 C T synonymous_SNV NTRK2:NM_001007097:exon11:c.C1257T:p.S419S

PTPRT 181 CIN III No 20 40747063 40747063 T G nonsynonymous_SNV PTPRT:NM_007050:exon21:c.A2962C:p.N988H TP53 181 CIN III No 17 7574003 7574003 G A stopgain_SNV TP53:NM_001126115:exon6:c.C628T:p.R210X

ZFYVE9 181 CIN III No 1 52703746 52703746 G A synonymous_SNV ZFYVE9:NM_004799:exon4:c.G657A:p.P219P

APC 183 CIN III No 5 112151204 112151204 C T stopgain_SNV APC:NM_001127511:exon7:c.C793T:p.R265X

CACNA1H 183 CIN III No 16 1268216 1268216 C T synonymous_SNV CACNA1H:NM_001005407:exon32:c.C5434T:p.L1812L

CHD5 183 CIN III No 1 6212526 6212526 G A synonymous_SNV CHD5:NM_015557:exon6:c.C816T:p.A272A

DRD2 183 CIN III No 11 113286326 113286326 G A synonymous_SNV DRD2:NM_000795:exon5:c.C540T:p.N180N

EPHA6 183 CIN III No 3 97311535 97311535 G A synonymous_SNV EPHA6:NM_173655:exon10:c.G642A:p.P214P

HDAC11 183 CIN III No 3 13543384 13543384 G A nonsynonymous_SNV HDAC11:NM_001136041:exon7:c.G350A:p.R117H

HDAC7 183 CIN III No 12 48185773 48185773 A T nonsynonymous_SNV HDAC7:NM_001098416:exon13:c.T1582A:p.S528T

HDAC7 183 CIN III No 12 48185772 48185772 G T stopgain_SNV HDAC7:NM_001098416:exon13:c.C1583A:p.S528X

MATK 183 CIN III No 19 3783903 3783903 C T nonsynonymous_SNV MATK:NM_139354:exon5:c.G368A:p.R123H

RET 183 CIN III No 10 43596110 43596110 G A nonsynonymous_SNV RET:NM_020630:exon2:c.G277A:p.G93S

TP53 183 CIN III No 17 7577121 7577121 G A nonsynonymous_SNV TP53:NM_001126115:exon4:c.C421T:p.R141C

ADAMTSL3 185 CIN III No 15 84582093 84582093 C T synonymous_SNV ADAMTSL3:NM_207517:exon16:c.C1950T:p.Y650Y

ATP2B2 185 CIN III No 3 10382025 10382025 G T synonymous_SNV ATP2B2:NM_001683:exon18:c.C3003A:p.I1001I

BRAF 185 CIN III No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CD38 185 CIN III No 4 15826560 15826560 G A synonymous_SNV CD38:NM_001775:exon3:c.G420A:p.R140R

CTNND2 185 CIN III No 5 11159699 11159699 G A synonymous_SNV CTNND2:NM_001332:exon12:c.C2148T:p.T716T

EPHA3 185 CIN III No 3 89498427 89498427 A G nonsynonymous_SNV EPHA3:NM_005233:exon14:c.A2399G:p.K800R

MAP3K1 185 CIN III No 5 56178195 56178195 C T synonymous_SNV MAP3K1:NM_005921:exon14:c.C3168T:p.N1056N

PIAS4 185 CIN III No 19 4037682 4037682 G C nonsynonymous_SNV PIAS4:NM_015897:exon11:c.G1342C:p.G448R

PTPN9 185 CIN III No 15 75871110 75871110 G T nonsynonymous_SNV PTPN9:NM_002833:exon1:c.C8A:p.P3H

PTPRC 185 CIN III No 1 198678876 198678876 A G nonsynonymous_SNV PTPRC:NM_080921:exon8:c.A611G:p.Y204C

PTPRD 185 CIN III No 9 8449821 8449821 C A nonsynonymous_SNV PTPRD:NM_001171025:exon16:c.G2629T:p.D877Y

PTPRU 185 CIN III No 1 29585224 29585224 C T nonsynonymous_SNV PTPRU:NM_001195001:exon3:c.C413T:p.S138F

RALGDS 185 CIN III No 9 135987498 135987498 G A synonymous_SNV RALGDS:NM_001042368:exon2:c.C60T:p.V20V

SMAD4 185 CIN III No 18 48604655 48604655 G C nonsynonymous_SNV SMAD4:NM_005359:exon12:c.G1477C:p.D493H

STPG2 185 CIN III No 4 99064226 99064226 A G nonsynonymous_SNV STPG2:NM_174952:exon1:c.T76C:p.Y26H

TCF7L1 185 CIN III No 2 85529655 85529655 A T nonsynonymous_SNV TCF7L1:NM_031283:exon5:c.A574T:p.T192S

TP53 185 CIN III No 17 7577124 7577124 C T nonsynonymous_SNV TP53:NM_001126115:exon4:c.G418A:p.V140M

TYK2 185 CIN III No 19 10468695 10468695 G A synonymous_SNV TYK2:NM_003331:exon16:c.C2295T:p.G765G

APC 187 CIN III No 5 112173917 112173917 C T stopgain_SNV APC:NM_001127511:exon14:c.C2572T:p.R858X

CHD8 187 CIN III No 14 21868229 21868229 C T synonymous_SNV CHD8:NM_001170629:exon24:c.G4728A:p.K1576K

DPP10 187 CIN III No 2 116525948 116525948 G T stopgain_SNV DPP10:NM_001004360:exon13:c.G1168T:p.E390X FBXW7 187 CIN III No 4 153247289 153247289 G A nonsynonymous_SNV FBXW7:NM_001013415:exon9:c.C1159T:p.R387C

FTCD 187 CIN III No 21 47574178 47574178 G A synonymous_SNV FTCD:NM_006657:exon2:c.C123T:p.G41G

HCK 187 CIN III No 20 30689216 30689216 G A nonsynonymous_SNV HCK:NM_001172129:exon13:c.G1412A:p.R471H

KRAS 187 CIN III No 12 25398284 25398284 C A nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35T:p.G12V

SMAD4 187 CIN III No 18 48591919 48591919 G A nonsynonymous_SNV SMAD4:NM_005359:exon9:c.G1082A:p.R361H

TP53 187 CIN III No 17 7574003 7574003 G A stopgain_SNV TP53:NM_001126115:exon6:c.C628T:p.R210X

AKT1 189 MSI-L III No 14 105236689 105236689 C T nonsynonymous_SNV AKT1:NM_001014431:exon14:c.G1432A:p.G478S

APC 189 MSI-L III No 5 112175676 112175679 AGAG - frameshift_deletion APC:NM_001127511:exon14:c.4331_4334del:p.1444_1445del

APC 189 MSI-L III No 5 112174286 112174286 C T stopgain_SNV APC:NM_001127511:exon14:c.C2941T:p.Q981X

BTK 189 MSI-L III No X 100612520 100612520 G A nonsynonymous_SNV BTK:NM_000061:exon13:c.C1154T:p.P385L

CACNA1B 189 MSI-L III No 9 140968523 140968523 G T splicing mutation CACNA1B(NM_000718:exon33:c.4857+5G>T

CACNA1I 189 MSI-L III No 22 40042606 40042606 C T synonymous_SNV CACNA1I:NM_001003406:exon8:c.C1182T:p.L394L

CACNA1S 189 MSI-L III No 1 201061109 201061109 C G nonsynonymous_SNV CACNA1S:NM_000069:exon4:c.G532C:p.G178R

ITPR1 189 MSI-L III No 3 4558238 4558238 A T synonymous_SNV ITPR1:NM_001099952:exon3:c.A63T:p.G21G

PLCG1 189 MSI-L III No 20 39794366 39794366 C T nonsynonymous_SNV PLCG1:NM_002660:exon16:c.C1699T:p.R567C

TP53 189 MSI-L III No 17 7578406 7578406 C T nonsynonymous_SNV TP53:NM_001126115:exon1:c.G128A:p.R43H

TP53 189 MSI-L III No 17 7578449 7578449 C T nonsynonymous_SNV TP53:NM_001126115:exon1:c.G85A:p.A29T

ZAP70 189 MSI-L III No 2 98340596 98340596 C A nonsynonymous_SNV ZAP70:NM_001079:exon3:c.C97A:p.L33I

EPHA6 191 CIN IV Yes, at diagnosis 3 97356888 97356888 G A nonsynonymous_SNV EPHA6:NM_173655:exon12:c.G922A:p.V308M

FBXW7 191 CIN IV Yes, at diagnosis 4 153250833 153250833 G A synonymous_SNV FBXW7:NM_001013415:exon7:c.C873T:p.V291V

KAT7 191 CIN IV Yes, at diagnosis 17 47903382 47903382 G A nonsynonymous_SNV KAT7:NM_001199158:exon10:c.G994A:p.E332K

NRAS 191 CIN IV Yes, at diagnosis 1 115258745 115258745 C G nonsynonymous_SNV NRAS:NM_002524:exon2:c.G37C:p.G13R

PDGFRA 191 CIN IV Yes, at diagnosis 4 55138642 55138642 C T nonsynonymous_SNV PDGFRA:NM_006206:exon9:c.C1319T:p.T440M

PLCG1 191 CIN IV Yes, at diagnosis 20 39794322 39794322 A C nonsynonymous_SNV PLCG1:NM_002660:exon16:c.A1655C:p.H552P

PTPRS 191 CIN IV Yes, at diagnosis 19 5223175 5223175 C T synonymous_SNV PTPRS:NM_130854:exon14:c.G2562A:p.T854T

TP53 191 CIN IV Yes, at diagnosis 17 7577022 7577022 G A stopgain_SNV TP53:NM_001126115:exon4:c.C520T:p.R174X

APC 193 CIN IV Yes, at diagnosis 5 112128143 112128143 C T stopgain_SNV APC:NM_000038:exon7:c.C646T:p.R216X

ARID1A 193 CIN IV Yes, at diagnosis 1 27056214 27056214 C T stopgain_SNV ARID1A:NM_006015:exon2:c.C1210T:p.Q404X

BMX 193 CIN IV Yes, at diagnosis X 15574208 15574208 C T nonsynonymous_SNV BMX:NM_001721:exon19:c.C1966T:p.R656C

PTPRT 193 CIN IV Yes, at diagnosis 20 40743914 40743914 G A synonymous_SNV PTPRT:NM_007050:exon22:c.C3024T:p.Y1008Y

RAP1GDS1 193 CIN IV Yes, at diagnosis 4 99313184 99313184 C G nonsynonymous_SNV RAP1GDS1:NM_001100428:exon5:c.C446G:p.A149G

SMURF2 193 CIN IV Yes, at diagnosis 17 62574681 62574681 C T synonymous_SNV SMURF2:NM_022739:exon9:c.G786A:p.T262T

TCF7L2 193 CIN IV Yes, at diagnosis 10 114710532 114710532 G - frameshift_deletion TCF7L2:NM_001146274:exon1:c.17delG:p.G6fs

TP53 193 CIN IV Yes, at diagnosis 17 7578406 7578406 C T nonsynonymous_SNV TP53:NM_001126115:exon1:c.G128A:p.R43H APC 195 CIN IV Yes, at diagnosis 5 112174384 112174384 T G stopgain_SNV APC:NM_001127511:exon14:c.T3039G:p.Y1013X

CHD6 195 CIN IV Yes, at diagnosis 20 40052155 40052155 C T nonsynonymous_SNV CHD6:NM_032221:exon30:c.G4532A:p.R1511H

DAXX 195 CIN IV Yes, at diagnosis 6 33288984 33288984 G A nonsynonymous_SNV DAXX:NM_001254717:exon2:c.C343T:p.R115C

ERBB4 195 CIN IV Yes, at diagnosis 2 212293205 212293205 G A nonsynonymous_SNV ERBB4:NM_001042599:exon22:c.C2647T:p.P883S

NFKBIZ 195 CIN IV Yes, at diagnosis 3 101572525 101572525 - GT frameshift_insertion NFKBIZ:NM_031419:exon5:c.1155_1156insGT:p.M385fs

PIK3CA 195 CIN IV Yes, at diagnosis 3 178936095 178936095 A G nonsynonymous_SNV PIK3CA:NM_006218:exon10:c.A1637G:p.Q546R

PLCG2 195 CIN IV Yes, at diagnosis 16 81914541 81914541 G A synonymous_SNV PLCG2:NM_002661:exon8:c.G675A:p.S225S

SMAD4 195 CIN IV Yes, at diagnosis 18 48591919 48591919 G A nonsynonymous_SNV SMAD4:NM_005359:exon9:c.G1082A:p.R361H

TP53 195 CIN IV Yes, at diagnosis 17 7577574 7577574 T C nonsynonymous_SNV TP53:NM_001126115:exon3:c.A311G:p.Y104C

APC 197 CIN IV Yes, at diagnosis 5 112174694 112174695 TA - frameshift_deletion APC:NM_001127511:exon14:c.3349_3350del:p.1117_1117del

APC 197 CIN IV Yes, at diagnosis 5 112175248 112175248 T - frameshift_deletion APC:NM_001127511:exon14:c.3903delT:p.P1301fs

CACNA1H 197 CIN IV Yes, at diagnosis 16 1254206 1254206 C T synonymous_SNV CACNA1H:NM_001005407:exon10:c.C2199T:p.D733D

EPHB1 197 CIN IV Yes, at diagnosis 3 134670340 134670340 G A nonsynonymous_SNV EPHB1:NM_004441:exon3:c.G251A:p.R84H

APC 199 CIN IV Yes, at diagnosis 5 112174159 112174159 C G stopgain_SNV APC:NM_001127511:exon14:c.C2814G:p.Y938X

CACNB2 199 CIN IV Yes, at diagnosis 10 18828567 18828567 C T nonsynonymous_SNV CACNB2:NM_000724:exon13:c.C1732T:p.R578C

EPHA2 199 CIN IV Yes, at diagnosis 1 16464590 16464590 C T nonsynonymous_SNV EPHA2:NM_004431:exon5:c.G1070A:p.R357H

EPHA5 199 CIN IV Yes, at diagnosis 4 66230818 66230818 C T nonsynonymous_SNV EPHA5:NM_182472:exon11:c.G2087A:p.R696H

EPHA8 199 CIN IV Yes, at diagnosis 1 22903062 22903062 G A nonsynonymous_SNV EPHA8:NM_001006943:exon3:c.G512A:p.R171H

FNDC1 199 CIN IV Yes, at diagnosis 6 159653362 159653362 G A synonymous_SNV FNDC1:NM_032532:exon11:c.G1818A:p.T606T

ITPR1 199 CIN IV Yes, at diagnosis 3 4816974 4816974 G A nonsynonymous_SNV ITPR1:NM_002222:exon43:c.G5839A:p.E1947K

ITPR1 199 CIN IV Yes, at diagnosis 3 4817005 4817005 G A nonsynonymous_SNV ITPR1:NM_002222:exon43:c.G5870A:p.G1957E

RYR3 199 CIN IV Yes, at diagnosis 15 33855189 33855189 G A nonsynonymous_SNV RYR3:NM_001036:exon11:c.G1124A:p.R375H

SMAD4 199 CIN IV Yes, at diagnosis 18 48584593 48584593 C T stopgain_SNV SMAD4:NM_005359:exon6:c.C766T:p.Q256X

TP53 199 CIN IV Yes, at diagnosis 17 7577538 7577538 C T nonsynonymous_SNV TP53:NM_001126115:exon3:c.G347A:p.R116Q

UCKL1 199 CIN IV Yes, at diagnosis 20 62576026 62576026 C T nonsynonymous_SNV UCKL1:NM_001193379:exon6:c.G671A:p.R224H

CACNA2D2 201 CIN IV Yes, at diagnosis 3 50414939 50414939 C T nonsynonymous_SNV CACNA2D2:NM_001005505:exon17:c.G1585A:p.V529M

GNAS 201 CIN IV Yes, at diagnosis 20 57415512 57415512 C T synonymous_SNV GNAS:NM_016592:exon1:c.C351T:p.S117S

GNAS 201 CIN IV Yes, at diagnosis 20 57485063 57485063 G A synonymous_SNV GNAS:NM_001077489:exon10:c.G852A:p.E284E

INSRR 201 CIN IV Yes, at diagnosis 1 156814284 156814284 C T nonsynonymous_SNV INSRR:NM_014215:exon14:c.G2707A:p.D903N

SMAD4 201 CIN IV Yes, at diagnosis 18 48604836 48604836 G C stoploss_SNV SMAD4:NM_005359:exon12:c.G1658C:p.X553S

TP53 201 CIN IV Yes, at diagnosis 17 7578413 7578413 C A nonsynonymous_SNV TP53:NM_001126115:exon1:c.G121T:p.V41L

AATK 203 CIN IV Yes, at diagnosis 17 79096258 79096258 G A nonsynonymous_SNV AATK:NM_004920:exon10:c.C1169T:p.T390M

ACVRL1 203 CIN IV Yes, at diagnosis 12 52306960 52306960 C T nonsynonymous_SNV ACVRL1:NM_001077401:exon2:c.C139T:p.R47W

AMT 203 CIN IV Yes, at diagnosis 3 49459688 49459688 G A nonsynonymous_SNV AMT:NM_000481:exon2:c.C107T:p.T36I AP4E1 203 CIN IV Yes, at diagnosis 15 51293339 51293340 CT - frameshift_deletion AP4E1:NM_001252127:exon20:c.2987_2988del:p.996_996del

APC 203 CIN IV Yes, at diagnosis 5 112175390 112175390 C T stopgain_SNV APC:NM_001127511:exon14:c.C4045T:p.Q1349X

CACNA1B 203 CIN IV Yes, at diagnosis 9 140846732 140846732 G A nonsynonymous_SNV CACNA1B:NM_000718:exon7:c.G973A:p.D325N

CACNB2 203 CIN IV Yes, at diagnosis 10 18828268 18828268 C T nonsynonymous_SNV CACNB2:NM_000724:exon13:c.C1433T:p.S478F

DPF3 203 CIN IV Yes, at diagnosis 14 73238597 73238597 C T nonsynonymous_SNV DPF3:NM_012074:exon2:c.G37A:p.G13R

EZH2 203 CIN IV Yes, at diagnosis 7 148514318 148514318 C A nonsynonymous_SNV EZH2:NM_152998:exon10:c.G1274T:p.R425I

GRIN2D 203 CIN IV Yes, at diagnosis 19 48945610 48945610 C T nonsynonymous_SNV GRIN2D:NM_000836:exon12:c.C2644T:p.R882C

JMJD1C 203 CIN IV Yes, at diagnosis 10 64967272 64967272 G C nonsynonymous_SNV JMJD1C:NM_004241:exon7:c.C3500G:p.S1167C

MAP3K1 203 CIN IV Yes, at diagnosis 5 56171077 56171077 - TGCA frameshift_insertion MAP3K1:NM_005921:exon10:c.1905_1906insTGCA:p.C635fs

MSH6 203 CIN IV Yes, at diagnosis 2 48030689 48030689 G C nonsynonymous_SNV MSH6:NM_000179:exon5:c.G3303C:p.K1101N

PTPRQ 203 CIN IV Yes, at diagnosis 12 81014009 81014009 C A synonymous_SNV PTPRQ:NM_001145026:exon29:c.C4950A:p.G1650G

RYR3 203 CIN IV Yes, at diagnosis 15 33872187 33872187 C T nonsynonymous_SNV RYR3:NM_001036:exon13:c.C1279T:p.R427C

SKI 203 CIN IV Yes, at diagnosis 1 2160764 2160764 A T nonsynonymous_SNV SKI:NM_003036:exon1:c.A559T:p.N187Y

TP53 203 CIN IV Yes, at diagnosis 17 7578542 7578542 G A nonsynonymous_SNV TP53:NM_001126118:exon4:c.C271T:p.L91F

ZNF521 203 CIN IV Yes, at diagnosis 18 22806907 22806907 C A synonymous_SNV ZNF521:NM_015461:exon4:c.G975T:p.L325L

ABL2 1612_T MSI-H II No 1 179087847 179087847 G A synonymous_SNV ABL2:NM_001136001:exon6:c.C1035T:p.Y345Y

AKAP5 1612_T MSI-H II No 14 64935551 64935551 G T nonsynonymous_SNV AKAP5:NM_004857:exon2:c.G439T:p.D147Y

ARID1A 1612_T MSI-H II No 1 27094360 27094360 G T nonsynonymous_SNV ARID1A:NM_006015:exon11:c.G3068T:p.W1023L

ARID2 1612_T MSI-H II No 12 46244192 46244192 G T nonsynonymous_SNV ARID2:NM_152641:exon15:c.G2286T:p.L762F

CHD1 1612_T MSI-H II No 5 98212153 98212153 C A nonsynonymous_SNV CHD1:NM_001270:exon23:c.G3347T:p.R1116L

EP300 1612_T MSI-H II No 22 41573258 41573258 - G frameshift_insertion EP300:NM_001429:exon31:c.5543_5544insG:p.P1848fs

IRS1 1612_T MSI-H II No 2 227662551 227662551 G A stopgain_SNV IRS1:NM_005544:exon1:c.C904T:p.R302X

KDM5C 1612_T MSI-H II No X 53222356 53222356 G T synonymous_SNV KDM5C:NM_004187:exon26:c.C4476A:p.V1492V

RYR2 1612_T MSI-H II No 1 237862309 237862309 C A nonsynonymous_SNV RYR2:NM_001035:exon64:c.C9112A:p.Q3038K

TRRAP 1612_T MSI-H II No 7 98535395 98535395 G A synonymous_SNV TRRAP:NM_001244580:exon30:c.G4356A:p.T1452T

APC 16266_T CIN III Yes 5 112173704 112173704 C T stopgain_SNV APC:NM_001127511:exon14:c.C2359T:p.R787X

ARID1B 16266_T CIN III Yes 6 157100396 157100396 - CG frameshift_insertion ARID1B:NM_017519:exon1:c.1333_1334insCG:p.A445fs

ARID1B 16266_T CIN III Yes 6 157100397 157100397 - C frameshift_insertion ARID1B:NM_017519:exon1:c.1334dupC:p.A445fs

CACNA1B 16266_T CIN III Yes 9 140772403 140772403 C T synonymous_SNV CACNA1B:NM_000718:exon1:c.C18T:p.D6D

DPP10 16266_T CIN III Yes 2 116593815 116593815 C T nonsynonymous_SNV DPP10:NM_001004360:exon22:c.C2012T:p.T671I

EPHA2 16266_T CIN III Yes 1 16464673 16464673 G A synonymous_SNV EPHA2:NM_004431:exon5:c.C987T:p.P329P

EPHA6 16266_T CIN III Yes 3 97356879 97356879 C G nonsynonymous_SNV EPHA6:NM_173655:exon12:c.C913G:p.L305V

IRS2 16266_T CIN III Yes 13 110435615 110435615 - G frameshift_insertion IRS2:NM_003749:exon1:c.2786dupC:p.A929fs

IRS2 16266_T CIN III Yes 13 110435157 110435157 T G nonsynonymous_SNV IRS2:NM_003749:exon1:c.A3244C:p.T1082P MLL4 16266_T CIN III Yes 19 36211375 36211376 AA - frameshift_deletion MLL4:NM_014727:exon3:c.1126_1127del:p.376_376del

MLL4 16266_T CIN III Yes 19 36211378 36211378 G - frameshift_deletion MLL4:NM_014727:exon3:c.1129delG:p.E377fs

MTOR 16266_T CIN III Yes 1 11190804 11190804 C T nonsynonymous_SNV MTOR:NM_004958:exon39:c.G5395A:p.E1799K

PIAS1 16266_T CIN III Yes 15 68438994 68438994 G A nonsynonymous_SNV PIAS1:NM_016166:exon6:c.G784A:p.V262I

PTPRT 16266_T CIN III Yes 20 40735458 40735458 G A nonsynonymous_SNV PTPRT:NM_007050:exon24:c.C3358T:p.R1120W

RET 16266_T CIN III Yes 10 43572779 43572779 G A nonsynonymous_SNV RET:NM_020630:exon1:c.G73A:p.V25M

SLC25A31 16266_T CIN III Yes 4 128665844 128665844 C A nonsynonymous_SNV SLC25A31:NM_031291:exon2:c.C250A:p.R84S

TP53 16266_T CIN III Yes 17 7578212 7578212 G A stopgain_SNV TP53:NM_001126115:exon2:c.C241T:p.R81X

APC 16982_T CIN II No 5 112175390 112175390 C T stopgain_SNV APC:NM_001127511:exon14:c.C4045T:p.Q1349X

APC 16982_T CIN II No 5 112151261 112151261 C T stopgain_SNV APC:NM_001127511:exon7:c.C850T:p.R284X

ARID1B 16982_T CIN II No 6 157100396 157100396 - CG frameshift_insertion ARID1B:NM_017519:exon1:c.1333_1334insCG:p.A445fs

ARID1B 16982_T CIN II No 6 157100397 157100397 - C frameshift_insertion ARID1B:NM_017519:exon1:c.1334dupC:p.A445fs

DRD2 16982_T CIN II No 11 113288845 113288845 C T stopgain_SNV DRD2:NM_000795:exon3:c.G299A:p.W100X

GRIN2A 16982_T CIN II No 16 9857957 9857957 C T synonymous_SNV GRIN2A:NM_001134407:exon13:c.G3444A:p.P1148P

ITPR1 16982_T CIN II No 3 4735229 4735229 A T nonsynonymous_SNV ITPR1:NM_001168272:exon32:c.A4040T:p.Q1347L

KAT6B 16982_T CIN II No 10 76789108 76789108 G T nonsynonymous_SNV KAT6B:NM_001256468:exon18:c.G3977T:p.G1326V

MERTK 16982_T CIN II No 2 112686782 112686782 G A synonymous_SNV MERTK:NM_006343:exon2:c.G147A:p.P49P

MTHFR 16982_T CIN II No 1 11851343 11851343 G A nonsynonymous_SNV MTHFR:NM_005957:exon11:c.C1673T:p.A558V

PIK3C2B 16982_T CIN II No 1 204416676 204416676 T A stopgain_SNV PIK3C2B:NM_002646:exon16:c.A2377T:p.K793X

SMARCA2 16982_T CIN II No 9 2039656 2039656 T A synonymous_SNV SMARCA2:NM_003070:exon4:c.T546A:p.L182L

TP53 16982_T CIN II No 17 7578395 7578395 G C nonsynonymous_SNV TP53:NM_001126115:exon1:c.C139G:p.H47D

AATK 18366_T MSI-H III No 17 79093745 79093745 C G nonsynonymous_SNV AATK:NM_004920:exon11:c.G3565C:p.A1189P

AATK 18366_T MSI-H III No 17 79094280 79094280 C T synonymous_SNV AATK:NM_004920:exon10:c.G3147A:p.A1049A

ACVR2A 18366_T MSI-H III No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

ADAMTSL3 18366_T MSI-H III No 15 84566735 84566735 C T synonymous_SNV ADAMTSL3:NM_207517:exon14:c.C1593T:p.P531P

AKAP13 18366_T MSI-H III No 15 86123258 86123258 T C synonymous_SNV AKAP13:NM_006738:exon7:c.T1959C:p.C653C

AKAP9 18366_T MSI-H III No 7 91621508 91621508 C T nonsynonymous_SNV AKAP9:NM_005751:exon4:c.C388T:p.P130S

APC 18366_T MSI-H III No 5 112175985 112175985 A T nonsynonymous_SNV APC:NM_001127511:exon14:c.A4640T:p.D1547V

APC2 18366_T MSI-H III No 19 1457110 1457110 C A nonsynonymous_SNV APC2:NM_005883:exon9:c.C1075A:p.P359T

ARID1B 18366_T MSI-H III No 6 157469991 157469991 C T nonsynonymous_SNV ARID1B:NM_017519:exon8:c.C2746T:p.P916S

ATP2A1 18366_T MSI-H III No 16 28913647 28913647 C - frameshift_deletion ATP2A1:NM_004320:exon17:c.2464delC:p.R822fs

ATP2B3 18366_T MSI-H III No X 152815530 152815530 C T nonsynonymous_SNV ATP2B3:NM_001001344:exon10:c.C1609T:p.R537C

ATR 18366_T MSI-H III No 3 142274749 142274749 T - frameshift_deletion ATR:NM_001184:exon10:c.2311delA:p.K771fs

ATRX 18366_T MSI-H III No X 76907782 76907784 TCC - nonframeshift_deletion ATRX:NM_138270:exon14:c.4263_4265del:p.1421_1422del AXIN2 18366_T MSI-H III No 17 63532591 63532591 C - frameshift_deletion AXIN2:NM_004655:exon8:c.1988delG:p.W663fs

BAZ2B 18366_T MSI-H III No 2 160285739 160285739 G A nonsynonymous_SNV BAZ2B:NM_013450:exon11:c.C2227T:p.R743C

BAZ2B 18366_T MSI-H III No 2 160242861 160242861 - T splicing mutation BAZ2B(NM_013450:exon23:c.3471+3->A)

BRAF 18366_T MSI-H III No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1A 18366_T MSI-H III No 19 13318773 13318773 G - frameshift_deletion CACNA1A:NM_001127222:exon47:c.6875delC:p.T2292fs

CACNA1B 18366_T MSI-H III No 9 140917739 140917739 G A synonymous_SNV CACNA1B:NM_000718:exon19:c.G2544A:p.P848P

CACNA1C 18366_T MSI-H III No 12 2224501 2224501 C T nonsynonymous_SNV CACNA1C:NM_000719:exon2:c.C161T:p.A54V

CACNA1G 18366_T MSI-H III No 17 48703874 48703874 G A nonsynonymous_SNV CACNA1G:NM_198387:exon34:c.G6515A:p.G2172E

CACNB1 18366_T MSI-H III No 17 37342239 37342239 C T synonymous_SNV CACNB1:NM_199247:exon7:c.G747A:p.P249P

CASQ1 18366_T MSI-H III No 1 160171148 160171148 C T synonymous_SNV CASQ1:NM_001231:exon11:c.C1173T:p.D391D

CDH20 18366_T MSI-H III No 18 59157988 59157988 G A nonsynonymous_SNV CDH20:NM_031891:exon1:c.G202A:p.V68I

CHD4 18366_T MSI-H III No 12 6711318 6711318 - C frameshift_insertion CHD4:NM_001273:exon4:c.246dupG:p.L82fs

CHD4 18366_T MSI-H III No 12 6711147 6711147 C A nonsynonymous_SNV CHD4:NM_001273:exon4:c.G417T:p.E139D

CHD7 18366_T MSI-H III No 8 61655491 61655491 A G synonymous_SNV CHD7:NM_017780:exon2:c.A1500G:p.Q500Q

CTNND1 18366_T MSI-H III No 11 57564389 57564389 T C nonsynonymous_SNV CTNND1:NM_001085469:exon3:c.T578C:p.L193P

CYLD 18366_T MSI-H III No 16 50813674 50813674 G A nonsynonymous_SNV CYLD:NM_001042355:exon8:c.G1228A:p.E410K

DAXX 18366_T MSI-H III No 6 33288180 33288180 C T nonsynonymous_SNV DAXX:NM_001254717:exon3:c.G1003A:p.E335K

DNAH3 18366_T MSI-H III No 16 21049105 21049105 G A nonsynonymous_SNV DNAH3:NM_017539:exon34:c.C4928T:p.A1643V

DNMT3B 18366_T MSI-H III No 20 31394033 31394033 A G nonsynonymous_SNV DNMT3B:NM_175848:exon21:c.A2260G:p.I754V

DOCK3 18366_T MSI-H III No 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

EP300 18366_T MSI-H III No 22 41513225 41513225 A G synonymous_SNV EP300:NM_001429:exon2:c.A129G:p.L43L

EP400 18366_T MSI-H III No 12 132505774 132505774 C - frameshift_deletion EP400:NM_015409:exon23:c.4598delC:p.P1533fs

EP400 18366_T MSI-H III No 12 132547096 132547097 GC - frameshift_deletion EP400:NM_015409:exon47:c.8184_8185del:p.2728_2729del

EP400 18366_T MSI-H III No 12 132547099 132547099 G - frameshift_deletion EP400:NM_015409:exon47:c.8187delG:p.Q2729fs

EPHA10 18366_T MSI-H III No 1 38197144 38197144 C - frameshift_deletion EPHA10:NM_001099439:exon7:c.1602delG:p.P534fs

EPHA10 18366_T MSI-H III No 1 38188736 38188736 G A nonsynonymous_SNV EPHA10:NM_001099439:exon10:c.C1937T:p.T646M

EPHA2 18366_T MSI-H III No 1 16474982 16474982 - C frameshift_insertion EPHA2:NM_004431:exon3:c.714dupG:p.P238fs

EPHA5 18366_T MSI-H III No 4 66509090 66509090 - T frameshift_insertion EPHA5:NM_004439:exon2:c.237dupA:p.P79fs

EPHA7 18366_T MSI-H III No 6 94068117 94068117 C T nonsynonymous_SNV EPHA7:NM_004440:exon4:c.G845A:p.G282E

ERBB2 18366_T MSI-H III No 17 37873704 37873704 C T synonymous_SNV ERBB2:NM_004448:exon15:c.C1869T:p.C623C

ERBB3 18366_T MSI-H III No 12 56494996 56494996 G T nonsynonymous_SNV ERBB3:NM_001982:exon27:c.G3353T:p.R1118L

FBXW7 18366_T MSI-H III No 4 153249366 153249366 - T frameshift_insertion FBXW7:NM_001013415:exon8:c.1058dupA:p.E353fs

FBXW7 18366_T MSI-H III No 4 153268144 153268144 G A stopgain_SNV FBXW7:NM_001013415:exon3:c.C310T:p.R104X

FLT1 18366_T MSI-H III No 13 28942784 28942784 C T synonymous_SNV FLT1:NM_001160030:exon15:c.G2133A:p.T711T GNA15 18366_T MSI-H III No 19 3151786 3151786 C A synonymous_SNV GNA15:NM_002068:exon4:c.C567A:p.T189T

GRIN2D 18366_T MSI-H III No 19 48946829 48946829 G A nonsynonymous_SNV GRIN2D:NM_000836:exon13:c.G3646A:p.A1216T

HDAC2 18366_T MSI-H III No 6 114264524 114264524 T - frameshift_deletion HDAC2:NM_001527:exon12:c.1369delA:p.K457fs

HDAC4 18366_T MSI-H III No 2 240056010 240056010 C T nonsynonymous_SNV HDAC4:NM_006037:exon11:c.G1225A:p.A409T

IRS1 18366_T MSI-H III No 2 227660213 227660213 C T nonsynonymous_SNV IRS1:NM_005544:exon1:c.G3242A:p.R1081H

IRS1 18366_T MSI-H III No 2 227660772 227660772 C T nonsynonymous_SNV IRS1:NM_005544:exon1:c.G2683A:p.E895K

IRS1 18366_T MSI-H III No 2 227662009 227662009 G A synonymous_SNV IRS1:NM_005544:exon1:c.C1446T:p.H482H

ITPR1 18366_T MSI-H III No 3 4774858 4774858 C T synonymous_SNV ITPR1:NM_002222:exon39:c.C5118T:p.G1706G

ITPR2 18366_T MSI-H III No 12 26810738 26810738 A G synonymous_SNV ITPR2:NM_002223:exon18:c.T2094C:p.I698I

ITPR3 18366_T MSI-H III No 6 33652652 33652652 G A nonsynonymous_SNV ITPR3:NM_002224:exon39:c.G5239A:p.E1747K

JAK1 18366_T MSI-H III No 1 65330636 65330636 T - frameshift_deletion JAK1:NM_002227:exon8:c.1010delA:p.E337fs

JAK3 18366_T MSI-H III No 19 17941313 17941313 G A nonsynonymous_SNV JAK3:NM_000215:exon22:c.C3095T:p.A1032V

JMJD1C 18366_T MSI-H III No 10 64952706 64952706 T - frameshift_deletion JMJD1C:NM_004241:exon13:c.5357delA:p.E1786fs

JMJD8 18366_T MSI-H III No 16 734282 734282 A G nonsynonymous_SNV JMJD8:NM_001005920:exon1:c.T101C:p.L34P

KAT6B 18366_T MSI-H III No 10 76735495 76735495 A - frameshift_deletion KAT6B:NM_001256468:exon8:c.1400delA:p.K467fs

KDM5A 18366_T MSI-H III No 12 416960 416960 T - frameshift_deletion KDM5A:NM_001042603:exon23:c.3590delA:p.Q1197fs

KDM5C 18366_T MSI-H III No X 53227955 53227955 G A nonsynonymous_SNV KDM5C:NM_001146702:exon14:c.C2158T:p.R720W

KIT 18366_T MSI-H III No 4 55575638 55575638 C T synonymous_SNV KIT:NM_000222:exon7:c.C1164T:p.G388G

MAP3K14 18366_T MSI-H III No 17 43344864 43344864 C T unknown UNKNOWN

MAPK1 18366_T MSI-H III No 22 22127165 22127165 G A synonymous_SNV MAPK1:NM_002745:exon7:c.C963T:p.D321D

MAPK10 18366_T MSI-H III No 4 86988997 86988997 G A nonsynonymous_SNV MAPK10:NM_138981:exon5:c.C479T:p.A160V

MAPK11 18366_T MSI-H III No 22 50705419 50705419 G A nonsynonymous_SNV MAPK11:NM_002751:exon7:c.C554T:p.T185M

MAPK13 18366_T MSI-H III No 6 36104454 36104454 C T stopgain_SNV MAPK13:NM_002754:exon7:c.C517T:p.R173X

MAPK3 18366_T MSI-H III No 16 30129099 30129099 T C nonsynonymous_SNV MAPK3:NM_001040056:exon5:c.A667G:p.T223A

MAPK8 18366_T MSI-H III No 10 49609820 49609820 A G nonsynonymous_SNV MAPK8:NM_002750:exon1:c.A117G:p.I39M

MAPK8IP2 18366_T MSI-H III No 22 51042322 51042322 G A unknown UNKNOWN

MLH3 18366_T MSI-H III No 14 75514345 75514345 - T frameshift_insertion MLH3:NM_001040108:exon2:c.2014dupA:p.K672fs

MLL 18366_T MSI-H III No 11 118307400 118307400 C - frameshift_deletion MLL:NM_001197104:exon1:c.173delC:p.P58fs

MLL2 18366_T MSI-H III No 12 49434496 49434496 G - frameshift_deletion MLL2:NM_003482:exon31:c.7057delC:p.P2353fs

MLL3 18366_T MSI-H III No 7 151874156 151874156 T - frameshift_deletion MLL3:NM_170606:exon38:c.8382delA:p.P2794fs

MLL4 18366_T MSI-H III No 19 36223007 36223007 G - frameshift_deletion MLL4:NM_014727:exon27:c.5636delG:p.G1879fs

MMP2 18366_T MSI-H III No 16 55516968 55516968 C T nonsynonymous_SNV MMP2:NM_001127891:exon2:c.C151T:p.R51C

MSH6 18366_T MSI-H III No 2 48030647 48030647 C - frameshift_deletion MSH6:NM_000179:exon5:c.3261delC:p.P1087fs

MSH6 18366_T MSI-H III No 2 48025849 48025849 C T nonsynonymous_SNV MSH6:NM_000179:exon4:c.C727T:p.R243C MTR 18366_T MSI-H III No 1 237013640 237013640 C A splicing mutation MTR(NM_000254:exon16:c.1516-4C>A)

NAV3 18366_T MSI-H III No 12 78400221 78400221 G A synonymous_SNV NAV3:NM_014903:exon8:c.G903A:p.S301S

NR4A1 18366_T MSI-H III No 12 52450300 52450300 G C nonsynonymous_SNV NR4A1:NM_173157:exon4:c.G1029C:p.K343N

OTX2 18366_T MSI-H III No 14 57271024 57271024 G A nonsynonymous_SNV OTX2:NM_001270525:exon2:c.C155T:p.T52M

PAK4 18366_T MSI-H III No 19 39667282 39667282 G A nonsynonymous_SNV PAK4:NM_001014834:exon6:c.G953A:p.R318Q

PAK6 18366_T MSI-H III No 15 40566467 40566467 - A frameshift_insertion PAK6:NM_001276717:exon8:c.1868dupA:p.N623fs

PBRM1 18366_T MSI-H III No 3 52643686 52643686 G A nonsynonymous_SNV PBRM1:NM_018313:exon17:c.C2210T:p.T737I

PIK3C2B 18366_T MSI-H III No 1 204438078 204438078 G - frameshift_deletion PIK3C2B:NM_002646:exon3:c.853delC:p.P285fs

PIK3C2G 18366_T MSI-H III No 12 18491396 18491396 A - frameshift_deletion PIK3C2G:NM_004570:exon9:c.1309delA:p.I437fs

PIK3C2G 18366_T MSI-H III No 12 18524219 18524219 G A stopgain_SNV PIK3C2G:NM_004570:exon12:c.G1731A:p.W577X

PIK3CA 18366_T MSI-H III No 3 178952075 178952075 A T nonsynonymous_SNV p.N1044Y

PLCD1 18366_T MSI-H III No 3 38052046 38052046 C T synonymous_SNV PLCD1:NM_001130964:exon6:c.G861A:p.A287A

PMS2 18366_T MSI-H III No 7 6027164 6027164 T - frameshift_deletion PMS2:NM_000535:exon11:c.1232delA:p.E411fs

PRKAR1B 18366_T MSI-H III No 7 720287 720287 G - frameshift_deletion PRKAR1B:NM_001164758:exon3:c.254delC:p.T85fs

PRKDC 18366_T MSI-H III No 8 48805819 48805819 A G unknown UNKNOWN

PRKDC 18366_T MSI-H III No 8 48866919 48866919 T - unknown UNKNOWN

PTPN2 18366_T MSI-H III No 18 12859225 12859225 G A nonsynonymous_SNV PTPN2:NM_001207013:exon2:c.C98T:p.P33L

PTPN21 18366_T MSI-H III No 14 88946064 88946064 G - frameshift_deletion PTPN21:NM_007039:exon13:c.1711delC:p.P571fs

PTPN21 18366_T MSI-H III No 14 88946278 88946278 G A synonymous_SNV PTPN21:NM_007039:exon13:c.C1497T:p.H499H

PTPN3 18366_T MSI-H III No 9 112145804 112145804 G - frameshift_deletion PTPN3:NM_001145372:exon12:c.1285delC:p.P429fs

PTPN3 18366_T MSI-H III No 9 112151514 112151514 C T nonsynonymous_SNV PTPN3:NM_001145372:exon11:c.G1256A:p.R419Q

PTPRB 18366_T MSI-H III No 12 70965039 70965039 C T nonsynonymous_SNV PTPRB:NM_001206971:exon10:c.G2213A:p.R738H

PTPRS 18366_T MSI-H III No 19 5238992 5238992 G A nonsynonymous_SNV PTPRS:NM_130853:exon10:c.C1748T:p.A583V

PTPRS 18366_T MSI-H III No 19 5221096 5221096 C T nonsynonymous_SNV PTPRS:NM_130853:exon12:c.G2077A:p.G693S

PTPRS 18366_T MSI-H III No 19 5258031 5258031 G A stopgain_SNV PTPRS:NM_130853:exon6:c.C676T:p.R226X

PTPRU 18366_T MSI-H III No 1 29602045 29602045 C T synonymous_SNV PTPRU:NM_001195001:exon8:c.C1230T:p.N410N

PTPRU 18366_T MSI-H III No 1 29647253 29647253 G A synonymous_SNV PTPRU:NM_001195001:exon26:c.G3735A:p.T1245T

PTPRU 18366_T MSI-H III No 1 29606570 29606570 C T synonymous_SNV PTPRU:NM_001195001:exon11:c.C1785T:p.A595A

RASA1 18366_T MSI-H III No 5 86564392 86564392 C A nonsynonymous_SNV RASA1:NM_002890:exon1:c.C124A:p.L42M

RASA1 18366_T MSI-H III No 5 86669976 86669978 TTA - splicing mutation RASA1

RASGRF1 18366_T MSI-H III No 15 79382679 79382679 G A synonymous_SNV RASGRF1:NM_001145648:exon1:c.C162T:p.F54F

RASGRF2 18366_T MSI-H III No 5 80382745 80382745 G A nonsynonymous_SNV RASGRF2:NM_006909:exon9:c.G1363A:p.D455N

RRM2 18366_T MSI-H III No 2 10262776 10262776 - A frameshift_insertion RRM2:NM_001165931:exon1:c.31dupA:p.M11fs

RYR1 18366_T MSI-H III No 19 38976770 38976770 C T synonymous_SNV RYR1:NM_000540:exon34:c.C5475T:p.H1825H RYR1 18366_T MSI-H III No 19 38979834 38979834 C T synonymous_SNV RYR1:NM_000540:exon35:c.C5565T:p.G1855G

RYR2 18366_T MSI-H III No 1 237969502 237969502 T - frameshift_deletion RYR2:NM_001035:exon99:c.14217delT:p.F4739fs

RYR3 18366_T MSI-H III No 15 34102719 34102719 C T nonsynonymous_SNV RYR3:NM_001243996:exon70:c.C10051T:p.R3351W

RYR3 18366_T MSI-H III No 15 34150051 34150051 G A nonsynonymous_SNV RYR3:NM_001243996:exon98:c.G14063A:p.R4688H

RYR3 18366_T MSI-H III No 15 34152844 34152844 T C nonsynonymous_SNV RYR3:NM_001243996:exon100:c.T14333C:p.V4778A

RYR3 18366_T MSI-H III No 15 33825574 33825574 A G synonymous_SNV RYR3:NM_001036:exon5:c.A417G:p.L139L

SETD1B 18366_T MSI-H III No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

SHC1 18366_T MSI-H III No 1 154938495 154938495 C T synonymous_SNV SHC1:NM_001130040:exon10:c.G1314A:p.R438R

SLC25A31 18366_T MSI-H III No 4 128651936 128651936 C T splicing mutation SLC25A31(NM_031291:exon1:c.232+4C>T)

SMAD2 18366_T MSI-H III No 18 45368253 45368253 T C nonsynonymous_SNV SMAD2:NM_001135937:exon10:c.A1259G:p.D420G

SMARCA2 18366_T MSI-H III No 9 2058415 2058416 AG - frameshift_deletion SMARCA2:NM_003070:exon8:c.1472_1473del:p.491_491del

SMARCA2 18366_T MSI-H III No 9 2058418 2058418 A - frameshift_deletion SMARCA2:NM_003070:exon8:c.1475delA:p.K492fs

SMARCD2 18366_T MSI-H III No 17 61919882 61919882 C - frameshift_deletion SMARCD2:NM_001098426:exon1:c.153delG:p.V51fs

SMARCD2 18366_T MSI-H III No 17 61910680 61910680 C T nonsynonymous_SNV SMARCD2:NM_001098426:exon11:c.G1418A:p.R473H

SOCS2 18366_T MSI-H III No 12 93966751 93966751 G A synonymous_SNV SOCS2:NM_001270471:exon1:c.G78A:p.A26A

STAT5B 18366_T MSI-H III No 17 40370243 40370243 G - frameshift_deletion STAT5B:NM_012448:exon9:c.1095delC:p.N365fs

TCF7L2 18366_T MSI-H III No 10 114710516 114710516 A - frameshift_deletion TCF7L2:NM_001146274:exon1:c.1delA:p.M1fs

TCF7L2 18366_T MSI-H III No 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TGFBRAP1 18366_T MSI-H III No 2 105886007 105886007 G - frameshift_deletion TGFBRAP1:NM_001142621:exon11:c.2128delC:p.P710fs

TRDN 18366_T MSI-H III No 6 123759216 123759216 T - frameshift_deletion TRDN:NM_001251987:exon12:c.1046delA:p.E349fs

UCK2 18366_T MSI-H III No 1 165872509 165872509 G A nonsynonymous_SNV UCK2:NM_012474:exon5:c.G590A:p.C197Y

AKT1 19835_T CIN II No 14 105243024 105243024 T C nonsynonymous_SNV AKT1:NM_001014431:exon4:c.A259G:p.T87A

CACNA1E 19835_T CIN II No 1 181549881 181549881 C A nonsynonymous_SNV CACNA1E:NM_000721:exon6:c.C920A:p.T307N

FNDC1 19835_T CIN II No 6 159642716 159642716 C T stopgain_SNV FNDC1:NM_032532:exon6:c.C754T:p.R252X

IKBKAP 19835_T CIN II No 9 111644449 111644449 G A nonsynonymous_SNV IKBKAP:NM_003640:exon30:c.C3241T:p.L1081F

IRS2 19835_T CIN II No 13 110435615 110435615 - G frameshift_insertion IRS2:NM_003749:exon1:c.2786dupC:p.A929fs

KRAS 19835_T CIN II No 12 25398281 25398281 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G38A:p.G13D

MAPK13 19835_T CIN II No 6 36104466 36104466 G A nonsynonymous_SNV MAPK13:NM_002754:exon7:c.G529A:p.A177T

NF1 19835_T CIN II No 17 29652904 29652904 T G stopgain_SNV NF1:NM_000267:exon36:c.T4839G:p.Y1613X

PTPRT 19835_T CIN II No 20 40944359 40944359 T G splicing mutation PTPRT(NM_133170:exon13:c.2139+4A>C

SHC3 19835_T CIN II No 9 91793085 91793085 C G synonymous_SNV SHC3:NM_016848:exon1:c.G291C:p.S97S

SMAD4 19835_T CIN II No 18 48591888 48591888 G C nonsynonymous_SNV SMAD4:NM_005359:exon9:c.G1051C:p.D351H

TP53 19835_T CIN II No 17 7574018 7574018 G A nonsynonymous_SNV TP53:NM_001126115:exon6:c.C613T:p.R205C

TP53 19835_T CIN II No 17 7579312 7579312 C T synonymous_SNV TP53:NM_001126118:exon3:c.G258A:p.T86T AATK 20061_T CIN II Yes 17 79095642 79095642 G A synonymous_SNV AATK:NM_004920:exon10:c.C1785T:p.P595P

AXIN2 20061_T CIN II Yes 17 63554706 63554706 - C frameshift_insertion AXIN2:NM_004655:exon2:c.33dupG:p.P11fs

CTNNA3 20061_T CIN II Yes 10 67748466 67748466 C T nonsynonymous_SNV CTNNA3:NM_001127384:exon16:c.G2249A:p.R750Q

CTNND1 20061_T CIN II Yes 11 57569568 57569568 C A nonsynonymous_SNV CTNND1:NM_001085469:exon4:c.C1017A:p.D339E

HDAC11 20061_T CIN II Yes 3 13521852 13521852 G T splicing mutation HDAC11(NM_024827:exon1:c.2+3G>T)

KDM5A 20061_T CIN II Yes 12 416960 416960 - T frameshift_insertion KDM5A:NM_001042603:exon23:c.3590dupA:p.Q1197fs

PLCB3 20061_T CIN II Yes 11 64032544 64032544 C A nonsynonymous_SNV PLCB3:NM_001184883:exon21:c.C2573A:p.T858N

PTPRG 20061_T CIN II Yes 3 61975421 61975421 G A nonsynonymous_SNV PTPRG:NM_002841:exon3:c.G313A:p.D105N

RASA1 20061_T CIN II Yes 5 86627318 86627318 G C splicing mutation RASA1(NM_002890:exon2:c.692+1G>C

TP53 20061_T CIN II Yes 17 7577121 7577121 G A nonsynonymous_SNV TP53:NM_001126115:exon4:c.C421T:p.R141C

ACVR2A 20510_T MSI-H II No 2 148683693 148683693 A - frameshift_deletion ACVR2A:NM_001616:exon10:c.1310delA:p.K437fs

BMPR2 20510_T MSI-H II No 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

CHD8 20510_T MSI-H II No 14 21873910 21873910 C A nonsynonymous_SNV CHD8:NM_001170629:exon14:c.G3021T:p.K1007N

PIK3CA 20510_T MSI-H II No 3 178936092 178936092 A C nonsynonymous_SNV p.E545A

PLCG2 20510_T MSI-H II No 16 81944235 81944236 AG - frameshift_deletion PLCG2:NM_002661:exon18:c.1844_1845del:p.615_615del

SETD1B 20510_T MSI-H II No 12 122242665 122242665 C - frameshift_deletion SETD1B:NM_015048:exon1:c.22delC:p.H8fs

TGFBR2 20510_T MSI-H II No 3 30691881 30691881 A - frameshift_deletion TGFBR2:NM_003242:exon3:c.383delA:p.K128fs

ALK 3850_T CIN II No 2 29449830 29449830 C T nonsynonymous_SNV ALK:NM_004304:exon18:c.G3025A:p.D1009N

APC 3850_T CIN II No 5 112175639 112175639 C T stopgain_SNV APC:NM_001127511:exon14:c.C4294T:p.R1432X

CACNA1G 3850_T CIN II No 17 48646649 48646649 G A nonsynonymous_SNV CACNA1G:NM_001256324:exon3:c.G478A:p.V160I

CACNA1I 3850_T CIN II No 22 40082379 40082379 C T nonsynonymous_SNV CACNA1I:NM_001003406:exon36:c.C6536T:p.P2179L

FNDC1 3850_T CIN II No 6 159653964 159653964 C T nonsynonymous_SNV FNDC1:NM_032532:exon11:c.C2420T:p.T807M

NRAS 3850_T CIN II No 1 115256530 115256530 G T nonsynonymous_SNV NRAS:NM_002524:exon3:c.C181A:p.Q61K

PIK3R1 3850_T CIN II No 5 67589027 67589027 G A nonsynonymous_SNV PIK3R1:NM_001242466:exon2:c.G29A:p.R10K

PTPRM 3850_T CIN II No 18 8069993 8069993 G A splicing mutation PTPRM(NM_002845:exon8:c.1441+1G>A

SLC24A3 3850_T CIN II No 20 19261724 19261724 C T synonymous_SNV SLC24A3:NM_020689:exon2:c.C264T:p.T88T

STRADA 3850_T CIN II No 17 61804054 61804054 C T nonsynonymous_SNV STRADA:NM_001003787:exon3:c.G38A:p.R13Q

TP53 3850_T CIN II No 17 7578208 7578208 T C nonsynonymous_SNV TP53:NM_001126115:exon2:c.A245G:p.H82R

TSC2 3850_T CIN II No 16 2111887 2111887 G T stopgain_SNV TSC2:NM_000548:exon12:c.G1135T:p.E379X

AKAP3 4440_T CIN II No 12 4737680 4737680 G A nonsynonymous_SNV AKAP3:NM_006422:exon4:c.C388T:p.R130C

ALK 4440_T CIN II No 2 29754820 29754820 G T nonsynonymous_SNV ALK:NM_004304:exon4:c.C1115A:p.A372E

APC 4440_T CIN II No 5 112174116 112174116 - A frameshift_insertion APC:NM_001127511:exon14:c.2771dupA:p.N924fs

APC 4440_T CIN II No 5 112175639 112175639 C T stopgain_SNV APC:NM_001127511:exon14:c.C4294T:p.R1432X

CYLD 4440_T CIN II No 16 50816317 50816317 G C nonsynonymous_SNV CYLD:NM_001042355:exon10:c.G1757C:p.G586A DRD3 4440_T CIN II No 3 113847605 113847605 A G synonymous_SNV DRD3:NM_000796:exon7:c.T1161C:p.N387N

HCFC1 4440_T CIN II No X 153220355 153220355 C A nonsynonymous_SNV HCFC1:NM_005334:exon17:c.G3495T:p.Q1165H

KAT6B 4440_T CIN II No 10 76781905 76781905 - GAA nonframeshift_insertion KAT6B:NM_001256468:exon16:c.2739_2740insGAA:p.E913delinsEE

KRAS 4440_T CIN II No 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

PAK4 4440_T CIN II No 19 39663631 39663631 C T nonsynonymous_SNV PAK4:NM_001014832:exon3:c.C278T:p.S93L

STAT5B 4440_T CIN II No 17 40364019 40364019 A T nonsynonymous_SNV STAT5B:NM_012448:exon13:c.T1663A:p.W555R

TP53 4440_T CIN II No 17 7578413 7578413 C A nonsynonymous_SNV TP53:NM_001126115:exon1:c.G121T:p.V41L

APC 5126_T CIN II No 5 112164616 112164616 C T stopgain_SNV APC:NM_001127511:exon12:c.C1636T:p.R546X

EP400 5126_T CIN II No 12 132504668 132504668 G A nonsynonymous_SNV EP400:NM_015409:exon22:c.G4352A:p.R1451Q

IRS2 5126_T CIN II No 13 110437975 110437975 C - frameshift_deletion IRS2:NM_003749:exon1:c.426delG:p.L142fs

IRS2 5126_T CIN II No 13 110437989 110437989 C - frameshift_deletion IRS2:NM_003749:exon1:c.412delG:p.A138fs

IRS2 5126_T CIN II No 13 110437982 110437982 - G frameshift_insertion IRS2:NM_003749:exon1:c.419dupC:p.T140fs

JAK3 5126_T CIN II No 19 17955043 17955043 C T nonsynonymous_SNV JAK3:NM_000215:exon2:c.G184A:p.G62S

KRAS 5126_T CIN II No 12 25398285 25398285 C A nonsynonymous_SNV KRAS:NM_004985:exon2:c.G34T:p.G12C

PTPRF 5126_T CIN II No 1 44069403 44069403 C T synonymous_SNV PTPRF:NM_130440:exon15:c.C2553T:p.A851A

RYR2 5126_T CIN II No 1 237711847 237711847 C T nonsynonymous_SNV RYR2:NM_001035:exon26:c.C3023T:p.A1008V

AATK 6289_T MSI-H III No 17 79100287 79100287 C T nonsynonymous_SNV AATK:NM_004920:exon6:c.G386A:p.R129H

AATK 6289_T MSI-H III No 17 79096996 79096996 G A synonymous_SNV AATK:NM_004920:exon9:c.C801T:p.R267R

ABL2 6289_T MSI-H III No 1 179198527 179198527 C T synonymous_SNV ABL2:NM_001136001:exon1:c.G6A:p.G2G

AKAP6 6289_T MSI-H III No 14 33204956 33204956 A G synonymous_SNV AKAP6:NM_004274:exon11:c.A3240G:p.V1080V

APC 6289_T MSI-H III No 5 112175973 112175973 A - frameshift_deletion APC:NM_001127511:exon14:c.4628delA:p.K1543fs

APC2 6289_T MSI-H III No 19 1466603 1466603 G T nonsynonymous_SNV APC2:NM_005883:exon15:c.G3303T:p.E1101D

APC2 6289_T MSI-H III No 19 1453527 1453527 A G synonymous_SNV APC2:NM_005883:exon4:c.A330G:p.V110V

ARID1B 6289_T MSI-H III No 6 157511333 157511333 G - frameshift_deletion ARID1B:NM_017519:exon14:c.3812delG:p.G1271fs

ARID2 6289_T MSI-H III No 12 46243414 46243414 T C synonymous_SNV ARID2:NM_152641:exon14:c.T1767C:p.N589N

ATP2A3 6289_T MSI-H III No 17 3850811 3850811 C T synonymous_SNV ATP2A3:NM_005173:exon8:c.G969A:p.T323T

ATP2B2 6289_T MSI-H III No 3 10400513 10400513 G A synonymous_SNV ATP2B2:NM_001683:exon11:c.C1863T:p.C621C

ATP2B3 6289_T MSI-H III No X 152806883 152806883 C - frameshift_deletion ATP2B3:NM_001001344:exon2:c.275delC:p.P92fs

AXIN1 6289_T MSI-H III No 16 348099 348099 G A synonymous_SNV AXIN1:NM_003502:exon6:c.C1407T:p.S469S

BMPR2 6289_T MSI-H III No 2 203420006 203420006 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1618delA:p.I540fs

BMPR2 6289_T MSI-H III No 2 203420136 203420136 A - frameshift_deletion BMPR2:NM_001204:exon12:c.1748delA:p.N583fs

BRAF 6289_T MSI-H III No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1B 6289_T MSI-H III No 9 140938278 140938278 G A synonymous_SNV CACNA1B:NM_000718:exon21:c.G3339A:p.A1113A

CACNA1S 6289_T MSI-H III No 1 201031222 201031222 T C splicing mutation CACNA1S(NM_000069:exon25:c.2907-4A>G) CACNA2D3 6289_T MSI-H III No 3 54596945 54596945 T - frameshift_deletion CACNA2D3:NM_018398:exon6:c.663delT:p.F221fs

CALM3 6289_T MSI-H III No 19 47112140 47112140 A G nonsynonymous_SNV CALM3:NM_005184:exon5:c.A323G:p.H108R

CANX 6289_T MSI-H III No 5 179149927 179149927 T - frameshift_deletion CANX:NM_001024649:exon11:c.1305delT:p.F435fs

CD38 6289_T MSI-H III No 4 15780176 15780176 C T nonsynonymous_SNV CD38:NM_001775:exon1:c.C139T:p.R47C

CDKN2A 6289_T MSI-H III No 9 21970987 21970987 C T nonsynonymous_SNV CDKN2A:NM_000077:exon2:c.G371A:p.R124H

CHD3 6289_T MSI-H III No 17 7798771 7798771 C - frameshift_deletion CHD3:NM_001005271:exon10:c.1795delC:p.R599fs

CHD5 6289_T MSI-H III No 1 6196698 6196698 A - frameshift_deletion CHD5:NM_015557:exon17:c.2575delT:p.F859fs

CHD7 6289_T MSI-H III No 8 61693846 61693846 - A frameshift_insertion CHD7:NM_017780:exon3:c.1953dupA:p.K651fs

CHD7 6289_T MSI-H III No 8 61750244 61750244 T C synonymous_SNV CHD7:NM_017780:exon18:c.T4203C:p.H1401H

CHD8 6289_T MSI-H III No 14 21862141 21862141 G A nonsynonymous_SNV CHD8:NM_001170629:exon31:c.C5813T:p.A1938V

CHD8 6289_T MSI-H III No 14 21899682 21899682 T C nonsynonymous_SNV CHD8:NM_001170629:exon1:c.A121G:p.S41G

CREBBP 6289_T MSI-H III No 16 3808913 3808913 T C nonsynonymous_SNV CREBBP:NM_001079846:exon16:c.A3197G:p.Q1066R

CTNNBL1 6289_T MSI-H III No 20 36361422 36361422 A - frameshift_deletion CTNNBL1:NM_030877:exon2:c.172delA:p.R58fs

DNMT3B 6289_T MSI-H III No 20 31395624 31395624 G A nonsynonymous_SNV DNMT3B:NM_001207056:exon18:c.G2000A:p.R667H

DOCK3 6289_T MSI-H III No 3 51417610 51417610 C - frameshift_deletion DOCK3:NM_004947:exon52:c.5555delC:p.P1852fs

DOCK3 6289_T MSI-H III No 3 51266985 51266985 G A nonsynonymous_SNV DOCK3:NM_004947:exon19:c.G1862A:p.R621Q

EPHB6 6289_T MSI-H III No 7 142562315 142562315 G - frameshift_deletion EPHB6:NM_004445:exon7:c.757delG:p.A253fs

EPHB6 6289_T MSI-H III No 7 142562052 142562054 CCT - nonframeshift_deletion EPHB6:NM_004445:exon7:c.494_496del:p.165_166del

EPHB6 6289_T MSI-H III No 7 142561867 142561867 G A synonymous_SNV EPHB6:NM_004445:exon7:c.G309A:p.A103A

FHOD3 6289_T MSI-H III No 18 34205521 34205521 C - frameshift_deletion FHOD3:NM_025135:exon10:c.1005delC:p.P335fs

FLT3 6289_T MSI-H III No 13 28636175 28636175 G A nonsynonymous_SNV FLT3:NM_004119:exon3:c.C197T:p.A66V

FYN 6289_T MSI-H III No 6 112025282 112025282 C T nonsynonymous_SNV FYN:NM_153047:exon4:c.G467A:p.R156Q

FYN 6289_T MSI-H III No 6 112029133 112029133 C A nonsynonymous_SNV FYN:NM_153047:exon3:c.G435T:p.Q145H

GNAS 6289_T MSI-H III No 20 57429951 57429951 G A nonsynonymous_SNV GNAS:NM_001077490:exon1:c.G1444A:p.G482S

HDAC6 6289_T MSI-H III No X 48674991 48674991 T C nonsynonymous_SNV HDAC6:NM_006044:exon19:c.T1742C:p.L581P

HLTF 6289_T MSI-H III No 3 148777598 148777598 A G splicing mutation HLTF(NM_003071:exon14:c.1286-4T>C

IGF1R 6289_T MSI-H III No 15 99478221 99478221 G A nonsynonymous_SNV IGF1R:NM_000875:exon16:c.G3125A:p.R1042H

IGF1R 6289_T MSI-H III No 15 99500336 99500336 C T nonsynonymous_SNV IGF1R:NM_000875:exon21:c.C3769T:p.P1257S

IRS2 6289_T MSI-H III No 13 110436170 110436170 C T nonsynonymous_SNV IRS2:NM_003749:exon1:c.G2231A:p.R744H

ITPR3 6289_T MSI-H III No 6 33647857 33647857 C T synonymous_SNV ITPR3:NM_002224:exon31:c.C4171T:p.L1391L

JMJD1C 6289_T MSI-H III No 10 64952706 64952706 T - frameshift_deletion JMJD1C:NM_004241:exon13:c.5357delA:p.E1786fs

JMJD4 6289_T MSI-H III No 1 227920270 227920270 G A synonymous_SNV JMJD4:NM_001161465:exon6:c.C1167T:p.D389D

KDM5C 6289_T MSI-H III No X 53231149 53231149 G A nonsynonymous_SNV KDM5C:NM_001146702:exon11:c.C1552T:p.R518C

LEPREL1 6289_T MSI-H III No 3 189706761 189706761 C T nonsynonymous_SNV LEPREL1:NM_001134418:exon4:c.G347A:p.R116H LTK 6289_T MSI-H III No 15 41799478 41799478 C A nonsynonymous_SNV LTK:NM_206961:exon10:c.G1173T:p.K391N

MAP3K14 6289_T MSI-H III No 17 43351570 43351570 C T unknown UNKNOWN

MAPK3 6289_T MSI-H III No 16 30128170 30128170 C - frameshift_deletion MAPK3:NM_001040056:exon7:c.1062delG:p.Q354fs

MERTK 6289_T MSI-H III No 2 112765985 112765985 C T synonymous_SNV MERTK:NM_006343:exon14:c.C1893T:p.I631I

MLL2 6289_T MSI-H III No 12 49426730 49426732 GCT - nonframeshift_deletion MLL2:NM_003482:exon39:c.11756_11758del:p.3919_3920del

MLL4 6289_T MSI-H III No 19 36224407 36224407 C T synonymous_SNV MLL4:NM_014727:exon28:c.C6957T:p.G2319G

MTHFD2L 6289_T MSI-H III No 4 75147263 75147263 C T synonymous_SNV MTHFD2L:NM_001144978:exon7:c.C927T:p.F309F

MTOR 6289_T MSI-H III No 1 11303221 11303221 G A synonymous_SNV MTOR:NM_004958:exon9:c.C1362T:p.R454R

NAV3 6289_T MSI-H III No 12 78583896 78583896 C T nonsynonymous_SNV NAV3:NM_014903:exon33:c.C6122T:p.T2041I

PAK7 6289_T MSI-H III No 20 9546783 9546783 C T synonymous_SNV PAK7:NM_177990:exon5:c.G1239A:p.P413P

PDK2 6289_T MSI-H III No 17 48185995 48185995 G - frameshift_deletion PDK2:NM_001199899:exon9:c.689delG:p.G230fs

PDK2 6289_T MSI-H III No 17 48183498 48183498 G T synonymous_SNV PDK2:NM_001199900:exon4:c.G582T:p.R194R

PHF10 6289_T MSI-H III No 6 170104154 170104154 G - frameshift_deletion PHF10:NM_018288:exon12:c.1442delC:p.A481fs

PIK3C2A 6289_T MSI-H III No 11 17118740 17118740 C T nonsynonymous_SNV PIK3C2A:NM_002645:exon26:c.G4190A:p.R1397H

PLCB1 6289_T MSI-H III No 20 8770833 8770833 G A synonymous_SNV PLCB1:NM_015192:exon31:c.G3348A:p.A1116A

PLCB3 6289_T MSI-H III No 11 64032522 64032522 C - frameshift_deletion PLCB3:NM_001184883:exon21:c.2551delC:p.R851fs

PLCB3 6289_T MSI-H III No 11 64022914 64022914 G A nonsynonymous_SNV PLCB3:NM_001184883:exon4:c.G313A:p.V105I

PLCD3 6289_T MSI-H III No 17 43209679 43209679 C T unknown UNKNOWN

PRKAR1B 6289_T MSI-H III No 7 720287 720287 G - frameshift_deletion PRKAR1B:NM_001164758:exon3:c.254delC:p.T85fs

PRKDC 6289_T MSI-H III No 8 48866919 48866919 T - unknown UNKNOWN

PTPN14 6289_T MSI-H III No 1 214542933 214542933 C T synonymous_SNV PTPN14:NM_005401:exon17:c.G3138A:p.T1046T

PTPN3 6289_T MSI-H III No 9 112170606 112170606 A G nonsynonymous_SNV PTPN3:NM_001145372:exon6:c.T634C:p.S212P

PTPN6 6289_T MSI-H III No 12 7061292 7061292 T C nonsynonymous_SNV PTPN6:NM_002831:exon3:c.T278C:p.I93T

PTPN6 6289_T MSI-H III No 12 7069358 7069358 G A nonsynonymous_SNV PTPN6:NM_002831:exon13:c.G1537A:p.A513T

PTPRG 6289_T MSI-H III No 3 62278843 62278843 A G nonsynonymous_SNV PTPRG:NM_002841:exon30:c.A4199G:p.Y1400C

PTPRK 6289_T MSI-H III No 6 128404924 128404924 - T frameshift_insertion PTPRK:NM_001135648:exon9:c.1511dupA:p.E504fs

PTPRN 6289_T MSI-H III No 2 220159768 220159768 C T synonymous_SNV PTPRN:NM_001199763:exon18:c.G2517A:p.T839T

PTPRT 6289_T MSI-H III No 20 41400185 41400185 C T nonsynonymous_SNV PTPRT:NM_007050:exon5:c.G574A:p.A192T

PTPRT 6289_T MSI-H III No 20 40743943 40743943 G A stopgain_SNV PTPRT:NM_007050:exon22:c.C2995T:p.R999X

RASGRF2 6289_T MSI-H III No 5 80256846 80256846 G A splicing mutation RASGRF2(NM_006909:exon1:c.288+1G>A)

RELA 6289_T MSI-H III No 11 65422201 65422201 G T nonsynonymous_SNV RELA:NM_001145138:exon11:c.C1295A:p.T432K

RICTOR 6289_T MSI-H III No 5 39002687 39002687 G T synonymous_SNV RICTOR:NM_152756:exon5:c.C342A:p.S114S

RYK 6289_T MSI-H III No 3 133930364 133930364 G A unknown UNKNOWN

RYR1 6289_T MSI-H III No 19 39005702 39005702 G A nonsynonymous_SNV RYR1:NM_000540:exon64:c.G9509A:p.C3170Y RYR1 6289_T MSI-H III No 19 39008262 39008262 G T nonsynonymous_SNV RYR1:NM_000540:exon66:c.G9949T:p.G3317W

RYR1 6289_T MSI-H III No 19 39056154 39056154 G A nonsynonymous_SNV RYR1:NM_001042723:exon90:c.G13165A:p.E4389K

RYR1 6289_T MSI-H III No 19 38964244 38964244 C T synonymous_SNV RYR1:NM_000540:exon28:c.C3993T:p.Y1331Y

RYR3 6289_T MSI-H III No 15 34113005 34113005 A - frameshift_deletion RYR3:NM_001243996:exon77:c.10792delA:p.T3598fs

SGPL1 6289_T MSI-H III No 10 72619197 72619197 G A nonsynonymous_SNV SGPL1:NM_003901:exon7:c.G556A:p.A186T

SHMT1 6289_T MSI-H III No 17 18250893 18250893 C - frameshift_deletion SHMT1:NM_004169:exon5:c.436delG:p.G146fs

SKP1 6289_T MSI-H III No 5 133494246 133494246 G A nonsynonymous_SNV SKP1:NM_006930:exon5:c.C356T:p.T119I

SLC25A31 6289_T MSI-H III No 4 128651816 128651816 C T nonsynonymous_SNV SLC25A31:NM_031291:exon1:c.C116T:p.A39V

SLC8A1 6289_T MSI-H III No 2 40342530 40342530 G A nonsynonymous_SNV SLC8A1:NM_001112801:exon8:c.C2746T:p.R916W

SLC8A2 6289_T MSI-H III No 19 47933619 47933619 G A synonymous_SNV SLC8A2:NM_015063:exon10:c.C2493T:p.G831G

SLC8A3 6289_T MSI-H III No 14 70635058 70635058 G T nonsynonymous_SNV SLC8A3:NM_033262:exon2:c.C82A:p.L28I

SOCS6 6289_T MSI-H III No 18 67992682 67992682 C T nonsynonymous_SNV SOCS6:NM_004232:exon2:c.C778T:p.R260C

SYK 6289_T MSI-H III No 9 93637033 93637033 G T nonsynonymous_SNV SYK:NM_001135052:exon8:c.G1014T:p.K338N

TCF7L2 6289_T MSI-H III No 10 114925325 114925325 A - frameshift_deletion TCF7L2:NM_001198530:exon11:c.1159delA:p.S387fs

TCF7L2 6289_T MSI-H III No 10 114925707 114925707 G A synonymous_SNV TCF7L2:NM_001146285:exon13:c.G1716A:p.S572S

TGFBR2 6289_T MSI-H III No 3 30691880 30691881 AA - frameshift_deletion TGFBR2:NM_003242:exon3:c.382_383del:p.128_128del

TK2 6289_T MSI-H III No 16 66547719 66547719 C A splicing mutation TK2(NM_004614:exon10:c.619-5G>T

TRDN 6289_T MSI-H III No 6 123759216 123759216 T - frameshift_deletion TRDN:NM_001251987:exon12:c.1046delA:p.E349fs

TRPC1 6289_T MSI-H III No 3 142522935 142522937 TTG - nonframeshift_deletion TRPC1:NM_003304:exon10:c.1772_1774del:p.591_592del

TRRAP 6289_T MSI-H III No 7 98552764 98552764 C T nonsynonymous_SNV TRRAP:NM_003496:exon39:c.C5699T:p.A1900V

APC 6484_T CIN II No 5 112175751 112175751 C - frameshift_deletion APC:NM_001127511:exon14:c.4406delC:p.T1469fs

APC 6484_T CIN II No 5 112173917 112173917 C T stopgain_SNV APC:NM_001127511:exon14:c.C2572T:p.R858X

ARID1A 6484_T CIN II No 1 27023880 27023880 C - frameshift_deletion ARID1A:NM_006015:exon1:c.986delC:p.P329fs

GRIN1 6484_T CIN II No 9 140051148 140051148 C T synonymous_SNV GRIN1:NM_000832:exon5:c.C699T:p.R233R

KAT2B 6484_T CIN II No 3 20161118 20161118 - G frameshift_insertion KAT2B:NM_003884:exon8:c.1179_1180insG:p.T393fs

KDR 6484_T CIN II No 4 55961125 55961125 A G splicing mutation KDR(NM_002253:exon22:c.2818-3T>C)

NRAS 6484_T CIN II No 1 115258747 115258747 C T nonsynonymous_SNV NRAS:NM_002524:exon2:c.G35A:p.G12D

PAK2 6484_T CIN II No 3 196529926 196529926 C A synonymous_SNV PAK2:NM_002577:exon4:c.C327A:p.S109S

PTPRZ1 6484_T CIN II No 7 121699906 121699906 G T nonsynonymous_SNV PTPRZ1:NM_001206839:exon28:c.G4170T:p.M1390I

RGS4 6484_T CIN II No 1 163044148 163044148 G A nonsynonymous_SNV RGS4:NM_001113380:exon5:c.G362A:p.R121Q

RYR2 6484_T CIN II No 1 237947552 237947552 C T synonymous_SNV RYR2:NM_001035:exon90:c.C12540T:p.G4180G

TIE1 6484_T CIN II No 1 43778254 43778254 G A nonsynonymous_SNV TIE1:NM_001253357:exon12:c.G1774A:p.V592M

TP53 6484_T CIN II No 17 7577141 7577141 C A nonsynonymous_SNV TP53:NM_001126115:exon4:c.G401T:p.G134V

TSC2 6484_T CIN II No 16 2133701 2133701 G A nonsynonymous_SNV TSC2:NM_001077183:exon31:c.G3688A:p.A1230T APC 668_T CIN III No 5 112173835 112173835 A - frameshift_deletion APC:NM_001127511:exon14:c.2490delA:p.K830fs

APC 668_T CIN III No 5 112175720 112175720 C T stopgain_SNV APC:NM_001127511:exon14:c.C4375T:p.Q1459X

APC2 668_T CIN III No 19 1467588 1467588 G A nonsynonymous_SNV APC2:NM_005883:exon15:c.G4288A:p.G1430S

CHD9 668_T CIN III No 16 53190475 53190475 A G synonymous_SNV CHD9:NM_025134:exon2:c.A474G:p.A158A

GRIN2A 668_T CIN III No 16 9943819 9943819 C G splicing mutation GRIN2A(NM_001134407:exon6:c.1123-1G>C

HDAC9 668_T CIN III No 7 18767296 18767296 G A nonsynonymous_SNV HDAC9:NM_058176:exon12:c.G1816A:p.V606I

IRS1 668_T CIN III No 2 227661381 227661381 C T nonsynonymous_SNV IRS1:NM_005544:exon1:c.G2074A:p.G692R

KRAS 668_T CIN III No 12 25398284 25398284 C T nonsynonymous_SNV KRAS:NM_004985:exon2:c.G35A:p.G12D

MTHFD2 668_T CIN III No 2 74433001 74433001 G A nonsynonymous_SNV MTHFD2:NM_006636:exon2:c.G271A:p.A91T

PIK3CA 668_T CIN III No 3 178936082 178936082 G A nonsynonymous_SNV p.E542K

PRKD1 668_T CIN III No 14 30107744 30107744 A T stopgain_SNV PRKD1:NM_002742:exon6:c.T936A:p.C312X

RNF111 668_T CIN III No 15 59347929 59347929 C A synonymous_SNV RNF111:NM_001270528:exon4:c.C1056A:p.S352S

ROS1 668_T CIN III No 6 117725578 117725578 T A synonymous_SNV ROS1:NM_002944:exon5:c.A303T:p.L101L

RYR3 668_T CIN III No 15 34021137 34021137 C T synonymous_SNV RYR3:NM_001036:exon47:c.C7113T:p.R2371R

SMAD4 668_T CIN III No 18 48591826 48591826 A G nonsynonymous_SNV SMAD4:NM_005359:exon9:c.A989G:p.E330G

APC 6930_T CIN III Yes 5 112164616 112164616 C T stopgain_SNV APC:NM_001127511:exon12:c.C1636T:p.R546X

APC 6930_T CIN III Yes 5 112175174 112175174 G T stopgain_SNV APC:NM_001127511:exon14:c.G3829T:p.E1277X

ATP2B2 6930_T CIN III Yes 3 10491053 10491053 G A nonsynonymous_SNV ATP2B2:NM_001001331:exon2:c.C175T:p.R59C

CACNA1E 6930_T CIN III Yes 1 181767868 181767868 C T synonymous_SNV CACNA1E:NM_001205294:exon46:c.C6654T:p.N2218N

CACNA1H 6930_T CIN III Yes 16 1252155 1252155 G A nonsynonymous_SNV CACNA1H:NM_001005407:exon9:c.G1705A:p.A569T

CACNG1 6930_T CIN III Yes 17 65052193 65052193 C T nonsynonymous_SNV CACNG1:NM_000727:exon4:c.C475T:p.R159W

CDH20 6930_T CIN III Yes 18 59195201 59195201 C A nonsynonymous_SNV CDH20:NM_031891:exon6:c.C1019A:p.P340H

CSF1R 6930_T CIN III Yes 5 149439304 149439304 G A synonymous_SNV CSF1R:NM_005211:exon15:c.C2091T:p.V697V

CTNND2 6930_T CIN III Yes 5 11117603 11117603 C T nonsynonymous_SNV CTNND2:NM_001332:exon13:c.G2236A:p.V746M

LCK 6930_T CIN III Yes 1 32745726 32745726 C T synonymous_SNV LCK:NM_001042771:exon12:c.C1242T:p.Y414Y

PAK2 6930_T CIN III Yes 3 196529926 196529926 C A synonymous_SNV PAK2:NM_002577:exon4:c.C327A:p.S109S

RELB 6930_T CIN III Yes 19 45541029 45541029 C T unknown UNKNOWN

TP53 6930_T CIN III Yes 17 7578191 7578191 A G nonsynonymous_SNV TP53:NM_001126115:exon2:c.T262C:p.Y88H

ADAMTSL3 8528_T CIN III No 15 84651189 84651189 C T stopgain_SNV ADAMTSL3:NM_207517:exon21:c.C2809T:p.R937X

APC 8528_T CIN III No 5 112175951 112175951 G T stopgain_SNV APC:NM_001127511:exon14:c.G4606T:p.E1536X

ATP2A2 8528_T CIN III No 12 110783097 110783097 G A nonsynonymous_SNV ATP2A2:NM_001681:exon18:c.G2651A:p.G884D

BRAF 8528_T CIN III No 7 140453136 140453136 A T nonsynonymous_SNV BRAF:NM_004333:exon15:c.T1799A:p.V600E

CACNA1A 8528_T CIN III No 19 13414691 13414691 G A nonsynonymous_SNV CACNA1A:NM_001127221:exon16:c.C1997T:p.T666M

CREBBP 8528_T CIN III No 16 3900721 3900721 C T synonymous_SNV CREBBP:NM_001079846:exon2:c.G375A:p.Q125Q DRD2 8528_T CIN III No 11 113281645 113281645 G A splicing mutation DRD2(NM_000795:exon9:c.1139-3C>T

GRIN2D 8528_T CIN III No 19 48946405 48946405 A G synonymous_SNV GRIN2D:NM_000836:exon13:c.A3222G:p.P1074P

MATK 8528_T CIN III No 19 3783158 3783158 G A synonymous_SNV MATK:NM_139354:exon6:c.C519T:p.H173H

NTRK3 8528_T CIN III No 15 88576236 88576236 G T nonsynonymous_SNV NTRK3:NM_001243101:exon13:c.C1413A:p.S471R

PIK3C2B 8528_T CIN III No 1 204413251 204413251 G T nonsynonymous_SNV PIK3C2B:NM_002646:exon19:c.C2812A:p.R938S

RYR1 8528_T CIN III No 19 38951181 38951181 C T nonsynonymous_SNV RYR1:NM_000540:exon20:c.C2527T:p.R843C

RYR1 8528_T CIN III No 19 39019013 39019013 C A nonsynonymous_SNV RYR1:NM_001042723:exon73:c.C10877A:p.A3626E

SOCS5 8528_T CIN III No 2 46986691 46986691 G A nonsynonymous_SNV SOCS5:NM_014011:exon2:c.G1022A:p.R341H

TEK 8528_T CIN III No 9 27213580 27213580 T C synonymous_SNV TEK:NM_000459:exon18:c.T2976C:p.Y992Y

TP53 8528_T CIN III No 17 7577094 7577094 G A nonsynonymous_SNV TP53:NM_001126115:exon4:c.C448T:p.R150W

TRRAP 8528_T CIN III No 7 98519541 98519541 G A nonsynonymous_SNV TRRAP:NM_001244580:exon21:c.G2788A:p.D930N

APC 8764_T CIN III Yes 5 112175390 112175390 C T stopgain_SNV APC:NM_001127511:exon14:c.C4045T:p.Q1349X

ATIC 8764_T CIN III Yes 2 216182920 216182920 G T stopgain_SNV ATIC:NM_004044:exon3:c.G187T:p.G63X

CD38 8764_T CIN III Yes 4 15780256 15780256 T G nonsynonymous_SNV CD38:NM_001775:exon1:c.T219G:p.I73M

DOCK3 8764_T CIN III Yes 3 51317580 51317580 G A nonsynonymous_SNV DOCK3:NM_004947:exon27:c.G2867A:p.C956Y

FBXW7 8764_T CIN III Yes 4 153247289 153247289 G A nonsynonymous_SNV FBXW7:NM_001013415:exon9:c.C1159T:p.R387C

KAT6A 8764_T CIN III Yes 8 41791083 41791083 T C nonsynonymous_SNV KAT6A:NM_006766:exon17:c.A4655G:p.D1552G

KRAS 8764_T CIN III Yes 12 25378647 25378647 T G nonsynonymous_SNV KRAS:NM_004985:exon4:c.A351C:p.K117N

MAPK4 8764_T CIN III Yes 18 48255572 48255572 G A nonsynonymous_SNV MAPK4:NM_002747:exon6:c.G1112A:p.R371Q

MAPK4 8764_T CIN III Yes 18 48255897 48255897 G A synonymous_SNV MAPK4:NM_002747:exon6:c.G1437A:p.T479T

NTRK3 8764_T CIN III Yes 15 88799384 88799384 T G nonsynonymous_SNV NTRK3:NM_001007156:exon3:c.A1C:p.M1L

PLCG2 8764_T CIN III Yes 16 81944235 81944236 AG - frameshift_deletion PLCG2:NM_002661:exon18:c.1844_1845del:p.615_615del

RYR1 8764_T CIN III Yes 19 38956847 38956847 C T nonsynonymous_SNV RYR1:NM_000540:exon24:c.C2987T:p.A996V

SMARCA4 8764_T CIN III Yes 19 11094865 11094865 G A nonsynonymous_SNV SMARCA4:NM_001128845:exon1:c.G38A:p.R13Q

SNIP1 8764_T CIN III Yes 1 38005793 38005793 C T synonymous_SNV SNIP1:NM_024700:exon3:c.G891A:p.P297P

TEK 8764_T CIN III Yes 9 27206597 27206597 G T synonymous_SNV TEK:NM_000459:exon15:c.G2382T:p.V794V

TP53 8764_T CIN III Yes 17 7577094 7577094 G A nonsynonymous_SNV TP53:NM_001126115:exon4:c.C448T:p.R150W