Human DIABLO / SMAC (56-239) - Purified

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AR03005PU-N Human DIABLO / SMAC (56-239) - Purified

Alternate names: Diablo homolog mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase Quantity: 0.1 mg Concentration: 1.0 mg/ml Background: Smac/Diablo is one of the proapoptotic proteins. Smac promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. Uniprot ID: Q9NR28 NCBI: NP_063940.1 GeneID: 56616 Species: Human Source: E. coli Format: State: Liquid protein, purified by conventional chromatography techniques Purity: >95% > 95 % by SDS PAGE Buffer System: 20mM Tris pH 7.5 Description: Recombinant human Smac fused to T7-tag. AA Sequence: MASMTGGQQM GRGSMAVPIA QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED Molecular weight: 22 kDa 22 kDa (199 aa) Add. Information: NCBI Accession No: NP_063940 Storage: Store at -20°C. Avoid repeated freezing and thawing. Shelf life: six months from despatch. General Readings: 1. Srinivasula SM., et al. (2000). J Biol Chem. 275(46):36152-7. 2. DU C., et al. (2000). Cell. 102(1):33-42.

For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130513 1 / 2 AR03005PU-N: Human DIABLO / SMAC (56-239) - Purified

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For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130513 2 / 2