JOURNAL OF VIROLOGY

Volume 68 February 1994 No. 2

ANITMAL Truncation of the Cytoplasmic Domain of the Simian C. Peter Spies, G. Douglas Ritter, 585-591 Immunodeficiency Envelope Alters Jr., Mark J. Mulligan, and Richard the Conformation of the External Domain W. Compans A Novel Hantavirus Associated with an Outbreak of Fatal Brian Hjelle, Steven Jenison, 592-596 Respiratory Disease in the Southwestern United States: Norah Torrez-Martinez, Takashi Evolutionary Relationships to Known Hantaviruses Yamada, Kurt Nolte, Ross Zumwalt, Kersti MacInnes, and Gerald Myers Nucleotide Sequence Analysis of a 38.5-Kilobase-Pair Region John Nicholas and Michelle E. D. 597-610 of the of Encoding Human Martin Cytomegalovirus Immediate-Early Gene Homologs and Transactivating Functions A Specific Orientation of RNA Secondary Structures Is Ashok Aiyar, Zheng Ge, and 611-618 Required for Initiation of Reverse Transcription Jonathan Leis Interaction of Human Papiliomavirus (HPV) Type 16 Jian Zhou, Xiao-yi Sun, Kylie 619-625 with HPV DNA Requires an Intact L2 N-Terminal Louis, and Ian H. Frazer Sequence Rapid Phenotypic Reversion of Zidovudine-Resistant Feline Kathryn Martin Remington, Ya-Qi 632-637 Immunodeficiency Virus without Loss of Drug-Resistant Zhu, Tom R. Phillips, and Thomas W. North The Human Foamy Virus Internal Promoter Directs the Martin L6chelt, Rolf M. Flugel, 638-645 Expression of the Functional Bel 1 Transactivator and Bet and Mordechai Aboud Early after Infection Mutational Analysis of Delta Antigen: Effect on Assembly Ming-Fu Chang, Chun-Jung Chen, 646-653 and Replication of Hepatitis Delta Virus and Shin C. Chang A Small and Efficient Dimerization/Packaging Signal of Christophe Torrent, Caroline 661-667 Rat VL3O RNA and Its Use in Murine Leukemia Gabus, and Jean-Luc Darlix Virus-VL3O-Derived Vectors for Gene Transfer Resistance to Neutralization by Broadly Reactive Markus Thali, MacArthur Charles, 674-680 to the Human Immunodeficiency Virus Type 1 gpl20 Craig Furman, Lisa Cavacini, Glycoprotein Conferred by a gp4l Change Marshall Posner, James Robinson, and Joseph Sodroski trans Complementation by RNA of Defective Jeff Drew and Graham J. Belsham 697-703 Foot-and-Mouth Disease Virus Internal Ribosome Entry Site Elements Subcellular Localization of the Vif Protein of Human Joao Goncalves, Prasad Jallepalli, 704-712 Immunodeficiency Virus Type 1 and Dana H. Gabuzda Rescue of Synthetic Genomic RNA Analogs of Rabies Virus Karl-Klaus Conzelmann and 713-719 by Plasmid-Encoded Proteins Matthias Schnell The Human Cytomegalovirus 86-Kilodalton Loma A. Samaniego, Mary J. 720-729 Immediate-Early 2 Protein: Synthesis as a Precursor Tevethia, and David J. Spector Polypeptide and Interaction with a 75-Kilodalton Protein of Probable Viral Origin Sequence Diversity within the Reovirus S2 Gene: Reovirus James D. Chappell, Mehmet I. 750-756 Genes Reassort in Nature, and Their Termini Are Predicted Goral, Steven E. Rodgers, Claude to Form a Panhandle Motif W. dePamphilis, and Terence S. Dermody

Continued on following page Continued from preceding page

Antiviral Activity of Human Immunodeficiency Virus Type 1 Karoly Nagy, Matthew Young, 757-765 Protease Inhibitors in a Single Cycle of Infection: Evidence Christina Baboonian, James for a Role of Protease in the Early Phase Merson, Peter Whittle, and Stephen Oroszlan High-Level Expression and Purification of Secreted Forms of William P. Sisk, Jodi D. Bradley, 766-775 Virus Type 1 Glycoprotein gD Synthesized Robert J. Leipold, Angeline M. by Baculovirus-Infected Insect Cells Stoltzfus, Manuel Ponce de Leon, Megan Hilf, Charline Peng, Gary H. Cohen, and Roselyn J. Eisenberg The Genomic Instability Associated with Integrated Simian Deborah J. Hunter and Elizabeth 787-796 Virus 40 DNA Is Dependent on the Origin of Replication G. Gurney and Early Control Region Biologically Active Rep Proteins of Adeno-Associated Virus John A. Chiorini, Matthew D. 797-804 Type 2 Produced as Fusion Proteins in Escherichia coli Weitzman, Roland A. Owens, Elena Urcelay, Brian Safer, and Robert M. Kotin Formation and Rearrangement of Bonds during Matthew Mulvey and Dennis T. 805-812 Maturation of the Sindbis Virus El Glycoprotein Brown Amino Acid Substitution Mutations in the Herpes Simplex Stephen A. Rice and Vivian Lam 823-833 Virus ICP27 Protein Define an Essential Gene Regulation Function E and I Facilitate Kevin S. Dingwell, Craig R. 834-845 -to-Cell Spread In Vivo and across Junctions of Brunetti, Robert L. Hendricks, Cultured Cells Qizhi Tang, Mary Tang, Andrew J. Rainbow, and David C. Johnson ART-CH: a VL3O in Chickens? Mikhail A. Nikiforov and Andrei 846-853 V. Gudkov Molecular Evolution of the Major Capsid Protein VP1 of Naokazu Takeda, Masako 854-862 Enterovirus 70 Tanimura, and Kikuko Miyamura Clustered Charged-to-Alanine Mutagenesis of Poliovirus Scott E. Diamond and Karla 863-876 RNA-Dependent RNA Polymerase Yields Multiple Kirkegaard Temperature-Sensitive Mutants Defective in RNA Synthesis Human Immunodeficiency Virus Expression Becomes Marie-Louise Hammarskjold, 951-958 Rev-Independent if the env Region Is Not Defined as an Hongbo Li, David Rekosh, and Intron Susan Prasad Negative-Strand RNA Transcripts Are Produced in Human Nelson L. Michael, Maryanne T. 979-987 Immunodeficiency Virus Type 1-Infected Cells and Patients Vahey, Lisa d'Arcy, Philip K. by a Novel Promoter Downregulated by Tat Ehrenberg, Joseph D. Mosca, Jay Rappaport, and Robert R. Redfield RNA Polymerase II Is Aberrantly Phosphorylated and Stephen A. Rice, Melissa C. Long, 988-1001 Localized to Viral Replication Compartments following Vivian Lam, and Charlotte A. Herpes Simplex Virus Infection Spencer Transcription Factor PRDII-BF1 Activates Human Jacob-S. Seeler, Christian 1002-1009 Immunodeficiency Virus Type 1 Gene Expression Muchardt, Amy Suessle, and Richard B. Gaynor Association between the p170 Form of Human S. N. Ebert, D. Subramanian, 1010-1020 Topoisomerase II and Progeny Viral DNA in Cells S. S. Shtrom, I. K. Chung, D. S. Infected with Herpes Simplex Virus Type 1 Parris, and M. T. Muller Transcriptional Mapping of the 3' End of the Bovine Randall W. Renshaw and James 1021-1028 Syncytial Virus Genome W. Casey Increase in Soluble CD4 Binding to and CD4-Induced Ronald L. Willey, Malcolm A. 1029-1039 Dissociation of gpl20 from Virions Correlates with Martin, and Keith W. C. Peden Infectivity of Human Immunodeficiency Virus Type 1

Continued on followingpage Continued from preceding page

Human Cytomegalovirus DNA Replicates after Early Michael A. McVoy and Stuart P. 1040-1051 Circularization by Concatemer Formation, and Inversion Adler Occurs within the Concatemer The Carbocyclic Analog of 2'-Deoxyguanosine Induces a Isabelle Fourel, Jeffrey Saputelli, 1059-1065 Prolonged Inhibition of Duck Hepatitis DNA Priscilla Schaffer, and William S. Synthesis in Primary Hepatocyte Cultures and in the Liver Mason In Vitro Characterization of an Internal Ribosomal Entry Edwin A. Brown, Allan J. Zajac, 1066-1074 Site (IRES) Present within the 5' Nontranslated Region of and Stanley M. Lemon Hepatitis A Virus RNA: Comparison with the IRES of Encephalomyocarditis Virus A Mutant Baculovirus with a Temperature-Sensitive IE-1 Bergmann M. Ribeiro, Karen 1075-1084 Transregulatory Protein Hutchinson, and Lois K. Miller The Bovine Papillomavirus Type 1 (BPV1) Replication Mikael A. Le Moal, Moshe Yaniv, 1085-1093 Protein El Modulates Transcriptional Activation by and Francoise Thierry Interacting with BPV1 E2 DNA Binding Specificity of the Bovine Papillomavirus El Shawn E. Holt, Genevieve 1094-1102 Protein Is Determined by Sequences Contained within an Schuller, and Van G. Wilson 18-Base-Pair Inverted Repeat Element at the Origin of Replication Assembly of Virus: Effects of Rifampin on the Beate Sodeik, Gareth Griffiths, 1103-1114 Intracellular Distribution of p65 Maria Ericsson, Bernard Moss, and Robert W. Doms Human Papillomavirus Type 11 E2 Proteins Repress the Gang Dong, Thomas R. Broker, 1115-1127 Homologous E6 Promoter by Interfering with the Binding of and Louise T. Chow Host Transcription Factors to Adjacent Elements In Vitro Replication of Adeno-Associated Virus DNA Tie-Hua Ni, Xiaohuai Zhou, 1128-1138 Douglas M. McCarty, Irene Zolotukhin, and Nicholas Muzyczka Correlation between Fusogenicity of Synthetic Modified I. Martin, M.-C. Dubois, F. 1139-1148 Peptides Corresponding to the NH2-Terminal Extremity of Defrise-Quertain, T. Saermark, A. Simian Immunodeficiency Virus gp32 and Their Mode of Burny, R. Brasseur, and J.-M. Insertion into the Lipid Bilayer: an Infrared Spectroscopy Ruysschaert Study Isolation and Characterization of Simian T-Cell Leukemia Yi-Ming A. Chen, Yng-Ju Jang, 1149-1157 Virus Type II from New World Monkeys Phyllis J. Kanki, Qian-Chun Yu, Jaang-Jiun Wang, Richard J. Montali, Kenneth P. Samuel, and Takis S. Papas Helix-Destabilizing Properties of the Adenovirus Diederik C. Zijderveld and Peter 1158-1164 DNA-Binding Protein C. van der Vliet In Vivo and In Vitro Analyses of Recombinant A. Lorena Passarelli and Lois K. 1186-1190 Baculoviruses Lacking a Functional cg3O Gene Miller Characterization of a Marek's Disease Virus Kazuhiko Ohashi, Wenping Zhou, 1191-1195 BamHI-L-Specific cDNA Clone Obtained from a Marek's Priscilla H. O'Connell, and Karel Disease Lymphoblastoid Cell Line A. Schat Different Activation of Epstein-Barr Virus Immediate-Early Christoph Bogedain, Peter Alliger, 1200-1203 and Early Genes in Burkitt Lymphoma Cells and Fritz Schwarzmann, Manfred Lymphoblastoid Cell Lines Marschall, Hans Wolf, and Wolfgang Jilg Adenovirus-Dependent Release of Choline from Plasma Prem Seth 1204-1206 Membrane Vesicles at an Acidic pH Is Mediated by the Penton Base Protein

Continued on following page Continued from preceding page

Sequence Specificity of Furin, a Proprotein-Processing John A. Walker, Sean S. Molloy, 1213-1218 Endoprotease, for the Hemagglutinin of a Virulent Avian Gary Thomas, Takemasa Virus Sakaguchi, Tetsuya Yoshida, Thomas M. Chambers, and Yoshihiro Kawaoka Adeno-Associated Virus Type 2 rep Gene-Mediated Ingo Oelze, Karola Rittner, and 1229-1233 Inhibition of Basal Gene Expression of Human Georg Sczakiel Immunodeficiency Virus Type 1 Involves Its Negative Regulatory Functions Adenovirus Type 40 and 41 Growth In Vitro: Host Range C. T. Tiemessen and A. H. Kidd 1239-1244 Diversity Reflected by Differences in Patterns of DNA Replication Characterization of the Polyadenylation Signal of Influenza Xingqiang Li and Peter Palese 1245-1249 Virus RNA Role of Neuraminidase in the Morphogenesis of Influenza B Fumi Yamamoto-Goshima, 1250-1254 Virus Koichiro Maeno, Takayuki Morishita, Masahiro Ueda, Yoshikazu Fujita, Katsuhisa Nakajima, and Saiji Yoshii Kinetics of Human Immunodeficiency Virus Type 1 Reverse William A. O'Brien, Ali Namazi, 1258-1263 Transcription in Blood Mononuclear Phagocytes Are Slowed Hamidreza Kalhor, Si-Hua Mao, by Limitations of Nucleotide Precursors Jerome A. Zack, and Irvin S. Y. Chen VIRUS-CELL INTERACTIONS Glycosylation-Dependent Inactivation of the Ecotropic Maribeth V. Eiden, Karen Farrell, 626-631 Receptor and Carolyn A. Wilson Distinct Modes of Human Immunodeficiency Virus Type 1 Benjamin K. Chen, Kalle Saksela, 654-660 Proviral Latency Revealed by Superinfection of Raul Andino, and David Baltimore Nonproductively Infected Cell Lines with Recombinant Luciferase-Encoding Viruses A Baculovirus gp64 Early Promoter Is Activated by Host Philip H. Kogan and Gary W. 813-822 Transcription Factor Binding to CACGTG and GATA Blissard Elements Human Transcription Factor YY1 Represses Human David M. Margolis, Mohan 905-910 Immunodeficiency Virus Type 1 Transcription and Virion Somasundaran, and Michael R. Production Green Influenza Virus M2 Protein Ion Channel Activity Stabilizes Kaoru Takeuchi and Robert A. 911-919 the Native Form of Fowl Plague Virus Hemagglutinin during Lamb Intracellular Transport Rescue of Vector-Expressed Fowl Plague Virus M. Ohuchi, A. Cramer, M. Vey, 920-926 Hemagglutinin in Biologically Active Form by Acidotropic R. Ohuchi, W. Garten, and H.-D. Agents and Coexpressed M2 Protein Klenk Mechanism of Enhancement of DNA Expression Consequent Prem Seth, Melissa Rosenfeld, 933-940 to Cointernalization of a Replication-Deficient Adenovirus James Higginbotham, and Ronald and Unmodified Plasmid DNA G. Crystal The Cellular Polypeptide p57 (Pyrimidine Tract-Binding Christopher U. T. Hellen, Tatyana 941-950 Protein) Binds to Multiple Sites in the Poliovirus 5' V. Pestova, Mark Litterst, and Nontranslated Region Eckard Wimmer The Effects of Cytomegalovirus on Human Franqoise M. Jault, Stephen A. 959-973 Immunodeficiency Virus Replication in Brain-Derived Cells Spector, and Deborah H. Spector Correlate with Permissiveness of the Cells for Each Virus Fusion from Without Directed by Human Immunodeficiency Francois Clavel and Pierre 1179-1185 V'irus Particles Charneau

Continued on followingpage Continued from preceding page

Mutations of Polyomavirus VP1 Allow In Vitro Growth in Beata Mezes and Paolo Amati 1196-1199 Undifferentiated Cells and Modify In Vivo Tissue Replication Specificity Sequences Present in the Cytoplasmic Domain of CD4 Are Ronald L. Willey, Alicia 1207-1212 Necessary and Sufficient to Confer Sensitivity to the Human Buckler-White, and Klaus Strebel Immunodeficiency Virus Type 1 Herpesvirus-Induced Cell Fusion That Is Dependent on Cell Mei-Tsu Shieh and Patricia G. 1224-1228 Surface Heparan Sulfate or Soluble Heparin Spear YY1 Is the Cellular Factor Shown Previously To Bind to Lisa K. Mills, Yang Shi, and 1234-1238 Regulatory Regions of Several Leaky-Late (13'y, 'yl) Genes of Robert L. Millette Herpes Simplex Virus Type 1

VIRAL AND CELLULAR Characterization of an Immortalizing N-Terminal Domain Patricia S. Holman, Ole V. 668-673 of Polyomavirus Large T Antigen Gjoerup, Tanja Davin, and Brian S. Schaffhausen Phosphorylation at the Carboxy Terminus of the Jose G. Teodoro, Todd Halliday, 776-786 55-Kilodalton Adenovirus Type 5 E1B Protein Regulates Steve G. Whalen, Dennis Transforming Activity Takayesu, Frank L. Graham, and Philip E. Branton Constructing Chimeric Type 12/lype 5 Adenovirus EIA Glenn C. Telling and Jim Williams 877-887 Genes and Using Them To Identify an Oncogenic Determinant of Adenovirus Type 12 Tumorigenicity of Adenovirus-Transformed Rodent Cells Is Tomas Jelinek, Daniel S. Pereira, 888-896 Influenced by At Least Two Regions of Adenovirus Type 12 and Frank L. Graham Early Region IA VIRAL PATHOGENESIS AND IMMUNITY Transgenic Mice Carrying the Human Poliovirus Receptor: Hitoshi Horie, Satoshi Koike, 681-688 a New Animal Model for Study of Poliovirus Neurovirulence Takeshi Kurata, Yasuko Sato-Yoshida, Iku Ise, Yoshihiro Ota, Shinobu Abe, Kyoji Hioki, Hideki Kato, Choji Taya, Tatsuji Nomura, Sou Hashizume, Hiromichi Yonekawa, and Akio Nomoto Immunization with Replication-Defective Mutants of Herpes Lynda A. Morrison and David M. 689-696 Simplex Virus Type 1: Sites of Immune Intervention in Knipe Pathogenesis of Challenge Virus Infection Inhibition of Complement-Mediated Cytolysis by the Russell P. Rother, Scott A. 730-737 Terminal Complement Inhibitor of Herpesvirus Saimiri Rollins, William L. Fodor, Jens-C. Albrecht, Eva Setter, Bernhard Fleckenstein, and Stephen P. Squinto Pathogenesis of Aleutian Mink Disease Parvovirus Infection: Soren Alexandersen, Torben 738-749 Effects of Suppression of Response on Viral Storgaard, Nerry Kamstrup, Bent mRNA Levels and on Development of Acute Disease Aasted, and David D. Porter An Immunodominant Kb-Restricted Peptide from the piSE Hillary D. White, Douglas A. 897-904 Transmembrane Protein of Endogenous Ecotropic Murine Roeder, and William R. Green Leukemia Virus (MuLV) AKR623 That Restores Susceptibility of a Tumor Line to Anti-AKR/Gross MuLV Cytotoxic T Potential of a Herpes Simplex Virus Type 1 Mutant H. E. Farrell, C. S. McLean, C. 927-932 with an Essential Glycoprotein Deleted Harley, S. Efstathiou, S. Inglis, and A. C. Minson

Continued on followingpage Continued from preceding page

Characterization of Mutants of Human Immunodeficiency Hironori Yoshiyama, Hongmei 974-978 Virus Type 1 That Have Escaped Neutralization by a Mo, John P. Moore, and David Monoclonal Antibody to the gpl20 V2 Loop D. Ho Expression of the Hepatitis Delta Virus Large and Small Stephane Guilhot, Shao-nan 1052-1058 Antigens in Transgenic Mice Huang, Yu Ping Xia, Nicola La Monica, Michael M. C. Lai, and Francis V. Chisari Radiation Leukemia Virus-Induced Thymic Lymphomas Anis Sen-Majumdar, Irving L. 1165-1172 Express a Restricted Repertoire of T-Cell Receptor V13 Weissman, Gun Hansteen, Janet Gene Products Marian, Edmund K. Waller, and Miriam Lieberman Human Herpesvirus 6 Infects Cervical Epithelial Cells and M. Chen, N. Popescu, C. 1173-1178 Transactivates Human Papillomavirus Gene Expression Woodworth, Z. Berneman, M. Corbellino, P. Lusso, D. V. Ablashi, and J. A. DiPaolo Importance of Amino Acid 101 within Capsid Protein VP1 Yoshiaki Wada, Michael L. Pierce, 1219-1223 for Modulation of Theiler's Virus-Induced Disease and Robert S. Fujinami Association of Bluetongue Virus Gene Segment 5 with Margaret A. Carr, Cecilia C. 1255-1257 Neuroinvasiveness de Mattos, Carlos A. de Mattos, and Bennie I. Osburn AUTHOR'S CORRECTION The RR1 Gene of Herpes Simplex Virus Type 1 Is Uniquely Preshant Desai, Ramesh 1264 trans Activated by ICPO during Infection Ramakrishnan, Zhi Wu Lin, Bella Osak, Joseph C. Glorioso, and Myron Levine